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UCP1

uncoupling protein 1
General Information
Name uncoupling protein 1
Alias
  • mitochondrial brown fat uncoupling protein 1
  • solute carrier family 25 member 7
  • thermogenin
  • uncoupling protein 1 (mitochondrial, proton carrier)
Gene_family Solute carriers
organism Homo sapiens
entrez_id 7350
location 4q31.1
transcript_count 3
exon_count 7
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
    Stringdb Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in [...]
    nextProt Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
UCP1 BioGRID NME2P1 GeneID BioGRID Affinity Capture-MS
UCP1 BioGRID SREBF2 GeneID BioGRID Negative Genetic
UCP1 BioGRID GSTM1 GeneID BioGRID Affinity Capture-MS
UCP1 Protein CIDEA GeneID HPRD
UCP1 Protein TOMM20 GeneID HPRD
UCP1 BioGRID TOMM20 GeneID BioGRID Reconstituted Complex
StringDB
A B experiments database textmining combined score hadb nhadb
UCP1 IRS2 0 0 381 381 1 1
UCP1 CD8A 0 0 162 161 1 1
UCP1 SORD 0 0 103 183 1 1
UCP1 MFN1 0 0 310 309 1 2
UCP1 IGFBP3 0 0 151 150 1 2
UCP1 NAT8L 0 0 235 289 1 1
UCP1 SERTAD2 0 0 217 228 1 1
UCP1 SLC27A6 0 0 392 392 1 1
UCP1 NCOA3 0 0 151 150 1 1
UCP1 RBP4 0 0 321 336 1 1
UCP1 ATP5B 0 0 288 309 1 1
UCP1 SLC36A2 0 0 391 420 1 1
UCP1 NDUFB2 0 0 94 189 1 1
UCP1 COL3A1 0 0 105 160 1 1
UCP1 TSHB 0 0 145 165 1 1
UCP1 SLC7A10 0 0 203 203 1 1
UCP1 TFAM 0 0 631 637 1 2
UCP1 GHRH 0 0 171 171 1 1
UCP1 INSIG2 0 0 206 239 1 1
UCP1 CAPN2 0 0 294 294 1 2
UCP1 FST 0 0 202 202 1 1
UCP1 CASQ1 0 0 112 170 1 1
UCP1 AZGP1 0 0 324 323 1 1
UCP1 P2RX5 0 0 358 358 1 1
UCP1 TPH2 0 0 113 174 1 1
UCP1 PM20D1 0 0 422 435 1 1
UCP1 CITED1 0 0 502 502 1 1
UCP1 PRDX1 0 0 140 162 1 1
UCP1 ANGPTL6 0 0 155 154 1 1
UCP1 BMI1 0 0 0 199 1 1
UCP1 SOD1 0 0 234 239 1 2
UCP1 TBC1D4 0 0 260 260 1 1
UCP1 ELOVL6 0 0 392 405 1 1
UCP1 SLC16A4 0 0 141 199 1 1
UCP1 NR2F2 0 0 147 164 1 1
UCP1 NRF1 0 0 519 519 1 2
UCP1 KCNK3 0 0 314 313 1 1
UCP1 SI 0 0 193 193 1 1
UCP1 COX17 0 0 69 152 1 1
UCP1 CYP19A1 0 0 180 179 1 2
UCP1 KL 0 0 202 208 1 2
UCP1 TAZ 0 0 123 152 1 1
UCP1 PNMA3 0 0 55 150 1 1
UCP1 NPPB 0 0 261 261 1 1
UCP1 MPZL2 0 0 504 544 1 1
UCP1 FABP3 0 0 468 481 1 1
UCP1 CTDSP2 0 0 0 191 1 1
UCP1 JUN 0 0 306 306 1 2
UCP1 NPY2R 0 0 181 186 1 1
UCP1 NCOA2 0 0 195 195 1 1
UCP1 PFKP 0 0 150 220 1 1
UCP1 KLK8 0 0 52 204 1 1
UCP1 NNMT 0 0 218 218 1 1
UCP1 TEX2 0 0 56 221 1 1
UCP1 CYP7A1 0 0 341 341 1 1
UCP1 SLC25A27 0 300 710 379 1 1
UCP1 CRTC3 0 0 292 292 1 1
UCP1 SLC16A3 0 0 156 186 1 1
UCP1 MRAP2 0 0 142 181 1 1
UCP1 PER2 0 0 245 244 1 1
UCP1 FFAR2 0 0 218 218 1 1
UCP1 OTOP1 0 0 508 564 1 1
UCP1 CAV1 0 0 208 208 1 2
UCP1 SLC25A31 0 0 297 184 1 1
UCP1 SRF 0 0 107 201 1 1
UCP1 SIK2 0 0 146 153 1 1
UCP1 SERPINA12 0 0 181 197 1 1
UCP1 SLC25A44 0 0 90 201 1 1
UCP1 FOXG1 0 0 407 426 1 1
UCP1 ACTB 0 0 601 628 1 2
UCP1 INS 0 0 760 784 1 2
UCP1 GLP1R 0 0 326 326 1 1
UCP1 FGF1 0 0 205 205 1 1
UCP1 WNT6 0 0 270 270 1 1
UCP1 HOXA5 0 0 171 171 1 1
UCP1 CKMT1A 0 0 314 329 1 1
UCP1 ABCG1 0 0 162 162 1 2
UCP1 ENO3 0 0 112 151 1 1
UCP1 SIRT3 0 0 506 542 1 2
UCP1 KLF15 0 0 283 282 1 1
UCP1 MAPK3 0 0 324 338 1 2
UCP1 KEAP1 0 0 136 154 1 2
UCP1 B2M 0 0 193 208 1 1
UCP1 MMP9 0 0 141 164 1 2
UCP1 SLC16A1 0 0 208 236 1 1
UCP1 SQSTM1 0 0 144 167 1 2
UCP1 ATP5O 0 0 127 166 1 1
UCP1 PCK2 0 0 392 415 1 1
UCP1 PRLH 0 0 227 226 1 1
UCP1 PNPLA2 0 0 720 727 1 2
UCP1 HSP90AA1 0 0 204 218 1 2
UCP1 SLC51B 0 0 122 157 1 1
UCP1 CTBP1 0 0 264 270 1 1
UCP1 HADHA 0 0 261 280 1 1
UCP1 TFEB 0 0 202 202 1 2
UCP1 ACAA2 0 0 226 246 1 1
UCP1 SP7 0 0 193 193 1 1
UCP1 HDAC4 0 0 150 220 1 2
UCP1 CEBPA 0 0 681 685 1 1
UCP1 FAM132A 0 0 150 170 1 1
UCP1 COX4I1 0 0 565 574 1 1
UCP1 CRP 0 0 295 322 1 2
UCP1 ATF2 0 0 325 325 1 1
UCP1 CKM 0 0 156 174 1 1
UCP1 SLC10A2 0 0 309 309 1 1
UCP1 ESR2 0 0 210 226 1 1
UCP1 GDF3 0 0 150 195 1 1
