HAdb 2.0 is available now!

TH

tyrosine hydroxylase
General Information
Name tyrosine hydroxylase
Alias
  • tyrosine 3-monooxygenase
  • dystonia 14
  • tyrosine 3-hydroxylase
Gene_family
organism Homo sapiens
entrez_id 7054
location 11p15.5
transcript_count 4
exon_count 14
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
    Stringdb Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family
    nextProt Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:17391063, PubMed:1680128, PubMed:15287903, PubMed:8528210, Ref.18, PubMed:34922205, PubMed:24753243). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
TH BioGRID YWHAZ GeneID BioGRID Reconstituted Complex
TH BioGRID RELL1 GeneID BioGRID Affinity Capture-MS
TH BioGRID ZBTB34 GeneID BioGRID Affinity Capture-MS
TH BioGRID MTFR2 GeneID BioGRID Affinity Capture-MS
TH BioGRID DNAJC12 GeneID BioGRID Affinity Capture-MS
TH BioGRID KDM3B GeneID BioGRID Affinity Capture-MS
TH BioGRID TAOK2 GeneID BioGRID Affinity Capture-MS
TH BioGRID MAP3K7 GeneID BioGRID Affinity Capture-MS
TH BioGRID NFIC GeneID BioGRID Affinity Capture-MS; Two-hybrid
TH BioGRID CUL4A GeneID BioGRID Affinity Capture-MS
TH BioGRID CRABP1 GeneID BioGRID Two-hybrid
TH BioGRID UMAD1 GeneID BioGRID Two-hybrid
TH BioGRID ZNF569 GeneID BioGRID Two-hybrid
TH BioGRID DAAM2 GeneID BioGRID Two-hybrid
TH BioGRID TSPYL4 GeneID BioGRID Two-hybrid
TH BioGRID PUF60 GeneID BioGRID Two-hybrid
TH BioGRID PIAS2 GeneID BioGRID Two-hybrid
TH BioGRID TH GeneID BioGRID Two-hybrid
TH BioGRID RBMY1A1 GeneID BioGRID Two-hybrid
TH BioGRID MDFI GeneID BioGRID Two-hybrid
TH BioGRID HNRNPK GeneID BioGRID Two-hybrid
TH BioGRID Nr4a1 GeneID BioGRID Co-localization
TH BioGRID H3-3A GeneID BioGRID Co-localization
TH BioGRID FGFR1 GeneID BioGRID Co-localization
TH BioGRID CREBBP GeneID BioGRID Co-localization
TH BioGRID TAB1 GeneID BioGRID Affinity Capture-MS
TH BioGRID TYSND1 GeneID BioGRID Biochemical Activity
TH BioGRID YWHAQ GeneID BioGRID Affinity Capture-MS
TH Protein MAPKAPK2 GeneID HPRD
TH Protein CDK11B GeneID HPRD
TH Protein RPS6KA5 GeneID HPRD
TH Protein CAMK2G GeneID HPRD
TH Protein MAPK3 GeneID HPRD
TH Protein PRKACA GeneID HPRD
TH Protein YWHAB GeneID HPRD
TH Protein YWHAZ GeneID HPRD
TH Protein MAPK1 GeneID HPRD
TH Protein SNCA GeneID HPRD
TH Protein CSNK2A1 GeneID HPRD
TH BioGRID MAPK3 GeneID BioGRID Biochemical Activity
TH BioGRID MAPK1 GeneID BioGRID Biochemical Activity
StringDB
A B experiments database textmining combined score hadb nhadb
TH ZGLP1 0 0 0 161 1 1
TH KITLG 0 0 153 152 1 1
TH CHRNA4 0 0 142 209 1 1
TH SOX3 0 0 142 337 1 1
TH KISS1 0 0 459 459 1 1
TH ZIC1 0 0 157 156 1 1
TH ADCYAP1 0 0 519 540 1 1
TH ITPR2 0 0 0 162 1 1
TH TLR10 0 0 0 157 1 1
TH RHCE 0 0 45 157 1 1
TH TPO 0 900 183 916 1 1
TH CALY 0 0 113 169 1 1
TH CXADR 0 0 0 207 1 1
TH DNMT3B 0 0 135 154 1 1
TH MAPK8IP1 0 0 107 161 1 1
TH DNMT3A 0 0 151 150 1 2
TH TUBB4A 0 0 117 196 1 1
TH ENSG00000277666 0 0 0 207 1 1
TH BCL2L1 0 0 260 276 1 2
TH NPR1 0 0 175 191 1 1
TH KCNC1 0 0 142 160 1 1
TH HTR3A 0 0 289 304 1 1
TH SMAD2 0 0 107 167 1 2
TH CYP1A2 0 0 357 364 1 1
TH TLR4 0 0 294 318 1 2
TH SLC6A5 0 0 261 293 1 1
TH DNASE1 0 0 60 160 1 1
TH GAPDH 0 0 557 567 1 2
TH TENM4 0 0 0 156 1 1
TH METRNL 0 0 203 203 1 1
TH OLIG1 0 0 160 179 1 1
TH TRPC3 0 0 150 185 1 1
TH SLC18A3 0 0 732 788 1 1
TH RD3 0 0 44 160 1 1
TH RPS6KA5 213 0 103 263 1 1
TH GRHL1 0 0 0 302 1 1
TH NEFM 0 0 263 298 1 1
TH NOS2 0 0 232 249 1 2
TH CX3CL1 0 0 181 181 1 1
TH MAP2K7 0 0 201 201 1 1
TH NF1 0 0 261 288 1 1
TH TAAR1 0 0 242 241 1 1
TH CDNF 0 0 577 582 1 1
TH BCL11B 0 0 309 309 1 1
TH TMEM26 0 0 156 155 1 1
TH SDHB 0 0 268 268 1 1
TH PRKACA 213 0 0 478 1 1
TH CALB2 0 0 737 798 1 1
TH PIEZO2 0 0 183 194 1 1
TH PFKL 0 0 305 305 1 1
TH CREBBP 273 0 226 421 1 1
TH MBOAT4 0 0 136 191 1 1
TH POU3F2 0 0 323 343 1 1
TH ATP1A3 0 0 316 315 1 1
TH ADCY9 0 0 70 231 1 1
TH IFNG 0 0 233 276 1 2
TH CLTCL1 0 0 0 223 1 1
TH RAPGEF3 0 0 205 205 1 1
TH CREB1 0 0 676 676 1 2
TH SDF4 0 0 404 404 1 1
TH NLGN3 0 0 134 165 1 1
TH AKR1B10 0 900 0 907 1 1
TH FGF14 0 0 66 211 1 1
TH SYT12 0 0 134 152 1 1
TH TGFB3 0 0 254 270 1 1
TH CCL5 0 0 138 162 1 2
TH MYT1L 0 0 253 273 1 1
TH GRIA2 0 0 310 371 1 1
TH FGF21 0 0 216 265 1 2
TH OPN5 0 0 227 295 1 1
TH GRIA4 0 0 316 377 1 1
TH ANXA5 0 0 182 181 1 2
TH NPPA 0 0 134 212 1 1
TH ALDH3B2 0 0 0 232 1 1
TH HSD11B2 0 0 156 166 1 1
TH RAPGEF4 0 0 176 175 1 1
TH NRG2 0 0 74 326 1 1
TH TRPC1 0 0 218 218 1 1
TH GJD2 0 0 218 235 1 1
TH RGS4 0 0 233 249 1 1
TH GRIK2 0 0 162 190 1 1
TH SC5D 0 0 0 195 1 1
TH SERPINI1 0 0 44 152 1 1
TH SIRT2 0 0 229 256 1 2
TH EPO 0 0 335 336 1 2
TH PLEC 0 0 0 362 1 1
TH METRN 0 0 157 156 1 1
TH ABAT 0 0 170 231 1 1
TH RELN 0 0 310 337 1 1
TH PPAPDC1A 0 0 43 175 1 1
TH PSEN2 0 0 159 169 1 1
TH FGF13 0 0 339 339 1 1
TH CXCR4 0 0 218 218 1 2
TH L1CAM 0 0 157 218 1 1
TH NOTCH1 0 0 265 272 1 2
TH GABRB2 0 0 113 181 1 1
TH GABRA1 0 0 143 214 1 1
TH TBR1 0 0 360 374 1 1
TH MTOR 0 0 282 283 1 2
TH SYT7 0 0 161 208 1 1
TH SORT1 0 0 181 193 1 1
TH FAHD2B 0 0 0 192 1 1
TH MRRF 0 0 497 535 1 1
TH POTEF 0 0 218 297 1 1
TH MPO 0 0 204 204 1 2
TH PRKG1 0 0 146 218 1 1
TH UCP2 0 0 269 285 1 2
TH GRM7 0 0 157 197 1 1
