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TRAF3

TNF receptor associated factor 3
General Information
Name TNF receptor associated factor 3
Alias
  • TNF receptor-associated factor 3
  • CD40 associated protein 1
  • CD40 binding protein
  • CD40 receptor associated factor 1
  • LMP1-associated protein 1
  • RING-type E3 ubiquitin transferase TRAF3
Gene_family Zinc fingers TRAF-type|Ring finger proteins|TNF receptor associated factors
organism Homo sapiens
entrez_id 7187
location 14q32.32
transcript_count 18
exon_count 16
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]
    Stringdb TNF receptor-associated factor 3; Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of [...]
    nextProt Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:25847972, PubMed:27980081). Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance (PubMed:27438768). Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
TRAF3 BioGRID TRAF2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; FRET; Negative Genetic
TRAF3 BioGRID HNRNPU GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID CARD19 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TNFRSF1B GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TRAF3 BioGRID MAVS GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TRAF3 BioGRID TBK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
TRAF3 BioGRID MAP3K14 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAF3 BioGRID RIPK2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAF3 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID TFG GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TRAF3 BioGRID ULK1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TIFA GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID RNF126 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID DYRK1A GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TRAF3 BioGRID CKMT1A GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID HDHD3 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID MFF GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
TRAF3 BioGRID SLC25A40 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID PGM2 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID RETSAT GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID PSAT1 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID PYCARD GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID PISD GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID CAP1 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID SLC4A7 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID GSTO1 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID CDS2 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID UGP2 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID PRKG2 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID PIK3R2 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID PDE9A GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID ME1 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID PRMT1 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID GUCY1B1 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID GSTP1 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID GPI GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID EWSR1 GeneID BioGRID Affinity Capture-MS; Two-hybrid
TRAF3 BioGRID DBI GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID CSNK2A2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TRAF3 BioGRID CDC42 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID APEH GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID ALDH3A1 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID ACAT2 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID MAP1LC3B GeneID BioGRID Proximity Label-MS
TRAF3 BioGRID ETV6 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
TRAF3 BioGRID ATP1B1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID CALCOCO2 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
TRAF3 BioGRID TAX1BP1 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
TRAF3 BioGRID SQSTM1 GeneID BioGRID Proximity Label-MS
TRAF3 BioGRID M GeneID BioGRID Affinity Capture-Western; Co-localization
TRAF3 BioGRID M GeneID BioGRID Affinity Capture-Western; Co-localization
TRAF3 BioGRID TANK GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Protein-peptide; Reconstituted Complex; Two-hybrid
TRAF3 BioGRID IKBKE GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TNFRSF14 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TRAF3 BioGRID LTBR GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; Phenotypic Suppression; Reconstituted Complex
TRAF3 BioGRID NCKAP5 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID NUDCD2 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID HECTD3 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID EDA2R GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TRAF3 BioGRID TSKS GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID PCDH10 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID MFN1 GeneID BioGRID Affinity Capture-Western; Co-fractionation; Co-localization
TRAF3 BioGRID SHPK GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID NUP62 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
TRAF3 BioGRID NEDD4L GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TRAF3 BioGRID SNAP29 GeneID BioGRID Affinity Capture-MS; Two-hybrid
TRAF3 BioGRID KRT38 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID TLR4 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-localization
TRAF3 BioGRID FOXO1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID ECH1 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID DAZL GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID TNFRSF8 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
TRAF3 BioGRID BIRC3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
TRAF3 BioGRID BIRC2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TRAF3 BioGRID SHANK3 GeneID BioGRID Two-hybrid
TRAF3 BioGRID DDX39A GeneID BioGRID Affinity Capture-RNA
TRAF3 BioGRID GMEB1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
TRAF3 BioGRID OTUD7B GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID PTPN6 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TRAF3 BioGRID MAP3K5 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID CSNK1E GeneID BioGRID Affinity Capture-Western; Biochemical Activity
TRAF3 BioGRID BLK GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID CD40 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Protein-peptide; Reconstituted Complex; Two-hybrid
TRAF3 BioGRID TRIM24 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
TRAF3 BioGRID TRAF3IP3 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID CRTC1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID EGFR GeneID BioGRID Positive Genetic
TRAF3 BioGRID RNF144B GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID USP7 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TRAF3 BioGRID OTUB1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID MSR1 GeneID BioGRID Affinity Capture-Western; Co-localization
TRAF3 BioGRID TICAM1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID LGALS3BP GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID PDZD4 GeneID BioGRID Two-hybrid
TRAF3 BioGRID HEMGN GeneID BioGRID Two-hybrid
TRAF3 BioGRID NTAQ1 GeneID BioGRID Two-hybrid
TRAF3 BioGRID BIVM GeneID BioGRID Two-hybrid
TRAF3 BioGRID IFT25 GeneID BioGRID Two-hybrid
TRAF3 BioGRID ASCC1 GeneID BioGRID Two-hybrid
TRAF3 BioGRID GMEB2 GeneID BioGRID Two-hybrid
TRAF3 BioGRID CDC37 GeneID BioGRID Two-hybrid
TRAF3 BioGRID POM121 GeneID BioGRID Two-hybrid
TRAF3 BioGRID PIAS2 GeneID BioGRID Two-hybrid
TRAF3 BioGRID ORF1ab GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID ORF3a GeneID BioGRID Affinity Capture-Western; Co-localization
TRAF3 BioGRID C10orf62 GeneID BioGRID Two-hybrid
TRAF3 BioGRID CCDC184 GeneID BioGRID Two-hybrid
TRAF3 BioGRID ZSCAN4 GeneID BioGRID Two-hybrid
TRAF3 BioGRID ZBTB49 GeneID BioGRID Two-hybrid
TRAF3 BioGRID CCDC13 GeneID BioGRID Two-hybrid
TRAF3 BioGRID IP6K3 GeneID BioGRID Two-hybrid
TRAF3 BioGRID RIPPLY1 GeneID BioGRID Two-hybrid
TRAF3 BioGRID LNX1 GeneID BioGRID Two-hybrid
TRAF3 BioGRID RIPK1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
TRAF3 BioGRID UBE2I GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAF3 BioGRID TRAF5 GeneID BioGRID Affinity Capture-MS; Co-localization; FRET; Two-hybrid
TRAF3 BioGRID TRAF3 GeneID BioGRID Affinity Capture-Western; Co-crystal Structure; FRET; Two-hybrid
TRAF3 BioGRID RNF4 GeneID BioGRID Two-hybrid
TRAF3 BioGRID RAD23A GeneID BioGRID Two-hybrid
TRAF3 BioGRID PSMB8 GeneID BioGRID Two-hybrid
TRAF3 BioGRID EYA3 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID PINK1 GeneID BioGRID Affinity Capture-Western; Co-localization
TRAF3 BioGRID ABCF1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID USP25 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TRADD GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID SHARPIN GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID VIRMA GeneID BioGRID Affinity Capture-RNA
TRAF3 BioGRID PRKN GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID DHX58 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID CASP2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TRAF3 BioGRID USP17L2 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID ZC3H12A GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TNF GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID E7 GeneID BioGRID PCA
TRAF3 BioGRID WDR82 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID USP1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID PRKACB GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID STK38 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TRAF3 BioGRID IL17RA GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID HNRNPC GeneID BioGRID Protein-RNA
TRAF3 BioGRID LMP-1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAF3 BioGRID CELF2 GeneID BioGRID Protein-RNA
TRAF3 BioGRID STING1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID VAV3 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID DDX3X GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TRAF3 BioGRID RNF216 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
TRAF3 BioGRID FOSL1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID SPP1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID IRF3 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TRIM14 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID MAP3K7 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
TRAF3 BioGRID TRAF1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TRAF3 BioGRID ESR1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID CREB1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID RNF166 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID FAM53C GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID IFIT3 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TRAF3IP2 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID NMRAL1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID OTUD5 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID PPP1CC GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID IKBKG GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID SYK GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID UCHL1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID SAR1A GeneID BioGRID Two-hybrid
TRAF3 BioGRID APOBEC3C GeneID BioGRID Two-hybrid
TRAF3 BioGRID RBM14 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID DCAF7 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID TROAP GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID SEC16A GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TRAF3 BioGRID MYT1 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID ABCC1 GeneID BioGRID Two-hybrid
TRAF3 BioGRID IL15 GeneID BioGRID Two-hybrid
TRAF3 BioGRID GALC GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID DAXX GeneID BioGRID Two-hybrid
TRAF3 BioGRID USO1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TRAF3 BioGRID UBE2O GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID NFATC2IP GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID ZMYND11 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TRAF3 BioGRID TRAIP GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID PPP3R1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID PPP3CA GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID PDLIM7 GeneID BioGRID PCA
TRAF3 BioGRID TNFRSF4 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID SRC GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TNFRSF9 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TRAF3 BioGRID Tnfrsf12a GeneID BioGRID Two-hybrid
TRAF3 BioGRID TNAP GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TNFRSF13C GeneID BioGRID Affinity Capture-Western; Co-crystal Structure
TRAF3 BioGRID TRAF3IP1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAF3 BioGRID TNFRSF13B GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TNFRSF11A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TRAF3 BioGRID TNFRSF1A GeneID BioGRID Reconstituted Complex
TRAF3 BioGRID MYD88 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID CBLB GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID FAS GeneID BioGRID Reconstituted Complex
TRAF3 BioGRID TNIP1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID OPTN GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TNFRSF18 GeneID BioGRID Affinity Capture-Western; Two-hybrid
TRAF3 BioGRID WDR5 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID NLRX1 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID ZBP1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
TRAF3 BioGRID AZI2 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
TRAF3 BioGRID TLR9 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID TLR3 GeneID BioGRID Affinity Capture-MS
TRAF3 BioGRID IRF1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
TRAF3 BioGRID OTUB2 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID SMURF1 GeneID BioGRID Phenotypic Suppression
TRAF3 Protein TRAF3IP3 GeneID HPRD
TRAF3 Protein GRIN1 GeneID HPRD
TRAF3 Protein TRAF3IP1 GeneID HPRD
TRAF3 Protein TICAM1 GeneID HPRD
TRAF3 Protein TRAF3IP2 GeneID HPRD
TRAF3 Protein TNFRSF13C GeneID HPRD
TRAF3 Protein TNFRSF19 GeneID HPRD
TRAF3 Protein TNFRSF12A GeneID HPRD
TRAF3 Protein NUP62 GeneID HPRD
TRAF3 Protein TDP2 GeneID HPRD
TRAF3 Protein TRIM37 GeneID HPRD
TRAF3 Protein MAP3K14 GeneID HPRD
TRAF3 Protein EDAR GeneID HPRD
TRAF3 Protein TNFRSF18 GeneID HPRD
TRAF3 Protein TANK GeneID HPRD
TRAF3 Protein TRADD GeneID HPRD
TRAF3 Protein TNFRSF11A GeneID HPRD
TRAF3 Protein RIPK1 GeneID HPRD
TRAF3 Protein TNFRSF14 GeneID HPRD
TRAF3 Protein GRIN2D GeneID HPRD
TRAF3 Protein USP7 GeneID HPRD
TRAF3 Protein TRAF5 GeneID HPRD
TRAF3 Protein TNFRSF9 GeneID HPRD
TRAF3 Protein TRAF3 GeneID HPRD
TRAF3 Protein LTBR GeneID HPRD
TRAF3 Protein CASP3 GeneID HPRD
TRAF3 Protein TNFRSF4 GeneID HPRD
TRAF3 Protein RRAS2 GeneID HPRD
TRAF3 Protein BEX3 GeneID HPRD
TRAF3 Protein EDA2R GeneID HPRD
TRAF3 Protein TNFRSF1B GeneID HPRD
TRAF3 Protein SRC GeneID HPRD
TRAF3 Protein CD27 GeneID HPRD
TRAF3 Protein MAP2K1 GeneID HPRD
TRAF3 Protein ALPL GeneID HPRD
TRAF3 Protein TNFRSF8 GeneID HPRD
TRAF3 Protein CD40 GeneID HPRD
TRAF3 Protein TNFRSF17 GeneID HPRD
TRAF3 Protein ACTA1 GeneID HPRD
TRAF3 BioGRID TRIM37 GeneID BioGRID Reconstituted Complex
TRAF3 BioGRID CD27 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TNFRSF17 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID TDP2 GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID CFLAR GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID NGFR GeneID BioGRID Affinity Capture-Western
TRAF3 BioGRID CASP3 GeneID BioGRID Biochemical Activity
TRAF3 BioGRID TNFSF14 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TRAF3 Protein TNFRSF8 GeneID BIND CRAF1 interacts with CD30.