UCP1 EHHADH 0 0 287 306 1 1
UCP1 PTPRC 0 0 224 224 1 1
UCP1 SOST 0 0 165 165 1 1
UCP1 WISP2 0 0 108 169 1 1
UCP1 ELOVL3 0 0 759 804 1 1
UCP1 SIRT7 0 0 360 407 1 2
UCP1 MPC1 0 0 120 186 1 1
UCP1 ICAM1 0 0 170 171 1 2
UCP1 ADORA2A 0 0 167 167 1 1
UCP1 SLC25A14 0 300 768 397 1 1
UCP1 NKRF 0 0 152 151 1 1
UCP1 SPP1 0 0 166 166 1 2
UCP1 PLIN5 0 0 360 374 1 1
UCP1 C2CD3 0 0 54 152 1 1
UCP1 AR 0 0 203 219 1 2
UCP1 CRTC2 0 0 195 195 1 1
UCP1 GSR 0 0 150 243 1 1
UCP1 GANC 0 0 53 221 1 1
UCP1 INSR 0 0 270 270 1 1
UCP1 KDM1A 0 0 246 247 1 2
UCP1 CARTPT 0 0 422 422 1 1
UCP1 FABP5 0 0 248 269 1 1
UCP1 TOMM40 0 0 76 367 1 1
UCP1 TGM5 0 0 61 211 1 1
UCP1 MTTP 0 0 134 157 1 1
UCP1 GABPB1 0 0 189 215 1 1
UCP1 PYY 0 0 341 355 1 1
UCP1 PLA2G16 0 0 192 192 1 1
UCP1 SIRT6 0 0 362 409 1 2
UCP1 HMGCS2 0 0 270 314 1 1
UCP1 PRKCZ 0 0 95 160 1 1
UCP1 BMP7 0 0 601 601 1 1
UCP1 RYR1 0 0 202 202 1 2
UCP1 OTUB2 0 0 0 150 1 1
UCP1 NRG4 0 0 455 466 1 1
UCP1 PDGFRA 0 0 283 282 1 1
UCP1 FNDC5 0 0 805 805 1 1
UCP1 MLXIPL 0 0 459 459 1 1
UCP1 LLGL1 0 0 155 172 1 1
UCP1 BCHE 0 0 63 157 1 1
UCP1 DPP4 0 0 261 280 1 1
UCP1 NR3C2 0 0 234 249 1 1
UCP1 ZNF395 0 0 63 152 1 1
UCP1 IAPP 0 0 245 250 1 2
UCP1 GABRB1 0 0 0 329 1 1
UCP1 ABCA1 0 0 267 267 1 2
UCP1 ATP2A1 0 0 210 253 1 1
UCP1 ACVR2B 0 0 209 209 1 1
UCP1 ACAA1 0 0 163 184 1 1
UCP1 IL1A 0 0 146 165 1 1
UCP1 ENHO 0 0 195 195 1 1
UCP1 CD68 0 0 343 343 1 2
UCP1 GADD45GIP1 0 0 181 218 1 1
UCP1 IRX1 0 0 181 186 1 1
UCP1 ALB 0 0 505 563 1 2
UCP1 CCL2 0 0 460 459 1 2
UCP1 SDHA 0 0 264 370 1 1
UCP1 KNG1 0 0 90 171 1 1
UCP1 CREB3L3 0 0 181 181 1 1
UCP1 SFRP5 0 0 227 233 1 1
UCP1 LEPR 0 0 556 566 1 1
UCP1 KAT2A 0 0 195 203 1 1
UCP1 PGK1 0 0 108 150 1 2
UCP1 ADRB3 0 0 870 877 1 1
UCP1 ITGB1 0 0 208 208 1 1
UCP1 CRABP2 0 0 134 162 1 1
UCP1 ITLN1 0 0 276 276 1 1
UCP1 AACS 0 0 134 160 1 1
UCP1 ADRA2A 0 0 162 161 1 1
UCP1 PKLR 0 0 112 154 1 1
UCP1 IL4 0 0 334 334 1 1
UCP1 WNT9B 0 0 329 329 1 1
UCP1 THADA 0 0 81 241 1 1
UCP1 CDK5 0 0 141 162 1 2
UCP1 ADIPOR1 0 0 404 404 1 1
UCP1 ACSS1 0 0 218 242 1 1
UCP1 EP300 0 0 306 313 1 2
UCP1 TECR 0 0 0 168 1 1
UCP1 CNTF 0 0 180 186 1 1
UCP1 FAM213A 0 0 160 178 1 1
UCP1 SMAD3 0 0 252 252 1 2
UCP1 CRY2 0 0 122 158 1 1
UCP1 SLC27A5 0 0 134 153 1 1
UCP1 CYCS 0 0 460 492 1 2
UCP1 IMMT 0 0 421 447 1 1
UCP1 HK1 0 0 181 200 1 1
UCP1 POMC 0 0 602 642 1 1
UCP1 GDF2 0 0 242 241 1 1
UCP1 CNOT7 0 0 122 206 1 1
UCP1 SESN3 0 0 63 207 1 1
UCP1 NDUFB9 0 0 0 202 1 1
UCP1 SLC6A8 0 0 194 209 1 1
UCP1 GPAT2 0 0 107 168 1 1
UCP1 FASN 0 0 609 629 1 2
UCP1 PCSK1 0 0 218 218 1 1
UCP1 HNF1A 0 0 245 250 1 1
UCP1 AKR1B1 0 0 167 167 1 1
UCP1 ATP5A1 0 0 142 296 1 1
UCP1 EGF 0 0 167 167 1 2
UCP1 SETD7 0 0 134 163 1 1
UCP1 BMP2 0 0 227 226 1 1
UCP1 PRKAB2 0 0 125 245 1 1
UCP1 CYP27A1 0 0 155 154 1 1
UCP1 GCGR 0 0 261 261 1 1
UCP1 PPIB 0 0 150 168 1 1
UCP1 DICER1 0 0 150 171 1 1
UCP1 LPIN3 0 0 108 178 1 1
UCP1 CKMT2 0 0 321 335 1 1
UCP1 PRM1 0 0 387 386 1 1
UCP1 HSPA4 0 0 138 155 1 1
UCP1 CFD 0 0 460 472 1 1
UCP1 CETP 0 0 181 181 1 1
UCP1 PPARA 0 0 758 768 1 2
UCP1 NAP1L5 0 0 113 186 1 1
UCP1 LPL 0 0 636 658 1 1
UCP1 NNAT 0 0 233 232 1 1
UCP1 CHAT 0 0 122 190 1 1
UCP1 CEBPD 0 0 421 427 1 1
UCP1 RPTOR 0 0 284 284 1 2
UCP1 MT-ATP6 0 0 156 155 1 1
UCP1 LHX8 0 0 469 469 1 1
UCP1 CCR2 0 0 181 181 1 2
UCP1 SESN2 0 0 142 201 1 2
UCP1 GMPR 0 0 212 212 1 1
UCP1 NDUFS7 0 0 70 258 1 1
UCP1 HIST2H3PS2 0 0 182 196 1 1
UCP1 SURF1 0 0 108 267 1 1
UCP1 VR1 0 0 395 406 1 1
UCP1 AMBN 0 0 0 201 1 1
UCP1 GPX4 0 0 82 160 1 2
UCP1 KLF5 0 0 171 171 1 2
UCP1 MEST 0 0 244 250 1 1
UCP1 CISH 0 0 112 164 1 1
UCP1 PAQR9 0 0 112 200 1 1
UCP1 CPT1B 0 0 688 706 1 1
UCP1 NR3C1 0 0 324 338 1 1
UCP1 CRHR2 0 0 147 165 1 1
UCP1 MAPK8 0 0 193 193 1 2
UCP1 ARG1 0 0 234 235 1 2
UCP1 MIPEP 0 0 123 174 1 1
UCP1 PRKAB1 0 0 138 259 1 2
UCP1 COX6A2 0 0 151 185 1 1
UCP1 MC5R 0 0 170 227 1 1
UCP1 ADIPOQ 0 0 767 821 1 2
