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EPM2A

EPM2A glucan phosphatase, laforin
General Information
Name EPM2A glucan phosphatase, laforin
Alias
  • laforin
  • EPM2A, laforin glucan phosphatase
  • LAFPTPase
  • epilepsy, progressive myoclonus type 2, Lafora disease (laforin)
  • epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
  • glucan phosphatase
  • glycogen phosphatase
  • lafora PTPase
Gene_family Atypical dual specificity phosphatases
organism Homo sapiens
entrez_id 7957
location 6q24.3
transcript_count 17
exon_count 15
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a dual-specificity phosphatase and may be involved in the regulation of glycogen metabolism. The protein acts on complex carbohydrates to prevent glycogen hyperphosphorylation, thus avoiding the formation of insoluble aggregates. Loss-of-function mutations in this gene have been associated with Lafora disease, a rare, adult-onset recessive neurodegenerative disease, which results in myoclonus epilepsy and usually results in death several years after the onset of symptoms. The disease is characterized by the accumulation of insoluble particles called Lafora bodies, which are derived from glycogen. [provided by RefSeq, Jan 2018]
    Stringdb Laforin; Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Dephosphorylates phosphotyrosine and synthetic substrates, such as para- nitrophenylphosphat [...]
    nextProt None
    nextProt Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:16901901, PubMed:23922729, PubMed:26231210, PubMed:25538239, PubMed:25544560). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:11001928, PubMed:11220751, PubMed:11739371, PubMed:14532330, PubMed:16971387, PubMed:18617530, PubMed:22036712, PubMed:23922729, PubMed:14722920). Has been shown to dephosphorylate MAPT (By similarity). Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin (PubMed:23922729). Also promotes proteasome-independent protein degradation through the macroautophagy pathway (PubMed:20453062).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
EPM2A BioGRID HAPSTR1 GeneID BioGRID Positive Genetic
EPM2A BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID BRDT GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID NHLRC1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
EPM2A BioGRID STBD1 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID PYGB GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID BECN1 GeneID BioGRID Affinity Capture-Western; Co-localization
EPM2A BioGRID PIK3C3 GeneID BioGRID Affinity Capture-Western; Co-localization
EPM2A BioGRID PIK3R4 GeneID BioGRID Affinity Capture-Western; Co-localization
EPM2A BioGRID MCMBP GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID ANKMY2 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID CLUH GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID CCT5 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID PPP6R1 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID HSPA4L GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID STIP1 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID TOMM34 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID PTGES3 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID PSME3 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID TOMM70 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID PPP6R2 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID AIP GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID VCP GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID VBP1 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID PSMD4 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID PSMB1 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID PPP5C GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID HSPA4 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID FKBP5 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID ATXN1 GeneID BioGRID Affinity Capture-Western
EPM2A BioGRID EPM2A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EPM2A BioGRID PPP1R3D GeneID BioGRID Affinity Capture-Western; FRET; Two-hybrid
EPM2A BioGRID PPP1R3C GeneID BioGRID Affinity Capture-Western; Two-hybrid
EPM2A BioGRID HEXIM1 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID PRKAB2 GeneID BioGRID Affinity Capture-MS; Two-hybrid
EPM2A BioGRID OTUB1 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western
EPM2A BioGRID UBE2N GeneID BioGRID Affinity Capture-Western
EPM2A BioGRID TOPORS GeneID BioGRID Two-hybrid
EPM2A BioGRID HMGXB4 GeneID BioGRID Two-hybrid
EPM2A BioGRID COX5A GeneID BioGRID Two-hybrid
EPM2A BioGRID TDG GeneID BioGRID Two-hybrid
EPM2A BioGRID PSMC3 GeneID BioGRID Two-hybrid
EPM2A BioGRID PKM GeneID BioGRID Affinity Capture-Western; Two-hybrid
EPM2A BioGRID EIF2B1 GeneID BioGRID Two-hybrid
EPM2A BioGRID SRPK2 GeneID BioGRID Biochemical Activity
EPM2A BioGRID RPL10 GeneID BioGRID Affinity Capture-MS
EPM2A BioGRID PRKAA1 GeneID BioGRID Biochemical Activity
EPM2A BioGRID STUB1 GeneID BioGRID Affinity Capture-Western
EPM2A BioGRID PRKAA2 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Two-hybrid
EPM2A BioGRID GSK3B GeneID BioGRID Affinity Capture-Western; Two-hybrid
EPM2A Protein NFU1 GeneID HPRD
EPM2A Protein EPM2AIP1 GeneID HPRD
EPM2A BioGRID NFU1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EPM2A Protein EPM2AIP1 GeneID BIND Laforin interacts with EPM2AIP1.
