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ACD

ACD shelterin complex subunit and telomerase recruitment factor
General Information
Name ACD shelterin complex subunit and telomerase recruitment factor
Alias
  • adrenocortical dysplasia protein homolog
  • POT1 and TIN2-interacting protein
  • TIN2 interacting protein 1
  • adrenocortical dysplasia homolog
Gene_family Shelterin complex
organism Homo sapiens
entrez_id 65057
location 16q22.1
transcript_count 4
exon_count 12
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]
    Stringdb Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodim [...]
    nextProt Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
ACD BioGRID HAPSTR1 GeneID BioGRID Negative Genetic
ACD BioGRID RB1 GeneID BioGRID Negative Genetic
ACD BioGRID UPF1 GeneID BioGRID Affinity Capture-Western
ACD BioGRID TINF2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
ACD BioGRID Paxip1 GeneID BioGRID Affinity Capture-MS
ACD BioGRID POF1B GeneID BioGRID Affinity Capture-MS
ACD BioGRID TERF2IP GeneID BioGRID Affinity Capture-MS
ACD BioGRID POT1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ACD BioGRID KEAP1 GeneID BioGRID Affinity Capture-MS
ACD BioGRID TERF1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
ACD BioGRID HSPA8 GeneID BioGRID Affinity Capture-MS
ACD BioGRID FBXW7 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ACD BioGRID TRIM63 GeneID BioGRID Two-hybrid
ACD BioGRID TRIM55 GeneID BioGRID Two-hybrid
ACD BioGRID NTAQ1 GeneID BioGRID Two-hybrid
ACD BioGRID H4C1 GeneID BioGRID Affinity Capture-MS
ACD BioGRID BRCA1 GeneID BioGRID Proximity Label-MS
ACD BioGRID MDC1 GeneID BioGRID Proximity Label-MS
ACD BioGRID TP53BP1 GeneID BioGRID Proximity Label-MS
ACD BioGRID EGLN3 GeneID BioGRID Affinity Capture-MS
ACD BioGRID IGHG2 GeneID BioGRID Affinity Capture-MS
ACD BioGRID USP7 GeneID BioGRID Affinity Capture-MS; Two-hybrid
ACD BioGRID Terf1 GeneID BioGRID Affinity Capture-MS
ACD BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
ACD BioGRID ANXA8L1 GeneID BioGRID Two-hybrid
ACD BioGRID CUL5 GeneID BioGRID Affinity Capture-MS
ACD BioGRID ZNF790 GeneID BioGRID Two-hybrid
ACD BioGRID PAGE2 GeneID BioGRID Two-hybrid
ACD BioGRID APOBEC3F GeneID BioGRID Two-hybrid
ACD BioGRID NUDCD2 GeneID BioGRID Two-hybrid
ACD BioGRID LRRC25 GeneID BioGRID Two-hybrid
ACD BioGRID TRIM15 GeneID BioGRID Two-hybrid
ACD BioGRID AFAP1L2 GeneID BioGRID Two-hybrid
