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GSDMD

gasdermin D
General Information
Name gasdermin D
Alias
  • gasdermin-D
  • gasdermin domain containing 1
  • gasdermin domain-containing protein 1
Gene_family Gasdermins
organism Homo sapiens
entrez_id 79792
location 8q24.3
transcript_count 2
exon_count 14
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
    Stringdb Gasdermin-D; Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)- bisphosphate, as well as phosphati [...]
    nextProt Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27281216). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:27281216).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
GSDMD BioGRID ORF1ab GeneID BioGRID Biochemical Activity
GSDMD BioGRID ORF1ab GeneID BioGRID Biochemical Activity
GSDMD BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
GSDMD BioGRID EPHA1 GeneID BioGRID Proximity Label-MS
GSDMD BioGRID INTS12 GeneID BioGRID Co-fractionation
GSDMD BioGRID SYVN1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
GSDMD BioGRID IRAK3 GeneID BioGRID Affinity Capture-Western
GSDMD BioGRID CDC37 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
GSDMD BioGRID ATG7 GeneID BioGRID Affinity Capture-Western
GSDMD BioGRID NEDD4 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
GSDMD BioGRID IL1B GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
GSDMD BioGRID HSP90AB1 GeneID BioGRID Affinity Capture-MS
GSDMD BioGRID HSP90AA1 GeneID BioGRID Affinity Capture-Western
GSDMD BioGRID CASP8 GeneID BioGRID Affinity Capture-Western
GSDMD BioGRID ASPG GeneID BioGRID Two-hybrid
GSDMD BioGRID KCTD6 GeneID BioGRID Two-hybrid
GSDMD BioGRID ZNF558 GeneID BioGRID Two-hybrid
GSDMD BioGRID ZNF426 GeneID BioGRID Two-hybrid
GSDMD BioGRID ZBTB33 GeneID BioGRID Two-hybrid
GSDMD BioGRID PSMA1 GeneID BioGRID Two-hybrid
GSDMD BioGRID MEOX2 GeneID BioGRID Two-hybrid
GSDMD BioGRID MFHAS1 GeneID BioGRID Reconstituted Complex
StringDB
A B experiments database textmining combined score hadb nhadb
GSDMD KRTAP10-8 0 0 171 239 1 1
GSDMD BIRC2 0 0 181 220 1 1
GSDMD TMEM86B 0 0 211 269 1 1
GSDMD CCL5 0 0 112 173 1 2
GSDMD KRTAP20-4 0 0 174 173 1 1
GSDMD KRTAP5-7 0 0 155 154 1 1
GSDMD CXCL10 0 0 134 175 1 2
GSDMD KCNJ11 0 0 113 150 1 1
GSDMD MALT1 0 0 188 188 1 1
GSDMD ZC3H3 0 0 123 212 1 1
GSDMD KRTAP11-1 0 0 123 187 1 1
GSDMD CYLD 0 0 150 208 1 1
GSDMD PPFIA1 0 0 189 276 1 1