TH IL6 0 0 469 502 1 2
TH NPAS2 0 0 247 246 1 1
TH CTRL 0 0 155 154 1 2
TH GPR37 0 0 252 252 1 1
TH POU4F2 0 0 231 251 1 1
TH STAT1 0 0 120 153 1 2
TH ELAVL3 0 0 464 511 1 1
TH GRM8 0 0 113 221 1 1
TH KCNMA1 0 0 143 193 1 1
TH OCLN 0 0 137 155 1 1
TH KCNJ9 0 0 140 158 1 1
TH TNFRSF1A 0 0 193 193 1 1
TH ALDH3B1 0 0 0 158 1 1
TH HIF1A 0 0 324 323 1 2
TH EDN1 0 0 287 286 1 1
TH SMAD9 0 0 45 165 1 1
TH EN2 0 0 320 384 1 1
TH SIRT5 0 0 164 163 1 1
TH SYNPR 0 0 123 195 1 1
TH ISL1 0 0 420 489 1 1
TH DBX1 0 0 172 209 1 1
TH ENSG00000267335 0 0 0 190 1 1
TH IL1B 0 0 518 521 1 2
TH PSMC2 0 0 0 210 1 1
TH ANKRD23 0 0 137 151 1 1
TH UCN2 0 0 216 216 1 1
TH SP1 0 0 157 156 1 2
TH CHRNA6 0 0 166 202 1 1
TH NKX6-2 0 0 261 274 1 1
TH CXCL8 0 0 184 183 1 2
TH PAX2 0 0 240 246 1 1
TH NDUFS4 0 0 184 213 1 1
TH GBX2 0 0 246 265 1 1
TH SLC1A7 0 0 235 244 1 1
TH CTNNB1 0 0 305 320 1 2
TH HRAS 0 0 142 214 1 2
TH MYF5 0 0 116 170 1 1
TH MAP1LC3A 0 0 82 161 1 2
TH LIPE 0 0 218 240 1 1
TH TRPV1 0 0 460 481 1 2
TH APP 0 0 466 510 1 2
TH MFN2 0 0 204 253 1 2
TH EGR1 0 0 346 369 1 2
TH SLC5A7 0 0 212 261 1 1
TH CRHBP 0 0 174 225 1 1
TH RHO 0 0 320 319 1 2
TH PSAT1 0 0 0 165 1 1
TH HCN4 0 0 234 250 1 1
TH CACNA1C 0 0 305 318 1 1
TH DNM3 0 0 0 153 1 1
TH ARC 0 0 156 157 1 2
TH KIRREL2 0 0 113 150 1 1
TH VIPR2 0 0 261 277 1 1
TH TENM2 0 0 0 206 1 1
TH JAK2 0 0 157 156 1 2
TH SEMA3C 0 0 241 240 1 1
TH EMX2 0 0 181 228 1 1
TH GHRL 0 0 450 450 1 1
TH SLC7A4 0 0 167 216 1 1
TH CACNA1D 0 0 265 279 1 1
TH CHRNA3 0 0 118 199 1 1
TH CDH2 0 0 140 159 1 1
TH HDAC6 0 0 126 172 1 2
TH APAF1 0 0 134 151 1 2
TH BHLHE22 0 0 166 191 1 1
TH CTBP2 0 0 184 194 1 1
TH SEMA3D 0 0 195 195 1 1
TH CHGB 0 0 269 286 1 1
TH ADCY1 0 0 112 156 1 1
TH VGF 0 0 283 319 1 1
TH NR4A1 0 0 343 351 1 2
TH KCND3 0 0 150 228 1 1
TH CHRFAM7A 0 0 0 156 1 1
TH GSX2 0 0 248 254 1 1
TH PCSK5 0 0 157 179 1 1
TH ERN1 0 0 163 163 1 2
TH SLC22A3 0 0 195 213 1 1
TH GCLM 0 0 145 165 1 1
TH NR2F1 0 0 143 160 1 1
TH ELAVL2 0 0 253 319 1 1
TH GATA3 0 0 235 431 1 1
TH SEMA3B 0 0 210 210 1 1
TH PTN 0 0 218 218 1 1
TH CD300C 0 0 183 194 1 1
TH GDNF 0 0 800 820 1 2
TH STAT3 0 0 283 290 1 2
TH GART 0 0 0 351 1 1
TH TXNL1 0 0 0 169 1 1
TH MAOA 0 0 666 675 1 1
TH SLC12A5 0 0 169 187 1 1
TH TP53 0 0 335 338 1 2
TH HMBS 0 0 181 210 1 1
TH SATB2 0 0 188 193 1 1
TH SCN10A 0 0 253 283 1 1
TH CHCHD2 0 0 134 188 1 1
TH LAMP1 0 0 150 227 1 2
TH LHX1 0 0 193 230 1 1
TH SLC2A1 0 0 209 248 1 2
TH HOXB4 0 0 124 150 1 1
TH TOR1A 0 0 369 380 1 1
TH HTT 0 0 452 510 1 2
TH MYD88 0 0 125 163 1 2
TH ADORA3 0 0 270 270 1 1
TH EGFR 0 0 238 260 1 2
TH SLC2A2 0 0 122 167 1 1
TH HPDL 0 0 0 340 1 1
TH LMX1B 0 0 524 655 1 1
TH P2RX4 0 0 210 210 1 1
TH CSF3 0 0 156 214 1 1
TH NTSR1 0 0 301 316 1 1
TH EDN3 0 0 155 169 1 1
TH KIAA0753 0 0 371 371 1 1
TH FGF7 0 0 57 191 1 1
TH SKOR1 0 0 108 169 1 1
TH TNS3 0 0 168 167 1 1
TH PPP2R5D 0 900 139 910 1 1
TH PAM 0 0 188 205 1 1
TH HDAC2 0 0 160 181 1 1
TH DDIT3 0 0 163 163 1 2
TH EMX1 0 0 297 338 1 1
TH PRKX 0 0 0 276 1 1
TH CD200R1 0 0 151 150 1 1
TH LINGO1 0 0 416 439 1 1
TH NPW 0 0 150 280 1 1
TH TNNT3 0 0 57 329 1 1
TH FAHD2A 0 0 0 192 1 1
TH PLP1 0 0 150 199 1 1
TH PRKACG 0 0 0 364 1 1
TH MAP1A 0 0 150 225 1 2
TH MEF2D 0 0 212 235 1 2
TH DLX2 0 0 340 353 1 1
TH SLC2A3 0 0 151 192 1 1
TH SUCO 0 0 150 179 1 1
TH MYCN 0 0 467 476 1 1
TH LRP5 0 0 243 253 1 1
TH SLC6A1 0 0 279 308 1 1
TH SMAD4 0 0 112 178 1 2
TH HDAC5 0 0 113 151 1 1
TH AWAT2 0 0 141 160 1 1
TH CHGA 0 0 519 533 1 1
TH TDO2 0 0 123 358 1 1
TH SEMA4C 0 0 193 193 1 1
TH PARK7 0 0 729 778 1 2
TH EFNA5 0 0 138 156 1 1
TH FXN 0 0 161 167 1 1
TH NELFCD 0 0 336 336 1 1
TH SCG5 0 0 88 180 1 1
TH CEL 0 0 168 174 1 1
TH MECP2 0 0 391 390 1 1
TH NKX6-1 0 0 261 274 1 1
TH TLR1 0 0 45 160 1 1
TH RPA3OS 238 0 0 237 1 1
TH NFE2L2 0 0 320 319 1 2
TH CIDEA 0 0 217 235 1 1
TH MNX1 0 0 92 152 1 1
TH PPP1R1B 0 0 685 702 1 1
TH AKT2 0 0 90 152 1 2
TH SLC30A10 0 0 113 155 1 1
TH SYNJ1 0 0 150 173 1 1
TH GRIN3B 0 0 82 191 1 1
TH NPY 0 0 845 864 1 1
TH DYNC1I2 0 0 306 306 1 1
TH B4GALNT1 0 0 213 236 1 1
TH MAP2K1 0 0 156 157 1 1
TH FUT4 0 0 180 179 1 1
TH OPA1 0 0 236 237 1 2
TH GPR21 0 0 0 254 1 1
TH ODC1 0 0 171 201 1 1
TH GPR151 0 0 124 274 1 1
TH KISS1R 0 0 213 243 1 1
TH SLC1A3 0 0 344 368 1 1
TH MYC 0 0 361 361 1 2
TH FABP7 0 0 323 337 1 1
TH PARK2 0 0 662 776 1 1
TH FAHD1 0 0 0 192 1 1
TH CLOCK 0 0 254 267 1 2
TH WNT5A 0 0 219 233 1 2
TH SLC6A4 0 0 653 743 1 1
TH PAX7 0 0 181 195 1 1
TH HTR1B 0 0 310 328 1 1
TH LMO3 0 0 81 167 1 1
TH IGF1R 0 0 160 211 1 2
TH SDHC 0 0 205 205 1 1
TH SCARB2 0 0 70 160 1 1
TH RGS10 0 0 141 202 1 1
TH TPH1 0 0 805 207 1 1
TH BTBD9 0 0 249 314 1 1
TH PPARGC1A 0 0 403 403 1 2
TH MT3 0 0 134 171 1 1
TH SLC18A2 0 0 869 937 1 1
TH FGF10 0 0 0 188 1 1
TH TAB1 189 0 0 228 1 1
TH MAP2 0 0 661 676 1 2
TH CDS2 0 0 0 163 1 1
TH NOG 0 0 319 319 1 1
TH GPX7 0 0 0 256 1 1
TH SEMA6A 0 0 231 239 1 1
TH GNAQ 0 0 182 197 1 1
TH ADORA1 0 0 325 325 1 1
TH NTS 0 0 609 633 1 1
TH HGD 0 0 0 418 1 1
TH TMEM127 0 0 150 170 1 1
TH SYT11 0 0 167 185 1 1
TH GFRAL 0 0 115 153 1 1
TH AOC1 0 0 430 430 1 1
TH TPI1 0 0 75 217 1 1
TH SERPINA6 0 0 123 150 1 1
TH NR4A3 0 0 181 232 1 1
TH SLC1A2 0 0 401 417 1 1