UCP1 TRPM8 0 0 374 374 1 1
UCP1 CTDSPL 0 0 0 191 1 1
UCP1 PHOSPHO1 0 0 141 232 1 1
UCP1 CALCA 0 0 184 212 1 1
UCP1 HDAC5 0 0 107 181 1 1
UCP1 CIDEB 0 0 136 180 1 1
UCP1 SLC2A3 0 0 148 162 1 1
UCP1 SPAG5 0 0 74 216 1 1
UCP1 MTO1 0 0 0 206 1 1
UCP1 COX7A2 0 0 171 241 1 1
UCP1 TTN 0 0 57 279 1 1
UCP1 HDAC3 0 0 181 218 1 2
UCP1 PARK7 0 0 145 161 1 2
UCP1 ACSL1 0 0 393 393 1 1
UCP1 SUCNR1 0 0 96 151 1 1
UCP1 EBF2 0 0 629 641 1 1
UCP1 NDUFS3 0 0 139 158 1 1
UCP1 DUSP4 0 0 88 181 1 1
UCP1 NUPR1 0 0 431 431 1 2
UCP1 ZNF423 0 0 517 517 1 1
UCP1 CIDEA 213 0 870 911 1 1
UCP1 SLC25A19 0 0 842 335 1 1
UCP1 AKT2 0 0 321 341 1 2
UCP1 CEL 0 0 113 168 1 1
UCP1 NFE2L2 0 0 243 242 1 2
UCP1 PPIF 0 0 160 159 1 1
UCP1 TOP2A 0 0 56 375 1 1
UCP1 UBBP4 0 0 0 157 1 1
UCP1 NPY 0 0 618 641 1 1
UCP1 HNRNPU 0 0 126 180 1 1
UCP1 STK11 0 0 315 335 1 2
UCP1 PFKM 0 0 165 201 1 1
UCP1 CLOCK 0 0 156 212 1 2
UCP1 TRAPPC9 0 0 0 179 1 1
UCP1 PARK2 0 0 136 193 1 1
UCP1 PPIP5K1 0 0 164 163 1 1
UCP1 NR0B2 0 0 279 294 1 1
UCP1 ACOT11 0 0 367 390 1 1
UCP1 MAD2L1 0 0 0 288 1 1
UCP1 PAX7 0 0 401 400 1 1
UCP1 CKMT1B 0 0 325 339 1 1
UCP1 ELMOD2 0 0 293 393 1 1
UCP1 IL15 0 0 181 181 1 1
UCP1 PPRC1 0 0 183 206 1 1
UCP1 MYC 0 0 181 181 1 2
UCP1 KLB 0 0 564 589 1 1
UCP1 APEX1 0 0 75 233 1 1
UCP1 DGAT1 0 0 505 520 1 2
UCP1 TPH1 0 0 259 258 1 1
UCP1 PCK1 0 0 468 506 1 1
UCP1 PPARGC1A 0 0 873 873 1 2
UCP1 SDHC 0 0 213 372 1 1
UCP1 IGF1R 0 0 174 173 1 2
UCP1 PLTP 0 0 141 231 1 1
UCP1 DSG4 0 0 0 195 1 1
UCP1 NDUFC1 0 0 86 293 1 1
UCP1 ADORA1 0 0 173 173 1 1
UCP1 NPC1 0 0 66 267 1 2
UCP1 CTDSP1 0 0 0 191 1 1
UCP1 GPX7 0 0 46 161 1 1
UCP1 IRX5 0 0 218 223 1 1
UCP1 CYP7B1 0 0 152 151 1 1
UCP1 SLC7A1 0 0 193 193 1 1
UCP1 NOG 0 0 72 168 1 1
UCP1 RICTOR 0 0 170 169 1 2
UCP1 APPL1 0 0 141 170 1 1
UCP1 G6PC 0 0 504 504 1 1
UCP1 ACACA 0 0 504 504 1 1
UCP1 NR4A3 0 0 150 191 1 1
UCP1 MICU1 0 0 112 153 1 1
UCP1 NR2F6 0 0 240 255 1 1
UCP1 TIGD4 0 0 107 461 1 1
UCP1 NR1I3 0 0 125 174 1 1
UCP1 WNT5B 0 0 308 307 1 1
UCP1 GHRL 0 0 519 519 1 1
UCP1 JAK2 0 0 194 195 1 2
UCP1 VGF 0 0 431 439 1 1
UCP1 PPARD 0 0 389 467 1 1
UCP1 NR4A1 0 0 162 161 1 2
UCP1 BHLHE22 0 0 391 390 1 1
UCP1 CTBP2 0 0 204 204 1 1
UCP1 CAMKK2 0 0 126 186 1 2
UCP1 PMPCA 0 0 0 161 1 1
UCP1 RBP2 0 0 95 151 1 1
UCP1 MYH6 0 0 219 219 1 1
UCP1 FAM46C 0 0 0 155 1 1
UCP1 NDUFS1 0 0 134 214 1 1
UCP1 TMEM260 0 0 81 177 1 1
UCP1 C1QTNF7 0 0 124 283 1 1
UCP1 AQP7 0 0 210 228 1 1
UCP1 TCF21 0 0 324 333 1 1
UCP1 ERN1 0 0 232 231 1 2
UCP1 CPT2 0 0 518 538 1 1
UCP1 NCOA1 0 0 181 186 1 1
UCP1 VDAC2 0 0 95 189 1 1
UCP1 PLIN4 0 0 218 226 1 1
UCP1 STAT3 0 0 391 408 1 2
UCP1 EIF2AK4 0 0 244 285 1 2
UCP1 TIMM23B 0 0 60 156 1 1
UCP1 HMGCS1 0 0 142 165 1 1
UCP1 COMMD8 0 0 72 320 1 1
UCP1 INSIG1 0 0 181 195 1 1
UCP1 TAF9 0 0 0 155 1 1
UCP1 CCRN4L 0 0 168 221 1 1
UCP1 TIMM50 0 0 47 227 1 1
UCP1 MAOA 0 0 150 188 1 1
UCP1 ALOX15 0 0 96 171 1 1
UCP1 LCN2 0 0 249 248 1 1
UCP1 TP53 0 0 244 243 1 2
UCP1 ADORA3 0 0 150 241 1 1
UCP1 HTT 0 0 144 199 1 2
UCP1 OPLAH 0 0 235 235 1 1
UCP1 DECR1 0 0 166 165 1 1
UCP1 SLC2A1 0 0 426 435 1 2
UCP1 FFAR1 0 0 234 234 1 1
UCP1 HK2 0 0 261 278 1 2
UCP1 TIMM23 0 0 86 180 1 1
UCP1 RBL1 0 0 307 307 1 1
UCP1 UQCRH 0 0 109 174 1 1
UCP1 LMNA 0 0 181 186 1 2
UCP1 SLC2A2 0 0 306 317 1 1
UCP1 KIF15 0 0 0 208 1 1
UCP1 NCOR2 0 0 143 240 1 1
UCP1 SLC25A4 0 0 259 179 1 1
UCP1 HOXC9 0 0 558 565 1 1
UCP1 PNLIP 0 0 261 270 1 1
UCP1 MED13 0 0 101 162 1 1
UCP1 NPY4R 0 0 45 224 1 1
UCP1 DDIT3 0 0 216 224 1 2
UCP1 HDAC2 0 0 87 200 1 1
UCP1 NOTCH1 0 0 162 161 1 2
UCP1 FGF13 0 0 145 163 1 1
UCP1 ABCB11 0 0 140 158 1 1
UCP1 DR1 0 0 105 233 1 1
UCP1 CISD1 0 0 294 312 1 1
UCP1 MT-CO3 0 0 278 296 1 1
UCP1 CD163 0 0 135 157 1 1
UCP1 ACOT2 0 0 325 338 1 1
UCP1 POTEF 0 0 236 288 1 1
UCP1 KLF7 0 0 180 179 1 1
UCP1 ATP5D 0 0 113 184 1 1
UCP1 MTOR 0 0 370 378 1 2
UCP1 IL6 0 0 556 566 1 2
