HAdb 2.0 is available now!

TFEB

transcription factor EB
General Information
Name transcription factor EB
Alias
  • transcription factor EB
  • T-cell transcription factor EB
  • class E basic helix-loop-helix protein 35
Gene_family Basic helix-loop-helix proteins
organism Homo sapiens
entrez_id 7942
location 6p21.1
transcript_count 8
exon_count 15
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Enables DNA-binding transcription factor activity; enzyme binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to amino acid starvation; lysosome localization; and positive regulation of autophagy. Located in cytosol; lysosomal membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Stringdb Transcription factor EB; Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate the [...]
    nextProt Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:30120233, PubMed:31672913, PubMed:35662396). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:35662396). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:35662396). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
TFEB BioGRID DDA1 GeneID BioGRID Proximity Label-MS
TFEB BioGRID RRAGC GeneID BioGRID Affinity Capture-Western
TFEB BioGRID ATG16L1 GeneID BioGRID Proximity Label-MS
TFEB BioGRID RRAGA GeneID BioGRID Affinity Capture-Western
TFEB BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA
TFEB BioGRID FOXO1 GeneID BioGRID Proximity Label-MS
TFEB BioGRID YWHAE GeneID BioGRID Affinity Capture-MS
TFEB BioGRID ANXA2 GeneID BioGRID Affinity Capture-Western
TFEB BioGRID PGAM4 GeneID BioGRID Affinity Capture-MS
TFEB BioGRID TFEC GeneID BioGRID Affinity Capture-MS
TFEB BioGRID YWHAQ GeneID BioGRID Affinity Capture-MS
TFEB BioGRID YWHAZ GeneID BioGRID Affinity Capture-MS
TFEB BioGRID YWHAH GeneID BioGRID Affinity Capture-MS
TFEB BioGRID YWHAG GeneID BioGRID Affinity Capture-MS
TFEB BioGRID YWHAB GeneID BioGRID Affinity Capture-MS
TFEB BioGRID TFE3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
TFEB BioGRID TAF9 GeneID BioGRID Affinity Capture-MS
TFEB BioGRID MITF GeneID BioGRID Affinity Capture-MS
TFEB BioGRID NHLRC2 GeneID BioGRID Proximity Label-MS
TFEB BioGRID H4C1 GeneID BioGRID Affinity Capture-MS
TFEB BioGRID TFEB GeneID BioGRID Affinity Capture-Western
TFEB BioGRID STUB1 GeneID BioGRID Affinity Capture-Western
TFEB BioGRID TRIM16 GeneID BioGRID Affinity Capture-Western
TFEB BioGRID GPNMB GeneID BioGRID Affinity Capture-MS
TFEB BioGRID LCOR GeneID BioGRID Affinity Capture-MS
TFEB BioGRID HDAC5 GeneID BioGRID Affinity Capture-Western
TFEB BioGRID BAG2 GeneID BioGRID Affinity Capture-MS
TFEB BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
TFEB BioGRID PPM1G GeneID BioGRID Affinity Capture-MS
TFEB BioGRID MAPT GeneID BioGRID Affinity Capture-MS
TFEB BioGRID STT3A GeneID BioGRID Affinity Capture-MS
TFEB BioGRID IFIT1 GeneID BioGRID Affinity Capture-MS
TFEB BioGRID ATP5PF GeneID BioGRID Affinity Capture-MS
TFEB BioGRID TBC1D14 GeneID BioGRID Affinity Capture-MS
TFEB BioGRID EML4 GeneID BioGRID Affinity Capture-MS
TFEB BioGRID MCAT GeneID BioGRID Affinity Capture-MS
TFEB BioGRID SRPK1 GeneID BioGRID Biochemical Activity
TFEB Protein TFEC GeneID HPRD
TFEB Protein TFE3 GeneID HPRD
TFEB Protein MITF GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
TFEB RANBP17 0 0 87 245 1 1
TFEB LIPE 0 0 240 256 1 1
TFEB MFN2 0 0 302 342 1 2
TFEB APP 0 0 419 424 1 2
TFEB ARL8A 0 0 0 175 1 1
TFEB OSTM1 0 0 310 320 1 1
TFEB CTNNB1 0 0 217 217 1 2
TFEB MAP1LC3A 0 0 519 649 1 2
TFEB HRAS 0 0 206 258 1 2
TFEB XPO1 0 0 509 594 1 1
TFEB ARL1 0 0 0 151 1 1
TFEB RAB5A 0 0 323 337 1 2
TFEB IL1B 0 0 294 307 1 2
TFEB NR1H3 0 0 108 167 1 1
TFEB HIF1A 0 0 390 438 1 2
TFEB ATP6V1H 0 0 414 495 1 1
TFEB SIRT5 0 0 230 252 1 1
