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TRPM2

transient receptor potential cation channel subfamily M member 2
General Information
Name transient receptor potential cation channel subfamily M member 2
Alias
  • transient receptor potential cation channel subfamily M member 2
  • estrogen-responsive element-associated gene 1 protein
  • long transient receptor potential channel 2
  • transient receptor potential channel 7
  • transient receptor potential melastatin 2
Gene_family Nudix hydrolase family|Transient receptor potential cation channels
organism Homo sapiens
entrez_id 7226
location 21q22.3
transcript_count 10
exon_count 35
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
    Stringdb Transient receptor potential cation channel subfamily M member 2; Isoform 1: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Extracellular calcium passes through the channel and increases channel activity by binding to the cytoplasmic domain and stabilizing the channel in an open conformation. Also contributes to Ca(2+) release from intracellular stores in response to ADP-ribose. Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates t [...]
    nextProt Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP-ribose.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
TRPM2 BioGRID RAF1 GeneID BioGRID Affinity Capture-MS
TRPM2 BioGRID HDLBP GeneID BioGRID Affinity Capture-MS
TRPM2 BioGRID TRIM21 GeneID BioGRID Affinity Capture-Western
TRPM2 BioGRID TRPM2 GeneID BioGRID Affinity Capture-Western
TRPM2 BioGRID EFHC1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
TRPM2 BioGRID PPP1R12A GeneID BioGRID Affinity Capture-MS
TRPM2 BioGRID HNRNPL GeneID BioGRID Affinity Capture-RNA
TRPM2 Protein TRPC6 GeneID HPRD
TRPM2 Protein ITPR3 GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
TRPM2 PIK3R5 0 0 0 154 1 1
TRPM2 ATP2A1 0 0 81 158 1 1
TRPM2 MAGI3 0 0 0 208 1 1
TRPM2 AK7 0 0 0 157 1 1
TRPM2 SIGLEC9 0 0 0 165 1 1
TRPM2 NMNAT2 0 0 208 226 1 1
TRPM2 AGER 0 0 171 270 1 2
TRPM2 SIRT6 0 0 233 232 1 2
TRPM2 VPS35 0 0 52 222 1 2
TRPM2 ADAP1 0 0 0 162 1 1
TRPM2 BAI2 0 0 143 214 1 1
TRPM2 NCF4 0 0 43 179 1 1
TRPM2 TPTE 0 0 122 155 1 1
TRPM2 IPO5 0 0 0 208 1 1
TRPM2 THADA 0 0 0 216 1 1
TRPM2 NRDE2 0 0 392 392 1 1
TRPM2 FER1L6 0 0 0 156 1 1
TRPM2 GLRA4 0 0 0 158 1 1
TRPM2 RNF123 0 0 0 209 1 1
TRPM2 CPNE9 0 0 0 171 1 1
TRPM2 WSCD2 0 0 74 184 1 1
TRPM2 CSMD2 0 0 310 325 1 1
