CASP1

caspase 1
General Information
Name caspase 1
Alias
  • caspase-1
  • IL-1 beta-converting enzyme
  • IL1B-convertase
  • caspase 1, apoptosis-related cysteine peptidase
  • interleukin 1, beta, convertase
  • interleukin 1-B converting enzyme
Synonyms ICE IL1BC P45
Gene_family Caspases|Caspase recruitment domain containing
organism Homo sapiens
entrez_id 834
location 11q22.3
transcript_count 12
exon_count 12
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
      Stringdb Caspase-1; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive; Belongs to the peptidase C14A family
      nextProt Apoptosis inactive.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    CASP1 BioGRID GSR GeneID BioGRID Cross-Linking-MS (XL-MS)
    CASP1 BioGRID PYCARD GeneID BioGRID Affinity Capture-Western; Co-localization
    CASP1 BioGRID NPM1 GeneID BioGRID Cross-Linking-MS (XL-MS)
    CASP1 BioGRID NLRP3 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID RNF34 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID RUBCN GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID RAB5A GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID FLII GeneID BioGRID Affinity Capture-Western; Co-localization
    CASP1 BioGRID CEBPB GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    CASP1 BioGRID CEBPA GeneID BioGRID Proximity Label-MS
    CASP1 BioGRID NEK7 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID GSDMD GeneID BioGRID Biochemical Activity; Reconstituted Complex
    CASP1 BioGRID CFTR GeneID BioGRID PCA
    CASP1 BioGRID NLRP6 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID ESR2 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    CASP1 BioGRID ORF3a GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID ACAD10 GeneID BioGRID Co-fractionation
    CASP1 BioGRID KRT18 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID KRT8 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID FOXC1 GeneID BioGRID Affinity Capture-MS
    CASP1 BioGRID ANAPC10 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID TRIM28 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID NLRP7 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID CARD16 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    CASP1 BioGRID FMN2 GeneID BioGRID Affinity Capture-MS
    CASP1 BioGRID ARID4B GeneID BioGRID Affinity Capture-MS
    CASP1 BioGRID PLCL2 GeneID BioGRID Affinity Capture-MS
    CASP1 BioGRID KIF3A GeneID BioGRID Affinity Capture-MS
    CASP1 BioGRID PI4KB GeneID BioGRID Affinity Capture-MS
    CASP1 BioGRID KIF11 GeneID BioGRID Affinity Capture-MS
    CASP1 BioGRID GAB1 GeneID BioGRID Affinity Capture-MS
    CASP1 BioGRID DMWD GeneID BioGRID Affinity Capture-MS
    CASP1 BioGRID HUWE1 GeneID BioGRID Biochemical Activity
    CASP1 BioGRID SHARPIN GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID RNF31 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    CASP1 BioGRID RBCK1 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID IL1B GeneID BioGRID Biochemical Activity
    CASP1 BioGRID BRD4 GeneID BioGRID Affinity Capture-MS
    CASP1 BioGRID VAC14 GeneID BioGRID Two-hybrid
    CASP1 BioGRID MAPT GeneID BioGRID Biochemical Activity
    CASP1 BioGRID IFT57 GeneID BioGRID Co-localization
    CASP1 BioGRID HIP1 GeneID BioGRID Co-localization
    CASP1 BioGRID RBX1 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID KEAP1 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID CUL3 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID NFE2L2 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID SERPINB9 GeneID BioGRID Reconstituted Complex
