CAPN2

calpain 2
General Information
Name calpain 2
Alias
  • calpain-2 catalytic subunit
  • CANP 2
  • M-calpain
  • calcium-activated neutral proteinase 2
  • calpain 2, (m/II) large subunit
  • calpain 2, large [catalytic] subunit
  • calpain 2, large subunit
  • calpain M-type
  • calpain, large polypeptide L2
  • millimolar-calpain
Synonyms mCANP CANPml CANPL2 CANP2
Gene_family EF-hand domain containing|Calpains
organism Homo sapiens
entrez_id 824
location 1q41
transcript_count 3
exon_count 23
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
      Stringdb Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity); Calpains
      nextProt Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    CAPN2 BioGRID MEX3A GeneID BioGRID Affinity Capture-RNA
    CAPN2 BioGRID S GeneID BioGRID Proximity Label-MS
    CAPN2 BioGRID KCTD7 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
    CAPN2 BioGRID CUL3 GeneID BioGRID Affinity Capture-Western
    CAPN2 BioGRID RPL10A GeneID BioGRID Cross-Linking-MS (XL-MS)
    CAPN2 BioGRID PDHX GeneID BioGRID Cross-Linking-MS (XL-MS)
    CAPN2 BioGRID MAPT GeneID BioGRID Affinity Capture-MS; Biochemical Activity
    CAPN2 BioGRID CFTR GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID UBE2H GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID RPA3 GeneID BioGRID Proximity Label-MS
    CAPN2 BioGRID RPA1 GeneID BioGRID Proximity Label-MS
    CAPN2 BioGRID CAPN3 GeneID BioGRID Negative Genetic
    CAPN2 BioGRID CAPN1 GeneID BioGRID Affinity Capture-MS; Negative Genetic
    CAPN2 BioGRID CAPN11 GeneID BioGRID Negative Genetic
    CAPN2 BioGRID CAPN9 GeneID BioGRID Negative Genetic
    CAPN2 BioGRID CAPN12 GeneID BioGRID Negative Genetic
    CAPN2 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID RUFY1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID CCNF GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    CAPN2 BioGRID HSPA8 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID HSPA1A GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID MALAT1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID PRKN GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID SSU72 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID BICD2 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID TUBA1B GeneID BioGRID Co-fractionation
    CAPN2 BioGRID RBM8A GeneID BioGRID Co-fractionation
    CAPN2 BioGRID EIF3G GeneID BioGRID Co-fractionation
    CAPN2 BioGRID HSP90B1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID TPM4 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID TBCD GeneID BioGRID Co-fractionation
    CAPN2 BioGRID SPTAN1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID PSMA1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID COPB1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID CHD4 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID CAPNS1 GeneID BioGRID Affinity Capture-MS; Co-crystal Structure; Co-fractionation
    CAPN2 BioGRID ACTN1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID BCCIP GeneID BioGRID Co-fractionation
    CAPN2 BioGRID C9orf78 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID PARP1 GeneID BioGRID Proximity Label-MS
    CAPN2 BioGRID PMS1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID PIK3C2A GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID MYO9A GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID LSP1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID FNTB GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID FNTA GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID DMWD GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID CAST GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID CFAP410 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID FMN2 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID SMG8 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID MKS1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID ERCC6L GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID CCZ1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID MTO1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID TUT4 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID CSTF2T GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID TASOR GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID PPIP5K2 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID WDR37 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID POLR3A GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID B3GNT2 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID RPL23 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID OFD1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID PIP5K1A GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID LZTR1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID NPRL3 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID TOP2A GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID STAT2 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID FAM9C GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID USP54 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID CD109 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID WDR36 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID DOCK7 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID MCM8 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID DIAPH3 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID AFG2B GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID SPANXN4 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID EIF2AK4 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID TEDC1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID HTRA4 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID COPS5 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID BRD4 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID DUX4 GeneID BioGRID Reconstituted Complex
    CAPN2 BioGRID CAV1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID LACTB GeneID BioGRID Proximity Label-MS
    CAPN2 BioGRID IMMP2L GeneID BioGRID Proximity Label-MS
    CAPN2 BioGRID ENG GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID LMBR1L GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID PLK1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID GSK3B GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID PTP4A2 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID DYRK1A GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID DUSP28 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID CSK GeneID BioGRID Synthetic Lethality
    CAPN2 BioGRID ZFYVE21 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    CAPN2 BioGRID MTDH GeneID BioGRID Protein-RNA
    CAPN2 BioGRID PBXIP1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    CAPN2 BioGRID VIRMA GeneID BioGRID Affinity Capture-RNA
    CAPN2 BioGRID MYC GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID STUB1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID EFTUD2 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID ATXN3 GeneID BioGRID Biochemical Activity
    CAPN2 BioGRID EGLN3 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID GNS GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID PSG8 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID DUSP19 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID FBXL12 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID JAK3 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID CHORDC1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID NTRK1 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID MAN2A2 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID DNASE2B GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID ATG5 GeneID BioGRID Biochemical Activity
    CAPN2 BioGRID ZDHHC17 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    CAPN2 BioGRID UBE2I GeneID BioGRID Affinity Capture-Western
    CAPN2 BioGRID DCP2 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID TUBB2A GeneID BioGRID Co-fractionation
    CAPN2 BioGRID SNRPE GeneID BioGRID Co-fractionation
    CAPN2 BioGRID PCYT2 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID PTMA GeneID BioGRID Co-fractionation
    CAPN2 BioGRID PAFAH1B1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID MSN GeneID BioGRID Co-fractionation
    CAPN2 BioGRID HK1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID GMDS GeneID BioGRID Co-fractionation
    CAPN2 BioGRID CTH GeneID BioGRID Co-fractionation
    CAPN2 BioGRID ALDH7A1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID ATIC GeneID BioGRID Co-fractionation
    CAPN2 BioGRID ASNS GeneID BioGRID Co-fractionation
    CAPN2 BioGRID TATDN1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID NSFL1C GeneID BioGRID Co-fractionation
    CAPN2 BioGRID STK26 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID UBXN1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID TWF2 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID PLPBP GeneID BioGRID Co-fractionation
    CAPN2 BioGRID PDIA4 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID PAPSS1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID UBA3 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID NAE1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID YWHAE GeneID BioGRID Co-fractionation