TFEB BAG3 0 0 310 347 1 2
TFEB PRKCB 0 0 294 302 1 2
TFEB NDUFS4 0 0 108 169 1 1
TFEB CTSL 0 0 414 431 1 2
TFEB SLC1A7 0 0 250 255 1 1
TFEB CLN3 0 0 392 438 1 2
TFEB ID1 0 0 0 202 1 1
TFEB IL6 0 0 234 234 1 2
TFEB NFYB 0 0 0 156 1 1
TFEB CTRL 0 0 150 169 1 2
TFEB CHMP2B 0 0 292 300 1 2
TFEB PIK3C3 0 0 602 626 1 2
TFEB UCP2 0 0 138 156 1 2
TFEB PLEK 0 0 125 167 1 1
TFEB TBX2 0 0 71 411 1 1
TFEB RPS6 0 0 323 323 1 2
TFEB ENSG00000115239 0 0 70 182 1 1
TFEB TRIM37 0 0 134 282 1 1
TFEB STAT1 0 0 129 173 1 2
TFEB H3F3A 0 0 66 228 1 1
TFEB FOXO6 0 0 90 162 1 1
TFEB COG6 0 0 98 211 1 1
TFEB NOTCH1 0 0 181 181 1 2
TFEB PSEN2 0 0 207 207 1 1
TFEB HIST1H4F 270 0 105 393 1 1
TFEB SORT1 0 0 231 352 1 1
TFEB MTMR3 0 0 91 289 1 2
TFEB MED15 0 0 203 220 1 1
TFEB POTEF 0 0 234 266 1 1
TFEB KPNA1 0 0 154 153 1 1
TFEB ANKRD13D 0 0 137 200 1 1
TFEB TBR1 0 0 0 151 1 1
TFEB GLA 0 0 248 248 1 2
TFEB MAPKAP1 0 0 112 200 1 1
TFEB SYT7 0 0 274 437 1 1
TFEB MTOR 0 0 733 754 1 2
TFEB LAMTOR5 0 0 224 224 1 1
TFEB SLC38A9 0 0 460 467 1 1
TFEB ATP13A1 0 0 0 200 1 1
TFEB FBXO32 0 0 166 199 1 2
TFEB FGF21 0 0 282 282 1 2
TFEB ANXA5 0 0 150 203 1 2
TFEB CS 0 0 122 234 1 1
TFEB HSF1 0 0 81 158 1 2
TFEB ZKSCAN3 0 0 680 691 1 2
TFEB C12orf66 0 0 134 168 1 1
TFEB RGS4 0 0 56 156 1 1
TFEB DIAPH1 0 0 416 416 1 1
TFEB PSAP 0 0 335 494 1 1
TFEB SIRT2 0 0 217 243 1 2
TFEB SCAP 0 0 75 174 1 1
TFEB CREBBP 0 0 113 151 1 1
TFEB TPCN2 0 0 370 401 1 1
TFEB ARF1 0 0 134 202 1 1
TFEB GRB10 0 0 276 287 1 1
TFEB SDHB 0 0 246 245 1 1
TFEB ESRRA 0 0 212 314 1 1
TFEB HCST 0 0 0 159 1 1
TFEB CREB1 0 0 296 296 1 2
TFEB FGF14 0 0 0 433 1 1
TFEB IFNG 0 0 97 156 1 2
TFEB RAPGEF3 0 0 92 249 1 1
TFEB LMAN2 0 0 67 276 1 1
TFEB GAPDH 0 0 425 435 1 2
TFEB ATG14 0 0 556 583 1 2
TFEB LARS2 0 0 243 375 1 1
TFEB TLR4 0 0 206 229 1 2
TFEB MAP2K7 0 0 166 165 1 1
TFEB MAP6 0 0 112 167 1 1
TFEB HIST4H4 0 0 105 203 1 1
TFEB JAG2 0 0 326 325 1 1
TFEB APOA1 0 0 150 203 1 1
TFEB ARL5B 0 0 207 241 1 1
TFEB GABARAPL2 0 0 505 527 1 2
TFEB HDAC10 0 0 90 150 1 1
TFEB KHDRBS2 0 0 510 521 1 1
TFEB PRR5 0 0 297 323 1 1
TFEB PHLPP1 0 0 122 184 1 2
TFEB SH2D1B 0 0 216 216 1 1
TFEB PIK3R4 0 0 425 433 1 2
TFEB ACSS2 0 0 954 954 1 1
TFEB CARM1 0 0 726 732 1 2
TFEB FYCO1 0 0 290 290 1 2
TFEB TPCN1 0 0 225 251 1 1
TFEB RELA 0 0 125 161 1 2
TFEB BCL2L1 0 0 173 173 1 2
TFEB LIPM 0 0 459 462 1 1
TFEB TBX5 0 0 0 151 1 1
TFEB NPC1 0 0 391 390 1 2
TFEB GALNS 0 0 194 233 1 1
TFEB GLIPR2 0 0 134 225 1 2
TFEB PPP3CB 270 0 270 503 1 1
TFEB ATP6V1G1 0 0 54 175 1 1
TFEB YTHDF2 0 0 123 195 1 1
TFEB PNN 0 0 74 215 1 1
TFEB ENSG00000261832 0 0 391 437 1 1
TFEB RICTOR 0 0 359 398 1 2
TFEB ACP5 0 0 124 235 1 1
TFEB PIK3CA 0 0 82 154 1 2
TFEB VAPA 0 0 107 157 1 1
TFEB SYT11 0 0 116 171 1 1
TFEB PARK2 0 0 457 496 1 1
TFEB PGA5 0 0 0 290 1 1
TFEB IL18 0 0 154 153 1 2
TFEB CLOCK 0 0 432 493 1 2
TFEB ARL8B 0 0 261 367 1 1
TFEB GNS 0 0 243 321 1 1
TFEB MYC 0 0 310 391 1 2
TFEB IRGM 0 0 279 279 1 2
TFEB BLOC1S1 0 0 361 367 1 1
TFEB PPARGC1A 0 0 659 664 1 2
TFEB IGF1R 0 0 112 158 1 2
TFEB ATP6V1G3 0 0 0 163 1 1
TFEB SDHC 0 0 203 203 1 1
TFEB TCERG1 0 0 150 212 1 1
TFEB SCARB2 0 0 390 398 1 1
TFEB USF1 0 0 212 213 1 1
TFEB ENSG00000272772 0 0 0 374 1 1
TFEB B3GALT4 0 0 57 166 1 1
TFEB RB1CC1 0 0 557 569 1 2
TFEB NFE2L2 0 0 323 342 1 2
TFEB MFF 0 0 143 169 1 1
TFEB STK11 0 0 298 329 1 2
TFEB CIDEB 0 0 294 294 1 1
TFEB CTSE 0 0 113 316 1 1
TFEB HDAC5 270 0 125 377 1 1
TFEB L3MBTL4 0 0 0 189 1 1
TFEB TFEC 363 0 858 440 1 1
TFEB MEF2D 0 0 181 236 1 2
TFEB C9orf72 0 0 379 379 1 2
TFEB HIST1H4L 0 0 105 203 1 1
TFEB MYCN 0 0 81 240 1 1
TFEB ACTA1 0 0 103 209 1 1
TFEB EFNA5 0 0 899 899 1 1
TFEB PARK7 0 0 233 239 1 2
TFEB FXN 0 0 60 158 1 1
TFEB NGDN 0 0 190 190 1 1