StringDB
A B experiments database textmining combined score hadb nhadb
EPM2A NPSR1 0 0 0 201 1 1
EPM2A PTPRC 0 0 147 236 1 1
EPM2A TST 0 0 171 190 1 1
EPM2A PPP1R3D 485 0 673 828 1 1
EPM2A HUNK 0 0 0 171 1 1
EPM2A ENSG00000271810 0 0 0 159 1 1
EPM2A RHBDF2 0 0 0 175 1 1
EPM2A NMD3 0 0 0 403 1 1
EPM2A KIAA1468 0 0 0 177 1 1
EPM2A ATG9A 0 0 0 152 1 2
EPM2A RPL24 0 0 0 266 1 1
EPM2A DUSP16 0 0 134 157 1 1
EPM2A AURKA 0 0 0 183 1 2
EPM2A EPRS 0 0 0 152 1 1
EPM2A UBE2E1 0 0 235 248 1 1
EPM2A ENSG00000137843 0 0 0 157 1 1
EPM2A JUNB 0 0 0 156 1 1
EPM2A SQSTM1 270 0 357 510 1 2
EPM2A MAPK3 0 0 81 320 1 2
EPM2A RND1 0 0 0 155 1 1
EPM2A STK38 0 0 0 212 1 1
EPM2A ATF2 0 0 0 168 1 1
EPM2A PSEN1 0 0 127 164 1 2
EPM2A RHOV 0 0 0 155 1 1
EPM2A MYH7B 0 0 0 156 1 1
EPM2A SI 0 0 211 211 1 1
EPM2A DPYSL2 0 0 411 415 1 1
EPM2A TPP1 0 0 157 156 1 1
EPM2A PYGB 0 0 336 363 1 1
EPM2A JUN 0 0 0 156 1 2
EPM2A ARL4A 0 0 0 151 1 1
EPM2A RPL37A 0 0 0 202 1 1
EPM2A GIPC3 0 0 66 166 1 1
EPM2A CIB4 0 0 0 166 1 1
EPM2A MYO3A 0 0 0 175 1 1
EPM2A AIF1 0 0 96 198 1 2
EPM2A STXBP5 0 0 0 682 1 1
EPM2A ZNF213 0 0 0 226 1 1
EPM2A MED18 0 0 155 154 1 1
EPM2A PPM1F 0 0 0 219 1 1
EPM2A ENSG00000270024 0 0 0 167 1 1
EPM2A WBSCR16 0 0 134 170 1 1
EPM2A RPL39 0 0 0 195 1 1
EPM2A PP2D1 0 0 0 219 1 1
EPM2A CDC25C 0 0 0 210 1 2
EPM2A RPL3 0 0 0 221 1 1
EPM2A ENTPD4 0 0 181 181 1 1
EPM2A RABL2A 0 0 0 151 1 1
EPM2A EPN2 0 0 143 215 1 1
EPM2A BATF3 0 0 0 168 1 1
EPM2A KCTD7 0 0 212 212 1 1
EPM2A RFPL3 0 0 211 211 1 1
EPM2A SRPK1 0 0 0 169 1 1
EPM2A PPP2CB 0 0 0 210 1 1
EPM2A KLRD1 0 0 415 414 1 1
EPM2A MAPK8 0 0 96 257 1 2
EPM2A PKDCC 0 0 0 153 1 1
EPM2A PPP3R2 0 0 49 173 1 1
EPM2A CHERP 0 0 207 207 1 1
EPM2A PRRT2 0 0 60 221 1 1
EPM2A PPM1L 0 0 0 219 1 1
EPM2A RAC3 0 0 0 155 1 2
EPM2A PDP1 0 0 0 204 1 1
EPM2A DUSP12 0 0 52 153 1 1
EPM2A PTPN3 0 0 321 525 1 1
EPM2A PTPRS 0 0 338 372 1 1
EPM2A MRPL3 0 0 0 156 1 1
EPM2A GAK 0 0 120 302 1 1
EPM2A CDC6 0 0 0 163 1 1
EPM2A HSPA4 69 0 450 475 1 1
EPM2A POLR1E 0 0 0 222 1 1
EPM2A PCBP2 0 0 0 181 1 1
EPM2A GPHN 0 0 314 322 1 1
EPM2A RPL17 0 0 0 190 1 1
EPM2A CLTC 0 0 0 261 1 1
EPM2A DYRK3 0 0 0 180 1 1
EPM2A RNF32 0 0 0 206 1 1
EPM2A CAPS2 0 0 166 197 1 1
EPM2A RPL19 0 0 0 189 1 1
EPM2A CALML5 0 0 49 156 1 1
EPM2A PPP2R1B 0 0 0 177 1 1
EPM2A DUSP9 0 0 127 508 1 1
EPM2A PVALB 0 0 155 266 1 1
EPM2A METAP1 0 0 0 186 1 1
EPM2A CELF5 0 0 169 169 1 1
EPM2A DUSP7 0 0 0 459 1 1
EPM2A ELAVL1 0 0 151 150 1 2
EPM2A LEF1 0 0 0 177 1 1
EPM2A IPO5 0 0 0 166 1 1
EPM2A ARSG 0 0 123 261 1 1
EPM2A SNCAIP 0 0 193 237 1 2
EPM2A SIRT6 0 0 0 174 1 2
EPM2A USP32 0 0 52 201 1 1
EPM2A SGK494 0 0 0 316 1 1
EPM2A CDK16 0 0 0 193 1 1
EPM2A COX10 0 0 0 210 1 1
EPM2A PRKCZ 0 0 112 200 1 1
EPM2A DUSP10 0 0 202 202 1 1
EPM2A RAB32 0 0 0 450 1 2
EPM2A MAP3K11 0 0 48 150 1 1
EPM2A LIPI 0 0 210 210 1 1
EPM2A PPP1CB 0 0 0 204 1 1
EPM2A ENSG00000257411 0 0 0 366 1 1
EPM2A TP53 0 0 181 196 1 2
EPM2A MDM2 0 0 73 215 1 2
EPM2A TIMM50 0 0 0 183 1 1
EPM2A PRPSAP1 0 0 0 315 1 1
EPM2A MYH14 0 0 0 156 1 1
EPM2A TXNL1 0 0 536 536 1 1
EPM2A BTAF1 0 0 0 197 1 1
EPM2A PPP1CC 0 0 181 325 1 1
EPM2A HTT 0 0 203 278 1 2
EPM2A GYG2 0 600 218 680 1 1
EPM2A PSTPIP2 0 0 0 172 1 1
EPM2A IRAK1 0 0 0 153 1 1
EPM2A RPL36 0 0 0 201 1 1
EPM2A EDA 0 0 0 281 1 1