    CAPN2 BioGRID XPO1 GeneID BioGRID Co-fractionation
    CAPN2 BioGRID TUFM GeneID BioGRID Co-fractionation
    CAPN2 BioGRID SOX2 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID MAPK1 GeneID BioGRID Biochemical Activity
    CAPN2 BioGRID ECT2 GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID CEBPA GeneID BioGRID Affinity Capture-MS
    CAPN2 BioGRID HNRNPA1 GeneID BioGRID Affinity Capture-MS
    CAPN2 Protein CAPNS2 GeneID HPRD None
    CAPN2 Protein CDK5R1 GeneID HPRD None
    CAPN2 Protein GAS2 GeneID HPRD None
    CAPN2 Protein CASP9 GeneID HPRD None
    CAPN2 Protein F2RL1 GeneID HPRD None
    CAPN2 Protein TNS1 GeneID HPRD None
    CAPN2 Protein KNG1 GeneID HPRD None
    CAPN2 Protein PTPN1 GeneID HPRD None
    CAPN2 Protein NFKBIA GeneID HPRD None
    CAPN2 Protein NMT1 GeneID HPRD None
    CAPN2 Protein CAPNS1 GeneID HPRD None
    CAPN2 Protein GRK2 GeneID HPRD None
    CAPN2 BioGRID PTPRN GeneID BioGRID Biochemical Activity
    CAPN2 BioGRID BID GeneID BioGRID Biochemical Activity
    CAPN2 BioGRID BCL2 GeneID BioGRID Biochemical Activity; Reconstituted Complex
    StringDB
    A B experiments database textmining combined score hadb nhadb
    CAPN2 CKAP5 0 0 53 204 1 1
    CAPN2 CREB1 0 0 146 187 1 1
    CAPN2 LMOD3 0 0 94 181 1 1
    CAPN2 ZDHHC17 270 0 0 285 1 1
    CAPN2 RPS27L 0 0 67 193 1 1
    CAPN2 WNT11 0 0 390 394 1 1
    CAPN2 ZFX 0 0 0 186 1 1
    CAPN2 LPCAT1 0 0 0 217 1 1
    CAPN2 IQGAP1 0 0 123 158 1 1
    CAPN2 GSTM3 0 0 0 303 1 1
    CAPN2 CAPN15 0 0 402 354 1 1
    CAPN2 CASP6 42 0 263 278 1 1
    CAPN2 CIAPIN1 0 0 67 549 1 1
    CAPN2 EVPL 0 0 0 226 1 1
    CAPN2 TMBIM4 0 0 202 202 1 1
    CAPN2 GAPDH 0 0 340 354 1 2
    CAPN2 CRYGS 0 0 150 220 1 1
    CAPN2 MAP2K7 0 0 108 162 1 1
    CAPN2 POSTN 0 0 112 153 1 1
    CAPN2 NEDD4 0 0 108 274 1 2
    CAPN2 FBXL12 270 0 0 293 1 1
    CAPN2 SUMO2 0 0 82 193 1 1
    CAPN2 CTSL 0 0 324 345 1 1
    CAPN2 WNT7A 0 0 410 410 1 1
    CAPN2 CTNNB1 0 0 181 186 1 1
    CAPN2 MYF5 0 0 107 165 1 1
    CAPN2 HRAS 0 0 104 160 1 1
    CAPN2 APP 0 650 224 725 1 1
    CAPN2 WNT2B 0 0 414 420 1 1
    CAPN2 PMM1 0 0 108 162 1 1
    CAPN2 RRAS 0 0 91 176 1 1
    CAPN2 GCA 0 0 0 215 1 1
    CAPN2 CPEB3 0 0 241 273 1 1
    CAPN2 MMP1 0 0 63 159 1 1
    CAPN2 MTOR 0 0 213 232 1 2
    CAPN2 ENDOG 0 0 241 240 1 1
    CAPN2 KCNMA1 0 0 44 162 1 1
    CAPN2 MYH14 0 0 194 238 1 1
    CAPN2 TGM2 0 0 112 179 1 1
    CAPN2 TP53 0 800 216 837 1 2
    CAPN2 RASEF 0 0 151 236 1 1
    CAPN2 EPS15 0 0 118 153 1 1
    CAPN2 GMDS 244 0 0 485 1 1
    CAPN2 LAMP1 0 0 90 153 1 2
    CAPN2 ANKFY1 0 0 90 194 1 1
    CAPN2 HTT 0 0 163 226 1 1
    CAPN2 CRYGB 0 0 142 157 1 1
    CAPN2 ZYG11A 0 0 0 150 1 1
    CAPN2 EGFR 0 0 184 229 1 1
    CAPN2 PEF1 0 0 0 218 1 1
    CAPN2 METTL12 0 0 0 151 1 1
    CAPN2 MXD4 0 0 149 207 1 1
    CAPN2 CAPNS2 213 600 134 869 1 1
    CAPN2 WNT4 0 0 306 313 1 1
    CAPN2 PTPN4 0 0 77 447 1 1
    CAPN2 APAF1 0 0 124 194 1 1
    CAPN2 CLU 0 0 71 187 1 2
    CAPN2 CALM3 0 0 135 225 1 1
    CAPN2 PCYT2 129 0 0 456 1 1
    CAPN2 ADCY1 0 0 113 217 1 1
    CAPN2 CISD2 0 0 183 188 1 2
    CAPN2 ITGA5 0 0 94 211 1 1
    CAPN2 MYH6 0 0 150 180 1 1
    CAPN2 TCEA1 0 0 48 293 1 1
    CAPN2 GNS 130 0 0 263 1 1
    CAPN2 TLN1 0 900 452 957 1 1
    CAPN2 WNT5A 0 0 306 328 1 1
    CAPN2 ILK 0 0 122 174 1 1
    CAPN2 LGMN 0 0 123 166 1 1
    CAPN2 FA2H 0 0 0 186 1 1
    CAPN2 CDS2 0 0 131 166 1 1
    CAPN2 P4HB 62 0 71 295 1 2
    CAPN2 TMBIM6 0 0 94 150 1 1
    CAPN2 EFTUD2 240 0 0 239 1 1
    CAPN2 WDR64 0 0 0 213 1 1
    CAPN2 ARHGEF28 0 0 167 187 1 1
    CAPN2 CPO 0 0 87 168 1 1
    CAPN2 MICU1 0 0 0 262 1 1
    CAPN2 FLNA 0 0 303 343 1 1
    CAPN2 TTN 0 0 219 358 1 1
    CAPN2 MYL9 0 0 113 177 1 1
    CAPN2 LMBR1L 270 0 0 274 1 1
    CAPN2 SSR1 0 0 74 242 1 1
    CAPN2 CYB5D1 0 0 0 175 1 1
    CAPN2 AREG 0 0 62 269 1 1
    CAPN2 RHPN2 0 0 0 174 1 1
    CAPN2 NDUFS7 0 0 150 155 1 1
    CAPN2 DIABLO 0 0 139 234 1 1
    CAPN2 GZF1 0 0 0 186 1 1
    CAPN2 CALML4 0 0 113 346 1 1
    CAPN2 PTK2 0 900 767 976 1 1
    CAPN2 MAPK8 0 0 141 182 1 2
    CAPN2 PRKAR1B 0 0 71 156 1 1
    CAPN2 PPP3R2 0 0 107 166 1 1
    CAPN2 MAP2K4 0 0 70 239 1 1
    CAPN2 GABBR2 0 0 137 158 1 1
    CAPN2 CYCS 0 0 319 334 1 1
    CAPN2 PTPN3 0 0 0 189 1 1
    CAPN2 ATP5A1 0 0 141 159 1 1
    CAPN2 PLAU 0 0 101 220 1 1
    CAPN2 EGF 0 0 207 222 1 1
    CAPN2 HSPA4 0 0 170 169 1 1
    CAPN2 ATL3 0 0 0 241 1 1
    CAPN2 PLAUR 0 0 71 234 1 1
    CAPN2 HSPB3 0 0 172 243 1 1
    CAPN2 HSP90B1 0 0 166 173 1 1
    CAPN2 PCDHA4 0 0 102 158 1 1
    CAPN2 ATP6V1D 0 0 0 390 1 1
    CAPN2 ALB 0 0 193 208 1 1
    CAPN2 CAPN6 0 0 496 308 1 1
    CAPN2 BAIAP3 0 0 181 181 1 1
    CAPN2 SPTBN4 0 0 60 158 1 1
