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NLRX1

NLR family member X1
General Information
Name NLR family member X1
Alias
  • NLR family member X1
  • NOD-like receptor X1
  • caterpiller protein 11.3
  • nucleotide-binding oligomerization domain protein 26
  • nucleotide-binding oligomerization domain protein 5
  • nucleotide-binding oligomerization domain protein 9
  • nucleotide-binding oligomerization domain, leucine rich repeat containing X1
Gene_family NLR family
organism Homo sapiens
entrez_id 79671
location 11q23.3
transcript_count 11
exon_count 11
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]
    Stringdb NLR family member X1; Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species; NLR family
    nextProt Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
NLRX1 BioGRID CLEC16A GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA
NLRX1 BioGRID RIPK2 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID ATG14 GeneID BioGRID Affinity Capture-Western
NLRX1 BioGRID BECN1 GeneID BioGRID Affinity Capture-Western
NLRX1 BioGRID UVRAG GeneID BioGRID Affinity Capture-Western
NLRX1 BioGRID PIK3C3 GeneID BioGRID Affinity Capture-Western
NLRX1 BioGRID MAVS GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
NLRX1 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID TUFM GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
NLRX1 BioGRID LDLRAD1 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID VSIG1 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID C19orf38 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID LRRC25 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID COMTD1 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID MGARP GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID ISCA1 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID PINK1 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID BRINP2 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID PCDHGB1 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID ACSM5 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID NLGN3 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID OSTM1 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID P2RY10 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID HERC4 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID GPR182 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID GPR45 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID UPK1A GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID HCST GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID CREB3 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID DGCR2 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID IL1R2 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID TGFA GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID PVR GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID PCP4 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID ADAM11 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID MBNL1 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID IL2RA GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID HCRTR2 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID GYPA GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID LPAR4 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID CCR1 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID CD79B GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID TNFSF8 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID CD3D GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID BSG GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID ACVR2B GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
NLRX1 BioGRID ORF7a GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID M GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID INS GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID HSCB GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID FAF1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
NLRX1 BioGRID CLEC2D GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID HSPA8 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID LPAR6 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID DLK1 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID GNAI2 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID MYC GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID DENR GeneID BioGRID Co-fractionation
NLRX1 BioGRID IKBKG GeneID BioGRID Affinity Capture-Western
NLRX1 BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western
NLRX1 BioGRID TRAF3 GeneID BioGRID Affinity Capture-Western
NLRX1 BioGRID IKBKB GeneID BioGRID Affinity Capture-Western
NLRX1 BioGRID SPNS1 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID FASTKD5 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID HAUS6 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID SARM1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
NLRX1 BioGRID PRDX3 GeneID BioGRID Affinity Capture-MS
NLRX1 BioGRID CDIPT GeneID BioGRID Affinity Capture-MS
StringDB
A B experiments database textmining combined score hadb nhadb
NLRX1 GNPTG 0 0 0 189 1 1
NLRX1 MAP4K4 0 0 56 161 1 1
NLRX1 IKBKG 270 0 324 555 1 1
NLRX1 C3 0 0 71 262 1 2
NLRX1 CXCR5 0 0 74 438 1 1
NLRX1 FASTKD5 157 0 704 742 1 1
NLRX1 TSG101 0 0 0 151 1 2
NLRX1 USP30 0 0 83 257 1 1
NLRX1 PHLDB1 0 0 180 197 1 1
NLRX1 MAP1LC3B 0 0 161 179 1 2
NLRX1 ISG15 0 0 266 266 1 2
NLRX1 EIF2A 0 0 0 244 1 2
NLRX1 SLC15A3 0 0 108 159 1 1
NLRX1 SUGT1 0 0 160 172 1 1
NLRX1 NLRP14 0 0 369 209 1 1
NLRX1 ATG5 0 0 858 858 1 2
NLRX1 CALCOCO2 0 0 142 161 1 2
NLRX1 NIPSNAP1 0 0 107 162 1 1
NLRX1 TLR8 0 0 310 311 1 1
NLRX1 IRF1 0 0 264 281 1 2
NLRX1 CTSB 0 0 195 204 1 2