ACD BioGRID TBC1D10A GeneID BioGRID Two-hybrid
ACD BioGRID PDLIM2 GeneID BioGRID Two-hybrid
ACD BioGRID RBKS GeneID BioGRID Two-hybrid
ACD BioGRID ANKMY2 GeneID BioGRID Two-hybrid
ACD BioGRID PGM2 GeneID BioGRID Two-hybrid
ACD BioGRID SBDS GeneID BioGRID Two-hybrid
ACD BioGRID LGALSL GeneID BioGRID Two-hybrid
ACD BioGRID DBNL GeneID BioGRID Two-hybrid
ACD BioGRID AIPL1 GeneID BioGRID Two-hybrid
ACD BioGRID NCDN GeneID BioGRID Two-hybrid
ACD BioGRID STIP1 GeneID BioGRID Two-hybrid
ACD BioGRID TOMM34 GeneID BioGRID Two-hybrid
ACD BioGRID NUDC GeneID BioGRID Two-hybrid
ACD BioGRID TRIM16 GeneID BioGRID Two-hybrid
ACD BioGRID TUBB4B GeneID BioGRID Two-hybrid
ACD BioGRID STUB1 GeneID BioGRID Two-hybrid
ACD BioGRID FAM131B GeneID BioGRID Two-hybrid
ACD BioGRID BAG3 GeneID BioGRID Two-hybrid
ACD BioGRID RECQL4 GeneID BioGRID Two-hybrid
ACD BioGRID EIF3G GeneID BioGRID Two-hybrid
ACD BioGRID FKBP6 GeneID BioGRID Two-hybrid
ACD BioGRID YWHAE GeneID BioGRID Two-hybrid
ACD BioGRID TUBB2A GeneID BioGRID Two-hybrid
ACD BioGRID TBCD GeneID BioGRID Two-hybrid
ACD BioGRID TAGLN GeneID BioGRID Two-hybrid
ACD BioGRID SULT1C2 GeneID BioGRID Two-hybrid
ACD BioGRID RGS3 GeneID BioGRID Two-hybrid
ACD BioGRID PEX5 GeneID BioGRID Two-hybrid
ACD BioGRID PFKP GeneID BioGRID Two-hybrid
ACD BioGRID LDHA GeneID BioGRID Two-hybrid
ACD BioGRID LASP1 GeneID BioGRID Two-hybrid
ACD BioGRID RPSA GeneID BioGRID Two-hybrid
ACD BioGRID IPO5 GeneID BioGRID Two-hybrid
ACD BioGRID IVL GeneID BioGRID Two-hybrid
ACD BioGRID HSP90AB1 GeneID BioGRID Two-hybrid
ACD BioGRID GAPDH GeneID BioGRID Two-hybrid
ACD BioGRID ENSA GeneID BioGRID Two-hybrid
ACD BioGRID ENO2 GeneID BioGRID Two-hybrid
ACD BioGRID CTTN GeneID BioGRID Two-hybrid
ACD BioGRID EIF4B GeneID BioGRID Two-hybrid
ACD BioGRID DPYSL3 GeneID BioGRID Two-hybrid
ACD BioGRID DCX GeneID BioGRID Two-hybrid
ACD BioGRID DBN1 GeneID BioGRID Two-hybrid
ACD BioGRID CKB GeneID BioGRID Two-hybrid
ACD BioGRID ZFP36L1 GeneID BioGRID Two-hybrid
ACD BioGRID ADPRH GeneID BioGRID Two-hybrid
ACD BioGRID ACTB GeneID BioGRID Two-hybrid
ACD BioGRID TERF2 GeneID BioGRID Affinity Capture-Western
ACD Protein TINF2 GeneID HPRD
ACD Protein POT1 GeneID HPRD
ACD Protein USP7 GeneID HPRD
ACD Protein LLGL1 GeneID HPRD
ACD Protein XRCC6 GeneID HPRD
ACD BioGRID XRCC6 GeneID BioGRID Two-hybrid
ACD Protein POT1 GeneID BIND PTOP interacts with POT1.
ACD Protein TINF2 GeneID BIND PTOP interacts with TIN2.