    CAPN2 CASP7 0 0 293 317 1 1
    CAPN2 MME 0 0 48 165 1 1
    CAPN2 CDK5 0 650 323 777 1 2
    CAPN2 ELMO1 0 0 0 187 1 1
    CAPN2 WNT9B 0 0 440 440 1 1
    CAPN2 CACNG7 0 0 103 204 1 1
    CAPN2 FER1L6 0 0 0 273 1 1
    CAPN2 TMOD4 0 0 53 157 1 1
    CAPN2 CTH 244 0 0 486 1 1
    CAPN2 WNT16 0 0 359 359 1 1
    CAPN2 TWF1 0 0 0 191 1 1
    CAPN2 DUSP10 0 0 167 407 1 1
    CAPN2 CDH1 0 0 162 161 1 1
    CAPN2 TBC1D2 0 0 57 191 1 1
    CAPN2 MAP3K11 0 0 296 307 1 1
    CAPN2 ZYX 0 0 218 247 1 1
    CAPN2 ATP2A1 0 0 150 192 1 1
    CAPN2 GBP1 0 0 0 171 1 1
    CAPN2 PPP1CB 0 0 108 426 1 1
    CAPN2 ZER1 0 0 0 212 1 1
    CAPN2 PARVB 0 0 0 184 1 1
    CAPN2 KPNA5 0 0 108 169 1 1
    CAPN2 ITGAV 0 0 112 222 1 1
    CAPN2 HUNK 0 0 138 209 1 1
    CAPN2 ZNF711 0 0 0 151 1 1
    CAPN2 LCTL 0 0 295 502 1 1
    CAPN2 AR 0 0 146 232 1 1
    CAPN2 BID 270 800 72 897 1 1
    CAPN2 ENSG00000249884 0 0 0 153 1 1
    CAPN2 CDKN1A 0 0 113 150 1 2
    CAPN2 BAX 0 800 122 816 1 2
    CAPN2 TIMP1 0 0 103 180 1 1
    CAPN2 ARHGDIA 0 0 108 251 1 1
    CAPN2 MSN 129 0 150 478 1 1
    CAPN2 SQSTM1 0 0 162 186 1 2
    CAPN2 PCK2 0 0 328 342 1 1
    CAPN2 KCNF1 0 0 0 177 1 1
    CAPN2 MMP9 0 0 242 246 1 1
    CAPN2 MAPK3 0 900 354 948 1 2
    CAPN2 PSG8 257 0 0 256 1 1
    CAPN2 S100A11 0 0 109 171 1 1
    CAPN2 ZNF514 0 0 65 150 1 1
    CAPN2 HSP90AA1 0 0 359 373 1 2
    CAPN2 ASS1 0 0 0 213 1 1
    CAPN2 PSEN1 0 0 150 209 1 2
    CAPN2 PTGDR2 0 0 430 430 1 1
    CAPN2 SOX2 270 0 55 280 1 1
    CAPN2 MYH7B 0 0 142 179 1 1
    CAPN2 DPYSL2 0 0 156 254 1 1
    CAPN2 WDR31 0 0 261 324 1 1
    CAPN2 JUN 0 0 212 242 1 1
    CAPN2 DNTT 0 0 208 208 1 1
    CAPN2 ECE2 0 0 0 242 1 1
    CAPN2 SELK 0 0 181 216 1 1
    CAPN2 JAK3 168 0 49 188 1 1
    CAPN2 LSP1 257 0 60 271 1 1
    CAPN2 ERC2 0 0 66 163 1 1
    CAPN2 EIF2AK2 0 0 137 217 1 2
    CAPN2 PCDHA7 0 0 101 157 1 1
    CAPN2 TAGLN3 0 0 0 190 1 1
    CAPN2 PPM1F 0 0 0 226 1 1
    CAPN2 CPEB2 0 0 167 217 1 1
    CAPN2 PRKACB 0 0 0 171 1 1
    CAPN2 GRIN2A 0 0 181 237 1 1
    CAPN2 FYN 0 900 134 911 1 1
    CAPN2 PPHLN1 0 0 108 233 1 1
    CAPN2 CASQ1 0 0 84 165 1 1
    CAPN2 SMC1A 0 0 50 168 1 1
    CAPN2 MNT 0 0 60 162 1 1
    CAPN2 SMC3 0 0 42 208 1 1
    CAPN2 SOD1 0 0 108 184 1 1
    CAPN2 SPTBN1 0 0 234 286 1 1
    CAPN2 HSP90AB1 0 0 58 176 1 2
    CAPN2 PTPN23 0 0 0 174 1 1
    CAPN2 PPP3CA 0 0 202 224 1 1
    CAPN2 MYH4 0 0 171 189 1 1
    CAPN2 GPR160 0 0 108 198 1 1
    CAPN2 UBQLN1 0 0 45 183 1 2
    CAPN2 NVL 0 0 154 153 1 1
    CAPN2 MYOF 0 0 108 297 1 1
    CAPN2 NID2 0 0 74 174 1 1
    CAPN2 SLC25A23 0 0 0 165 1 1
    CAPN2 YES1 0 900 46 902 1 1
    CAPN2 PPM1E 0 0 0 226 1 1
    CAPN2 ECE1 0 0 0 180 1 1
    CAPN2 PSMC1 0 0 210 274 1 1
    CAPN2 USP53 0 0 91 166 1 1
    CAPN2 AIFM1 0 0 174 301 1 1
    CAPN2 ITM2B 0 0 0 175 1 1
    CAPN2 VCAM1 0 0 111 165 1 1
    CAPN2 DERL2 0 0 73 176 1 1
    CAPN2 SUMO1 270 0 81 376 1 1
    CAPN2 DYSF 0 0 181 335 1 1
    CAPN2 WEE2 0 0 99 161 1 1
    CAPN2 SHC2 0 0 161 161 1 1
    CAPN2 PSMD5 0 0 0 183 1 1
    CAPN2 ABHD15 0 0 166 499 1 1
    CAPN2 XRRA1 0 0 165 165 1 1
    CAPN2 NTRK2 0 0 129 274 1 1
    CAPN2 SDF2 0 0 0 234 1 1
    CAPN2 COL4A2 0 0 44 155 1 1
    CAPN2 ZNF789 0 0 0 157 1 1
    CAPN2 TUBB2A 129 0 0 159 1 1
    CAPN2 CACNA1A 0 0 124 196 1 1
    CAPN2 RFPL4A 0 0 164 173 1 1
    CAPN2 TAF5L 0 0 125 246 1 1
    CAPN2 CDC42 0 0 149 195 1 1
    CAPN2 UAP1L1 0 0 0 155 1 1
    CAPN2 SLC2A4 0 0 145 164 1 1
    CAPN2 FOXO3 0 0 193 193 1 2
    CAPN2 APOE 0 0 142 195 1 1
    CAPN2 S100A6 0 0 75 235 1 1
    CAPN2 HDHD1 0 0 123 266 1 1
    CAPN2 DBNL 0 0 147 232 1 1
    CAPN2 ATG3 0 0 193 193 1 2
    CAPN2 CAMK2D 0 0 88 211 1 1
    CAPN2 CHMP4B 0 0 0 268 1 2
    CAPN2 CRLF1 0 0 218 274 1 1
    CAPN2 TP53INP2 0 0 107 171 1 2
    CAPN2 CCND1 0 0 136 210 1 1
    CAPN2 TXNDC11 0 0 0 171 1 1
    CAPN2 UBE2I 270 0 84 419 1 1
    CAPN2 WNT9A 0 0 330 330 1 1
    CAPN2 ANXA2 0 0 160 274 1 1
    CAPN2 ACTN1 0 0 234 298 1 1
    CAPN2 SDPR 0 0 72 170 1 1
    CAPN2 MICU2 0 0 0 175 1 1
    CAPN2 MYH2 0 0 171 206 1 1
    CAPN2 ATP2A2 0 0 81 159 1 1
    CAPN2 SYNM 0 0 74 180 1 1
    CAPN2 UAP1 0 0 92 268 1 1
    CAPN2 CAPRIN1 0 0 0 158 1 1
    CAPN2 HTRA4 270 0 0 318 1 1
    CAPN2 TXN 0 0 57 159 1 1
    CAPN2 S100A10 0 0 95 224 1 1
    CAPN2 FH 0 0 0 191 1 1
    CAPN2 CASP2 0 0 150 325 1 1
    CAPN2 STRN3 0 0 0 403 1 1
    CAPN2 JPH2 0 0 193 216 1 1
    CAPN2 BDNF 0 0 259 264 1 2
    CAPN2 RNF25 0 0 161 161 1 1
    CAPN2 MYF6 0 0 150 187 1 1
    CAPN2 DDX3X 0 0 0 190 1 1
    CAPN2 ABHD17A 0 0 0 183 1 1
    CAPN2 CHMP2A 0 0 0 153 1 2
    CAPN2 GLS2 0 0 0 173 1 1
    CAPN2 VCL 0 0 384 426 1 1
    CAPN2 SDF2L1 0 0 0 171 1 1