TRAF3 None None None BIND NIK interacts with TRAF3. This interaction was modeled on a demonstrated interaction between human NIK and TRAF3 from an unspecified species.
TRAF3 Protein CD40 GeneID BIND CD40 interacts with TRAF3.
TRAF3 Protein CD40 GeneID BIND CD40 interacts with TRAF3.
TRAF3 Protein LTBR GeneID BIND TRAF3 interacts with LTBR.
StringDB
A B experiments database textmining combined score hadb nhadb
TRAF3 TLR9 157 0 602 683 1 2
TRAF3 SYNGAP1 0 0 0 327 1 1
TRAF3 ANKRA2 0 0 0 156 1 1
TRAF3 TNFSF8 0 0 294 309 1 1
TRAF3 CARD6 0 0 183 205 1 1
TRAF3 PYCARD 0 0 272 384 1 2
TRAF3 MAP3K1 0 900 641 982 1 1
TRAF3 ISY1 0 0 0 165 1 1
TRAF3 YES1 0 0 73 206 1 1
TRAF3 NLRP7 0 0 144 202 1 1
TRAF3 UBE2E2 0 0 134 265 1 1
TRAF3 HERC1 0 0 0 272 1 1
TRAF3 ERBB2 0 0 195 207 1 2
TRAF3 NEDD8-MDP1 0 0 0 150 1 1
TRAF3 UBA7 0 0 120 152 1 1
TRAF3 IRF3 486 600 802 957 1 2
TRAF3 CR2 0 0 211 211 1 1
TRAF3 GSK3A 0 0 66 329 1 1
TRAF3 OTUD7A 0 0 154 271 1 1
TRAF3 IFNGR2 0 0 156 155 1 1
TRAF3 PINK1 270 0 439 573 1 2
TRAF3 BCL6 0 0 242 258 1 1
TRAF3 UBQLN1 0 0 70 176 1 1
TRAF3 BIRC5 0 0 131 165 1 2
TRAF3 USP3 0 0 223 271 1 1
TRAF3 PPP3CA 270 0 344 569 1 1
TRAF3 INO80 0 0 0 204 1 1
TRAF3 WWOX 0 0 181 182 1 1
TRAF3 RAB21 0 0 447 447 1 1
TRAF3 C9orf89 0 0 82 179 1 1
TRAF3 BIRC8 0 0 150 183 1 1
TRAF3 PHF20 0 0 209 209 1 1
TRAF3 PIKFYVE 0 0 102 214 1 2
TRAF3 CYLD 0 0 668 714 1 1
TRAF3 USP25 270 0 661 750 1 1
TRAF3 CXCL10 0 0 376 376 1 2
TRAF3 MALT1 270 0 913 940 1 1
TRAF3 RNF103 0 0 0 157 1 1
TRAF3 HSP90AB1 0 0 52 266 1 2
TRAF3 PDLIM2 0 0 261 267 1 1
TRAF3 AXL 0 0 122 199 1 2
TRAF3 NLRC4 0 0 286 286 1 2
TRAF3 IKBKB 0 540 669 859 1 2
TRAF3 ENSG00000279392 0 0 275 394 1 1
TRAF3 MARCH8 0 0 104 162 1 1
TRAF3 HECTD4 0 0 0 272 1 1
TRAF3 XIAP 0 0 407 430 1 2
TRAF3 KMT2D 0 0 234 247 1 1
TRAF3 KCNJ6 0 0 181 181 1 1
TRAF3 DISC1 68 0 319 473 1 1
TRAF3 RNF216 486 900 260 962 1 1
TRAF3 PLXDC2 0 0 0 163 1 1
TRAF3 LY96 0 600 391 749 1 1
TRAF3 CSF2 0 0 294 294 1 1
TRAF3 SP140 0 0 244 243 1 1
TRAF3 IL17C 0 0 142 195 1 1
TRAF3 AKT1 0 0 465 526 1 2
TRAF3 UBE3A 0 0 213 271 1 1
TRAF3 PPARG 0 0 134 152 1 2
TRAF3 IL17RB 0 0 208 227 1 1
TRAF3 INPP5D 0 0 181 187 1 1
TRAF3 CD4 0 0 421 420 1 2
TRAF3 NOSIP 0 0 0 251 1 1
TRAF3 USO1 480 0 0 496 1 1
TRAF3 VCAM1 0 0 232 231 1 1
TRAF3 IFIT3 270 0 438 572 1 1
TRAF3 CARD14 0 0 138 151 1 1
TRAF3 FAS 270 0 278 450 1 2
TRAF3 ALS2 0 0 0 272 1 1
TRAF3 SUMO1 0 0 108 180 1 1
TRAF3 DDB1 0 0 108 419 1 1
TRAF3 HACE1 0 0 57 194 1 1
TRAF3 STAT5B 0 0 201 201 1 1
TRAF3 DIS3 0 0 405 413 1 1
TRAF3 BNIP3L 0 0 108 241 1 2
TRAF3 TRIM29 0 0 150 226 1 1
TRAF3 USP7 486 0 283 627 1 1
TRAF3 PRKCD 0 0 231 248 1 2
TRAF3 IFIT1 0 0 391 390 1 1
TRAF3 RIPK3 0 0 269 333 1 2
TRAF3 LRRK1 0 0 49 181 1 1
TRAF3 TICAM2 0 600 401 908 1 1
TRAF3 TBK1 937 800 989 999 1 2
TRAF3 TCHP 0 0 184 183 1 1
TRAF3 NDFIP1 0 0 134 189 1 1
TRAF3 RNF181 0 0 0 157 1 1
TRAF3 FOXP3 0 0 271 271 1 2
TRAF3 TRIM14 270 0 181 385 1 1
TRAF3 SKP1 0 0 204 204 1 2
TRAF3 USP1 270 0 72 293 1 1
TRAF3 EIF2S1 0 0 134 168 1 2
TRAF3 JAK1 0 0 518 568 1 2
TRAF3 MARCH5 0 0 232 268 1 1
TRAF3 USP17L25 0 0 181 181 1 1
TRAF3 TBPL2 0 0 67 237 1 1
TRAF3 RAC2 0 0 124 221 1 1
TRAF3 TOMM20 0 0 137 183 1 2
TRAF3 RCCD1 0 0 0 272 1 1
TRAF3 PIAS4 0 0 150 280 1 1
TRAF3 ECH1 289 0 0 288 1 1
TRAF3 TNFRSF18 500 0 268 618 1 1
TRAF3 RSAD2 0 0 267 279 1 1
TRAF3 JDP2 0 0 0 291 1 1
TRAF3 BIRC6 0 0 163 352 1 1
TRAF3 TLR3 157 600 891 967 1 2
TRAF3 UBE2C 0 0 75 252 1 1
TRAF3 LRPAP1 0 0 453 453 1 1
TRAF3 STAT6 0 0 194 194 1 1
TRAF3 EWSR1 111 0 459 508 1 1
TRAF3 TNFSF12 0 600 426 760 1 1
TRAF3 WWP2 0 0 115 180 1 1
TRAF3 EIF2AK3 0 0 181 463 1 2
TRAF3 ALYREF 0 0 218 218 1 1
TRAF3 YWHAB 0 0 81 186 1 1
TRAF3 GATA5 0 0 0 160 1 1
TRAF3 CRY1 0 0 0 324 1 1
TRAF3 BPI 0 0 57 155 1 1
TRAF3 CREB5 0 0 0 291 1 1
TRAF3 IL25 0 0 193 193 1 1
TRAF3 TNFSF11 0 600 470 778 1 2
TRAF3 EEA1 0 0 67 228 1 2
TRAF3 USP2 0 0 167 239 1 1
TRAF3 USP8 0 0 134 209 1 1
TRAF3 SMURF2 0 0 170 231 1 1
TRAF3 RAG1 0 0 181 181 1 1
TRAF3 CDC42 0 0 151 188 1 2
TRAF3 C1QBP 0 0 149 167 1 1
TRAF3 DOCK2 0 0 123 257 1 1
TRAF3 SRC 486 0 606 811 1 2
TRAF3 BRAP 0 0 0 171 1 1
TRAF3 IRF8 0 0 294 302 1 1
TRAF3 RCC2 0 0 0 207 1 1
TRAF3 CD19 0 0 260 260 1 1
TRAF3 BCL2L2 0 0 156 170 1 1
TRAF3 UBE2I 282 0 113 436 1 1
TRAF3 IFIT2 0 0 310 309 1 1
TRAF3 IRAK2 0 0 517 567 1 1
TRAF3 BLNK 0 0 224 224 1 1
TRAF3 PDLIM7 191 0 829 857 1 1
TRAF3 FAU 0 0 48 157 1 2
TRAF3 IPPK 0 0 57 171 1 1
TRAF3 RCC1 0 0 45 275 1 1
TRAF3 TRIM65 0 0 150 173 1 1
TRAF3 JUND 0 0 136 154 1 1
TRAF3 ZNF569 0 0 148 163 1 1
TRAF3 CCND1 0 0 321 321 1 2
TRAF3 CD274 0 0 217 233 1 2
TRAF3 ETV6 270 0 0 270 1 1
TRAF3 LEPREL2 0 0 112 196 1 1
TRAF3 RPS6KB1 0 0 158 169 1 2
TRAF3 BAD 0 0 103 164 1 2
TRAF3 YWHAQ 0 0 0 150 1 1
TRAF3 RNF215 0 0 0 157 1 1
TRAF3 CBL 0 0 243 254 1 1
TRAF3 IRS1 0 0 134 153 1 2
TRAF3 SAG 0 0 767 773 1 1
TRAF3 UXT 0 0 663 702 1 1
TRAF3 UBL4A 0 0 0 150 1 1
TRAF3 NTRK1 0 0 95 174 1 1
TRAF3 NUP62 270 0 0 270 1 1
TRAF3 WDR37 0 0 57 159 1 1
TRAF3 HGF 0 0 72 230 1 2
TRAF3 TRAF3IP2 675 0 843 951 1 1
TRAF3 ZSCAN32 0 0 138 153 1 1
TRAF3 RASA1 0 0 74 350 1 1
TRAF3 CCT6A 0 0 0 157 1 1
TRAF3 ZC3H12D 0 0 134 213 1 1
TRAF3 NEK6 0 0 0 151 1 1
TRAF3 TESK1 0 0 0 150 1 1
TRAF3 UBB 0 900 124 929 1 1
TRAF3 MARCH1 0 0 108 165 1 1
TRAF3 CTLA4 0 0 356 356 1 2
TRAF3 PSMA7 0 0 181 193 1 1
TRAF3 RRAS2 213 0 161 323 1 1
TRAF3 TRPS1 0 0 0 160 1 1
