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XIST

X inactive specific transcript
General Information
Name X inactive specific transcript
Alias
  • X inactive specific transcript (non-protein coding)
  • long intergenic non-protein coding RNA 1
Gene_family Long non-coding RNAs with non-systematic symbols
organism Homo sapiens
entrez_id 7503
location Xq13.2
transcript_count 1
exon_count 6
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome, and is essential for the initiation and spread of X-inactivation. The transcript is a spliced RNA. Alternatively spliced transcript variants have been identified, but their full length sequences have not been determined. Mutations in the XIST promoter cause familial skewed X inactivation. [provided by RefSeq, Apr 2012]
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
XIST BioGRID EIF4G2 GeneID BioGRID Affinity Capture-RNA
XIST BioGRID AGO2 GeneID BioGRID Affinity Capture-RNA
XIST BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
XIST BioGRID CHD4 GeneID BioGRID Affinity Capture-RNA
XIST BioGRID NXF1 GeneID BioGRID Protein-RNA
XIST BioGRID MAGOH GeneID BioGRID Protein-RNA
XIST BioGRID H3C14 GeneID BioGRID Co-localization
XIST BioGRID BRCA1 GeneID BioGRID Co-localization
XIST BioGRID BARD1 GeneID BioGRID Co-localization
StringDB
A B experiments database textmining combined score hadb nhadb
Ontologies
ID Category Term Effect Evidence PubMed
GO:0140463 Molecular Function chromatin-protein adaptor activity enables IDA
GO:0140869 Molecular Function miRNA inhibitor activity via base-pairing enables IDA
GO:0140719 Biological Process constitutive heterochromatin formation involved_in TAS
GO:0000512 Biological Process lncRNA-mediated post-transcriptional gene silencing involved_in IDA
GO:2000627 Biological Process positive regulation of miRNA catabolic process involved_in IDA
GO:0060816 Biological Process random inactivation of X chromosome involved_in IEP
GO:0060816 Biological Process random inactivation of X chromosome involved_in TAS
GO:0000805 Cellular Component X chromosome located_in TAS
GO:0046536 Cellular Component dosage compensation complex part_of TAS
GO:1990904 Cellular Component ribonucleoprotein complex part_of IDA
Pathways
Name DB ID
Burn wound healing (WP5055) WikiPathways WP5055_r122621
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_001564 2 ncRNA None NC_000023 Reference