GSDMD PIKFYVE 0 0 81 319 1 2
GSDMD PANX3 0 0 103 220 1 1
GSDMD KRTAP13-4 0 0 167 250 1 1
GSDMD TLR9 0 0 252 268 1 2
GSDMD GSDMA 0 0 856 224 1 1
GSDMD PYCARD 0 720 662 915 1 2
GSDMD ZNF558 242 0 0 241 1 1
GSDMD NLRP7 0 0 456 512 1 1
GSDMD ANXA5 0 0 293 313 1 2
GSDMD IRF3 0 0 314 354 1 2
GSDMD PRR12 0 0 142 210 1 1
GSDMD UBA7 0 0 0 266 1 1
GSDMD KRTAP4-1 0 0 159 206 1 1
GSDMD LY96 0 0 212 240 1 1
GSDMD GBP2 0 0 324 363 1 1
GSDMD CD4 0 0 164 188 1 2
GSDMD ARHGAP4 0 0 0 155 1 1
GSDMD CASP6 0 0 217 283 1 1
GSDMD CARD8 0 720 294 807 1 1
GSDMD CLEC7A 0 0 181 198 1 1
GSDMD ITPR2 0 0 0 212 1 1
GSDMD PANX1 0 0 506 519 1 1
GSDMD CENPV 0 0 473 473 1 1
GSDMD NLRC4 0 720 789 949 1 2
GSDMD KRTAP9-4 0 0 157 194 1 1
GSDMD KRTAP21-2 0 0 157 156 1 1
GSDMD KRTAP19-7 0 0 156 155 1 1
GSDMD XIAP 0 0 181 188 1 2
GSDMD KRTAP15-1 0 0 134 197 1 1
GSDMD TLR4 0 0 470 481 1 2
GSDMD GAPDH 0 0 336 348 1 2
GSDMD CXCL8 0 0 166 165 1 2
GSDMD TBK1 0 0 200 219 1 2
GSDMD KRTAP5-10 0 0 164 182 1 1
GSDMD UPK1A 0 0 66 170 1 1
GSDMD UPK1B 0 0 61 158 1 1
GSDMD KRTAP19-3 0 0 160 159 1 1
GSDMD IL1B 0 0 710 729 1 2
GSDMD RAC2 0 0 0 150 1 1
GSDMD VDAC1 0 0 134 152 1 2
GSDMD CALD1 0 0 0 155 1 1
GSDMD DPP8 0 0 403 495 1 1
GSDMD KRTAP8-1 0 0 113 208 1 1
GSDMD RIPK3 0 0 612 643 1 2
GSDMD NAPRT 0 0 74 168 1 1
GSDMD PARP10 0 0 0 179 1 1
GSDMD UPK2 0 0 60 167 1 1
GSDMD TRPV2 0 0 103 171 1 1
GSDMD NLRP1 0 720 681 912 1 1
GSDMD KRTAP10-1 0 0 150 184 1 1
GSDMD KRTAP22-1 0 0 158 157 1 1
GSDMD KRT85 0 0 95 235 1 1
GSDMD DDX19A 0 0 160 159 1 1
GSDMD KRTAP16-1 0 0 159 177 1 1
GSDMD IRF8 0 0 123 228 1 1
GSDMD KRT73 0 0 123 259 1 1
GSDMD KRTAP12-3 0 0 157 175 1 1
GSDMD KRTAP4-9 0 0 137 174 1 1
GSDMD STAT1 0 0 171 190 1 2
GSDMD KRT12 0 0 60 154 1 1
GSDMD TNFRSF1A 0 0 261 295 1 1
GSDMD TLR3 0 0 267 283 1 2
GSDMD PIK3C3 0 0 63 246 1 2
GSDMD MPO 0 0 203 203 1 2
GSDMD NLRC3 0 0 150 218 1 1
GSDMD HRNR 0 0 70 184 1 1
GSDMD IL6 0 0 358 372 1 2
GSDMD C14orf177 0 0 218 218 1 1
GSDMD SCAF11 0 0 404 404 1 1
GSDMD RASA3 0 0 245 524 1 1
GSDMD KRTAP22-2 0 0 174 173 1 1
GSDMD LAMP1 0 0 134 176 1 2
GSDMD LRRC25 0 0 97 165 1 1
GSDMD FADD 0 0 350 349 1 2
GSDMD NLRP2 0 0 325 395 1 1
GSDMD CHMP4B 0 0 107 159 1 2
GSDMD UPK3A 0 0 55 174 1 1
GSDMD KRT39 0 0 134 268 1 1
GSDMD MYD88 0 0 341 374 1 2
GSDMD PSTPIP1 0 0 125 169 1 1
GSDMD MAP3K13 0 0 265 265 1 1
GSDMD CFLAR 0 0 253 326 1 2
GSDMD KRTAP4-6 0 0 154 190 1 1
GSDMD KRTAP5-11 0 0 167 167 1 1
