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MUL1

mitochondrial E3 ubiquitin protein ligase 1
General Information
Name mitochondrial E3 ubiquitin protein ligase 1
Alias
  • mitochondrial ubiquitin ligase activator of NFKB 1
  • E3 SUMO-protein ligase MUL1
  • E3 ubiquitin ligase
  • E3 ubiquitin-protein ligase MUL1
  • RING-type E3 ubiquitin transferase NFKB 1
  • growth inhibition and death E3 ligase
  • mitochondria-anchored protein ligase
  • mitochondrial E3 ubiquitin ligase 1
  • mitochondrial ubiquitin ligase activator of NF-kB
  • mitochondrial-anchored protein ligase
  • protein Hades
  • putative NF-kappa-B-activating protein 266
  • ring finger protein 218
Gene_family Ring finger proteins
organism Homo sapiens
entrez_id 79594
location 1p36.12
transcript_count 2
exon_count 4
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Enables several functions, including p53 binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including negative regulation of defense response; positive regulation of cellular protein metabolic process; and regulation of mitochondrion organization. Located in several cellular components, including mitochondrion; neuronal cell body; and peroxisome. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Stringdb Mitochondrial ubiquitin ligase activator of NFKB 1; Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the con [...]
    nextProt Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion (PubMed:21597459). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response (PubMed:23399697). Can mediate RIGI sumoylation and disrupt its polyubiquitination (PubMed:23399697).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
MUL1 BioGRID CCNF GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID HERC5 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID UBE2D2 GeneID BioGRID Co-crystal Structure; Reconstituted Complex; Two-hybrid
MUL1 BioGRID TP53 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex
MUL1 BioGRID ATRIP GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID INSC GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID SLC39A12 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID IQCF1 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID SAAL1 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID ARMC6 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID COG7 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID CCDC142 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID RANBP17 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID PBXIP1 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID SCN3B GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID SLC39A4 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID HAUS7 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID PPP4R1L GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID TTC12 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID ERAP1 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID NELFCD GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID IPO11 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID GEMIN4 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID TRHDE GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID