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FTO

FTO alpha-ketoglutarate dependent dioxygenase
General Information
Name FTO alpha-ketoglutarate dependent dioxygenase
Alias
  • alpha-ketoglutarate-dependent dioxygenase FTO
  • AlkB homolog 9
  • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
  • fat mass and obesity associated
  • fat mass and obesity-associated protein
  • intragenic FTO exon 9 containing transcript
  • m6A(m)-demethylase FTO
  • mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • mRNA N(6)-methyladenosine demethylase FTO
  • tRNA N1-methyl adenine demethylase FTO
Gene_family Alkylation repair homologs
organism Homo sapiens
entrez_id 79068
location 16q12.2
transcript_count 25
exon_count 17
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
    Stringdb Alpha-ketoglutarate-dependent dioxygenase FTO; Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1- methylguanine. Has no detectable activity towards doubl [...]
    nextProt RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:26458103, PubMed:28002401, PubMed:30197295, PubMed:26457839, PubMed:25452335). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103, PubMed:30197295, PubMed:26457839, PubMed:25452335). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
FTO BioGRID PRNP GeneID BioGRID Affinity Capture-MS
FTO BioGRID DDA1 GeneID BioGRID Proximity Label-MS
FTO BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
FTO BioGRID CCNF GeneID BioGRID Proximity Label-MS
FTO BioGRID DIS3L2 GeneID BioGRID Co-fractionation
FTO BioGRID ZC3H15 GeneID BioGRID Co-fractionation
FTO BioGRID ZMYM3 GeneID BioGRID Co-fractionation
FTO BioGRID AIMP2 GeneID BioGRID Affinity Capture-MS
FTO BioGRID TRIM5 GeneID BioGRID Affinity Capture-MS
FTO BioGRID IQGAP1 GeneID BioGRID Affinity Capture-Western
FTO BioGRID AMD1 GeneID BioGRID Affinity Capture-Western
FTO BioGRID PGAP2 GeneID BioGRID Affinity Capture-MS
FTO BioGRID CRCP GeneID BioGRID Affinity Capture-MS
FTO BioGRID RNF144A GeneID BioGRID Affinity Capture-MS
FTO BioGRID CARTPT GeneID BioGRID Affinity Capture-MS
FTO BioGRID ZNF232 GeneID BioGRID Affinity Capture-MS
FTO BioGRID SLC2A5 GeneID BioGRID Affinity Capture-MS
FTO BioGRID SDC1 GeneID BioGRID Affinity Capture-MS
FTO BioGRID NFYA GeneID BioGRID Affinity Capture-MS
FTO BioGRID HOXC5 GeneID BioGRID Affinity Capture-MS
FTO BioGRID GPX7 GeneID BioGRID Affinity Capture-MS
FTO BioGRID FGB GeneID BioGRID Affinity Capture-MS
FTO BioGRID ALX3 GeneID BioGRID Affinity Capture-MS
FTO BioGRID NAT1 GeneID BioGRID Affinity Capture-MS
FTO BioGRID SPANXN5 GeneID BioGRID Affinity Capture-MS
FTO BioGRID SPANXN4 GeneID BioGRID Affinity Capture-MS
FTO BioGRID OR5F1 GeneID BioGRID Affinity Capture-MS
FTO BioGRID SPRED2 GeneID BioGRID Affinity Capture-MS
FTO BioGRID C19orf25 GeneID BioGRID Affinity Capture-MS
FTO BioGRID MTPN GeneID BioGRID Affinity Capture-MS
FTO BioGRID FLACC1 GeneID BioGRID Affinity Capture-MS
FTO BioGRID TYW3 GeneID BioGRID Affinity Capture-MS
FTO BioGRID GNG8 GeneID BioGRID Affinity Capture-MS
FTO BioGRID FSD1 GeneID BioGRID Affinity Capture-MS
FTO BioGRID ZMAT3 GeneID BioGRID Affinity Capture-MS
FTO BioGRID MAGEF1 GeneID BioGRID Affinity Capture-MS
FTO BioGRID ENTPD7 GeneID BioGRID Affinity Capture-MS
FTO BioGRID OSGEP GeneID BioGRID Affinity Capture-MS
FTO BioGRID CDKN2AIP GeneID BioGRID Affinity Capture-MS
FTO BioGRID DIRAS2 GeneID BioGRID Affinity Capture-MS
FTO BioGRID GNG2 GeneID BioGRID Affinity Capture-MS
FTO BioGRID RIPK4 GeneID BioGRID Affinity Capture-MS
FTO BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
FTO BioGRID OGT GeneID BioGRID Reconstituted Complex
FTO BioGRID H2BC8 GeneID BioGRID Proximity Label-MS
FTO BioGRID TULP3 GeneID BioGRID Affinity Capture-MS
FTO BioGRID KLHL38 GeneID BioGRID Two-hybrid
FTO BioGRID CCDC57 GeneID BioGRID Two-hybrid
FTO BioGRID MORN3 GeneID BioGRID Two-hybrid
FTO BioGRID DTX2 GeneID BioGRID Two-hybrid
FTO BioGRID PRDM6 GeneID BioGRID Two-hybrid
FTO BioGRID ZNF77 GeneID BioGRID Two-hybrid
FTO BioGRID AIRIM GeneID BioGRID Two-hybrid