GSDMD NLRP4 0 0 137 371 1 1
GSDMD LHFPL1 0 0 213 351 1 1
GSDMD ZBP1 0 0 294 328 1 1
GSDMD MAP1A 0 0 63 207 1 2
GSDMD IRAK1 0 0 180 190 1 1
GSDMD CAMP 0 0 194 194 1 2
GSDMD CARD9 0 0 211 333 1 1
GSDMD KRTAP13-1 0 0 112 173 1 1
GSDMD CARD18 0 0 161 215 1 1
GSDMD DFFA 0 0 147 211 1 1
GSDMD OXSR1 0 0 0 175 1 1
GSDMD LPCAT3 0 0 108 169 1 1
GSDMD NLRC5 0 0 212 273 1 1
GSDMD BAK1 0 0 139 170 1 2
GSDMD APAF1 0 0 232 231 1 2
GSDMD KRTAP19-6 0 0 163 163 1 1
GSDMD HMHA1 0 0 90 191 1 1
GSDMD TXN 0 0 181 181 1 1
GSDMD S100A10 0 0 0 206 1 1
GSDMD NUBP2 0 0 346 373 1 1
GSDMD HINT2 0 0 142 201 1 1
GSDMD KRTAP3-2 0 0 141 183 1 1
GSDMD RAB8A 0 0 125 276 1 2
GSDMD GPSM3 0 0 0 161 1 1
GSDMD PRB1 0 0 303 303 1 1
GSDMD TIRAP 0 0 135 227 1 1
GSDMD IL36G 0 0 0 197 1 1
GSDMD KRTAP12-1 0 0 165 204 1 1
GSDMD TNF 0 0 380 419 1 2
GSDMD KRT37 0 0 60 206 1 1
GSDMD ATP11C 0 0 118 152 1 1
GSDMD IL1RN 0 0 113 296 1 1
GSDMD CASP2 0 0 285 337 1 1
GSDMD IL1R1 0 0 371 384 1 1
GSDMD IL18 0 0 776 807 1 2
GSDMD IFNA1 0 0 155 154 1 1
GSDMD KRTAP25-1 0 0 171 171 1 1
GSDMD KRTAP12-4 0 0 174 192 1 1
GSDMD NAIP 0 540 519 780 1 1
GSDMD DDX3X 0 720 49 722 1 1
GSDMD MEFV 0 0 710 744 1 1
GSDMD SIPA1 0 0 0 157 1 1
GSDMD DFNB59 0 0 604 284 1 1
GSDMD KRTAP10-5 0 0 167 185 1 1
GSDMD DHX33 0 720 322 802 1 1
GSDMD RBFOX3 0 0 147 165 1 1
GSDMD KRTAP9-1 0 0 152 189 1 1
GSDMD KRTAP21-3 0 0 171 171 1 1
GSDMD CASP10 0 0 155 274 1 1
GSDMD KRTCAP2 0 0 106 245 1 1
GSDMD IFNAR1 0 0 265 265 1 1
GSDMD FLII 0 0 112 185 1 1
GSDMD KRTAP9-3 0 0 156 193 1 1
GSDMD TXNIP 0 0 379 392 1 2
GSDMD IFI16 0 0 391 430 1 1
GSDMD KRTAP19-8 0 0 172 171 1 1
GSDMD KRT81 0 0 74 173 1 1
GSDMD KRTAP4-12 0 0 161 197 1 1
GSDMD RBCK1 0 0 137 202 1 1
GSDMD GBP5 0 0 281 300 1 1
GSDMD NLRP12 0 0 358 358 1 1
GSDMD KRT38 0 0 123 259 1 1
GSDMD KRTAP4-4 0 0 156 174 1 1
GSDMD IFI35 0 0 0 171 1 1
GSDMD DHX58 0 0 107 178 1 1
GSDMD MARCH7 0 0 248 248 1 1
GSDMD CALCOCO1 0 0 98 154 1 1
GSDMD RAB39A 0 0 194 528 1 1
GSDMD TREX1 0 0 0 201 1 1
GSDMD TLR1 0 0 135 171 1 1
GSDMD PGAM5 0 0 181 196 1 1
GSDMD KRTAP27-1 0 0 172 240 1 1
GSDMD KRTAP2-3 0 0 148 172 1 1
GSDMD KRTAP10-2 0 0 167 185 1 1
GSDMD KRTAP23-1 0 0 174 173 1 1
GSDMD IRF7 0 0 451 510 1 1
GSDMD KRTAP7-1 0 0 134 227 1 1
GSDMD GBP3 0 0 170 218 1 1
GSDMD P2RX7 0 0 391 442 1 2
GSDMD ANO6 0 0 294 294 1 1
GSDMD PRF1 0 0 182 206 1 1
GSDMD KRT74 0 0 117 254 1 1
GSDMD GSDMB 0 0 654 275 1 1
