UCP2

uncoupling protein 2

General Information

Name	uncoupling protein 2
Alias	dicarboxylate carrier SLC25A8 mitochondrial uncoupling protein 2 solute carrier family 25 member 8 uncoupling protein 2 (mitochondrial, proton carrier)
Gene_family	Solute carriers
organism	Homo sapiens
entrez_id	7351
location	11q13.4
transcript_count	8
exon_count	11

Cross References

Location

by NCBI GRCh38.p14

Summary

Entrez Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]

Stringdb Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat; Belongs to the mitochondrial carrier (TC 2.A.29) family

nextProt UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

Interactions

NCBI

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UCP2	BioGRID	ZG16B	GeneID	BioGRID	Affinity Capture-MS
UCP2	BioGRID	BTBD1	GeneID	BioGRID	Affinity Capture-MS
UCP2	BioGRID	CRNN	GeneID	BioGRID	Affinity Capture-MS
UCP2	BioGRID	SERPINB4	GeneID	BioGRID	Affinity Capture-MS
UCP2	BioGRID	SERPINB3	GeneID	BioGRID	Affinity Capture-MS
UCP2	BioGRID	S100A6	GeneID	BioGRID	Affinity Capture-MS
UCP2	BioGRID	MUC7	GeneID	BioGRID	Affinity Capture-MS
UCP2	BioGRID	IGHA2	GeneID	BioGRID	Affinity Capture-MS
UCP2	BioGRID	FLG	GeneID	BioGRID	Affinity Capture-MS
UCP2	BioGRID	CST4	GeneID	BioGRID	Affinity Capture-MS

Showing 1 to 10 of 31 entries

StringDB

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UCP2	TBC1D1	145	215	1	1
UCP2	MTCH2	193	193	1	1
UCP2	GPX8	134	385	1	1
UCP2	GSK3B	170	226	1	2
UCP2	SLC11A1	101	150	1	1
UCP2	CAPN10	277	277	1	2
UCP2	SST	195	195	1	1
UCP2	GK	124	167	1	1
UCP2	CDKN2A	155	154	1	2
UCP2	FABP4	508	518	1	1

Showing 1 to 10 of 980 entries

Ontologies

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GO:0000266	Biological Process	mitochondrial fission	involved_in	ISS
GO:0000303	Biological Process	response to superoxide	involved_in	IEA
GO:0001666	Biological Process	response to hypoxia	involved_in	IDA
GO:0005515	Molecular Function	protein binding	enables	IPI
GO:0005739	Cellular Component	mitochondrion	located_in	IDA
GO:0005743	Cellular Component	mitochondrial inner membrane	located_in	TAS
GO:0006096	Biological Process	glycolytic process	involved_in	IMP
GO:0006541	Biological Process	glutamine metabolic process	involved_in	IMP
GO:0006839	Biological Process	mitochondrial transport	involved_in	IEA
GO:0007565	Biological Process	female pregnancy	involved_in	IEA

Showing 1 to 10 of 44 entries

Pathways

Name	DB	ID
The citric acid (TCA) cycle and respiratory electron transport	Reactome	R-HSA-1428517
Metabolism	Reactome	R-HSA-1430728
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	Reactome	R-HSA-163200
Mitochondrial Uncoupling	Reactome	R-HSA-166187
The fatty acid cycling model	Reactome	R-HSA-167826
The proton buffering model	Reactome	R-HSA-167827
Electron transport chain: OXPHOS system in mitochondria (WP111)	WikiPathways	WP111_r117097
Ketogenesis and ketolysis (WP4742)	WikiPathways	WP4742_r122056
Energy metabolism (WP1541)	WikiPathways	WP1541_r117711

Transcripts

Accession	Version	MolecularType	Name	NCBI	Comments
NM_001381944	1	mRNA	transcript variant 3	NC_000011	Reference
NM_001381948	1	mRNA	transcript variant 6	NC_000011	Reference
NM_001381950	1	mRNA	transcript variant 8	NC_000011	Reference
NM_001381949	1	mRNA	transcript variant 7	NC_000011	Reference
NM_003355	3	mRNA	transcript variant 2	NC_000011	Reference
NM_001381945	1	mRNA	transcript variant 4	NC_000011	Reference
NM_001381947	1	mRNA	transcript variant 5	NC_000011	Reference
NM_001381943	1	mRNA	transcript variant 1	NC_000011	Reference