StringDB
A B experiments database textmining combined score hadb nhadb
ACD TYRP1 0 0 57 196 1 1
ACD DCLRE1B 0 900 374 937 1 1
ACD STAG2 0 600 0 600 1 1
ACD TERT 270 600 788 932 1 2
ACD H2AFZ 0 600 0 600 1 1
ACD HNMT 0 0 0 351 1 1
ACD HIST2H2AC 0 600 54 605 1 1
ACD GZMM 0 0 383 383 1 1
ACD RAD50 0 650 45 651 1 1
ACD HSP90AB1 295 0 0 295 1 2
ACD EMC3 0 0 167 167 1 1
ACD PDLIM2 295 0 0 295 1 1
ACD MTR 0 0 181 181 1 1
ACD CCDC79 0 360 181 453 1 1
ACD TERF2 675 900 721 990 1 1
ACD POLA1 0 600 0 600 1 1
ACD PIGA 0 0 0 191 1 1
ACD ITM2A 0 0 112 173 1 1
ACD NBN 0 650 90 667 1 1
ACD NUDC 295 0 0 310 1 1
ACD ENSA 295 0 0 295 1 1
ACD ENO2 295 0 0 295 1 1
ACD STK39 0 0 0 167 1 1
ACD HIST1H2BN 0 600 0 600 1 1
ACD LIG1 0 900 0 907 1 1
ACD CHTF18 0 600 0 615 1 1
ACD WRAP53 0 600 460 780 1 1
ACD MN1 0 0 108 436 1 1
ACD DMXL1 0 0 337 337 1 1
ACD GAR1 0 600 393 774 1 1
ACD TAGLN 295 0 0 295 1 1
ACD NEIL3 0 600 0 600 1 1
ACD RPA3 0 600 134 638 1 1
ACD PDE11A 0 0 134 223 1 1
ACD RUVBL1 0 0 143 214 1 1
ACD NOP10 0 600 505 793 1 1
ACD PEX5 295 0 0 295 1 1
ACD RLTPR 0 0 151 176 1 1
ACD TNKS1BP1 0 0 153 283 1 1
ACD HIST1H2AD 0 600 0 600 1 1
ACD SBDS 295 0 105 434 1 1
ACD TP53BP1 405 0 276 550 1 1
ACD CES4A 0 0 170 169 1 1
ACD CD163L1 0 0 57 226 1 1
ACD DNMT3B 0 0 91 162 1 1
ACD LMNB1 0 600 82 617 1 1
ACD ELMO3 0 0 242 294 1 1
ACD SLX4 0 0 231 239 1 1
ACD ZFP36L1 295 0 0 295 1 1
ACD CHEK2 0 0 172 171 1 1
ACD EXOC3L1 0 0 325 377 1 1
ACD CIAO1 0 0 150 381 1 1
ACD SYNE2 0 600 0 600 1 1
ACD RBKS 295 0 0 295 1 1
ACD DUS2 0 0 189 254 1 1
ACD ANKMY2 295 0 0 295 1 1
ACD POMC 0 0 125 228 1 1
ACD HIST1H2BA 0 600 0 600 1 1
ACD POLD1 0 600 0 622 1 1
ACD TRIM55 192 0 0 192 1 1
ACD DPYSL3 295 0 0 295 1 1
ACD HIST1H2AC 0 600 0 600 1 1
ACD POLD2 0 600 0 614 1 1
ACD PIF1 0 900 83 904 1 1
ACD KCTD19 0 0 260 296 1 1
ACD ATRX 0 600 146 643 1 1
ACD WNT3A 0 0 385 384 1 2
ACD GAPDH 295 0 203 428 1 2
ACD STAG3 0 600 0 600 1 1
ACD KCNH8 0 0 0 245 1 1
ACD CTC1 0 720 628 891 1 1
ACD CYP1A1 0 0 0 474 1 2
ACD CYP2A7 0 0 0 173 1 1
ACD PCNA 0 600 0 600 1 2
ACD OBFC1 295 720 500 907 1 1
ACD MC1R 0 0 270 271 1 1
ACD CYP1B1 0 0 0 219 1 1
ACD SMC1B 0 600 0 600 1 1
ACD ACSF3 0 0 0 294 1 1
ACD APOBEC3F 295 0 0 295 1 1
ACD H2AFJ 0 600 0 600 1 1
ACD PRIM2 0 600 0 608 1 1
ACD MTFP1 0 0 113 157 1 1
ACD ANXA8L1 192 0 0 192 1 1
ACD POLD3 0 600 0 600 1 1
ACD LGALSL 295 0 0 295 1 1
ACD WDR54 0 0 129 168 1 1
ACD DCX 295 0 0 295 1 1
ACD CYP4V2 0 0 504 504 1 1
ACD DSCC1 0 600 0 600 1 1
ACD TUBB2A 295 0 0 295 1 1
ACD DDX28 0 0 163 216 1 1
ACD TERF1 870 900 981 999 1 1
ACD MMS19 0 0 120 272 1 1
ACD ALB 0 0 136 163 1 2
ACD PLN 0 0 108 188 1 1
ACD SUN2 0 600 0 600 1 1
ACD HIST1H2BJ 0 600 0 600 1 1
ACD BAG3 295 0 0 295 1 2
