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CAST

calpastatin
General Information
Name calpastatin
Alias
  • calpastatin
  • calpain inhibitor
  • sperm BS-17 component
Gene_family
organism Homo sapiens
entrez_id 831
location 5q15
transcript_count 36
exon_count 49
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
    Stringdb Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family
    nextProt Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
CAST BioGRID Rab18 GeneID BioGRID Proximity Label-MS
CAST BioGRID TBK1 GeneID BioGRID Proximity Label-MS
CAST BioGRID STAU1 GeneID BioGRID Proximity Label-MS
CAST BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
CAST BioGRID MST1R GeneID BioGRID Proximity Label-MS
CAST BioGRID CCNF GeneID BioGRID Proximity Label-MS
CAST BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
CAST BioGRID BAP1 GeneID BioGRID Affinity Capture-MS
CAST BioGRID PABPC1 GeneID BioGRID Co-fractionation
CAST BioGRID STRAP GeneID BioGRID Co-fractionation
CAST BioGRID NUDC GeneID BioGRID Co-fractionation
CAST BioGRID CCT7 GeneID BioGRID Co-fractionation
CAST BioGRID TJP2 GeneID BioGRID Co-fractionation
CAST BioGRID TPR GeneID BioGRID Co-fractionation
CAST BioGRID SNRPD3 GeneID BioGRID Co-fractionation
CAST BioGRID S100A2 GeneID BioGRID Co-fractionation
CAST BioGRID RPA1 GeneID BioGRID Co-fractionation
CAST BioGRID RARS1 GeneID BioGRID Co-fractionation
CAST BioGRID PPP2R5D GeneID BioGRID Co-fractionation
CAST BioGRID PLS3 GeneID BioGRID Co-fractionation
CAST BioGRID ILF3 GeneID BioGRID Co-fractionation
CAST BioGRID HSP90AB1 GeneID BioGRID Co-fractionation
CAST BioGRID HSPB1 GeneID BioGRID Co-fractionation
CAST BioGRID HSPA9 GeneID BioGRID Co-fractionation
CAST BioGRID HSPA6 GeneID BioGRID Co-fractionation
CAST BioGRID HSPA1A GeneID BioGRID Co-fractionation
CAST BioGRID HNRNPA2B1 GeneID BioGRID Co-fractionation
CAST BioGRID H1-2 GeneID BioGRID Co-fractionation
CAST BioGRID GSTM3 GeneID BioGRID Co-fractionation
CAST BioGRID PDIA3 GeneID BioGRID Co-fractionation
CAST BioGRID FLNB GeneID BioGRID Co-fractionation
CAST BioGRID ACLY GeneID BioGRID Co-fractionation
CAST BioGRID CAPN8 GeneID BioGRID Affinity Capture-MS
CAST BioGRID CAPNS2 GeneID BioGRID Affinity Capture-MS
CAST BioGRID NAA40 GeneID BioGRID Proximity Label-MS
CAST BioGRID STX17 GeneID BioGRID Affinity Capture-MS
CAST BioGRID MTUS2 GeneID BioGRID Affinity Capture-MS
CAST BioGRID GOT1 GeneID BioGRID Affinity Capture-MS
CAST BioGRID FNTB GeneID BioGRID Affinity Capture-MS
CAST BioGRID FGB GeneID BioGRID Affinity Capture-MS
CAST BioGRID CAPN2 GeneID BioGRID Affinity Capture-MS
CAST BioGRID CAPN1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure
CAST BioGRID FZR1 GeneID BioGRID Affinity Capture-MS