    CAPN2 NFE2L3 0 0 55 471 1 1
    CAPN2 METTL13 0 0 0 151 1 1
    CAPN2 CDR2L 0 0 218 228 1 1
    CAPN2 SYNE1 0 0 88 280 1 1
    CAPN2 NEDD4L 0 0 0 167 1 1
    CAPN2 MAPK1 270 900 218 958 1 2
    CAPN2 ITGA3 0 0 147 220 1 1
    CAPN2 IGF1 0 0 164 163 1 1
    CAPN2 EXOC3L2 0 0 0 156 1 1
    CAPN2 ESRRB 0 0 0 188 1 1
    CAPN2 MYOZ1 0 0 95 176 1 1
    CAPN2 DNASE2B 178 0 120 292 1 1
    CAPN2 DYRK1A 486 0 90 561 1 1
    CAPN2 HSPB1 0 0 202 283 1 1
    CAPN2 HSPB2 0 0 186 238 1 1
    CAPN2 NEB 0 0 210 310 1 1
    CAPN2 HSPB4 0 0 0 159 1 1
    CAPN2 GAL 0 0 47 252 1 1
    CAPN2 CHMP6 0 0 0 155 1 1
    CAPN2 NUCB1 0 0 0 205 1 1
    CAPN2 NUDC 0 0 195 195 1 1
    CAPN2 TMED8 0 0 0 153 1 1
    CAPN2 MYL3 0 0 72 151 1 1
    CAPN2 PPP1CA 0 0 46 221 1 1
    CAPN2 RBBP4 0 0 0 199 1 1
    CAPN2 CTSB 0 0 295 339 1 2
    CAPN2 CAPNS1 871 900 905 995 1 2
    CAPN2 XBP1 0 0 181 186 1 2
    CAPN2 SMC1B 0 0 0 160 1 1
    CAPN2 PTPN1 270 0 235 417 1 1
    CAPN2 MAP2K6 0 0 0 171 1 1
    CAPN2 KSR1 270 0 0 282 1 1
    CAPN2 ATG5 270 0 299 466 1 2
    CAPN2 VGLL1 0 0 72 200 1 1
    CAPN2 CAMK2G 0 0 0 170 1 1
    CAPN2 YIPF1 0 0 171 171 1 1
    CAPN2 ITGB3 0 0 101 253 1 1
    CAPN2 AGPS 0 0 0 152 1 1
    CAPN2 MYOD1 0 0 155 183 1 1
    CAPN2 DNM1L 0 0 113 160 1 2
    CAPN2 D2HGDH 0 0 0 390 1 1
    CAPN2 VEGFA 0 0 193 208 1 1
    CAPN2 TXN2 0 0 91 502 1 1
    CAPN2 MAPK7 0 0 62 188 1 1
    CAPN2 PTEN 0 0 164 176 1 2
    CAPN2 MBP 0 0 141 159 1 1
    CAPN2 CFL1 0 0 144 215 1 1
    CAPN2 PAPSS1 263 0 0 263 1 1
    CAPN2 MAPK14 0 0 96 337 1 1
    CAPN2 TP53BP2 0 0 141 168 1 1
    CAPN2 CAPN7 0 0 601 328 1 1
    CAPN2 UCP1 0 0 294 294 1 1
    CAPN2 TCF4 0 0 0 200 1 1
    CAPN2 ASAP2 0 0 194 296 1 1
    CAPN2 PTRF 0 0 83 228 1 1
    CAPN2 NFKBIA 213 0 124 383 1 1
    CAPN2 CPNE4 0 0 104 165 1 1
    CAPN2 MAST4 0 0 125 234 1 1
    CAPN2 KLK6 0 0 108 203 1 1
    CAPN2 CTSD 0 0 218 302 1 2
    CAPN2 TRIM63 0 0 373 380 1 1
    CAPN2 EZR 0 0 219 312 1 1
    CAPN2 ATM 0 0 57 157 1 1
    CAPN2 BPNT1 0 0 126 259 1 1
    CAPN2 PIEZO1 0 0 260 299 1 1
    CAPN2 ITGB4 0 0 135 232 1 1
    CAPN2 COL1A1 0 0 108 152 1 1
    CAPN2 CRYBB1 0 0 124 161 1 1
    CAPN2 ATG7 0 0 294 325 1 2
    CAPN2 ITGB5 0 0 0 170 1 1
    CAPN2 ACTG1 0 0 139 196 1 1
    CAPN2 CRYAB 0 0 113 202 1 1
    CAPN2 YWHAH 0 0 112 163 1 1
    CAPN2 CAPN10 0 0 601 386 1 2
    CAPN2 CALM2 0 0 72 168 1 1
    CAPN2 CASP4 0 0 218 243 1 2
    CAPN2 SUSD4 0 0 203 219 1 1
    CAPN2 MYH1 0 0 143 161 1 1
    CAPN2 ZNF433 0 0 202 248 1 1
    CAPN2 WNT2 0 0 364 371 1 1
    CAPN2 PTPN5 0 0 113 172 1 1
    CAPN2 ATG12 0 0 230 240 1 2
    CAPN2 SPON2 0 0 0 161 1 1
    CAPN2 ESRRG 0 0 0 254 1 1
    CAPN2 ZFYVE21 270 0 0 270 1 1
    CAPN2 ARPC5 0 0 74 326 1 1
    CAPN2 MYH8 0 0 156 174 1 1
    CAPN2 NBEA 0 0 181 181 1 1
    CAPN2 PPIC 0 0 142 163 1 1
    CAPN2 OS9 0 0 0 212 1 1
    CAPN2 HSPB8 0 0 60 160 1 2
    CAPN2 MMP14 0 0 113 174 1 1
    CAPN2 CTPS2 0 0 107 300 1 1
    CAPN2 GPR45 0 0 112 201 1 1
    CAPN2 CAV3 0 0 125 182 1 1
    CAPN2 CDK5R1 213 900 156 934 1 1
    CAPN2 PPP1R3A 0 0 0 153 1 1
    CAPN2 PDIA3 0 0 45 240 1 1
    CAPN2 MALRD1 0 0 146 178 1 1
    CAPN2 MAN2A2 272 0 0 277 1 1
    CAPN2 MICU3 0 0 0 175 1 1
    CAPN2 ADCY10 0 0 54 169 1 1
    CAPN2 LRRK2 270 0 0 290 1 2
    CAPN2 GRIN2B 0 0 170 205 1 1
    CAPN2 HSPA5 0 0 334 334 1 2
    CAPN2 DTNB 0 0 100 165 1 1
    CAPN2 TLN2 0 800 157 867 1 1
    CAPN2 FOXO1 0 0 108 197 1 2
    CAPN2 ADRBK1 213 0 43 221 1 1
    CAPN2 CNDP2 0 0 0 196 1 1
    CAPN2 MSTN 0 0 194 200 1 1
    CAPN2 PRKACA 0 0 74 199 1 1
    CAPN2 TENC1 0 0 435 439 1 1
    CAPN2 PSMA1 0 0 97 173 1 1
    CAPN2 GRIA2 0 0 162 253 1 1
    CAPN2 FLNC 0 0 141 184 1 1
    CAPN2 CS 0 0 0 190 1 1
    CAPN2 WNT8A 0 0 485 485 1 1
    CAPN2 ANXA5 0 0 229 309 1 1
    CAPN2 TAGLN 0 0 69 222 1 1
    CAPN2 ASCC2 0 0 156 171 1 1
    CAPN2 FBXO32 0 0 391 390 1 2
    CAPN2 PHEX 0 0 0 158 1 1
    CAPN2 PRDX6 0 0 74 277 1 1
    CAPN2 PHLPP1 0 0 234 280 1 1
    CAPN2 RAN 55 0 0 154 1 1
    CAPN2 KCNIP4 0 0 217 340 1 1
    CAPN2 BCL2L1 0 0 234 234 1 2
    CAPN2 ATIC 245 0 0 485 1 2
    CAPN2 BFSP2 0 0 162 161 1 1
    CAPN2 RAP1A 0 0 155 175 1 1
    CAPN2 WNT7B 0 0 360 360 1 1
    CAPN2 NAE1 245 0 66 484 1 1
    CAPN2 IL1B 0 0 150 169 1 1
    CAPN2 ANKRD23 0 0 132 201 1 1
    CAPN2 CAPN5 0 0 603 296 1 1
    CAPN2 MAPK13 0 0 74 199 1 1
    CAPN2 KIAA1429 270 0 0 286 1 1
    CAPN2 SELENBP1 0 0 0 194 1 1
    CAPN2 CNTD2 0 0 134 236 1 1
    CAPN2 BFSP1 0 0 242 257 1 1
    CAPN2 MAP1LC3A 0 0 140 200 1 2
    CAPN2 SHMT2 0 0 60 316 1 1
    CAPN2 LDHD 0 0 0 152 1 1
    CAPN2 NMT1 270 0 0 321 1 1
    CAPN2 PLA2G4A 0 0 126 168 1 1
    CAPN2 XPO1 129 0 0 161 1 1
    CAPN2 PRICKLE1 0 0 103 172 1 1