FTO BioGRID TTC19 GeneID BioGRID Two-hybrid
FTO BioGRID SHC3 GeneID BioGRID Two-hybrid
FTO BioGRID GNG13 GeneID BioGRID Two-hybrid
FTO BioGRID EFEMP2 GeneID BioGRID Two-hybrid
FTO BioGRID TNPO2 GeneID BioGRID Two-hybrid
FTO BioGRID ANKRD11 GeneID BioGRID Two-hybrid
FTO BioGRID CLP1 GeneID BioGRID Two-hybrid
FTO BioGRID USP20 GeneID BioGRID Two-hybrid
FTO BioGRID NXF1 GeneID BioGRID Two-hybrid
FTO BioGRID MAD2L2 GeneID BioGRID Two-hybrid
FTO BioGRID GPANK1 GeneID BioGRID Two-hybrid
FTO BioGRID IL16 GeneID BioGRID Two-hybrid
FTO BioGRID CLUAP1 GeneID BioGRID Affinity Capture-MS
FTO BioGRID RECQL4 GeneID BioGRID Affinity Capture-MS
FTO BioGRID SBF2 GeneID BioGRID Proximity Label-MS
FTO BioGRID MPZL1 GeneID BioGRID Affinity Capture-MS
FTO BioGRID BCCIP GeneID BioGRID Co-fractionation
FTO BioGRID CNDP2 GeneID BioGRID Co-fractionation
FTO BioGRID TKFC GeneID BioGRID Co-fractionation
FTO BioGRID NDRG1 GeneID BioGRID Co-fractionation
FTO BioGRID NPEPPS GeneID BioGRID Co-fractionation
FTO BioGRID NHERF1 GeneID BioGRID Co-fractionation
FTO BioGRID CTSA GeneID BioGRID Co-fractionation
FTO BioGRID PEPD GeneID BioGRID Co-fractionation
FTO BioGRID MVD GeneID BioGRID Co-fractionation
FTO BioGRID LDHB GeneID BioGRID Co-fractionation
FTO BioGRID LDHA GeneID BioGRID Co-fractionation
FTO BioGRID EEF2 GeneID BioGRID Co-fractionation
FTO BioGRID CKB GeneID BioGRID Co-fractionation
StringDB
A B experiments database textmining combined score hadb nhadb
FTO TPMT 0 0 265 265 1 1
FTO CHRNA3 0 0 246 245 1 1
FTO BUD13 0 0 134 166 1 1
FTO EMX2 0 0 81 215 1 1
FTO GHRL 0 0 623 623 1 1
FTO ZNF572 0 0 124 216 1 1
FTO PPARD 0 0 195 195 1 1
FTO ALKBH3 0 0 706 738 1 1
FTO ZSCAN1 0 0 167 167 1 1
FTO LY86 0 0 193 193 1 1
FTO EIF3H 0 0 138 168 1 1
FTO CHST11 0 0 219 219 1 1
FTO YTHDC1 0 0 739 790 1 1
FTO SRSF1 0 0 101 153 1 1
FTO PAX4 0 0 170 169 1 1
FTO MIA3 0 0 171 171 1 1
FTO SFPQ 0 0 130 169 1 1
FTO MTAP 0 0 142 232 1 1
FTO PCSK5 0 0 57 220 1 1
FTO STAT3 0 0 209 217 1 2
FTO RBMS1 0 0 260 260 1 1
FTO TYW5 0 0 315 320 1 1
FTO PLIN4 0 0 112 249 1 1
FTO FITM2 0 0 231 230 1 1
FTO PTPN22 0 0 218 218 1 1
FTO RASGRP1 0 0 106 161 1 1
FTO USP37 0 0 95 191 1 1
FTO MAOA 0 0 167 167 1 1
FTO CCRN4L 0 0 90 165 1 1
FTO IRX2 0 0 63 382 1 1
FTO LEPROT 0 0 96 152 1 1
FTO TP53 0 0 234 234 1 2
FTO EGFR 0 0 150 211 1 2
FTO RREB1 0 0 155 215 1 1
FTO ZNF608 0 0 456 456 1 1
FTO NRXN3 0 0 556 569 1 1
FTO SKOR1 0 0 278 278 1 1
FTO GNL3 0 0 184 183 1 1
FTO SLC2A2 0 0 248 248 1 1
FTO HPDL 0 0 0 210 1 1
FTO PTPRD 0 0 289 288 1 1
FTO LMX1B 0 0 166 165 1 1
FTO PDCD2 0 0 0 248 1 1
FTO BCAS3 0 0 183 183 1 1
FTO KLHL32 0 0 181 186 1 1
FTO ASPH 0 0 320 325 1 1
FTO PANO 0 0 193 193 1 1
FTO SUGP1 0 0 166 172 1 1
FTO GKAP1 0 0 90 183 1 1
FTO NPY4R 0 0 181 181 1 1
FTO RNMT 0 0 455 455 1 1
FTO HOXB5 0 0 260 260 1 1
FTO CTSA 261 0 0 298 1 1
FTO HDAC2 0 0 67 176 1 1
FTO EMX1 0 0 56 363 1 1
FTO LRP1B 0 0 372 385 1 1
FTO CMIP 0 0 213 213 1 1
FTO SRSF11 0 0 45 159 1 1
FTO PDZRN4 0 0 138 227 1 1
FTO ASB4 0 0 150 277 1 1
FTO ANKRD7 0 0 90 166 1 1
FTO DDX39A 0 0 0 194 1 1
FTO ACSL1 0 0 123 163 1 1
FTO C2CD4A 0 0 491 491 1 1
FTO CYFIP1 0 0 49 150 1 1
FTO LNPEP 0 0 0 154 1 1
FTO GNG12 0 0 83 161 1 1
FTO CIDEA 0 0 142 165 1 1
FTO ZNF423 0 0 140 170 1 1
FTO MBD2 0 0 200 200 1 1
FTO BBS2 0 0 235 251 1 1
FTO MAP2K5 0 0 460 459 1 1
FTO ZNF169 0 0 202 202 1 1
FTO NEGR1 0 0 759 780 1 1
FTO ENDOV 0 0 55 226 1 1
FTO NPY 0 0 402 421 1 1
FTO BRCA1 0 0 169 253 1 2
FTO PFKM 0 0 94 150 1 1
FTO NR0B2 0 0 357 357 1 1
FTO SLC6A4 0 0 267 267 1 1
FTO CLOCK 0 0 260 260 1 2
FTO BCDIN3D 0 0 519 519 1 1
FTO MYC 0 0 292 292 1 2
FTO DGAT1 0 0 149 202 1 2
FTO STK32B 0 0 74 171 1 1
FTO WFS1 0 0 654 654 1 1
FTO POLL 0 0 235 235 1 1
FTO PPARGC1A 0 0 394 394 1 2
FTO PCK1 0 0 269 270 1 1
FTO ADAM30 0 0 394 394 1 1
FTO IGF1R 0 0 108 157 1 2
FTO SDHC 0 0 136 154 1 1
FTO GRB14 0 0 470 470 1 1
FTO MSRA 0 0 469 469 1 1
FTO NPC1 0 0 505 505 1 2
FTO EGLN3 0 0 123 161 1 1
FTO PHAX 0 0 0 194 1 1
FTO APOH 0 0 435 435 1 1
FTO IRX5 0 0 681 687 1 1
FTO YTHDF2 0 0 804 848 1 1
FTO G6PC 0 0 210 210 1 1
FTO TMEM154 0 0 175 231 1 1