BZW2 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID STK36 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID RANBP6 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID COG4 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID TBC1D9 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID CUL9 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID TBC1D8 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID TUBGCP3 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID CPQ GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID DGCR2 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID DOP1B GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID DOCK4 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID PPP6R2 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID SLC5A6 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID DNAH17 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID CXCR4 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID TSC2 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID PEX19 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID PDE6B GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID GPR17 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID GPC3 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID GSDME GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID CNGA3 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID ATP2A1 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID ATP1A1 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
MUL1 BioGRID AKAP1 GeneID BioGRID Proximity Label-MS
MUL1 BioGRID ORF7b GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID ORF7b GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID MUL1 GeneID BioGRID Biochemical Activity
MUL1 BioGRID UBE2D1 GeneID BioGRID Reconstituted Complex; Two-hybrid
MUL1 BioGRID HSCB GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID UBXN7 GeneID BioGRID Biochemical Activity
MUL1 BioGRID UBE2E3 GeneID BioGRID Reconstituted Complex; Two-hybrid
MUL1 BioGRID RANGAP1 GeneID BioGRID Biochemical Activity
MUL1 BioGRID UBE2D3 GeneID BioGRID Reconstituted Complex; Two-hybrid
MUL1 BioGRID KRTAP10-8 GeneID BioGRID Two-hybrid
MUL1 BioGRID REEP2 GeneID BioGRID Two-hybrid
MUL1 BioGRID APPBP2 GeneID BioGRID Two-hybrid
MUL1 BioGRID LMBR1L GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID Dppa3 GeneID BioGRID Proximity Label-MS
MUL1 BioGRID MAD2L2 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID VCP GeneID BioGRID Affinity Capture-Western
MUL1 BioGRID ANKFY1 GeneID BioGRID Affinity Capture-Western
MUL1 BioGRID EHD1 GeneID BioGRID Reconstituted Complex
MUL1 BioGRID VPS26A GeneID BioGRID Affinity Capture-Western
MUL1 BioGRID SLC25A46 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
MUL1 BioGRID STING1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
MUL1 BioGRID UBE2R2 GeneID BioGRID Reconstituted Complex
MUL1 BioGRID UBE2D4 GeneID BioGRID Reconstituted Complex; Two-hybrid
MUL1 BioGRID UBE2V2 GeneID BioGRID Reconstituted Complex
MUL1 BioGRID UBE2N GeneID BioGRID Reconstituted Complex
MUL1 BioGRID UBE2E1 GeneID BioGRID Reconstituted Complex; Two-hybrid
MUL1 BioGRID CDC34 GeneID BioGRID Reconstituted Complex