CAST BioGRID SUMO2 GeneID BioGRID Reconstituted Complex
CAST BioGRID NONO GeneID BioGRID Affinity Capture-RNA
CAST BioGRID PRNP GeneID BioGRID Affinity Capture-MS
CAST BioGRID RSL1D1 GeneID BioGRID Proximity Label-MS
CAST BioGRID HMGN2 GeneID BioGRID Proximity Label-MS
CAST BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
CAST BioGRID GSK3B GeneID BioGRID Affinity Capture-MS
CAST BioGRID DYNC1LI2 GeneID BioGRID Proximity Label-MS
CAST BioGRID CSK GeneID BioGRID Synthetic Lethality
CAST BioGRID DCAF15 GeneID BioGRID Proximity Label-MS
CAST BioGRID PTRH2 GeneID BioGRID Proximity Label-MS
CAST BioGRID VIRMA GeneID BioGRID Affinity Capture-MS; Affinity Capture-RNA
CAST BioGRID EZR GeneID BioGRID Proximity Label-MS
CAST BioGRID PIH1D1 GeneID BioGRID Affinity Capture-MS
CAST BioGRID EFTUD2 GeneID BioGRID Affinity Capture-MS
CAST BioGRID CFTR GeneID BioGRID Affinity Capture-MS
CAST BioGRID HNRNPL GeneID BioGRID Affinity Capture-RNA
CAST BioGRID CDH1 GeneID BioGRID Proximity Label-MS
CAST BioGRID Kif13b GeneID BioGRID Affinity Capture-MS
CAST BioGRID BAG6 GeneID BioGRID Affinity Capture-MS
CAST BioGRID LZIC GeneID BioGRID Co-fractionation
CAST BioGRID PPME1 GeneID BioGRID Co-fractionation
CAST BioGRID CRK GeneID BioGRID Co-fractionation
CAST BioGRID CKB GeneID BioGRID Co-fractionation
CAST BioGRID PPP4R3A GeneID BioGRID Co-fractionation
CAST BioGRID COPS4 GeneID BioGRID Co-fractionation
CAST BioGRID COPS5 GeneID BioGRID Co-fractionation
CAST BioGRID RPP38 GeneID BioGRID Co-fractionation
CAST BioGRID SART3 GeneID BioGRID Co-fractionation
CAST BioGRID CUL4A GeneID BioGRID Co-fractionation
CAST BioGRID PSMB7 GeneID BioGRID Co-fractionation
CAST BioGRID PSMB5 GeneID BioGRID Co-fractionation
CAST BioGRID PSMB3 GeneID BioGRID Co-fractionation
CAST BioGRID PSMA6 GeneID BioGRID Co-fractionation
CAST BioGRID PSMA5 GeneID BioGRID Co-fractionation
CAST BioGRID KIF5B GeneID BioGRID Co-fractionation
CAST BioGRID EPB41L1 GeneID BioGRID Co-fractionation
CAST BioGRID LRBA GeneID BioGRID Co-fractionation
CAST BioGRID PSIP1 GeneID BioGRID Co-fractionation
CAST BioGRID ELAVL1 GeneID BioGRID Affinity Capture-RNA
CAST BioGRID POL1 GeneID BioGRID Affinity Capture-Western
CAST BioGRID PCLAF GeneID BioGRID Affinity Capture-Western
CAST Protein PPFIA4 GeneID HPRD
CAST Protein PPFIA1 GeneID HPRD
CAST Protein PPFIA3 GeneID HPRD
CAST Protein PPFIA2 GeneID HPRD
CAST Protein HTRA1 GeneID HPRD
CAST Protein CASP7 GeneID HPRD
CAST Protein CASP3 GeneID HPRD
CAST Protein CASP1 GeneID HPRD
CAST Protein CAPN1 GeneID HPRD
CAST Protein CAPNS1 GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
CAST NMNAT2 0 0 208 296 1 1
CAST CMPK2 0 0 0 167 1 1
CAST WNT10A 0 0 486 485 1 1