FTO ACACA 0 0 180 181 1 1
FTO MICU1 0 0 0 382 1 1
FTO IL2RA 0 0 123 157 1 1
FTO CASC5 0 0 0 190 1 1
FTO TFAP2B 0 0 607 607 1 1
FTO CCDC171 0 0 142 286 1 1
FTO PUS7 0 0 254 296 1 1
FTO IGF2BP2 0 0 752 752 1 1
FTO TRMT61B 0 0 193 193 1 1
FTO GNRHR 0 0 159 173 1 1
FTO LINGO2 0 0 455 455 1 1
FTO MCPH1 0 0 61 272 1 1
FTO BBS4 0 0 172 171 1 1
FTO C7orf31 0 0 211 211 1 1
FTO HENMT1 0 0 171 171 1 1
FTO DNMT3B 0 0 211 221 1 1
FTO APOM 0 0 67 165 1 1
FTO TNRC6B 0 0 95 474 1 1
FTO DNMT3A 0 0 213 213 1 2
FTO PSRC1 0 0 302 302 1 1
FTO CNOT1 0 0 134 290 1 1
FTO GAPDH 0 0 279 294 1 2
FTO TRMT6 0 0 269 293 1 1
FTO SH2B3 0 0 217 222 1 1
FTO NNT 0 0 46 211 1 1
FTO CORO7-PAM16 0 0 45 212 1 1
FTO BCCIP 129 0 0 245 1 1
FTO KIF1A 0 0 0 261 1 1
FTO CSMD1 0 0 139 190 1 1
FTO NSUN2 0 0 464 509 1 1
FTO APOA1 0 0 232 231 1 1
FTO RPS6KA5 0 0 0 161 1 1
FTO TCF7L2 0 0 802 805 1 1
FTO CLIP1 0 0 68 185 1 1
FTO DGCR8 0 0 252 253 1 1
FTO GCKR 0 0 415 441 1 1
FTO MBOAT4 0 0 107 201 1 1
FTO ADCY9 0 0 160 159 1 1
FTO KCNJ11 0 0 683 683 1 1
FTO RUNX1T1 0 0 520 557 1 1
FTO CLUAP1 270 0 0 288 1 1
FTO RALYL 0 0 247 246 1 1
FTO CREB1 0 0 203 325 1 2
FTO HIST2H2AC 0 0 96 252 1 1
FTO HSD11B1 0 0 185 185 1 1
FTO STARD3NL 0 0 161 174 1 1
FTO PERP 0 0 0 254 1 1
FTO FOXM1 0 0 294 326 1 1
FTO TAGLN 0 0 0 208 1 1
FTO SPATS2 0 0 95 174 1 1
FTO NPEPPS 245 0 0 415 1 1
FTO PCSK6 0 0 90 247 1 1
FTO C16orf78 0 0 244 243 1 1
FTO FGF21 0 0 261 261 1 2
FTO GTF2A1L 0 0 120 160 1 1
FTO INTU 0 0 0 171 1 1
FTO FAM13A 0 0 283 282 1 1
FTO STON1 0 0 211 235 1 1
FTO SIRT2 0 0 123 183 1 2
FTO NSUN6 0 0 213 241 1 1
FTO NPIPB9 0 0 167 167 1 1
FTO CCDC121 0 0 117 172 1 1
FTO C4orf22 0 0 108 163 1 1
FTO MAST1 0 0 0 208 1 1
FTO ANKRD52 0 0 95 171 1 1
FTO ABCB11 0 0 160 159 1 1
FTO RPGRIP1L 0 0 727 756 1 1
FTO XPNPEP1 0 0 0 173 1 1
FTO SORT1 0 0 270 270 1 1
FTO CORO7 0 0 45 212 1 1
FTO ADAR 0 0 213 217 1 1
FTO TRIB2 0 0 91 328 1 1
FTO MTOR 0 0 232 231 1 2
FTO NUDT3 0 0 556 556 1 1
FTO IL6 0 0 284 284 1 2
FTO NCOA5 0 0 0 152 1 1
FTO PLIN1 0 0 324 323 1 1
FTO UCP2 0 0 534 534 1 2
FTO LEPRE1 0 0 74 163 1 1
FTO DCST2 0 0 124 216 1 1
FTO FABP6 0 0 57 151 1 1
FTO DNAJC28 0 0 74 171 1 1
FTO LGR4 0 0 142 457 1 1
FTO TRIM66 0 0 203 249 1 1
FTO HIF3A 0 0 324 348 1 1
FTO ZFP64 0 0 160 244 1 1
FTO HIF1A 0 0 229 228 1 2
FTO SEC16B 0 0 758 759 1 2
FTO GCK 0 0 323 323 1 1
FTO PRRC2A 0 0 324 328 1 1
FTO BBS1 0 0 135 166 1 1
FTO PPP2R2D 0 0 0 154 1 1
FTO FSHB 0 0 160 159 1 1
FTO VSTM2L 0 0 94 251 1 1
FTO KCNQ1 0 0 637 637 1 1
FTO METTL1 0 0 143 384 1 1
FTO NDRG1 245 0 0 244 1 1
FTO MTNR1A 0 0 95 159 1 1
FTO KIAA1429 0 0 737 783 1 1
FTO NUDT15 0 0 328 328 1 1
FTO LIPE 0 0 243 242 1 1
FTO GALNT10 0 0 304 325 1 1
FTO CTNNB1 0 0 210 213 1 2
FTO ERAP1 0 0 57 169 1 1
FTO TBC1D22B 0 0 126 343 1 1
FTO MSI1 0 0 96 236 1 1
FTO SERPINA12 0 0 157 163 1 1
FTO ZNF28 0 0 161 194 1 1
FTO INS 0 0 659 659 1 2
FTO ACTB 0 0 283 294 1 2
FTO UHRF1BP1 0 0 240 239 1 1
FTO DNMT1 0 0 248 255 1 2
FTO GLP1R 0 0 194 194 1 1
FTO EPRS 0 0 66 201 1 1
FTO ABCG1 0 0 181 181 1 2
FTO IGSF10 0 0 159 158 1 1
FTO PCK2 0 0 241 240 1 1
FTO GLI3 0 0 50 152 1 1
FTO CAPN12 0 0 94 156 1 1
FTO GRASP 0 0 113 152 1 1
FTO PNPLA2 0 0 155 285 1 2
FTO ANKHD1-EIF4EBP3 0 0 0 375 1 1
FTO HDAC4 0 0 151 243 1 2
FTO CEBPA 270 0 325 487 1 1
FTO SOX2 0 0 167 167 1 2
FTO ACTN3 0 0 284 316 1 1
FTO NEUROD1 0 0 125 171 1 1
FTO ALX4 0 0 136 199 1 1
FTO CRP 0 0 391 390 1 2
FTO VPS13C 0 0 129 168 1 1
FTO CLEC16A 0 0 154 172 1 2
FTO MYO1G 0 0 150 188 1 1
FTO KPNA5 0 0 0 190 1 1
FTO PMCH 0 0 105 156 1 1
FTO IGFBP2 0 0 218 218 1 1
FTO COBLL1 0 0 392 392 1 1
FTO ADH1B 0 0 226 225 1 1
FTO SCML4 0 0 86 242 1 1
FTO SFTA3 0 0 391 390 1 1
FTO GALNT3 0 0 46 204 1 1
FTO TMC2 0 0 59 222 1 1
FTO METTL4 0 0 533 578 1 1
FTO NDUFAF6 0 0 95 190 1 1
FTO CPEB4 0 0 136 169 1 1
FTO INSR 0 0 325 325 1 1
FTO GNRH1 0 0 154 153 1 1
FTO BANK1 0 0 97 235 1 1
FTO KDM1A 0 0 179 179 1 2
FTO CARTPT 0 0 240 239 1 1
FTO TOMM40 0 0 212 212 1 1
FTO PYY 0 0 456 456 1 1
FTO IRS2 0 0 150 203 1 1
FTO RPA2 0 0 0 254 1 1
FTO TAGLN3 0 0 0 208 1 1
FTO MAST3 0 0 0 188 1 1