GSDMD GPX4 0 0 297 297 1 2
GSDMD KRTAP2-4 0 0 158 182 1 1
GSDMD FAM136A 0 0 125 179 1 1
GSDMD IL1F10 0 0 142 215 1 1
GSDMD MAP1LC3B 0 0 149 166 1 2
GSDMD DFFB 0 0 216 216 1 1
GSDMD KRTAP4-2 0 0 155 173 1 1
GSDMD IFIH1 0 0 194 279 1 1
GSDMD DIABLO 0 0 218 218 1 2
GSDMD KRT77 0 0 81 223 1 1
GSDMD ELANE 0 0 261 261 1 1
GSDMD KRTAP9-9 0 0 150 187 1 1
GSDMD MAP3K12 0 0 270 270 1 1
GSDMD NOMO1 0 0 123 155 1 1
GSDMD TIGD5 0 0 211 211 1 1
GSDMD PKN1 0 0 181 200 1 1
GSDMD SLA 0 0 0 150 1 1
GSDMD KRTDAP 0 0 93 251 1 1
GSDMD GAL 0 0 0 173 1 1
GSDMD KRTAP5-2 0 0 142 160 1 1
GSDMD KRT82 0 0 125 260 1 1
GSDMD CXCR5 0 0 0 240 1 1
GSDMD EML3 0 0 0 154 1 1
GSDMD KRTAP9-7 0 0 165 202 1 1
GSDMD CTSB 0 0 324 325 1 2
GSDMD IL17A 0 0 181 181 1 2
GSDMD SPI1 0 0 125 186 1 1
GSDMD PRTN3 0 0 181 181 1 1
GSDMD EPPK1 0 0 82 172 1 1
GSDMD PCSK1 0 0 194 195 1 1
GSDMD CASP9 0 0 325 438 1 2
GSDMD IL18BP 0 0 134 165 1 1
GSDMD ITPR1 0 0 70 550 1 2
GSDMD COLGALT1 0 0 116 185 1 1
GSDMD ITGAM 0 0 230 261 1 1
GSDMD TRAF6 0 0 182 181 1 2
GSDMD DFNA5 0 0 816 379 1 1
GSDMD CYCS 0 0 294 294 1 2
GSDMD KRTAP19-4 0 0 174 173 1 1
GSDMD IFNB1 0 0 324 323 1 1
GSDMD HMGB1 0 0 402 505 1 2
GSDMD TLR7 0 0 181 228 1 2
GSDMD ATG5 0 0 170 169 1 2
GSDMD ENDOU 0 0 0 157 1 1
GSDMD KCTD6 733 0 0 733 1 1
GSDMD NLRP14 0 0 107 162 1 1
GSDMD ISG20 0 0 47 182 1 1
GSDMD TLR8 0 0 120 166 1 1
GSDMD KRTAP4-8 0 0 142 179 1 1
GSDMD IRF2 0 0 175 193 1 1
GSDMD IRF1 0 0 218 294 1 2
GSDMD MIB1 0 0 0 157 1 1
GSDMD KRTCAP3 0 0 134 268 1 1
GSDMD NLRP6 0 540 561 797 1 1
GSDMD NAA38 0 0 180 179 1 1
GSDMD GSDMC 0 0 684 215 1 1
GSDMD NEK7 0 0 605 613 1 1
GSDMD FBXL2 0 0 228 227 1 1
GSDMD KRTAP4-5 0 0 139 176 1 1
GSDMD CASP7 0 0 416 520 1 1
GSDMD CASP5 0 800 681 966 1 1
GSDMD KRTAP10-11 0 0 167 200 1 1
GSDMD CARD17 0 0 46 468 1 1
GSDMD ABRACL 0 0 128 184 1 1
GSDMD CD68 0 0 108 151 1 2
GSDMD CASP8 0 0 622 674 1 2
GSDMD ALB 0 0 179 215 1 2
GSDMD CCL2 0 0 208 219 1 2
GSDMD SDHA 0 0 75 171 1 1
GSDMD ZBTB33 252 0 0 252 1 1
GSDMD KRTAP2-2 0 0 150 174 1 1
GSDMD FAM49A 0 0 124 178 1 1
GSDMD NFKBIA 0 0 124 182 1 2
GSDMD SYK 0 0 241 276 1 2
GSDMD OLFML2B 0 0 95 151 1 1
GSDMD KRTAP10-9 0 0 174 207 1 1
GSDMD KRTAP12-2 0 0 159 198 1 1
GSDMD MB21D1 0 0 467 481 1 1
GSDMD SUGCT 0 0 74 245 1 1
GSDMD KRT6C 0 0 100 164 1 1
GSDMD AGER 0 0 181 198 1 2
GSDMD CTSG 0 0 229 248 1 1
GSDMD KRT72 0 0 60 206 1 1
GSDMD DDX58 0 0 365 378 1 1
GSDMD AIM2 0 720 788 939 1 2