EPM2A NOA1 0 0 0 178 1 1
EPM2A PTPN4 0 0 244 361 1 1
EPM2A CALM3 0 0 60 166 1 1
EPM2A MELK 0 0 142 258 1 1
EPM2A PPP1R11 0 0 180 179 1 1
EPM2A MYO7B 0 0 0 175 1 1
EPM2A MYH6 0 0 0 156 1 1
EPM2A RHBDL3 0 0 0 168 1 1
EPM2A UBE2H 0 0 126 235 1 1
EPM2A PPP5C 69 0 45 212 1 1
EPM2A MAD2L1 0 0 0 184 1 1
EPM2A RPL35A 0 0 0 203 1 1
EPM2A MXRA7 0 0 0 398 1 1
EPM2A PARK2 0 0 284 324 1 1
EPM2A DDX49 0 0 0 150 1 1
EPM2A RPL17-C18orf32 0 0 0 190 1 1
EPM2A CDC14A 0 0 381 496 1 1
EPM2A ENSG00000261832 0 0 164 202 1 1
EPM2A RICTOR 0 0 0 193 1 2
EPM2A PIM1 0 0 0 171 1 1
EPM2A RPL27 0 0 0 216 1 1
EPM2A PPP1R3C 852 600 841 990 1 1
EPM2A MYO15A 0 0 0 175 1 1
EPM2A UBXN7 0 0 0 159 1 1
EPM2A RPL15 0 0 0 205 1 1
EPM2A DUSP4 0 0 158 386 1 1
EPM2A B3GALT4 0 0 54 154 1 1
EPM2A MTMR2 0 0 426 427 1 1
EPM2A ENSG00000254536 0 0 0 182 1 1
EPM2A LSG1 0 0 0 296 1 1
EPM2A STK11 0 0 48 189 1 2
EPM2A ST13 0 0 267 283 1 2
EPM2A UBE2D3 0 0 125 220 1 1
EPM2A RHOBTB2 0 0 0 155 1 1
EPM2A CKAP5 0 0 0 200 1 1
EPM2A CLTCL1 0 0 0 261 1 1
EPM2A ARL14 0 0 0 151 1 1
EPM2A RHOJ 0 0 0 155 1 1
EPM2A POLR2A 0 0 0 157 1 1
EPM2A SIRT2 0 0 53 166 1 2
EPM2A STON1 0 0 74 190 1 1
EPM2A GRID2IP 0 0 0 199 1 1
EPM2A STAT4 0 0 0 196 1 1
EPM2A RPL13 0 0 0 275 1 1
EPM2A PLK4 0 0 0 219 1 1
EPM2A DUPD1 0 0 457 457 1 1
EPM2A PTP4A2 0 0 72 151 1 1
EPM2A ESPL1 0 0 0 157 1 1
EPM2A DUSP5 0 0 233 512 1 1
EPM2A TCF7L2 0 0 0 177 1 1
EPM2A ARL5B 0 0 0 151 1 1
EPM2A MAP2K7 0 0 0 322 1 1
EPM2A TSSK3 0 0 0 171 1 1
EPM2A BAG3 0 0 76 166 1 2
EPM2A CPA6 0 0 96 155 1 1
EPM2A ARF3 0 0 0 151 1 1
EPM2A RPL30 0 0 0 262 1 1
EPM2A ATXN1 270 0 101 315 1 1
EPM2A ENSG00000258989 0 0 0 175 1 1
EPM2A HRAS 0 0 63 152 1 2
EPM2A CTNNB1 0 0 150 234 1 2
EPM2A ARL8A 0 0 0 151 1 1
EPM2A RHOBTB1 0 0 0 155 1 1
EPM2A DCLK3 0 0 126 158 1 1
EPM2A PASK 0 0 0 251 1 1
EPM2A ORC1 0 0 0 163 1 1
EPM2A GTF2H5 0 0 46 256 1 1
EPM2A EPM2AIP1 213 0 785 890 1 1
EPM2A MTOR 0 0 203 278 1 2
EPM2A TRIB2 0 0 0 171 1 1
EPM2A CLK3 0 0 0 247 1 1
EPM2A PPP4C 0 0 0 171 1 1
EPM2A MAP3K2 0 0 0 207 1 1
EPM2A CHP1 0 0 49 173 1 1
EPM2A PIK3C3 0 0 84 190 1 2
EPM2A RPL9 0 0 0 215 1 1
EPM2A STAT1 0 0 67 172 1 2
EPM2A TRIM71 0 0 293 368 1 1
EPM2A NTPCR 0 0 242 701 1 1
EPM2A RPL32 0 0 0 230 1 1
EPM2A PI4KA 0 0 0 153 1 1
EPM2A YWHAH 0 0 0 189 1 1
EPM2A POLR1A 0 0 0 170 1 1
EPM2A NFU1 270 0 870 901 1 1
EPM2A IQCB1 0 0 0 156 1 1
EPM2A STON1-GTF2A1L 0 0 0 161 1 1
EPM2A SFN 0 0 0 189 1 2
EPM2A PRCC 0 0 119 316 1 1
EPM2A KCNQ2 0 0 63 189 1 1
EPM2A PTPN12 0 0 173 244 1 1
EPM2A MYH1 0 0 0 156 1 1
EPM2A SH2D1A 0 0 440 459 1 1
EPM2A PTPN5 0 0 134 253 1 1
EPM2A RPL31 0 0 0 221 1 1
EPM2A ATG12 0 0 108 233 1 2
EPM2A PRKCQ 0 0 0 175 1 2
EPM2A TRIM56 0 0 0 190 1 1
EPM2A ARPC5L 0 0 171 171 1 1
EPM2A GRM1 0 0 137 383 1 1
EPM2A CSTB 0 0 455 455 1 1
EPM2A GFPT1 0 0 0 175 1 1
EPM2A TRIB3 0 0 0 171 1 2
EPM2A MYH8 0 0 0 156 1 1
EPM2A HSPA1B 0 0 0 171 1 1
EPM2A LIMK1 0 0 0 153 1 1
EPM2A MYO5B 0 0 0 156 1 1
EPM2A CHP2 0 0 0 166 1 1
EPM2A PPP1R3A 0 0 391 445 1 1
EPM2A UGP2 0 0 217 223 1 1
EPM2A STK38L 0 0 0 212 1 1
EPM2A PRDM8 0 0 580 641 1 1
EPM2A WEE1 0 0 0 176 1 1
EPM2A ARF6 0 0 0 151 1 1
EPM2A ARL4C 0 0 0 151 1 1
EPM2A PIM3 0 0 0 171 1 1
EPM2A PRKCH 0 0 66 197 1 1
EPM2A RPL3L 0 0 0 221 1 1
EPM2A DDT 0 0 161 179 1 1
EPM2A LRRK2 0 0 66 247 1 2