MUL1 BioGRID GUCY1B1 GeneID BioGRID Affinity Capture-MS
MUL1 BioGRID MAP3K7 GeneID BioGRID Reconstituted Complex
MUL1 BioGRID HTRA2 GeneID BioGRID Biochemical Activity
MUL1 BioGRID TP73 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
MUL1 BioGRID ATG13 GeneID BioGRID Affinity Capture-Western
MUL1 BioGRID ULK1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MUL1 BioGRID UBC GeneID BioGRID Biochemical Activity
MUL1 BioGRID UBE2L3 GeneID BioGRID Two-hybrid
MUL1 BioGRID UBE2G2 GeneID BioGRID Two-hybrid
MUL1 BioGRID UBE2E2 GeneID BioGRID Two-hybrid
MUL1 BioGRID TRIM9 GeneID BioGRID Two-hybrid
MUL1 BioGRID GABARAP GeneID BioGRID Affinity Capture-Western
MUL1 BioGRID TRAF2 GeneID BioGRID Affinity Capture-Western
MUL1 BioGRID TAP1 GeneID BioGRID Two-hybrid
MUL1 BioGRID MAVS GeneID BioGRID Affinity Capture-Western
MUL1 BioGRID AKT1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MUL1 BioGRID DNM1L GeneID BioGRID Biochemical Activity
MUL1 BioGRID SUMO1 GeneID BioGRID Biochemical Activity
MUL1 BioGRID UBE2I GeneID BioGRID Affinity Capture-Western
MUL1 BioGRID VPS35 GeneID BioGRID Affinity Capture-Western
MUL1 BioGRID UBE2U GeneID BioGRID Two-hybrid
MUL1 BioGRID UBE2W GeneID BioGRID Two-hybrid
MUL1 BioGRID UBE2L6 GeneID BioGRID Two-hybrid
MUL1 Protein APPBP2 GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
MUL1 BNIP3 0 0 517 599 1 2
MUL1 SQSTM1 0 0 348 347 1 2
MUL1 TRIM73 0 0 161 167 1 1
MUL1 MKRN2 0 0 129 168 1 1
MUL1 HP1BP3 0 0 111 187 1 1
MUL1 TRIM56 0 0 323 323 1 1
MUL1 RNF5 0 0 337 414 1 1
MUL1 ENO3 0 0 0 189 1 1
MUL1 SIRT3 0 0 161 179 1 2
MUL1 OMA1 0 0 421 420 1 1
MUL1 RNF151 0 0 175 207 1 1
MUL1 CAMK2N2 0 0 0 254 1 1
MUL1 NLRX1 0 0 203 251 1 2
MUL1 STUB1 0 0 243 344 1 2
MUL1 SPG7 0 0 181 224 1 1
MUL1 CPD 0 0 0 190 1 1
MUL1 ATG12 0 0 219 244 1 2
MUL1 ATG13 270 0 203 407 1 2
MUL1 UBE2E1 500 0 187 691 1 1
MUL1 ACTB 0 0 123 183 1 2
MUL1 COX4I1 0 0 134 175 1 1
MUL1 RANGAP1 270 0 138 343 1 1
MUL1 FBXO27 0 0 234 234 1 1
MUL1 TP73 270 0 0 270 1 2
MUL1 VPS29 0 0 336 350 1 1
MUL1 HTRA2 270 0 235 421 1 1
MUL1 SMURF1 0 0 391 479 1 1
MUL1 MARCH9 0 0 167 188 1 1
MUL1 DESI1 0 0 134 153 1 1
MUL1 RNF152 0 0 168 173 1 1
MUL1 NLRP3 0 0 210 210 1 2
MUL1 BZW1 0 0 0 158 1 1
MUL1 TFEB 0 0 149 243 1 2
MUL1 LARGE 0 0 123 274 1 1
MUL1 GABARAPL1 0 0 324 337 1 2
MUL1 TMEM135 0 0 166 235 1 1
MUL1 PHB2 0 0 294 376 1 1
MUL1 RNF150 0 0 258 310 1 1
MUL1 AKAP1 0 0 147 153 1 1
MUL1 TFB2M 0 0 143 196 1 1
MUL1 GOLGA1 0 0 122 157 1 1
MUL1 MID1 0 0 96 187 1 1
MUL1 TRIM68 0 0 195 253 1 1
MUL1 SENP6 0 0 232 231 1 1
MUL1 TRIM31 0 0 261 261 1 1
MUL1 ECSIT 0 0 72 173 1 1
MUL1 UBE2L6 192 0 92 244 1 1
MUL1 FGF9 0 0 0 207 1 1
MUL1 ATG16L1 0 0 75 174 1 2
MUL1 UBE2G2 192 0 47 197 1 1
MUL1 FBXO17 0 0 150 205 1 1
MUL1 MAT2B 0 900 0 900 1 1
MUL1 UBE2N 270 0 172 394 1 1
MUL1 TOMM40 0 0 161 199 1 1
MUL1 DEF8 0 0 134 173 1 1
MUL1 AR 0 0 75 150 1 2
MUL1 UBE2L3 192 0 181 339 1 1
MUL1 RPS27A 270 0 0 280 1 1
MUL1 PI4K2A 0 0 108 151 1 1
MUL1 ZNF746 0 0 335 335 1 1
MUL1 CDC34 270 0 93 345 1 1
MUL1 SLC25A46 270 0 194 386 1 1
MUL1 FOXO1 0 0 251 250 1 2
MUL1 ARMC6 183 0 0 183 1 1
MUL1 TFAM 0 0 285 301 1 2
MUL1 COIL 0 0 0 258 1 2
MUL1 EI24 0 0 193 234 1 2
MUL1 RNF122 0 0 203 221 1 1
MUL1 PLA2G2F 0 0 134 289 1 1
MUL1 SYNJ2BP 0 0 122 197 1 1