ACD AIPL1 295 0 0 295 1 1
ACD FAM20A 0 0 161 161 1 1
ACD REC8 0 600 0 600 1 1
ACD CCNA1 0 900 0 900 1 1
ACD MC2R 0 0 155 154 1 1
ACD RTEL1 0 600 426 765 1 1
ACD ANXA8 295 0 0 295 1 1
ACD CHTF8 0 600 0 600 1 1
ACD LDHA 295 0 0 295 1 2
ACD DBN1 295 0 0 312 1 1
ACD H2BFS 0 600 0 600 1 1
ACD PRIM1 0 600 0 600 1 1
ACD HCFC1 0 0 0 216 1 1
ACD IPO5 295 0 0 295 1 1
ACD YARS2 0 0 181 181 1 1
ACD C9orf142 0 0 0 153 1 1
ACD H2AFV 0 600 0 600 1 1
ACD CDK2 0 900 0 900 1 2
ACD FKBP6 295 0 0 295 1 1
ACD RANBP10 0 0 181 214 1 1
ACD TBC1D10A 295 0 0 295 1 1
ACD USP7 247 0 0 246 1 1
ACD CTNNB1 0 0 391 429 1 2
ACD LEF1 0 0 182 187 1 1
ACD LIG3 0 0 175 175 1 1
ACD ATM 0 0 367 367 1 2
ACD CD163 0 0 0 213 1 1
ACD PWP1 0 0 397 397 1 1
ACD ADPRH 295 0 0 295 1 1
ACD CDH1 0 0 124 178 1 2
ACD MRE11A 0 650 0 650 1 1
ACD ALCAM 0 0 0 188 1 1
ACD RAD51 0 0 134 168 1 2
ACD AXIN1 0 0 148 179 1 1
ACD TRIM63 192 0 0 192 1 1
ACD PINX1 0 0 626 626 1 1
ACD XRCC2 0 0 70 227 1 1
ACD DKC1 0 600 469 778 1 1
ACD HIST1H4F 270 0 60 284 1 1
ACD HIST1H2BO 0 600 0 600 1 1
ACD ERCC4 0 0 113 206 1 1
ACD SUN1 0 600 74 613 1 1
ACD TRIM28 0 0 0 179 1 2
ACD RECQL4 295 0 167 435 1 1
ACD PDS5A 0 0 0 240 1 1
ACD PDS5B 0 0 85 487 1 1
ACD H2AFX 0 600 146 656 1 1
ACD ECD 0 0 0 642 1 2
ACD DBNL 295 0 0 310 1 1
ACD CBX3 0 0 156 155 1 1
ACD TERF2IP 870 900 843 997 1 1
ACD SNRPA 0 0 0 204 1 1
ACD XRCC4 0 0 108 162 1 1
ACD HNF4A 0 0 460 460 1 1
ACD CKB 295 0 0 295 1 1
ACD RNF8 0 0 150 203 1 1
ACD HIST2H2BE 0 600 73 613 1 1
ACD LRRC25 295 0 0 295 1 1
ACD PRKDC 0 0 181 181 1 2
ACD TINF2 911 900 986 999 1 1
ACD H2AFB1 0 600 0 600 1 1
ACD IVL 295 0 0 295 1 1
ACD TOMM34 295 0 0 295 1 1
ACD PEPD 0 0 151 150 1 1
ACD HIST3H3 0 600 46 602 1 1
ACD TRIM31 0 0 246 245 1 1
ACD MAOA 0 0 0 254 1 1
ACD TRIM16 295 0 0 295 1 2
ACD FEN1 0 900 170 916 1 1
ACD TP53 0 0 283 298 1 2
ACD AFAP1L2 295 0 55 305 1 1
ACD KDM1A 0 0 54 158 1 2
ACD ZFP90 0 0 155 173 1 1
ACD GTF2E1 0 0 180 179 1 1
ACD CD5L 0 0 0 260 1 1
ACD HIST1H2BL 0 600 0 600 1 1
ACD TRIM15 295 0 0 295 1 1
ACD PRPF19 0 0 95 154 1 1
ACD ADAT2 0 0 126 191 1 1
ACD FHOD1 0 0 139 171 1 1
ACD CCND1 0 0 235 235 1 2
ACD ZNF790 295 0 0 295 1 1
ACD FGF8 0 0 384 384 1 1
ACD FGF7 0 0 82 280 1 1
ACD XRCC5 0 720 211 769 1 1
ACD CDKN2A 0 0 150 169 1 2
ACD PPP6C 0 900 0 900 1 1
ACD ERCC1 0 0 180 179 1 1
ACD LMNA 0 600 74 613 1 2
ACD EXO1 0 0 161 161 1 1
ACD ZSCAN22 0 0 105 199 1 1
ACD RPS27A 270 0 0 270 1 1
ACD ACSL6 0 0 158 165 1 1
ACD UNCX 0 0 124 313 1 1
ACD MCM5 0 0 0 151 1 1
ACD BLM 0 900 276 924 1 2
ACD ARMC5 0 0 166 252 1 1
ACD TIMELESS 0 0 183 213 1 1
ACD OXSR1 0 0 48 174 1 1
ACD ACR 0 0 193 516 1 1
ACD FAM131B 295 0 0 295 1 1
ACD DLG3 0 0 0 258 1 1
ACD CENPT 0 0 112 189 1 1