CAST ATG7 0 0 143 231 1 2
CAST MARCKS 0 0 181 181 1 1
CAST PSMB2 0 0 62 169 1 1
CAST DMD 0 0 294 316 1 2
CAST FNDC1 0 0 0 203 1 1
CAST SIMC1 0 0 181 181 1 1
CAST MTDH 0 0 81 204 1 2
CAST NCK1 118 0 50 228 1 1
CAST PSMB7 245 0 62 348 1 1
CAST PRKAG3 0 0 371 409 1 1
CAST EZR 78 0 234 279 1 1
CAST RYR1 0 0 270 283 1 2
CAST TRIM63 0 0 378 378 1 1
CAST CTSD 0 0 375 388 1 2
CAST WNT16 0 0 397 396 1 1
CAST TRIM54 0 0 165 165 1 1
CAST HDAC8 0 0 0 209 1 1
CAST NEFL 0 0 234 350 1 1
CAST NFKBIA 0 0 269 285 1 2
CAST LEP 0 0 161 183 1 1
CAST VSX1 0 0 140 162 1 1
CAST ZNRF1 0 0 74 171 1 1
CAST WNT9B 0 0 497 497 1 1
CAST UCP1 0 0 307 307 1 2
CAST CAPN7 0 0 600 779 1 1
CAST CDK5 0 650 451 803 1 2
CAST LZIC 272 0 0 272 1 1
CAST ACSM1 0 0 0 188 1 1
CAST CASP7 213 0 275 424 1 1
CAST STMN2 0 0 81 150 1 1
CAST MBP 0 0 308 313 1 2
CAST SNPH 0 0 99 155 1 1
CAST KIAA0101 270 0 0 270 1 1
CAST ITGB1 0 900 0 902 1 1
CAST SPTBN4 0 0 157 168 1 1
CAST VEGFA 0 0 173 173 1 2
CAST GPR68 0 0 108 200 1 1
CAST SPACA1 0 0 241 240 1 1
CAST CCL2 0 0 134 225 1 2
CAST CASP8 0 0 344 361 1 2
CAST CAPN6 0 0 520 848 1 1
CAST ALB 0 0 253 252 1 2
CAST LEPR 0 0 125 270 1 1
CAST MYOD1 0 0 162 180 1 1
CAST DPYSL3 0 0 70 198 1 1
CAST SYP 0 0 321 321 1 1
CAST SLC8A3 0 0 242 294 1 1
CAST YIPF1 0 0 230 254 1 1
CAST PDE6B 0 0 247 246 1 1
CAST ATG5 0 0 269 343 1 2
CAST ITGA1 0 900 0 900 1 1
CAST HSPB3 0 0 195 201 1 1
CAST CTSH 0 0 113 168 1 1
CAST PTPN1 0 0 170 181 1 1
CAST ACSF3 0 0 95 157 1 1
CAST RPL23 0 0 0 190 1 1
CAST CYP1B1 0 0 142 227 1 1
CAST RPP38 244 0 0 243 1 1
CAST CAPNS1 462 800 806 986 1 2
CAST PMEL 0 0 0 260 1 1
CAST HSPA4 0 0 255 254 1 1
CAST SMEK1 129 0 0 152 1 1
CAST UBE4B 0 0 108 210 1 1
CAST CDH22 0 0 74 187 1 1
CAST PCSK1 0 0 156 178 1 1
CAST PPFIA3 213 0 0 267 1 1
CAST EGF 0 0 158 157 1 2
CAST SERBP1 0 0 66 169 1 1
CAST CTSB 0 0 459 474 1 2
CAST IGFBP1 0 0 75 152 1 1
CAST OFCC1 0 0 46 158 1 1
CAST SMARCA5 0 0 0 169 1 1
CAST COPS5 244 0 54 254 1 1
CAST CYCS 0 0 391 392 1 2
CAST BACE1 0 0 202 202 1 2
CAST ITPR1 0 0 233 238 1 2
CAST VCAN 0 0 358 358 1 1
CAST CASP9 0 0 394 401 1 2
CAST ULK1 0 0 118 153 1 2
CAST NUDC 272 0 0 272 1 1
CAST KLF16 0 0 0 189 1 1
CAST STMN1 0 0 96 169 1 1
CAST PRKCA 0 0 163 163 1 1
CAST SHISA2 0 0 102 180 1 1
CAST MARCH3 0 0 95 195 1 1
CAST QARS 0 0 0 303 1 1
CAST PTK2 0 900 148 911 1 2
CAST NMNAT3 0 0 123 245 1 1
CAST FN1 0 0 235 251 1 2
CAST MT-ND6 0 0 69 164 1 1
CAST NEB 0 0 468 480 1 1
CAST HSPB2 0 0 193 243 1 1
CAST PRNP 0 0 124 167 1 2
CAST HSPB1 0 0 207 358 1 2
CAST FLG 0 0 286 286 1 1
CAST CST4 0 0 150 155 1 1
CAST SRL 0 0 125 221 1 1
CAST PXN 0 900 213 919 1 1
CAST DIABLO 0 0 184 183 1 2
CAST DFFB 0 0 137 157 1 1
CAST TIMP2 0 0 143 166 1 1
CAST MAP1LC3B 0 0 155 171 1 2