    CASP1 BioGRID XK GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID ced-3 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID ced-4 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID BCL2L1 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID PLA2G4B GeneID BioGRID Biochemical Activity
    CASP1 BioGRID IL33 GeneID BioGRID Biochemical Activity
    CASP1 BioGRID PARP1 GeneID BioGRID Biochemical Activity
    CASP1 BioGRID BIRC3 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID TRAF2 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID TIRAP GeneID BioGRID Biochemical Activity
    CASP1 Protein CARD17P GeneID HPRD None
    CASP1 Protein CARD16 GeneID HPRD None
    CASP1 Protein CARD8 GeneID HPRD None
    CASP1 Protein PLA2G4A GeneID HPRD None
    CASP1 Protein CDK11B GeneID HPRD None
    CASP1 Protein NLRP1 GeneID HPRD None
    CASP1 Protein ATN1 GeneID HPRD None
    CASP1 Protein ATXN3 GeneID HPRD None
    CASP1 Protein PYCARD GeneID HPRD None
    CASP1 Protein NLRC4 GeneID HPRD None
    CASP1 Protein NOD1 GeneID HPRD None
    CASP1 Protein CASP14 GeneID HPRD None
    CASP1 Protein RIPK2 GeneID HPRD None
    CASP1 Protein PAK1 GeneID HPRD None
    CASP1 Protein PRKN GeneID HPRD None
    CASP1 Protein NEDD4 GeneID HPRD None
    CASP1 Protein BID GeneID HPRD None
    CASP1 Protein IL18 GeneID HPRD None
    CASP1 Protein PSEN2 GeneID HPRD None
    CASP1 Protein NFE2L2 GeneID HPRD None
    CASP1 Protein BCL2L1 GeneID HPRD None
    CASP1 Protein AR GeneID HPRD None
    CASP1 Protein BCAP31 GeneID HPRD None
    CASP1 Protein PARP1 GeneID HPRD None
    CASP1 Protein MAPT GeneID HPRD None
    CASP1 Protein LMNA GeneID HPRD None
    CASP1 Protein IL1B GeneID HPRD None
    CASP1 Protein CASP1 GeneID HPRD None
    CASP1 Protein HTT GeneID HPRD None
    CASP1 Protein EGFR GeneID HPRD None
    CASP1 Protein CDK11A GeneID HPRD None
    CASP1 Protein CAST GeneID HPRD None
    CASP1 Protein TFAP2A GeneID HPRD None
    CASP1 Protein PSEN1 GeneID HPRD None
    CASP1 BioGRID CASP14 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID IL18 GeneID BioGRID Biochemical Activity
    CASP1 BioGRID EGFR GeneID BioGRID Biochemical Activity
    CASP1 BioGRID CASP10 GeneID BioGRID Biochemical Activity
    CASP1 BioGRID CASP8 GeneID BioGRID Biochemical Activity
    CASP1 BioGRID IL37 GeneID BioGRID Biochemical Activity
    CASP1 BioGRID NOD1 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID BCAP31 GeneID BioGRID Biochemical Activity
    CASP1 BioGRID RIPK2 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID NLRC4 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID CASP1 GeneID BioGRID Affinity Capture-Western
    CASP1 BioGRID NOD2 GeneID BioGRID Affinity Capture-Western
    CASP1 None None None BIND CARD-8 interacts with Casp-1
    CASP1 None None None BIND NALP1 (NAC) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human NALP1 and CASP1 from an unspecified species.
    CASP1 None None None BIND CARD15 (Nod2) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD15 and CASP1 from an unspecified species.
    CASP1 None None None BIND CARD12 (CLAN) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD12 and CASP1 from an unspecified species.
    CASP1 Protein AR GeneID BIND Androgen Receptor interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human androgen receptor and caspase 1 from an unspecified species.
    CASP1 Protein ATXN3 GeneID BIND Ataxin-3 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human ataxin-3 and caspase 1 from an unspecified species.
    CASP1 Protein HTT GeneID BIND Huntingtin interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human huntingtin and caspase 1 from an unspecified species.
    CASP1 Protein ATN1 GeneID BIND Atrophin-1 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human atrophin-1 and caspase 1 from an unspecified species.