UCP1 NPAS2 0 0 107 264 1 1
UCP1 PRKG1 0 0 208 208 1 1
UCP1 PLIN1 0 0 703 713 1 1
UCP1 MPO 0 0 136 177 1 2
UCP1 UCP2 0 300 870 333 1 2
UCP1 THRA 0 0 213 255 1 1
UCP1 MYOG 0 0 374 387 1 1
UCP1 RPS6 0 0 104 168 1 2
UCP1 LGR4 0 0 94 333 1 1
UCP1 IL1B 0 0 403 403 1 2
UCP1 CFAP20 0 0 181 181 1 1
UCP1 NR1H3 0 0 334 379 1 1
UCP1 GCK 0 0 392 422 1 1
UCP1 SIRT5 0 0 374 425 1 1
UCP1 HIF1A 0 0 464 464 1 2
UCP1 EDN1 0 0 173 173 1 1
UCP1 UQCRC2 0 0 392 463 1 1
UCP1 HSPB7 0 0 212 217 1 1
UCP1 WNT7A 0 0 296 296 1 1
UCP1 CXCL8 0 0 193 193 1 2
UCP1 GABPA 0 0 151 150 1 1
UCP1 COX6B1 0 0 159 199 1 1
UCP1 MRPL12 0 0 122 180 1 1
UCP1 TRPV1 0 0 395 406 1 2
UCP1 LIPE 0 0 753 773 1 1
UCP1 EGR1 0 0 181 181 1 2
UCP1 DCAF6 0 0 74 217 1 1
UCP1 APP 0 0 113 174 1 2
UCP1 MFN2 0 0 392 392 1 2
UCP1 MYF5 0 0 681 688 1 1
UCP1 CTNNB1 0 0 218 226 1 2
UCP1 UQCRB 0 0 74 287 1 1
UCP1 ACSL5 0 0 269 269 1 1
UCP1 PRKAG1 0 0 94 228 1 1
UCP1 LIAS 0 0 63 485 1 1
UCP1 PRKAR2B 0 0 181 201 1 1
UCP1 ARFIP1 0 0 50 417 1 1
UCP1 SLC5A7 0 0 49 306 1 1
UCP1 WNT2B 0 0 306 306 1 1
UCP1 PSAT1 0 0 170 194 1 1
UCP1 ACSL3 0 0 171 189 1 1
UCP1 SLC25A20 0 0 371 191 1 1
UCP1 ZIC1 0 0 561 561 1 1
UCP1 TFB1M 0 0 174 192 1 1
UCP1 ADCYAP1 0 0 113 153 1 1
UCP1 MMP20 0 0 0 631 1 1
UCP1 ME1 0 0 150 190 1 1
UCP1 ACSS2 0 0 207 231 1 1
UCP1 COX5B 0 0 391 406 1 1
UCP1 EMCN 0 0 160 308 1 1
UCP1 NPR1 0 0 340 340 1 1
UCP1 KLK15 0 0 218 218 1 1
UCP1 SLC5A4 0 0 143 166 1 1
UCP1 METRNL 0 0 456 456 1 1
UCP1 GAPDH 0 0 519 532 1 2
UCP1 TNFRSF25 0 0 46 192 1 1
UCP1 FGFR2 0 0 74 152 1 1
UCP1 SMAD2 0 0 181 181 1 2
UCP1 EMR1 0 0 235 295 1 1
UCP1 TLR4 0 0 269 269 1 2
UCP1 NOS2 0 0 167 256 1 2
UCP1 EBF1 0 0 210 210 1 1
UCP1 SLC18A3 0 0 66 210 1 1
UCP1 APOA1 0 0 269 285 1 1
UCP1 TCF7L2 0 0 154 153 1 1
UCP1 PFKL 0 0 113 151 1 1
UCP1 CTDSPL2 0 0 0 191 1 1
UCP1 FIG4 0 0 0 435 1 1
UCP1 MBOAT4 0 0 143 162 1 1
UCP1 RYR2 0 0 171 171 1 1
UCP1 TNP1 0 0 294 294 1 1
UCP1 RUNX1T1 0 0 124 155 1 1
UCP1 ACO2 0 0 229 336 1 1
UCP1 ESRRA 0 0 556 565 1 1
UCP1 LONP1 0 0 136 177 1 1
UCP1 TMEM26 0 0 801 831 1 1
UCP1 SDHB 0 0 285 341 1 1
UCP1 TENC1 0 0 325 336 1 1
UCP1 G0S2 0 0 167 167 1 1
UCP1 NDN 0 0 240 239 1 1
UCP1 CREB1 0 0 556 563 1 2
UCP1 CIDEC 0 0 504 534 1 1
UCP1 CCL5 0 0 150 173 1 2
UCP1 SLC25A10 0 0 268 157 1 1
UCP1 HSD11B1 0 0 340 341 1 1
UCP1 TOP3B 0 0 0 206 1 1
UCP1 BCKDHB 0 0 96 171 1 1
UCP1 COX5A 0 0 242 249 1 1
UCP1 APOA4 0 0 182 199 1 1
UCP1 HSPD1 0 0 350 361 1 1
UCP1 FBXO32 0 0 260 260 1 2
UCP1 TAGLN 0 0 158 157 1 1
UCP1 SLC25A6 0 0 255 173 1 1
UCP1 FTO 0 0 391 390 1 2
UCP1 FGF21 0 0 801 801 1 2
UCP1 C2orf49 0 0 112 152 1 1
UCP1 NPPA 0 0 245 262 1 1
UCP1 CRLS1 0 0 181 256 1 1
UCP1 CS 0 0 408 449 1 1
UCP1 WNT8A 0 0 357 357 1 1
UCP1 METRN 0 0 504 516 1 1
UCP1 ATF5 0 0 143 172 1 1
UCP1 PRDX5 0 0 145 195 1 1
UCP1 SIRT2 0 0 375 421 1 2
UCP1 KLF3 0 0 162 161 1 1
UCP1 GSDMA 0 0 0 195 1 1
UCP1 MTUS1 0 0 218 218 1 1
UCP1 HSPA5 0 0 162 178 1 2
UCP1 TOP2B 0 0 0 194 1 1
UCP1 APOO 0 0 109 230 1 1
UCP1 ZC3H10 0 0 208 236 1 1
UCP1 GPBAR1 0 0 492 491 1 1
UCP1 MECR 0 0 184 219 1 1
UCP1 PTH 0 0 193 193 1 1
UCP1 GNB3 0 0 208 208 1 1
UCP1 HOXC8 0 0 426 431 1 1
UCP1 SOD2 0 0 419 467 1 2
UCP1 FOXO1 0 0 470 495 1 2
UCP1 SH2B1 0 0 260 275 1 1
UCP1 SYNPO2 0 0 46 437 1 1
UCP1 SOCS3 0 0 294 335 1 1
UCP1 TWIST1 0 0 218 218 1 1
UCP1 KDM6B 0 0 171 204 1 1
UCP1 FOS 0 0 335 350 1 2
UCP1 THRB 0 0 303 323 1 1
UCP1 GHSR 0 0 324 323 1 1
UCP1 AGPAT6 0 0 151 184 1 1
UCP1 MSTN 0 0 456 456 1 1
UCP1 RXRA 0 0 178 245 1 1
UCP1 STAT5A 0 0 166 165 1 1
UCP1 PON1 0 0 181 181 1 1
UCP1 ANGPTL4 0 0 380 407 1 1
UCP1 MCHR1 0 0 184 194 1 1
UCP1 SCD5 0 0 193 211 1 1
UCP1 ACADVL 0 0 392 417 1 1
UCP1 MED1 0 0 253 259 1 1
UCP1 LPIN1 0 0 391 390 1 2
UCP1 RNF20 0 0 49 154 1 1
UCP1 MYH11 0 0 266 267 1 1
UCP1 CTDNEP1 0 0 0 191 1 1
UCP1 COX4I2 0 0 502 512 1 1
UCP1 IRX3 0 0 261 266 1 1
UCP1 ALDH1A1 0 0 202 202 1 1
UCP1 SERPINA7 0 0 134 223 1 1