EPM2A MYO3B 0 0 0 175 1 1
EPM2A MYH13 0 0 0 156 1 1
EPM2A DTNBP1 0 0 181 266 1 1
EPM2A DUSP3 0 0 681 750 1 1
EPM2A RPL10 128 0 0 294 1 1
EPM2A YWHAZ 0 0 0 189 1 1
EPM2A FOS 0 0 0 168 1 2
EPM2A PTK6 0 0 0 175 1 2
EPM2A MYO5C 0 0 0 156 1 1
EPM2A SRPK2 0 0 0 169 1 1
EPM2A RAB11B 0 0 0 151 1 1
EPM2A IRAK3 0 0 0 153 1 1
EPM2A PTPN11 0 0 233 273 1 1
EPM2A FOXRED2 0 0 0 295 1 1
EPM2A MYO1F 0 0 0 156 1 1
EPM2A PTPRR 0 0 91 169 1 1
EPM2A DUSP14 0 0 124 268 1 1
EPM2A UBE2J2 0 0 128 169 1 1
EPM2A DYRK1A 0 0 54 191 1 1
EPM2A ARL13B 0 0 0 169 1 1
EPM2A RARA 0 0 46 162 1 2
EPM2A PCBP1 0 0 0 181 1 1
EPM2A RPL18A 0 0 0 216 1 1
EPM2A RAC1 0 0 0 155 1 2
EPM2A PPP1CA 0 0 126 290 1 1
EPM2A MAPK6 0 0 507 635 1 1
EPM2A RPL10L 0 0 0 224 1 1
EPM2A ORC2 0 0 0 162 1 1
EPM2A PCBP3 0 0 0 181 1 1
EPM2A MCL1 0 0 413 423 1 2
EPM2A SIRT1 0 0 0 156 1 2
EPM2A GBE1 0 0 595 626 1 1
EPM2A HIPK2 0 0 85 217 1 2
EPM2A PRKAG2 0 0 166 202 1 1
EPM2A TMEM8B 0 0 0 199 1 1
EPM2A PTPN1 0 0 341 397 1 1
EPM2A PTPRZ1 0 0 92 170 1 1
EPM2A MYO10 0 0 0 175 1 1
EPM2A HYDIN 0 0 113 168 1 1
EPM2A PPP5D1 0 0 0 185 1 1
EPM2A ATG5 0 0 113 161 1 2
EPM2A WDR18 0 0 0 162 1 1
EPM2A GRIN1 0 0 0 161 1 1
EPM2A PI4KB 0 0 0 170 1 1
EPM2A FAM171A2 0 0 108 190 1 1
EPM2A PANK2 0 0 0 303 1 1
EPM2A PRKAA2 270 0 53 415 1 2
EPM2A MAPK7 0 0 0 291 1 1
EPM2A STXBP5L 0 0 0 404 1 1
EPM2A DYRK4 0 0 0 180 1 1
EPM2A PTEN 0 0 212 239 1 2
EPM2A MAPK14 0 0 0 291 1 2
EPM2A RORB 0 0 102 155 1 1
EPM2A PPP1R8 0 0 410 451 1 1
EPM2A MAPK10 0 0 0 185 1 2
EPM2A UBA52 0 900 0 917 1 1
EPM2A MAP3K3 0 0 0 207 1 1
EPM2A PTPRG 0 0 103 202 1 1
EPM2A GBA2 0 0 47 160 1 1
EPM2A G6PD 0 0 85 200 1 1
EPM2A AXIN1 0 0 357 365 1 1
EPM2A RPL37 0 0 0 190 1 1
EPM2A RNF39 0 0 150 187 1 1
EPM2A ATG7 0 0 95 170 1 2
EPM2A TRAT1 0 0 234 281 1 1
EPM2A RPL38 0 0 0 231 1 1
EPM2A HIVEP2 0 0 107 167 1 1
EPM2A RPL21 0 0 112 260 1 1
EPM2A ILVBL 0 0 194 211 1 1
EPM2A PAK6 0 0 0 157 1 1
EPM2A PPP2CA 0 0 0 210 1 1
EPM2A YWHAQ 0 0 90 230 1 1
EPM2A PPM1K 0 0 0 219 1 1
EPM2A JUND 0 0 0 156 1 1
EPM2A LRGUK 0 0 0 151 1 1
EPM2A PRKAA1 270 0 0 382 1 2
EPM2A FRAT1 0 0 436 436 1 1
EPM2A WDR77 0 0 0 158 1 1
EPM2A PTPRE 0 0 0 220 1 1
EPM2A IRAK2 0 0 0 153 1 1
EPM2A MAP2K2 0 0 398 533 1 1
EPM2A ATF7 0 0 0 168 1 1
EPM2A MYO1B 0 0 0 165 1 1
EPM2A PPP1R3G 0 0 261 340 1 1
EPM2A MYH2 0 0 0 156 1 1
EPM2A LDLR 0 0 64 154 1 2
EPM2A TSSK2 0 0 0 171 1 1
EPM2A UBB 0 900 0 907 1 1
EPM2A CLK1 0 0 0 247 1 1
EPM2A LRP6 0 0 431 448 1 1
EPM2A MTMR1 0 0 143 166 1 1
EPM2A DUSP26 0 0 283 282 1 1
EPM2A HIPK3 0 0 0 180 1 1
EPM2A UBE2W 0 0 123 385 1 1
EPM2A ANKRD26 0 0 50 227 1 1
EPM2A NHLRC1 870 900 990 999 1 1
EPM2A RPLP0 0 0 0 156 1 1
EPM2A RABL2B 0 0 0 151 1 1
EPM2A TSSK1B 0 0 0 171 1 1
EPM2A SHPRH 0 0 203 342 1 1
EPM2A CDK17 0 0 0 193 1 1
EPM2A SNX25 0 0 240 256 1 1
EPM2A ITSN2 0 0 0 167 1 1
EPM2A PPEF2 0 0 0 153 1 1
EPM2A PPTC7 0 0 0 248 1 1
EPM2A FCHO2 0 0 0 172 1 1
EPM2A WDR45 0 0 142 308 1 2
EPM2A PPP2R1A 0 0 0 177 1 1
EPM2A MAPK1 0 0 0 291 1 2
EPM2A PKM 270 0 162 376 1 1
EPM2A PTPN23 0 0 0 171 1 1
EPM2A RPL29 0 0 0 213 1 1
EPM2A PINK1 0 0 143 222 1 2
EPM2A GRM5 0 0 0 188 1 1
EPM2A MYH4 0 0 0 156 1 1
EPM2A PPP3CA 0 0 0 297 1 1
EPM2A PPM1E 0 0 0 219 1 1
EPM2A CLHC1 0 0 0 261 1 1
EPM2A MGAM 0 0 205 205 1 1
EPM2A KLHL33 0 0 95 157 1 1
EPM2A RPL26 0 0 0 194 1 1