NLRX1 SIKE1 0 0 460 461 1 1
NLRX1 EYA4 0 0 603 613 1 1
NLRX1 IRF5 0 0 143 196 1 1
NLRX1 HMGB1 0 0 150 187 1 2
NLRX1 IFNB1 0 0 517 517 1 1
NLRX1 JTB 0 0 173 398 1 1
NLRX1 AMBRA1 0 0 117 196 1 2
NLRX1 KLHL22 0 0 123 156 1 1
NLRX1 ZC3H12A 0 0 162 210 1 1
NLRX1 NFKBIA 0 0 234 289 1 2
NLRX1 RHOT2 0 0 0 335 1 1
NLRX1 ABCB7 0 0 0 171 1 1
NLRX1 TRAFD1 0 0 112 174 1 1
NLRX1 NLRP6 0 0 636 300 1 1
NLRX1 IRF4 0 0 113 159 1 1
NLRX1 DAK 0 0 257 316 1 1
NLRX1 FCER1G 0 0 66 226 1 1
NLRX1 TRAF7 0 0 90 151 1 1
NLRX1 PDZD3 0 0 105 435 1 1
NLRX1 CASP5 0 0 282 306 1 1
NLRX1 PLN 0 0 71 169 1 1
NLRX1 KIAA0226 0 0 155 239 1 1
NLRX1 ZHX3 0 0 103 208 1 1
NLRX1 ATG7 0 0 163 169 1 2
NLRX1 TRAT1 0 0 161 179 1 1
NLRX1 OTUD5 0 0 405 430 1 1
NLRX1 IL10 0 0 181 181 1 2
NLRX1 VWA1 0 0 0 156 1 1
NLRX1 IRAK4 0 0 154 153 1 1
NLRX1 TIPRL 0 0 165 172 1 1
NLRX1 RNF26 0 0 218 434 1 1
NLRX1 TRIM32 0 0 140 374 1 1
NLRX1 TOMM70A 0 0 310 320 1 1
NLRX1 TSPAN6 0 0 181 181 1 1
NLRX1 COL17A1 0 0 58 162 1 1
NLRX1 CCDC84 0 0 205 205 1 1
NLRX1 SAMHD1 0 0 181 181 1 1
NLRX1 FBXO17 0 0 97 159 1 1
NLRX1 NLRP11 0 0 465 236 1 1
NLRX1 CHUK 0 0 543 610 1 1
NLRX1 MOK 0 0 96 207 1 1
NLRX1 OR9G1 0 0 181 181 1 1
NLRX1 ARRDC3 0 0 66 159 1 1
NLRX1 PHB2 0 0 108 187 1 1
NLRX1 LAMTOR1 0 0 0 179 1 1
NLRX1 RIPK1 0 0 182 264 1 2
NLRX1 NOD2 0 0 668 381 1 2
NLRX1 CIITA 0 0 600 691 1 1
NLRX1 ECSIT 0 0 323 349 1 1
NLRX1 ATG16L1 0 0 635 635 1 2
NLRX1 SMURF1 0 0 170 188 1 1
NLRX1 AICDA 0 0 0 195 1 1
NLRX1 PTGS2 0 0 95 157 1 2
NLRX1 IL33 0 0 207 207 1 2
NLRX1 PSMB6 0 0 0 199 1 1
NLRX1 NUF2 0 0 0 165 1 1
NLRX1 NLRP3 0 0 614 308 1 2
NLRX1 TRIM56 0 0 203 348 1 1
NLRX1 LIME1 0 0 124 150 1 1
NLRX1 NIP7 0 0 142 154 1 1
NLRX1 PPM1B 0 0 0 269 1 1
NLRX1 ATG12 0 0 598 598 1 2
NLRX1 MAPK11 0 0 70 173 1 1
NLRX1 TLR2 0 0 325 339 1 2
NLRX1 TOLLIP 0 0 146 208 1 1
NLRX1 TRAF3 270 0 666 758 1 2
NLRX1 PPM1A 0 0 150 514 1 1
NLRX1 BECN1 0 0 705 709 1 2
NLRX1 TLR6 0 0 161 162 1 1
NLRX1 SHARPIN 0 0 108 291 1 1
NLRX1 NOD1 0 0 682 410 1 2
NLRX1 CHD9 0 0 73 164 1 1
NLRX1 USP20 0 0 122 200 1 1
NLRX1 TBKBP1 0 0 170 216 1 1
NLRX1 MLEC 0 0 94 299 1 1
NLRX1 IRAK3 0 0 268 284 1 1
NLRX1 FAF1 270 0 246 426 1 1
NLRX1 NUP155 0 0 66 172 1 1
NLRX1 PNPLA7 0 0 45 189 1 1
NLRX1 SNRNP200 0 0 0 221 1 1
NLRX1 UEVLD 0 0 0 156 1 1
NLRX1 RNF122 0 0 150 173 1 1
NLRX1 HAX1 0 0 73 166 1 1
NLRX1 TLR9 0 0 335 336 1 2
NLRX1 CARD6 0 0 103 162 1 1
NLRX1 GBAS 0 0 96 168 1 1
NLRX1 PYCARD 0 0 451 452 1 2
NLRX1 NLRP7 0 0 560 283 1 1
NLRX1 DENR 271 0 84 307 1 1
NLRX1 PRDX3 157 0 0 173 1 1
NLRX1 UBXN10 0 0 162 327 1 1
NLRX1 IRF3 0 0 680 682 1 2
NLRX1 USP3 0 0 152 170 1 1
NLRX1 SIRT4 270 0 45 288 1 1
NLRX1 CYLD 0 0 332 346 1 1
NLRX1 CXCL10 0 0 445 445 1 2
NLRX1 USP25 0 0 154 285 1 1
NLRX1 EYA2 0 0 276 276 1 1
NLRX1 PDLIM2 0 0 141 180 1 1
NLRX1 NLRC4 0 0 632 641 1 2
NLRX1 IKBKB 270 0 323 518 1 2
NLRX1 PANX1 0 0 280 280 1 1