UCP1 OLR1 0 0 122 182 1 2
UCP1 ASH2L 0 0 0 159 1 1
UCP1 SLC35G4P 0 0 141 151 1 1
UCP1 BECN1 0 0 150 165 1 2
UCP1 PHB 0 0 206 245 1 1
UCP1 PTGER3 0 0 141 175 1 1
UCP1 ACADL 0 0 458 468 1 1
UCP1 FGF23 0 0 176 227 1 1
UCP1 ATG12 0 0 150 203 1 2
UCP1 REN 0 0 298 322 1 1
UCP1 COG7 0 0 0 189 1 1
UCP1 IL13 0 0 269 269 1 2
UCP1 ACE 0 0 233 234 1 1
UCP1 PPIA 0 0 310 313 1 1
UCP1 CYBB 0 0 181 181 1 2
UCP1 PPME1 0 0 53 210 1 1
UCP1 COX6A1 0 0 150 184 1 1
UCP1 FAM46B 0 0 0 155 1 1
UCP1 NLRP3 0 0 178 177 1 2
UCP1 AGPAT9 0 0 244 273 1 1
UCP1 BRCA2 0 0 0 154 1 1
UCP1 ACSM3 0 0 162 188 1 1
UCP1 IL33 0 0 323 323 1 2
UCP1 SLCO6A1 0 0 57 156 1 1
UCP1 ESRRG 0 0 366 379 1 1
UCP1 PLIN3 0 0 181 181 1 1
UCP1 PANK3 0 0 194 236 1 1
UCP1 HCRT 0 0 466 499 1 1
UCP1 PTGS2 0 0 285 284 1 2
UCP1 FGF19 0 0 233 261 1 1
UCP1 NQO1 0 0 135 158 1 2
UCP1 MT-ND2 0 0 125 185 1 1
UCP1 CASP3 0 0 206 206 1 2
UCP1 MYH7 0 0 107 162 1 1
UCP1 ENPP1 0 0 138 164 1 1
UCP1 TBC1D9 0 0 283 357 1 1
UCP1 ZNF516 0 0 209 293 1 1
UCP1 LIPC 0 0 228 227 1 1
UCP1 HADH 0 0 241 240 1 1
UCP1 CCKAR 0 0 161 175 1 1
UCP1 TXNRD1 0 0 95 220 1 1
UCP1 LAMB4 0 0 81 244 1 1
UCP1 CEBPB 0 0 637 641 1 2
UCP1 MT-CO2 0 0 383 416 1 1
UCP1 ACOT1 0 0 180 196 1 1
UCP1 GHR 0 0 171 203 1 1
UCP1 FBP1 0 0 103 159 1 1
UCP1 TBX15 0 0 324 399 1 1
UCP1 TSPO 0 0 145 164 1 1
UCP1 ACO1 0 0 58 189 1 1
UCP1 HDAC1 0 0 150 255 1 2
UCP1 TFB2M 0 0 227 243 1 1
UCP1 ADIG 0 0 281 322 1 1
UCP1 LAMTOR1 0 0 47 165 1 1
UCP1 AHSG 0 0 150 168 1 1
UCP1 TOMM22 0 0 0 316 1 1
UCP1 TXNRD2 0 0 213 299 1 1
UCP1 RNF150 0 0 54 467 1 1
UCP1 MPC2 0 0 139 192 1 1
UCP1 GPX8 0 0 75 187 1 1
UCP1 ITGAX 0 0 269 269 1 1
UCP1 EPSTI1 0 0 283 283 1 1
UCP1 MYH1 0 0 146 204 1 1
UCP1 GSK3B 0 0 122 182 1 2
UCP1 MRC1 0 0 321 321 1 1
UCP1 SIK1 0 0 150 168 1 1
UCP1 SST 0 0 143 164 1 1
UCP1 SOCS2 0 0 90 202 1 1
UCP1 GK 0 0 368 390 1 1
UCP1 FABP4 0 0 714 732 1 1
UCP1 ADM 0 0 151 150 1 2
UCP1 ANGPTL3 0 0 164 163 1 1
UCP1 KLF2 0 0 204 204 1 1
UCP1 PDE3B 0 0 304 304 1 1
UCP1 PNPLA3 0 0 203 217 1 1
UCP1 AGPAT2 0 0 320 334 1 1
UCP1 AGRP 0 0 657 659 1 1
UCP1 ENG 0 0 136 175 1 2
UCP1 GOT2 0 0 391 413 1 1
UCP1 RET 0 0 125 187 1 1
UCP1 G6PD 0 0 195 213 1 1
UCP1 PRKAG3 0 0 0 153 1 1
UCP1 SSX2IP 0 0 155 154 1 1
UCP1 IGF2 0 0 209 209 1 1
UCP1 IDH2 0 0 73 165 1 1
UCP1 TRIM63 0 0 211 211 1 1
UCP1 NAMPT 0 0 394 416 1 2
UCP1 PPARGC1B 0 0 468 550 1 1
UCP1 COL1A1 0 0 156 155 1 2
UCP1 SMIM14 0 0 81 177 1 1
UCP1 MT-ND4 0 0 95 157 1 1
UCP1 FGFR4 0 0 210 276 1 1
UCP1 DBH 0 0 306 353 1 1
UCP1 CPT1C 0 0 653 654 1 1
UCP1 IL10 0 0 321 321 1 2
UCP1 HCAR1 0 0 155 154 1 1
UCP1 GDF15 0 0 181 181 1 1
UCP1 PREX1 0 0 67 213 1 1
UCP1 NR1H4 0 0 415 427 1 1
UCP1 ACTG1 0 0 233 242 1 1
UCP1 RXRG 0 0 113 162 1 1
UCP1 ATG7 0 0 294 309 1 2
UCP1 GDF5 0 0 150 186 1 1
UCP1 WNT10A 0 0 324 323 1 1
UCP1 PRKAA2 0 0 167 223 1 2
UCP1 FFAR4 0 0 391 390 1 1
UCP1 DNM1L 0 0 239 238 1 2
UCP1 GAPDHS 0 0 0 191 1 1
UCP1 MYOD1 0 0 392 405 1 1
UCP1 BMPR1A 0 0 203 203 1 1
UCP1 PAN3 0 0 0 246 1 1
UCP1 MAEA 0 0 63 160 1 1
UCP1 PTEN 0 0 223 236 1 2
UCP1 NCOA6 0 0 117 268 1 1
UCP1 RPS29 0 0 112 197 1 1
UCP1 AMPD2 0 0 0 172 1 1
UCP1 TRPV3 0 0 155 154 1 1
UCP1 VEGFA 0 0 325 339 1 2
UCP1 IRF4 0 0 235 367 1 1
UCP1 ACSL4 0 0 218 235 1 1
UCP1 SLC2A14 0 0 167 180 1 1
UCP1 TXN2 0 0 120 210 1 1
UCP1 NPY1R 0 0 218 458 1 1
UCP1 GPD2 0 0 261 279 1 1
UCP1 SREBF1 0 0 636 647 1 1
UCP1 SLC27A2 0 0 348 347 1 1
UCP1 NDUFA9 0 0 216 273 1 1
UCP1 TNFRSF9 0 0 600 620 1 1
UCP1 MAPK14 0 0 226 290 1 2
UCP1 LMNB2 0 0 44 190 1 1
UCP1 NFKBIA 0 0 155 154 1 2
UCP1 COMMD3-BMI1 0 0 0 199 1 1
UCP1 LEP 0 0 806 832 1 1
UCP1 BMP4 0 0 337 337 1 1
UCP1 COX8A 0 0 259 291 1 1
UCP1 WT1 0 0 168 168 1 1
UCP1 EHMT1 0 0 391 401 1 1
UCP1 ESR1 0 0 358 371 1 2
UCP1 MAP3K5 0 0 125 187 1 1
UCP1 TRPA1 0 0 240 239 1 1
UCP1 ITGAM 0 0 227 226 1 1
UCP1 PDK4 0 0 530 545 1 1
UCP1 DDIT4L 0 0 46 403 1 1