TH NANOG 0 0 341 385 1 2
TH GBX1 0 0 95 158 1 1
TH CASP9 0 0 264 264 1 2
TH TBC1D15 0 0 0 207 1 1
TH CHRNA10 0 0 151 169 1 1
TH ITPR1 0 0 184 287 1 2
TH TRAF6 0 0 62 221 1 2
TH POMC 0 0 666 671 1 1
TH GNRH2 0 0 155 285 1 1
TH ALDH1L1 0 0 157 175 1 1
TH PLK2 0 0 128 212 1 1
TH CYCS 0 0 417 416 1 2
TH HNF1A 0 0 161 181 1 1
TH AKR1B1 0 900 256 927 1 1
TH CRABP1 238 0 66 274 1 1
TH IL17A 0 0 180 180 1 2
TH UCMA 0 0 112 167 1 1
TH BMP2 0 0 235 258 1 1
TH SLIT1 0 0 138 206 1 1
TH CYP27A1 0 0 202 202 1 1
TH EGF 0 0 457 464 1 2
TH ASNSD1 0 0 0 173 1 1
TH GAK 0 0 123 157 1 1
TH AGMO 0 0 183 332 1 1
TH NLRP5 0 0 358 358 1 1
TH ETV5 0 0 87 173 1 1
TH GATA4 0 0 125 305 1 2
TH LIF 0 0 372 372 1 2
TH HSPA4 0 0 320 324 1 1
TH PER3 0 0 150 203 1 1
TH LHX5 0 0 138 168 1 1
TH SNRPN 0 0 67 211 1 1
TH GCGR 0 0 108 194 1 1
TH CX3CR1 0 0 207 207 1 1
TH CLTC 0 0 0 223 1 1
TH DICER1 0 0 162 198 1 1
TH CRHR1 0 0 469 481 1 1
TH CDKN1C 0 0 202 202 1 1
TH PDE2A 0 0 108 184 1 1
TH TYR 0 900 459 943 1 2
TH GPHN 0 0 181 269 1 1
TH ZNF214 0 0 325 325 1 1
TH NES 0 0 655 687 1 2
TH TRPC6 0 0 149 154 1 1
TH CYP2E1 0 0 143 175 1 2
TH TACR3 0 0 286 301 1 1
TH CHAT 0 0 858 878 1 1
TH HSP90B1 0 0 67 210 1 1
TH VARS 0 0 0 195 1 1
TH PDE6B 0 0 123 157 1 1
TH LHX8 0 0 166 198 1 1
TH FBXO7 0 0 220 220 1 1
TH SLC8A3 0 0 95 206 1 1
TH DOPEY1 0 0 370 370 1 1
TH PPARA 0 0 246 254 1 2
TH PPY 0 0 261 261 1 1
TH TAT 0 900 170 924 1 2
TH LPL 0 0 156 197 1 1
TH CBR1 0 0 410 435 1 1
TH ACHE 0 0 665 694 1 2
TH VR1 0 0 460 481 1 1
TH GPX4 0 0 150 281 1 2
TH CSAD 0 0 60 265 1 1
TH GRM3 0 0 216 233 1 1
TH EMC3 0 0 95 151 1 1
TH HIST2H3PS2 0 0 260 266 1 1
TH NFIC 442 0 66 456 1 1
TH P2RX7 0 0 162 161 1 2
TH HES5 0 0 150 173 1 1
TH NEUROD6 0 0 218 235 1 1
TH NT5DC2 0 0 456 456 1 1
TH NR3C1 0 0 417 427 1 1
TH CORIN 0 0 151 158 1 1
TH CRHR2 0 0 373 392 1 1
TH PRNP 0 0 472 472 1 2
TH ADIPOQ 0 0 204 225 1 2
TH ARG1 0 0 203 220 1 2
TH MAPK8 0 0 212 228 1 2
TH VIM 0 0 125 175 1 2
TH MEIS2 0 0 194 200 1 1
TH DZIP1 0 0 43 187 1 1
TH CALCA 0 0 747 760 1 1
TH TRPM8 0 0 217 217 1 1
TH FOXP1 0 0 150 202 1 1
TH PSPN 0 0 293 293 1 1
TH ENO2 0 0 603 611 1 1
TH RBPMS 0 0 94 251 1 1
TH MAPKAPK2 213 900 95 922 1 1
TH YWHAG 417 0 698 823 1 1
TH NEFL 0 0 342 356 1 1
TH CHRM3 0 0 127 192 1 1
TH ALDH3A2 0 0 0 163 1 1
TH CTH 0 0 93 175 1 1
TH CP 0 0 181 245 1 1
TH NEUROG3 0 0 140 217 1 1
TH VPS35 0 0 236 259 1 2
TH FEV 0 0 123 225 1 1
TH ALCAM 0 0 96 167 1 1
TH PLG 0 0 124 201 1 1
TH FNDC5 0 0 206 206 1 1
TH BMP7 0 0 205 222 1 1
TH FGF17 0 0 82 223 1 1
TH KIAA0930 0 0 442 442 1 1
TH NEUROG2 0 0 500 512 1 1
TH SCG2 0 0 358 373 1 1
TH NR3C2 0 0 261 269 1 1
TH DPP4 0 0 146 203 1 1
TH BCHE 0 0 297 353 1 1
TH DRD2 0 0 733 858 1 1
TH AANAT 0 0 267 267 1 1
TH GATA1 0 0 91 205 1 1
TH H3F3B 273 0 52 309 1 1
TH FKBP5 0 0 181 181 1 1
TH LGALS4 0 0 468 471 1 1
TH GFRA2 0 0 134 266 1 1
TH NUP35 0 0 0 325 1 1
TH PDE4A 0 0 216 226 1 1
TH HTR5A 0 0 150 277 1 1
TH HTR7 0 0 262 278 1 1
TH DNM2 0 0 0 153 1 1
TH HTR1A 0 0 519 561 1 1
TH CABP5 0 0 129 217 1 1
TH AVP 0 0 204 266 1 1
TH MAP1B 0 0 193 294 1 2
TH IL1A 0 0 208 208 1 1
TH PAX6 0 0 519 596 1 1
TH WNT1 0 0 413 472 1 2
TH ZNF215 0 0 325 325 1 1
TH GABRB1 0 0 295 375 1 1
TH ALK 0 0 188 212 1 2
TH ROCK2 0 0 147 179 1 1
TH ABCC8 0 0 137 163 1 1
TH IAPP 0 0 181 181 1 2
TH IDO1 0 0 113 168 1 1
TH DNAJC12 129 0 0 150 1 1
TH LEPR 0 0 324 348 1 1
TH ALB 0 0 595 673 1 2
TH CASP8 0 0 182 182 1 2
TH CD68 0 0 341 356 1 2
TH SDHA 0 0 261 307 1 1
TH KNG1 0 0 245 263 1 1
TH CCL2 0 0 282 282 1 2
TH PGK1 0 0 161 213 1 2
TH ADRB3 0 0 459 459 1 1
TH PVALB 0 0 690 717 1 1
TH ITGB1 0 0 180 179 1 1
TH MOXD1 0 0 73 442 1 1
TH ELAVL1 0 0 216 281 1 2
TH NPAS1 0 0 125 157 1 1
TH CASP7 0 0 71 163 1 1
TH STMN2 0 0 283 354 1 1
TH MME 0 0 139 167 1 1
TH ADCY5 0 0 122 188 1 1
TH EP300 0 0 134 189 1 2
TH SLC17A6 0 0 686 745 1 1
TH CDK5 0 0 360 400 1 2
TH NRCAM 0 0 134 202 1 1
TH WBSCR17 0 0 66 160 1 1
TH ADRA2A 0 0 346 363 1 1
TH DDC 0 900 870 992 1 1
TH IL4 0 0 272 277 1 1
TH ADRA2B 0 0 144 197 1 1
TH HOXA2 0 0 180 186 1 1
TH CRY2 0 0 155 213 1 1
TH PPAPDC1B 0 0 0 173 1 1
TH VAMP2 0 0 294 352 1 1
TH SNCAIP 0 0 298 309 1 2
TH VSX1 0 0 122 229 1 1
TH OPRL1 0 0 210 227 1 1
TH SCT 0 0 244 245 1 1
TH MYLK 0 0 97 150 1 1
TH CDK11B 213 0 0 276 1 1
TH CNTF 0 0 470 489 1 1
TH TUBB3 0 0 460 610 1 1
TH FGF1 0 0 299 309 1 1
TH DNMT1 0 0 180 194 1 2
TH GLP1R 0 0 310 351 1 1
TH GOT1 0 900 175 926 1 1
TH NEFH 0 0 460 493 1 1
TH FOXG1 0 0 325 339 1 1
TH ENSG00000258555 0 0 400 423 1 1
TH INS 0 0 561 561 1 2
TH HOXB1 0 0 142 168 1 1
TH ACTB 0 0 601 641 1 2
TH ALDH3A1 0 0 0 157 1 1
TH SQSTM1 0 0 203 203 1 2
TH SLC11A2 0 0 323 331 1 1
TH PRLH 0 0 370 409 1 1
TH TRAM1 0 0 0 151 1 1
TH THY1 0 0 392 413 1 1
TH PROM1 0 0 181 181 1 2
TH SIRT3 0 0 193 221 1 2
TH KEAP1 0 0 232 271 1 2
TH B2M 0 0 227 255 1 1
TH MMP9 0 0 185 204 1 2
TH MAPK3 270 0 402 574 1 2
TH TMTC1 0 0 270 270 1 1
TH HDAC4 0 0 113 151 1 2
TH HPGDS 0 0 202 202 1 1
TH PNPLA2 0 0 162 161 1 2
TH HSP90AA1 0 0 448 452 1 2
TH OPN4 0 0 502 551 1 1
TH TFEB 0 0 183 183 1 2
TH COX4I1 0 0 205 210 1 1
TH CRP 0 0 150 196 1 2
TH ASS1 0 0 323 365 1 1
TH PSEN1 0 0 378 385 1 2
TH RAB29 0 0 156 164 1 1
TH CHRM1 0 0 166 201 1 1