TRAF3 CCL19 0 0 182 215 1 1
TRAF3 DFFA 0 0 96 152 1 1
TRAF3 PTPN2 0 0 496 504 1 2
TRAF3 BAK1 0 0 120 157 1 2
TRAF3 ALPL 270 0 441 574 1 1
TRAF3 RNF38 0 0 0 157 1 1
TRAF3 SMAD6 0 0 272 282 1 1
TRAF3 MYB 0 0 151 198 1 1
TRAF3 MAP2K2 0 0 167 180 1 1
TRAF3 ATF7 0 0 0 291 1 1
TRAF3 TNFSF12-TNFSF13 0 0 184 183 1 1
TRAF3 RNASEL 0 0 324 438 1 1
TRAF3 DDX46 0 0 145 183 1 1
TRAF3 CLSTN1 0 0 65 177 1 1
TRAF3 IFI30 0 0 113 150 1 1
TRAF3 TRAF3IP3 675 0 804 933 1 1
TRAF3 NAIP 0 0 261 290 1 1
TRAF3 SMPD2 0 0 278 296 1 1
TRAF3 TPX2 0 0 0 258 1 1
TRAF3 ITCH 0 0 391 436 1 1
TRAF3 DDX3X 270 0 288 468 1 1
TRAF3 USP14 0 0 161 230 1 2
TRAF3 IL23R 0 0 150 173 1 1
TRAF3 RNF135 0 600 468 778 1 1
TRAF3 MAP4K2 0 0 166 184 1 1
TRAF3 DNAJC8 0 0 0 151 1 1
TRAF3 CDC42BPB 0 0 579 615 1 1
TRAF3 UBL7 0 0 0 150 1 1
TRAF3 TIRAP 0 0 603 603 1 1
TRAF3 TANK 870 900 989 999 1 2
TRAF3 TGDS 0 0 162 184 1 1
TRAF3 TNF 270 600 602 878 1 2
TRAF3 IFITM1 0 0 162 161 1 1
TRAF3 NBR1 0 0 91 187 1 2
TRAF3 ASCC1 249 0 0 304 1 1
TRAF3 CASP2 270 0 181 377 1 1
TRAF3 DUSP26 0 0 46 161 1 1
TRAF3 UBE2W 0 0 60 202 1 1
TRAF3 PIAS2 87 0 60 234 1 1
TRAF3 KRT37 0 0 142 162 1 1
TRAF3 HERC2 0 0 0 272 1 1
TRAF3 IL7 0 0 188 188 1 1
TRAF3 ITK 0 0 82 162 1 1
TRAF3 USP5 0 0 143 161 1 1
TRAF3 CD44 0 0 153 152 1 2
TRAF3 RETN 0 0 294 294 1 1
TRAF3 USP19 0 0 164 184 1 1
TRAF3 ATF3 0 0 96 331 1 2
TRAF3 RELT 0 0 141 166 1 1
TRAF3 GADD45A 0 0 162 161 1 1
TRAF3 IFNL1 0 0 231 230 1 1
TRAF3 IFI35 0 0 134 202 1 1
TRAF3 CCND3 0 0 171 171 1 1
TRAF3 MINK1 0 0 0 177 1 1
TRAF3 NEDD4L 0 0 75 202 1 1
TRAF3 BTK 0 800 310 868 1 1
TRAF3 SOCS1 0 0 325 332 1 1
TRAF3 RNF41 0 0 325 430 1 1
TRAF3 RFXANK 0 0 0 156 1 1
TRAF3 UBE2Z 0 0 0 186 1 1
TRAF3 IRF7 0 600 902 963 1 1
TRAF3 MAPK1 0 0 325 336 1 2
TRAF3 SOCS4 0 0 81 154 1 1
TRAF3 CSF1R 0 0 678 688 1 1
TRAF3 IL34 0 0 96 302 1 1
TRAF3 TCP1 0 0 0 161 1 1
TRAF3 NFKB2 118 0 702 751 1 1
TRAF3 TNFAIP3 0 0 556 586 1 2
TRAF3 MAP3K14 870 900 668 995 1 1
TRAF3 CD70 0 0 285 284 1 1
TRAF3 IL1R2 0 0 95 234 1 1
TRAF3 IL5 0 0 162 161 1 1
TRAF3 CCND2 0 0 151 150 1 1
TRAF3 RNF166 270 0 123 443 1 1
TRAF3 IFNAR1 0 0 460 459 1 1
TRAF3 CUL4B 0 0 0 364 1 1
TRAF3 BCL2A1 0 0 292 292 1 1
TRAF3 IFI16 0 0 375 375 1 1
TRAF3 TNFSF14 270 600 261 765 1 1
TRAF3 IFNL2 0 0 195 195 1 1
TRAF3 RELB 0 0 681 715 1 2
TRAF3 UBE2J1 0 0 96 273 1 1
TRAF3 PRKCA 0 0 181 200 1 1
TRAF3 OTUD1 0 0 212 241 1 1
TRAF3 PKN1 0 0 94 155 1 1
TRAF3 TBX21 0 0 155 154 1 1
TRAF3 RIPK4 0 0 209 328 1 1
TRAF3 MAP4K4 0 900 108 917 1 1
TRAF3 IKBKG 270 0 982 987 1 1
TRAF3 CCR7 0 0 170 169 1 1
TRAF3 PSMD14 0 0 90 152 1 1
TRAF3 FN1 0 0 171 171 1 2
TRAF3 TBP 0 0 67 157 1 1
TRAF3 AKT3 0 0 90 169 1 2
TRAF3 CXCR5 0 0 157 192 1 1
TRAF3 GALC 270 0 49 276 1 1
TRAF3 MST1R 0 0 48 213 1 1
TRAF3 TGFBR1 0 0 117 194 1 1
TRAF3 USP18 0 0 269 281 1 1
TRAF3 RCBTB2 0 0 0 272 1 1
TRAF3 VAMP3 0 0 143 166 1 1
TRAF3 CLSTN2 0 0 73 150 1 1
TRAF3 VAV1 0 0 181 214 1 1
TRAF3 DYRK1A 270 0 43 277 1 1
TRAF3 CTXN3 0 0 56 218 1 1
TRAF3 PYURF 0 0 123 189 1 1
TRAF3 ISG15 0 0 456 545 1 2
TRAF3 PIAS3 0 0 66 200 1 1
TRAF3 UBC 0 900 155 931 1 2
TRAF3 SPHK1 0 0 389 388 1 2
TRAF3 NFKBIB 0 0 391 434 1 1
TRAF3 NLRP14 0 0 0 254 1 1
TRAF3 CACUL1 0 0 0 228 1 1
TRAF3 ATG5 0 0 260 276 1 2
TRAF3 KSR1 0 0 391 444 1 1
TRAF3 MAP2K6 0 0 240 252 1 1
TRAF3 CALCOCO2 270 0 502 620 1 2
TRAF3 SH2D3A 0 0 323 386 1 1
TRAF3 EDAR 270 0 411 551 1 1
TRAF3 TLR8 0 0 518 533 1 1
TRAF3 TNIK 0 0 154 252 1 1
TRAF3 CXCR3 0 0 134 170 1 1
TRAF3 TP63 0 0 155 162 1 2
TRAF3 STAT2 0 0 456 472 1 1
TRAF3 YAP1 0 0 294 346 1 2
TRAF3 IRF1 157 0 406 482 1 2
TRAF3 GATA6 0 0 0 160 1 1
TRAF3 MIB1 0 0 0 168 1 1
TRAF3 TNFAIP2 0 0 138 215 1 1
TRAF3 PTPN1 0 0 66 215 1 1
TRAF3 PJA2 0 0 0 157 1 1
TRAF3 SIKE1 0 650 364 780 1 1
TRAF3 CTSB 0 0 156 162 1 2
TRAF3 TP53BP1 0 0 67 286 1 1
TRAF3 SPI1 0 0 171 171 1 1
TRAF3 WDR63 0 0 70 163 1 1
TRAF3 MCL1 0 0 463 463 1 2
TRAF3 IL10RB 0 0 150 157 1 1
TRAF3 AIRE 0 0 157 178 1 1
TRAF3 ITGAM 0 0 235 235 1 1
TRAF3 GATA2 0 0 67 182 1 1
TRAF3 EYA4 0 0 453 465 1 1
TRAF3 UBQLN2 0 0 0 150 1 2
TRAF3 OPTN 270 0 447 579 1 2
TRAF3 MAP3K5 270 0 341 527 1 1
TRAF3 HMGB1 0 0 184 197 1 2
TRAF3 IRF5 0 0 550 563 1 1
TRAF3 PPP1CA 0 0 175 203 1 1
TRAF3 IFNB1 0 0 708 737 1 1
TRAF3 ESR1 270 0 300 478 1 2
TRAF3 PIM2 0 0 203 219 1 1
TRAF3 COPS5 0 0 180 297 1 1
TRAF3 NSD1 0 0 155 154 1 1
TRAF3 UBE2D2 0 0 211 330 1 1
TRAF3 CTSK 0 0 234 250 1 2
TRAF3 LYN 0 0 262 326 1 1
TRAF3 ZC3H12A 270 0 450 629 1 1
TRAF3 RNF157 0 0 55 156 1 1
TRAF3 MAP3K3 0 0 212 225 1 1
TRAF3 NFKBIA 0 0 653 678 1 2
TRAF3 SYK 270 0 646 765 1 2
TRAF3 MAPK14 0 0 242 265 1 2
TRAF3 RASAL2 0 0 0 327 1 1
TRAF3 RCHY1 0 0 44 156 1 1
TRAF3 TNFRSF9 486 0 839 915 1 1
TRAF3 FCGR2A 0 0 161 161 1 1
TRAF3 MAPK10 0 900 291 931 1 2
TRAF3 CDX2 0 0 81 174 1 1
TRAF3 CD79A 0 0 204 204 1 1
TRAF3 TP53BP2 0 0 0 230 1 2
TRAF3 BAG1 0 0 150 169 1 2
TRAF3 UBA52 0 900 91 916 1 1
TRAF3 NGFR 270 0 135 354 1 1
TRAF3 TNFRSF11A 675 600 338 909 1 1
TRAF3 TRAFD1 0 0 550 560 1 1
TRAF3 BST2 0 0 256 256 1 1
TRAF3 VEGFA 0 0 203 203 1 2
TRAF3 IRF4 0 0 297 309 1 1
TRAF3 IFNA21 0 0 218 218 1 1
TRAF3 NLRP6 0 0 234 234 1 1
TRAF3 DAK 0 0 155 172 1 1
TRAF3 PLP2 0 0 340 373 1 1
TRAF3 FBXL2 0 0 211 231 1 1
TRAF3 NEK7 0 0 134 280 1 1
TRAF3 PTEN 0 0 282 293 1 2
TRAF3 TRAF7 0 0 405 280 1 1
TRAF3 CASP5 0 0 180 186 1 1
TRAF3 CNKSR1 0 0 441 441 1 1
TRAF3 NFATC1 0 0 325 325 1 2
TRAF3 DET1 0 0 0 413 1 1