TFEB TAX1BP1 0 0 218 297 1 2
TFEB PIFO 0 0 76 421 1 1
TFEB VPS39 0 0 181 181 1 1
TFEB OEBT 0 0 211 243 1 1
TFEB HK2 0 0 160 165 1 2
TFEB DOK3 0 0 0 163 1 1
TFEB MXD4 0 0 49 161 1 1
TFEB ENSG00000124593 0 0 211 243 1 1
TFEB SNAP23 0 0 156 155 1 1
TFEB LMNA 0 0 193 210 1 2
TFEB NCOR2 0 0 0 267 1 1
TFEB C1orf85 0 0 284 299 1 1
TFEB RAB10 0 0 284 284 1 1
TFEB SUMF1 0 0 261 307 1 1
TFEB ORAI1 0 0 161 180 1 1
TFEB MAP1A 0 0 406 406 1 2
TFEB LIPN 0 0 380 409 1 1
TFEB SLC7A5 0 0 166 197 1 1
TFEB CTSA 0 0 406 455 1 1
TFEB HDAC2 0 0 136 167 1 1
TFEB DDIT3 0 0 208 257 1 2
TFEB ENSG00000273637 0 0 0 204 1 1
TFEB NR1H2 0 0 108 164 1 1
TFEB NAT6 0 0 321 321 1 1
TFEB ATP6V0C 0 0 173 200 1 1
TFEB GAA 0 0 177 195 1 2
TFEB TRIM16 270 0 286 456 1 2
TFEB MAOA 0 0 134 170 1 1
TFEB GART 0 0 0 288 1 1
TFEB TP53 0 0 372 426 1 2
TFEB HTT 0 0 504 523 1 2
TFEB EGFR 0 0 218 218 1 2
TFEB HIST1H4I 0 0 105 203 1 1
TFEB PSTPIP1 0 0 0 151 1 1
TFEB LAMP1 0 0 702 818 1 2
TFEB SLC2A1 0 0 204 253 1 2
TFEB AHSA2 0 0 0 177 1 1
TFEB TFAP4 0 0 102 194 1 1
TFEB MCOLN1 0 0 756 801 1 2
TFEB LAMTOR4 0 0 320 384 1 1
TFEB RAB8A 0 0 179 179 1 2
TFEB UBR5 0 0 67 154 1 1
TFEB OCRL 0 0 155 213 1 1
TFEB INPP5E 0 0 82 158 1 1
TFEB SFPQ 0 0 369 369 1 1
TFEB CENPA 0 0 0 207 1 1
TFEB ERN1 0 0 209 232 1 2
TFEB ATP6V0D1 0 0 229 363 1 1
TFEB C7orf60 0 0 146 157 1 1
TFEB NCOA1 0 0 0 175 1 1
TFEB CD300C 0 0 392 414 1 1
TFEB STAT3 0 0 424 453 1 2
TFEB POU5F1B 0 0 0 179 1 1
TFEB EIF2AK4 0 0 231 265 1 2
TFEB HDAC6 0 0 303 329 1 2
TFEB VAMP8 0 0 288 288 1 2
TFEB LY86 0 0 0 160 1 1
TFEB NPRL2 0 0 212 258 1 1
TFEB FGR 0 0 0 171 1 1
TFEB BRD4 0 0 150 180 1 2
TFEB CAMKK2 0 0 294 317 1 2
TFEB MYBL1 0 0 0 155 1 1
TFEB AUP1 0 0 143 162 1 1
TFEB HIST2H3D 0 0 0 207 1 1
TFEB ARSG 0 0 112 167 1 1
TFEB IL4 0 0 107 205 1 1
TFEB EP300 0 0 148 196 1 2
TFEB LGALS8 0 0 194 194 1 1
TFEB CDK5 0 0 123 165 1 2
TFEB UBE2QL1 0 0 180 187 1 1
TFEB MADD 0 0 319 319 1 1
TFEB SMAD3 0 0 454 454 1 2
TFEB PPM1G 211 0 0 238 1 1
TFEB ALB 0 0 310 360 1 2
TFEB CD68 0 0 181 364 1 2
TFEB SORCS3 0 0 108 163 1 1
TFEB CCL2 0 0 135 150 1 2
TFEB TYROBP 0 0 67 166 1 1
TFEB MME 0 0 293 293 1 1
TFEB CTNS 0 0 294 294 1 2
TFEB PGK1 0 0 103 159 1 2
TFEB KAT2A 0 0 72 225 1 1
TFEB GLB1 0 0 164 163 1 1
TFEB ATG16L2 0 0 193 234 1 2
TFEB ZNF765 0 0 164 194 1 1
TFEB SLC3A2 0 0 145 186 1 1
TFEB GATA1 0 0 113 190 1 1
TFEB H3F3B 0 0 53 217 1 1
TFEB ALK 0 0 161 174 1 2
TFEB ABCA1 0 0 159 158 1 2
TFEB DCTN1 0 0 195 195 1 1
TFEB DNM2 0 0 116 153 1 1
TFEB COL21A1 0 0 241 240 1 1
TFEB MAP1LC3C 0 0 261 294 1 2
TFEB SIRT6 0 0 223 241 1 2
TFEB HLF 0 0 535 553 1 1
TFEB YWHAG 818 0 60 830 1 1
TFEB HIST1H4E 0 0 105 203 1 1
TFEB CDH1 0 0 173 173 1 2
TFEB OSGIN1 0 0 447 447 1 1
TFEB BCL2L13 0 0 161 161 1 2
TFEB VPS35 0 0 233 291 1 2
TFEB MIOS 0 0 193 193 1 1
TFEB MLXIPL 0 0 203 381 1 1
TFEB MAPK8 0 0 171 177 1 2
TFEB SKP2 0 0 297 297 1 2
TFEB AKNA 0 0 142 176 1 1
TFEB EIF2S2 0 0 0 196 1 1
TFEB PEX5 0 0 181 216 1 1
TFEB LAMP5 0 0 0 236 1 1
TFEB TBX3 0 0 0 266 1 1
TFEB VPS33A 0 0 171 184 1 1
TFEB GIF 0 0 0 211 1 1
TFEB LILRB2 0 0 0 158 1 1
TFEB ATP6V0D2 0 0 265 542 1 1
TFEB SESN2 0 0 335 390 1 2
TFEB HIST2H3PS2 0 0 319 437 1 1
TFEB VPS18 0 0 395 432 1 1
TFEB KCTD7 0 0 134 330 1 1
TFEB FKBP1A 0 0 242 241 1 2
TFEB SRPK1 289 0 0 318 1 1
TFEB SMARCB1 0 0 203 220 1 1
TFEB RPS6KB2 0 0 113 168 1 2
TFEB ATP6AP2 0 0 113 181 1 1
TFEB CLTC 0 0 391 390 1 1
TFEB CTSH 0 0 108 218 1 1
TFEB TYR 0 0 181 279 1 2
TFEB SEPT9 0 0 0 403 1 1
TFEB GATA4 0 0 70 151 1 2
TFEB HSPA4 0 0 193 193 1 1
TFEB PPARA 0 0 501 523 1 2
TFEB SKIDA1 0 0 0 161 1 1
TFEB RPTOR 0 0 738 774 1 2
TFEB CEBPD 0 0 90 150 1 1
TFEB ATP6V1D 0 0 174 184 1 1
TFEB SERINC5 0 0 102 200 1 1
TFEB CYCS 0 0 267 342 1 2
TFEB SRRT 0 0 296 296 1 1