EPM2A GNL1 0 0 0 296 1 1
EPM2A CDK18 0 0 0 193 1 1
EPM2A WEE2 0 0 0 176 1 1
EPM2A CTDP1 0 0 0 151 1 1
EPM2A RASD2 0 0 0 278 1 1
EPM2A RPL35 0 0 0 240 1 1
EPM2A ARF4 0 0 0 151 1 1
EPM2A PHKG1 0 0 134 168 1 1
EPM2A AARS2 0 0 124 433 1 1
EPM2A SKP1 0 0 43 151 1 2
EPM2A RPL11 0 0 0 201 1 1
EPM2A RAC2 0 0 0 155 1 1
EPM2A RAB11A 0 0 0 151 1 2
EPM2A TBK1 0 0 57 163 1 2
EPM2A MRPL22 0 0 0 158 1 1
EPM2A NDFIP1 0 0 0 224 1 1
EPM2A RPL26L1 0 0 0 194 1 1
EPM2A CLN8 0 0 107 310 1 1
EPM2A CLK4 0 0 0 247 1 1
EPM2A PRKCD 0 0 0 175 1 2
EPM2A TAF5L 0 0 60 235 1 1
EPM2A CDC42 0 0 0 155 1 2
EPM2A EIF6 0 0 0 343 1 1
EPM2A MPHOSPH8 0 0 0 162 1 1
EPM2A PRPF4B 0 0 0 196 1 1
EPM2A PKMYT1 0 0 0 176 1 1
EPM2A ENSG00000250232 0 0 48 232 1 1
EPM2A FMNL1 0 0 0 155 1 1
EPM2A BBOX1 0 0 157 233 1 1
EPM2A FOXO3 0 0 96 176 1 2
EPM2A MYO1E 0 0 0 156 1 1
EPM2A MAP3K19 0 0 0 207 1 1
EPM2A TESC 0 0 134 246 1 1
EPM2A JDP2 0 0 0 168 1 1
EPM2A BIRC6 0 0 0 172 1 1
EPM2A NIM1K 0 0 0 171 1 1
EPM2A RHOG 0 0 0 155 1 1
EPM2A RPL8 0 0 0 201 1 1
EPM2A USP6 0 0 0 176 1 1
EPM2A EFHC1 0 0 180 179 1 1
EPM2A WDR38 0 0 0 157 1 1
EPM2A MYH9 0 0 0 167 1 1
EPM2A SIRT7 0 0 0 174 1 2
EPM2A GNL2 0 0 0 262 1 1
EPM2A HSPA8 0 0 90 198 1 2
EPM2A RSL24D1 0 0 0 284 1 1
EPM2A RHOA 0 0 48 161 1 2
EPM2A ERAS 0 0 138 220 1 1
EPM2A LLGL2 0 0 0 194 1 1
EPM2A TCF7L1 0 0 0 177 1 1
EPM2A ENSG00000272762 0 0 0 181 1 1
EPM2A UBE2N 270 0 450 589 1 1
EPM2A RHOQ 0 0 0 155 1 1
EPM2A ZNF622 0 0 0 319 1 1
EPM2A SPG7 0 0 0 225 1 1
EPM2A STUB1 270 0 457 653 1 2
EPM2A KLHL38 0 0 92 170 1 1
EPM2A ACP1 0 0 322 375 1 1
EPM2A INS 0 0 170 169 1 2
EPM2A RPL36A-HNRNPH2 0 0 0 187 1 1
EPM2A KEAP1 0 0 0 208 1 2
EPM2A SIRT3 0 0 0 156 1 2
EPM2A STMND1 0 0 334 334 1 1
EPM2A ARL6 0 0 0 151 1 1
EPM2A MYO9A 0 0 0 192 1 1
EPM2A EIF2B1 192 0 0 198 1 1
EPM2A FOSL1 0 0 0 168 1 1
EPM2A IL3 0 0 309 309 1 1
EPM2A PNPLA2 0 0 0 151 1 2
EPM2A TMEM8A 0 0 0 199 1 1
EPM2A MYO1G 0 0 0 165 1 1
EPM2A DYRK2 0 0 0 180 1 1
EPM2A RPL22 0 0 0 208 1 1
EPM2A METAP1D 0 0 0 186 1 1
EPM2A WDR33 0 0 0 158 1 1
EPM2A PPP1R16B 0 0 165 197 1 1
EPM2A RPL36AL 0 0 0 187 1 1
EPM2A MAPK12 0 0 0 291 1 1
EPM2A CALB1 0 0 52 159 1 1
EPM2A POLDIP3 0 0 0 232 1 1
EPM2A AURKC 0 0 0 183 1 1
EPM2A BATF 0 0 0 168 1 1
EPM2A RPL7 0 0 0 201 1 1
EPM2A SNCA 0 0 182 255 1 2
EPM2A SCO1 0 0 0 561 1 1
EPM2A HSPA1A 0 0 411 491 1 1
EPM2A RPL36A 0 0 0 187 1 1
EPM2A PLK5 0 0 0 219 1 1
EPM2A ENSG00000268434 0 0 0 222 1 1
EPM2A ARL17B 0 0 0 151 1 1
EPM2A PRPSAP2 0 0 0 315 1 1
EPM2A STYX 0 0 325 474 1 1
EPM2A TCF7 0 0 0 177 1 1
EPM2A ETV1 0 0 0 252 1 1
EPM2A LIMK2 0 0 0 153 1 1
EPM2A RASD1 0 0 0 192 1 1
EPM2A SPOP 0 0 0 218 1 1
EPM2A LAMP2 45 0 154 190 1 2
EPM2A APOLD1 0 0 143 328 1 1
EPM2A VCP 63 0 0 150 1 2
EPM2A RPL4 0 0 0 201 1 1
EPM2A YWHAE 0 0 60 205 1 1
EPM2A GTPBP4 0 0 0 187 1 1
EPM2A DUSP22 0 0 235 235 1 1
EPM2A OTUB1 270 0 0 270 1 1
EPM2A PAK3 0 0 0 157 1 1
EPM2A SURF1 0 0 0 302 1 1
EPM2A SMARCB1 0 0 0 167 1 1
EPM2A CD244 0 0 482 482 1 1
EPM2A PYGM 0 0 125 206 1 1
EPM2A PRKAB1 0 0 320 324 1 2
EPM2A ARL9 0 0 0 151 1 1
EPM2A AURKB 0 0 0 183 1 1
EPM2A ZNRD1 0 0 134 688 1 1
EPM2A ARL4D 0 0 0 151 1 1
EPM2A RAB38 0 0 0 249 1 1
EPM2A PAK2 0 0 0 157 1 1
EPM2A MTM1 0 0 132 221 1 2
EPM2A ARL5C 0 0 0 151 1 1
EPM2A MAPK9 0 0 0 173 1 2
EPM2A CHEK2 0 0 0 159 1 1