TH HTRA2 0 0 245 262 1 1
TH SYT1 0 0 293 340 1 1
TH SOX2 0 0 456 456 1 2
TH NEUROD1 0 0 358 372 1 1
TH NKX2-4 0 0 47 199 1 1
TH P2RX2 0 0 359 359 1 1
TH ESR2 0 0 393 416 1 1
TH LMX1A 0 0 669 760 1 1
TH PTPRC 0 0 286 286 1 1
TH PMCH 0 0 82 290 1 1
TH SEMA4A 0 0 181 181 1 1
TH RAB1A 0 0 279 279 1 1
TH HBS1L 0 0 261 261 1 1
TH POU3F4 0 0 184 197 1 1
TH OCA2 0 0 86 228 1 1
TH ADORA2A 0 0 392 415 1 1
TH SLC25A14 0 0 161 161 1 1
TH FOXD3 0 0 167 185 1 1
TH ICAM1 0 0 150 203 1 2
TH NEUROG1 0 0 321 354 1 1
TH SEMA4B 0 0 193 193 1 1
TH SOX9 0 0 212 212 1 1
TH SIRT7 0 0 162 161 1 2
TH RHOA 0 0 194 194 1 2
TH PARP1 0 0 150 168 1 2
TH AR 0 0 234 242 1 2
TH GSR 0 0 297 339 1 1
TH HSPA8 0 0 180 232 1 2
TH INSR 0 0 99 154 1 1
TH GNRH1 0 0 508 512 1 1
TH VSX2 0 0 255 284 1 1
TH ECT2 0 0 0 208 1 1
TH SPR 0 900 652 968 1 1
TH SPP1 0 0 136 155 1 2
TH PHOX2A 0 0 565 619 1 1
TH SLC32A1 0 0 564 630 1 1
TH ZNF746 0 0 182 181 1 1
TH SLC18B1 0 0 0 206 1 1
TH CXCL12 0 0 232 231 1 2
TH TULP3 0 0 0 207 1 1
TH BAX 0 0 180 197 1 2
TH PYY 0 0 288 304 1 1
TH FGF4 0 0 155 240 1 1
TH CARTPT 0 0 465 465 1 1
TH TARDBP 0 0 172 173 1 2
TH SYN1 0 0 556 632 1 1
TH STX1A 0 0 194 205 1 1
TH MFN1 0 0 124 178 1 2
TH P2RY1 0 0 136 193 1 1
TH EEF1A2 0 0 271 302 1 1
TH UCHL1 0 0 658 672 1 2
TH CD8A 0 0 248 248 1 1
TH GAP43 0 0 637 644 1 1
TH IRS2 0 0 159 176 1 1
TH CALR 0 0 247 248 1 1
TH SMAD1 0 0 53 171 1 2
TH ISL2 0 0 93 190 1 1
TH SEMA3G 0 0 187 187 1 1
TH BARHL2 0 0 137 228 1 1
TH TFAM 0 0 206 265 1 2
TH ETV1 0 0 231 288 1 1
TH GRIN2D 0 0 181 287 1 1
TH RELL1 179 0 0 179 1 1
TH SEPT5 0 0 150 169 1 1
TH PRKACB 0 0 0 364 1 1
TH PENK 0 0 606 633 1 1
TH NKX2-2 0 0 290 307 1 1
TH TPH2 0 0 732 225 1 1
TH THAP1 0 0 393 392 1 1
TH GRIN2A 0 0 391 426 1 1
TH MAX 0 0 159 158 1 2
TH FYN 0 0 156 275 1 1
TH YWHAE 0 0 323 339 1 1
TH GHRH 0 0 395 403 1 1
TH VCP 0 0 92 252 1 2
TH LAMP2 0 0 123 197 1 2
TH ARNT 0 0 188 188 1 2
TH GALR2 0 0 294 304 1 1
TH BSN 0 0 242 258 1 2
TH SOD1 0 0 370 415 1 2
TH LTA 0 0 74 167 1 1
TH CDC25C 0 0 370 370 1 2
TH AASDH 0 0 0 284 1 1
TH PNMT 0 0 870 897 1 1
TH FERD3L 0 0 93 151 1 1
TH FGF6 0 0 0 190 1 1
TH SHH 0 0 581 597 1 2
TH SOX17 0 0 144 183 1 1
TH PNMA3 0 0 150 249 1 1
TH CALB1 0 0 758 814 1 1
TH GRIN2C 0 0 157 206 1 1
TH DSCAM 0 0 134 197 1 1
TH DPYSL2 0 0 181 187 1 1
TH KCNK3 0 0 142 184 1 1
TH CYP19A1 0 0 214 246 1 2
TH NPY2R 0 0 154 170 1 1
TH SCN3A 0 0 122 163 1 1
TH JUN 0 0 425 435 1 2
TH ITPR3 0 0 138 247 1 1
TH ADRA1A 0 0 193 304 1 1
TH HEPH 0 0 91 162 1 1
TH CGB 0 0 81 223 1 1
TH GRHL2 0 0 0 302 1 1
TH ALDH1A3 0 0 109 221 1 2
TH SLC25A27 0 0 166 165 1 1
TH DNTT 0 0 391 390 1 1
TH SNCA 213 800 952 992 1 2
TH NOS1 0 0 556 565 1 1
TH CASP1 0 0 182 181 1 2
TH PADI6 0 0 67 263 1 1
TH INA 0 0 193 193 1 1
TH RTN4R 0 0 150 199 1 1
TH CGB2 0 0 0 190 1 1
TH CCNA2 0 0 95 153 1 1
TH SGSH 0 0 113 312 1 1
TH FAM19A4 0 0 107 185 1 1
TH GABRG1 0 0 330 344 1 1
TH ERBB4 0 0 211 250 1 1
TH CAV1 0 0 171 260 1 2
TH HSPA1A 0 0 115 171 1 1
TH AIF1 0 0 681 681 1 2
TH CHRNA7 0 0 142 245 1 1
TH PER2 0 0 264 264 1 1
TH KMO 0 0 95 360 1 1
TH SEMA7A 0 0 215 215 1 1
TH SCN9A 0 0 134 170 1 1
TH VCAM1 0 0 138 157 1 1
TH GNAL 0 0 138 197 1 1
TH MAP3K15 0 0 0 165 1 1
TH CD4 0 0 282 290 1 2
TH ATF4 0 0 270 276 1 2
TH PRKCG 0 0 229 245 1 1
TH CPE 0 0 125 282 1 1
TH UCN 0 0 283 290 1 1
TH FOXA1 0 0 181 221 1 1
TH PRDM16 0 0 225 242 1 1
TH GRIK1 0 0 194 221 1 1
TH LHX2 0 0 150 179 1 1
TH ST8SIA4 0 0 73 185 1 1
TH CSF2 0 0 155 154 1 1
TH PPARG 0 0 325 334 1 2
TH RBMXL1 197 0 0 197 1 1
TH RASD2 0 0 170 169 1 1
TH UBE3A 0 0 180 204 1 1
TH AKT1 0 0 502 536 1 2
TH SLC39A7 0 0 60 445 1 1
TH TGFB2 0 0 134 152 1 1
TH LHX3 0 0 210 225 1 1
TH PPP1R9B 0 0 230 229 1 1
TH TYSND1 270 0 0 270 1 1
TH SEMA6D 0 0 201 201 1 1
TH ASNS 0 0 0 173 1 1
TH PPP2R4 0 0 236 236 1 1
TH NOX4 0 0 168 167 1 2
TH SDHD 0 0 171 171 1 1
TH DISC1 0 0 422 429 1 1
TH KCNJ6 0 0 562 580 1 1
TH KLF4 0 0 294 294 1 2
TH RPL23L 0 0 309 497 1 1
TH ATF6 0 0 143 166 1 2
TH ACE2 0 0 136 177 1 2
TH NTRK2 0 0 561 588 1 1
TH GABRE 0 0 357 371 1 1
TH RPLP2 0 0 107 152 1 1
TH VIP 0 0 708 722 1 1
TH KIAA1033 0 0 245 254 1 1
TH FGFR1 273 0 202 407 1 1
TH EDNRB 0 0 150 191 1 1
TH RTN4 0 0 234 234 1 1
TH ANK3 0 0 270 297 1 1
TH HSP90AB1 0 0 0 216 1 2
TH FGF3 0 0 63 207 1 1
TH DRD4 0 0 528 530 1 1
TH CCK 0 0 612 636 1 1
TH GJA1 0 0 283 282 1 1
TH CHRD 0 0 49 213 1 1
TH GRM5 0 0 325 339 1 1
TH PINK1 0 0 607 758 1 2
TH FAAH 0 0 283 354 1 1
TH ATOH1 0 0 123 193 1 1
TH MAG 0 0 134 329 1 1
TH IL11 0 0 103 159 1 1
TH PHGDH 0 0 210 210 1 1
TH CLEC3B 0 0 70 280 1 1
TH PDE5A 0 0 124 151 1 1
TH BMP8B 0 0 134 152 1 1
TH OPRK1 0 0 249 248 1 1
TH NHLH2 0 0 150 185 1 1
TH SLC29A4 0 0 206 206 1 1
TH CHRM2 0 0 113 186 1 1
TH RHD 0 0 0 153 1 1
TH MRGPRD 0 0 288 288 1 1
TH PNOC 0 0 285 284 1 1
TH PRDX3 0 0 267 267 1 1
TH NGF 0 0 717 736 1 2
TH CD34 0 0 269 269 1 2
TH CREM 0 0 210 210 1 1
TH CLHC1 0 0 0 223 1 1
TH PITX3 0 0 710 717 1 1
TH PRKRA 0 0 232 231 1 1
TH SLIT3 0 0 167 182 1 1
TH INSC 0 0 232 273 1 1
TH CCNE2 0 0 0 159 1 1
TH SCGN 0 0 283 325 1 1
TH PDE4B 0 0 142 211 1 1
TH SP8 0 0 218 218 1 1
TH CRAT 0 0 0 159 1 1
TH DKK1 0 0 138 180 1 1
TH SRC 0 0 207 237 1 2
TH ADA 0 0 150 243 1 1
TH FEZF2 0 0 518 518 1 1