NLRX1 DEFB135 0 0 0 188 1 1
NLRX1 RPLP2 0 0 0 204 1 1
NLRX1 LY96 0 0 122 176 1 1
NLRX1 AKT1 0 0 134 165 1 2
NLRX1 CD4 0 0 194 214 1 2
NLRX1 ARHGAP20 0 0 0 213 1 1
NLRX1 IFIT3 0 0 183 205 1 1
NLRX1 CARD8 0 0 282 328 1 1
NLRX1 PCYOX1L 0 0 0 183 1 1
NLRX1 CUEDC2 0 0 136 154 1 1
NLRX1 VDAC1 0 0 218 224 1 2
NLRX1 BNIP3L 0 0 91 153 1 2
NLRX1 FKBP6 0 0 102 196 1 1
NLRX1 PRKCD 0 0 47 179 1 2
NLRX1 DEFB127 0 0 0 297 1 1
NLRX1 IFIT1 0 0 262 262 1 1
NLRX1 CLEC5A 0 0 203 203 1 1
NLRX1 TBK1 0 0 544 553 1 2
NLRX1 NDFIP1 0 0 123 168 1 1
NLRX1 FASTKD3 0 0 136 226 1 1
NLRX1 GEMIN6 0 0 207 207 1 1
NLRX1 SLFN11 0 0 203 232 1 1
NLRX1 TRIM14 0 0 134 166 1 1
NLRX1 NWD1 0 0 213 696 1 1
NLRX1 MARCH5 0 0 231 269 1 1
NLRX1 RSAD2 0 0 193 208 1 1
NLRX1 TLR3 0 0 413 414 1 2
NLRX1 MCU 0 0 0 183 1 2
NLRX1 C1QBP 0 0 401 400 1 1
NLRX1 SP2 0 0 0 261 1 1
NLRX1 CCNO 0 0 90 433 1 1
NLRX1 RASGEF1B 0 0 0 205 1 1
NLRX1 PSIP1 0 0 119 254 1 1
NLRX1 IRAK2 0 0 163 207 1 1
NLRX1 PPIP5K2 0 0 0 198 1 1
NLRX1 C14orf2 0 0 0 273 1 1
NLRX1 C14orf169 0 0 82 210 1 1
NLRX1 NLRP2 0 0 418 225 1 1
NLRX1 LRRC25 0 0 139 172 1 1
NLRX1 RPS6KB1 0 0 61 276 1 2
NLRX1 DDX60 0 0 140 179 1 1
NLRX1 CDIPT 391 0 0 552 1 1
NLRX1 PDPK1 0 0 0 268 1 2
NLRX1 PSMA7 0 0 391 396 1 1
NLRX1 TP53I3 0 0 85 167 1 1
NLRX1 CHIT1 0 0 67 165 1 1
NLRX1 RNASEL 0 0 234 234 1 1
NLRX1 PNPLA6 0 0 0 206 1 1
NLRX1 NAIP 0 0 519 533 1 1
NLRX1 ITCH 0 0 324 323 1 1
NLRX1 DDX3X 0 0 210 216 1 1
NLRX1 RNF135 0 900 332 931 1 1
NLRX1 TIRAP 0 0 261 261 1 1
NLRX1 TANK 0 0 342 342 1 2
NLRX1 EYA3 0 0 352 366 1 1
NLRX1 TNF 0 0 325 327 1 2
NLRX1 NBR1 0 0 100 161 1 2
NLRX1 GNAI2 130 0 0 151 1 1
NLRX1 C6 0 0 94 198 1 1
NLRX1 CD6 0 0 95 251 1 1
NLRX1 IFI35 0 0 90 214 1 1
NLRX1 RNF41 0 0 134 155 1 1
NLRX1 SOCS1 0 0 181 200 1 1
NLRX1 IRF7 0 0 392 417 1 1
NLRX1 AGK 0 0 48 286 1 1
NLRX1 UVRAG 0 0 445 445 1 2
NLRX1 ATG4B 0 0 103 169 1 2
NLRX1 NFKB2 0 0 165 202 1 1
NLRX1 LAMTOR3 0 0 0 183 1 1
NLRX1 IFNAR1 0 0 210 210 1 1
NLRX1 IFI16 0 0 323 323 1 1
NLRX1 TNFSF14 0 0 141 201 1 1
NLRX1 LAMTOR2 0 0 0 171 1 1
NLRX1 TXNIP 0 0 235 247 1 2
NLRX1 CD79B 130 0 0 150 1 1
NLRX1 RPS6KB2 0 0 0 177 1 2
NLRX1 P2RX7 0 0 233 263 1 2
NLRX1 CISH 0 0 113 243 1 1
NLRX1 MX2 0 0 210 231 1 1
NLRX1 TUFM 270 0 982 987 1 2
NLRX1 IFIH1 0 900 595 959 1 1
NLRX1 DDX1 0 0 124 212 1 1
NLRX1 ZDHHC1 0 0 170 487 1 1
NLRX1 ACSF3 0 0 0 157 1 1
NLRX1 RPLP1 0 0 0 153 1 1
NLRX1 PCBP2 0 0 673 673 1 1
NLRX1 TRIM5 0 0 205 214 1 1
NLRX1 RAB8B 0 0 122 156 1 2
NLRX1 RNF19A 0 0 148 342 1 1
NLRX1 NLRP5 0 0 467 246 1 1
NLRX1 TRAF6 270 0 987 991 1 2
NLRX1 NWD2 0 0 140 591 1 1
NLRX1 DHX36 0 0 118 229 1 1
NLRX1 TLR7 0 0 368 383 1 2
NLRX1 CYCS 0 0 150 182 1 2
NLRX1 ROBO3 0 0 309 309 1 1
NLRX1 IFNA6 0 0 630 630 1 1
NLRX1 BIRC3 0 0 107 172 1 1
NLRX1 MYLK 0 0 0 209 1 1
NLRX1 CARD17 0 0 0 152 1 1
NLRX1 CCL2 0 0 180 201 1 2
NLRX1 LRRFIP1 0 0 117 186 1 1
NLRX1 CASP8 0 0 453 461 1 2