CAST LAMA1 0 0 398 398 1 1
CAST MYOZ1 0 0 136 171 1 1
CAST SNAP91 0 0 642 642 1 1
CAST TNIP2 0 0 66 321 1 1
CAST MSTN 0 0 358 384 1 1
CAST TPP2 0 0 388 388 1 1
CAST SPTBN1 0 0 48 152 1 1
CAST NCK2 0 0 66 155 1 1
CAST SOD1 0 0 261 261 1 2
CAST CSTA 0 0 52 151 1 1
CAST NME4 0 0 74 214 1 1
CAST GALNT14 0 0 0 194 1 1
CAST RPL39 0 0 94 213 1 1
CAST LAMP2 0 0 134 184 1 2
CAST CAPN2 621 800 968 999 1 2
CAST FYN 118 0 75 206 1 1
CAST GRIN2A 0 0 155 154 1 1
CAST CHI3L2 0 0 142 177 1 1
CAST FOS 0 0 152 151 1 2
CAST PENK 0 0 57 157 1 1
CAST MMP2 0 0 184 201 1 2
CAST CAPN8 733 0 391 924 1 1
CAST CRK 302 0 45 304 1 1
CAST FOXO1 0 0 136 166 1 2
CAST ZDHHC5 270 0 0 270 1 1
CAST NOS1AP 0 0 0 227 1 1
CAST EPAS1 0 0 0 182 1 2
CAST SAE1 0 0 61 265 1 1
CAST ADAM8 0 0 0 250 1 1
CAST MYH13 0 0 155 162 1 1
CAST ERC2 0 0 233 272 1 1
CAST LSP1 0 0 50 539 1 1
CAST ITFG1 0 0 162 161 1 1
CAST HSPA5 0 0 194 195 1 2
CAST GRIN2B 0 0 156 155 1 1
CAST PADI4 0 0 170 169 1 1
CAST ATXN3 0 0 310 327 1 2
CAST SELK 0 0 136 154 1 1
CAST CWF19L1 0 0 150 284 1 1
CAST ANXA1 0 0 105 184 1 1
CAST INA 0 0 124 258 1 1
CAST LEPROTL1 0 0 96 338 1 1
CAST CASP1 213 0 235 400 1 2
CAST SNCA 0 0 234 245 1 2
CAST MAPT 0 0 232 231 1 2
CAST BECN1 0 0 195 202 1 2
CAST MOCS3 0 0 0 190 1 1
CAST DNTT 0 0 156 155 1 1
CAST FABP3 0 0 170 195 1 1
CAST ACAD11 0 0 91 150 1 1
CAST SIGMAR1 0 0 181 206 1 1
CAST SERPINB4 0 0 253 252 1 1
CAST CAPN9 0 0 602 853 1 1
CAST ITPR3 0 0 212 231 1 1
CAST JUN 0 0 233 232 1 2
CAST CAV3 0 0 150 168 1 1
CAST CDK5R1 0 900 241 923 1 1
CAST DPYSL2 0 0 162 184 1 1
CAST KL 0 0 384 384 1 2
CAST SLC8A2 0 0 134 225 1 1
CAST EARS2 0 0 0 167 1 1
CAST ACTR3 0 0 0 154 1 1
CAST EIF2S3 0 0 90 165 1 1
CAST ADGB 0 0 51 270 1 1
CAST SP100 0 0 47 289 1 1
CAST CASP3 213 0 563 655 1 2
CAST ACTN3 0 0 90 186 1 1
CAST PSMA2 0 0 60 183 1 1
CAST HTRA2 0 0 113 168 1 1
CAST PTGS2 0 0 142 161 1 2
CAST PSEN1 0 0 184 183 1 2
CAST ARNTL2 0 0 54 190 1 1
CAST RANGAP1 0 0 42 255 1 1
CAST MMP14 0 0 125 159 1 1
CAST PARS2 0 0 0 161 1 1
CAST HSP90AA1 0 0 296 300 1 2
CAST CALHM1 0 0 107 301 1 1
CAST ANKRD2 0 0 90 338 1 1
CAST HNRNPL 270 0 0 270 1 1
CAST MAPK3 0 0 182 181 1 2
CAST MMP9 0 0 170 169 1 2
CAST CSTB 0 0 135 170 1 1
CAST CUL4A 129 0 0 217 1 1
CAST CAPN12 0 0 413 594 1 1
CAST PCK2 0 0 359 359 1 1
CAST PPME1 272 0 0 275 1 1
CAST TMOD3 0 0 0 188 1 1
CAST ACTB 0 0 325 343 1 2
CAST NCAPG 0 0 75 230 1 1
CAST INS 0 0 261 261 1 2
CAST ATG12 0 0 112 167 1 2
CAST MSN 0 0 161 181 1 1
CAST NEFH 0 0 213 287 1 1
CAST PSMA5 245 0 60 426 1 1
CAST KIF2A 0 0 52 166 1 1
CAST EPRS 0 0 48 625 1 1
CAST RPL31 0 0 87 213 1 1
CAST TNNT1 0 0 200 200 1 1
CAST WNT6 0 0 414 414 1 1
CAST MYL1 0 0 177 233 1 1
CAST RCAN2 0 0 0 396 1 1
CAST ANGPTL3 0 0 0 303 1 1