GSDMD TRAT1 0 0 231 230 1 1
GSDMD MAVS 0 0 310 325 1 2
GSDMD IL1A 0 0 466 465 1 1
GSDMD GBP1 0 0 170 218 1 1
GSDMD KRTAP9-6 0 0 174 210 1 1
GSDMD KRTAP5-9 0 0 167 185 1 1
GSDMD TRADD 0 0 212 250 1 1
GSDMD C5orf15 0 0 166 218 1 1
GSDMD KRTAP13-3 0 0 141 200 1 1
GSDMD KRTAP20-3 0 0 174 173 1 1
GSDMD PSMB10 0 0 0 172 1 1
GSDMD KRTAP24-1 0 0 141 233 1 1
GSDMD IL10 0 0 228 227 1 2
GSDMD HBB 0 0 447 447 1 1
GSDMD HTR5A 0 0 160 305 1 1
GSDMD RNF31 0 0 165 183 1 1
GSDMD IRAK4 0 0 161 179 1 1
GSDMD UNC93B1 0 0 0 175 1 1
GSDMD CSF1 0 0 204 235 1 1
GSDMD KRTAP3-1 0 0 123 233 1 1
GSDMD RIPK1 0 0 556 566 1 2
GSDMD TRIM31 0 0 150 173 1 1
GSDMD NLRP9 0 720 322 868 1 1
GSDMD NOD2 0 0 287 312 1 2
GSDMD PTPRC 0 0 123 175 1 1
GSDMD XKR8 0 0 134 188 1 1
GSDMD ATG16L1 0 0 150 180 1 2
GSDMD MLKL 0 0 686 704 1 2
GSDMD BCL10 0 0 181 198 1 1
GSDMD RASA2 0 0 0 197 1 1
GSDMD KRTAP29-1 0 0 174 173 1 1
GSDMD KRTAP26-1 0 0 181 230 1 1
GSDMD KRTAP2-1 0 0 142 166 1 1
GSDMD KRTAP13-2 0 0 164 221 1 1
GSDMD IL1RAP 0 0 201 201 1 1
GSDMD KRT222 0 0 113 256 1 1
GSDMD TLR5 0 0 150 183 1 1
GSDMD CASZ1 0 0 93 173 1 1
GSDMD RHOA 0 0 181 181 1 2
GSDMD PARP1 0 0 175 180 1 2
GSDMD CASP4 847 800 593 993 1 2
GSDMD KRTAP1-4 0 0 167 203 1 1
GSDMD ZPBP2 0 0 103 193 1 1
GSDMD KRTAP10-4 0 0 171 204 1 1
GSDMD SQSTM1 0 0 156 230 1 2
GSDMD GRASP 0 0 74 322 1 1
GSDMD CYBB 0 0 162 201 1 2
GSDMD DPP7 0 0 113 217 1 1
GSDMD KRT78 0 0 96 236 1 1
GSDMD PSD4 0 0 0 185 1 1
GSDMD NLRX1 0 0 150 192 1 2
GSDMD GBP7 0 0 193 210 1 1
GSDMD KPRP 0 0 109 221 1 1
GSDMD KRTAP10-12 0 0 166 194 1 1
GSDMD CPD 0 0 0 179 1 1
GSDMD ACTB 0 0 328 339 1 2
GSDMD PANX2 0 0 95 208 1 1
GSDMD UPK3B 0 0 75 232 1 1
GSDMD KRTAP10-6 0 0 161 194 1 1
GSDMD CASP3 0 0 596 622 1 2
GSDMD IL33 0 0 232 231 1 2
GSDMD NCLN 0 0 125 198 1 1
GSDMD CXCL1 0 0 165 183 1 2
GSDMD IL21 0 0 0 300 1 1
GSDMD LRRC3 0 0 323 460 1 1
GSDMD NLRP3 0 800 805 965 1 2
GSDMD CARD16 0 0 52 497 1 1
GSDMD KRTAP21-1 0 0 157 156 1 1
GSDMD ITPR3 0 0 47 295 1 1
GSDMD SHARPIN 0 0 181 309 1 1
GSDMD DHX15 0 0 157 215 1 1
GSDMD TMEM173 0 0 189 466 1 1
GSDMD NOD1 0 0 181 224 1 2
GSDMD KRT76 0 0 112 167 1 1
GSDMD DPP9 0 0 335 438 1 1
GSDMD ENSG00000173366 0 0 244 260 1 1
GSDMD KRT80 0 0 82 187 1 1
GSDMD TLR2 0 0 285 319 1 2
GSDMD TNFSF10 0 0 150 181 1 2
GSDMD KRT79 0 0 171 238 1 1
GSDMD AIF1 0 0 173 197 1 2
GSDMD ORMDL3 0 0 155 165 1 2
GSDMD KRT40 0 0 117 254 1 1
GSDMD PADI4 0 0 216 233 1 1