FTO CAMK1D 0 0 602 602 1 1
FTO LSP1 0 0 204 204 1 1
FTO MAT2A 0 0 235 268 1 1
FTO IGF2BP3 0 0 167 167 1 1
FTO RELL1 0 0 103 280 1 1
FTO MAST2 0 0 0 208 1 1
FTO PDXDC1 0 0 141 174 1 1
FTO SLC7A10 0 0 122 182 1 1
FTO LUZP2 0 0 217 244 1 1
FTO NCBP1 0 0 143 206 1 1
FTO INSIG2 0 0 681 681 1 1
FTO ANK1 0 0 210 253 1 1
FTO POC5 0 0 505 505 1 1
FTO KDM4A 0 0 218 230 1 1
FTO TET3 0 0 294 294 1 1
FTO ZNF664 0 0 233 232 1 1
FTO NOP2 0 0 242 250 1 1
FTO ANKHD1 0 0 0 378 1 1
FTO PAF1 0 0 272 272 1 1
FTO SHISA9 0 0 81 230 1 1
FTO SP6 0 0 465 465 1 1
FTO TBL1X 0 0 181 181 1 1
FTO PARD3B 0 0 171 185 1 1
FTO CYP19A1 0 0 171 171 1 2
FTO RBMX 0 0 282 291 1 1
FTO TAZ 0 0 74 363 1 1
FTO TNKS 0 0 260 300 1 1
FTO KIF11 0 0 398 398 1 1
FTO FABP3 0 0 134 166 1 1
FTO NPY2R 0 0 231 230 1 1
FTO PFKP 0 0 323 472 1 1
FTO EXOSC4 0 0 254 257 1 1
FTO ARID5B 0 0 454 509 1 1
FTO ZSWIM2 0 0 67 270 1 1
FTO ZNF141 0 0 91 156 1 1
FTO TOX3 0 0 267 286 1 1
FTO DENND1A 0 0 264 264 1 1
FTO PER2 0 0 154 153 1 1
FTO CNEP1R1 0 0 97 188 1 1
FTO C11orf68 0 0 0 183 1 1
FTO SIX4 0 0 67 168 1 1
FTO FAM69B 0 0 117 157 1 1
FTO KIF1B 0 0 47 463 1 1
FTO SRF 0 0 55 155 1 1
FTO NANOG 0 0 251 250 1 2
FTO SREK1 0 0 71 238 1 1
FTO VCAN 0 0 94 192 1 1
FTO FAM184B 0 0 109 170 1 1
FTO POMC 0 0 556 563 1 1
FTO PNMA2 0 0 392 409 1 1
FTO AGMO 0 0 259 258 1 1
FTO FASN 0 0 233 232 1 2
FTO PCSK1 0 0 608 608 1 1
FTO EIF4A3 0 0 90 243 1 1
FTO HNF1A 0 0 181 181 1 1
FTO KIF6 0 0 157 185 1 1
FTO OLFM4 0 0 284 284 1 1
FTO IGFBP1 0 0 108 169 1 1
FTO PRKAB2 0 0 170 169 1 1
FTO CTIF 0 0 74 154 1 1
FTO EGF 0 0 155 154 1 2
FTO PUS1 0 0 171 176 1 1
FTO DICER1 0 0 161 167 1 1
FTO ENSG00000266953 0 0 0 357 1 1
FTO GPHN 0 0 0 388 1 1
FTO SEPT9 0 0 113 174 1 1
FTO ETV5 0 0 561 561 1 1
FTO CSE1L 0 0 54 174 1 1
FTO PER3 0 0 134 153 1 1
FTO ZPR1 0 0 261 261 1 1
FTO TRIB1 0 0 170 260 1 1
FTO GNAS 0 0 155 154 1 1
FTO LIN7C 0 0 147 227 1 1
FTO RPAP2 0 0 0 194 1 1
FTO CETP 0 0 455 455 1 1
FTO PPARA 0 0 297 297 1 2
FTO PPY 0 0 148 167 1 1
FTO KIAA1328 0 0 0 154 1 1
FTO TAT 0 0 144 207 1 2
FTO LPL 0 0 264 264 1 1
FTO RPTOR 0 0 82 286 1 2
FTO TRA2B 0 0 321 342 1 1
FTO KDM2A 0 0 134 188 1 1
FTO SNRNP70 0 0 171 196 1 1
FTO HIST2H3PS2 0 0 181 181 1 1
FTO SDCCAG8 0 0 324 323 1 1
FTO CLVS1 0 0 167 167 1 1
FTO TUFM 0 0 161 161 1 2
FTO MTHFD1L 0 0 162 161 1 1
FTO NR3C1 0 0 224 224 1 1
FTO CMTR1 0 0 171 181 1 1
FTO CENPW 0 0 160 161 1 1
FTO ALKBH4 0 0 517 592 1 1
FTO HNRNPA2B1 0 0 508 539 1 1
FTO XPNPEP2 0 0 0 173 1 1
FTO TRIP4 0 0 257 257 1 1
FTO ZNF217 0 0 74 170 1 1
FTO BCL11A 0 0 413 412 1 1
FTO ADIPOQ 0 0 564 564 1 2
FTO MINA 0 0 164 179 1 1
FTO PABPN1 0 0 95 152 1 1
FTO SREK1IP1 0 0 134 282 1 1
FTO PHOSPHO1 0 0 208 208 1 1
FTO ASL 0 0 70 167 1 1
FTO AKTIP 0 0 391 453 1 1
FTO GLI2 0 0 0 215 1 2
FTO IDH1 0 0 269 269 1 1
FTO IGF2BP1 0 0 391 390 1 1
FTO TMEM18 0 0 857 864 1 1
FTO NXF1 74 0 155 209 1 1
FTO HSD17B11 0 0 204 375 1 1
FTO PKD1L2 0 0 0 207 1 1
FTO MACF1 0 0 87 178 1 1
FTO EXT2 0 0 370 370 1 1
FTO MLXIPL 0 0 227 226 1 1
FTO FNDC5 0 0 150 173 1 1
FTO MAF 0 0 469 469 1 1
FTO ZNF365 0 0 219 219 1 1
FTO APOBEC1 0 0 151 152 1 1
FTO DRD2 0 0 391 392 1 1
FTO TBC1D22A 0 0 73 234 1 1
FTO ALKBH2 0 0 709 790 1 1
FTO TAS2R50 0 0 234 234 1 1
FTO ABCA1 0 0 212 212 1 2
FTO ABCC8 0 0 266 271 1 1
FTO IAPP 0 0 134 188 1 2
FTO CUX1 0 0 545 545 1 1
FTO ATP2A1 0 0 219 219 1 1
FTO ATP10A 0 0 155 154 1 1
FTO ALB 0 0 170 169 1 2
FTO VRTN 0 0 155 154 1 1
FTO IRX1 0 0 650 650 1 1
FTO CSMD2 0 0 107 191 1 1
FTO FTSJ1 0 0 166 165 1 1
FTO CLPTM1L 0 0 144 173 1 1
FTO ENPEP 0 0 0 154 1 1
FTO LEPR 0 0 557 563 1 1
FTO BBS10 0 0 136 168 1 1
FTO ELAVL1 0 0 359 378 1 2
FTO PMP2 0 0 0 165 1 1
FTO PCIF1 0 0 283 315 1 1
FTO ADRB3 0 0 459 471 1 1
FTO DUSP9 0 0 418 418 1 1
FTO NMRK1 0 0 0 248 1 1
FTO ANKRD55 0 0 264 326 1 1
FTO ADRA2A 0 0 300 300 1 1
FTO GIPR 0 0 563 563 1 1
FTO THADA 0 0 681 681 1 1
FTO ADCY5 0 0 406 406 1 1
FTO ADIPOR1 0 0 284 284 1 1
FTO CDK5 0 0 205 205 1 2
FTO ZMIZ1 0 0 180 196 1 1
FTO SNCAIP 0 0 84 161 1 2
FTO HNF1B 0 0 459 459 1 1
FTO CTNNA3 0 0 164 163 1 1
FTO PTBP2 0 0 325 325 1 1