    CAPN2 STAP2 0 0 0 213 1 1
    CAPN2 CALM1 0 0 124 215 1 1
    CAPN2 SUMO4 0 0 0 157 1 1
    CAPN2 NUDCD1 270 0 0 270 1 1
    CAPN2 IL6 0 0 167 167 1 1
    CAPN2 ABHD12 0 0 0 150 1 1
    CAPN2 TNFRSF1A 0 0 123 165 1 1
    CAPN2 MYOG 0 0 193 210 1 1
    CAPN2 ACTN4 0 0 143 215 1 1
    CAPN2 ABHD17B 0 0 0 183 1 1
    CAPN2 CFTR 64 0 68 151 1 1
    CAPN2 ARPC2 0 0 166 182 1 1
    CAPN2 HK2 0 0 57 273 1 1
    CAPN2 GOLIM4 0 0 134 171 1 1
    CAPN2 DDIT3 0 0 261 283 1 2
    CAPN2 PRKX 0 0 0 193 1 1
    CAPN2 PRKACG 0 0 0 171 1 1
    CAPN2 GLI4 0 0 124 175 1 1
    CAPN2 WNT5B 0 0 431 437 1 1
    CAPN2 MESDC2 0 0 0 213 1 1
    CAPN2 PDCD6 0 0 142 269 1 1
    CAPN2 TATDN1 245 0 0 485 1 1
    CAPN2 MED23 0 0 108 356 1 1
    CAPN2 ERN1 0 0 173 186 1 2
    CAPN2 PYCR1 0 0 0 156 1 1
    CAPN2 RHPN1 0 0 0 174 1 1
    CAPN2 DDAH2 0 0 96 434 1 1
    CAPN2 CAPN13 0 0 390 278 1 1
    CAPN2 KLB 0 0 0 183 1 1
    CAPN2 MYC 66 0 193 219 1 2
    CAPN2 CHMP4C 0 0 0 268 1 1
    CAPN2 OR52J3 0 0 195 318 1 1
    CAPN2 WFS1 0 0 241 288 1 1
    CAPN2 IGF1R 0 0 106 173 1 1
    CAPN2 GLS 0 0 0 173 1 1
    CAPN2 MYH10 0 0 187 254 1 1
    CAPN2 GLDC 0 0 72 359 1 1
    CAPN2 STRN4 0 0 0 249 1 1
    CAPN2 PPP3CB 0 0 162 176 1 1
    CAPN2 FLG2 0 0 134 159 1 1
    CAPN2 PARVA 0 0 0 208 1 1
    CAPN2 ZNF473 0 0 118 169 1 1
    CAPN2 MOB4 0 0 0 193 1 1
    CAPN2 PPP3CC 0 0 112 181 1 1
    CAPN2 FHL2 0 0 180 347 1 1
    CAPN2 SRI 0 0 67 219 1 1
    CAPN2 NUPR1 274 0 0 274 1 1
    CAPN2 SAMD4B 0 0 134 188 1 1
    CAPN2 CYB5A 0 0 0 324 1 1
    CAPN2 DOLK 0 0 0 168 1 1
    CAPN2 F2RL1 213 0 0 213 1 1
    CAPN2 RPS27 0 0 0 171 1 1
    CAPN2 TNS1 270 0 74 301 1 1
    CAPN2 PXN 0 900 363 937 1 1
    CAPN2 CTGF 0 0 57 173 1 1
    CAPN2 KCTD20 0 0 151 158 1 1
    CAPN2 SUMO3 0 0 0 157 1 1
    CAPN2 VIM 0 0 123 189 1 1
    CAPN2 HLX 0 0 67 229 1 1
    CAPN2 KLHL29 0 0 134 552 1 1
    CAPN2 HK1 129 0 0 232 1 1
    CAPN2 CASP9 213 0 309 466 1 1
    CAPN2 ITPR1 0 0 319 341 1 2
    CAPN2 KCTD3 0 0 124 447 1 1
    CAPN2 DIEXF 0 0 113 189 1 1
    CAPN2 RDX 0 0 150 369 1 1
    CAPN2 ITGA1 0 900 0 902 1 1
    CAPN2 HSPE1-MOB4 0 0 0 193 1 1
    CAPN2 CASP8 0 0 664 684 1 2
    CAPN2 KNG1 213 0 48 224 1 1
    CAPN2 ITGB1 0 900 147 927 1 1
    CAPN2 ENPP2 0 0 85 287 1 1
    CAPN2 OR51A7 0 0 193 270 1 1
    CAPN2 ARPC1A 0 0 107 203 1 1
    CAPN2 MYLK 0 0 112 162 1 1
    CAPN2 CTBS 0 0 126 186 1 1
    CAPN2 EXOC3L4 0 0 56 176 1 1
    CAPN2 BLMH 0 0 68 357 1 1
    CAPN2 FRMD4B 0 0 0 151 1 1
    CAPN2 C4orf46 0 0 234 234 1 1
    CAPN2 UBXN1 244 0 0 243 1 1
    CAPN2 FBXO28 0 0 208 416 1 1
    CAPN2 PPP2R5A 0 0 155 164 1 1
    CAPN2 IL1A 0 800 108 814 1 1
    CAPN2 CHMP3 0 0 0 153 1 1
    CAPN2 IAPP 0 0 154 243 1 1
    CAPN2 ESR2 0 0 75 178 1 1
    CAPN2 PTPRN 270 0 0 277 1 1
    CAPN2 PROSC 129 0 0 444 1 1
    CAPN2 MYH9 0 0 176 239 1 1
    CAPN2 RHOA 0 0 267 279 1 1
    CAPN2 ZYG11B 0 0 0 150 1 1
    CAPN2 NSFL1C 245 0 0 413 1 1
    CAPN2 ITGB7 0 0 0 160 1 1
    CAPN2 WNT6 0 0 398 398 1 1
    CAPN2 ENSG00000255835 0 0 0 156 1 1
    CAPN2 CTTN 0 0 294 328 1 1
    CAPN2 STUB1 270 0 64 312 1 2
    CAPN2 EXOC3 0 0 0 221 1 1
    CAPN2 INS 0 0 247 246 1 1
    CAPN2 ACTB 0 0 339 384 1 1
    CAPN2 CAPN12 0 0 764 304 1 1
    CAPN2 KEAP1 0 0 46 205 1 2
    CAPN2 ABHD12B 0 0 0 150 1 1
    CAPN2 ANKRD2 0 0 142 214 1 1
    CAPN2 ALDOB 0 0 58 329 1 1
    CAPN2 HPGDS 0 0 574 574 1 1
    CAPN2 PDIA2 0 0 90 213 1 1
    CAPN2 TFEB 0 0 134 161 1 2
    CAPN2 CEBPA 270 0 71 305 1 1
    CAPN2 ACTN3 0 0 126 179 1 1
    CAPN2 UNC45A 0 0 91 198 1 1
    CAPN2 BCL2L11 0 0 112 287 1 1
    CAPN2 TNKS 0 0 0 243 1 1
    CAPN2 MAPK12 0 0 0 170 1 1
    CAPN2 KL 0 0 329 428 1 1
    CAPN2 ITPR3 0 0 261 302 1 1
    CAPN2 TMEM220 0 0 181 181 1 1
    CAPN2 KLK8 0 0 167 266 1 1
    CAPN2 SNCA 0 0 113 155 1 2
    CAPN2 CASP1 0 0 160 180 1 2
    CAPN2 MB21D2 0 0 134 292 1 1
    CAPN2 GPR161 0 0 0 189 1 1
    CAPN2 MST4 244 0 0 277 1 1
    CAPN2 CAV1 117 0 240 347 1 1
    CAPN2 MAP2K3 0 0 0 171 1 1
    CAPN2 CYB5B 0 0 0 324 1 1
    CAPN2 PPL 0 0 66 336 1 1
    CAPN2 SAE1 0 0 73 301 1 1
    CAPN2 CALR 0 0 125 158 1 1
    CAPN2 ERLEC1 0 0 0 171 1 1
    CAPN2 COIL 0 0 0 241 1 1
    CAPN2 MMP2 0 0 245 276 1 1
    CAPN2 PSMD1 0 0 171 171 1 1
    CAPN2 YWHAE 129 0 53 158 1 1
    CAPN2 LCK 0 900 0 901 1 1
    CAPN2 LAMP2 0 0 107 150 1 2
    CAPN2 SLC25A24 0 0 0 181 1 1
    CAPN2 CABLES1 0 0 0 199 1 1
    CAPN2 P4HA3 0 0 90 155 1 1
    CAPN2 GAS2 213 0 72 255 1 1
    CAPN2 ITGB6 0 0 0 160 1 1
    CAPN2 NID1 0 0 46 167 1 1
    CAPN2 CTSC 0 0 73 166 1 1
    CAPN2 ERBB2 0 0 173 173 1 2
    CAPN2 SLC16A7 0 0 49 259 1 1
    CAPN2 ATF4 0 0 163 218 1 2
    CAPN2 PRKCG 0 0 113 196 1 1
    CAPN2 PRSS46 0 0 405 445 1 1