TH SLC2A4 0 0 150 192 1 1
TH DNAJC5 0 0 218 224 1 1
TH OXT 0 0 650 663 1 1
TH FOXO3 0 0 136 204 1 2
TH GATA5 0 0 45 165 1 1
TH APOE 0 0 324 323 1 2
TH CNPY1 0 0 201 236 1 1
TH YWHAB 213 0 306 456 1 1
TH TRPV2 0 0 170 182 1 1
TH BGLAP 0 0 150 170 1 1
TH LSR 0 0 60 472 1 1
TH DHFRL1 0 900 0 902 1 1
TH CRY1 0 0 213 267 1 1
TH CHRNA2 0 0 112 157 1 1
TH SYNGR3 0 0 166 212 1 1
TH HTR2A 0 0 458 472 1 1
TH GAD1 0 0 681 750 1 1
TH COMT 0 0 682 703 1 1
TH ADRA1B 0 0 264 366 1 1
TH POU4F1 0 0 390 406 1 1
TH EIF2AK3 0 0 261 261 1 2
TH SIM1 0 0 231 237 1 1
TH HRH1 0 0 210 210 1 1
TH SEMA4F 0 0 218 218 1 1
TH TLR3 0 0 113 204 1 2
TH NEUROD2 0 0 122 164 1 1
TH IL4I1 0 900 60 901 1 1
TH KDR 0 0 170 169 1 2
TH MITF 0 0 140 171 1 2
TH NTN1 0 0 209 226 1 1
TH TOMM20 0 0 315 327 1 2
TH SEMA3F 0 0 241 240 1 1
TH P2RX1 0 0 167 167 1 1
TH AGTR2 0 0 136 207 1 1
TH TRIT1 0 0 81 174 1 1
TH HTR1D 0 0 203 203 1 1
TH DCX 0 0 557 583 1 1
TH LIN28B 0 0 88 159 1 1
TH NRG1 0 0 272 284 1 2
TH PNP 0 0 307 322 1 1
TH SLC18A1 0 0 459 738 1 1
TH TUBB2A 0 0 125 203 1 1
TH LRRK1 0 0 96 354 1 1
TH HMOX1 0 0 456 480 1 2
TH SLC6A2 0 0 748 814 1 1
TH SLC17A7 0 0 617 678 1 1
TH NEUROD4 0 0 124 162 1 1
TH CACNA1A 0 0 181 259 1 1
TH TLX3 0 0 171 195 1 1
TH PRKCD 0 0 282 282 1 2
TH CYP2D6 0 0 155 164 1 1
TH ASIC3 0 0 171 171 1 1
TH CDKN1B 0 0 81 224 1 2
TH CTCF 0 0 95 237 1 1
TH IRX6 0 0 103 202 1 1
TH DIO2 0 0 260 276 1 1
TH GRM6 0 0 161 195 1 1
TH HRH4 0 0 97 235 1 1
TH VDAC1 0 0 217 217 1 2
TH TGFB1 0 0 137 190 1 2
TH MC4R 0 0 371 396 1 1
TH HCRTR2 0 0 176 195 1 1
TH OTP 0 0 373 519 1 1
TH GLUL 0 0 391 429 1 1
TH ADORA2B 0 0 275 284 1 1
TH SEMA5B 0 0 211 211 1 1
TH NR1D1 0 0 244 243 1 2
TH FOXA2 0 0 521 544 1 1
TH FGF16 0 0 0 189 1 1
TH HPCA 0 0 156 171 1 1
TH HPRT1 0 0 324 326 1 1
TH DLGAP3 0 0 112 150 1 1
TH GBA 0 0 295 369 1 1
TH PHOX2B 0 0 681 720 1 1
TH FAH 0 0 70 377 1 1
TH SV2B 0 0 171 195 1 1
TH TBC1D17 0 0 0 207 1 1
TH SEMA4G 0 0 193 193 1 1
TH KCND1 0 0 74 152 1 1
TH LIN28A 0 0 193 207 1 1
TH TRPS1 0 0 0 161 1 1
TH GALR1 0 0 294 309 1 1
TH CHIT1 0 0 0 207 1 1
TH IDE 0 0 141 164 1 1
TH CAT 0 0 421 459 1 2
TH PECAM1 0 0 282 282 1 1
TH PCSK2 0 0 161 329 1 1
TH GIP 0 0 155 154 1 1
TH HPD 0 0 46 343 1 1
TH POU5F1 0 0 370 392 1 2
TH ENSG00000264813 0 0 310 343 1 1
TH NPR2 0 0 160 176 1 1
TH GRIK5 0 0 143 153 1 1
TH GCH1 0 0 727 875 1 1
TH HGF 0 0 173 174 1 2
TH TXN 0 0 172 184 1 1
TH GRIA1 0 0 508 551 1 1
TH SLC39A8 0 0 118 198 1 1
TH NUBP2 0 0 143 166 1 1
TH HTR3B 0 0 193 210 1 1
TH CCNE1 0 0 0 159 1 1
TH CAST 0 0 172 171 1 2
TH OPRM1 0 0 523 523 1 1
TH HAPLN1 0 0 155 160 1 1
TH DRD1 0 0 653 777 1 1
TH LOX 0 0 373 373 1 2
TH EGR2 0 0 193 193 1 1
TH NPFF 0 0 210 231 1 1
TH SAG 0 0 210 210 1 1
TH SCN11A 0 0 176 192 1 1
TH LHB 0 0 505 539 1 1
TH IRS1 0 0 134 152 1 2
TH SYN3 0 0 167 310 1 1
TH HSPA9 0 0 142 158 1 1
TH ADRA1D 0 0 161 277 1 1
TH EPOR 0 0 152 204 1 1
TH GLRA1 0 0 142 192 1 1
TH SCAI 0 0 66 166 1 1
TH PROK2 0 0 146 180 1 1
TH ASIC1 0 0 120 153 1 2
TH EDNRA 0 0 172 185 1 1
TH NTRK1 0 0 510 528 1 1
TH RIC8B 0 0 503 503 1 1
TH PGR 0 0 203 217 1 1
TH GADL1 0 0 67 271 1 1
TH OLIG2 0 0 401 419 1 1
TH YWHAQ 270 0 324 496 1 1
TH ADRB2 0 0 459 459 1 1
TH GRP 0 0 408 420 1 2
TH AGTR1 0 0 310 309 1 1
TH RPS6KB1 0 0 172 171 1 2
TH SEMA3A 0 0 294 294 1 1
TH ZNF569 238 0 0 237 1 1
TH KCNK9 0 0 142 186 1 1
TH JUND 0 0 170 169 1 1
TH NOS3 0 0 323 328 1 2
TH NR5A1 0 0 234 250 1 1
TH ALDOC 0 0 83 160 1 1
TH GPR139 0 0 62 318 1 1
TH CCND1 0 0 170 176 1 2
TH AGXT 0 0 43 208 1 1
TH INS-IGF2 0 0 160 217 1 1
TH CACNA1B 0 0 253 285 1 1
TH GPR143 0 0 134 157 1 1
TH ALDH2 0 0 166 208 1 2
TH FGF5 0 0 48 194 1 1
TH ADRA2C 0 0 235 266 1 1
TH NCF1 0 0 194 194 1 1
TH TRH 0 0 502 515 1 1
TH SLC17A8 0 0 595 659 1 1
TH SV2C 0 0 261 277 1 1
TH SNCG 0 0 309 364 1 1
TH CSNK2A1 213 0 71 237 1 1
TH BCL2A1 0 0 180 197 1 1
TH SHROOM2 0 0 0 256 1 1
TH PCBD1 0 900 414 953 1 1
TH SLC17A9 0 0 244 257 1 1
TH FGF2 0 0 595 602 1 2
TH REST 0 0 222 222 1 2
TH RPH3A 0 0 154 180 1 1
TH ATP12A 0 0 150 180 1 1
TH GCG 0 0 458 457 1 1
TH TNNT2 0 0 48 213 1 1
TH IREB2 0 0 171 172 1 1
TH GOT1L1 0 900 0 914 1 1
TH TFAP2A 0 0 127 187 1 1
TH TFRC 0 0 294 319 1 1
TH VWF 0 0 167 180 1 1
TH PRDX2 0 0 163 163 1 1
TH AGT 0 0 183 323 1 1
TH ARNTL 0 0 324 373 1 1
TH GRIA3 0 0 142 218 1 1
TH MAPK1 463 0 193 577 1 2
TH ASMT 0 0 162 174 1 1
TH IGF1 0 0 392 420 1 2
TH ITIH4 0 0 167 186 1 1
TH ATF3 0 0 194 195 1 2
TH NAPEPLD 0 0 167 266 1 1
TH RPS10 0 0 0 347 1 1
TH CNR1 0 0 621 630 1 1
TH MMP3 0 0 123 165 1 1
TH HDC 0 0 339 647 1 1
TH KCND2 0 0 113 168 1 1
TH SIX3 0 0 182 181 1 1
TH NR4A2 0 0 766 814 1 1
TH HTR2C 0 0 325 354 1 1
TH CHIA 0 0 0 207 1 1
TH DAAM2 251 0 0 267 1 1
TH VDR 0 0 170 179 1 2
TH CD44 0 0 218 218 1 2
TH MEF2C 0 0 126 167 1 1
TH BDNF 0 0 739 778 1 2
TH DCT 0 0 166 165 1 1
TH CGB1 0 0 0 190 1 1
TH MC3R 0 0 234 250 1 1
TH NT5E 0 0 160 159 1 1
TH SRR 0 0 98 154 1 1
TH KYNU 0 0 54 306 1 1
TH PAFAH1B1 0 0 112 181 1 1
TH SEMA4D 0 0 186 186 1 1
TH TUBB4B 0 0 67 150 1 1
TH GYPE 0 0 505 505 1 1
TH GABRG2 0 0 81 177 1 1
TH EYA1 0 0 48 185 1 1
TH PLCB1 0 0 95 151 1 1
TH TNF 0 0 457 490 1 2
TH OXTR 0 0 282 282 1 1
TH SNAP25 0 0 426 459 1 1
TH LCMT2 0 0 234 310 1 1