UCP1 TLE3 0 0 395 394 1 1
UCP1 DLK1 0 0 415 414 1 1
UCP1 SIRT1 0 0 614 646 1 2
UCP1 PLIN2 0 0 371 385 1 2
UCP1 ACOX1 0 0 560 568 1 1
UCP1 PRL 0 0 294 294 1 1
UCP1 ACADS 0 0 383 395 1 1
UCP1 PTPN1 0 0 324 323 1 1
UCP1 SLC22A5 0 0 107 162 1 1
UCP1 PANK1 0 0 150 191 1 1
UCP1 ELN 0 0 95 299 1 1
UCP1 COX7A1 0 0 710 765 1 1
UCP1 APOA5 0 0 180 179 1 1
UCP1 PRKAG2 0 0 62 172 1 1
UCP1 OCIAD2 0 0 60 470 1 1
UCP1 FAM46D 0 0 0 155 1 1
UCP1 XBP1 0 0 223 223 1 2
UCP1 NDUFA2 0 0 72 274 1 1
UCP1 CRH 0 0 343 366 1 1
UCP1 EXOSC5 0 0 0 207 1 1
UCP1 LRPPRC 0 0 150 188 1 2
UCP1 MAP2K6 0 0 134 189 1 1
UCP1 KLF11 0 0 247 264 1 1
UCP1 ATG5 0 0 202 282 1 2
UCP1 MT-ND1 0 0 184 189 1 1
UCP1 UBC 0 0 57 172 1 2
UCP1 HHAT 0 0 0 264 1 1
UCP1 DFFB 0 0 351 351 1 1
UCP1 NDUFB8 0 0 335 363 1 1
UCP1 MGLL 0 0 405 422 1 1
UCP1 ADRB1 0 0 460 481 1 1
UCP1 COX7A2L 0 0 170 169 1 1
UCP1 PRRG2 0 0 66 193 1 1
UCP1 HADHB 0 0 247 266 1 1
UCP1 NPC1L1 0 0 134 224 1 1
UCP1 PMPCB 0 0 0 183 1 1
UCP1 NDUFA8 0 0 53 188 1 1
UCP1 MT-CO1 0 0 340 391 1 1
UCP1 TBP 0 0 336 349 1 1
UCP1 MT-CYB 0 0 241 247 1 1
UCP1 FN1 0 0 218 218 1 2
UCP1 FBXO31 0 0 210 210 1 1
UCP1 GPX1 0 0 255 278 1 1
UCP1 RARS 0 0 181 181 1 1
UCP1 ULK1 0 0 166 165 1 2
UCP1 GALP 0 0 125 217 1 1
UCP1 SOD3 0 0 146 184 1 1
UCP1 ATP5G1 0 0 140 157 1 1
UCP1 NPR3 0 0 322 321 1 1
UCP1 THRSP 0 0 266 339 1 1
UCP1 FGF2 0 0 230 229 1 2
UCP1 SFRP4 0 0 53 198 1 1
UCP1 PRLR 0 0 263 341 1 1
UCP1 TXNIP 0 0 150 188 1 2
UCP1 DGUOK 0 0 0 154 1 1
UCP1 ADM2 0 0 166 171 1 1
UCP1 BCL2A1 0 0 195 233 1 1
UCP1 AGT 0 0 343 348 1 1
UCP1 VWF 0 0 92 339 1 1
UCP1 IL5 0 0 179 179 1 1
UCP1 GCG 0 0 556 556 1 1
UCP1 IREB2 0 0 0 174 1 1
UCP1 SLC3A1 0 0 142 160 1 1
UCP1 APOC3 0 0 212 212 1 1
UCP1 SHOX2 0 0 310 309 1 1
UCP1 APOB 0 0 286 298 1 2
UCP1 IGF1 0 0 459 463 1 2
UCP1 NDUFV1 0 0 143 181 1 1
UCP1 FABP1 0 0 182 202 1 1
UCP1 ARNTL 0 0 324 323 1 1
UCP1 TECRL 0 0 0 168 1 1
UCP1 CNR1 0 0 323 323 1 1
UCP1 FFAR3 0 0 167 167 1 1
UCP1 PKM 0 0 164 184 1 1
UCP1 ESRRB 0 0 150 196 1 1
UCP1 RETN 0 0 603 625 1 1
UCP1 BDNF 0 0 341 348 1 2
UCP1 CHRNA1 0 0 57 167 1 1
UCP1 MEF2C 0 0 145 163 1 1
UCP1 MMP25 0 0 0 208 1 1
UCP1 MC3R 0 0 454 454 1 1
UCP1 PDLIM5 0 0 0 214 1 1
UCP1 TSHR 0 0 189 205 1 1
UCP1 IP6K1 0 0 193 211 1 1
UCP1 ABHD5 0 0 414 418 1 1
UCP1 UCP3 0 300 876 341 1 1
UCP1 VDR 0 0 240 255 1 2
UCP1 KDM3A 0 0 622 622 1 1
UCP1 HTR2C 0 0 136 195 1 1
UCP1 TNF 0 0 497 507 1 2
UCP1 DCK 0 0 0 154 1 1
UCP1 MYF6 0 0 142 201 1 1
UCP1 UQCRC1 0 0 261 370 1 1
UCP1 MRPL15 0 0 0 204 1 1
UCP1 C19orf80 0 0 298 298 1 1
UCP1 ENAM 0 0 0 236 1 1
UCP1 PAH 0 0 49 150 1 1
UCP1 PAX3 0 0 193 208 1 1
UCP1 RPLP0 0 0 210 430 1 1
UCP1 MLYCD 0 0 231 230 1 1
UCP1 SLC16A2 0 0 134 192 1 1
UCP1 VCL 0 0 156 155 1 1
UCP1 CES1 0 0 125 163 1 1
UCP1 FIS1 0 0 252 269 1 2
UCP1 ACADM 0 0 504 513 1 1
UCP1 HCRTR1 0 0 181 181 1 1
UCP1 BRE 0 0 90 189 1 1
UCP1 IDH3A 0 0 212 231 1 1
UCP1 MRPL28 0 0 125 199 1 1
UCP1 ALDH7A1 0 0 161 161 1 1
UCP1 CLEC10A 0 0 266 266 1 1
UCP1 NRIP1 0 0 611 611 1 1
UCP1 HPRT1 0 0 284 349 1 1
UCP1 BCAT2 0 0 157 195 1 1
UCP1 NR1D1 0 0 325 325 1 2
UCP1 GPAM 0 0 261 261 1 1
UCP1 LDLR 0 0 299 299 1 2
UCP1 DFFA 0 0 460 480 1 1
UCP1 ACOT13 0 0 161 177 1 1
UCP1 ATP2A2 0 0 102 175 1 1
UCP1 SLC27A1 0 0 509 513 1 1
UCP1 UBB 0 0 57 172 1 1
UCP1 PECAM1 0 0 294 294 1 1
UCP1 CAT 0 0 390 404 1 2
UCP1 WNT10B 0 0 296 296 1 1
UCP1 TK2 0 0 0 154 1 1
UCP1 GIP 0 0 205 205 1 1
UCP1 CYC1 0 0 217 389 1 1
UCP1 PTGDS 0 0 181 214 1 1
UCP1 TBX1 0 0 628 649 1 1
UCP1 NDUFA10 0 0 57 168 1 1
UCP1 MECOM 0 0 242 247 1 1
UCP1 TXN 0 0 181 198 1 1
UCP1 TIMM17B 0 0 57 154 1 1
UCP1 CCNE1 0 0 49 240 1 1
UCP1 NDUFB5 0 0 180 234 1 1
UCP1 CAST 0 0 307 307 1 2
UCP1 FADS2 0 0 150 166 1 1
UCP1 SLC25A53 0 0 156 156 1 1
UCP1 BMP5 0 0 263 263 1 1
UCP1 ENSG00000264813 0 0 229 230 1 1
UCP1 PFDN1 0 0 0 157 1 1
UCP1 HMGCR 0 0 233 234 1 1
UCP1 FAM46A 0 0 0 155 1 1
UCP1 LOX 0 0 321 321 1 2