TRAF3 FOSB 0 0 112 343 1 1
TRAF3 OTUD5 486 900 778 988 1 1
TRAF3 TRAT1 0 0 324 323 1 1
TRAF3 TGFBR2 0 0 103 181 1 1
TRAF3 DHX8 0 0 0 210 1 1
TRAF3 SELE 0 0 139 288 1 1
TRAF3 TRAIP 486 0 123 557 1 1
TRAF3 FOSL2 0 0 81 346 1 1
TRAF3 DLG4 0 0 0 198 1 2
TRAF3 PPP3R1 270 0 225 410 1 1
TRAF3 UBE2S 0 0 415 518 1 1
TRAF3 CCL20 0 0 233 244 1 1
TRAF3 CDK7 0 0 448 448 1 1
TRAF3 IL10 0 0 423 427 1 2
TRAF3 MRAS 0 0 459 469 1 1
TRAF3 CXCL2 0 0 193 220 1 1
TRAF3 IRAK4 0 0 806 838 1 1
TRAF3 RBPJ 0 0 112 167 1 1
TRAF3 LEPREL1 0 0 58 165 1 1
TRAF3 TYRO3 0 0 142 328 1 1
TRAF3 TRIM32 0 0 184 183 1 1
TRAF3 TOMM70A 0 0 159 165 1 1
TRAF3 ATM 0 0 259 260 1 2
TRAF3 TSPAN6 0 0 208 325 1 1
TRAF3 HLA-A 0 0 179 179 1 1
TRAF3 LITAF 0 0 140 163 1 1
TRAF3 UBE2O 270 0 53 388 1 1
TRAF3 RAD23B 0 0 0 151 1 1
TRAF3 CCL3 0 0 227 226 1 1
TRAF3 IL1RAP 270 0 63 286 1 1
TRAF3 SAMHD1 0 0 181 181 1 1
TRAF3 NLRP11 0 0 167 203 1 1
TRAF3 ZZEF1 0 0 0 272 1 1
TRAF3 CUL3 0 0 134 303 1 2
TRAF3 CHUK 0 540 977 991 1 1
TRAF3 GUSB 0 0 56 263 1 1
TRAF3 RPS27A 270 900 106 937 1 1
TRAF3 SFN 0 0 411 479 1 2
TRAF3 CASP4 0 0 181 187 1 2
TRAF3 CDKN2A 0 0 283 309 1 2
TRAF3 STAMBPL1 0 0 122 182 1 1
TRAF3 ARRB2 0 0 837 841 1 1
TRAF3 BLK 0 0 90 169 1 1
TRAF3 CDC34 0 0 134 281 1 1
TRAF3 ITGAX 0 0 207 207 1 1
TRAF3 GSK3B 0 0 60 599 1 2
TRAF3 ARRB1 0 0 637 645 1 1
TRAF3 RNF150 0 0 0 157 1 1
TRAF3 BRF2 0 0 0 177 1 1
TRAF3 LTBR 879 800 984 999 1 1
TRAF3 YWHAH 0 0 0 150 1 1
TRAF3 CSF1 0 0 218 251 1 1
TRAF3 RIPK1 406 900 668 980 1 2
TRAF3 PRDM1 0 0 324 323 1 1
TRAF3 COPS4 0 0 0 340 1 1
TRAF3 HDAC1 0 0 108 208 1 2
TRAF3 NOD2 0 0 457 478 1 2
TRAF3 ECSIT 0 0 293 410 1 1
TRAF3 CIITA 0 0 167 187 1 1
TRAF3 KIDINS220 0 0 0 224 1 1
TRAF3 HCK 0 0 88 181 1 1
TRAF3 AKAP10 0 0 0 151 1 1
TRAF3 PIK3CD 0 0 134 181 1 1
TRAF3 ATG16L1 0 0 212 212 1 2
TRAF3 CEBPB 0 0 205 218 1 2
TRAF3 UBE2L6 0 0 141 288 1 1
TRAF3 MSR1 270 0 55 280 1 1
TRAF3 TNFRSF21 0 0 218 218 1 1
TRAF3 PGLYRP1 0 0 151 150 1 1
TRAF3 TBC1D9 0 0 113 164 1 1
TRAF3 DAXX 111 0 123 192 1 1
TRAF3 CASP3 488 0 370 664 1 2
TRAF3 SMURF1 209 0 213 398 1 1
TRAF3 AICDA 0 0 205 211 1 1
TRAF3 PSMB9 0 0 156 155 1 1
TRAF3 PTGS2 0 0 181 181 1 2
TRAF3 UBE2V1 0 0 455 466 1 1
TRAF3 CXCL1 0 0 261 286 1 2
TRAF3 REL 0 0 558 558 1 2
TRAF3 NLRP3 0 0 390 556 1 2
TRAF3 MYT1 270 0 51 277 1 1
TRAF3 CYBB 0 0 150 151 1 2
TRAF3 EDA2R 674 0 544 847 1 1
TRAF3 CD28 0 0 310 309 1 1
TRAF3 TRIM56 0 0 304 304 1 1
TRAF3 CXCL5 0 0 108 185 1 1
TRAF3 ENSG00000268643 0 0 0 311 1 1
TRAF3 TNFSF13B 0 900 676 971 1 1
TRAF3 PPM1B 0 0 166 193 1 1
TRAF3 NOTCH2 0 0 164 178 1 1
TRAF3 IL13 0 0 218 218 1 2
TRAF3 TNFRSF10B 0 0 295 295 1 2
TRAF3 ATG12 0 0 212 238 1 2
TRAF3 PRKCQ 0 0 142 201 1 2
TRAF3 PIM3 0 0 57 159 1 1
TRAF3 ISY1-RAB43 0 0 0 184 1 1
TRAF3 DUSP1 0 0 218 234 1 1
TRAF3 NCCRP1 0 0 154 264 1 1
TRAF3 TLR2 0 0 520 541 1 2
TRAF3 IFITM5 0 0 95 151 1 1
TRAF3 PIAS1 0 0 134 270 1 1
TRAF3 TOLLIP 0 0 340 468 1 1
TRAF3 CDKN2C 0 0 235 263 1 1
TRAF3 LRRK2 0 0 62 192 1 2
TRAF3 MET 0 0 92 204 1 2
TRAF3 PPM1A 0 0 157 184 1 1
TRAF3 RNF130 0 0 0 157 1 1
TRAF3 BECN1 0 0 218 232 1 2
TRAF3 SDC1 0 0 242 241 1 1
TRAF3 OTUD7B 0 0 712 754 1 1
TRAF3 IL2 0 0 322 321 1 1
TRAF3 TLR6 0 0 413 471 1 1
TRAF3 WEE1 0 0 61 166 1 1
TRAF3 ZMYND11 270 0 415 554 1 1
TRAF3 CD81 0 0 157 215 1 1
TRAF3 CCT6B 0 0 57 171 1 1
TRAF3 SHARPIN 128 0 391 462 1 1
TRAF3 TFG 270 0 47 324 1 1
TRAF3 CARD11 0 0 460 468 1 1
TRAF3 UBE2E3 0 0 0 186 1 1
TRAF3 NOD1 0 0 647 672 1 2
TRAF3 IFNA17 0 0 211 211 1 1
TRAF3 IKBIP 0 0 161 176 1 1
TRAF3 CD86 0 0 320 319 1 1
TRAF3 ENSG00000277117 0 0 150 157 1 1
TRAF3 USP20 0 0 194 199 1 1
TRAF3 TBKBP1 0 0 459 480 1 1
TRAF3 RNF34 0 0 72 239 1 1
TRAF3 STAT5A 0 0 194 194 1 1
TRAF3 NKPD1 0 0 0 156 1 1
TRAF3 MCF2L 0 0 0 188 1 1
TRAF3 BIRC7 0 0 173 257 1 1
TRAF3 COPS6 0 0 0 168 1 1
TRAF3 TNIP2 0 0 233 281 1 1
TRAF3 IFNL3 0 0 213 213 1 1
TRAF3 IRAK3 0 0 340 397 1 1
TRAF3 TNIP1 270 0 420 646 1 1
TRAF3 MLEC 0 0 86 227 1 1
TRAF3 SIGIRR 0 0 180 179 1 1
TRAF3 FAF1 0 0 298 298 1 1
TRAF3 PTPN11 0 900 167 916 1 1
TRAF3 TIFA 0 0 471 490 1 1
TRAF3 PCDHB10 0 0 140 155 1 1
TRAF3 YWHAZ 0 0 709 742 1 1
TRAF3 FOS 0 0 497 628 1 2
TRAF3 FASLG 0 0 302 302 1 1
TRAF3 SOCS3 0 0 285 293 1 1
TRAF3 RSRC1 0 0 57 158 1 1
TRAF3 KRAS 0 0 324 335 1 2
TRAF3 FOXO1 0 0 171 171 1 2
TRAF3 IFNGR1 0 0 167 167 1 1
TRAF3 RNF122 0 0 134 255 1 1
TRAF3 PTH 0 0 85 292 1 1
TRAF3 NRAS 0 0 216 229 1 1
TRAF3 ZNRF3 0 0 0 157 1 1
TRAF3 RNF13 0 0 112 316 1 1
TRAF3 FKBP10 0 0 463 463 1 1
TRAF3 BTRC 0 0 274 283 1 1
TRAF3 MYO3B 0 0 0 191 1 1
TRAF3 TRIP12 0 0 0 296 1 1
TRAF3 MAPKBP1 0 0 0 202 1 1
TRAF3 PLK1 0 0 167 167 1 2
TRAF3 TNFSF18 0 0 306 306 1 1
TRAF3 TNFSF9 0 0 252 252 1 1
TRAF3 UBE2B 0 0 0 189 1 1
TRAF3 CXCL13 0 0 243 242 1 1
TRAF3 ANXA5 0 0 218 218 1 2
TRAF3 TNFSF13 0 900 170 913 1 1
TRAF3 ZC3H12C 0 0 167 243 1 1
TRAF3 WHSC1 0 0 212 212 1 1
TRAF3 HSPD1 0 0 74 167 1 1
TRAF3 GZMM 0 0 169 169 1 1
TRAF3 IFNG 0 0 143 327 1 2
TRAF3 BIRC2 677 900 988 999 1 1
TRAF3 DHX9 0 0 124 276 1 1
TRAF3 HIST2H2AC 0 0 57 200 1 1
TRAF3 CCL5 0 0 342 342 1 2
TRAF3 TNFRSF17 270 900 495 962 1 1
TRAF3 PLCG2 0 0 253 252 1 1
TRAF3 USP9X 0 0 150 165 1 1
TRAF3 CREB1 270 0 261 507 1 2
TRAF3 UBQLN4 0 0 0 150 1 1
TRAF3 FBXO3 0 0 158 210 1 1
TRAF3 KCNJ11 0 0 206 206 1 1
TRAF3 NFATC2IP 270 0 48 330 1 1
TRAF3 UBE2D3 0 0 431 517 1 1
TRAF3 TRIM9 0 0 122 155 1 1
TRAF3 CREBBP 0 0 246 356 1 1
TRAF3 TCF7L2 0 0 0 166 1 1