EPM2A PLK2 0 0 0 219 1 1
EPM2A PRKAB2 706 0 392 814 1 1
EPM2A RNF19A 0 0 169 362 1 1
EPM2A ARL11 0 0 0 151 1 1
EPM2A RPL22L1 0 0 0 208 1 1
EPM2A NNAT 0 0 455 464 1 1
EPM2A TRIB1 0 0 0 171 1 1
EPM2A FTSJ1 0 0 147 168 1 1
EPM2A MTG1 0 0 0 182 1 1
EPM2A ENSG00000267168 0 0 0 209 1 1
EPM2A ENSG00000255863 0 0 0 151 1 1
EPM2A SPOPL 0 0 0 218 1 1
EPM2A NLE1 0 0 0 174 1 1
EPM2A PLEKHH3 0 0 0 175 1 1
EPM2A ENSG00000272822 0 0 0 151 1 1
EPM2A PPEF1 0 0 0 153 1 1
EPM2A ARL17A 0 0 0 151 1 1
EPM2A YWHAG 0 0 0 189 1 1
EPM2A CDK6 0 0 0 193 1 2
EPM2A RPL6 0 0 0 202 1 1
EPM2A FBXO28 0 0 181 192 1 1
EPM2A PTPRJ 0 0 118 164 1 1
EPM2A PKIG 0 0 218 218 1 1
EPM2A LLGL1 0 0 0 194 1 1
EPM2A RHOB 0 0 0 155 1 1
EPM2A CUX1 0 0 0 188 1 1
EPM2A MRPL13 0 0 0 166 1 1
EPM2A GAA 0 0 370 404 1 2
EPM2A PRKCE 0 0 0 175 1 1
EPM2A TAF1C 0 0 388 388 1 1
EPM2A PSTPIP1 0 0 0 172 1 1
EPM2A CDK4 0 0 0 193 1 2
EPM2A METAP2 0 0 0 185 1 1
EPM2A RPS16 0 0 0 151 1 1
EPM2A GNL3 0 0 0 305 1 1
EPM2A HSPBP1 0 0 92 182 1 1
EPM2A ARF5 0 0 0 151 1 1
EPM2A PAK1 0 0 0 157 1 2
EPM2A TRIM23 0 0 0 155 1 1
EPM2A C1QTNF7 0 0 217 217 1 1
EPM2A NSA2 0 0 0 240 1 1
EPM2A GNL3L 0 0 0 305 1 1
EPM2A CDK14 0 0 0 193 1 1
EPM2A MED29 0 0 0 330 1 1
EPM2A MYC 0 0 457 481 1 2
EPM2A HIPK1 0 0 0 180 1 1
EPM2A ARL8B 0 0 0 151 1 1
EPM2A CAPN3 0 0 249 301 1 1
EPM2A CIB3 0 0 0 158 1 1
EPM2A UBE2D1 0 0 184 247 1 1
EPM2A CIB2 0 0 0 158 1 1
EPM2A TAB1 0 0 0 219 1 1
EPM2A PPP3CB 0 0 0 297 1 1
EPM2A MYH10 0 0 0 167 1 1
EPM2A MSRA 0 0 206 206 1 1
EPM2A NDFIP2 0 0 0 155 1 1
EPM2A TCTA 0 0 99 161 1 1
EPM2A RGL1 0 0 243 242 1 1
EPM2A PPP3CC 0 0 0 297 1 1
EPM2A UBA1 270 0 0 285 1 1
EPM2A PTPMT1 0 0 520 650 1 1
EPM2A HIPK4 0 0 0 180 1 1
EPM2A PARK7 0 0 125 255 1 2
EPM2A STXBP6 0 0 0 194 1 1
EPM2A NHLRC2 0 0 232 322 1 1
EPM2A PAK7 0 0 0 157 1 1
EPM2A MAP2K5 0 0 0 257 1 1
EPM2A ENSG00000272772 0 0 0 285 1 1
EPM2A PFKM 0 0 150 217 1 1
EPM2A RBCK1 0 0 134 154 1 1
EPM2A MAP2K1 0 0 0 257 1 1
EPM2A METTL23 0 0 0 209 1 1
EPM2A MAPK4 0 0 0 291 1 1
EPM2A DUSP15 0 0 195 195 1 1
EPM2A ARF1 0 0 0 151 1 1
EPM2A HSPA1L 0 0 0 161 1 1
EPM2A COX5A 192 0 0 192 1 1
EPM2A MYH3 0 0 0 156 1 1
EPM2A PDP2 0 0 0 204 1 1
EPM2A ENSG00000258472 0 0 0 175 1 1
EPM2A PLK1 0 0 0 219 1 2
EPM2A TOM1 0 0 0 183 1 1
EPM2A FBXO42 0 0 207 236 1 1
EPM2A TSNARE1 0 0 75 158 1 1
EPM2A TRIM72 0 0 113 150 1 1
EPM2A CLCN2 0 0 136 155 1 1
EPM2A MYO1D 0 0 0 165 1 1
EPM2A TUBB4A 0 0 112 173 1 1
EPM2A PPP1R3E 0 0 241 283 1 1
EPM2A TOPORS 192 0 0 202 1 1
EPM2A RADIL 0 0 0 156 1 1
EPM2A PTPN9 0 0 391 422 1 1
EPM2A PYGL 0 0 119 161 1 1
EPM2A SIRT5 0 0 0 156 1 1
EPM2A CLN3 0 0 159 197 1 2
EPM2A MAPK13 0 0 0 291 1 1
EPM2A CDK2 0 0 0 193 1 2
EPM2A SCN1A 0 0 167 200 1 1
EPM2A PIDD1 0 0 0 166 1 1
EPM2A MAST1 0 0 0 251 1 1
EPM2A RPL14 0 0 0 203 1 1
EPM2A PTPN13 0 0 324 361 1 1
EPM2A RHOU 0 0 0 155 1 1
EPM2A ATF7-NPFF 0 0 0 168 1 1
EPM2A MYO9B 0 0 0 192 1 1
EPM2A MYO5A 0 0 0 156 1 1
EPM2A RPL13A 0 0 0 229 1 1
EPM2A MYO1H 0 0 0 165 1 1
EPM2A CALM1 0 0 73 177 1 1
EPM2A RAB12 0 0 0 164 1 2
EPM2A FRAT2 0 0 436 436 1 1
EPM2A BATF2 0 0 0 168 1 1
EPM2A PTPRB 0 0 96 264 1 1
EPM2A MYO19 0 0 0 156 1 1
EPM2A RPS27A 0 900 0 905 1 1
EPM2A PPP6C 0 0 45 262 1 1
EPM2A GSK3B 270 0 458 652 1 2
EPM2A DUSP2 0 0 166 445 1 1
EPM2A NTF3 0 0 296 297 1 1