TRPM2 SGK2 0 0 0 152 1 1
TRPM2 ALB 0 0 154 153 1 2
TRPM2 TPRN 0 0 141 193 1 1
TRPM2 PGK1 0 0 64 157 1 2
TRPM2 KAT2A 0 0 46 153 1 1
TRPM2 TYROBP 0 0 0 281 1 1
TRPM2 MPPED1 0 0 0 207 1 1
TRPM2 HSP90B1 0 0 0 199 1 1
TRPM2 TRPC6 213 0 675 645 1 1
TRPM2 ITPR1 0 0 294 562 1 2
TRPM2 CYCS 0 0 113 366 1 2
TRPM2 OLFM4 0 0 57 304 1 1
TRPM2 RASAL3 0 0 0 171 1 1
TRPM2 SUMO3 0 0 90 230 1 1
TRPM2 LILRB2 0 0 0 157 1 1
TRPM2 VR1 0 0 606 692 1 1
TRPM2 STIM2 0 0 540 611 1 1
TRPM2 P2RX7 0 0 205 228 1 2
TRPM2 RPS6KB2 0 0 0 194 1 2
TRPM2 GPD1L 0 0 81 166 1 1
TRPM2 AK9 0 0 0 178 1 1
TRPM2 FKBP1A 0 0 329 329 1 2
TRPM2 CCR1 0 0 0 152 1 1
TRPM2 ANK1 0 0 212 287 1 1
TRPM2 CCR5 0 0 47 157 1 1
TRPM2 TRPC5 0 0 720 490 1 1
TRPM2 TRPM6 0 0 619 229 1 1
TRPM2 MCOLN3 0 0 466 583 1 1
TRPM2 SIGLEC7 0 0 0 152 1 1
TRPM2 MCOLN2 0 0 420 547 1 1
TRPM2 TRPC7 0 0 0 303 1 1
TRPM2 NUDT21 0 0 94 330 1 1
TRPM2 PKD2L2 0 0 518 548 1 1
TRPM2 CPSF6 0 0 72 232 1 1
TRPM2 NUDT2 0 0 0 162 1 1
TRPM2 PLCH2 0 0 0 150 1 1
TRPM2 TREM2 0 0 0 151 1 1
TRPM2 ENSG00000270024 0 0 0 163 1 1
TRPM2 CD74 0 0 60 171 1 1
TRPM2 SNCA 0 0 72 169 1 2
TRPM2 CASP1 0 0 246 282 1 2
TRPM2 TNFSF10 0 0 74 158 1 2
TRPM2 AIF1 0 0 114 208 1 2
TRPM2 PIK3CG 0 0 52 166 1 1
TRPM2 SERPINB2 0 0 46 185 1 1
TRPM2 KCNN1 0 0 0 155 1 1
TRPM2 PLCB4 0 0 0 158 1 1
TRPM2 KIAA1958 0 0 0 156 1 1
TRPM2 SIGLEC1 0 0 0 177 1 1
TRPM2 SERPINA1 0 0 0 178 1 2
TRPM2 KCNK3 0 0 91 203 1 1
TRPM2 ITPR3 213 0 305 679 1 1
TRPM2 PLCG1 0 0 108 211 1 1
TRPM2 NUDT8 0 0 0 206 1 1
TRPM2 LRRC3 0 0 167 167 1 1
TRPM2 HSP90AA1 0 0 0 371 1 2
TRPM2 CALHM1 0 0 0 256 1 1
TRPM2 TFEB 0 0 151 321 1 2
TRPM2 VPS13C 0 0 0 153 1 1
TRPM2 AK5 0 0 0 165 1 1
TRPM2 PSEN1 0 0 157 156 1 2
TRPM2 PKD1L3 0 0 123 177 1 1
TRPM2 KCNT1 0 0 59 164 1 1
TRPM2 ACTB 0 0 171 202 1 2
TRPM2 AK2 0 0 0 157 1 1
TRPM2 INS 0 0 232 231 1 2
TRPM2 GLO1 0 0 0 182 1 1
TRPM2 SIRT3 0 0 181 181 1 2
TRPM2 MCEE 0 0 0 182 1 1
TRPM2 PARP1 0 0 390 390 1 2
TRPM2 ABTB1 0 0 0 151 1 1
TRPM2 NUDT4 0 0 0 162 1 1
TRPM2 TCF7L1 0 0 66 314 1 1
TRPM2 MOSPD3 0 0 72 169 1 1
TRPM2 FYB 0 0 0 193 1 1
TRPM2 PHPT1 0 0 108 204 1 1
TRPM2 PTPRC 0 0 0 153 1 1
TRPM2 EFHC1 270 0 0 381 1 1
TRPM2 GPR84 0 0 0 171 1 1
TRPM2 TMC2 0 0 0 173 1 1
TRPM2 SIRT7 0 0 182 181 1 2
TRPM2 MPO 0 0 158 229 1 2
TRPM2 MYSM1 0 0 0 164 1 1
TRPM2 PPP1R12A 182 0 0 211 1 1
TRPM2 NUDT3 0 0 0 162 1 1
TRPM2 IL6 0 0 204 204 1 2
TRPM2 ART1 0 0 194 194 1 1
TRPM2 PLEK 0 0 45 163 1 1
TRPM2 KCNMA1 0 0 74 174 1 1