MUL1 DNM1 0 0 181 256 1 1
MUL1 MFN1 0 0 602 695 1 2
MUL1 SH3RF2 0 0 129 168 1 1
MUL1 MID2 0 0 122 176 1 1
MUL1 SENP7 0 0 323 323 1 1
MUL1 CCDC182 0 0 134 222 1 1
MUL1 RING1 0 0 180 213 1 1
MUL1 SAE1 0 0 220 220 1 1
MUL1 FUNDC1 0 0 556 559 1 2
MUL1 HAUS7 208 0 0 208 1 1
MUL1 ANKIB1 0 0 134 171 1 1
MUL1 RNF13 0 0 182 199 1 1
MUL1 ARIH1 0 0 402 486 1 1
MUL1 ZNRF2 0 0 218 218 1 1
MUL1 TTC3 0 0 460 503 1 1
MUL1 SOD1 0 0 163 176 1 2
MUL1 TBL1X 0 0 90 155 1 1
MUL1 SLC16A14 0 0 0 204 1 1
MUL1 DTX4 0 0 138 171 1 1
MUL1 MSTN 0 0 192 209 1 1
MUL1 ATAD2 0 0 0 214 1 1
MUL1 CPZ 0 0 122 470 1 1
MUL1 RNF182 0 0 164 170 1 1
MUL1 VCP 154 0 244 374 1 2
MUL1 MGRN1 0 0 203 231 1 1
MUL1 ARID5A 0 0 0 223 1 1
MUL1 RHOT1 0 900 391 939 1 1
MUL1 RMND5B 0 0 154 153 1 1
MUL1 TRIM11 0 0 122 152 1 1
MUL1 UBE2E3 680 0 235 774 1 1
MUL1 RNF20 0 0 141 171 1 1
MUL1 TMEM173 270 0 194 386 1 1
MUL1 PNMA5 0 0 180 179 1 1
MUL1 RNF141 0 0 150 200 1 1
MUL1 TMTC4 0 0 212 212 1 1
MUL1 APIP 0 0 0 156 1 1
MUL1 TRIM17 0 0 165 180 1 1
MUL1 LONP2 0 0 104 157 1 1
MUL1 FBXO4 0 0 134 255 1 1
MUL1 AMFR 0 0 465 471 1 1
MUL1 KIAA0226L 0 0 218 218 1 1
MUL1 SLC16A4 0 0 0 330 1 1
MUL1 DNAJA3 0 0 107 150 1 1
MUL1 PIAS1 0 0 166 165 1 1
MUL1 TLR2 0 0 257 257 1 2
MUL1 RNF208 0 0 166 165 1 1
MUL1 PEX3 0 0 310 309 1 2
MUL1 SRF 0 0 62 164 1 1
MUL1 ERF 0 0 0 274 1 1
MUL1 ULK2 0 0 154 153 1 2
MUL1 USP35 0 0 154 153 1 1
MUL1 PHB 0 0 129 154 1 1
MUL1 TRAF3 0 0 143 181 1 2
MUL1 LRRK2 0 0 285 355 1 2
MUL1 APPBP2 474 0 0 474 1 1
MUL1 ZSWIM2 0 0 136 175 1 1
MUL1 SHC4 0 0 107 162 1 1
MUL1 SLC39A4 209 0 0 209 1 1
MUL1 BECN1 0 0 318 367 1 2
MUL1 TRIM38 0 0 269 269 1 1
MUL1 SNCA 0 0 268 300 1 2
MUL1 NR6A1 0 0 932 941 1 1
MUL1 RNF130 0 0 204 222 1 1
MUL1 COX4I2 0 0 167 192 1 1
MUL1 CGRRF1 0 0 159 188 1 1
MUL1 STOM 0 0 113 176 1 1
MUL1 RNF113B 0 0 161 161 1 1
MUL1 ARID5B 0 0 0 190 1 1
MUL1 PJA2 0 0 142 176 1 1
MUL1 SENP1 0 0 208 208 1 1
MUL1 SLC25A17 0 0 209 209 1 1
MUL1 PDZRN3 0 0 120 179 1 1
MUL1 SIRT1 0 0 155 154 1 2
MUL1 HECTD3 0 0 163 195 1 1
MUL1 MCL1 0 0 171 171 1 2
MUL1 RNF144B 0 0 277 321 1 1
MUL1 OPTN 0 0 413 412 1 2
MUL1 TBC1D15 0 0 194 217 1 1
MUL1 SENP3 0 0 324 340 1 1
MUL1 TRAF6 0 0 218 248 1 2
MUL1 CYCS 0 0 294 307 1 2
MUL1 UBE2D2 761 0 796 949 1 1
MUL1 IMMT 0 0 231 230 1 1
MUL1 ATAD1 0 0 261 266 1 1
MUL1 AFG3L2 0 0 155 232 1 1
MUL1 CHKB 0 0 150 682 1 1
MUL1 TRIML1 0 0 135 189 1 1
MUL1 CALCOCO2 0 0 413 412 1 2
MUL1 ATG5 0 0 323 369 1 2
MUL1 TBC1D5 0 0 108 163 1 2
MUL1 YIPF1 0 0 126 155 1 1
MUL1 FBXO7 0 0 227 226 1 1
MUL1 PXMP2 0 0 74 216 1 1
MUL1 RNF148 0 0 184 189 1 1
MUL1 TRIM55 0 0 164 175 1 1
MUL1 MIEF1 0 0 466 482 1 1
MUL1 NIPSNAP1 0 0 117 209 1 1
MUL1 UBE4B 0 0 167 194 1 1
MUL1 TRIM35 0 0 126 162 1 1
MUL1 ENY2 0 0 0 248 1 1
MUL1 TXNL4B 0 0 0 190 1 1
MUL1 PMPCB 0 0 98 247 1 1
MUL1 USP30 0 600 595 879 1 1
MUL1 CHKA 0 0 0 609 1 1
MUL1 UBC 270 0 0 294 1 2
MUL1 PIAS3 0 0 183 183 1 1
MUL1 CDK5RAP1 0 0 0 217 1 1
MUL1 MAP1LC3B 0 0 325 349 1 2
MUL1 NDUFS7 0 0 0 181 1 1
MUL1 NUFIP1 0 0 156 155 1 1
MUL1 TULP2 0 0 53 259 1 1
MUL1 ULK1 270 0 257 434 1 2
MUL1 ENO2 0 0 0 250 1 1
MUL1 MT-CO1 0 0 108 175 1 1
MUL1 FBXO40 0 0 335 402 1 1
MUL1 PEX5 0 0 143 221 1 1
MUL1 RARA 0 0 57 158 1 2
MUL1 SH3BP5L 0 0 156 178 1 1
MUL1 MARCH3 0 0 144 183 1 1
MUL1 OSBPL9 0 0 108 201 1 1