EPM2A PNPLA3 0 0 66 236 1 1
EPM2A POLR3A 0 0 0 156 1 1
EPM2A KCNQ3 0 0 74 158 1 1
EPM2A RANBP6 0 0 0 166 1 1
EPM2A SRPK3 0 0 0 169 1 1
EPM2A MAPK15 0 0 0 291 1 1
EPM2A C18orf32 0 0 0 190 1 1
EPM2A PTS 0 0 507 507 1 1
EPM2A ENSG00000268643 0 0 0 193 1 1
EPM2A PLA2G6 0 0 0 189 1 1
EPM2A GYG1 0 600 688 873 1 1
EPM2A MYH7 0 0 0 156 1 1
EPM2A PAK4 0 0 0 157 1 1
EPM2A AMY2B 0 0 123 197 1 1
EPM2A CDC25A 0 0 0 210 1 1
EPM2A RHOBTB3 0 0 0 155 1 1
EPM2A PES1 0 0 0 178 1 1
EPM2A MYH11 0 0 0 156 1 1
EPM2A CTDNEP1 0 0 167 213 1 1
EPM2A MYO16 0 0 0 156 1 1
EPM2A BECN1 0 0 96 172 1 2
EPM2A MAPT 0 0 330 330 1 2
EPM2A GYS1 312 600 764 932 1 1
EPM2A DUSP1 0 0 320 424 1 1
EPM2A NCCRP1 0 0 0 177 1 1
EPM2A MAPK11 0 0 0 291 1 1
EPM2A RPL23A 0 0 0 247 1 1
EPM2A PKN2 0 0 91 218 1 1
EPM2A DTX2 0 0 148 189 1 1
EPM2A RND2 0 0 0 155 1 1
EPM2A TSSK4 0 0 0 171 1 1
EPM2A GAS7 0 0 0 225 1 1
EPM2A SYNPO2 0 0 113 243 1 1
EPM2A DUSP27 0 0 323 323 1 1
EPM2A RHOD 0 0 0 155 1 1
EPM2A PPP1R3F 0 0 155 154 1 1
EPM2A MYO1C 0 0 0 165 1 1
EPM2A UBC 0 900 0 907 1 2
EPM2A SGIP1 0 0 0 172 1 1
EPM2A IPO4 0 0 0 166 1 1
EPM2A AGL 0 0 752 758 1 1
EPM2A VAV1 0 0 398 409 1 1
EPM2A KLHL23 0 0 92 164 1 1
EPM2A MYH15 0 0 0 156 1 1
EPM2A RPL5 0 0 0 300 1 1
EPM2A CLK2 0 0 0 247 1 1
EPM2A PTP4A1 0 0 76 155 1 1
EPM2A PLAA 0 0 43 245 1 1
EPM2A PKN1 0 0 0 175 1 1
EPM2A PLK3 0 0 0 219 1 1
EPM2A CDC25B 0 0 0 210 1 1
EPM2A PKN3 0 0 0 175 1 1
EPM2A RIPK4 0 0 0 192 1 1
EPM2A OPTN 0 0 435 435 1 2
EPM2A PIM2 0 0 0 171 1 1
EPM2A UBE2D2 0 0 103 200 1 1
EPM2A FLYWCH2 0 0 120 270 1 1
EPM2A MRPL2 0 0 0 161 1 1
EPM2A RPL23 0 0 0 196 1 1
EPM2A RPL27A 0 0 0 230 1 1
EPM2A PTPRA 0 0 469 515 1 1
EPM2A ILKAP 0 0 0 219 1 1
EPM2A MYO7A 0 0 0 175 1 1
EPM2A DUSP28 0 0 183 183 1 1
EPM2A STK40 0 0 0 171 1 1
EPM2A ZNF593 0 0 0 179 1 1
EPM2A PSMC3 192 0 0 192 1 1
EPM2A DOCK4 0 0 0 220 1 1
EPM2A KLHL34 0 0 94 172 1 1
EPM2A TSSK6 0 0 60 188 1 1
EPM2A ENSG00000273398 0 0 0 166 1 1
EPM2A RPL34 0 0 44 204 1 1
EPM2A CLN6 0 0 150 227 1 1
EPM2A DIRC3 0 0 0 201 1 1
EPM2A PPP4R4 0 0 0 177 1 1
EPM2A TRIM32 0 0 293 582 1 1
EPM2A C6orf211 0 0 0 189 1 1
EPM2A PRICKLE2 0 0 294 305 1 1
EPM2A PPP3R1 0 0 0 166 1 1
EPM2A PA2G4 0 0 0 366 1 1
EPM2A ASPM 0 0 0 170 1 1
EPM2A IRAK4 0 0 0 153 1 1
EPM2A PALD1 0 0 54 159 1 1
EPM2A FOSB 0 0 0 168 1 1
EPM2A UTP23 0 0 0 151 1 1
EPM2A FBXO30 0 0 604 771 1 1
EPM2A FOSL2 0 0 0 168 1 1
EPM2A DYRK1B 0 0 0 180 1 1
EPM2A SGK1 0 0 158 252 1 2
EPM2A DDX52 0 0 0 152 1 1
EPM2A SCAI 0 0 90 159 1 1
EPM2A CDK1 0 0 0 193 1 2
EPM2A STBD1 691 0 698 903 1 1
EPM2A RPS6KB1 0 0 67 172 1 2
EPM2A MYO6 0 0 0 156 1 1
EPM2A PPP1R3B 0 0 330 682 1 1
EPM2A DVL2 0 0 202 243 1 2
EPM2A MYO18A 0 0 0 156 1 1
EPM2A PTPN2 0 0 325 383 1 2
EPM2A ITSN1 0 0 0 167 1 1
EPM2A RNASEL 0 0 0 181 1 1
EPM2A AARS 0 0 0 195 1 1
EPM2A CLN5 0 0 180 224 1 1
EPM2A DUSP6 0 0 181 404 1 1
EPM2A FCHO1 0 0 0 172 1 1
EPM2A TDG 192 0 0 198 1 1
EPM2A RPL18 0 0 0 204 1 1
EPM2A KBTBD12 0 0 120 190 1 1
EPM2A MRPL15 0 0 0 165 1 1
EPM2A PRC1 0 0 0 219 1 1
EPM2A ASB15 0 0 74 166 1 1
EPM2A MYO18B 0 0 0 156 1 1
EPM2A RBFOX3 0 0 123 161 1 1
EPM2A CDK3 0 0 0 193 1 1
EPM2A RPL39L 0 0 0 195 1 1
EPM2A ATP13A2 0 0 67 152 1 1
EPM2A RPL7A 0 0 0 214 1 1
EPM2A SSU72 0 0 164 293 1 1
EPM2A RND3 0 0 0 155 1 1
EPM2A MRTO4 0 0 0 286 1 1