TRPM2 AK8 0 0 0 178 1 1
TRPM2 PTPN13 0 0 448 448 1 1
TRPM2 TRPV6 0 0 524 636 1 1
TRPM2 CALM1 0 0 358 407 1 1
TRPM2 NUDT14 0 0 62 353 1 1
TRPM2 FCGR3A 0 0 47 205 1 1
TRPM2 DMTN 0 0 0 158 1 1
TRPM2 TRPV1 0 0 606 692 1 2
TRPM2 APP 0 0 167 185 1 2
TRPM2 ARL8A 0 0 0 281 1 1
TRPM2 C3AR1 0 0 60 212 1 1
TRPM2 RNF24 0 0 728 730 1 1
TRPM2 HERC5 0 0 60 179 1 1
TRPM2 CACNA1C 0 0 411 424 1 1
TRPM2 MS4A4A 0 0 0 175 1 1
TRPM2 CACNG3 0 0 0 167 1 1
TRPM2 SIRT5 0 0 195 195 1 1
TRPM2 PKD1L1 0 0 89 173 1 1
TRPM2 TRPM7 0 800 688 841 1 1
TRPM2 AK4 0 0 0 157 1 1
TRPM2 CMPK1 0 0 0 165 1 1
TRPM2 NUDT22 0 0 0 256 1 1
TRPM2 IL1B 0 0 261 297 1 2
TRPM2 CXCL8 0 0 165 165 1 2
TRPM2 KCNQ1 0 0 0 202 1 1
TRPM2 MTMR6 0 0 81 174 1 1
TRPM2 STAB1 0 0 0 151 1 1
TRPM2 UNC79 0 0 0 188 1 1
TRPM2 PLD4 0 0 0 153 1 1
TRPM2 FOLR2 0 0 0 165 1 1
TRPM2 KLK3 0 0 323 323 1 1
TRPM2 KCNC1 0 0 90 212 1 1
TRPM2 TLR4 0 0 123 175 1 2
TRPM2 TRPC3 0 0 721 505 1 1
TRPM2 OLIG1 0 0 0 158 1 1
TRPM2 GABARAPL2 0 0 67 234 1 2
TRPM2 SLC18A3 0 0 0 188 1 1
TRPM2 CD14 0 0 0 177 1 1
TRPM2 NUDT17 0 0 0 301 1 1
TRPM2 ZGLP1 0 0 0 158 1 1
TRPM2 ARHGAP4 0 0 0 174 1 1
TRPM2 ITPR2 0 0 73 389 1 1
TRPM2 TPCN1 0 0 228 267 1 1
TRPM2 RYR3 0 0 104 160 1 1
TRPM2 RAPGEF4 0 0 138 152 1 1
TRPM2 AK3 0 0 0 157 1 1
TRPM2 GLOD4 0 0 0 187 1 1
TRPM2 TRPC1 0 0 723 491 1 1
TRPM2 ODF3B 0 0 0 163 1 1
TRPM2 SIRT2 0 0 170 169 1 2
TRPM2 KCNJ11 0 0 90 156 1 1
TRPM2 TDRD9 0 0 113 157 1 1
TRPM2 TPCN2 0 0 283 345 1 1
TRPM2 LMAN2 0 0 109 363 1 1
TRPM2 PLCG2 0 0 70 239 1 1
TRPM2 NUDT10 0 0 0 162 1 1
TRPM2 GLRA2 0 0 0 229 1 1
TRPM2 OSM 0 0 0 151 1 1
TRPM2 HDAC5 0 0 57 153 1 1
TRPM2 TFEC 0 0 0 156 1 1
TRPM2 KCNN3 0 0 0 155 1 1
TRPM2 FXN 0 0 0 240 1 1
TRPM2 TAX1BP1 0 0 82 305 1 2
TRPM2 MEFV 0 0 154 208 1 1
TRPM2 GNAQ 0 0 67 196 1 1
TRPM2 CD300A 0 0 0 173 1 1
TRPM2 PLCB2 0 0 0 324 1 1
TRPM2 KCNT2 0 0 142 208 1 1
TRPM2 ARL8B 0 0 108 362 1 1
TRPM2 TSPEAR 0 0 604 604 1 1
TRPM2 PLCB3 0 0 0 158 1 1
TRPM2 LILRA1 0 0 0 185 1 1
TRPM2 GGCX 0 0 0 190 1 1
TRPM2 MCOLN1 0 0 470 586 1 2
TRPM2 GATA3 0 0 0 157 1 1
TRPM2 CD300C 0 0 0 184 1 1
TRPM2 EML6 0 0 202 202 1 1
TRPM2 FGR 0 0 0 213 1 1
TRPM2 CALM3 0 0 359 408 1 1
TRPM2 LY86 0 0 0 214 1 1
TRPM2 ATP8B4 0 0 165 233 1 1
TRPM2 P2RX4 0 0 143 167 1 1
TRPM2 ACTRT1 0 0 74 234 1 1
TRPM2 BST1 0 0 151 226 1 1
TRPM2 MPPED2 0 0 0 202 1 1
TRPM2 ORAI1 0 0 520 538 1 1
TRPM2 LCP2 0 0 0 181 1 1
TRPM2 FER1L5 0 0 0 156 1 1
TRPM2 LAMP1 0 0 107 180 1 2
TRPM2 ADORA3 0 0 0 175 1 1