UCP1 IRS1 0 0 505 516 1 2
UCP1 LHB 0 0 325 325 1 1
UCP1 SGK1 0 0 146 222 1 2
UCP1 HSPA9 0 0 123 159 1 1
UCP1 AGTR1 0 0 184 183 1 1
UCP1 KAT2B 0 0 188 196 1 1
UCP1 ADRB2 0 0 457 467 1 1
UCP1 RPS6KB1 0 0 322 336 1 2
UCP1 PGC 0 0 218 235 1 1
UCP1 GAMT 0 0 167 197 1 1
UCP1 SERPINE1 0 0 335 344 1 1
UCP1 NCOR1 0 0 284 334 1 1
UCP1 SREBF2 62 0 296 316 1 1
UCP1 INS-IGF2 0 0 0 432 1 1
UCP1 PRKAA1 0 0 231 328 1 2
UCP1 DPYD 0 0 53 192 1 1
UCP1 PC 0 0 202 225 1 1
UCP1 CD36 0 0 321 335 1 2
UCP1 NOS3 0 0 370 383 1 2
UCP1 NR5A1 0 0 293 331 1 1
UCP1 TRH 0 0 414 429 1 1
UCP1 FOXC2 0 0 517 521 1 1
UCP1 ATP5F1 0 0 46 333 1 1
UCP1 WNT8B 0 0 350 349 1 1
UCP1 RCC2 0 0 0 183 1 1
UCP1 SCD 0 0 556 566 1 1
UCP1 CRAT 0 0 184 231 1 1
UCP1 SRC 0 0 166 165 1 2
UCP1 MKL1 0 0 195 195 1 1
UCP1 TIMM44 0 0 156 170 1 1
UCP1 RAG1 0 0 0 226 1 1
UCP1 TNFSF11 0 0 144 162 1 2
UCP1 SPTAN1 0 0 306 327 1 1
UCP1 BGLAP 0 0 235 235 1 1
UCP1 DGAT2 0 0 456 456 1 1
UCP1 MCU 0 0 233 255 1 2
UCP1 CRY1 0 0 202 256 1 1
UCP1 MB 0 0 193 282 1 2
UCP1 FOXO3 0 0 261 271 1 2
UCP1 SLC2A4 0 0 686 706 1 1
UCP1 KDM6A 0 0 150 184 1 1
UCP1 OXT 0 0 234 234 1 1
UCP1 VDAC3 0 0 119 167 1 1
UCP1 ETFDH 0 0 90 509 1 1
UCP1 TRPV2 0 0 184 183 1 1
UCP1 APOE 0 0 340 340 1 2
UCP1 HNF4A 0 0 233 232 1 1
UCP1 PDE1B 0 0 141 185 1 1
UCP1 EIF2AK3 0 0 211 211 1 2
UCP1 KLHL13 0 0 262 262 1 1
UCP1 TOMM40L 0 0 0 343 1 1
UCP1 STAT6 0 0 181 186 1 1
UCP1 ACLY 0 0 378 406 1 1
UCP1 LGALS3 0 0 181 181 1 2
UCP1 SLC25A5 0 0 505 256 1 1
UCP1 HRH1 0 0 162 161 1 1
UCP1 ECH1 0 0 213 222 1 1
UCP1 COASY 0 0 210 239 1 1
UCP1 SIM1 0 0 310 309 1 1
UCP1 AGTR2 0 0 160 159 1 1
UCP1 TOMM20 270 0 693 769 1 2
UCP1 RARRES2 0 0 310 309 1 1
UCP1 MMP12 0 0 74 222 1 1
UCP1 EIF2S1 0 0 172 171 1 2
UCP1 SLC6A2 0 0 140 158 1 1
UCP1 APOC2 0 0 171 189 1 1
UCP1 TRIM14 0 0 154 162 1 1
UCP1 HMOX1 0 0 288 288 1 2
UCP1 ADIPOR2 0 0 391 390 1 1
UCP1 PRDM2 0 0 505 536 1 1
UCP1 POLRMT 0 0 123 161 1 1
UCP1 RB1 0 0 155 162 1 2
UCP1 TRPV4 0 0 281 281 1 1
UCP1 IRX6 0 0 247 252 1 1
UCP1 DIO2 0 0 842 852 1 1
UCP1 GTF2B 0 0 210 252 1 1
UCP1 KIAA0922 0 0 90 487 1 1
UCP1 SCGB1A1 0 0 0 328 1 1
UCP1 VDAC1 0 0 393 413 1 2
UCP1 MC4R 0 0 602 626 1 1
UCP1 ATP5C1 0 0 124 199 1 1
UCP1 RBP1 0 0 113 153 1 1
UCP1 UCN 0 0 123 154 1 1
UCP1 CYP8B1 0 0 218 218 1 1
UCP1 PTHLH 0 0 240 239 1 1
UCP1 ACOX2 0 0 155 171 1 1
UCP1 PRDM16 0 0 872 880 1 1
UCP1 VCAM1 0 0 202 202 1 1
UCP1 UQCRFS1 0 0 102 268 1 1
UCP1 ATF4 0 0 293 297 1 2
UCP1 CD4 0 0 171 171 1 2
UCP1 WDTC1 0 0 46 194 1 1
UCP1 PPARG 0 0 830 864 1 2
UCP1 AAMP 0 0 0 173 1 1
UCP1 APLN 0 0 276 276 1 1
UCP1 PRDM4 0 0 253 275 1 1
UCP1 AKT1 0 0 519 544 1 2
UCP1 CTDP1 0 0 0 191 1 1
UCP1 CPT1A 0 0 556 570 1 1
UCP1 NDUFA5 0 0 54 164 1 1
UCP1 CLPP 0 0 134 186 1 1
UCP1 UBLCP1 0 0 0 191 1 1
UCP1 SDHD 0 0 88 156 1 1
UCP1 AMPD3 0 0 61 244 1 1
UCP1 NOX4 0 0 195 195 1 2
UCP1 SLN 0 0 468 468 1 1
UCP1 FABP2 0 0 243 248 1 1
UCP1 PHOSPHO2 0 0 109 201 1 1
UCP1 RUNX2 0 0 204 204 1 2
UCP1 KMT2D 0 0 123 152 1 1
UCP1 CEBPG 0 0 68 289 1 1
UCP1 ABHD15 0 0 81 177 1 1
UCP1 NTRK2 0 0 210 210 1 1
UCP1 ACACB 0 0 341 341 1 1
UCP1 FGFR1 0 0 242 306 1 1
UCP1 SLC2A5 0 0 150 187 1 1
UCP1 IKBKB 0 0 195 195 1 2
UCP1 LETM1 0 0 209 237 1 1
UCP1 GSTM1 275 0 48 296 1 1
UCP1 COL1A2 0 0 85 156 1 1
UCP1 ATF6 0 0 167 167 1 2
UCP1 ACE2 0 0 131 169 1 2
UCP1 GDF7 0 0 328 328 1 1
UCP1 ASPG 0 0 112 191 1 1
UCP1 DLD 0 0 81 228 1 2
UCP1 GATM 0 0 212 212 1 1
UCP1 TIMM13 0 0 92 164 1 1
UCP1 BSCL2 0 0 218 235 1 1
UCP1 TRMU 0 0 0 200 1 1
UCP1 EIF4EBP1 0 0 203 217 1 2
UCP1 PDE5A 0 0 156 156 1 1
UCP1 GPT 0 0 324 332 1 1
UCP1 BMP8B 0 0 595 603 1 1
UCP1 ADH4 0 0 0 254 1 1
UCP1 NDUFB3 0 0 71 167 1 1
UCP1 SIRT4 0 0 358 405 1 1
UCP1 CCK 0 0 294 314 1 1
UCP1 MYH4 0 0 128 188 1 1
UCP1 PINK1 0 0 214 271 1 2
UCP1 PNOC 0 0 96 294 1 1
UCP1 DHODH 0 0 45 178 1 1
UCP1 PRDX3 0 0 162 183 1 1
UCP1 NGF 0 0 202 202 1 2
UCP1 GYS2 0 0 247 264 1 1