TFEB ACP2 0 0 182 203 1 1
TFEB FLCN 0 0 601 649 1 1
TFEB TREH 0 0 258 258 1 1
TFEB SOX30 0 0 0 162 1 1
TFEB ITPR1 0 0 167 167 1 2
TFEB TBC1D15 0 0 163 177 1 1
TFEB ATG4A 0 0 161 193 1 2
TFEB MLXIP 0 0 181 364 1 1
TFEB SORCS2 0 0 66 161 1 1
TFEB HGSNAT 0 0 150 203 1 1
TFEB SH3GLB1 0 0 195 195 1 2
TFEB EGF 0 0 201 205 1 2
TFEB ZSCAN25 0 0 120 205 1 1
TFEB LIPJ 0 0 457 460 1 1
TFEB GM2A 0 0 209 230 1 1
TFEB CASP1 0 0 231 268 1 2
TFEB NCOA2 0 0 46 170 1 1
TFEB AKT1S1 0 0 373 386 1 1
TFEB SGSH 0 0 322 365 1 1
TFEB CD27 0 0 0 151 1 1
TFEB SNAP29 0 0 280 295 1 2
TFEB NPC2 0 0 298 298 1 1
TFEB SNCA 0 0 666 683 1 2
TFEB ULK2 0 0 455 494 1 2
TFEB ZFP36 0 0 57 196 1 1
TFEB SERINC3 0 0 101 249 1 1
TFEB SRF 0 0 0 189 1 1
TFEB AIF1 0 0 201 215 1 2
TFEB TBX20 0 0 0 154 1 1
TFEB NRF1 0 0 185 185 1 2
TFEB S1PR4 0 0 0 161 1 1
TFEB TPP1 0 0 325 351 1 1
TFEB SI 0 0 289 290 1 1
TFEB SERPINA1 0 0 232 231 1 2
TFEB SNX1 0 0 82 171 1 1
TFEB TSC1 0 0 390 435 1 2
TFEB DENND3 0 0 103 150 1 2
TFEB ITPR3 0 0 165 165 1 1
TFEB JUN 0 0 203 283 1 2
TFEB RHOT1 0 0 123 213 1 1
TFEB CAPN2 0 0 134 161 1 2
TFEB YWHAE 645 0 0 666 1 1
TFEB VCP 0 0 260 289 1 2
TFEB LAMP2 0 0 634 725 1 2
TFEB ARL10 0 0 0 151 1 1
TFEB CTSF 0 0 391 482 1 1
TFEB H3F3C 0 0 0 207 1 1
TFEB GOLGA2 0 0 120 175 1 1
TFEB GRN 0 0 536 555 1 1
TFEB MAX 0 0 42 155 1 2
TFEB NPRL3 0 0 193 210 1 1
TFEB RILP 0 0 194 214 1 1
TFEB LAMP3 0 0 0 236 1 1
TFEB ARNT 0 0 95 429 1 2
TFEB ENPP6 0 0 112 167 1 1
TFEB MNT 0 0 92 199 1 1
TFEB MIB2 0 0 72 165 1 1
TFEB TBC1D4 0 0 46 185 1 1
TFEB SOD1 0 0 310 309 1 2
TFEB CD8A 0 0 157 156 1 1
TFEB MCOLN2 0 0 396 449 1 1
TFEB DEPDC5 0 0 211 227 1 1
TFEB FUNDC1 0 0 325 325 1 2
TFEB RAB27A 0 0 162 161 1 1
TFEB MFN1 0 0 248 292 1 2
TFEB MCOLN3 0 0 422 481 1 1
TFEB CREB3 0 0 144 162 1 1
TFEB HIST2H3C 0 0 0 207 1 1
TFEB TREM2 0 0 143 182 1 1
TFEB NCOA3 0 0 60 169 1 1
TFEB TCIRG1 0 0 125 195 1 1
TFEB TFAM 0 0 374 391 1 2
TFEB ARSA 0 0 123 201 1 2
TFEB VSX2 0 0 0 150 1 1
TFEB ATG9A 0 0 464 508 1 2
TFEB SOX21 0 0 0 162 1 1
TFEB RAB24 0 0 194 210 1 2
TFEB ZNF746 0 0 202 388 1 1
TFEB NKRF 0 0 180 209 1 1
TFEB GATSL3 0 0 260 276 1 1
TFEB CDKN1A 0 0 307 307 1 2
TFEB EIF4G1 0 0 141 164 1 2
TFEB AR 0 0 272 289 1 2
TFEB HIST1H3D 0 0 0 207 1 1
TFEB ABTB1 0 0 0 150 1 1
TFEB HSPA8 0 0 406 406 1 2
TFEB CRTC2 0 0 294 328 1 1
TFEB SYN1 0 0 124 156 1 1
TFEB TARDBP 0 0 408 408 1 2
TFEB GABPB1 0 0 143 156 1 1
TFEB MLKL 0 0 125 158 1 2
TFEB RAB1A 0 0 232 237 1 1
TFEB PLEKHF2 0 0 210 210 1 1
TFEB TMEM175 0 0 162 182 1 1
TFEB RAB35 0 0 139 177 1 1
TFEB MXI1 0 0 108 213 1 1
TFEB SIRT7 0 0 218 253 1 2
TFEB MID1 0 0 54 154 1 1
TFEB FOXA3 0 0 0 152 1 1
TFEB GABARAPL1 0 0 548 568 1 2
TFEB VPS16 0 0 204 301 1 1
TFEB UNC93B1 0 0 46 161 1 1
TFEB ATP6V1E1 0 0 70 162 1 1
TFEB PAX8 0 0 387 396 1 1
TFEB HSP90AA1 0 0 210 290 1 2
TFEB PNPLA2 0 0 297 325 1 2
TFEB BACE2 0 0 103 348 1 1
TFEB HPGDS 0 0 228 228 1 1
TFEB CEBPA 0 0 143 214 1 1
TFEB SOX2 0 0 123 263 1 2
TFEB COX4I1 0 0 293 308 1 1
TFEB UGCG 0 0 194 194 1 1
TFEB PSEN1 0 0 450 454 1 2
TFEB MUL1 0 0 149 243 1 2
TFEB RAB29 0 0 142 222 1 1
TFEB FOXG1 0 0 52 182 1 1
TFEB MXD3 0 0 0 154 1 1
TFEB ATG13 0 0 609 647 1 2
TFEB INS 0 0 393 392 1 2
TFEB ACTB 0 0 451 474 1 2
TFEB SNX10 0 0 171 202 1 2
TFEB STUB1 270 0 295 463 1 2
TFEB ATP6V1G2 0 0 0 163 1 1
TFEB SIRT3 0 0 273 297 1 2
TFEB PNPLA5 0 0 167 172 1 1
TFEB KEAP1 0 0 294 309 1 2
TFEB MAPK3 0 0 236 260 1 2
TFEB SQSTM1 0 0 735 757 1 2
TFEB BNIP3 0 0 612 612 1 2
TFEB HIST1H4J 0 0 105 203 1 1
TFEB JUNB 0 0 0 164 1 1
TFEB SIM2 0 0 74 160 1 1
TFEB DPP7 0 0 95 155 1 1
TFEB IFIT1 135 0 60 194 1 1
TFEB RIPK3 0 0 180 289 1 2
TFEB ZFYVE1 0 0 305 443 1 2
TFEB PGA3 0 0 0 290 1 1
TFEB PRKCD 0 0 118 151 1 2
TFEB TGOLN2 0 0 108 181 1 1
TFEB VAMP7 0 0 256 397 1 2