TRPM2 CCS 0 0 108 200 1 2
TRPM2 ASPM 0 0 0 190 1 1
TRPM2 PARVG 0 0 113 272 1 1
TRPM2 CXCL2 0 0 296 296 1 1
TRPM2 TAC1 0 0 142 162 1 1
TRPM2 DLG4 0 0 107 166 1 2
TRPM2 KCNK2 0 0 181 186 1 1
TRPM2 KCNA2 0 0 138 215 1 1
TRPM2 KCNA3 0 0 233 288 1 1
TRPM2 DRD5 0 0 0 158 1 1
TRPM2 FKBP2 0 0 330 330 1 1
TRPM2 PKD2L1 0 0 369 544 1 1
TRPM2 NUDT1 0 0 0 170 1 1
TRPM2 NUDT7 0 0 0 206 1 1
TRPM2 CDC42EP2 0 0 140 370 1 1
TRPM2 TRPV3 0 0 567 326 1 1
TRPM2 MBP 0 0 52 203 1 2
TRPM2 RCN1 0 0 0 173 1 1
TRPM2 GRM2 0 0 306 321 1 1
TRPM2 C1QA 0 0 0 238 1 1
TRPM2 SASH3 0 0 0 155 1 1
TRPM2 LAPTM5 0 0 0 183 1 1
TRPM2 PPT1 0 0 134 308 1 1
TRPM2 TLR8 0 0 0 151 1 1
TRPM2 GRIN1 0 0 0 153 1 1
TRPM2 ITGAM 0 0 46 218 1 1
TRPM2 TRPA1 0 0 505 639 1 1
TRPM2 GATA2 0 0 0 157 1 1
TRPM2 GNA11 0 0 0 174 1 1
TRPM2 DUOX2 0 0 158 165 1 1
TRPM2 CTSB 0 0 165 218 1 2
TRPM2 NOX1 0 0 195 195 1 1
TRPM2 SPI1 0 0 0 329 1 1
TRPM2 SIRT1 0 0 170 188 1 2
TRPM2 C1QC 0 0 0 217 1 1
TRPM2 PRKCA 0 0 218 236 1 1
TRPM2 WDFY4 0 0 0 286 1 1
TRPM2 CNTNAP5 0 0 322 336 1 1
TRPM2 IPO4 0 0 0 208 1 1
TRPM2 ESPN 0 0 0 187 1 1
TRPM2 NUDT18 0 0 0 234 1 1
TRPM2 KCNN4 0 0 215 303 1 1
TRPM2 S100A8 0 0 0 178 1 2
TRPM2 LMAN2L 0 0 0 208 1 1
TRPM2 MNDA 0 0 0 267 1 1
TRPM2 KCNK18 0 0 96 335 1 1
TRPM2 AIFM3 0 0 0 155 1 1
TRPM2 RNASE6 0 0 0 179 1 1
TRPM2 ARHGEF1 0 0 150 178 1 1
TRPM2 ITGB2 0 0 0 280 1 1
TRPM2 EVC2 0 0 0 155 1 1
TRPM2 VSIG4 0 0 0 213 1 1
TRPM2 GRIN2B 0 0 113 150 1 1
TRPM2 CPSF3 0 0 82 257 1 1
TRPM2 ORAI3 0 0 539 588 1 1
TRPM2 CD86 0 0 0 167 1 1
TRPM2 WAS 0 0 0 158 1 1
TRPM2 MCHR1 0 0 0 207 1 1
TRPM2 HNRNPL 270 0 0 270 1 1
TRPM2 NLRP3 0 0 287 334 1 2
TRPM2 PARG 0 0 556 559 1 1
TRPM2 CD53 0 0 0 179 1 1
TRPM2 GNA15 0 0 0 167 1 1
TRPM2 ADPRM 0 0 0 187 1 1
TRPM2 CASP3 0 0 202 202 1 2
TRPM2 RPS10-NUDT3 0 0 0 162 1 1
TRPM2 ALOX5 0 0 0 151 1 1
TRPM2 RANBP6 0 0 0 225 1 1
TRPM2 RNASE2 0 0 0 156 1 1
TRPM2 VPS13A 0 0 0 153 1 1
TRPM2 CYBB 0 0 302 405 1 2
TRPM2 TRPC4 0 0 721 491 1 1
TRPM2 KCNQ2 0 0 97 192 1 1
TRPM2 NUDT9 0 0 847 214 1 1
TRPM2 FOLH1 0 0 608 608 1 1
TRPM2 IL1RAP 0 0 71 313 1 1
TRPM2 TRPM3 0 0 661 204 1 1
TRPM2 HCK 0 0 0 169 1 1
TRPM2 AK1 0 0 0 165 1 1
TRPM2 TMEM106B 0 0 96 354 1 1
TRPM2 CPNE5 0 0 0 165 1 1
TRPM2 PIK3CD 0 0 57 168 1 1
TRPM2 TRPV5 0 0 557 664 1 1
TRPM2 JAKMIP1 0 0 0 170 1 1
TRPM2 CORO1A 0 0 0 154 1 1
TRPM2 PKD1 0 0 346 610 1 1
TRPM2 IRF8 0 0 0 181 1 1
TRPM2 ORAI2 0 0 539 588 1 1
TRPM2 VDAC3 0 0 113 187 1 1
TRPM2 SLC24A4 0 0 0 152 1 1