TH MSX1 0 0 285 297 1 1
TH PAX3 0 0 189 203 1 1
TH PAH 0 800 683 835 1 1
TH FMR1 0 0 184 183 1 1
TH GRM4 0 0 181 199 1 1
TH RBFOX3 0 0 704 712 1 1
TH TPBG 0 0 167 182 1 1
TH SLC25A29 0 0 0 166 1 1
TH CNGA2 0 0 255 321 1 1
TH BTF3 0 0 253 252 1 1
TH SYN2 0 0 216 350 1 1
TH DAGLA 0 0 161 161 1 1
TH ANKK1 0 0 210 221 1 1
TH ALDH7A1 0 0 249 265 1 1
TH ATP13A2 0 0 414 414 1 1
TH TAC3 0 0 310 309 1 1
TH HCRTR1 0 0 408 420 1 1
TH GPR55 0 0 181 186 1 1
TH FIS1 0 0 141 194 1 2
TH MAP3K5 0 0 150 260 1 1
TH DIO3 0 0 75 150 1 1
TH BACE1 0 0 283 302 1 2
TH TUBB 0 0 87 168 1 1
TH GATA2 0 0 241 461 1 1
TH HOMER1 0 0 234 234 1 1
TH TRPA1 0 0 236 385 1 1
TH ITGAM 0 0 391 413 1 1
TH NSD1 0 0 280 280 1 1
TH EN1 0 0 560 605 1 1
TH RCVRN 0 0 166 181 1 1
TH ESR1 0 0 451 457 1 2
TH PDE10A 0 0 138 214 1 1
TH HMGB1 0 0 161 162 1 2
TH ADCY8 0 0 113 157 1 1
TH SPI1 0 0 58 177 1 1
TH NOX1 0 0 151 150 1 1
TH PRL 0 0 566 566 1 1
TH PCBP3 0 0 157 171 1 1
TH SIRT1 0 0 302 320 1 2
TH AIRE 0 0 122 252 1 1
TH DLK1 0 0 162 181 1 1
TH EOMES 0 0 171 176 1 1
TH OTX2 0 0 467 500 1 1
TH GRM2 0 0 320 334 1 1
TH SEMA6C 0 0 208 208 1 1
TH F9 0 0 72 170 1 1
TH MANF 0 0 391 485 1 1
TH SLC6A3 0 0 880 911 1 1
TH ATOH7 0 0 86 152 1 1
TH GATA6 0 0 44 164 1 1
TH ATP4A 0 0 150 180 1 1
TH CNTNAP2 0 0 129 166 1 1
TH ATG5 0 0 160 159 1 2
TH CAMK2G 213 0 0 300 1 1
TH SPX 0 0 88 188 1 1
TH CHRNB2 0 0 120 169 1 1
TH MT-ND1 0 0 104 165 1 1
TH WNT3A 0 0 144 160 1 2
TH GRIN1 0 0 465 518 1 1
TH SYP 0 0 662 676 1 1
TH CAMK1 0 0 141 227 1 1
TH CRH 0 0 681 696 1 1
TH LGR5 0 0 87 157 1 1
TH UBC 0 0 251 250 1 2
TH MCAM 0 0 86 249 1 1
TH MAP1LC3B 0 0 181 186 1 2
TH PIGA 0 0 0 150 1 1
TH HAND2 0 0 364 378 1 1
TH HMOX2 0 0 218 262 1 1
TH NRTN 0 0 611 668 1 1
TH PCDH11X 0 0 91 170 1 1
TH GALR3 0 0 243 254 1 1
TH NKX2-1 0 0 327 421 1 1
TH GALC 0 0 249 285 1 1
TH MGLL 0 0 216 216 1 1
TH TYRP1 0 0 212 212 1 1
TH ADRB1 0 0 391 404 1 1
TH HSPB1 0 0 183 191 1 2
TH GLI1 0 0 161 161 1 2
TH PRLHR 0 0 108 160 1 1
TH HSPB2 0 0 150 158 1 1
TH RAB3A 0 0 184 218 1 1
TH CASR 0 0 294 309 1 2
TH MT-CO1 0 0 124 163 1 1
TH TBP 0 0 166 215 1 1
TH FN1 0 0 323 323 1 2
TH PCBP1 0 0 160 159 1 1
TH SSTR1 0 0 122 159 1 1
TH LRRC20 0 0 0 245 1 1
TH GAL 0 0 748 754 1 1
TH RNLS 0 0 181 197 1 1
TH GPX1 0 0 171 187 1 1
TH PTH2 0 0 204 213 1 1
TH NPS 0 0 194 194 1 1
TH RCOR1 0 0 161 182 1 1
TH RPS18 0 0 96 342 1 1
TH GALP 0 0 162 161 1 1
TH PIGQ 0 0 309 309 1 1
TH PRKCA 0 0 299 314 1 1
TH TBX21 0 0 62 162 1 1
TH TENM3 0 0 49 191 1 1
TH GUCY2C 0 0 63 159 1 1
TH HNRNPK 114 0 108 175 1 1
TH CYP11B2 0 0 150 180 1 1
TH DLX1 0 0 263 310 1 1
TH NCAM1 0 0 390 425 1 1
TH CAMK2A 0 0 181 234 1 2
TH NRXN1 0 0 181 181 1 1
TH RET 0 0 390 450 1 1
TH SOX10 0 0 391 418 1 1
TH ENSG00000214026 0 0 309 497 1 1
TH KLK6 0 0 293 310 1 1
TH SEMA3E 0 0 209 209 1 1
TH AGRP 0 0 587 595 1 1
TH SGCE 0 0 339 339 1 1
TH ENG 0 0 162 161 1 2
TH GOT2 0 900 90 918 1 1
TH CA4 0 0 151 161 1 1
TH FGF12 0 0 0 190 1 1
TH IGF2 0 0 341 357 1 1
TH CTSD 0 0 175 192 1 2
TH GABRA2 0 0 309 324 1 1
TH KCNA2 0 0 128 164 1 1
TH DRD5 0 0 457 651 1 1
TH NTF4 0 0 456 461 1 1
TH GAD2 0 0 607 686 1 1
TH TRIM32 0 0 204 213 1 1
TH SEMA6B 0 0 195 195 1 1
TH PFN2 0 0 54 271 1 1
TH GFRA1 0 0 455 466 1 1
TH GFAP 0 0 681 719 1 2
TH DBH 0 0 877 945 1 1
TH IL10 0 0 323 355 1 2
TH TJP1 0 0 156 155 1 1
TH TAC1 0 0 804 808 1 1
TH HTR2B 0 0 193 193 1 1
TH SYT2 0 0 234 285 1 1
TH ATG7 0 0 213 242 1 2
TH FOSB 0 0 418 466 1 1
TH DLG4 0 0 469 490 1 2
TH IKZF1 0 0 56 157 1 1
TH FOSL2 0 0 202 216 1 1
TH ACTG1 0 0 219 267 1 1
TH OPRD1 0 0 139 181 1 1
TH DNM1L 0 0 170 221 1 2
TH QDPR 0 900 464 951 1 1
TH NTRK3 0 0 393 410 1 1
TH GPR52 0 0 67 274 1 1
TH DRD3 0 0 505 569 1 1
TH PCBD2 0 900 0 924 1 1
TH CD200 0 0 170 169 1 1
TH SLC39A14 0 0 75 159 1 1
TH GC 0 0 49 159 1 1
TH CHL1 0 0 466 486 1 1
TH FEZ1 0 0 123 160 1 1
TH VEGFA 0 0 392 392 1 2
TH SLC2A14 0 0 161 202 1 1
TH MAPK7 0 0 128 160 1 1
TH RPL10A 0 0 176 175 1 1
TH PTEN 0 0 383 394 1 2
TH FTL 0 0 327 327 1 1
TH MBP 0 0 464 467 1 2
TH ARTN 0 0 335 344 1 1
TH POU4F3 0 0 93 179 1 1
TH ENSG00000258947 0 0 459 620 1 1
TH MAPK14 0 900 150 918 1 2
TH NGFR 0 0 390 403 1 1
TH BAG1 0 0 63 165 1 2
TH NPY1R 0 0 294 294 1 1
TH GCHFR 0 0 172 315 1 1
TH MAPK10 0 0 153 181 1 2
TH PCP4 0 0 123 165 1 1
TH UCP1 0 0 510 510 1 2
TH BMP4 0 0 280 295 1 1
TH CCKBR 0 0 166 166 1 1
TH GABRQ 0 0 435 447 1 1
TH NPTX2 0 0 140 184 1 1
TH MC2R 0 0 236 251 1 1
TH AIMP2 0 0 164 255 1 1
TH LEP 0 0 502 520 1 1
TH KIT 0 0 181 181 1 2
TH NFKBIA 0 0 193 206 1 2
TH HFE 0 0 107 168 1 1
TH ACE 0 0 320 352 1 1
TH FGF22 0 0 0 185 1 1
TH GPR6 0 0 134 171 1 1
TH REN 0 0 393 414 1 1
TH SLC1A1 0 0 310 328 1 1
TH GSX1 0 0 193 209 1 1
TH GPER1 0 0 183 183 1 2
TH VPS13A 0 0 187 187 1 1
TH IL13 0 0 179 179 1 2
TH CYBB 0 0 310 315 1 2
TH INSM1 0 0 125 163 1 1
TH PTS 0 0 304 425 1 1
TH GRM1 0 0 260 276 1 1
TH PPIA 0 0 218 218 1 1
TH TRPC4 0 0 171 171 1 1
TH OMP 0 0 506 506 1 1
TH CHRNB3 0 0 134 179 1 1
TH HAAO 0 0 0 339 1 1
TH HCRT 0 0 634 650 1 1
TH P2RX3 0 0 366 380 1 1
TH NLRP3 0 0 193 193 1 2
TH REL 0 0 140 181 1 2
TH PLA2G6 0 0 219 219 1 1
TH GNA15 0 0 148 163 1 1
TH GABRB3 0 0 143 209 1 1
TH CCKAR 0 0 181 181 1 1
TH SSTR2 0 0 123 164 1 1
TH AFP 0 0 193 270 1 2