CAST TNNI3 0 0 218 218 1 1
CAST WNT2 0 0 397 396 1 1
CAST CMTM1 0 0 133 187 1 1
CAST GSK3B 105 0 204 282 1 2
CAST RAB24 0 0 84 180 1 2
CAST ZFYVE20 0 0 161 161 1 1
CAST AR 0 0 171 171 1 2
CAST PARP1 0 0 213 213 1 2
CAST CASP4 0 0 108 165 1 2
CAST RHOA 0 0 181 265 1 2
CAST GSN 0 0 167 185 1 1
CAST CAPN10 0 0 594 776 1 2
CAST EIF4G1 0 0 162 161 1 2
CAST CPSF3L 0 0 0 216 1 1
CAST CKB 272 0 150 354 1 1
CAST COPS4 129 0 0 230 1 1
CAST HDAC1 0 0 0 252 1 2
CAST BDH1 0 0 0 230 1 1
CAST TRPV5 0 0 295 295 1 1
CAST GPI 0 0 216 229 1 2
CAST WNT3 0 0 397 396 1 1
CAST LCTL 0 0 307 307 1 1
CAST R3HDM1 0 0 137 190 1 1
CAST KIDINS220 0 0 126 157 1 1
CAST GHR 0 0 148 171 1 1
CAST STAC3 0 0 103 239 1 1
CAST TG 0 0 119 191 1 1
CAST MYOG 0 0 208 225 1 1
CAST RPS6 0 0 134 152 1 2
CAST ATG3 0 0 95 234 1 2
CAST DNAJB1 0 0 140 158 1 2
CAST PPFIA2 213 0 0 240 1 1
CAST ENDOG 0 0 206 219 1 1
CAST PSMB5 245 0 0 297 1 1
CAST TRA2A 0 0 0 175 1 1
CAST NCOA5 0 0 90 195 1 1
CAST TTC1 0 0 0 193 1 1
CAST IL6 0 0 234 234 1 2
CAST PIK3C3 0 0 126 215 1 2
CAST SERPINB3 0 0 62 188 1 1
CAST MB 0 0 231 230 1 2
CAST SPTAN1 0 0 610 625 1 1
CAST ADAR 0 0 0 216 1 1
CAST PSMC6 0 0 0 216 1 1
CAST DGAT2 0 0 71 213 1 1
CAST LAP3 0 0 137 292 1 1
CAST KIF5B 244 0 0 322 1 1
CAST MTOR 0 0 244 243 1 2
CAST FOXO3 0 0 134 168 1 2
CAST VDAC3 0 0 72 169 1 1
CAST SRC 116 0 181 321 1 2
CAST SCD 0 0 155 170 1 1
CAST GCA 0 0 0 177 1 1
CAST CDC42 0 0 108 158 1 2
CAST PEX19 0 0 0 189 1 1
CAST SP140L 0 0 0 256 1 1
CAST TNFRSF1B 0 0 51 221 1 1
CAST ERAP1 0 0 489 518 1 1
CAST CACNA1C 0 0 207 207 1 1
CAST MC4R 0 0 134 267 1 1
CAST IBTK 0 0 108 245 1 1
CAST RASGRF2 0 0 66 211 1 1
CAST RHO 0 0 171 177 1 2
CAST WNT2B 0 0 434 434 1 1
CAST VDAC1 0 0 208 208 1 2
CAST ERBB2IP 0 0 47 195 1 1
CAST MYBPC1 0 0 94 150 1 1
CAST MFN2 0 0 166 211 1 2
CAST APP 0 0 320 337 1 2
CAST OXCT1 0 0 0 157 1 1
CAST MUSTN1 0 0 90 179 1 1
CAST USP7 0 0 0 216 1 1
CAST CTNNB1 0 0 167 185 1 2
CAST CNN1 0 0 90 219 1 1
CAST MTPAP 0 0 91 211 1 1
CAST EPB41 0 0 216 230 1 1
CAST KIAA0195 0 0 202 234 1 1
CAST WNT7A 0 0 431 431 1 1
CAST CTSL 0 0 377 377 1 2
CAST SUMO2 0 0 90 153 1 1
CAST KIAA1429 270 0 0 270 1 1
CAST EFCAB7 0 0 43 208 1 1
CAST SGCD 0 0 138 190 1 1
CAST CAPN5 0 0 518 824 1 1
CAST IQCE 0 0 45 161 1 1
CAST PSMC2 0 0 70 239 1 1
CAST IL1B 0 0 210 210 1 2
CAST TOMM20 0 0 84 155 1 2
CAST WNT7B 0 0 397 396 1 1
CAST RPL12 0 0 75 202 1 1
CAST LCOR 0 0 0 189 1 1
CAST MOS 0 0 142 156 1 1
CAST RARRES2 0 0 109 203 1 1
CAST HIF1A 0 0 112 353 1 2
CAST PPFIA4 213 0 0 240 1 1
CAST CRYGS 0 0 82 222 1 1
CAST NEFM 0 0 147 190 1 1
CAST ATF6 0 0 160 159 1 2
CAST LCORL 0 0 97 335 1 1
CAST GAPDH 0 0 297 297 1 2
CAST XIAP 0 0 226 254 1 2
CAST ENO1 0 0 181 181 1 1
CAST EPC2 0 0 113 265 1 1