TRAF3 CD14 0 600 67 618 1 1
TRAF3 CD83 0 0 160 178 1 1
TRAF3 TNFSF15 0 0 157 156 1 1
TRAF3 RAP1A 0 0 893 895 1 1
TRAF3 GPS1 0 0 0 263 1 1
TRAF3 AMN 0 0 404 404 1 1
TRAF3 NF1 0 0 136 154 1 1
TRAF3 ABL1 0 0 156 230 1 1
TRAF3 MAP2K7 0 0 772 804 1 1
TRAF3 PELI2 0 0 181 229 1 1
TRAF3 TLR4 157 600 982 994 1 2
TRAF3 KSR2 0 0 74 155 1 1
TRAF3 RNF6 0 0 0 157 1 1
TRAF3 ZMAT4 0 0 66 169 1 1
TRAF3 TNFRSF25 0 0 270 287 1 1
TRAF3 ABCF1 270 0 48 291 1 1
TRAF3 GAPDH 0 0 498 498 1 2
TRAF3 NFKB1 0 0 423 524 1 2
TRAF3 LGALS3BP 270 0 0 270 1 1
TRAF3 BCL2L1 0 0 392 392 1 2
TRAF3 TRAF3IP1 486 0 954 976 1 1
TRAF3 RELA 0 0 595 626 1 2
TRAF3 ENSG00000026036 0 0 229 252 1 1
TRAF3 ZGLP1 0 0 0 160 1 1
TRAF3 USP17L28 0 0 181 181 1 1
TRAF3 CALCR 0 0 150 188 1 1
TRAF3 TRIM25 0 600 560 847 1 1
TRAF3 ZAP70 0 0 256 325 1 1
TRAF3 TLR10 0 0 277 349 1 1
TRAF3 ZRANB1 0 0 184 198 1 1
TRAF3 CLEC7A 0 0 211 211 1 1
TRAF3 USP45 0 0 57 392 1 1
TRAF3 TAB3 0 800 517 926 1 1
TRAF3 STAT4 0 0 122 273 1 1
TRAF3 TRIM4 0 0 233 232 1 1
TRAF3 IBTK 0 0 0 207 1 1
TRAF3 MCCC1 0 0 368 368 1 1
TRAF3 MYOM2 0 0 855 855 1 1
TRAF3 RNF24 0 0 0 157 1 1
TRAF3 TNFRSF1B 270 900 653 972 1 1
TRAF3 HERC5 0 0 113 190 1 1
TRAF3 B7RP1 0 0 150 157 1 1
TRAF3 IKBKE 871 800 603 996 1 1
TRAF3 HRAS 0 0 987 988 1 2
TRAF3 CTNNB1 0 0 243 292 1 2
TRAF3 IFNA4 0 0 203 203 1 1
TRAF3 EPHA2 0 0 90 169 1 1
TRAF3 EGR1 0 0 231 244 1 2
TRAF3 MFN2 0 0 137 156 1 2
TRAF3 RNF145 0 0 48 219 1 1
TRAF3 RNF11 0 0 254 362 1 1
TRAF3 KIAA1429 270 0 0 270 1 1
TRAF3 CXCL8 0 0 401 401 1 2
TRAF3 L3MBTL1 0 0 53 198 1 1
TRAF3 UBE2R2 0 0 0 204 1 1
TRAF3 UBE2G1 0 0 66 225 1 1
TRAF3 IL6R 0 0 451 451 1 1
TRAF3 OTUD3 0 0 128 200 1 1
TRAF3 NFKBID 0 0 324 349 1 1
TRAF3 PRKCB 0 0 194 213 1 2
TRAF3 BAG3 0 0 124 279 1 2
TRAF3 TRAF5 875 900 944 988 1 1
TRAF3 NEDD4 0 0 212 342 1 2
TRAF3 TRIM27 0 0 150 172 1 1
TRAF3 OAS1 0 0 174 173 1 1
TRAF3 HIF1A 0 0 154 155 1 2
TRAF3 VAV3 270 0 77 326 1 1
TRAF3 FAT1 0 0 206 219 1 1
TRAF3 IL1B 0 0 506 570 1 2
TRAF3 BCL2L2-PABPN1 0 0 150 226 1 1
TRAF3 SOCS5 0 0 107 269 1 1
TRAF3 STAT1 0 0 517 541 1 2
TRAF3 TRIM37 270 0 81 319 1 1
TRAF3 BATF2 0 0 0 291 1 1
TRAF3 TROAP 270 0 0 270 1 1
TRAF3 TNFRSF1A 270 0 834 880 1 1
TRAF3 UBE2A 0 0 0 189 1 1
TRAF3 IL17D 0 0 170 252 1 1
TRAF3 MYSM1 0 0 310 411 1 1
TRAF3 BTLA 0 0 350 349 1 1
TRAF3 NLRC3 0 0 391 406 1 1
TRAF3 USP17L27 0 0 181 181 1 1
TRAF3 IL6 0 0 525 531 1 2
TRAF3 TNFRSF19 213 0 166 332 1 1
TRAF3 ATF7-NPFF 0 0 0 291 1 1
TRAF3 NLRP1 0 0 283 282 1 1
TRAF3 MTOR 0 0 211 223 1 2
TRAF3 RAD23A 87 0 82 227 1 1
TRAF3 HNRNPLL 0 0 74 171 1 1
TRAF3 UBL4B 0 0 0 150 1 1
TRAF3 BCAR3 0 0 0 163 1 1
TRAF3 DDX21 0 0 123 244 1 1
TRAF3 ADAR 0 0 165 175 1 1
TRAF3 PIDD1 0 0 108 185 1 1
TRAF3 TRAF4 0 0 556 186 1 1
TRAF3 USP21 0 0 120 429 1 1
TRAF3 CXCR4 0 0 207 219 1 2
TRAF3 RRAS 0 0 453 463 1 1
TRAF3 NOTCH1 0 0 265 278 1 2
TRAF3 CD40LG 0 900 570 956 1 1
TRAF3 ARAF 0 0 392 445 1 1
TRAF3 NLRP4 0 0 247 265 1 1
TRAF3 HDAC2 0 0 75 179 1 1
TRAF3 MAP3K7 270 800 543 933 1 2
TRAF3 ZNF44 0 0 150 165 1 1
TRAF3 TRIM40 0 0 155 154 1 1
TRAF3 RCBTB1 0 0 0 272 1 1
TRAF3 ZBP1 157 0 352 430 1 1
TRAF3 EDA 0 0 324 456 1 1
TRAF3 EDARADD 0 0 154 219 1 1
TRAF3 LCP2 0 0 151 216 1 1
TRAF3 CRADD 0 0 139 192 1 1
TRAF3 NFKBIZ 0 0 293 319 1 1
TRAF3 TNFRSF11B 0 0 247 246 1 1
TRAF3 CSF3 0 0 167 167 1 1
TRAF3 IRAK1 0 0 985 987 1 1
TRAF3 RAF1 0 0 469 515 1 2
TRAF3 LMNA 0 0 134 173 1 2
TRAF3 CUL2 0 0 112 275 1 1
TRAF3 CARD9 0 0 289 305 1 1
TRAF3 TRAF1 486 900 944 957 1 1
TRAF3 RNF115 0 0 0 157 1 1
TRAF3 CAMP 0 0 180 179 1 2
TRAF3 DOK3 0 0 490 498 1 1
TRAF3 FADD 0 0 673 681 1 2
TRAF3 SARM1 0 900 345 932 1 1
TRAF3 C15orf41 0 0 88 150 1 1
TRAF3 FGFR3 0 0 268 290 1 1
TRAF3 NEDD8 0 0 152 249 1 2
TRAF3 CDK4 0 0 181 201 1 2
TRAF3 CFLAR 270 0 391 537 1 2
TRAF3 EGFR 0 0 310 320 1 2
TRAF3 TNFRSF4 462 0 726 856 1 1
TRAF3 MYD88 270 0 988 997 1 2
TRAF3 PPP1CC 270 0 61 296 1 1
TRAF3 FES 0 0 103 181 1 1
TRAF3 TP53 0 0 454 454 1 2
TRAF3 MDM2 0 0 247 246 1 2
TRAF3 IRF9 0 0 426 426 1 1
TRAF3 USP17L26 0 0 181 181 1 1
TRAF3 TRIM24 0 0 305 305 1 1
TRAF3 MKKS 0 0 184 286 1 1
TRAF3 PTPN22 270 0 944 958 1 1
TRAF3 RLIM 0 0 0 157 1 1
TRAF3 USP17L29 0 0 181 181 1 1
TRAF3 UBE2T 0 0 0 186 1 1
TRAF3 STAT3 0 0 391 390 1 2
TRAF3 TRIM8 0 0 194 208 1 1
TRAF3 IFNA2 0 0 203 217 1 1
TRAF3 GGCX 0 0 0 167 1 1
TRAF3 TRIM23 0 0 294 324 1 1
TRAF3 TM4SF5 0 0 0 250 1 1
TRAF3 SIVA1 0 0 180 179 1 1
TRAF3 GATA3 0 0 122 231 1 1
TRAF3 ELAVL2 0 0 0 177 1 1
TRAF3 FAM46C 0 0 505 505 1 1
TRAF3 BRF1 0 0 0 177 1 1
TRAF3 UBR5 0 0 122 186 1 1
TRAF3 BAG6 0 0 0 171 1 1
TRAF3 RNF111 0 0 48 205 1 1
TRAF3 SRSF1 0 0 126 191 1 1
TRAF3 FGR 0 0 89 168 1 1
TRAF3 RPGR 0 0 0 336 1 1
TRAF3 RNF126 0 0 0 157 1 1
TRAF3 NGFRAP1 213 0 61 243 1 1
TRAF3 NLRC5 0 0 335 352 1 1
TRAF3 JAK2 0 0 193 287 1 2
TRAF3 APAF1 0 0 193 314 1 2
TRAF3 HDAC6 0 0 108 198 1 2
TRAF3 EXOC2 0 0 366 366 1 1
TRAF3 MKNK1 0 0 46 168 1 1
TRAF3 ZFAND4 0 0 0 150 1 1
TRAF3 PTX3 0 0 60 161 1 1
TRAF3 PIK3CA 0 0 294 320 1 2
TRAF3 IL2RA 0 0 147 167 1 1
TRAF3 ACP5 0 0 234 234 1 1
TRAF3 PIM1 0 0 81 183 1 1
TRAF3 MEFV 0 0 330 330 1 1
TRAF3 EFTUD2 0 0 334 353 1 1
TRAF3 MX1 0 0 329 329 1 1
TRAF3 TAB1 0 800 556 912 1 1
TRAF3 TRAF2 805 900 972 983 1 2
TRAF3 PPP3CB 0 0 0 553 1 1
TRAF3 USP15 0 0 289 288 1 1
TRAF3 DZIP3 0 0 43 159 1 1
TRAF3 TAB2 0 800 599 929 1 2
TRAF3 SDHC 0 0 181 198 1 1
TRAF3 AZI2 157 0 329 410 1 1
TRAF3 IGF1R 0 0 144 219 1 2