    CASP1 Protein PSEN1 GeneID BIND PS-1 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 1.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    CASP1 ICE1 0 0 180 191 1 1
    CASP1 XCR1 0 0 141 180 1 1
    CASP1 POTEJ 0 0 0 239 1 1
    CASP1 TRIM5 0 0 232 366 1 2
    CASP1 CX3CR1 0 0 391 439 1 1
    CASP1 NDUFAB1 0 0 108 201 1 1
    CASP1 CEBPD 0 0 96 184 1 1
    CASP1 LRMP 0 0 0 152 1 1
    CASP1 DEFB103B 0 0 210 210 1 1
    CASP1 ANXA13 0 0 123 158 1 1
    CASP1 POMC 0 0 180 179 1 1
    CASP1 HK1 0 0 134 234 1 1
    CASP1 ITPR1 0 0 188 188 1 2
    CASP1 CASP9 0 0 681 306 1 1
    CASP1 TLR7 0 0 645 705 1 1
    CASP1 MAPK9 0 0 240 256 1 2
    CASP1 OGG1 0 0 163 163 1 1
    CASP1 CD59 0 0 165 165 1 1
    CASP1 MS4A7 0 0 0 173 1 1
    CASP1 IL17A 0 0 609 632 1 1
    CASP1 NLRP5 0 0 305 310 1 1
    CASP1 ACAP2 0 0 0 163 1 1
    CASP1 ADIPOQ 0 0 323 332 1 1
    CASP1 VIM 0 0 94 150 1 1
    CASP1 ARG1 0 0 394 416 1 1
    CASP1 HLA-DQA1 0 0 143 185 1 1
    CASP1 ENO2 0 0 351 351 1 1
    CASP1 C5AR2 0 0 189 206 1 1
    CASP1 DNASE2 0 0 134 157 1 1
    CASP1 ACAP3 0 0 0 163 1 1
    CASP1 GSDMB 0 0 269 287 1 1
    CASP1 HSPA6 0 0 95 278 1 1
    CASP1 HIST2H3PS2 0 0 241 240 1 1
    CASP1 FAM72A 0 0 0 258 1 1
    CASP1 IFIH1 0 0 561 694 1 1
    CASP1 RCSD1 0 0 0 210 1 1
    CASP1 FLG 0 0 143 179 1 1
    CASP1 CTGF 0 0 213 213 1 1
    CASP1 NR3C1 0 0 218 265 1 1
    CASP1 IL2RG 0 0 134 285 1 1
    CASP1 PRF1 0 0 419 484 1 1
    CASP1 MX2 0 0 178 303 1 1
    CASP1 PTGER4 0 0 193 319 1 1
    CASP1 CISH 0 0 268 302 1 1
    CASP1 CD244 0 0 61 231 1 1
    CASP1 DPP4 0 0 212 258 1 1
    CASP1 RNF31 0 0 229 228 1 1
    CASP1 CCL4 0 0 414 507 1 1
    CASP1 RHOB 0 0 150 165 1 1
    CASP1 IL1A 270 900 739 981 1 1
    CASP1 CEACAM1 0 0 117 172 1 1
    CASP1 MAVS 0 0 605 647 1 1
    CASP1 ABCA1 0 0 263 275 1 1
    CASP1 IAPP 0 0 418 434 1 1
    CASP1 HYOU1 0 0 75 172 1 1
    CASP1 PYDC2 0 0 322 321 1 1
    CASP1 CP 0 0 127 162 1 1
    CASP1 AIM2 747 900 989 999 1 1
    CASP1 DDX58 0 0 944 952 1 1
    CASP1 C4B 0 0 231 255 1 1
    CASP1 CDK6 0 0 150 162 1 1
    CASP1 MLXIPL 0 0 155 154 1 1
    CASP1 PLG 0 0 241 250 1 1
    CASP1 TRIM21 0 0 217 290 1 1
    CASP1 BCL2L10 0 0 222 351 1 1
    CASP1 DEFB4B 0 0 161 161 1 1
    CASP1 MFGE8 0 0 216 216 1 1
    CASP1 FOLR3 0 0 0 152 1 1
    CASP1 CLEC2B 0 0 81 272 1 1
    CASP1 TROVE2 0 0 62 307 1 1
    CASP1 IL9 0 0 289 290 1 1
    CASP1 SERPINB1 0 0 109 237 1 1
    CASP1 MYLK 0 0 134 171 1 1