MUL1 BCL2L13 0 0 374 451 1 2
MUL1 VPS35 270 0 638 766 1 2
MUL1 RNF26 0 0 345 384 1 1
MUL1 SLC39A12 189 0 0 189 1 1
MUL1 TRIM63 0 0 391 404 1 1
MUL1 EIF3F 0 0 150 173 1 1
MUL1 TRIM21 0 0 134 198 1 1
MUL1 TOMM70A 0 900 284 925 1 1
MUL1 MB21D1 0 0 204 204 1 1
MUL1 VPS26A 486 0 536 757 1 1
MUL1 TRIM32 0 0 360 360 1 1
MUL1 UBE2D4 500 0 48 575 1 1
MUL1 ACTC1 0 0 0 294 1 1
MUL1 SAMM50 0 0 99 225 1 1
MUL1 RNF220 0 0 120 160 1 1
MUL1 TRIM54 0 0 180 191 1 1
MUL1 DDX41 0 0 134 226 1 1
MUL1 DDX58 0 0 218 218 1 1
MUL1 AIM2 0 0 155 154 1 2
MUL1 MAVS 270 0 483 607 1 2
MUL1 DMD 0 0 97 235 1 2
MUL1 DNM2 0 0 103 188 1 1
MUL1 LONRF3 0 0 137 176 1 1
MUL1 TRAT1 0 0 186 218 1 1
MUL1 TRIM46 0 0 126 163 1 1
MUL1 ATG7 0 0 242 251 1 2
MUL1 AREL1 0 0 134 186 1 1
MUL1 SYNGR4 0 0 65 278 1 1
MUL1 PSMB7 0 0 95 170 1 1
MUL1 RNF128 0 0 144 174 1 1
MUL1 MIEF2 0 0 505 518 1 1
MUL1 GTPBP1 0 0 0 281 1 1
MUL1 ZFPL1 0 0 161 186 1 1
MUL1 CNTLN 0 0 0 243 1 1
MUL1 UBE2U 192 0 195 389 1 1
MUL1 TXN2 0 0 0 175 1 1
MUL1 GABARAP 270 0 469 604 1 2
MUL1 PTEN 0 0 181 198 1 2
MUL1 FBXL2 0 0 180 179 1 1
MUL1 VPS26B 0 0 181 199 1 1
MUL1 HECW2 0 0 243 259 1 1
MUL1 UBXN2B 0 0 60 156 1 1
MUL1 ENOPH1 0 0 0 156 1 1
MUL1 TRIM41 0 0 141 175 1 1
MUL1 MYOD1 0 0 135 165 1 1
MUL1 RNF44 0 0 162 181 1 1
MUL1 DNM1L 270 0 612 742 1 2
MUL1 TRAF7 0 0 167 216 1 1
MUL1 RNF207 0 0 127 181 1 1
MUL1 TRIM47 0 0 97 155 1 1
MUL1 UBAP2 0 0 120 160 1 1
MUL1 CAMK2N1 0 0 86 581 1 1
MUL1 GADD45GIP1 0 0 97 161 1 1
MUL1 RC3H1 0 0 118 308 1 1
MUL1 RNF157 0 0 134 171 1 1
MUL1 RNF183 0 0 244 243 1 1
MUL1 ATAD2B 0 0 0 237 1 1
MUL1 AMBRA1 0 0 375 375 1 2
MUL1 SNCAIP 0 0 261 261 1 2
MUL1 UBOX5 0 0 233 295 1 1
MUL1 NFE2L1 0 0 96 216 1 1
MUL1 UBR3 0 0 189 313 1 1
MUL1 RHOT2 0 0 287 328 1 1
MUL1 UBE2M 0 0 113 184 1 1
MUL1 PEX12 0 0 145 276 1 1
MUL1 CDK5 0 0 91 273 1 2
MUL1 TRIM67 0 0 123 163 1 1
MUL1 NFXL1 0 0 125 183 1 1
MUL1 DNAJC11 0 0 138 159 1 1
MUL1 NPY1R 0 0 0 290 1 1
MUL1 WSB2 0 0 218 218 1 1
MUL1 HUWE1 0 0 401 400 1 1
MUL1 POLG2 0 0 89 180 1 1
MUL1 MLC1 0 0 270 270 1 1
MUL1 SENP5 0 0 560 560 1 1
MUL1 UBE4A 0 0 167 194 1 1
MUL1 REEP2 160 0 0 161 1 1
MUL1 ZFYVE19 0 0 136 175 1 1
MUL1 CISD2 0 0 216 247 1 2
MUL1 THAP4 0 0 0 201 1 1
MUL1 MTCH1 0 0 212 229 1 1
MUL1 DCST1 0 0 152 167 1 1
MUL1 LTN1 0 0 167 167 1 1
MUL1 KIAA0196 0 0 170 183 1 1
MUL1 HSCB 270 0 0 270 1 1
MUL1 ZFAND4 0 0 181 270 1 1
MUL1 RHEB 0 0 138 150 1 2
MUL1 UBFD1 0 0 157 173 1 1
MUL1 NSMCE2 0 0 142 331 1 1
MUL1 MKKS 0 0 74 157 1 1
MUL1 VDAC2 0 900 125 916 1 1
MUL1 CANX 0 0 150 173 1 2
MUL1 CD300C 0 0 330 330 1 1
MUL1 NDUFB5 0 0 0 252 1 1
MUL1 PID1 0 0 0 302 1 1
MUL1 USP13 0 0 203 203 1 1
MUL1 FAF2 0 0 103 308 1 1
MUL1 SIVA1 0 0 86 196 1 1
MUL1 INF2 0 0 178 177 1 1
MUL1 TRIM23 0 0 134 199 1 1
MUL1 TRIM42 0 0 180 180 1 1
MUL1 MARCH1 0 0 164 202 1 1
MUL1 PMPCA 0 0 0 166 1 1
MUL1 IDE 0 900 0 907 1 1
MUL1 CAT 0 0 185 185 1 2
MUL1 CHCHD2 0 0 150 247 1 1
MUL1 ANKFY1 270 0 193 385 1 1
MUL1 CDK1 0 0 140 226 1 2
MUL1 MCMBP 0 0 47 192 1 1
MUL1 HTT 0 0 181 181 1 2
MUL1 UBL4A 0 0 91 171 1 1
MUL1 TP53 818 0 643 932 1 2
MUL1 CBL 0 0 134 267 1 1
MUL1 HSPA9 0 0 206 206 1 1
MUL1 SCAI 0 0 74 645 1 1
MUL1 USP37 0 0 54 151 1 1
MUL1 INSIG1 0 0 113 188 1 1
MUL1 TRIM24 0 0 103 261 1 1
MUL1 NPY4R 0 0 0 290 1 1
MUL1 TRIM40 0 0 128 168 1 1