CAST NMNAT1 0 0 150 272 1 1
CAST SPTB 0 0 45 204 1 1
CAST AAMP 0 0 93 188 1 1
CAST CAPN1 871 800 950 999 1 2
CAST BCL2L1 0 0 182 188 1 2
CAST AKT1 0 0 324 335 1 2
CAST UBE3A 0 0 44 410 1 1
CAST KCNIP4 0 0 391 390 1 1
CAST PPARG 0 0 134 222 1 2
CAST DYSF 0 0 63 154 1 1
CAST SMOC2 0 0 58 355 1 1
CAST SP140 0 0 0 256 1 1
CAST CPE 0 0 125 179 1 1
CAST CAPN15 0 0 390 703 1 1
CAST CASP6 0 0 188 225 1 1
CAST SUMO1 0 0 56 200 1 1
CAST HSPH1 0 0 0 204 1 1
CAST FEZ2 0 0 100 258 1 1
CAST CABIN1 0 0 108 169 1 1
CAST TGFBI 0 0 240 268 1 1
CAST WNT11 0 0 410 410 1 1
CAST IL6ST 0 0 0 445 1 1
CAST AIFM1 0 0 56 220 1 1
CAST YME1L1 0 0 67 476 1 1
CAST NCS1 0 0 157 190 1 1
CAST STC2 0 0 0 171 1 1
CAST CHCHD7 0 0 54 160 1 1
CAST FNTB 671 0 0 671 1 1
CAST GTPBP10 0 0 142 164 1 1
CAST NPEPPS 0 0 120 175 1 1
CAST FBXO32 0 0 454 499 1 2
CAST NGF 0 0 156 155 1 2
CAST WNT8A 0 0 509 509 1 1
CAST ANXA5 0 0 181 228 1 2
CAST TH 0 0 172 171 1 2
CAST MYOF 0 0 0 154 1 1
CAST CREB1 0 0 202 202 1 2
CAST ELOVL2 0 0 228 356 1 1
CAST SF1 0 0 66 439 1 1
CAST G0S2 0 0 0 152 1 1
CAST MYH3 0 0 135 174 1 1
CAST MAG 0 0 152 151 1 1
CAST NIT1 0 0 0 189 1 1
CAST TCAP 0 0 96 258 1 1
CAST GAS2 0 0 255 254 1 1
CAST PSMB1 0 0 74 255 1 1
CAST FOXO4 0 0 68 170 1 1
CAST PLGRKT 226 0 0 225 1 1
CAST EIF4EBP1 0 0 200 200 1 2
CAST PPFIA1 213 0 0 240 1 1
CAST TENC1 0 0 486 485 1 1
CAST SDR16C5 0 0 0 151 1 1
CAST CHRNE 0 0 537 537 1 1
CAST OPA1 0 0 134 157 1 2
CAST RAB3GAP1 0 0 142 165 1 1
CAST CHN2 0 0 170 356 1 1
CAST PFKM 0 0 60 166 1 1
CAST PSMA6 244 0 60 284 1 1
CAST CHAC1 0 0 72 232 1 1
CAST IGF1 0 0 261 277 1 2
CAST LNPEP 0 0 431 431 1 1
CAST EIF2B5 0 0 134 172 1 1
CAST MINK1 0 0 359 359 1 1
CAST PSMB3 245 0 0 263 1 1
CAST GDAP1 0 0 87 184 1 1
CAST CHRM5 0 0 0 163 1 1
CAST EPB41L1 245 0 0 292 1 1
CAST STC1 0 0 51 339 1 1
CAST RAPSN 0 0 123 174 1 1
CAST ACTA1 0 900 113 909 1 1
CAST ERAP2 0 0 630 630 1 1
CAST CPN1 0 0 66 231 1 1
CAST SRI 0 0 134 256 1 1
CAST FHL3 0 0 57 204 1 1
CAST HDAC3 0 0 0 596 1 2
CAST TTN 0 0 509 526 1 1
CAST FLNA 0 0 124 155 1 1
CAST PLEKHA4 270 0 0 270 1 1
CAST CCDC71L 0 0 53 216 1 1
CAST GUF1 0 0 48 169 1 1
CAST FAM174A 0 0 174 188 1 1
CAST RCAN1 0 0 82 181 1 2
CAST GH1 0 0 148 197 1 1
CAST VCL 0 0 322 336 1 1
CAST RPL39L 0 0 0 167 1 1
CAST SERPINA5 0 0 107 205 1 1
CAST RBFOX3 0 0 181 181 1 1
CAST EEF2 0 0 181 241 1 2
CAST MAP2 0 0 261 261 1 2
CAST PLAG1 0 0 147 220 1 1
CAST PIBF1 0 0 95 218 1 1
CAST MT3 0 0 91 200 1 1
CAST PSMD6 0 0 63 161 1 1
CAST TNF 0 0 254 254 1 2
CAST PTRH2 267 0 0 267 1 1
CAST CAPN3 0 0 703 906 1 1
CAST PIH1D1 240 0 0 239 1 1
CAST SMOC1 0 0 91 600 1 1
CAST WNT5A 0 0 327 327 1 2
CAST BDNF 0 0 193 193 1 2
CAST JPH2 0 0 224 240 1 1
CAST TLN1 0 900 397 938 1 1
CAST CASP2 0 0 154 153 1 1