FTO CNN2 0 0 0 208 1 1
FTO PHACTR1 0 0 211 211 1 1
FTO CRY2 0 0 180 179 1 1
FTO ABCC4 0 0 90 247 1 1
FTO ALKBH6 0 0 459 496 1 1
FTO DDX46 0 0 90 168 1 1
FTO HPRT1 0 0 146 170 1 1
FTO MICU2 0 0 0 246 1 1
FTO TNRC6A 0 0 90 186 1 1
FTO KCTD15 0 0 767 767 1 1
FTO FOXA2 0 0 161 161 1 1
FTO LDLR 0 0 204 204 1 2
FTO APOBR 0 0 257 272 1 1
FTO PRKCDBP 0 0 0 152 1 1
FTO ZC3H4 0 0 268 274 1 1
FTO GRID1 0 0 124 178 1 2
FTO ANKRD50 0 0 74 152 1 1
FTO FAH 0 0 47 414 1 1
FTO POLG2 0 0 136 156 1 1
FTO KLF9 0 0 160 159 1 1
FTO MSI2 0 0 54 155 1 1
FTO DNAJC27 0 0 519 529 1 1
FTO IDE 0 0 194 369 1 1
FTO PCSK2 0 0 166 190 1 1
FTO BARD1 0 0 0 211 1 1
FTO NPFFR2 0 0 149 180 1 1
FTO ALMS1 0 0 138 161 1 1
FTO FRMD4A 0 0 210 290 1 1
FTO SLC9A3R1 153 0 0 231 1 1
FTO NT5C2 0 0 280 289 1 1
FTO SLC39A8 0 0 402 402 1 1
FTO OPRM1 0 0 181 197 1 1
FTO FH 0 0 160 159 1 1
FTO FADS1 0 0 334 334 1 1
FTO FADS2 0 0 216 216 1 1
FTO HPD 0 0 98 530 1 1
FTO ZNF596 0 0 208 208 1 1
FTO ENSG00000264813 0 0 347 347 1 1
FTO TMEM160 0 0 503 503 1 1
FTO SCAI 0 0 214 241 1 1
FTO TRMT2A 0 0 70 169 1 1
FTO GLT8D1 0 0 325 325 1 1
FTO IRS1 0 0 518 518 1 2
FTO ADRB2 0 0 337 337 1 1
FTO PGC 0 0 122 256 1 1
FTO SERPINE1 0 0 157 156 1 1
FTO SCG3 0 0 137 152 1 1
FTO EIF4E 0 0 211 212 1 2
FTO PPP1R3B 0 0 325 325 1 1
FTO FSHR 0 0 140 163 1 1
FTO SREBF2 0 0 134 226 1 1
FTO INS-IGF2 0 0 150 235 1 1
FTO MSANTD1 0 0 150 173 1 1
FTO PRKAA1 0 0 112 174 1 2
FTO ARAP1 0 0 517 517 1 1
FTO ALDH2 0 0 210 210 1 2
FTO C14orf169 0 0 166 172 1 1
FTO ZNF512 0 0 108 168 1 1
FTO FAM192A 0 0 0 411 1 1
FTO PPM1K 0 0 138 169 1 1
FTO MEPCE 0 0 151 150 1 1
FTO MTHFR 0 0 424 424 1 1
FTO MARC1 0 0 171 177 1 1
FTO MTIF3 0 0 556 556 1 1
FTO SPTBN5 0 0 81 215 1 1
FTO ASCC3 0 0 165 165 1 1
FTO THNSL2 0 0 241 255 1 1
FTO NFE2L3 0 0 193 193 1 1
FTO TXNIP 0 0 167 254 1 2
FTO PROX1 0 0 284 284 1 1
FTO SRSF2 0 0 440 485 1 1
FTO CTNNBL1 0 0 518 568 1 1
FTO TAS1R2 0 0 101 239 1 1
FTO CPED1 0 0 134 157 1 1
FTO QPCTL 0 0 561 561 1 1
FTO FAM71F1 0 0 454 454 1 1
FTO METTL13 0 0 182 208 1 1
FTO YTHDF3 0 0 731 784 1 1
FTO SPRY2 0 0 244 256 1 1
FTO RPS6KA2 0 0 47 211 1 1
FTO AGT 0 0 156 155 1 1
FTO GCG 0 0 334 360 1 1
FTO APOC3 0 0 270 270 1 1
FTO ERAP2 0 0 0 154 1 1
FTO APOB 0 0 324 323 1 2
FTO CCDC144A 0 0 0 174 1 1
FTO PTER 0 0 561 561 1 1
FTO IGF1 0 0 310 309 1 2
FTO ARNTL 0 0 218 218 1 1
FTO ZNF85 0 0 123 208 1 1
FTO GFOD2 0 0 259 258 1 1
FTO LIPG 0 0 123 152 1 1
FTO PKM 0 0 103 198 1 1
FTO EXOC3L2 0 0 216 332 1 1
FTO RETN 0 0 290 290 1 1
FTO BDNF 0 0 603 603 1 2
FTO MC3R 0 0 607 607 1 1
FTO TDG 0 0 244 243 1 1
FTO MMP3 0 0 81 161 1 1
FTO HMG20A 0 0 457 459 1 1
FTO HTR2C 0 0 323 323 1 1
FTO KDM3A 0 0 157 244 1 1
FTO VDR 0 0 202 202 1 2
FTO CHIA 0 0 218 218 1 1
FTO UCP3 0 0 334 334 1 1
FTO ADAMTS9 0 0 613 613 1 1
FTO LCT 0 0 193 193 1 1
FTO LHX9 0 0 0 213 1 1
FTO TNF 0 0 234 234 1 2
FTO PSMD6 0 0 212 212 1 1
FTO MIPOL1 0 0 0 194 1 1
FTO ELP2 0 0 119 212 1 1
FTO FMR1 0 0 193 193 1 1
FTO DDX3X 0 0 73 165 1 1
FTO EEF2 129 0 62 167 1 2
FTO ANKRD36 0 0 0 165 1 1
FTO ATXN2L 0 0 150 150 1 1
FTO CBLL1 0 0 457 457 1 1
FTO ANKK1 0 0 290 290 1 1
FTO LYPLAL1 0 0 602 602 1 1
FTO PRDM16 0 0 204 204 1 1
FTO RSPO3 0 0 261 261 1 1
FTO RBM15B 0 0 564 599 1 1
FTO ALKBH8 0 0 681 700 1 1
FTO ARL15 0 0 380 380 1 1
FTO CYP21A2 0 0 69 165 1 1
FTO FBN3 0 0 235 235 1 1
FTO C2orf27A 0 0 155 154 1 1
FTO PPARG 0 0 663 663 1 2
FTO MAGEL2 0 0 155 162 1 1
FTO CPT1A 0 0 230 229 1 1
FTO AKT1 0 0 241 240 1 2
FTO NDUFAF3 0 0 205 205 1 1
FTO ZMAT3 431 0 0 431 1 1
FTO LHX2 0 0 0 213 1 1
FTO PHF2 0 0 181 202 1 1
FTO RPGRIP1 0 0 299 299 1 1
FTO DROSHA 0 0 145 168 1 1
FTO SSBP4 0 0 202 202 1 1
FTO MTNR1B 0 0 661 661 1 1
FTO GALNT6 0 0 47 307 1 1
FTO FABP2 0 0 325 325 1 1
FTO R3HDML 0 0 254 254 1 1
FTO LGR6 0 0 218 218 1 1
FTO DGKG 0 0 325 325 1 1
FTO TRHDE 0 0 0 154 1 1
FTO NTRK2 0 0 218 283 1 1
FTO ACACB 0 0 124 178 1 1
FTO MZF1 0 0 155 155 1 1
FTO GSTM1 0 0 217 217 1 1
FTO DRD4 0 0 203 203 1 1
FTO TMEM51 0 0 92 187 1 1
FTO BSCL2 0 0 134 167 1 1
FTO GPRC5B 0 0 391 390 1 1
FTO RALY 0 0 142 171 1 1