MUL1 TMEM50A 0 0 235 352 1 1
MUL1 UBE2I 270 0 339 496 1 1
MUL1 HSPBP1 0 0 60 160 1 1
MUL1 RNF186 0 0 125 177 1 1
MUL1 MAP3K7 270 0 0 281 1 2
MUL1 ZNHIT3 0 0 155 154 1 1
MUL1 RNF10 0 0 123 163 1 1
MUL1 PRPF19 0 0 47 173 1 1
MUL1 FAM43B 0 0 232 692 1 1
MUL1 MAP1A 0 0 96 299 1 2
MUL1 RNF170 0 0 150 201 1 1
MUL1 ACTA2 0 0 0 294 1 1
MUL1 SIAH2 0 0 135 161 1 1
MUL1 TIMM23 0 0 228 244 1 1
MUL1 RMDN3 0 0 264 342 1 1
MUL1 RNF149 0 0 171 171 1 1
MUL1 BYSL 0 0 0 209 1 1
MUL1 CPN1 0 0 0 208 1 1
MUL1 NDUFB7 0 0 57 489 1 1
MUL1 ATG4B 0 0 131 158 1 2
MUL1 PEX10 0 0 142 291 1 1
MUL1 ACTA1 0 0 88 486 1 1
MUL1 PARK7 0 0 294 455 1 2
MUL1 RNF166 0 0 162 161 1 1
MUL1 ZNRF4 0 0 246 245 1 1
MUL1 TAX1BP1 0 0 320 319 1 2
MUL1 GPS2 0 0 89 151 1 1
MUL1 USPL1 0 0 123 248 1 1
MUL1 PLEKHA4 270 0 0 270 1 1
MUL1 SNCG 0 0 0 254 1 1
MUL1 PPEF2 0 0 144 197 1 1
MUL1 UBA1 0 0 167 167 1 1
MUL1 CYSRT1 0 0 218 218 1 1
MUL1 PPIF 0 0 182 202 1 1
MUL1 OPA1 0 0 268 335 1 2
MUL1 MFF 0 0 526 526 1 1
MUL1 ST13 0 0 181 203 1 2
MUL1 RNF41 0 0 208 239 1 1
MUL1 MARCH7 0 0 190 204 1 1
MUL1 RB1CC1 0 0 170 199 1 2
MUL1 GDAP1 0 0 310 315 1 1
MUL1 NEDD4L 0 0 181 220 1 1
MUL1 PGAM5 0 0 261 347 1 1
MUL1 SCN3B 189 0 0 189 1 1
MUL1 RNF214 0 0 164 176 1 1
MUL1 ENSG00000272772 0 0 0 266 1 1
MUL1 LMBR1L 270 0 0 270 1 1
MUL1 UBE2Z 0 0 134 468 1 1
MUL1 ASMT 0 0 0 233 1 1
MUL1 CNPPD1 0 0 0 159 1 1
MUL1 RNF25 0 0 109 171 1 1
MUL1 UQCRC1 0 0 0 265 1 1
MUL1 NBR1 0 0 342 342 1 2
MUL1 PTRH2 0 900 0 902 1 1
MUL1 LONRF1 0 0 126 166 1 1
MUL1 UBE2D1 875 0 214 912 1 1
MUL1 PPARGC1A 0 0 323 324 1 2
MUL1 PCK1 0 0 0 188 1 1
MUL1 MARC2 0 0 181 181 1 1
MUL1 TANK 270 0 108 321 1 2
MUL1 PIAS2 0 0 147 186 1 1
MUL1 UBE2W 192 0 0 192 1 1
MUL1 RNF125 0 0 137 163 1 1
MUL1 PARK2 0 0 529 626 1 1
MUL1 RNF185 0 0 593 616 1 1
MUL1 VAPB 0 0 158 165 1 1
MUL1 ARIH2 0 0 219 243 1 1
MUL1 ATP13A2 0 0 167 168 1 1
MUL1 ETV3 0 0 0 256 1 1
MUL1 UBXN7 270 0 113 349 1 1
MUL1 FIS1 0 0 601 636 1 2
MUL1 ZFAND5 0 0 234 266 1 1
MUL1 TRAF2 270 0 49 304 1 2
MUL1 USP14 0 0 155 173 1 2
MUL1 TAB1 0 0 89 169 1 1
MUL1 AP4M1 0 0 227 226 1 1
MUL1 IQCF1 468 0 0 468 1 1
MUL1 G6PC 0 0 0 189 1 1
MUL1 TRIM74 0 0 175 181 1 1
MUL1 USP15 0 0 155 169 1 1
MUL1 RNF135 0 0 136 175 1 1
MUL1 CLPP 0 0 265 299 1 1
MUL1 NDUFA5 0 0 67 212 1 1
MUL1 TRIM72 0 0 166 179 1 1
MUL1 RNF144A 0 0 144 197 1 1
MUL1 RPL13 0 0 0 244 1 1
MUL1 MARCH6 0 0 142 169 1 1
MUL1 RASD2 0 0 160 187 1 1
MUL1 AKT1 270 0 269 457 1 2
MUL1 BCL2L1 0 0 144 165 1 2
MUL1 RNF133 0 0 195 200 1 1
MUL1 SUMO1 270 0 458 594 1 1
MUL1 CPE 0 0 0 208 1 1
MUL1 RNF121 0 0 166 172 1 1
MUL1 LONRF2 0 0 134 181 1 1
MUL1 UBE2V2 270 0 74 295 1 1
MUL1 FKBP8 0 900 276 931 1 1
MUL1 GABARAPL2 0 0 243 254 1 2
MUL1 ENSG00000279392 0 0 181 216 1 1
MUL1 MARCH8 0 0 140 199 1 1
MUL1 LETM1 0 0 74 155 1 1
MUL1 AQR 0 0 0 208 1 1
MUL1 KIAA1033 0 0 123 155 1 1
MUL1 TOPORS 0 0 240 293 1 1
MUL1 ENO1 0 0 45 253 1 1
MUL1 PML 0 0 108 226 1 2
MUL1 UBR2 0 0 95 157 1 1
MUL1 MARCH10 0 0 174 188 1 1
MUL1 PARL 0 0 456 468 1 1
MUL1 EDF1 0 0 95 212 1 1
MUL1 ABCF1 0 0 0 207 1 1
MUL1 GAPDH 0 0 163 172 1 2
MUL1 TRIM60 0 0 150 188 1 1
MUL1 ATG14 0 0 141 192 1 2
MUL1 ZNFX1 0 0 454 454 1 1
MUL1 PINK1 0 0 637 755 1 2
MUL1 EHD1 270 0 411 563 1 1
MUL1 ZNF645 0 0 160 159 1 1
MUL1 LONP1 0 0 253 315 1 1