    CAPN2 CARD8 0 0 70 227 1 1
    CAPN2 TWF2 263 0 0 425 1 1
    CAPN2 ZMAT3 0 0 62 445 1 1
    CAPN2 FKRP 0 0 0 187 1 1
    CAPN2 AKT1 0 0 370 404 1 2
    CAPN2 CAPN1 184 800 912 838 1 2
    CAPN2 XIAP 0 0 170 210 1 1
    CAPN2 ASNS 129 0 0 442 1 1
    CAPN2 ATL2 0 0 82 382 1 1
    CAPN2 KLF4 0 0 54 150 1 1
    CAPN2 ATF6 0 0 207 222 1 2
    CAPN2 B3GNT2 275 0 0 275 1 1
    CAPN2 GABRE 0 0 66 210 1 1
    CAPN2 MESDC1 0 0 0 169 1 1
    CAPN2 UBA3 245 0 0 450 1 1
    CAPN2 CHMP4A 0 0 0 268 1 1
    CAPN2 BIN1 0 0 60 170 1 1
    CAPN2 EPB41 0 0 134 166 1 1
    CAPN2 DHCR24 0 0 0 152 1 1
    CAPN2 DCP2 218 0 0 227 1 1
    CAPN2 RBP1 0 0 54 200 1 1
    CAPN2 SMURF2 0 0 0 216 1 1
    CAPN2 SRC 0 900 484 947 1 1
    CAPN2 EED 0 0 0 181 1 1
    CAPN2 NEXN 0 0 112 167 1 1
    CAPN2 SYAP1 0 0 141 159 1 1
    CAPN2 EEA1 0 0 107 256 1 1
    CAPN2 DGAT2 0 0 52 233 1 1
    CAPN2 SPTAN1 0 0 557 596 1 1
    CAPN2 ENSG00000160202 0 0 0 159 1 1
    CAPN2 EIF2AK3 0 0 212 251 1 2
    CAPN2 ABHD17C 0 0 0 183 1 1
    CAPN2 HSPA9 0 0 112 181 1 1
    CAPN2 ERC1 0 0 92 203 1 1
    CAPN2 NTRK1 63 0 96 155 1 1
    CAPN2 RPS6KB1 0 0 172 188 1 2
    CAPN2 AHNAK 0 0 54 210 1 1
    CAPN2 FAM129B 0 0 204 271 1 1
    CAPN2 WNT8B 0 0 456 456 1 1
    CAPN2 QSOX1 0 0 213 351 1 1
    CAPN2 MEPCE 0 0 183 197 1 1
    CAPN2 BCL2 270 0 0 270 1 2
    CAPN2 BAK1 0 800 137 826 1 2
    CAPN2 MLC1 0 900 0 902 1 1
    CAPN2 DNAJB2 0 0 134 228 1 1
    CAPN2 CHORDC1 135 0 0 170 1 1
    CAPN2 PRKCDBP 0 0 93 156 1 1
    CAPN2 PSMA3 0 0 73 163 1 1
    CAPN2 DEK 0 0 52 178 1 1
    CAPN2 ELMO2 0 0 0 187 1 1
    CAPN2 WNT10B 0 0 398 398 1 1
    CAPN2 FRMD4A 0 0 81 667 1 1
    CAPN2 CANX 0 0 108 154 1 2
    CAPN2 GRIA1 0 0 140 207 1 1
    CAPN2 ALDH5A1 0 0 63 400 1 1
    CAPN2 CAST 621 800 968 999 1 1
    CAPN2 FAIM 0 0 95 233 1 1
    CAPN2 ANKRD1 0 0 51 163 1 1
    CAPN2 PTMA 245 0 0 244 1 1
    CAPN2 LCT 0 0 0 323 1 1
    CAPN2 TNF 0 0 157 179 1 1
    CAPN2 RBBP7 0 0 0 199 1 1
    CAPN2 ALDH7A1 129 0 0 406 1 1
    CAPN2 PDCD6IP 0 0 55 186 1 1
    CAPN2 ERCC3 0 0 59 180 1 1
    CAPN2 REST 0 0 60 168 1 1
    CAPN2 ATG4B 0 0 194 236 1 2
    CAPN2 PYCR2 0 0 0 156 1 1
    CAPN2 STRN 0 0 81 406 1 1
    CAPN2 CDH5 0 0 136 177 1 1
    CAPN2 SLC25A25 0 0 0 165 1 1
    CAPN2 LAMA1 0 0 385 398 1 1
    CAPN2 ITM2A 0 0 0 164 1 1
    CAPN2 MAP1LC3B 0 0 181 182 1 2
    CAPN2 TIMP2 0 0 134 183 1 1
    CAPN2 GUCY1A2 0 0 108 178 1 1
    CAPN2 GBP3 0 0 0 172 1 1
    CAPN2 FN1 0 0 279 300 1 1
    CAPN2 PLAA 0 0 91 272 1 1
    CAPN2 PRKCA 0 0 151 166 1 1
    CAPN2 CAMK2A 0 0 74 156 1 2
    CAPN2 CSRP1 0 0 107 153 1 1
    CAPN2 EXOC3L1 0 0 0 156 1 1
    CAPN2 ESR1 0 0 108 160 1 1
    CAPN2 ACBD3 0 0 108 380 1 1
    CAPN2 PBXIP1 270 0 181 381 1 1
    CAPN2 ENSG00000100926 0 0 0 270 1 1
    CAPN2 TNFAIP2 0 0 0 176 1 1
    CAPN2 MMEL1 0 0 0 158 1 1
    CAPN2 ENSG00000273398 0 0 0 189 1 1
    CAPN2 ENG 270 0 0 285 1 1
    CAPN2 GOT2 0 0 45 263 1 1
    CAPN2 AMPH 0 0 86 225 1 1
    CAPN2 PPP3R1 0 0 69 270 1 1
    CAPN2 CDR2 0 0 116 186 1 1
    CAPN2 DMD 0 0 123 230 1 1
    CAPN2 WNT10A 0 0 434 434 1 1
    CAPN2 DLG4 0 0 102 150 1 1
    CAPN2 PDIA4 244 0 54 524 1 1
    CAPN2 ATG16L1 0 0 123 194 1 2
    CAPN2 PEPD 0 0 65 209 1 1
    CAPN2 WNT3 0 0 358 365 1 1
    CAPN2 PTGES3 0 0 45 436 1 1
    CAPN2 DUX4 270 0 0 270 1 1
    CAPN2 GSK3B 105 0 85 251 1 2
    CAPN2 ITPKB 0 0 124 178 1 1
    CAPN2 TMOD1 0 0 99 180 1 1
    CAPN2 MYH7 0 0 150 188 1 1
    CAPN2 ZBTB34 0 0 56 198 1 1
    CAPN2 LMO7 0 0 139 184 1 1
    CAPN2 PRELID1 0 0 643 643 1 1
    CAPN2 SMURF1 0 0 84 330 1 1
    CAPN2 CASP3 0 0 602 616 1 2
    CAPN2 ADGB 0 0 282 282 1 1
    CAPN2 PSMD2 0 0 122 162 1 1
    CAPN2 CYB5R4 0 0 0 160 1 1
    CAPN2 MAPT 270 0 203 393 1 2
    CAPN2 BECN1 0 0 284 284 1 2
    CAPN2 PSENEN 0 0 95 153 1 1
    CAPN2 ANXA1 0 0 95 193 1 1
    CAPN2 MAPK11 0 0 54 306 1 1
    CAPN2 ATXN3 488 0 218 583 1 1
    CAPN2 ITGB2 0 0 0 179 1 1
    CAPN2 KRAS 0 0 81 194 1 1
    CAPN2 KCNG1 0 0 0 214 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005509 Molecular Function calcium ion binding enables IEA
    GO:0004198 Molecular Function calcium-dependent cysteine-type endopeptidase activity enables IBA
    GO:0004198 Molecular Function calcium-dependent cysteine-type endopeptidase activity enables IDA
    GO:0004198 Molecular Function calcium-dependent cysteine-type endopeptidase activity enables ISS
    GO:0004198 Molecular Function calcium-dependent cysteine-type endopeptidase activity enables TAS
    GO:0008234 Molecular Function cysteine-type peptidase activity enables TAS
    GO:0008092 Molecular Function cytoskeletal protein binding enables NAS