TRAF3 TNFRSF6B 0 0 229 228 1 1
TRAF3 UBE2D1 0 0 280 389 1 1
TRAF3 CBLB 270 0 61 296 1 1
TRAF3 UBE2H 0 0 59 205 1 1
TRAF3 IL1R1 0 0 466 465 1 1
TRAF3 MYC 0 0 567 567 1 2
TRAF3 RNF125 0 0 459 513 1 1
TRAF3 IL15 111 0 251 314 1 1
TRAF3 ARR3 0 0 272 288 1 1
TRAF3 RALGDS 0 0 245 260 1 1
TRAF3 ILK 0 0 0 256 1 1
TRAF3 IL18 0 0 370 383 1 2
TRAF3 IFNA1 0 0 600 600 1 1
TRAF3 PARK2 270 0 134 382 1 1
TRAF3 CD80 0 0 324 323 1 2
TRAF3 CCL21 0 0 139 158 1 1
TRAF3 NLRP12 0 0 968 968 1 1
TRAF3 RBCK1 0 0 394 425 1 1
TRAF3 OASL 0 0 107 230 1 1
TRAF3 USP38 0 0 136 154 1 1
TRAF3 FURIN 0 0 155 176 1 1
TRAF3 MAGI1 0 0 130 213 1 1
TRAF3 DHX58 270 0 600 705 1 1
TRAF3 UBBP4 0 0 0 258 1 1
TRAF3 MAP3K8 0 0 322 332 1 1
TRAF3 CARD10 0 0 160 173 1 1
TRAF3 MAP2K1 213 0 523 614 1 1
TRAF3 TLR1 0 0 466 519 1 1
TRAF3 MARCH7 0 0 140 200 1 1
TRAF3 WDR62 0 0 0 202 1 1
TRAF3 PPP1R13B 0 0 0 234 1 1
TRAF3 AKT2 0 0 113 202 1 2
TRAF3 UBE2K 0 0 134 265 1 1
TRAF3 DAB2IP 0 0 0 327 1 2
TRAF3 IL17RC 0 0 701 701 1 1
TRAF3 TNFRSF13B 270 0 795 846 1 1
TRAF3 CASP10 0 0 241 290 1 1
TRAF3 TAX1BP1 270 0 615 727 1 2
TRAF3 ZNF501 0 0 150 165 1 1
TRAF3 SEC16A 270 0 400 551 1 2
TRAF3 ZC3H12B 0 0 182 257 1 1
TRAF3 UBD 0 0 202 293 1 1
TRAF3 PPP3CC 0 0 0 171 1 1
TRAF3 TNFRSF12A 213 600 545 844 1 1
TRAF3 NOL3 0 0 112 167 1 1
TRAF3 CD79B 0 0 261 261 1 1
TRAF3 BRAF 270 0 328 547 1 2
TRAF3 MAP2K4 0 0 267 281 1 1
TRAF3 PCM1 0 0 0 170 1 1
TRAF3 IGHV4-38-2 0 0 325 325 1 1
TRAF3 MAPK8 0 900 492 950 1 2
TRAF3 TDP2 270 0 388 538 1 1
TRAF3 CSK 0 0 710 743 1 1
TRAF3 CISH 0 0 292 300 1 1
TRAF3 PRF1 0 0 164 163 1 1
TRAF3 UBQLNL 0 0 0 150 1 1
TRAF3 FKBP1A 0 0 241 241 1 2
TRAF3 OTUB1 675 600 896 985 1 1
TRAF3 BATF3 0 0 0 291 1 1
TRAF3 TUFM 0 0 150 222 1 2
TRAF3 DIABLO 0 540 459 740 1 2
TRAF3 IFIH1 0 600 766 916 1 1
TRAF3 DDX1 0 0 143 245 1 1
TRAF3 ISG20 0 0 203 203 1 1
TRAF3 HSP90B1 0 0 112 165 1 1
TRAF3 TUBD1 0 0 60 157 1 1
TRAF3 NGB 0 0 214 237 1 1
TRAF3 RNF32 0 0 0 157 1 1
TRAF3 NEK9 0 0 0 284 1 1
TRAF3 CXCL9 0 0 203 203 1 1
TRAF3 USP22 0 0 112 150 1 1
TRAF3 HSPA4 0 0 233 244 1 1
TRAF3 IRF2 0 0 180 231 1 1
TRAF3 GATA4 0 0 0 160 1 2
TRAF3 PCBP2 0 0 335 335 1 1
TRAF3 USP29 0 0 117 154 1 1
TRAF3 PIK3R1 0 0 166 165 1 1
TRAF3 TRIM5 0 0 217 217 1 1
TRAF3 EGF 0 0 282 368 1 2
TRAF3 IL17A 0 0 406 406 1 2
TRAF3 RNF19A 0 0 128 173 1 1
TRAF3 BFAR 0 0 92 167 1 1
TRAF3 RASAL3 0 0 0 327 1 1
TRAF3 PELI1 0 0 400 444 1 1
TRAF3 CLSPN 0 0 45 370 1 1
TRAF3 TRAF6 0 900 989 940 1 2
TRAF3 CASP9 0 0 234 235 1 2
TRAF3 RNF144B 270 0 52 374 1 1
TRAF3 CXCL11 0 0 160 181 1 1
TRAF3 ZNF7 0 0 154 168 1 1
TRAF3 MAPK9 0 900 160 918 1 2
TRAF3 DHX36 0 0 218 253 1 1
TRAF3 TLR7 0 0 612 652 1 2
TRAF3 LCA5 0 0 0 154 1 1
TRAF3 DUSP12 0 0 124 172 1 1
TRAF3 CYCS 0 0 231 247 1 2
TRAF3 CRY2 0 0 0 324 1 1
TRAF3 BIRC3 675 900 946 998 1 1
TRAF3 SEC63 0 0 0 167 1 1
TRAF3 IL17F 0 0 233 232 1 1
TRAF3 TNFRSF10A 0 0 278 278 1 1
TRAF3 ZMIZ1 0 0 67 201 1 1
TRAF3 OTUD6A 0 0 108 163 1 1
TRAF3 LEF1 0 0 70 191 1 1
TRAF3 UBQLN3 0 0 0 150 1 1
TRAF3 EP300 0 0 204 298 1 2
TRAF3 IL4 0 0 322 321 1 1
TRAF3 ZNF436 0 0 150 165 1 1
TRAF3 DCAF7 270 0 0 312 1 1
TRAF3 UBE2U 0 0 0 189 1 1
TRAF3 IL17RE 0 0 216 216 1 1
TRAF3 CUL1 0 0 181 341 1 1
TRAF3 CASP7 0 0 184 185 1 1
TRAF3 USP28 0 0 88 388 1 1
TRAF3 TYROBP 0 0 170 169 1 1
TRAF3 BBS10 0 0 0 161 1 1
TRAF3 ELAVL1 0 0 81 153 1 2
TRAF3 CD276 0 0 268 268 1 1
TRAF3 ZMIZ2 0 0 0 199 1 1
TRAF3 RNF44 0 0 0 157 1 1
TRAF3 OTULIN 0 0 294 340 1 1
TRAF3 CCL2 0 0 325 325 1 2
TRAF3 CDC37 63 0 0 165 1 1
TRAF3 LRRFIP1 0 0 118 159 1 1
TRAF3 CASP8 0 0 508 539 1 2
TRAF3 ALB 0 0 222 228 1 2
TRAF3 IL1A 0 0 261 261 1 1
TRAF3 CCL4 0 0 202 202 1 1
TRAF3 MAVS 917 800 989 999 1 2
TRAF3 CUL5 0 0 120 282 1 1
TRAF3 CHMP3 0 0 0 157 1 1
TRAF3 TRADD 469 800 899 991 1 1
TRAF3 USP17L24 0 0 181 181 1 1
TRAF3 FKBP5 0 0 742 742 1 1
TRAF3 MAP3K11 0 0 118 195 1 1
TRAF3 GATA1 0 0 0 160 1 1
TRAF3 RNF31 0 540 467 754 1 1
TRAF3 COPS3 0 0 0 163 1 1
TRAF3 MAF 0 0 233 232 1 1
TRAF3 TRIM21 0 0 261 261 1 1
TRAF3 ZNF763 0 0 150 165 1 1
TRAF3 IL17RD 0 0 195 208 1 1
TRAF3 NCF4 0 0 456 456 1 1
TRAF3 BCL2L10 0 0 181 181 1 1
TRAF3 MB21D1 0 0 458 457 1 1
TRAF3 PRKCZ 0 0 83 163 1 1
TRAF3 OTUB2 270 600 428 825 1 1
TRAF3 UBXN1 0 0 370 394 1 1
TRAF3 YWHAG 0 0 457 520 1 1
TRAF3 UBE2D4 0 0 0 186 1 1
TRAF3 DDX41 0 0 322 321 1 1
TRAF3 DDX58 270 600 953 985 1 1
TRAF3 AIM2 0 0 392 392 1 2
TRAF3 CDK6 0 0 142 163 1 2
TRAF3 UBE2N 0 0 868 888 1 1
TRAF3 GMEB1 270 0 57 282 1 1
TRAF3 CXCL12 0 0 182 181 1 2
TRAF3 RNF43 0 0 0 157 1 1
TRAF3 N4BP1 0 0 97 179 1 1
TRAF3 TLR5 0 0 452 462 1 1
TRAF3 RBM14 270 0 0 280 1 1
TRAF3 UBE2L3 0 0 275 394 1 1
TRAF3 BID 0 0 123 263 1 2
TRAF3 IFNAR2 0 0 314 313 1 1
TRAF3 SPP1 270 0 203 393 1 2
TRAF3 NKRF 0 0 430 440 1 1
TRAF3 NMRAL1 270 0 294 467 1 1
TRAF3 PJA1 0 0 0 157 1 1
TRAF3 TCF7L1 0 0 0 166 1 1
TRAF3 TNFRSF14 270 0 448 586 1 1
TRAF3 ENSG00000249884 0 0 0 157 1 1
TRAF3 ATG9A 0 0 0 236 1 2
TRAF3 RALB 0 0 326 337 1 2
TRAF3 USP16 0 0 0 260 1 1
TRAF3 ICAM1 0 0 317 317 1 2
TRAF3 UNC93B1 0 0 595 609 1 1
TRAF3 PTPRC 0 0 253 264 1 1
TRAF3 CD160 0 0 396 396 1 1
TRAF3 TRIM31 0 0 217 217 1 1
TRAF3 UBAP1 0 0 54 169 1 1
TRAF3 BCL10 0 0 454 465 1 1
TRAF3 MLKL 0 0 195 265 1 2
TRAF3 SMDT1 0 0 181 181 1 1
TRAF3 MUL1 0 0 143 181 1 2
TRAF3 ATF2 0 0 134 360 1 1
TRAF3 CRP 0 0 97 235 1 2
TRAF3 WDR82 270 0 66 346 1 1
TRAF3 HTRA2 0 540 95 565 1 1
TRAF3 HPGDS 0 0 216 228 1 1