TRPM2 TRPV2 0 800 603 935 1 1
TRPM2 FMNL1 0 0 91 181 1 1
TRPM2 EEA1 0 0 95 187 1 2
TRPM2 MCU 0 0 136 206 1 2
TRPM2 TGOLN2 0 0 101 345 1 1
TRPM2 TRPV4 0 0 561 331 1 1
TRPM2 C1QB 0 0 0 213 1 1
TRPM2 P2RX1 0 0 81 192 1 1
TRPM2 KCNN2 0 0 75 299 1 1
TRPM2 NUDT6 0 0 0 206 1 1
TRPM2 CLEC5A 0 0 0 151 1 1
TRPM2 HMOX1 0 0 158 157 1 2
TRPM2 ZC3H13 0 0 0 155 1 1
TRPM2 CACNA1A 0 0 70 152 1 1
TRPM2 FAM115C 0 0 156 157 1 1
TRPM2 NOX4 0 0 223 223 1 2
TRPM2 NADK 0 0 151 238 1 1
TRPM2 DUOX1 0 0 170 177 1 1
TRPM2 PANX1 0 0 104 259 1 1
TRPM2 ALOX5AP 0 0 0 151 1 1
TRPM2 KCNAB2 0 0 0 267 1 1
TRPM2 VIP 0 0 0 199 1 1
TRPM2 NOSIP 0 0 0 154 1 1
TRPM2 NUDT12 0 0 60 158 1 1
TRPM2 ATP2A3 0 0 0 165 1 1
TRPM2 RRM1 0 0 292 292 1 1
TRPM2 F13A1 0 0 0 174 1 1
TRPM2 SGK3 0 0 0 163 1 1
TRPM2 DYSF 0 0 0 206 1 1
TRPM2 AKT1 0 0 167 167 1 2
TRPM2 PRR12 0 0 0 255 1 1
TRPM2 ERVV-1 0 0 181 181 1 1
TRPM2 IMMP1L 0 0 0 215 1 1
TRPM2 PKD2 0 0 414 548 1 2
TRPM2 ATP6V1A 0 0 76 323 1 1
TRPM2 PIK3R6 0 0 0 187 1 1
TRPM2 LINGO3 0 0 0 175 1 1
TRPM2 SLC24A3 0 0 123 315 1 1
TRPM2 PIKFYVE 0 0 107 285 1 2
TRPM2 HSP90AB1 0 0 0 371 1 2
TRPM2 ANK3 0 0 0 189 1 1
TRPM2 SIRT4 0 0 205 205 1 1
TRPM2 OTOF 0 0 0 183 1 1
TRPM2 MYOF 0 0 0 156 1 1
TRPM2 BTK 0 0 0 159 1 1
TRPM2 SLAMF8 0 0 0 157 1 1
TRPM2 CSF1R 0 0 0 222 1 1
TRPM2 LRRC39 0 0 90 156 1 1
TRPM2 GBP5 0 0 172 193 1 1
TRPM2 CDH5 0 0 174 173 1 1
TRPM2 MS4A14 0 0 0 213 1 1
TRPM2 SHROOM2 0 0 0 183 1 1
TRPM2 BCL2A1 0 0 0 191 1 1
TRPM2 S100A9 0 0 0 161 1 1
TRPM2 ZNF451 0 0 108 423 1 1
TRPM2 NUDT5 0 0 297 414 1 1
TRPM2 AGT 0 0 0 157 1 1
TRPM2 FUT7 0 0 0 186 1 1
TRPM2 TRPM1 0 0 727 229 1 1
TRPM2 CD300LF 0 0 0 192 1 1
TRPM2 TNNC2 0 0 94 189 1 1
TRPM2 TRAP1 0 0 0 254 1 2
TRPM2 STK32C 0 0 0 167 1 1
TRPM2 PLCB1 0 0 0 158 1 1
TRPM2 TNF 0 0 209 247 1 2
TRPM2 PTK2B 0 0 435 500 1 1
TRPM2 ANK2 0 0 0 189 1 1
TRPM2 CAT 0 0 231 230 1 2
TRPM2 LCP1 0 0 0 168 1 1
TRPM2 TXN 0 0 150 192 1 1
TRPM2 CD38 0 0 370 391 1 2
TRPM2 MYH2 0 0 0 154 1 1
TRPM2 MLC1 0 0 0 158 1 1
TRPM2 TRPS1 0 0 0 167 1 1
TRPM2 APOBR 0 0 0 166 1 1
TRPM2 KCNK9 0 0 90 227 1 1
TRPM2 PPT2 0 0 0 162 1 1
TRPM2 STIM1 0 0 535 607 1 2
TRPM2 SPTBN5 0 0 0 155 1 1
TRPM2 HK3 0 0 0 214 1 1
TRPM2 NCF1 0 0 204 245 1 1
TRPM2 DRD1 0 0 0 159 1 1
TRPM2 SGK1 0 0 0 152 1 2
TRPM2 KCNA1 0 0 108 189 1 1
TRPM2 CPLX1 0 0 74 182 1 1
TRPM2 FCGR1A 0 0 0 175 1 1
TRPM2 NUDT11 0 0 0 162 1 1
TRPM2 RPS6KB1 0 0 0 233 1 2