GSDMD KRTAP9-8 0 0 151 188 1 1
GSDMD BECN1 0 0 218 218 1 2
GSDMD CASP1 800 800 953 998 1 2
GSDMD TLR6 0 0 81 160 1 1
GSDMD KRTAP4-3 0 0 137 185 1 1
GSDMD RAB39B 0 0 0 311 1 1
GSDMD KRTAP5-8 0 0 142 160 1 1
GSDMD RIPK2 0 0 181 204 1 2
GSDMD PKN2 0 0 184 215 1 1
GSDMD NATD1 0 0 235 315 1 1
GSDMD TCIRG1 0 0 0 178 1 1
GSDMD PSMB8 0 0 0 211 1 1
GSDMD KRTAP4-11 0 0 143 180 1 1
GSDMD CASP14 0 0 122 304 1 1
GSDMD USP50 0 0 180 179 1 1
GSDMD KRTAP19-5 0 0 155 154 1 1
GSDMD PKP4 0 0 72 166 1 1
GSDMD IL37 0 0 95 182 1 1
GSDMD IL36RN 0 0 45 199 1 1
GSDMD MIB2 0 0 0 157 1 1
GSDMD KRTAP10-3 0 0 167 200 1 1
GSDMD TICAM1 0 0 203 244 1 2
GSDMD FASLG 0 0 164 163 1 1
GSDMD MNDA 0 0 54 180 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:1901612 Molecular Function cardiolipin binding enables ISS
GO:0070300 Molecular Function phosphatidic acid binding enables ISS
GO:0005546 Molecular Function phosphatidylinositol-4,5-bisphosphate binding enables IBA
GO:0005546 Molecular Function phosphatidylinositol-4,5-bisphosphate binding enables IDA
GO:0070273 Molecular Function phosphatidylinositol-4-phosphate binding enables IBA
GO:0070273 Molecular Function phosphatidylinositol-4-phosphate binding enables IDA
GO:0001786 Molecular Function phosphatidylserine binding enables IBA
GO:0001786 Molecular Function phosphatidylserine binding enables ISS
GO:0005515 Molecular Function protein binding enables IPI
GO:0022829 Molecular Function wide pore channel activity enables IDA
GO:0031668 Biological Process cellular response to extracellular stimulus involved_in IEA
GO:0050829 Biological Process defense response to Gram-negative bacterium involved_in ISS
GO:0050830 Biological Process defense response to Gram-positive bacterium involved_in ISS
GO:0042742 Biological Process defense response to bacterium involved_in IBA
GO:0006954 Biological Process inflammatory response involved_in IEA
GO:0045087 Biological Process innate immune response involved_in IEA
GO:0046931 Biological Process pore complex assembly involved_in ISS
GO:0050729 Biological Process positive regulation of inflammatory response involved_in IDA
GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in ISS
GO:0051260 Biological Process protein homooligomerization involved_in ISS
GO:0009306 Biological Process protein secretion involved_in IDA
GO:0070269 Biological Process pyroptosis involved_in IBA