NLRX1 MAVS 486 800 989 998 1 2
NLRX1 TRADD 0 0 187 286 1 1
NLRX1 BSG 239 0 0 238 1 1
NLRX1 TRIM21 0 0 183 261 1 1
NLRX1 C8B 0 0 91 398 1 1
NLRX1 BCL2L13 0 0 108 300 1 2
NLRX1 EMC6 0 0 142 183 1 1
NLRX1 TMEM201 0 0 0 159 1 1
NLRX1 MB21D1 0 0 392 392 1 1
NLRX1 SPCS1 0 0 0 169 1 1
NLRX1 UBXN1 0 0 325 325 1 1
NLRX1 DDX58 0 900 700 969 1 1
NLRX1 AIM2 0 0 469 469 1 2
NLRX1 DDX41 0 0 322 336 1 1
NLRX1 FKBP4 0 0 86 158 1 1
NLRX1 MIP 0 0 167 167 1 1
NLRX1 HLA-DOA 0 0 113 171 1 1
NLRX1 N4BP1 0 0 67 174 1 1
NLRX1 TLR5 0 0 269 316 1 1
NLRX1 HSPA8 131 0 96 192 1 2
NLRX1 NMRAL1 0 0 160 159 1 1
NLRX1 ATG9A 0 0 180 432 1 2
NLRX1 RALB 0 0 0 187 1 2
NLRX1 ABCG4 0 0 134 168 1 1
NLRX1 DEFB124 0 0 179 346 1 1
NLRX1 UNC93B1 0 0 146 226 1 1
NLRX1 RRNAD1 0 0 243 242 1 1
NLRX1 NLRP9 0 0 467 248 1 1
NLRX1 MLKL 0 0 66 209 1 2
NLRX1 MUL1 0 0 203 251 1 2
NLRX1 COX4I1 0 0 125 198 1 1
NLRX1 C4BPA 0 0 94 160 1 1
NLRX1 HSP90AA1 0 0 124 156 1 2
NLRX1 SBF1 0 0 0 162 1 1
NLRX1 RNF5 0 0 402 426 1 1
NLRX1 SQSTM1 0 0 134 153 1 2
NLRX1 HAUS6 157 0 0 157 1 1
NLRX1 CD40 0 0 112 212 1 2
NLRX1 ACTB 0 0 181 198 1 2
NLRX1 ZCCHC11 0 0 0 354 1 1
NLRX1 SERINC3 0 0 136 154 1 1
NLRX1 TRIM38 0 0 342 381 1 1
NLRX1 ARSI 0 0 45 201 1 1
NLRX1 CASP1 0 0 543 566 1 2
NLRX1 RHOT1 0 0 0 226 1 1
NLRX1 DHX15 0 0 103 253 1 1
NLRX1 TMEM173 0 0 609 620 1 1
NLRX1 TRIM11 0 0 150 183 1 1
NLRX1 VPS37C 0 0 0 170 1 1
NLRX1 TRIM17 0 0 134 166 1 1
NLRX1 ENSG00000173366 0 0 339 340 1 1
NLRX1 AMFR 0 0 142 492 1 1
NLRX1 NLRP13 0 0 344 175 1 1
NLRX1 USP4 0 0 150 181 1 1
NLRX1 DTX4 0 0 321 325 1 1
NLRX1 NLRP8 0 0 261 193 1 1
NLRX1 TICAM1 0 0 486 516 1 2
NLRX1 CLEC6A 0 0 134 157 1 1
NLRX1 ZCCHC6 0 0 0 261 1 1
NLRX1 RIPK2 0 0 391 401 1 2
NLRX1 CREB3 273 0 0 273 1 1
NLRX1 EIF2AK2 0 0 48 274 1 2
NLRX1 MFN1 0 0 321 364 1 2
NLRX1 MYBPH 0 0 57 155 1 1
NLRX1 FUNDC1 0 0 124 258 1 2
NLRX1 CD8A 0 0 213 213 1 1
NLRX1 IQGAP1 0 0 290 302 1 1
NLRX1 PLK1 0 0 142 179 1 2
NLRX1 SLC25A6 0 0 160 159 1 1
NLRX1 LAMTOR5 0 0 337 337 1 1
NLRX1 BIRC2 0 0 135 198 1 1
NLRX1 DHX9 0 0 112 211 1 1
NLRX1 CCL5 0 0 307 307 1 2
NLRX1 GSDMD 0 0 150 192 1 2
NLRX1 ACO2 0 0 248 285 1 1
NLRX1 KCNJ11 0 0 321 321 1 1
NLRX1 LONP1 0 0 139 213 1 1
NLRX1 FKBP8 0 0 70 219 1 1
NLRX1 TLR4 0 0 369 370 1 2
NLRX1 APTX 0 0 0 228 1 1
NLRX1 TMEM102 0 0 166 233 1 1
NLRX1 GAPDH 0 0 162 172 1 2
NLRX1 NFKB1 0 0 170 225 1 2
NLRX1 BCL2L1 0 0 134 175 1 2
NLRX1 RELA 0 0 140 183 1 2
NLRX1 COX5B 0 0 305 345 1 1
NLRX1 TRIM25 0 900 456 945 1 1
NLRX1 CLEC7A 0 0 210 210 1 1
NLRX1 TLR10 0 0 134 173 1 1
NLRX1 TAB3 0 0 139 178 1 1
NLRX1 TRIM4 0 0 205 214 1 1
NLRX1 LDHD 0 0 0 212 1 1
NLRX1 UQCRB 0 0 66 162 1 1
NLRX1 MVB12B 0 0 0 155 1 1
NLRX1 IKBKE 0 0 155 305 1 1
NLRX1 IFNA4 0 0 573 573 1 1
NLRX1 MFN2 0 0 372 441 1 2
NLRX1 CXCL8 0 0 171 171 1 2
NLRX1 MAPK13 0 0 90 151 1 1
NLRX1 UQCRC2 0 0 988 988 1 1
NLRX1 TRAF5 0 0 246 264 1 1
NLRX1 TRIM27 0 0 92 156 1 1