    GO:0019899 Molecular Function enzyme binding enables IEA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0044877 Molecular Function protein-containing complex binding enables IEA
    GO:0048266 Biological Process behavioral response to pain involved_in IEA
    GO:0001824 Biological Process blastocyst development involved_in IEA
    GO:0071230 Biological Process cellular response to amino acid stimulus involved_in ISS
    GO:0035458 Biological Process cellular response to interferon-beta involved_in IEA
    GO:0071222 Biological Process cellular response to lipopolysaccharide involved_in IEA
    GO:0007565 Biological Process female pregnancy involved_in IEA
    GO:0007520 Biological Process myoblast fusion involved_in IEA
    GO:0010666 Biological Process positive regulation of cardiac muscle cell apoptotic process involved_in IEA
    GO:1901741 Biological Process positive regulation of myoblast fusion involved_in IEA
    GO:2001247 Biological Process positive regulation of phosphatidylcholine biosynthetic process involved_in IEA
    GO:0016540 Biological Process protein autoprocessing involved_in IEA
    GO:0140249 Biological Process protein catabolic process at postsynapse involved_in IEA
    GO:0006508 Biological Process proteolysis involved_in IBA
    GO:0006508 Biological Process proteolysis involved_in ISS
    GO:0006508 Biological Process proteolysis involved_in NAS
    GO:0051603 Biological Process proteolysis involved in protein catabolic process involved_in IDA
    GO:0051493 Biological Process regulation of cytoskeleton organization involved_in TAS
    GO:0032675 Biological Process regulation of interleukin-6 production involved_in IEA
    GO:0042542 Biological Process response to hydrogen peroxide involved_in IEA
    GO:0001666 Biological Process response to hypoxia involved_in IEA
    GO:0009612 Biological Process response to mechanical stimulus involved_in IEA
    GO:0048488 Biological Process synaptic vesicle endocytosis involved_in IEA
    GO:0097700 Biological Process vascular endothelial cell response to laminar fluid shear stress involved_in TAS
    GO:0097706 Biological Process vascular endothelial cell response to oscillatory fluid shear stress involved_in TAS
    GO:0005794 Cellular Component Golgi apparatus located_in IDA
    GO:0110158 Cellular Component calpain complex part_of IPI
    GO:0000785 Cellular Component chromatin located_in IEA
    GO:0030864 Cellular Component cortical actin cytoskeleton located_in TAS
    GO:0005737 Cellular Component cytoplasm is_active_in IBA
    GO:0005737 Cellular Component cytoplasm located_in ISS
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0030425 Cellular Component dendrite located_in ISS
    GO:0005783 Cellular Component endoplasmic reticulum located_in IDA
    GO:0009897 Cellular Component external side of plasma membrane located_in IEA
    GO:0070062 Cellular Component extracellular exosome located_in HDA
    GO:0005925 Cellular Component focal adhesion located_in HDA
    GO:0005764 Cellular Component lysosome located_in IEA
    GO:0045121 Cellular Component membrane raft colocalizes_with IDA
    GO:0045121 Cellular Component membrane raft located_in IDA
    GO:0043025 Cellular Component neuronal cell body located_in IEA
    GO:0005634 Cellular Component nucleus located_in IEA
    GO:0097038 Cellular Component perinuclear endoplasmic reticulum located_in IDA
    GO:0005886 Cellular Component plasma membrane located_in IDA
    GO:0005886 Cellular Component plasma membrane located_in TAS
    GO:0098794 Cellular Component postsynapse located_in IEA
    GO:0098793 Cellular Component presynapse located_in IEA
    GO:0031143 Cellular Component pseudopodium located_in IDA
    Pathways
    Name DB ID
    Degradation of the extracellular matrix Reactome R-HSA-1474228
    Extracellular matrix organization Reactome R-HSA-1474244
    Disease Reactome R-HSA-1643685
    Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Reactome R-HSA-8862803
    Neurodegenerative Diseases Reactome R-HSA-8863678
    Diseases of programmed cell death Reactome R-HSA-9645723
    Defective Intrinsic Pathway for Apoptosis Reactome R-HSA-9734009
    Focal adhesion (WP306) WikiPathways WP306_r116784
    Integrin-mediated cell adhesion (WP185) WikiPathways WP185_r116785
    Alzheimer's disease (WP5124) WikiPathways WP5124_r123917
    Alzheimer's disease and miRNA effects (WP2059) WikiPathways WP2059_r119468
    VEGFA-VEGFR2 signaling pathway (WP3888) WikiPathways WP3888_r116782
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_001146068 2 mRNA transcript variant 2 NC_000001 Reference
    NM_001748 5 mRNA transcript variant 1 NC_000001 Reference
    XM_047431344 1 mRNA transcript variant X1 NC_000001 Reference