FTO PHGDH 0 0 77 243 1 1
FTO NDUFB6 0 0 142 172 1 1
FTO SUPT3H 0 0 232 231 1 1
FTO NSUN7 0 0 170 171 1 1
FTO GPT 0 0 160 159 1 1
FTO CCK 0 0 234 234 1 1
FTO CSMD3 0 0 103 154 1 1
FTO BSND 0 0 46 212 1 1
FTO CEP120 0 0 62 176 1 1
FTO ADCK5 0 0 108 172 1 1
FTO TAS1R1 0 0 57 202 1 1
FTO ATOH1 0 0 0 213 1 1
FTO CADM2 0 0 468 468 1 1
FTO UBE2E2 0 0 283 296 1 1
FTO HMGA2 0 0 272 272 1 1
FTO OGFOD1 0 0 210 354 1 1
FTO ERBB2 0 0 148 209 1 2
FTO SNAPC2 0 0 95 155 1 1
FTO FBXL17 0 0 233 232 1 1
FTO BRINP2 0 0 157 156 1 1
FTO SHBG 0 0 322 321 1 1
FTO TRMT10A 0 0 441 441 1 1
FTO DNAH3 0 0 57 200 1 1
FTO PKD2 0 0 0 183 1 2
FTO SRGAP3 0 0 0 191 1 1
FTO ANAPC4 0 0 108 217 1 1
FTO SPRTN 0 0 0 189 1 1
FTO SCD 0 0 180 179 1 1
FTO EED 0 0 47 191 1 1
FTO CRTC1 0 0 193 193 1 2
FTO APOC1 0 0 246 245 1 1
FTO TP53I11 0 0 124 218 1 1
FTO MKL1 0 0 167 167 1 1
FTO WARS2 0 0 161 278 1 1
FTO ENSG00000279890 0 0 0 230 1 1
FTO CRY1 0 0 669 669 1 1
FTO OXT 0 0 180 179 1 1
FTO FEZF2 0 0 46 151 1 1
FTO SLC2A4 0 0 253 252 1 1
FTO METTL3 0 0 858 881 1 2
FTO FSIP2 0 0 67 216 1 1
FTO APOE 0 0 567 567 1 2
FTO TM6SF2 0 0 233 288 1 1
FTO PCSK9 0 0 268 288 1 1
FTO ZBED3 0 0 414 414 1 1
FTO COMT 0 0 247 248 1 1
FTO ALYREF 0 0 184 236 1 1
FTO TERF2IP 0 0 216 216 1 1
FTO HNF4A 0 0 323 323 1 1
FTO JMJD4 0 0 171 172 1 1
FTO TRUB1 0 0 140 155 1 1
FTO TP53INP1 0 0 247 248 1 2
FTO MAP3K19 0 0 244 249 1 1
FTO HTR2A 0 0 151 150 1 1
FTO HDHD1 0 0 81 224 1 1
FTO ZFAND6 0 0 422 422 1 1
FTO SLC30A8 0 0 739 739 1 1
FTO ANKRD17 0 0 73 428 1 1
FTO ROBO2 0 0 0 158 1 1
FTO SIM1 0 0 391 397 1 1
FTO MVD 129 0 0 407 1 1
FTO XPNPEP3 0 0 0 194 1 1
FTO DDX39B 0 0 60 243 1 1
FTO CCDC92 0 0 241 246 1 1
FTO SLC37A1 0 0 73 169 1 1
FTO CNN3 0 0 0 386 1 1
FTO ADAMTSL3 0 0 323 555 1 1
FTO DGKB 0 0 395 417 1 1
FTO ANPEP 0 0 0 154 1 1
FTO CHST8 0 0 269 269 1 1
FTO YTHDC2 0 0 681 705 1 1
FTO SORCS1 0 0 107 155 1 1
FTO ZC3H13 0 0 607 620 1 1
FTO METTL14 0 0 857 944 1 1
FTO LIN28B 0 0 181 181 1 1
FTO NUDT6 0 0 54 269 1 1
FTO ADIPOR2 0 0 252 252 1 1
FTO TRMT5 0 0 122 177 1 1
FTO PUS3 0 0 150 172 1 1
FTO DCP2 0 0 338 371 1 1
FTO NPIPB8 0 0 182 181 1 1
FTO CNN1 0 0 0 208 1 1
FTO IRX6 0 0 769 769 1 1
FTO DIO2 0 0 85 183 1 1
FTO CTCF 0 0 211 211 1 1
FTO SBF2 131 0 74 242 1 1
FTO KCNQ5 0 0 65 158 1 1
FTO CDKAL1 0 0 803 820 1 1
FTO C17orf104 0 0 241 240 1 1
FTO MC4R 0 0 870 884 1 1
FTO REN 0 0 135 150 1 1
FTO TONSL 0 0 52 156 1 1
FTO RFX7 0 0 130 222 1 1
FTO CREG2 0 0 181 286 1 1
FTO NOTCH2 0 0 459 459 1 1
FTO ACE 0 0 365 365 1 1
FTO ZWILCH 0 0 0 207 1 1
FTO SMUG1 0 0 134 259 1 1
FTO TET1 0 0 334 334 1 1
FTO WTAP 0 0 856 883 1 1
FTO CREBRF 0 0 249 248 1 1
FTO BRCA2 0 0 184 240 1 1
FTO HDAC9 0 0 109 263 1 1
FTO KLF14 0 0 468 468 1 1
FTO EGLN1 0 0 246 263 1 1
FTO RPE 0 0 45 150 1 1
FTO HCRT 0 0 181 198 1 1
FTO DEXI 0 0 280 289 1 1
FTO NLN 0 0 407 407 1 1
FTO ZFAND3 0 0 322 321 1 1
FTO SLC6A14 0 0 540 540 1 1
FTO POU6F2 0 0 73 216 1 1
FTO MLLT3 0 0 165 187 1 1
FTO LIPC 0 0 370 370 1 1
FTO ENPP1 0 0 433 433 1 1
FTO TUB 0 0 265 265 1 1
FTO TNNI3K 0 0 566 566 1 1
FTO NYAP2 0 0 96 161 1 1
FTO RASA2 0 0 67 162 1 1
FTO CEBPB 0 0 703 703 1 2
FTO CELSR2 0 0 244 260 1 1
FTO SRSF10 0 0 394 415 1 1
FTO PEPD 129 0 294 555 1 1
FTO C6orf106 0 0 270 270 1 1
FTO TBX15 0 0 184 265 1 1
FTO GHR 0 0 105 173 1 1
FTO CDC123 0 0 669 669 1 1
FTO HDAC1 0 0 95 272 1 2
FTO CKB 244 0 0 291 1 1
FTO AHSG 0 0 398 398 1 1
FTO KCNK16 0 0 269 269 1 1
FTO CCDC141 0 0 74 208 1 1
FTO NSUN4 0 0 160 178 1 1
FTO TBC1D1 0 0 242 269 1 1
FTO MTCH2 0 0 731 731 1 1
FTO CSTF2 0 0 190 201 1 1
FTO GSK3B 0 0 94 234 1 2
FTO CAPN10 0 0 556 556 1 2
FTO ZFAT 0 0 150 274 1 1
FTO SOCS2 0 0 181 181 1 1
FTO CDKN2A 0 0 518 558 1 2
FTO NUDT9 0 0 57 152 1 1
FTO EPHA3 0 0 134 267 1 1
FTO FABP4 0 0 218 229 1 1
FTO PNPLA3 0 0 324 428 1 1
FTO JAZF1 0 0 667 667 1 1
FTO ADAMTSL1 0 0 0 297 1 1
FTO MCHR2 0 0 171 171 1 1
FTO RBL2 0 0 253 457 1 1
FTO SESTD1 0 0 85 164 1 1
FTO SLC2A9 0 0 321 321 1 1
FTO PICALM 0 0 150 183 1 1
FTO PDHX 0 0 0 293 1 1
FTO PDE7B 0 0 167 202 1 1
FTO CHRNB4 0 0 171 177 1 1
FTO AP3S2 0 0 310 309 1 1
FTO TSHZ3 0 0 47 194 1 1