TRPM2 CRLF1 0 0 95 233 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0047631 Molecular Function ADP-ribose diphosphatase activity NOT enables IDA
GO:0005262 Molecular Function calcium channel activity enables TAS
GO:0005509 Molecular Function calcium ion binding enables IDA
GO:0005509 Molecular Function calcium ion binding enables IMP
GO:0015278 Molecular Function calcium-release channel activity enables IMP
GO:0016787 Molecular Function hydrolase activity NOT enables IMP
GO:0099604 Molecular Function ligand-gated calcium channel activity enables IBA
GO:0099604 Molecular Function ligand-gated calcium channel activity enables IDA
GO:0005384 Molecular Function manganese ion transmembrane transporter activity enables IEA
GO:0072571 Molecular Function mono-ADP-D-ribose binding enables IDA
GO:0005261 Molecular Function monoatomic cation channel activity enables IMP
GO:0005272 Molecular Function sodium channel activity enables IEA
GO:0098703 Biological Process calcium ion import across plasma membrane involved_in ISS
GO:0097553 Biological Process calcium ion transmembrane import into cytosol involved_in IMP
GO:0070588 Biological Process calcium ion transmembrane transport involved_in IDA
GO:0070588 Biological Process calcium ion transmembrane transport involved_in TAS
GO:0006816 Biological Process calcium ion transport involved_in TAS
GO:0035584 Biological Process calcium-mediated signaling using intracellular calcium source involved_in ISS
GO:0071277 Biological Process cellular response to calcium ion involved_in IMP
GO:0070301 Biological Process cellular response to hydrogen peroxide involved_in IDA
GO:0071415 Biological Process cellular response to purine-containing compound involved_in ISS
GO:0071502 Biological Process cellular response to temperature stimulus involved_in ISS
GO:0002407 Biological Process dendritic cell chemotaxis involved_in ISS
GO:0097028 Biological Process dendritic cell differentiation involved_in ISS
GO:0071421 Biological Process manganese ion transmembrane transport involved_in IEA
GO:0051289 Biological Process protein homotetramerization involved_in IDA
GO:0032956 Biological Process regulation of actin cytoskeleton organization involved_in IMP
GO:0051489 Biological Process regulation of filopodium assembly involved_in IMP
GO:0051209 Biological Process release of sequestered calcium ion into cytosol involved_in IBA
GO:0051209 Biological Process release of sequestered calcium ion into cytosol involved_in IMP