NLRX1 IL1B 0 0 418 418 1 2
NLRX1 STAT1 0 0 242 251 1 2
NLRX1 RNASE1 0 0 43 158 1 1
NLRX1 SBK1 0 0 0 303 1 1
NLRX1 DEFB125 0 0 235 393 1 1
NLRX1 TNFRSF1A 0 0 180 197 1 1
NLRX1 IL17D 0 0 95 233 1 1
NLRX1 PIK3C3 0 0 150 171 1 2
NLRX1 NLRC3 0 0 800 412 1 1
NLRX1 TRIM7 0 0 104 168 1 1
NLRX1 IL6 0 0 325 325 1 2
NLRX1 APOBEC3G 0 0 113 161 1 1
NLRX1 NLRP1 0 0 611 292 1 1
NLRX1 HEATR4 0 0 209 209 1 1
NLRX1 DDX21 0 0 113 278 1 1
NLRX1 TRAF4 0 0 166 186 1 1
NLRX1 SPNS1 157 0 101 209 1 2
NLRX1 DEFB128 0 0 0 193 1 1
NLRX1 NLRP4 0 0 607 294 1 1
NLRX1 MAP3K7 0 0 118 165 1 2
NLRX1 ZBP1 0 0 154 154 1 1
NLRX1 P2RX4 0 0 74 156 1 1
NLRX1 IRAK1 0 0 323 347 1 1
NLRX1 CARD9 0 0 235 277 1 1
NLRX1 TRAF1 0 0 126 202 1 1
NLRX1 FADD 0 0 206 228 1 2
NLRX1 SARM1 397 0 837 897 1 1
NLRX1 MYD88 0 0 374 390 1 2
NLRX1 BNIP2 0 0 194 194 1 1
NLRX1 CD300C 0 0 134 206 1 1
NLRX1 MVB12A 0 0 0 155 1 1
NLRX1 BAZ2A 0 0 235 251 1 1
NLRX1 CISD2 0 0 0 171 1 2
NLRX1 NLRC5 0 0 739 446 1 1
NLRX1 APAF1 0 0 180 417 1 2
NLRX1 HSCB 270 0 0 270 1 1
NLRX1 MEFV 0 0 559 564 1 1
NLRX1 MX1 0 0 161 182 1 1
NLRX1 TAB1 0 0 184 251 1 1
NLRX1 SLC15A4 0 0 103 159 1 1
NLRX1 DHX33 0 0 113 272 1 1
NLRX1 TAB2 0 0 246 245 1 2
NLRX1 IL1R1 0 0 184 183 1 1
NLRX1 RNF125 0 0 469 481 1 1
NLRX1 IRGM 0 0 210 210 1 2
NLRX1 TAX1BP3 0 0 193 198 1 1
NLRX1 IL18 0 0 465 465 1 2
NLRX1 PPIP5K1 0 0 0 198 1 1
NLRX1 IFNA1 0 0 283 282 1 1
NLRX1 CD80 0 0 90 199 1 2
NLRX1 NLRP12 0 0 654 315 1 1
NLRX1 CYB5D1 0 0 181 181 1 1
NLRX1 RBCK1 0 0 49 306 1 1
NLRX1 AQP1 0 0 213 213 1 1
NLRX1 DHX58 0 0 508 545 1 1
NLRX1 PGAM5 0 0 103 199 1 1
NLRX1 TLR1 0 0 285 286 1 1
NLRX1 NLRP10 0 0 519 249 1 1
NLRX1 SPEG 0 0 0 315 1 1
NLRX1 C2CD4A 0 0 96 158 1 1
NLRX1 TAX1BP1 0 0 240 251 1 2
NLRX1 ACTA1 0 0 74 150 1 1
NLRX1 COX7A2 0 0 0 154 1 1
NLRX1 TTN 0 0 0 231 1 1
NLRX1 FASTK 0 0 108 240 1 1
NLRX1 ARCN1 0 0 167 182 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005524 Molecular Function ATP binding enables IEA
GO:0005515 Molecular Function protein binding enables IPI
GO:0045087 Biological Process innate immune response involved_in IEA
GO:0039536 Biological Process negative regulation of RIG-I signaling pathway involved_in IEA
GO:0043124 Biological Process negative regulation of canonical NF-kappaB signal transduction involved_in IBA
GO:0050728 Biological Process negative regulation of inflammatory response involved_in IEA
GO:0045824 Biological Process negative regulation of innate immune response involved_in IEA
GO:0032688 Biological Process negative regulation of interferon-beta production involved_in IEA
GO:0032715 Biological Process negative regulation of interleukin-6 production involved_in IEA
GO:0010936 Biological Process negative regulation of macrophage cytokine production involved_in IEA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005741 Cellular Component mitochondrial outer membrane located_in TAS