FTO ALKBH1 0 0 856 870 1 1
FTO JMJD6 0 0 137 180 1 1
FTO CHRNA5 0 0 321 321 1 1
FTO YTHDF1 0 0 801 852 1 1
FTO GNB3 0 0 464 463 1 1
FTO TAGLN2 0 0 0 208 1 1
FTO SH2B1 0 0 762 763 1 1
FTO FOXO1 0 0 157 242 1 2
FTO PKN2 0 0 149 202 1 1
FTO ASB2 0 0 556 637 1 1
FTO HNRNPC 0 0 517 550 1 1
FTO DDX24 0 0 0 367 1 1
FTO FILIP1 0 0 232 231 1 1
FTO SOCS3 0 0 180 179 1 1
FTO EIF3B 0 0 134 193 1 1
FTO FOS 0 0 128 151 1 2
FTO CNDP2 244 0 0 291 1 1
FTO GHSR 0 0 240 239 1 1
FTO KDM6B 0 0 134 156 1 1
FTO BSX 0 0 181 181 1 1
FTO TRDMT1 0 0 359 367 1 1
FTO GALNT2 0 0 181 181 1 1
FTO MTMR9 0 0 265 265 1 1
FTO G6PC2 0 0 390 390 1 1
FTO MCF2L 0 0 143 157 1 1
FTO PON1 0 0 270 270 1 1
FTO CILP2 0 0 244 307 1 1
FTO MCHR1 0 0 166 165 1 1
FTO GFM2 0 0 0 396 1 1
FTO LPIN1 0 0 127 235 1 2
FTO CHD9 0 0 120 163 1 1
FTO GLIS3 0 0 369 369 1 1
FTO GPR61 0 0 246 245 1 1
FTO ADCY3 0 0 456 456 1 1
FTO IRX3 0 0 812 832 1 1
FTO SLC16A11 0 0 290 290 1 1
FTO MICU3 0 0 0 246 1 1
FTO SDC1 189 0 0 189 1 1
FTO MACROD1 0 0 92 252 1 1
FTO RBM15 0 0 637 676 1 1
FTO CDKN2B 0 0 460 505 1 1
FTO CCDC170 0 0 181 181 1 1
FTO PRKCH 0 0 108 169 1 1
FTO EXOC3L1 0 0 146 298 1 1
FTO ESR1 0 0 258 258 1 2
FTO ADCY8 0 0 417 416 1 1
FTO LZTR1 0 0 161 161 1 1
FTO PDK4 0 0 195 195 1 1
FTO MBNL1 0 0 123 161 1 1
FTO SIRT1 0 0 218 218 1 2
FTO DLK1 0 0 145 187 1 1
FTO NRD1 0 0 0 369 1 1
FTO SFXN3 0 0 81 238 1 1
FTO PRKAG2 0 0 142 240 1 1
FTO APOA5 0 0 465 465 1 1
FTO RPL27A 0 0 370 370 1 1
FTO METTL16 0 0 604 628 1 1
FTO PRKD1 0 0 282 295 1 1
FTO LGR5 0 0 378 378 1 1
FTO ATG5 0 0 70 153 1 2
FTO NSUN3 0 0 296 325 1 1
FTO PPP2R2C 0 0 60 151 1 1
FTO C2CD4B 0 0 413 412 1 1
FTO ZNF430 0 0 103 189 1 1
FTO SMG6 0 0 83 150 1 1
FTO SNAP91 0 0 52 176 1 1
FTO CDK5RAP1 0 0 171 181 1 1
FTO GCC1 0 0 260 260 1 1
FTO EHBP1 0 0 91 169 1 1
FTO ADRB1 0 0 241 240 1 1
FTO ADAM19 0 0 283 282 1 1
FTO ALKBH5 0 600 871 979 1 1
FTO TERT 0 0 203 203 1 2
FTO TET2 0 0 368 368 1 2
FTO TSPAN8 0 0 607 607 1 1
FTO FANCL 0 0 276 276 1 1
FTO HNRNPDL 0 0 224 245 1 1
FTO TBP 0 0 150 165 1 1
FTO PDCD2L 0 0 0 357 1 1
FTO RARA 0 0 370 392 1 2
FTO RAD51B 0 0 163 163 1 1
FTO EIF4G2 0 0 286 335 1 1
FTO KLHL42 0 0 320 319 1 1
FTO LIG1 0 0 54 152 1 1
FTO AGRP 0 0 415 414 1 1
FTO LHCGR 0 0 171 171 1 1
FTO DIRAS2 130 0 0 155 1 1
FTO NSUN5 0 0 181 186 1 1
FTO MDM4 0 0 171 192 1 1
FTO MAST4 0 0 60 471 1 1
FTO C4orf32 0 0 337 337 1 1
FTO GNPDA2 0 0 805 805 1 1
FTO GAD2 0 0 108 161 1 1
FTO PRKAG3 0 0 174 180 1 1
FTO IGF2 0 0 343 343 1 1
FTO IDH2 0 0 246 245 1 1
FTO NUDT16 0 0 134 159 1 1
FTO PPARGC1B 0 0 385 384 1 1
FTO SRSF3 0 0 347 372 1 1
FTO NPM1 0 0 181 181 1 1
FTO NAMPT 0 0 242 241 1 2
FTO PARVG 0 0 53 255 1 1
FTO SDC3 0 0 414 414 1 1
FTO HHEX 0 0 731 731 1 1
FTO FAM120AOS 0 0 368 368 1 1
FTO UBASH3A 0 0 163 189 1 1
FTO IRX4 0 0 47 158 1 1
FTO RECQL4 270 0 0 270 1 1
FTO FAIM2 0 0 681 687 1 1
FTO OPRD1 0 0 143 174 1 1
FTO EGLN2 0 0 143 223 1 1
FTO GDF5 0 0 194 194 1 1
FTO FFAR4 0 0 608 608 1 1
FTO PRKAA2 0 0 193 201 1 2
FTO AASDHPPT 0 0 0 404 1 1
FTO MAEA 0 0 225 224 1 1
FTO PTEN 0 0 161 234 1 2
FTO DAK 129 0 0 439 1 1
FTO NPY1R 0 0 156 155 1 1
FTO UCP1 0 0 391 390 1 2
FTO SREBF1 0 0 315 315 1 1
FTO ALKBH7 0 0 506 524 1 1
FTO STK33 0 0 150 291 1 1
FTO RASAL2 0 0 244 243 1 1
FTO NXPH1 0 0 181 181 1 1
FTO MC2R 0 0 108 198 1 1
FTO MSH3 0 0 45 194 1 1
FTO ASTN2 0 0 171 328 1 1
FTO LEP 0 0 681 681 1 1
FTO NUP98 0 0 0 168 1 1
FTO HFE 0 0 202 202 1 1
FTO GLE1 0 0 0 216 1 1
FTO PKD2L1 0 0 52 310 1 1
FTO LDHA 129 0 96 178 1 2
FTO TRMT61A 0 0 161 194 1 1
FTO WT1 0 0 159 158 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0043734 Molecular Function DNA-N1-methyladenine dioxygenase activity enables IBA
GO:0043734 Molecular Function DNA-N1-methyladenine dioxygenase activity enables IDA
GO:0008198 Molecular Function ferrous iron binding enables IBA
GO:0008198 Molecular Function ferrous iron binding enables IDA
GO:1990931 Molecular Function mRNA N6-methyladenosine dioxygenase activity enables IBA
GO:1990931 Molecular Function mRNA N6-methyladenosine dioxygenase activity enables IDA