TH ZBTB34 179 0 0 179 1 1
TH TUB 0 0 181 411 1 1
TH RGN 0 0 71 171 1 1
TH SLC23A2 0 0 141 188 1 1
TH EEF1A1 0 0 247 257 1 1
TH PTGS2 0 0 400 419 1 2
TH FGF19 0 0 0 189 1 1
TH RPS10-NUDT3 0 0 0 347 1 1
TH CASP3 0 0 563 576 1 2
TH NQO1 0 0 212 212 1 2
TH TG 0 0 148 179 1 1
TH AK1 0 0 263 263 1 1
TH TSPO 0 0 234 234 1 1
TH FGF9 0 0 54 199 1 1
TH DHFR 0 900 184 917 1 1
TH SOX1 0 0 394 417 1 1
TH ZNF24 0 0 258 258 1 1
TH C3orf17 0 0 166 165 1 1
TH FGF11 0 0 0 189 1 1
TH YWHAH 0 0 353 363 1 1
TH GPI 0 0 323 323 1 2
TH PHC3 0 0 181 181 1 1
TH HDAC1 0 0 164 185 1 2
TH ACO1 0 0 150 174 1 1
TH CGB5 0 0 0 190 1 1
TH PDCD11 0 0 0 191 1 1
TH EGFLAM 0 0 0 157 1 1
TH ARRB2 0 0 213 222 1 1
TH SST 0 0 681 700 1 1
TH GK 0 0 0 152 1 1
TH CGB8 0 0 82 224 1 1
TH ADM 0 0 181 181 1 2
TH SFN 0 0 134 170 1 2
TH GUSB 0 0 170 169 1 1
TH FGF8 0 0 561 580 1 1
TH GPX8 0 0 0 258 1 1
TH LHX6 0 0 234 260 1 1
TH ARRB1 0 0 105 169 1 1
TH GSK3B 0 0 268 341 1 2
TH MRC1 0 0 181 190 1 1
TH GRIN3A 0 0 108 287 1 1
TH PNISR 0 0 0 300 1 1
TH S100B 0 0 504 514 1 1
TH NTF3 0 0 518 533 1 1
TH WNT2 0 0 118 244 1 1
TH CACNA1H 0 0 164 194 1 1
TH MCHR2 0 0 120 180 1 1
TH CGB7 0 0 91 232 1 1
TH DNM1 0 0 127 233 1 1
TH AKR1A1 0 0 155 210 1 1
TH PDYN 0 0 681 688 1 1
TH VIPR1 0 0 234 251 1 1
TH CHRNB4 0 0 155 173 1 1
TH AVPR1A 0 0 216 246 1 1
TH HSPA5 0 0 235 280 1 2
TH FOXP2 0 0 292 322 1 1
TH FGF20 0 0 308 314 1 1
TH PNKD 0 0 269 269 1 1
TH CAMK4 0 0 141 159 1 1
TH ASCL1 0 0 517 528 1 1
TH TBC1D25 0 0 46 211 1 1
TH FTH1 0 0 150 173 1 1
TH EPAS1 0 0 154 168 1 2
TH PGD 0 0 86 244 1 1
TH FOXO1 0 0 173 191 1 2
TH GFRA3 0 0 76 159 1 1
TH ADRBK1 0 0 166 172 1 1
TH DTNBP1 0 0 173 173 1 1
TH CHRNA5 0 0 142 190 1 1
TH PTH 0 0 323 323 1 1
TH CBLN1 0 0 150 225 1 1
TH SOD2 0 0 254 274 1 2
TH GNB3 0 0 193 193 1 1
TH FOS 0 0 736 803 1 2
TH SV2A 0 0 414 441 1 1
TH GHSR 0 0 270 303 1 1
TH THRB 0 0 60 167 1 1
TH SNCB 0 0 452 513 1 1
TH YWHAZ 698 0 617 883 1 1
TH LSAMP 0 0 134 193 1 1
TH CA1 0 0 142 172 1 1
TH SOCS3 0 0 144 163 1 1
TH PHF1 0 0 144 315 1 1
TH PPAT 0 0 0 161 1 1
TH LMO1 0 0 86 156 1 1
TH AQP4 0 0 211 239 1 1
TH PPP1R1A 0 0 0 155 1 1
TH ADCYAP1R1 0 0 236 253 1 1
TH GABBR1 0 0 324 338 1 1
TH TACR1 0 0 394 407 1 1
TH MCHR1 0 0 354 370 1 1
TH CNP 0 0 245 277 1 1
TH SLC40A1 0 0 265 265 1 1
TH SCN8A 0 0 163 197 1 1
TH SEMA5A 0 0 217 217 1 1
TH CHRM4 0 0 128 165 1 1
TH ADCY3 0 0 134 170 1 1
TH DLX5 0 0 183 197 1 1
TH SIGMAR1 0 0 150 168 1 1
TH SAAL1 0 0 53 153 1 1
TH PTF1A 0 0 156 243 1 1
TH MAPT 0 0 459 474 1 2
TH BECN1 0 0 260 260 1 2
TH MAOB 0 0 687 695 1 1
TH NAP1L4 0 0 329 329 1 1
TH TBC1D21 0 0 0 207 1 1
TH ALDH1A1 0 0 294 329 1 1
TH STXBP1 0 0 134 167 1 1
TH TLR6 0 0 0 157 1 1
TH GYS1 0 0 0 164 1 1
TH IL2 0 0 195 195 1 1
TH ADCY10 0 0 134 153 1 1
TH TLR2 0 0 203 216 1 2
TH NTSR2 0 0 229 245 1 1
TH MAPK11 0 900 57 906 1 1
TH LRRK2 0 0 654 752 1 2
TH ATXN3 0 0 180 179 1 2
TH ELAVL4 0 0 325 385 1 1
TH GNAO1 0 0 182 211 1 1
TH GRIN2B 0 0 426 459 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0016597 Molecular Function amino acid binding enables IEA
GO:0035240 Molecular Function dopamine binding enables IEA
GO:0019899 Molecular Function enzyme binding enables IPI
GO:0008199 Molecular Function ferric iron binding enables IEA
GO:0008198 Molecular Function ferrous iron binding enables IEA
GO:0019825 Molecular Function oxygen binding enables IEA
GO:0005515 Molecular Function protein binding enables IPI
GO:0019904 Molecular Function protein domain specific binding enables IEA
GO:0034617 Molecular Function tetrahydrobiopterin binding enables IEA
GO:0004511 Molecular Function tyrosine 3-monooxygenase activity enables IBA
GO:0004511 Molecular Function tyrosine 3-monooxygenase activity enables IDA
GO:0015842 Biological Process aminergic neurotransmitter loading into synaptic vesicle involved_in IEA
GO:0009653 Biological Process anatomical structure morphogenesis involved_in TAS
GO:0009887 Biological Process animal organ morphogenesis involved_in ISS
GO:0071312 Biological Process cellular response to alkaloid involved_in IEA
GO:0071333 Biological Process cellular response to glucose stimulus involved_in IEA
GO:0071363 Biological Process cellular response to growth factor stimulus involved_in IEA
GO:0071287 Biological Process cellular response to manganese ion involved_in IEA
GO:0071316 Biological Process cellular response to nicotine involved_in IEA
GO:0071466 Biological Process cellular response to xenobiotic stimulus involved_in IEA
GO:0021987 Biological Process cerebral cortex development involved_in IEA
GO:0042745 Biological Process circadian sleep/wake cycle involved_in IEA
GO:0042416 Biological Process dopamine biosynthetic process involved_in IDA
GO:0006585 Biological Process dopamine biosynthetic process from tyrosine involved_in IBA
GO:0006585 Biological Process dopamine biosynthetic process from tyrosine involved_in NAS
GO:0042755 Biological Process eating behavior involved_in IEA
GO:0048596 Biological Process embryonic camera-type eye morphogenesis involved_in ISS
GO:0042418 Biological Process epinephrine biosynthetic process involved_in IDA
GO:0042462 Biological Process eye photoreceptor cell development involved_in ISS