CAST DGAT1 0 0 164 221 1 2
CAST MYC 0 0 161 161 1 2
CAST PPRC1 0 0 95 183 1 1
CAST RGPD6 0 0 171 171 1 1
CAST CAPN13 0 0 391 761 1 1
CAST STAT3 0 0 174 192 1 2
CAST HTRA1 213 0 74 255 1 1
CAST LRP2BP 0 0 164 227 1 1
CAST FBXL4 0 0 92 257 1 1
CAST WNT10B 0 0 431 431 1 1
CAST CAT 0 0 189 206 1 2
CAST MYH6 0 0 202 202 1 1
CAST RPN1 0 0 70 168 1 1
CAST PSMA3 0 0 92 244 1 1
CAST PCSK5 0 0 92 189 1 1
CAST DFFA 0 0 184 189 1 1
CAST KLF9 0 0 0 286 1 1
CAST CAPN14 0 0 387 636 1 1
CAST MLC1 0 900 0 900 1 1
CAST ATP2A2 0 0 155 199 1 1
CAST MYH2 0 0 204 204 1 1
CAST APAF1 0 0 241 254 1 2
CAST CHN1 0 0 0 206 1 1
CAST PSME3 0 0 91 157 1 1
CAST KIF18B 0 0 0 229 1 1
CAST PDCD6 0 0 73 204 1 1
CAST NFASC 0 0 118 271 1 1
CAST ADD1 0 0 75 169 1 1
CAST CHRNG 0 0 433 433 1 1
CAST WNT5B 0 0 442 442 1 1
CAST GH2 0 0 123 174 1 1
CAST PSIP1 271 0 0 271 1 1
CAST DNAJA1 0 0 125 165 1 1
CAST BCL2L2 0 0 82 180 1 1
CAST WNT9A 0 0 385 384 1 1
CAST DDIT3 0 0 181 198 1 2
CAST WNT8B 0 0 500 499 1 1
CAST HDAC2 0 0 0 252 1 1
CAST UBE2I 0 0 72 171 1 1
CAST WNT4 0 0 325 325 1 1
CAST CAPNS2 615 600 341 921 1 1
CAST VRK3 0 0 0 204 1 1
CAST NMS 0 0 101 158 1 1
CAST CAPN11 0 0 508 733 1 1
CAST PEF1 0 0 0 177 1 1
CAST NOS3 0 0 218 218 1 2
CAST FAM26E 0 0 195 195 1 1
CAST AHNAK 0 0 71 156 1 1
CAST RPS6KB1 0 0 123 181 1 2
CAST CFLAR 0 0 143 205 1 2
CAST EHD3 0 0 0 203 1 1
CAST HTT 0 0 299 351 1 2
CAST STAC 0 0 66 208 1 1
CAST SARM1 0 0 247 452 1 1
CAST PCDHB14 0 0 134 161 1 1
CAST ERC1 0 0 134 202 1 1
CAST SGK1 0 0 45 219 1 2
CAST TP53 0 0 244 243 1 2
CAST HECTD2 0 0 0 218 1 1
CAST PRPSAP1 0 0 134 193 1 1
CAST LEPROT 0 0 0 190 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0003723 Molecular Function RNA binding enables HDA
GO:0045296 Molecular Function cadherin binding enables HDA
GO:0010859 Molecular Function calcium-dependent cysteine-type endopeptidase inhibitor activity enables IBA
GO:0010859 Molecular Function calcium-dependent cysteine-type endopeptidase inhibitor activity enables IMP
GO:0004866 Molecular Function endopeptidase inhibitor activity enables TAS
GO:0005515 Molecular Function protein binding enables IPI
GO:0097340 Biological Process inhibition of cysteine-type endopeptidase activity involved_in IBA
GO:0097340 Biological Process inhibition of cysteine-type endopeptidase activity involved_in IMP
GO:2000675 Biological Process negative regulation of type B pancreatic cell apoptotic process involved_in IDA
GO:1990709 Biological Process presynaptic active zone organization involved_in TAS
GO:0005737 Cellular Component cytoplasm is_active_in IBA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005783 Cellular Component endoplasmic reticulum located_in IDA