    CASP1 CDK11B 213 0 108 267 1 1
    CASP1 TNFRSF10A 0 0 379 402 1 1
    CASP1 TUBB3 0 0 90 203 1 1
    CASP1 PLCL2 179 0 0 193 1 1
    CASP1 IFI44L 0 0 155 264 1 1
    CASP1 LEPR 0 0 170 169 1 1
    CASP1 CD276 0 0 270 271 1 1
    CASP1 SDHA 0 0 209 209 1 1
    CASP1 KNG1 0 0 155 154 1 1
    CASP1 LRRFIP1 0 0 342 384 1 1
    CASP1 CASP8 270 800 915 916 1 2
    CASP1 ITLN1 0 0 134 166 1 1
    CASP1 AOAH 0 0 52 206 1 1
    CASP1 ITGB1 0 0 141 167 1 1
    CASP1 TNFAIP8L2 0 0 46 224 1 1
    CASP1 PHF11 0 0 0 178 1 1
    CASP1 POTED 0 0 0 155 1 1
    CASP1 LRRC3 0 0 506 524 1 1
    CASP1 HPGDS 0 0 211 239 1 1
    CASP1 TFEB 0 0 231 268 1 2
    CASP1 IL3 0 0 282 282 1 1
    CASP1 PNPLA2 0 0 180 218 1 1
    CASP1 PANX2 0 0 293 357 1 1
    CASP1 COX4I1 0 0 194 195 1 1
    CASP1 MYO1G 0 0 0 210 1 1
    CASP1 LAIR1 0 0 82 168 1 1
    CASP1 HTRA2 0 0 234 255 1 1
    CASP1 CEBPA 0 0 153 201 1 1
    CASP1 FPR2 0 0 270 324 1 1
    CASP1 THEMIS2 0 0 0 237 1 1
    CASP1 CD40 0 0 458 500 1 1
    CASP1 DNMT1 0 0 154 183 1 1
    CASP1 INS 0 0 502 505 1 1
    CASP1 GAS6 0 0 156 171 1 1
    CASP1 ACTB 0 0 664 733 1 1
    CASP1 ENSG00000258555 0 0 160 184 1 1
    CASP1 GRASP 0 0 146 195 1 1
    CASP1 ARID4B 312 0 0 313 1 1
    CASP1 FCGR2B 0 0 324 435 1 1
    CASP1 B2M 0 0 261 477 1 1
    CASP1 KEAP1 270 0 293 465 1 2
    CASP1 SIRT3 0 0 249 248 1 2
    CASP1 BRCC3 0 0 166 196 1 1
    CASP1 GLO1 0 0 134 153 1 1
    CASP1 HSPA8 0 0 194 279 1 2
    CASP1 GSR 0 0 243 248 1 1
    CASP1 EIF4G1 0 900 74 905 1 2
    CASP1 RHOA 0 900 324 930 1 1
    CASP1 PARP1 270 0 391 572 1 2
    CASP1 NKRF 0 0 123 152 1 1
    CASP1 TNFRSF14 0 0 73 355 1 1
    CASP1 BCLAF1 0 0 164 166 1 1
    CASP1 UBE2N 0 0 147 172 1 1
    CASP1 IL36A 0 0 265 403 1 1
    CASP1 CXCL12 0 0 310 309 1 1
    CASP1 TLR5 0 0 611 662 1 1
    CASP1 LRRC59 0 0 0 167 1 1
    CASP1 KLRK1 0 0 210 227 1 1
    CASP1 PLA2G1B 0 0 234 234 1 1
    CASP1 NLRP9 0 900 486 947 1 1
    CASP1 FYB 0 0 0 328 1 1
    CASP1 ESR2 0 0 697 725 1 1
    CASP1 RHOG 0 0 143 190 1 1
    CASP1 MLKL 0 0 609 684 1 1
    CASP1 UNC93B1 0 0 261 350 1 1
    CASP1 ADORA2A 0 0 261 300 1 1
    CASP1 GABARAPL1 0 0 249 270 1 2
    CASP1 TUBA1B 0 0 0 151 1 1
    CASP1 MS4A1 0 0 0 152 1 1
    CASP1 IL22 0 0 240 250 1 1
    CASP1 SIRT7 0 0 181 181 1 1
    CASP1 GPR84 0 0 56 178 1 1
    CASP1 HIP1 273 0 0 291 1 1
    CASP1 TICAM1 0 0 450 482 1 1
    CASP1 ACAP1 0 0 61 205 1 1
    CASP1 IL17RA 0 0 282 324 1 1
    CASP1 CCRL2 0 0 259 414 1 1