MUL1 ESRRA 0 0 135 231 1 1
MUL1 RNF103 0 0 145 184 1 1
MUL1 UBE2D3 854 0 156 871 1 1
MUL1 SDHB 0 0 77 164 1 1
MUL1 ADRM1 0 0 95 155 1 1
MUL1 FBXO3 0 0 128 201 1 1
MUL1 FOXO4 0 0 141 194 1 1
MUL1 TRIM9 272 0 112 334 1 1
MUL1 RANBP2 0 0 193 193 1 1
MUL1 RNF187 0 0 139 176 1 1
MUL1 YME1L1 0 0 373 397 1 1
MUL1 UBE2B 0 0 75 167 1 1
MUL1 GBAS 0 0 108 201 1 1
MUL1 TRIM10 0 0 113 153 1 1
MUL1 SIAH1 0 0 314 326 1 1
MUL1 MAFK 0 0 0 188 1 1
MUL1 DENR 0 0 394 394 1 1
MUL1 ACVR1B 0 0 81 196 1 1
MUL1 PLA2G2E 0 0 108 300 1 1
MUL1 NSMCE1 0 0 124 160 1 1
MUL1 TRIM2 0 0 123 150 1 1
MUL1 IRF3 0 0 167 167 1 2
MUL1 FBXO32 0 0 390 403 1 2
MUL1 UBE2E2 192 0 74 310 1 1
MUL1 VDAC3 0 900 113 914 1 1
MUL1 FOXO3 0 0 325 344 1 2
MUL1 BBOX1 0 0 112 208 1 1
MUL1 MTOR 0 0 181 181 1 2
MUL1 ATP5D 0 0 0 271 1 1
MUL1 FAM43A 0 0 0 302 1 1
MUL1 BZW2 130 0 0 184 1 1
MUL1 USP2 0 0 96 189 1 1
MUL1 XRCC6BP1 0 0 73 152 1 1
MUL1 CISD1 0 0 165 189 1 1
MUL1 ACTG2 0 0 0 189 1 1
MUL1 CHDH 0 0 170 253 1 1
MUL1 MCU 0 0 248 248 1 2
MUL1 PEX19 275 0 171 401 1 1
MUL1 DOHH 0 0 0 153 1 1
MUL1 USP21 0 0 66 162 1 1
MUL1 PEX2 0 0 186 186 1 1
MUL1 SMURF2 0 0 95 227 1 1
MUL1 G2E3 0 0 145 180 1 1
MUL1 USP8 0 0 210 291 1 1
MUL1 CCDC53 0 0 139 192 1 1
MUL1 FAM21C 0 0 51 214 1 1
MUL1 NAA16 0 0 113 314 1 1
MUL1 FAM21A 0 0 0 206 1 1
MUL1 WDSUB1 0 0 170 181 1 1
MUL1 TRIM37 0 0 183 255 1 1
MUL1 ENDOG 0 0 210 248 1 1
MUL1 TRIM28 0 0 123 151 1 2
MUL1 OSER1 0 0 195 195 1 1
MUL1 TRIM7 0 0 113 150 1 1
MUL1 SUMO4 0 0 140 154 1 1
MUL1 PIK3C3 0 0 183 194 1 2
MUL1 SOWAHB 0 0 184 183 1 1
MUL1 UCP2 0 0 181 181 1 2
MUL1 WWP2 0 0 141 182 1 1
MUL1 UBE2R2 270 0 123 350 1 1
MUL1 TBK1 0 0 260 271 1 2
MUL1 DDOST 0 0 74 454 1 1
MUL1 RNF11 0 0 134 173 1 1
MUL1 SUMO2 0 0 230 242 1 1
MUL1 OTUD3 0 0 142 587 1 1
MUL1 PEX11A 0 0 155 154 1 1
MUL1 NEDD4 0 0 233 269 1 2
MUL1 SKP1 0 0 181 373 1 2
MUL1 UQCRC2 0 0 108 230 1 1
MUL1 RNF167 0 0 260 260 1 1
MUL1 PIAS4 0 0 217 217 1 1
MUL1 TOMM20 0 900 501 951 1 2
MUL1 STX17 0 0 261 261 1 2
MUL1 CCDC109B 0 0 101 157 1 1
MUL1 MARCH5 0 0 800 800 1 1
MUL1 RNF169 0 0 218 218 1 1
MUL1 VDAC1 0 900 390 936 1 2
MUL1 RNF24 0 0 134 173 1 1
MUL1 TRIM50 0 0 146 152 1 1
MUL1 ECI2 0 0 57 258 1 1
MUL1 ABCD3 0 0 248 248 1 1
MUL1 TMEM50B 0 0 150 498 1 1
MUL1 BNIP3L 0 0 519 549 1 2
MUL1 UBR1 0 0 181 306 1 1
MUL1 PEX13 0 0 181 181 1 1
MUL1 MAP3K6 0 0 82 169 1 1
MUL1 HRAS 0 0 45 156 1 2
MUL1 MAP1LC3A 0 0 112 185 1 2
MUL1 TRIM13 0 0 146 294 1 1
MUL1 MRPS2 0 0 0 249 1 1
MUL1 ZFYVE1 0 0 203 203 1 2
MUL1 RNF145 0 0 117 157 1 1
MUL1 APP 0 0 166 165 1 2
MUL1 MFN2 0 0 617 714 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0019789 Molecular Function SUMO transferase activity enables IDA
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0046872 Molecular Function metal ion binding enables IEA
GO:0002039 Molecular Function p53 binding enables IPI
GO:0005515 Molecular Function protein binding enables IPI
GO:0061630 Molecular Function ubiquitin protein ligase activity enables IDA
GO:0031625 Molecular Function ubiquitin protein ligase binding enables IPI
GO:0004842 Molecular Function ubiquitin-protein transferase activity enables IBA
GO:0006919 Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process involved_in IDA
GO:0006915 Biological Process apoptotic process involved_in IEA