TFEB ABCD3 0 0 171 171 1 1
TFEB SLC30A2 0 0 146 234 1 1
TFEB CLCN7 0 0 426 430 1 1
TFEB MAF1 0 0 113 156 1 1
TFEB BNIP3L 0 0 401 402 1 2
TFEB VDAC1 0 0 235 235 1 2
TFEB RAB7B 0 0 525 537 1 1
TFEB TSC2 0 0 544 586 1 2
TFEB RAC2 0 0 150 262 1 1
TFEB RAB11A 0 0 246 279 1 2
TFEB TOMM20 0 0 264 264 1 2
TFEB YY1 0 0 207 235 1 1
TFEB STX17 0 0 401 435 1 2
TFEB LYST 0 0 88 193 1 1
TFEB KDR 0 0 83 180 1 2
TFEB RRAGA 0 0 556 604 1 1
TFEB MITF 831 800 736 967 1 2
TFEB EIF2S1 0 0 233 232 1 2
TFEB SKP1 0 0 73 332 1 2
TFEB NRBF2 0 0 245 246 1 2
TFEB HMOX1 0 0 326 325 1 2
TFEB RGS19 0 0 74 158 1 2
TFEB CLN8 0 0 135 263 1 1
TFEB MTFP1 0 0 151 204 1 1
TFEB LAPTM4B 0 0 154 169 1 2
TFEB SORCS1 0 0 106 161 1 1
TFEB HIST1H4D 0 0 105 203 1 1
TFEB ATG2B 0 0 225 259 1 2
TFEB SEC13 0 0 159 158 1 1
TFEB TBK1 0 0 285 356 1 2
TFEB TBX4 0 0 0 151 1 1
TFEB EIF2AK3 0 0 212 212 1 2
TFEB HNF4A 0 0 195 280 1 1
TFEB LGALS3 0 0 193 239 1 2
TFEB ATG3 0 0 501 509 1 2
TFEB HEXA 0 0 375 426 1 1
TFEB NAGLU 0 0 358 446 1 1
TFEB SIM1 0 0 82 173 1 1
TFEB TXNDC9 0 0 698 702 1 1
TFEB BLOC1S6 0 0 82 420 1 1
TFEB SCD 0 0 141 166 1 1
TFEB SRC 0 0 150 164 1 2
TFEB ATG4C 0 0 218 242 1 2
TFEB CDC42 0 0 124 177 1 2
TFEB PQLC2 0 0 160 160 1 1
TFEB FAM117A 0 0 142 199 1 1
TFEB EEA1 0 0 259 272 1 2
TFEB TNFSF11 0 0 153 152 1 2
TFEB WDR24 0 0 215 238 1 1
TFEB GRIPAP1 0 0 234 234 1 1
TFEB DNAJC5 0 0 211 290 1 1
TFEB SLC2A4 0 0 166 235 1 1
TFEB METTL3 0 0 166 204 1 2
TFEB FOXO3 0 0 504 543 1 2
TFEB YWHAB 818 0 0 827 1 1
TFEB APOE 0 0 244 260 1 2
TFEB CADM2 0 0 233 232 1 1
TFEB HIST1H3G 0 0 0 207 1 1
TFEB IRF3 0 0 138 156 1 2
TFEB NGF 0 0 73 171 1 2
TFEB TH 0 0 183 183 1 2
TFEB CTSC 0 0 138 267 1 1
TFEB TMEM163 0 0 164 251 1 1
TFEB AHSA1 0 0 0 177 1 1
TFEB IGF2R 0 0 211 211 1 1
TFEB MGAM 0 0 287 299 1 1
TFEB ATP6V1A 0 0 334 440 1 1
TFEB TLR9 0 0 140 166 1 2
TFEB SPRTN 0 0 61 192 1 1
TFEB IPO8 0 0 253 279 1 1
TFEB FOXO4 0 0 113 224 1 1
TFEB TOR4A 0 0 141 299 1 1
TFEB PIKFYVE 0 0 400 421 1 2
TFEB EIF4EBP1 0 0 518 542 1 2
TFEB ID2 0 0 62 219 1 1
TFEB PPP3CA 0 0 87 155 1 1
TFEB SIRT4 0 0 244 261 1 1
TFEB UBQLN1 0 0 107 175 1 1
TFEB PINK1 0 0 519 558 1 2
TFEB SDHD 0 0 204 204 1 1
TFEB HAUS5 0 0 0 177 1 1
TFEB MTMR4 0 0 66 193 1 1
TFEB CEBPG 0 0 57 201 1 1
TFEB VMP1 0 0 170 169 1 2
TFEB PARL 0 0 180 202 1 1
TFEB PPP2R4 0 0 167 167 1 1
TFEB ENSG00000144785 0 0 0 164 1 1
TFEB SLC36A1 0 0 158 176 1 1
TFEB SLC38A7 0 0 216 233 1 1
TFEB KLF4 0 0 134 201 1 2
TFEB ATF6 0 0 206 217 1 2
TFEB FOXA1 0 0 0 152 1 1
TFEB IFIT3 0 0 45 156 1 1
TFEB ATF1 0 0 181 181 1 1
TFEB CD4 0 0 138 163 1 2
TFEB CA9 0 0 324 323 1 1
TFEB MXD1 0 0 0 154 1 1
TFEB ATF4 0 0 325 325 1 2
TFEB HIST1H4C 0 0 105 203 1 1
TFEB RASD2 0 0 162 214 1 1
TFEB PPARG 0 0 350 365 1 2
TFEB AKT1 0 0 504 523 1 2
TFEB SPIB 0 0 399 399 1 1
TFEB ETF1 0 0 45 219 1 1
TFEB FAM98C 0 0 218 218 1 1
TFEB SEPT12 0 0 0 208 1 1
TFEB C17orf59 0 0 181 181 1 1
TFEB RBFOX3 0 0 143 162 1 1
TFEB PAX3 0 0 306 316 1 1
TFEB FNIP2 0 0 418 476 1 1
TFEB POU2F1 0 0 384 402 1 1
TFEB IGBP1 0 0 45 158 1 1
TFEB ATP13A2 0 0 325 353 1 1
TFEB TMEM147 0 0 0 187 1 1
TFEB RCAN1 0 0 134 157 1 2
TFEB FIS1 0 0 261 261 1 2
TFEB WIPI2 0 0 455 558 1 2
TFEB NAA35 0 0 0 161 1 1
TFEB SLC1A5 0 0 139 192 1 1
TFEB BDNF 0 0 156 155 1 2
TFEB DCT 0 0 396 397 1 1
TFEB ZFP36L2 0 0 0 161 1 1
TFEB ARNT2 0 0 0 413 1 1
TFEB MLX 0 0 142 173 1 1
TFEB LUC7L3 0 0 285 284 1 1
TFEB VDR 0 0 81 193 1 2
TFEB NBR1 0 0 492 514 1 2
TFEB TNF 0 0 243 265 1 2
TFEB RSC1A1 0 0 0 208 1 1
TFEB LARS 0 0 283 403 1 1
TFEB VPS11 0 0 414 478 1 1
TFEB WDFY3 0 0 282 292 1 2
TFEB TBX18 0 0 0 154 1 1
TFEB APOL1 0 0 204 204 1 2
TFEB CSF1R 0 0 81 191 1 1
TFEB UVRAG 0 0 602 640 1 2
TFEB HIST1H3H 0 0 0 207 1 1
TFEB IRF7 0 0 112 166 1 1
TFEB MAPK1 0 0 392 415 1 2