ACD RAD21 0 600 46 602 1 1
ACD KCNH3 0 0 150 607 1 1
ACD SULT1C2 295 0 0 295 1 1
ACD ACTB 295 0 193 418 1 2
ACD PARN 0 0 164 185 1 1
ACD STUB1 295 0 0 312 1 2
ACD CTTN 295 0 0 295 1 1
ACD RPA1 0 600 180 665 1 1
ACD PLEKHG4 0 0 157 241 1 1
ACD WRN 0 900 398 937 1 1
ACD ACSBG1 0 0 0 189 1 1
ACD RPSA 295 0 0 295 1 1
ACD HPD 0 0 180 179 1 1
ACD EIF4B 295 0 0 295 1 1
ACD DAXX 0 600 113 641 1 1
ACD RFC3 0 600 0 608 1 1
ACD KCNH4 0 0 0 245 1 1
ACD TMED6 0 0 240 292 1 1
ACD RFC4 0 600 0 608 1 1
ACD C15orf43 0 0 232 231 1 1
ACD LRP6 0 0 120 156 1 1
ACD LASP1 295 0 0 299 1 1
ACD HOXD13 0 0 85 181 1 1
ACD SYCP3 0 600 0 600 1 1
ACD POLA2 0 600 0 600 1 1
ACD POT1 997 900 884 999 1 1
ACD NCDN 295 0 0 295 1 1
ACD TBCD 295 0 0 310 1 1
ACD XRCC6 0 720 276 788 1 1
ACD TEN1 0 720 710 919 1 1
ACD RFC5 0 600 0 608 1 1
ACD NUDCD2 295 0 0 295 1 1
ACD HIST1H2BD 0 600 0 600 1 1
ACD ANKRD28 0 900 0 900 1 1
ACD CD72 0 0 0 161 1 1
ACD KIF2C 0 0 180 179 1 1
ACD TUBB4B 295 0 0 312 1 1
ACD MPP3 0 0 171 687 1 1
ACD SYCP2 0 600 0 600 1 1
ACD DCT 0 0 61 376 1 1
ACD SCD5 0 0 89 187 1 1
ACD MMP3 0 0 66 164 1 1
ACD NHP2 0 600 502 792 1 1
ACD MYC 0 0 266 279 1 2
ACD POLD4 0 600 0 600 1 1
ACD DAAM2 0 0 123 279 1 1
ACD STAG1 0 600 83 617 1 1
ACD TNKS 0 0 505 505 1 1
ACD ERCC3 0 0 74 171 1 1
ACD RGS3 295 0 0 295 1 1
ACD RFC2 0 600 57 615 1 1
ACD USB1 0 0 261 432 1 1
ACD HIST1H2BB 0 600 0 600 1 1
ACD RUVBL2 0 0 143 217 1 1
ACD PFKP 295 0 0 313 1 1
ACD TK1 0 0 67 160 1 1
ACD CCNA2 0 900 0 900 1 1
ACD STIP1 295 0 0 295 1 1
ACD CHEK1 0 0 157 156 1 2
ACD MEN1 0 0 90 151 1 1
ACD ANO1 0 0 164 224 1 1
ACD CYP2A13 0 0 0 173 1 1
ACD PPP6R3 0 900 0 902 1 1
ACD PGM2 295 0 0 295 1 1
ACD HIST1H2BH 0 600 0 600 1 1
ACD AXIN2 0 0 233 266 1 1
ACD PLA2G15 0 0 120 163 1 1
ACD ARX 0 0 108 171 1 1
ACD COIL 0 0 124 196 1 2
ACD DMBT1 0 0 0 213 1 1
ACD MDC1 405 0 183 493 1 1
ACD RPA2 0 600 48 621 1 1
ACD CYP2A6 0 0 0 173 1 1
ACD RPUSD1 0 0 0 151 1 1
ACD ACRC 0 0 162 161 1 1
ACD HIST1H2BK 0 600 0 600 1 1
ACD DLL1 0 0 430 430 1 1
ACD LRP5 0 0 180 179 1 1
ACD ZNRF3 0 0 158 222 1 1
ACD UPF1 270 0 150 376 1 1
ACD NUPR1L 0 0 567 567 1 1
ACD HIST1H2BM 0 600 0 600 1 1
ACD POR 0 0 0 539 1 2
ACD PAGE2 295 0 0 295 1 1
ACD SHH 0 0 91 153 1 2
ACD SMC1A 0 600 0 600 1 1
ACD SMC3 0 600 0 600 1 1
ACD PARD6A 0 0 113 172 1 1
ACD HMBOX1 0 0 161 289 1 1
ACD C11orf85 0 0 240 239 1 1
ACD HIST1H2AJ 0 600 0 600 1 1
ACD BRCA1 405 0 82 430 1 2
ACD CD6 0 0 0 356 1 1
ACD DNA2 0 600 162 661 1 1
ACD ATF7IP 0 0 107 246 1 1
ACD ACSBG2 0 0 0 156 1 1
ACD YWHAE 295 0 0 295 1 1
ACD GLTSCR2 0 0 166 180 1 1
ACD EIF3G 295 0 0 321 1 1
ACD RFC1 0 600 0 600 1 1
ACD FAM96B 0 0 163 220 1 1
ACD SYNE1 0 600 0 600 1 1