TRAF3 FBXW7 0 0 203 218 1 2
TRAF3 BCL3 0 0 137 266 1 1
TRAF3 FOSL1 270 0 95 490 1 1
TRAF3 LTB 0 600 264 712 1 1
TRAF3 HSP90AA1 0 0 508 534 1 2
TRAF3 LBP 0 0 95 157 1 1
TRAF3 MPND 0 0 66 164 1 1
TRAF3 RNF5 0 0 269 285 1 1
TRAF3 TRAM1 0 0 135 194 1 1
TRAF3 FCGR2B 0 0 143 161 1 1
TRAF3 SQSTM1 0 0 205 284 1 2
TRAF3 MAPK3 0 0 375 386 1 2
TRAF3 STK38 270 0 552 694 1 1
TRAF3 MMP9 0 0 212 212 1 2
TRAF3 B2M 0 0 155 154 1 1
TRAF3 FAM53C 245 0 0 244 1 1
TRAF3 BRCC3 0 0 108 187 1 1
TRAF3 CSNK1E 270 0 0 270 1 1
TRAF3 CUL4A 0 0 52 371 1 1
TRAF3 EPRS 0 0 0 368 1 1
TRAF3 DNMT1 0 0 90 256 1 2
TRAF3 NLRX1 270 0 666 758 1 2
TRAF3 STUB1 0 0 450 531 1 2
TRAF3 CD40 981 900 989 999 1 2
TRAF3 UBE2E1 0 0 135 266 1 1
TRAF3 ACTB 0 0 420 437 1 2
TRAF3 ATG13 0 0 451 451 1 2
TRAF3 INS 0 0 181 181 1 2
TRAF3 SELP 0 0 81 240 1 1
TRAF3 USP17L2 270 0 167 365 1 1
TRAF3 TNFSF10 0 0 291 290 1 2
TRAF3 MST4 0 0 120 166 1 1
TRAF3 JAK3 0 0 540 622 1 1
TRAF3 MAP2K3 0 0 697 702 1 1
TRAF3 SH2D3C 0 0 283 381 1 1
TRAF3 USP17L30 0 0 181 181 1 1
TRAF3 GHDC 0 0 53 205 1 1
TRAF3 TRIM38 0 0 324 328 1 1
TRAF3 SNAP29 492 0 0 499 1 2
TRAF3 CD27 486 0 627 804 1 1
TRAF3 ZSWIM2 0 0 0 157 1 1
TRAF3 MYO3A 0 0 0 191 1 1
TRAF3 CASP1 0 0 405 412 1 2
TRAF3 PLCG1 0 0 184 183 1 1
TRAF3 JUN 0 0 556 565 1 2
TRAF3 RNF165 0 0 0 175 1 1
TRAF3 BATF 0 0 124 352 1 1
TRAF3 TAPBP 0 0 135 183 1 1
TRAF3 TNIP3 0 0 234 239 1 1
TRAF3 TMEM173 486 0 469 715 1 1
TRAF3 MAFB 0 0 193 193 1 1
TRAF3 ZNF629 0 0 150 165 1 1
TRAF3 TRIM11 0 0 142 218 1 1
TRAF3 TYK2 0 0 373 428 1 1
TRAF3 DAPK1 0 0 103 174 1 2
TRAF3 FBXO4 0 0 58 185 1 1
TRAF3 IL10RA 0 0 154 153 1 1
TRAF3 WDR5 270 0 74 343 1 1
TRAF3 BCL2L11 0 0 235 235 1 2
TRAF3 ENSG00000173366 0 0 687 717 1 1
TRAF3 AMFR 0 0 143 195 1 1
TRAF3 USP4 0 0 325 325 1 1
TRAF3 LTA 0 900 167 922 1 1
TRAF3 MIB2 0 0 274 386 1 1
TRAF3 TTC3 0 0 55 170 1 1
TRAF3 OTUD4 0 0 90 178 1 1
TRAF3 DTX4 0 0 269 285 1 1
TRAF3 FYN 0 0 206 275 1 1
TRAF3 NFKBIE 0 0 407 445 1 1
TRAF3 TICAM1 766 800 961 998 1 2
TRAF3 PELI3 0 0 173 237 1 1
TRAF3 GRB2 0 0 319 329 1 1
TRAF3 CD37 0 0 0 189 1 1
TRAF3 IL17RA 270 0 976 984 1 1
TRAF3 SERGEF 0 0 0 272 1 1
TRAF3 IFNK 0 0 0 213 1 1
TRAF3 LCK 0 0 272 335 1 1
TRAF3 YWHAE 0 0 162 258 1 1
TRAF3 TCF7 0 0 0 166 1 1
TRAF3 RIPK2 270 800 963 994 1 2
TRAF3 TNFRSF8 688 0 930 977 1 1
TRAF3 TNFSF4 0 0 240 239 1 1
TRAF3 PRKACB 270 0 285 492 1 1
TRAF3 CNPY3 0 0 195 195 1 1
TRAF3 TNFRSF13C 817 800 988 999 1 1
TRAF3 WBSCR16 0 0 0 272 1 1
TRAF3 EIF2AK2 0 0 140 436 1 2
TRAF3 NRK 0 0 0 152 1 1
TRAF3 SH3RF2 0 0 54 224 1 1
TRAF3 PSMB8 113 0 112 188 1 1
TRAF3 USP50 0 0 211 230 1 1
TRAF3 BIK 0 0 125 165 1 2
TRAF3 WDFY1 0 0 66 153 1 1
TRAF3 CD8A 0 0 403 403 1 1
TRAF3 UCHL1 270 0 457 587 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0005515 Molecular Function protein binding enables IPI
GO:0019901 Molecular Function protein kinase binding enables IEA
GO:0019903 Molecular Function protein phosphatase binding enables IPI
GO:0031996 Molecular Function thioesterase binding enables IPI
GO:0005164 Molecular Function tumor necrosis factor receptor binding enables IPI
GO:0061630 Molecular Function ubiquitin protein ligase activity enables IDA
GO:0031625 Molecular Function ubiquitin protein ligase binding enables IBA
GO:0031625 Molecular Function ubiquitin protein ligase binding enables IPI
GO:0004842 Molecular Function ubiquitin-protein transferase activity enables IDA
GO:0004842 Molecular Function ubiquitin-protein transferase activity enables TAS
GO:0008270 Molecular Function zinc ion binding enables IEA
GO:0035666 Biological Process TRIF-dependent toll-like receptor signaling pathway involved_in TAS
GO:0008063 Biological Process Toll signaling pathway involved_in IEA
GO:0006915 Biological Process apoptotic process involved_in IEA
GO:0051607 Biological Process defense response to virus involved_in NAS
GO:0032088 Biological Process negative regulation of NF-kappaB transcription factor activity involved_in IBA
GO:0032088 Biological Process negative regulation of NF-kappaB transcription factor activity involved_in IMP
GO:0032481 Biological Process positive regulation of type I interferon production involved_in IDA
GO:0070534 Biological Process protein K63-linked ubiquitination involved_in IBA
GO:0042981 Biological Process regulation of apoptotic process involved_in IEA
GO:0043122 Biological Process regulation of canonical NF-kappaB signal transduction involved_in IBA
GO:0001817 Biological Process regulation of cytokine production involved_in ISS
GO:0050688 Biological Process regulation of defense response to virus involved_in ISS
GO:0032648 Biological Process regulation of interferon-beta production involved_in ISS
GO:0030162 Biological Process regulation of proteolysis involved_in IMP
GO:0007165 Biological Process signal transduction involved_in TAS
GO:0002224 Biological Process toll-like receptor signaling pathway involved_in ISS
GO:0033209 Biological Process tumor necrosis factor-mediated signaling pathway involved_in IBA
GO:0033209 Biological Process tumor necrosis factor-mediated signaling pathway involved_in IMP
GO:0060337 Biological Process type I interferon-mediated signaling pathway involved_in NAS
GO:0035631 Cellular Component CD40 receptor complex part_of ISS
GO:0009898 Cellular Component cytoplasmic side of plasma membrane located_in ISS