TFEB IGF1 0 0 261 261 1 2
TFEB ARNTL 0 0 84 183 1 1
TFEB RAB39A 0 0 49 185 1 1
TFEB WDR45 0 0 261 274 1 2
TFEB GCM1 0 0 203 238 1 1
TFEB CCND3 0 0 98 160 1 1
TFEB CIC 0 0 59 166 1 1
TFEB ESRRB 0 0 60 232 1 1
TFEB TMEM55A 0 0 128 380 1 1
TFEB ZNF451 0 0 56 183 1 1
TFEB FOXK2 0 0 113 183 1 1
TFEB DRAM1 0 0 283 297 1 2
TFEB RAB7A 0 0 556 572 1 2
TFEB TXNIP 0 0 157 175 1 2
TFEB LAMTOR2 0 0 282 318 1 1
TFEB GPNMB 129 0 193 312 1 1
TFEB TFRC 0 0 134 197 1 1
TFEB CCND2 0 0 54 154 1 1
TFEB HIST1H4H 0 0 105 203 1 1
TFEB ACMSD 0 0 54 294 1 1
TFEB CD63 0 0 218 227 1 2
TFEB AGT 0 0 0 293 1 1
TFEB LAMTOR3 0 0 233 232 1 1
TFEB ATP12A 0 0 392 405 1 1
TFEB GCG 0 0 150 208 1 1
TFEB ATG4B 0 0 401 418 1 2
TFEB HSF2 0 0 74 152 1 1
TFEB SREBF2 0 0 269 222 1 1
TFEB PRKAA1 0 0 212 242 1 2
TFEB GPR143 0 0 436 456 1 1
TFEB FRS3 0 0 210 705 1 1
TFEB ARL16 0 0 0 151 1 1
TFEB ULK3 0 0 101 166 1 2
TFEB HEXB 0 0 291 374 1 1
TFEB NOS3 0 0 119 150 1 2
TFEB PTAFR 0 0 0 172 1 1
TFEB STIM1 0 0 210 210 1 2
TFEB DVL2 0 0 154 186 1 2
TFEB EPG5 0 0 349 354 1 2
TFEB IPMK 0 0 123 160 1 1
TFEB LIPA 0 0 467 470 1 1
TFEB SESN1 0 0 171 185 1 1
TFEB IRS1 0 0 233 237 1 2
TFEB MGA 0 0 0 151 1 1
TFEB SGK1 0 0 280 339 1 2
TFEB YWHAQ 270 0 93 343 1 1
TFEB KAT2B 0 0 76 203 1 1
TFEB DMTF1 0 0 0 188 1 1
TFEB REM1 0 0 75 170 1 1
TFEB PGC 0 0 150 383 1 1
TFEB RPS6KB1 0 0 560 587 1 2
TFEB SPG11 0 0 134 176 1 1
TFEB IDUA 0 0 229 252 1 1
TFEB HIST1H4B 0 0 105 203 1 1
TFEB LYL1 0 0 64 171 1 1
TFEB NCOR1 0 0 150 470 1 1
TFEB EIF4E 0 0 252 269 1 2
TFEB NDC80 0 0 0 208 1 1
TFEB CAT 0 0 219 219 1 2
TFEB ATP5J 275 0 0 275 1 1
TFEB TBX1 0 0 0 154 1 1
TFEB ATG2A 0 0 181 217 1 2
TFEB CANX 0 0 181 181 1 2
TFEB HIST1H3F 0 0 0 207 1 1
TFEB NUTM1 0 0 174 173 1 1
TFEB DDI2 0 0 96 253 1 1
TFEB FH 0 0 304 304 1 1
TFEB SLC17A5 0 0 170 240 1 1
TFEB POU5F1 0 0 113 241 1 2
TFEB MAP4K3 0 0 283 297 1 1
TFEB HPRT1 0 0 150 169 1 1
TFEB DDIT4 0 0 219 236 1 2
TFEB RHEB 0 0 556 575 1 2
TFEB MYB 0 0 0 155 1 1
TFEB HIST2H4B 0 0 105 203 1 1
TFEB FOXA2 0 0 0 152 1 1
TFEB NR1D1 0 0 145 168 1 2
TFEB MLANA 0 0 469 469 1 1
TFEB TECPR1 0 0 150 185 1 1
TFEB SZT2 0 0 153 173 1 1
TFEB GBA 0 0 452 508 1 1
TFEB RAB34 0 0 256 260 1 1
TFEB CLN5 0 0 213 382 1 1
TFEB BAG1 0 0 167 167 1 2
TFEB HIST1H4A 0 0 105 203 1 1
TFEB UCP1 0 0 202 202 1 2
TFEB FAM134B 0 0 170 169 1 1
TFEB SREBF1 0 0 325 243 1 1
TFEB HIST1H4K 0 0 105 203 1 1
TFEB SLC36A4 0 0 123 174 1 1
TFEB MGEA5 0 0 242 241 1 1
TFEB MAPK14 0 0 74 162 1 2
TFEB NFE2L1 0 0 95 151 1 1
TFEB CLN6 0 0 171 277 1 1
TFEB ONECUT2 0 0 267 293 1 1
TFEB SYK 0 0 60 159 1 2
TFEB HFE 0 0 0 207 1 1
TFEB GBA2 0 0 169 169 1 1
TFEB KIT 0 0 193 193 1 2
TFEB HIST1H3C 0 0 0 207 1 1
TFEB HIST1H3B 0 0 0 207 1 1
TFEB WT1 0 0 142 173 1 1
TFEB AMBRA1 0 0 506 536 1 2
TFEB PRKAA2 0 0 170 189 1 2
TFEB CRYBA1 0 0 134 198 1 1
TFEB NAGPA 0 0 171 232 1 1
TFEB D2HGDH 0 0 0 159 1 1
TFEB KIAA0226 0 0 254 254 1 1
TFEB WIPI1 0 0 509 602 1 2
TFEB DNM1L 0 0 248 279 1 2
TFEB RRAGB 0 0 519 571 1 1
TFEB PTEN 0 0 327 333 1 2
TFEB DSTYK 0 0 95 172 1 1
TFEB VEGFA 0 0 195 195 1 2
TFEB GABARAP 0 0 504 526 1 2
TFEB TNFRSF11A 0 0 0 216 1 1
TFEB HIST1H3A 0 0 0 207 1 1
TFEB PPARGC1B 0 0 166 188 1 1
TFEB ATP6V0A1 0 0 264 337 1 1
TFEB GFAP 0 0 181 181 1 2
TFEB IL10 0 0 134 152 1 2
TFEB ACTG1 0 0 233 252 1 1
TFEB NR1H4 0 0 340 355 1 1
TFEB ZHX3 0 0 119 174 1 1
TFEB ATG7 0 0 667 723 1 2
TFEB ENSG00000267261 0 0 0 165 1 1
TFEB TTI1 0 0 261 275 1 1
TFEB SOX10 0 0 308 345 1 1
TFEB SEPT3 0 0 0 256 1 1
TFEB VTI1B 0 0 150 168 1 2
TFEB DAP 0 0 292 292 1 2
TFEB M6PR 0 0 341 341 1 1
TFEB TRIM63 0 0 206 223 1 1
TFEB CTSD 0 0 660 700 1 2
TFEB NONO 0 0 414 414 1 1
TFEB SEC22B 0 0 162 162 1 1
TFEB MFSD8 0 0 166 341 1 1
TFEB TBP 0 0 128 182 1 1
TFEB FNIP1 0 0 454 468 1 1