UCP1 CD34 0 0 265 265 1 2
UCP1 VEGFB 0 0 175 194 1 1
UCP1 TH 0 0 510 510 1 2
UCP1 ARFIP2 0 0 0 248 1 1
UCP1 AIFM1 0 0 0 173 1 1
UCP1 GPRC6A 0 0 195 195 1 1
UCP1 MGAM 0 0 181 181 1 1
UCP1 LTB4R 0 0 306 306 1 1
UCP1 NR1I2 0 0 141 173 1 1
UCP1 FBN1 0 0 113 203 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0019003 Molecular Function GDP binding enables IEA
GO:0005525 Molecular Function GTP binding enables IEA
GO:1901612 Molecular Function cardiolipin binding enables ISS
GO:0036041 Molecular Function long-chain fatty acid binding enables IDA
GO:0036041 Molecular Function long-chain fatty acid binding enables ISS
GO:0017077 Molecular Function oxidative phosphorylation uncoupler activity enables IBA
GO:0017077 Molecular Function oxidative phosphorylation uncoupler activity enables ISS
GO:0015078 Molecular Function proton transmembrane transporter activity enables IDA
GO:0032555 Molecular Function purine ribonucleotide binding enables ISS
GO:0022857 Molecular Function transmembrane transporter activity enables IDA
GO:1990845 Biological Process adaptive thermogenesis involved_in IBA
GO:1990845 Biological Process adaptive thermogenesis involved_in ISS
GO:0050873 Biological Process brown fat cell differentiation involved_in ISS
GO:0070417 Biological Process cellular response to cold involved_in IEA
GO:1903495 Biological Process cellular response to dehydroepiandrosterone involved_in IEA
GO:0071398 Biological Process cellular response to fatty acid involved_in ISS
GO:0032870 Biological Process cellular response to hormone stimulus involved_in ISS
GO:0034614 Biological Process cellular response to reactive oxygen species involved_in ISS
GO:0002024 Biological Process diet induced thermogenesis involved_in IEA
GO:1990542 Biological Process mitochondrial transmembrane transport involved_in IBA
GO:1990542 Biological Process mitochondrial transmembrane transport involved_in ISS
GO:0006839 Biological Process mitochondrial transport involved_in IEA
GO:0120162 Biological Process positive regulation of cold-induced thermogenesis involved_in ISS
GO:1902600 Biological Process proton transmembrane transport involved_in IDA
GO:1903426 Biological Process regulation of reactive oxygen species biosynthetic process involved_in ISS
GO:0006357 Biological Process regulation of transcription by RNA polymerase II involved_in IEA
GO:0009409 Biological Process response to cold involved_in IBA
GO:0031667 Biological Process response to nutrient levels involved_in ISS
GO:0009266 Biological Process response to temperature stimulus involved_in ISS
GO:0005743 Cellular Component mitochondrial inner membrane located_in ISS
GO:0005743 Cellular Component mitochondrial inner membrane located_in TAS
GO:0005739 Cellular Component mitochondrion located_in IDA
Pathways
Name DB ID
The citric acid (TCA) cycle and respiratory electron transport Reactome R-HSA-1428517
Metabolism Reactome R-HSA-1430728
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Reactome R-HSA-163200
Mitochondrial Uncoupling Reactome R-HSA-166187
The fatty acid cycling model Reactome R-HSA-167826
The proton buffering model Reactome R-HSA-167827
FTO obesity variant mechanism (WP3407) WikiPathways WP3407_r123389
Thermogenesis (WP4321) WikiPathways WP4321_r123362
Thyroid hormones production and peripheral downstream signaling effects (WP4746) WikiPathways WP4746_r123317
Adipogenesis (WP236) WikiPathways WP236_r105873
Electron transport chain: OXPHOS system in mitochondria (WP111) WikiPathways WP111_r117097
Galanin receptor pathway (WP4970) WikiPathways WP4970_r113773
PPAR signaling pathway (WP3942) WikiPathways WP3942_r106517
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_005263206 4 mRNA transcript variant X1 NC_000004 Reference
NM_021833 5 mRNA None NC_000004 Reference
XM_011532228 3 mRNA transcript variant X2 NC_000004 Reference