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005768 Cellular Component endosome is_active_in IDA
GO:0005739 Cellular Component mitochondrion is_active_in IC
GO:0005739 Cellular Component mitochondrion is_active_in IDA
GO:0098802 Cellular Component plasma membrane signaling receptor complex part_of IBA
GO:1902554 Cellular Component serine/threonine protein kinase complex part_of NAS
GO:0000151 Cellular Component ubiquitin ligase complex part_of NAS
Pathways
Name DB ID
Cytokine Signaling in Immune system Reactome R-HSA-1280215
Disease Reactome R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade Reactome R-HSA-166016
MyD88-independent TLR4 cascade Reactome R-HSA-166166
Toll Like Receptor 3 (TLR3) Cascade Reactome R-HSA-168164
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Toll-like Receptor Cascades Reactome R-HSA-168898
DDX58/IFIH1-mediated induction of interferon-alpha/beta Reactome R-HSA-168928
Metabolism of proteins Reactome R-HSA-392499
Diseases of Immune System Reactome R-HSA-5260271
Diseases associated with the TLR signaling cascade Reactome R-HSA-5602358
TRAF3 deficiency - HSE Reactome R-HSA-5602571
Infectious disease Reactome R-HSA-5663205
TNFR2 non-canonical NF-kB pathway Reactome R-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Reactome R-HSA-5676594
Deubiquitination Reactome R-HSA-5688426
Ovarian tumor domain proteases Reactome R-HSA-5689896
Post-translational protein modification Reactome R-HSA-597592
TICAM1-dependent activation of IRF3/IRF7 Reactome R-HSA-9013973
TRAF3-dependent IRF activation pathway Reactome R-HSA-918233
Negative regulators of DDX58/IFIH1 signaling Reactome R-HSA-936440
Activation of IRF3, IRF7 mediated by TBK1, IKBKE Reactome R-HSA-936964
TRIF(TICAM1)-mediated TLR4 signaling Reactome R-HSA-937061
SARS-CoV-1 Infection Reactome R-HSA-9678108
SARS-CoV Infections Reactome R-HSA-9679506
SARS-CoV-1-host interactions Reactome R-HSA-9692914
SARS-CoV-1 activates/modulates innate immune responses Reactome R-HSA-9692916
SARS-CoV-2 Infection Reactome R-HSA-9694516
SARS-CoV-2 activates/modulates innate and adaptive immune responses Reactome R-HSA-9705671
SARS-CoV-2-host interactions Reactome R-HSA-9705683
Viral Infection Pathways Reactome R-HSA-9824446
TLR4 signaling and tolerance (WP3851) WikiPathways WP3851_r121712
Network map of SARS-CoV-2 signaling pathway (WP5115) WikiPathways WP5115_r124648
2q37 copy number variation syndrome (WP5224) WikiPathways WP5224_r122740
Measles virus infection (WP4630) WikiPathways WP4630_r123414
Hepatitis B infection (WP4666) WikiPathways WP4666_r123495
Toll-like receptor signaling related to MyD88 (WP3858) WikiPathways WP3858_r117850
SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation (WP5116) WikiPathways WP5116_r124652
SARS coronavirus and innate immunity (WP4912) WikiPathways WP4912_r124650
Type I interferon induction and signaling during SARS-CoV-2 infection (WP4868) WikiPathways WP4868_r124657
SARS-CoV-2 innate immunity evasion and cell-specific immune response (WP5039) WikiPathways WP5039_r124653
miRNAs involvement in the immune response in sepsis (WP4329) WikiPathways WP4329_r123505
Oxidative damage response (WP3941) WikiPathways WP3941_r123242
Toll-like receptor signaling pathway (WP75) WikiPathways WP75_r119233
Mitochondrial immune response to SARS-CoV-2 (WP5038) WikiPathways WP5038_r124641
Small cell lung cancer (WP4658) WikiPathways WP4658_r124606
Activation of NLRP3 inflammasome by SARS-CoV-2 (WP4876) WikiPathways WP4876_r124661
SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction (WP5183) WikiPathways WP5183_r124655
Apoptosis (WP254) WikiPathways WP254_r118382
Head and neck squamous cell carcinoma (WP4674) WikiPathways WP4674_r123494
TNF-related weak inducer of apoptosis (TWEAK) signaling pathway (WP2036) WikiPathways WP2036_r120940
Apoptosis modulation and signaling (WP1772) WikiPathways WP1772_r120736
RANKL/RANK signaling pathway (WP2018) WikiPathways WP2018_r120672
Host-pathogen interaction of human coronaviruses - interferon induction (WP4880) WikiPathways WP4880_r124638
IL-17 signaling pathway (WP2112) WikiPathways WP2112_r117960
Novel intracellular components of RIG-I-like receptor pathway (WP3865) WikiPathways WP3865_r123636
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_145725 3 mRNA transcript variant 1 NC_000014 Reference
NM_001385142 1 mRNA transcript variant 5 NC_000014 Reference
NM_145726 3 mRNA transcript variant 2 NC_000014 Reference
XM_011537117 4 mRNA transcript variant X8 NC_000014 Reference
NM_001385143 1 mRNA transcript variant 6 NC_000014 Reference
XM_011537116 4 mRNA transcript variant X6 NC_000014 Reference
XM_011537118 4 mRNA transcript variant X11 NC_000014 Reference
NM_003300 4 mRNA transcript variant 3 NC_000014 Reference
XM_047431739 1 mRNA transcript variant X5 NC_000014 Reference
XM_047431742 1 mRNA transcript variant X10 NC_000014 Reference
XM_047431740 1 mRNA transcript variant X7 NC_000014 Reference
NM_001199427 2 mRNA transcript variant 4 NC_000014 Reference
XM_017021620 3 mRNA transcript variant X12 NC_000014 Reference
XM_017021617 2 mRNA transcript variant X2 NC_000014 Reference
XM_047431738 1 mRNA transcript variant X3 NC_000014 Reference
XM_017021618 2 mRNA transcript variant X1 NC_000014 Reference
XM_017021619 2 mRNA transcript variant X4 NC_000014 Reference
XM_047431741 1 mRNA transcript variant X9 NC_000014 Reference