ACD DCLRE1C 0 0 95 155 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0070182 Molecular Function DNA polymerase binding enables IPI
GO:0070182 Molecular Function DNA polymerase binding enables TAS
GO:0005515 Molecular Function protein binding enables IPI
GO:0044877 Molecular Function protein-containing complex binding enables IPI
GO:0042162 Molecular Function telomeric DNA binding enables IBA
GO:0042162 Molecular Function telomeric DNA binding enables IDA
GO:0030326 Biological Process embryonic limb morphogenesis involved_in IEA
GO:0070200 Biological Process establishment of protein localization to telomere involved_in IMP
GO:0070200 Biological Process establishment of protein localization to telomere involved_in TAS
GO:0006886 Biological Process intracellular protein transport involved_in IMP
GO:0032211 Biological Process negative regulation of telomere maintenance via telomerase involved_in IBA
GO:0032211 Biological Process negative regulation of telomere maintenance via telomerase involved_in IGI
GO:0032211 Biological Process negative regulation of telomere maintenance via telomerase involved_in IMP
GO:0032211 Biological Process negative regulation of telomere maintenance via telomerase involved_in TAS
GO:0060381 Biological Process positive regulation of single-stranded telomeric DNA binding involved_in IDA
GO:0051973 Biological Process positive regulation of telomerase activity involved_in IBA
GO:0051973 Biological Process positive regulation of telomerase activity involved_in IDA
GO:0032206 Biological Process positive regulation of telomere maintenance involved_in NAS
GO:0032212 Biological Process positive regulation of telomere maintenance via telomerase involved_in IDA
GO:0031848 Biological Process protection from non-homologous end joining at telomere involved_in ISS
GO:0070198 Biological Process protein localization to chromosome, telomeric region involved_in IBA
GO:0070198 Biological Process protein localization to chromosome, telomeric region involved_in IDA
GO:0070198 Biological Process protein localization to chromosome, telomeric region involved_in IMP
GO:0035282 Biological Process segmentation involved_in IEA
GO:0001501 Biological Process skeletal system development involved_in IEA
GO:0032202 Biological Process telomere assembly involved_in IMP
GO:0016233 Biological Process telomere capping involved_in IBA
GO:0016233 Biological Process telomere capping involved_in IDA
GO:0016233 Biological Process telomere capping involved_in IGI
GO:0016233 Biological Process telomere capping involved_in NAS
GO:0016233 Biological Process telomere capping involved_in TAS
GO:0000723 Biological Process telomere maintenance acts_upstream_of_or_within IDA
GO:0007004 Biological Process telomere maintenance via telomerase involved_in IEA