GO:0005739 Cellular Component mitochondrion is_active_in IBA
GO:0005739 Cellular Component mitochondrion located_in IDA
GO:0005886 Cellular Component plasma membrane located_in IDA
Pathways
Name DB ID
Cytokine Signaling in Immune system Reactome R-HSA-1280215
Toll Like Receptor 4 (TLR4) Cascade Reactome R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane Reactome R-HSA-166058
MyD88-independent TLR4 cascade Reactome R-HSA-166166
Toll Like Receptor 9 (TLR9) Cascade Reactome R-HSA-168138
Toll Like Receptor 10 (TLR10) Cascade Reactome R-HSA-168142
Toll Like Receptor 3 (TLR3) Cascade Reactome R-HSA-168164
Toll Like Receptor 5 (TLR5) Cascade Reactome R-HSA-168176
Toll Like Receptor TLR1:TLR2 Cascade Reactome R-HSA-168179
Toll Like Receptor 7/8 (TLR7/8) Cascade Reactome R-HSA-168181
Toll Like Receptor TLR6:TLR2 Cascade Reactome R-HSA-168188
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Toll-like Receptor Cascades Reactome R-HSA-168898
DDX58/IFIH1-mediated induction of interferon-alpha/beta Reactome R-HSA-168928
Toll Like Receptor 2 (TLR2) Cascade Reactome R-HSA-181438
TAK1-dependent IKK and NF-kappa-B activation Reactome R-HSA-445989
Interleukin-1 family signaling Reactome R-HSA-446652
Signaling by Interleukins Reactome R-HSA-449147
Interleukin-1 signaling Reactome R-HSA-9020702
Negative regulators of DDX58/IFIH1 signaling Reactome R-HSA-936440
TRIF(TICAM1)-mediated TLR4 signaling Reactome R-HSA-937061
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Reactome R-HSA-975138
MyD88 dependent cascade initiated on endosome Reactome R-HSA-975155
Regulation of NF-kappa B signaling Reactome R-HSA-9758274
MyD88 cascade initiated on plasma membrane Reactome R-HSA-975871
STING pathway in Kawasaki-like disease and COVID-19 (WP4961) WikiPathways WP4961_r123345
Mitochondrial immune response to SARS-CoV-2 (WP5038) WikiPathways WP5038_r124641
SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction (WP5183) WikiPathways WP5183_r124655
Cytosolic DNA-sensing pathway (WP4655) WikiPathways WP4655_r123496
Novel intracellular components of RIG-I-like receptor pathway (WP3865) WikiPathways WP3865_r123636
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001282358 2 mRNA transcript variant 5 NC_000011 Reference
XM_011542980 2 mRNA transcript variant X2 NC_000011 Reference
NM_001282144 2 mRNA transcript variant 4 NC_000011 Reference
XM_006718904 2 mRNA transcript variant X4 NC_000011 Reference
XM_005271669 2 mRNA transcript variant X1 NC_000011 Reference
XM_047427586 1 mRNA transcript variant X3 NC_000011 Reference
NM_024618 4 mRNA transcript variant 1 NC_000011 Reference
NM_170722 2 mRNA transcript variant 2 NC_000011 Reference
NM_001282143 2 mRNA transcript variant 3 NC_000011 Reference
XM_047427587 1 mRNA transcript variant X5 NC_000011 Reference
XM_047427589 1 mRNA transcript variant X6 NC_000011 Reference