GO:1990931 Molecular Function mRNA N6-methyladenosine dioxygenase activity enables IMP
GO:0035516 Molecular Function oxidative DNA demethylase activity enables IBA
GO:0035516 Molecular Function oxidative DNA demethylase activity enables IDA
GO:0035515 Molecular Function oxidative RNA demethylase activity enables IDA
GO:1990984 Molecular Function tRNA demethylase activity enables IDA
GO:0016740 Molecular Function transferase activity enables IEA
GO:0006307 Biological Process DNA dealkylation involved in DNA repair involved_in IDA
GO:0080111 Biological Process DNA demethylation involved_in IDA
GO:0042245 Biological Process RNA repair involved_in IDA
GO:0060612 Biological Process adipose tissue development involved_in IEA
GO:0061157 Biological Process mRNA destabilization involved_in IDA
GO:0070989 Biological Process oxidative demethylation involved_in IDA
GO:0035552 Biological Process oxidative single-stranded DNA demethylation involved_in IBA
GO:0035552 Biological Process oxidative single-stranded DNA demethylation involved_in IDA
GO:0035553 Biological Process oxidative single-stranded RNA demethylation involved_in IBA
GO:0035553 Biological Process oxidative single-stranded RNA demethylation involved_in IDA
GO:0035553 Biological Process oxidative single-stranded RNA demethylation involved_in IMP
GO:0090335 Biological Process regulation of brown fat cell differentiation involved_in IMP
GO:0010883 Biological Process regulation of lipid storage involved_in IMP
GO:0040014 Biological Process regulation of multicellular organism growth involved_in IEA
GO:0044065 Biological Process regulation of respiratory system process involved_in IEA
GO:0070350 Biological Process regulation of white fat cell proliferation involved_in IEA
GO:0001659 Biological Process temperature homeostasis involved_in IEA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0043231 Cellular Component intracellular membrane-bounded organelle located_in IDA
GO:0016607 Cellular Component nuclear speck located_in IDA
GO:0005654 Cellular Component nucleoplasm located_in TAS
GO:0005634 Cellular Component nucleus located_in IDA
GO:0005634 Cellular Component nucleus located_in ISS
GO:0005886 Cellular Component plasma membrane located_in IDA
Pathways
Name DB ID
DNA Repair Reactome R-HSA-73894
DNA Damage Reversal Reactome R-HSA-73942
Reversal of alkylation damage by DNA dioxygenases Reactome R-HSA-73943
FTO obesity variant mechanism (WP3407) WikiPathways WP3407_r123389
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_156761 1 miscRNA transcript variant 13 NC_000016 Reference
XR_007064911 1 miscRNA transcript variant X12 NC_000016 Reference
NM_001363905 1 mRNA transcript variant 11 NC_000016 Reference
NM_001363891 1 mRNA transcript variant 2 NC_000016 Reference
NM_001363898 1 mRNA transcript variant 6 NC_000016 Reference
NM_001363899 1 mRNA transcript variant 7 NC_000016 Reference
NM_001363894 1 mRNA transcript variant 1 NC_000016 Reference
NM_001363988 1 mRNA transcript variant 12 NC_000016 Reference
NM_001363896 1 mRNA transcript variant 4 NC_000016 Reference
NM_001363903 1 mRNA transcript variant 10 NC_000016 Reference
NM_001363900 1 mRNA transcript variant 8 NC_000016 Reference
NM_001363901 1 mRNA transcript variant 9 NC_000016 Reference
NM_001363897 1 mRNA transcript variant 5 NC_000016 Reference
XM_047434606 1 mRNA transcript variant X2 NC_000016 Reference
XM_047434607 1 mRNA transcript variant X3 NC_000016 Reference
XM_011523314 4 mRNA transcript variant X4 NC_000016 Reference
XM_011523316 4 mRNA transcript variant X7 NC_000016 Reference
XM_017023656 3 mRNA transcript variant X8 NC_000016 Reference
XM_024450437 2 mRNA transcript variant X11 NC_000016 Reference
XM_017023654 3 mRNA transcript variant X1 NC_000016 Reference
XM_011523315 4 mRNA transcript variant X5 NC_000016 Reference
XM_047434608 1 mRNA transcript variant X6 NC_000016 Reference
XM_017023657 3 mRNA transcript variant X9 NC_000016 Reference
XM_047434609 1 mRNA transcript variant X10 NC_000016 Reference
NM_001080432 3 mRNA transcript variant 3 NC_000016 Reference