GO:0071360 Biological Process cellular response to exogenous dsRNA involved_in IDA
GO:0000266 Biological Process mitochondrial fission involved_in IMP
GO:0051646 Biological Process mitochondrion localization involved_in IMP
GO:0030308 Biological Process negative regulation of cell growth involved_in IDA
GO:0071650 Biological Process negative regulation of chemokine (C-C motif) ligand 5 production involved_in IMP
GO:0050689 Biological Process negative regulation of defense response to virus by host involved_in IMP
GO:0045824 Biological Process negative regulation of innate immune response involved_in IMP
GO:0010637 Biological Process negative regulation of mitochondrial fusion involved_in IDA
GO:0051898 Biological Process negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in IDA
GO:0060339 Biological Process negative regulation of type I interferon-mediated signaling pathway involved_in IMP
GO:1904925 Biological Process positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization involved_in IEA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in HMP
GO:1903861 Biological Process positive regulation of dendrite extension involved_in IEA
GO:0090141 Biological Process positive regulation of mitochondrial fission involved_in IDA
GO:0033235 Biological Process positive regulation of protein sumoylation involved_in IDA
GO:0031648 Biological Process protein destabilization involved_in IMP
GO:0000209 Biological Process protein polyubiquitination involved_in IDA
GO:0050821 Biological Process protein stabilization involved_in IMP
GO:0016925 Biological Process protein sumoylation involved_in IEA
GO:0016567 Biological Process protein ubiquitination involved_in IBA
GO:0016567 Biological Process protein ubiquitination involved_in IDA
GO:0051881 Biological Process regulation of mitochondrial membrane potential involved_in IEA
GO:1901028 Biological Process regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway involved_in IDA
GO:0010821 Biological Process regulation of mitochondrion organization involved_in IMP
GO:0030424 Cellular Component axon located_in IMP
GO:0016020 Cellular Component membrane located_in HDA
GO:0005741 Cellular Component mitochondrial outer membrane located_in IDA
GO:0005741 Cellular Component mitochondrial outer membrane located_in TAS
GO:0005739 Cellular Component mitochondrion is_active_in IBA
GO:0005739 Cellular Component mitochondrion located_in IDA
GO:0005739 Cellular Component mitochondrion located_in IMP
GO:0043025 Cellular Component neuronal cell body located_in IMP
GO:0005777 Cellular Component peroxisome located_in IDA
Pathways
Name DB ID
Cellular responses to stress Reactome R-HSA-2262752
Metabolism of proteins Reactome R-HSA-392499
Deubiquitination Reactome R-HSA-5688426
Ub-specific processing proteases Reactome R-HSA-5689880
Post-translational protein modification Reactome R-HSA-597592
Neddylation Reactome R-HSA-8951664
Cellular responses to stimuli Reactome R-HSA-8953897
Cellular response to chemical stress Reactome R-HSA-9711123
KEAP1-NFE2L2 pathway Reactome R-HSA-9755511
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_024544 3 mRNA None NC_000001 Reference
XM_011542137 3 mRNA transcript variant X1 NC_000001 Reference