EPM2A MAP3K14 0 0 0 207 1 1
EPM2A RHOF 0 0 0 155 1 1
EPM2A TAF5 0 0 0 165 1 1
EPM2A ATF3 0 0 0 168 1 2
EPM2A ENSG00000142539 0 0 0 180 1 1
EPM2A RHOC 0 0 0 155 1 1
EPM2A RPL7L1 0 0 0 201 1 1
EPM2A MYO1A 0 0 0 165 1 1
EPM2A GSK3A 0 0 415 507 1 1
EPM2A SIRT4 0 0 0 156 1 1
EPM2A AP1S2 0 0 144 177 1 1
EPM2A WWOX 0 0 391 390 1 1
EPM2A RASIP1 0 0 0 156 1 1
EPM2A HMGXB4 192 0 0 331 1 1
EPM2A GYS2 0 600 422 769 1 1
EPM2A ENSG00000274276 0 0 163 177 1 1
EPM2A CDK15 0 0 0 193 1 1
EPM2A GFPT2 0 0 0 175 1 1
EPM2A MAP3K1 0 0 0 207 1 1
EPM2A ARL15 0 0 0 151 1 1
EPM2A SGK3 0 0 0 167 1 1
EPM2A UBLCP1 0 0 181 367 1 1
EPM2A DUSP23 0 0 600 606 1 1
EPM2A ARL5A 0 0 0 151 1 1
EPM2A AKT1 0 0 134 216 1 2
EPM2A UBE3A 0 0 90 214 1 1
EPM2A DISC1 0 0 321 321 1 1
EPM2A PCBP4 0 0 0 181 1 1
EPM2A RPF2 0 0 0 185 1 1
EPM2A PTPRQ 0 0 90 186 1 1
EPM2A RRP1B 0 0 161 183 1 1
EPM2A PTPN7 0 0 460 506 1 1
EPM2A PIAS4 0 0 154 174 1 1
EPM2A GPCPD1 0 0 194 199 1 1
EPM2A LRRK1 0 0 0 209 1 1
EPM2A RHOH 0 0 0 155 1 1
EPM2A HEXIM1 270 0 0 280 1 1
EPM2A DUSP11 0 0 261 654 1 1
EPM2A PPM1D 0 0 0 219 1 1
EPM2A HACE1 0 0 0 167 1 1
EPM2A TRRAP 0 0 0 150 1 1
EPM2A GPN2 0 0 0 153 1 1
EPM2A SLK 0 0 282 282 1 1
EPM2A RAB25 0 0 111 213 1 2
EPM2A YWHAB 0 0 0 189 1 1
EPM2A CUX2 0 0 0 188 1 1
EPM2A CREB5 0 0 0 168 1 1
EPM2A PPP4R1 0 0 0 177 1 1
EPM2A TEN1-CDK3 0 0 0 193 1 1
EPM2A FRMPD2 0 0 0 161 1 1
EPM2A CIB1 0 0 0 166 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005515 Molecular Function protein binding enables IPI
GO:0032007 Biological Process negative regulation of TOR signaling acts_upstream_of_or_within IMP
GO:0016239 Biological Process positive regulation of macroautophagy acts_upstream_of_or_within IMP
GO:0005634 Cellular Component nucleus located_in IEA
Pathways
Name DB ID
Metabolism Reactome R-HSA-1430728
Disease Reactome R-HSA-1643685
Glycogen storage diseases Reactome R-HSA-3229121
Glycogen synthesis Reactome R-HSA-3322077
Myoclonic epilepsy of Lafora Reactome R-HSA-3785653
Diseases of carbohydrate metabolism Reactome R-HSA-5663084
Diseases of metabolism Reactome R-HSA-5668914
Metabolism of carbohydrates Reactome R-HSA-71387
Glycogen metabolism Reactome R-HSA-8982491
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_153398 2 miscRNA transcript variant 7 NC_000006 Reference
XM_024446550 2 mRNA transcript variant X1 NC_000006 Reference
XM_011536113 3 mRNA transcript variant X2 NC_000006 Reference
NM_001360064 2 mRNA transcript variant 4 NC_000006 Reference
NM_001368131 1 mRNA transcript variant 9 NC_000006 Reference
NM_001360057 2 mRNA transcript variant 3 NC_000006 Reference
NM_001018041 2 mRNA transcript variant 2 NC_000006 Reference
NM_005670 4 mRNA transcript variant 1 NC_000006 Reference
NM_001368129 2 mRNA transcript variant 6 NC_000006 Reference
NM_001360071 2 mRNA transcript variant 5 NC_000006 Reference
XM_024446551 2 mRNA transcript variant X5 NC_000006 Reference
XM_011536116 2 mRNA transcript variant X4 NC_000006 Reference
NM_001368132 1 mRNA transcript variant 10 NC_000006 Reference
XM_047419364 1 mRNA transcript variant X7 NC_000006 Reference
XM_017011302 2 mRNA transcript variant X6 NC_000006 Reference
XM_047419363 1 mRNA transcript variant X3 NC_000006 Reference
NM_001368130 1 mRNA transcript variant 8 NC_000006 Reference