    CASP1 LAMP2 0 0 205 229 1 2
    CASP1 CAPN2 0 0 160 180 1 2
    CASP1 VCP 0 0 141 172 1 2
    CASP1 LCK 0 0 158 195 1 1
    CASP1 CD69 0 0 262 348 1 1
    CASP1 APOL6 0 0 45 179 1 1
    CASP1 RTP4 0 0 112 400 1 1
    CASP1 DNAJC3 0 0 270 270 1 1
    CASP1 CSTA 0 0 55 225 1 1
    CASP1 P2RY12 0 0 260 288 1 1
    CASP1 CCR5 0 0 391 526 1 1
    CASP1 IL37 270 600 560 874 1 1
    CASP1 ERN2 0 0 140 159 1 1
    CASP1 HAVCR2 0 0 233 277 1 1
    CASP1 PSMB8 0 0 184 389 1 1
    CASP1 IGFBP3 0 0 157 156 1 1
    CASP1 BIK 0 0 206 260 1 1
    CASP1 FUNDC1 0 0 168 167 1 2
    CASP1 CALR 0 0 302 337 1 1
    CASP1 ADAM8 0 0 135 241 1 1
    CASP1 CD8A 0 0 597 611 1 1
    CASP1 SIGLEC7 0 0 0 213 1 1
    CASP1 TFAM 0 0 227 226 1 1
    CASP1 IL1RAPL2 0 0 151 170 1 1
    CASP1 RIPK2 270 0 902 929 1 1
    CASP1 IL22RA2 0 0 232 231 1 1
    CASP1 TNFSF4 0 0 181 196 1 1
    CASP1 SLAMF1 0 0 95 201 1 1
    CASP1 TCIRG1 0 0 0 151 1 1
    CASP1 MMP2 0 0 321 321 1 1
    CASP1 CXCL6 0 0 123 230 1 1
    CASP1 SNCA 0 0 364 377 1 2
    CASP1 ENSG00000233917 0 0 0 155 1 1
    CASP1 CD27 0 0 181 241 1 1
    CASP1 CD74 0 0 142 294 1 1
    CASP1 KLK8 0 720 57 724 1 1
    CASP1 MVP 0 0 67 151 1 1
    CASP1 EVI2B 0 0 0 323 1 1
    CASP1 CCR3 0 0 217 273 1 1
    CASP1 GM2A 0 0 95 161 1 1
    CASP1 HSPA1A 0 0 193 294 1 1
    CASP1 GBP4 0 0 113 225 1 1
    CASP1 HLA-DRB1 0 0 123 231 1 1
    CASP1 ZFP36 0 0 108 186 1 1
    CASP1 TNFSF10 0 0 459 612 1 2
    CASP1 CAV1 0 0 168 167 1 1
    CASP1 MAP2K3 0 0 210 243 1 1
    CASP1 FFAR2 0 0 212 212 1 1
    CASP1 KIF11 376 0 49 386 1 1
    CASP1 DPP9 0 0 209 223 1 1
    CASP1 IL10RA 0 0 244 395 1 1
    CASP1 BCL2L11 0 0 391 412 1 1
    CASP1 SERPINA1 0 0 270 352 1 2
    CASP1 CCL24 0 0 154 192 1 1
    CASP1 SIGLEC1 0 0 194 306 1 1
    CASP1 PLCG1 0 0 107 207 1 1
    CASP1 ITPR3 0 0 182 181 1 1
    CASP1 TMEM173 0 0 406 487 1 1
    CASP1 TLR4 0 0 777 875 1 1
    CASP1 SMAD2 0 0 217 228 1 1
    CASP1 EMR1 0 0 96 332 1 1
    CASP1 ATG14 0 0 218 218 1 2
    CASP1 TNFRSF25 0 0 242 255 1 1
    CASP1 POTEE 0 0 0 239 1 1
    CASP1 CD14 0 0 103 354 1 1
    CASP1 NMI 0 0 74 292 1 1
    CASP1 GAPT 0 0 0 167 1 1
    CASP1 GABARAPL2 0 0 261 281 1 2
    CASP1 NOS2 0 0 408 441 1 1
    CASP1 TOM1 129 0 0 150 1 1
    CASP1 CLEC7A 0 0 561 605 1 1
    CASP1 LONRF2 0 0 0 155 1 1
    CASP1 TAB3 0 0 218 227 1 2
    CASP1 C1R 0 0 128 176 1 1
    CASP1 DNMT3A 0 0 134 188 1 1
    CASP1 BCL2L1 462 0 566 796 1 2
    CASP1 AOC3 0 0 202 202 1 1
    CASP1 CCL4L1 0 0 271 303 1 1