GO:0001655 Biological Process urogenital system development involved_in IEA
GO:0000781 Cellular Component chromosome, telomeric region located_in HDA
GO:0000781 Cellular Component chromosome, telomeric region located_in IDA
GO:0016604 Cellular Component nuclear body located_in IDA
GO:0000783 Cellular Component nuclear telomere cap complex part_of IDA
GO:0005654 Cellular Component nucleoplasm located_in TAS
GO:0070187 Cellular Component shelterin complex part_of IBA
GO:0070187 Cellular Component shelterin complex part_of IDA
GO:0070187 Cellular Component shelterin complex part_of IMP
GO:0070187 Cellular Component shelterin complex part_of IPI
GO:0070187 Cellular Component shelterin complex part_of TAS
GO:0005697 Cellular Component telomerase holoenzyme complex part_of IEA
Pathways
Name DB ID
Recognition and association of DNA glycosylase with site containing an affected pyrimidine Reactome R-HSA-110328
Cleavage of the damaged pyrimidine Reactome R-HSA-110329
Recognition and association of DNA glycosylase with site containing an affected purine Reactome R-HSA-110330
Cleavage of the damaged purine Reactome R-HSA-110331
Meiotic synapsis Reactome R-HSA-1221632
Reproduction Reactome R-HSA-1474165
Meiosis Reactome R-HSA-1500620
Telomere Maintenance Reactome R-HSA-157579
Cell Cycle Reactome R-HSA-1640170
Packaging Of Telomere Ends Reactome R-HSA-171306
Telomere Extension By Telomerase Reactome R-HSA-171319
Polymerase switching on the C-strand of the telomere Reactome R-HSA-174411
Processive synthesis on the C-strand of the telomere Reactome R-HSA-174414
Telomere C-strand (Lagging Strand) Synthesis Reactome R-HSA-174417
Telomere C-strand synthesis initiation Reactome R-HSA-174430
Removal of the Flap Intermediate from the C-strand Reactome R-HSA-174437
Extension of Telomeres Reactome R-HSA-180786
Cellular responses to stress Reactome R-HSA-2262752
Cellular Senescence Reactome R-HSA-2559583
DNA Damage/Telomere Stress Induced Senescence Reactome R-HSA-2559586
Base Excision Repair Reactome R-HSA-73884
Chromosome Maintenance Reactome R-HSA-73886
DNA Repair Reactome R-HSA-73894
Depurination Reactome R-HSA-73927
Depyrimidination Reactome R-HSA-73928
Base-Excision Repair, AP Site Formation Reactome R-HSA-73929
Cellular responses to stimuli Reactome R-HSA-8953897
Inhibition of DNA recombination at telomere Reactome R-HSA-9670095
Transcripts
Accession Version MolecularType Name NCBI Comments
XR_429728 4 miscRNA transcript variant X1 NC_000016 Reference
NM_022914 3 mRNA transcript variant 2 NC_000016 Reference
NM_001410884 1 mRNA transcript variant 3 NC_000016 Reference
NM_001082486 2 mRNA transcript variant 1 NC_000016 Reference