GO:0016020 Cellular Component membrane located_in IDA
Pathways
Name DB ID
Degradation of the extracellular matrix Reactome R-HSA-1474228
Extracellular matrix organization Reactome R-HSA-1474244
Disease Reactome R-HSA-1643685
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Reactome R-HSA-8862803
Neurodegenerative Diseases Reactome R-HSA-8863678
Diseases of programmed cell death Reactome R-HSA-9645723
Defective Intrinsic Pathway for Apoptosis Reactome R-HSA-9734009
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_186779 1 miscRNA transcript variant 38 NC_000005 Reference
NR_186780 1 miscRNA transcript variant 39 NC_000005 Reference
NR_104285 2 miscRNA transcript variant 15 NC_000005 Reference
NM_001423254 1 mRNA transcript variant 31 NC_000005 Reference
NM_001423259 1 mRNA transcript variant 36 NC_000005 Reference
NM_001423253 1 mRNA transcript variant 30 NC_000005 Reference
NM_001423255 1 mRNA transcript variant 32 NC_000005 Reference
NM_001423250 1 mRNA transcript variant 27 NC_000005 Reference
NM_001423251 1 mRNA transcript variant 28 NC_000005 Reference
NM_001423256 1 mRNA transcript variant 33 NC_000005 Reference
NM_001423258 1 mRNA transcript variant 35 NC_000005 Reference
NM_001423252 1 mRNA transcript variant 29 NC_000005 Reference
NM_001423257 1 mRNA transcript variant 34 NC_000005 Reference
NM_001423260 1 mRNA transcript variant 37 NC_000005 Reference
NM_001190442 2 mRNA transcript variant 16 NC_000005 Reference
NM_001750 7 mRNA transcript variant 1 NC_000005 Reference
NM_001042441 3 mRNA transcript variant 7 NC_000005 Reference
NM_001330626 2 mRNA transcript variant 17 NC_000005 Reference
NM_001042442 3 mRNA transcript variant 8 NC_000005 Reference
NM_001042440 5 mRNA transcript variant 6 NC_000005 Reference
NM_001330627 2 mRNA transcript variant 18 NC_000005 Reference
NM_001330629 2 mRNA transcript variant 20 NC_000005 Reference
NM_001375317 1 mRNA transcript variant 26 NC_000005 Reference
NM_001330628 2 mRNA transcript variant 19 NC_000005 Reference
NM_001042443 3 mRNA transcript variant 9 NC_000005 Reference
NM_001330631 2 mRNA transcript variant 22 NC_000005 Reference
NM_001330633 2 mRNA transcript variant 24 NC_000005 Reference
NM_001330634 2 mRNA transcript variant 25 NC_000005 Reference
NM_173060 5 mRNA transcript variant 2 NC_000005 Reference
NM_001330632 2 mRNA transcript variant 23 NC_000005 Reference
NM_001042445 3 mRNA transcript variant 11 NC_000005 Reference
NM_001284213 4 mRNA transcript variant 14 NC_000005 Reference
NM_001042444 3 mRNA transcript variant 10 NC_000005 Reference
NM_001284212 4 mRNA transcript variant 13 NC_000005 Reference
NM_001042446 3 mRNA transcript variant 12 NC_000005 Reference
NM_001330630 2 mRNA transcript variant 21 NC_000005 Reference