GO:0051209 Biological Process release of sequestered calcium ion into cytosol involved_in ISS
GO:0009408 Biological Process response to heat involved_in IEA
GO:0033194 Biological Process response to hydroperoxide involved_in IEA
GO:0014074 Biological Process response to purine-containing compound involved_in IMP
GO:0035725 Biological Process sodium ion transmembrane transport involved_in IEA
GO:0001659 Biological Process temperature homeostasis involved_in ISS
GO:0071577 Biological Process zinc ion transmembrane transport involved_in IMP
GO:0042995 Cellular Component cell projection located_in IEA
GO:0030659 Cellular Component cytoplasmic vesicle membrane located_in ISS
GO:0101003 Cellular Component ficolin-1-rich granule membrane located_in TAS
GO:0005765 Cellular Component lysosomal membrane located_in ISS
GO:0005764 Cellular Component lysosome located_in IDA
GO:0043204 Cellular Component perikaryon located_in IEA
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0005886 Cellular Component plasma membrane located_in IMP
GO:0005886 Cellular Component plasma membrane located_in ISS
GO:0005886 Cellular Component plasma membrane located_in TAS
GO:0035579 Cellular Component specific granule membrane located_in TAS
GO:0070821 Cellular Component tertiary granule membrane located_in TAS
Pathways
Name DB ID
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Stimuli-sensing channels Reactome R-HSA-2672351
TRP channels Reactome R-HSA-3295583
Transport of small molecules Reactome R-HSA-382551
Neutrophil degranulation Reactome R-HSA-6798695
Ion channel transport Reactome R-HSA-983712
Network map of SARS-CoV-2 signaling pathway (WP5115) WikiPathways WP5115_r124648
Ectoderm differentiation (WP2858) WikiPathways WP2858_r116763
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_038257 2 miscRNA transcript variant 2 NC_000021 Reference
XM_011529736 3 mRNA transcript variant X1 NC_000021 Reference
XM_017028457 3 mRNA transcript variant X2 NC_000021 Reference
NM_001320350 2 mRNA transcript variant 3 NC_000021 Reference
NM_003307 4 mRNA transcript variant 1 NC_000021 Reference
NM_001320351 2 mRNA transcript variant 4 NC_000021 Reference
XM_047440977 1 mRNA transcript variant X3 NC_000021 Reference
XM_047440978 1 mRNA transcript variant X4 NC_000021 Reference
XM_047440979 1 mRNA transcript variant X5 NC_000021 Reference
NM_001320352 3 mRNA transcript variant 5 NC_000021 Reference