GO:0070269 Biological Process pyroptosis involved_in IDA
GO:0070269 Biological Process pyroptosis involved_in ISS
GO:0055085 Biological Process transmembrane transport involved_in IEA
GO:0072559 Cellular Component NLRP3 inflammasome complex part_of IBA
GO:0072559 Cellular Component NLRP3 inflammasome complex part_of ISS
GO:0005829 Cellular Component cytosol located_in ISS
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005576 Cellular Component extracellular region located_in TAS
GO:0005615 Cellular Component extracellular space located_in ISS
GO:1904813 Cellular Component ficolin-1-rich granule lumen located_in TAS
GO:0016020 Cellular Component membrane is_active_in IDA
GO:0031966 Cellular Component mitochondrial membrane located_in ISS
GO:0005654 Cellular Component nucleoplasm located_in IDA
GO:0005886 Cellular Component plasma membrane is_active_in IDA
GO:0005886 Cellular Component plasma membrane located_in ISS
GO:0035580 Cellular Component specific granule lumen located_in TAS
GO:1904724 Cellular Component tertiary granule lumen located_in TAS
Pathways
Name DB ID
Apoptosis Reactome R-HSA-109581
Intrinsic Pathway for Apoptosis Reactome R-HSA-109606
Release of apoptotic factors from the mitochondria Reactome R-HSA-111457
Apoptotic factor-mediated response Reactome R-HSA-111471
Cytokine Signaling in Immune system Reactome R-HSA-1280215
Disease Reactome R-HSA-1643685
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Toll-like Receptor Cascades Reactome R-HSA-168898
Interleukin-1 family signaling Reactome R-HSA-446652
Interleukin-1 processing Reactome R-HSA-448706
Signaling by Interleukins Reactome R-HSA-449147
Regulated Necrosis Reactome R-HSA-5218859
Programmed Cell Death Reactome R-HSA-5357801
Pyroptosis Reactome R-HSA-5620971
Infectious disease Reactome R-HSA-5663205
Regulation of TLR by endogenous ligand Reactome R-HSA-5686938
Neutrophil degranulation Reactome R-HSA-6798695
Leishmania infection Reactome R-HSA-9658195
Purinergic signaling in leishmaniasis infection Reactome R-HSA-9660826
Cell recruitment (pro-inflammatory response) Reactome R-HSA-9664424
Parasitic Infection Pathways Reactome R-HSA-9824443
STING pathway in Kawasaki-like disease and COVID-19 (WP4961) WikiPathways WP4961_r123345
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_001166237 1 mRNA transcript variant 2 NC_000008 Reference
NM_024736 7 mRNA transcript variant 1 NC_000008 Reference