TFEB PCBP1 0 0 82 202 1 1
TFEB RARA 0 0 120 172 1 2
TFEB AMDHD2 0 0 108 189 1 1
TFEB SETD2 0 0 212 242 1 1
TFEB STX7 0 0 150 202 1 2
TFEB DACH1 0 0 0 394 1 1
TFEB ULK1 0 0 631 658 1 2
TFEB TBX21 0 0 0 205 1 1
TFEB TBC1D14 246 0 91 291 1 2
TFEB RPS6KA1 0 0 167 222 1 1
TFEB PRKCA 0 0 161 171 1 1
TFEB AGFG1 0 0 166 179 1 1
TFEB WDFY4 0 0 57 240 1 1
TFEB MAP1LC3B 0 0 681 709 1 2
TFEB TYRP1 0 0 326 327 1 1
TFEB MGLL 0 0 141 162 1 1
TFEB ALKBH5 0 0 181 239 1 1
TFEB YBX3 0 0 114 175 1 1
TFEB ATG10 0 0 392 392 1 2
TFEB USP30 0 0 183 183 1 1
TFEB RT14 0 0 326 333 1 1
TFEB MYBL2 0 0 43 157 1 1
TFEB FUS 0 0 181 181 1 2
TFEB TTF1 0 0 0 188 1 1
TFEB UFM1 0 0 0 196 1 1
TFEB ATP4A 0 0 393 406 1 1
TFEB TBX19 0 0 0 151 1 1
TFEB YAP1 0 0 66 402 1 2
TFEB XBP1 0 0 263 293 1 2
TFEB ASB3 0 0 70 182 1 1
TFEB PRKD1 0 0 167 183 1 1
TFEB HIST2H3A 0 0 0 207 1 1
TFEB CALCOCO2 0 0 456 467 1 2
TFEB LAPTM5 0 0 120 174 1 1
TFEB ATG5 0 0 670 693 1 2
TFEB PPT1 0 0 293 320 1 1
TFEB CTSK 0 0 580 592 1 2
TFEB ZFP36L1 0 0 0 161 1 1
TFEB ESR1 0 0 146 188 1 2
TFEB HMGB1 0 0 147 181 1 2
TFEB IFNB1 0 0 95 151 1 1
TFEB MAP3K5 0 0 113 156 1 1
TFEB OPTN 0 0 459 491 1 2
TFEB UBQLN2 0 0 184 196 1 2
TFEB T 0 0 0 151 1 1
TFEB BACE1 0 0 230 282 1 2
TFEB ITGAM 0 0 107 163 1 1
TFEB TMEM55B 0 0 370 542 1 1
TFEB AIRE 0 0 0 442 1 1
TFEB PLIN2 0 0 206 254 1 2
TFEB RBM10 0 0 298 303 1 1
TFEB SIRT1 0 0 426 442 1 2
TFEB TBX6 0 0 0 151 1 1
TFEB EOMES 0 0 50 159 1 1
TFEB MCL1 0 0 150 183 1 2
TFEB LMNB1 0 0 173 197 1 1
TFEB SPI1 0 0 120 196 1 1
TFEB SMCR8 0 0 426 477 1 1
TFEB CTSB 0 0 595 617 1 2
TFEB ARF6 0 0 134 190 1 1
TFEB ATP6V0E1 0 0 322 368 1 1
TFEB STT3A 246 0 0 245 1 1
TFEB COX4I2 0 0 150 159 1 1
TFEB TBX22 0 0 0 154 1 1
TFEB ZC3HAV1 0 0 0 192 1 1
TFEB MAPT 128 0 328 388 1 2
TFEB BECN1 0 0 689 752 1 2
TFEB MET 0 0 387 397 1 2
TFEB LRRK2 0 0 298 339 1 2
TFEB ATXN3 0 0 171 208 1 2
TFEB VAC14 0 0 150 222 1 1
TFEB LRP2 0 0 141 159 1 1
TFEB HPS4 0 0 89 258 1 1
TFEB TLR2 0 0 122 165 1 2
TFEB PIK3CB 0 0 90 201 1 1
TFEB AMACR 0 0 370 370 1 1
TFEB RRAGD 0 0 561 635 1 1
TFEB LPIN1 0 0 359 382 1 2
TFEB WDR59 0 0 181 181 1 1
TFEB MAN2B1 0 0 70 183 1 1
TFEB YWHAZ 130 0 50 229 1 1
TFEB LMAN2L 0 0 0 185 1 1
TFEB RRAGC 0 0 560 634 1 1
TFEB DEPTOR 0 0 394 394 1 2
TFEB AJUBA 0 0 0 388 1 1
TFEB PISD 0 0 0 190 1 1
TFEB TCEB1 0 0 117 151 1 1
TFEB MLST8 0 0 427 527 1 1
TFEB DACH2 0 0 0 161 1 1
TFEB CAMK4 0 0 74 187 1 1
TFEB HIST1H3E 0 0 0 207 1 1
TFEB PGA4 0 0 0 290 1 1
TFEB HIST1H3J 0 0 0 207 1 1
TFEB SNX2 0 0 123 208 1 1
TFEB FOXK1 0 0 128 199 1 1
TFEB HSPA5 0 0 210 210 1 2
TFEB TFE3 814 800 958 965 1 2
TFEB SOD2 0 0 141 200 1 2
TFEB DNAJC13 0 0 70 213 1 1
TFEB YTHDF1 0 0 90 165 1 1
TFEB EPAS1 0 0 150 229 1 2
TFEB RAB39B 0 0 210 323 1 1
TFEB KRAS 0 0 167 230 1 2
TFEB FOXO1 0 0 404 451 1 2
TFEB ASPSCR1 0 0 685 685 1 1
TFEB TBC1D1 0 0 136 372 1 1
TFEB PBRM1 0 0 289 314 1 1
TFEB GSK3B 0 0 161 238 1 2
TFEB KRT7 0 0 324 323 1 1
TFEB CDKN2A 0 0 180 192 1 2
TFEB PRCC 0 0 616 624 1 1
TFEB GUSB 0 0 166 184 1 1
TFEB UNC119 0 0 89 155 1 1
TFEB KLF2 0 0 47 154 1 1
TFEB HIST2H4A 0 0 105 203 1 1
TFEB HIST1H3I 0 0 0 207 1 1
TFEB WDR41 0 0 370 474 1 1
TFEB JAZF1 0 0 0 206 1 1
TFEB ATP6V1C1 0 0 138 200 1 1
TFEB CEBPB 0 0 217 257 1 2
TFEB TBC1D7 0 0 325 325 1 2
TFEB SMPD1 0 0 323 323 1 1
TFEB ATG16L1 0 0 505 516 1 2
TFEB HIST3H3 0 0 0 207 1 1
TFEB MT-CO2 226 0 123 302 1 1
TFEB TBX15 0 0 0 154 1 1
TFEB TMEM106B 0 0 334 379 1 1
TFEB TBX10 0 0 0 154 1 1
TFEB GOLGA1 0 0 90 173 1 1
TFEB RIPK1 0 0 157 171 1 2
TFEB YWHAH 130 0 0 173 1 1
TFEB LAMTOR1 0 0 394 459 1 1
TFEB LIPK 0 0 253 258 1 1
TFEB ATG101 0 0 465 506 1 2
TFEB HSPB8 0 0 229 273 1 2
TFEB PLEKHM1 0 0 201 231 1 1
TFEB NLRP3 0 0 283 303 1 2
TFEB TRPM2 0 0 151 321 1 2