GO:0006631 Biological Process fatty acid metabolic process involved_in IEA
GO:0016137 Biological Process glycoside metabolic process involved_in IEA
GO:0007507 Biological Process heart development involved_in IBA
GO:0007507 Biological Process heart development involved_in ISS
GO:0003007 Biological Process heart morphogenesis involved_in NAS
GO:1990384 Biological Process hyaloid vascular plexus regression involved_in ISS
GO:0033076 Biological Process isoquinoline alkaloid metabolic process involved_in IEA
GO:0007612 Biological Process learning involved_in ISS
GO:0007626 Biological Process locomotory behavior involved_in ISS
GO:0007617 Biological Process mating behavior involved_in IEA
GO:0007613 Biological Process memory involved_in ISS
GO:0042421 Biological Process norepinephrine biosynthetic process involved_in IDA
GO:0018963 Biological Process phthalate metabolic process involved_in IEA
GO:0052314 Biological Process phytoalexin metabolic process involved_in IEA
GO:0043473 Biological Process pigmentation involved_in TAS
GO:0008016 Biological Process regulation of heart contraction involved_in ISS
GO:0014823 Biological Process response to activity involved_in IEA
GO:0001975 Biological Process response to amphetamine involved_in IEA
GO:0051412 Biological Process response to corticosterone involved_in IEA
GO:0051602 Biological Process response to electrical stimulus involved_in IEA
GO:0032355 Biological Process response to estradiol involved_in IEA
GO:0045471 Biological Process response to ethanol involved_in IBA
GO:0045471 Biological Process response to ethanol involved_in IDA
GO:0045472 Biological Process response to ether involved_in IEA
GO:0009635 Biological Process response to herbicide involved_in IEA
GO:0001666 Biological Process response to hypoxia involved_in IBA
GO:0001666 Biological Process response to hypoxia involved_in IDA
GO:0035902 Biological Process response to immobilization stress involved_in IEA
GO:0035900 Biological Process response to isolation stress involved_in IEA
GO:0009416 Biological Process response to light stimulus involved_in IEA
GO:0032496 Biological Process response to lipopolysaccharide involved_in IEA
GO:0031667 Biological Process response to nutrient levels involved_in IEA
GO:0043434 Biological Process response to peptide hormone involved_in IEA
GO:0046684 Biological Process response to pyrethroid involved_in IEA
GO:0009651 Biological Process response to salt stress involved_in IEA
GO:0010043 Biological Process response to zinc ion involved_in IEA
GO:0035176 Biological Process social behavior involved_in IEA
GO:0006665 Biological Process sphingolipid metabolic process involved_in IEA
GO:0001963 Biological Process synaptic transmission, dopaminergic involved_in ISS
GO:0042214 Biological Process terpene metabolic process involved_in IEA
GO:0007601 Biological Process visual perception involved_in ISS
GO:0030424 Cellular Component axon is_active_in IBA
GO:0005737 Cellular Component cytoplasm is_active_in IBA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0009898 Cellular Component cytoplasmic side of plasma membrane located_in IDA
GO:0031410 Cellular Component cytoplasmic vesicle located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0030425 Cellular Component dendrite located_in IEA
GO:0033162 Cellular Component melanosome membrane located_in IDA
GO:0005739 Cellular Component mitochondrion located_in IEA
GO:0043005 Cellular Component neuron projection located_in IDA
GO:0005634 Cellular Component nucleus located_in IDA
GO:0005634 Cellular Component nucleus located_in ISS
GO:0043204 Cellular Component perikaryon is_active_in IBA
GO:0043204 Cellular Component perikaryon located_in ISS
GO:0048471 Cellular Component perinuclear region of cytoplasm located_in ISS
GO:0005790 Cellular Component smooth endoplasmic reticulum located_in IDA
GO:0008021 Cellular Component synaptic vesicle located_in IEA
GO:0043195 Cellular Component terminal bouton located_in IEA
Pathways
Name DB ID
Metabolism Reactome R-HSA-1430728
Metabolism of amine-derived hormones Reactome R-HSA-209776
Catecholamine biosynthesis Reactome R-HSA-209905
Metabolism of amino acids and derivatives Reactome R-HSA-71291
Dopamine metabolism (WP2436) WikiPathways WP2436_r107129
Parkinson's disease pathway (WP2371) WikiPathways WP2371_r119919
Sudden infant death syndrome (SIDS) susceptibility pathways (WP706) WikiPathways WP706_r117178
Sleep regulation (WP3591) WikiPathways WP3591_r88424
Circadian rhythm genes (WP3594) WikiPathways WP3594_r117682
Dopaminergic neurogenesis (WP2855) WikiPathways WP2855_r117704
Nicotine effect on dopaminergic neurons (WP1602) WikiPathways WP1602_r117165
Neurotransmitter disorders (WP4220) WikiPathways WP4220_r123757
Monoamine transport (WP727) WikiPathways WP727_r116775
Amino acid metabolism (WP3925) WikiPathways WP3925_r123124
Biogenic amine synthesis (WP550) WikiPathways WP550_r119093
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_000360 4 mRNA transcript variant 2 NC_000011 Reference
NM_199293 3 mRNA transcript variant 3 NC_000011 Reference
XM_011520335 3 mRNA transcript variant X1 NC_000011 Reference
NM_199292 3 mRNA transcript variant 1 NC_000011 Reference