TFEB ESRRG 0 0 0 176 1 1
TFEB PLIN3 0 0 213 230 1 1
TFEB ATG4D 0 0 282 302 1 2
TFEB CTSZ 0 0 155 225 1 1
TFEB KAT8 0 0 206 260 1 1
TFEB PSMB9 0 0 73 334 1 1
TFEB CDH16 0 0 235 235 1 1
TFEB VPS29 0 0 81 157 1 1
TFEB SMURF1 0 0 164 188 1 1
TFEB CASP3 0 0 337 354 1 2
TFEB NQO1 0 0 112 200 1 2
TFEB ATP6V1B2 0 0 253 334 1 1
TFEB ATG12 0 0 561 578 1 2
TFEB ASAH1 0 0 161 214 1 1
TFEB CTSS 0 0 95 186 1 1
TFEB DIRAS3 0 0 126 164 1 2
TFEB OMA1 0 0 113 265 1 1
TFEB PNPLA8 0 0 95 151 1 1
TFEB CSTB 0 0 209 210 1 1
TFEB GPR137B 0 0 63 190 1 1
TFEB BHLHA15 0 0 0 297 1 1
TFEB CYBB 0 0 204 265 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0003700 Molecular Function DNA-binding transcription factor activity enables IDA
GO:0003700 Molecular Function DNA-binding transcription factor activity enables NAS
GO:0000981 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific enables IBA
GO:0000981 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific enables ISA
GO:0000978 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding enables IBA
GO:0019899 Molecular Function enzyme binding enables IPI
GO:0005515 Molecular Function protein binding enables IPI
GO:0046983 Molecular Function protein dimerization activity enables IEA
GO:1990837 Molecular Function sequence-specific double-stranded DNA binding enables IDA
GO:0000976 Molecular Function transcription cis-regulatory region binding enables IDA
GO:0002250 Biological Process adaptive immune response involved_in IEA
GO:0140367 Biological Process antibacterial innate immune response involved_in IDA
GO:0006914 Biological Process autophagy involved_in IEA
GO:0034198 Biological Process cellular response to amino acid starvation involved_in IDA
GO:0009267 Biological Process cellular response to starvation involved_in IDA
GO:0001892 Biological Process embryonic placenta development involved_in ISS
GO:0006959 Biological Process humoral immune response involved_in ISS
GO:0032418 Biological Process lysosome localization involved_in IMP
GO:0007040 Biological Process lysosome organization involved_in IDA
GO:0007040 Biological Process lysosome organization involved_in IMP
GO:0045893 Biological Process positive regulation of DNA-templated transcription involved_in IDA
GO:0010508 Biological Process positive regulation of autophagy involved_in IDA
GO:0010508 Biological Process positive regulation of autophagy involved_in IMP
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IDA
GO:0006355 Biological Process regulation of DNA-templated transcription involved_in NAS
GO:0006357 Biological Process regulation of transcription by RNA polymerase II involved_in IBA
GO:0000785 Cellular Component chromatin part_of ISA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005765 Cellular Component lysosomal membrane located_in IDA
GO:0005634 Cellular Component nucleus is_active_in IBA
GO:0005634 Cellular Component nucleus is_active_in IDA
GO:0005634 Cellular Component nucleus located_in IDA
GO:0005634 Cellular Component nucleus located_in NAS
Pathways
Name DB ID
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (WP3844) WikiPathways WP3844_r107714
Type 2 papillary renal cell carcinoma (WP4241) WikiPathways WP4241_r123413
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001167827 3 mRNA transcript variant 2 NC_000006 Reference
NM_001271943 2 mRNA transcript variant 5 NC_000006 Reference
NM_001271944 2 mRNA transcript variant 3 NC_000006 Reference
NM_007162 3 mRNA transcript variant 1 NC_000006 Reference
NM_001271945 2 mRNA transcript variant 4 NC_000006 Reference
XM_005249411 2 mRNA transcript variant X2 NC_000006 Reference
XM_047419361 1 mRNA transcript variant X1 NC_000006 Reference
XM_006715212 5 mRNA transcript variant X3 NC_000006 Reference