    CASP1 TUBB4A 0 0 95 208 1 1
    CASP1 ANXA5 0 0 556 575 1 1
    CASP1 CCNB1 0 0 166 165 1 1
    CASP1 LGALS9 0 0 261 469 1 1
    CASP1 HSPD1 0 0 206 248 1 1
    CASP1 GSDMA 0 0 651 673 1 1
    CASP1 CLEC4D 0 0 246 329 1 1
    CASP1 EPO 0 0 253 258 1 1
    CASP1 CXCL13 0 0 242 277 1 1
    CASP1 POMP 0 0 0 171 1 1
    CASP1 CA5A 0 0 181 181 1 1
    CASP1 HAVCR1 0 0 240 239 1 1
    CASP1 KCNJ11 0 0 402 402 1 1
    CASP1 HSPA1L 0 0 0 156 1 1
    CASP1 BIRC2 0 0 684 747 1 1
    CASP1 IFNG 0 0 517 616 1 2
    CASP1 TUBB1 0 0 0 185 1 1
    CASP1 PLCG2 0 0 194 291 1 1
    CASP1 CCL5 0 0 518 589 1 1
    CASP1 HCST 0 0 57 221 1 1
    CASP1 CIDEC 0 0 49 214 1 1
    CASP1 UCP2 0 0 261 277 1 1
    CASP1 RAB12 0 0 181 196 1 2
    CASP1 IL3RA 0 0 113 174 1 1
    CASP1 MPO 0 0 504 540 1 1
    CASP1 LYZ 0 0 167 319 1 1
    CASP1 ATL1 0 0 228 227 1 1
    CASP1 SCAF11 0 0 458 457 1 1
    CASP1 IL6 0 0 758 822 1 1
    CASP1 LMLN 0 0 158 157 1 1
    CASP1 TNFRSF1A 0 0 595 626 1 1
    CASP1 XK 270 0 0 300 1 1
    CASP1 SECTM1 0 0 74 297 1 1
    CASP1 TRAF4 0 0 134 176 1 1
    CASP1 PIDD1 0 0 341 439 1 1
    CASP1 PSEN2 273 0 107 337 1 1
    CASP1 FGF13 0 0 204 204 1 1
    CASP1 NOTCH1 0 0 210 223 1 1
    CASP1 ENTPD1 0 0 324 372 1 1
    CASP1 PTGS1 0 0 305 432 1 1
    CASP1 CD40LG 0 0 369 414 1 1
    CASP1 VNN1 0 0 0 152 1 1
    CASP1 APOBEC3G 0 0 150 203 1 1
    CASP1 NLRP1 486 900 989 999 1 1
    CASP1 POTEF 0 0 243 399 1 1
    CASP1 SAA1 0 0 234 242 1 1
    CASP1 GIMAP8 0 0 0 250 1 1
    CASP1 C4A 0 0 218 243 1 1
    CASP1 MAP1LC3A 0 0 282 360 1 2
    CASP1 FCGR3A 0 0 324 451 1 1
    CASP1 CDK2 0 0 183 183 1 1
    CASP1 ACTRT3 0 0 0 155 1 1
    CASP1 PLA2G4A 213 0 210 392 1 1
    CASP1 RHO 0 0 144 173 1 1
    CASP1 CXCR2 0 0 342 393 1 1
    CASP1 ERBB2IP 0 0 139 165 1 1
    CASP1 TNFRSF1B 0 0 474 553 1 1
    CASP1 MS4A4A 0 0 0 213 1 1
    CASP1 ACSL5 0 0 0 264 1 1
    CASP1 SAMSN1 0 0 0 225 1 1
    CASP1 TRPM7 0 0 181 181 1 1
    CASP1 PRKCB 0 0 161 179 1 2
    CASP1 OAS1 0 0 271 373 1 1
    CASP1 EDN1 0 0 254 261 1 1
    CASP1 HIF1A 0 0 403 410 1 2
    CASP1 TRAF5 0 0 233 251 1 1
    CASP1 SIRT5 0 0 180 179 1 1
    CASP1 HCLS1 0 0 0 322 1 1
    CASP1 GCK 0 0 74 162 1 1
    CASP1 SP1 0 0 142 155 1 1
    CASP1 IL1B 768 900 913 999 1 1
    CASP1 STAB1 0 0 83 153 1 1
    CASP1 KCNQ1 0 0 64 156 1 1
    CASP1 ADAP2 0 0 0 154 1 1
    CASP1 XRCC6 0 0 150 167 1 1
    CASP1 ERN1 0 0 406 419 1 2
    CASP1 SIVA1 0 0 112 247 1 1
    CASP1 GATA3 0 0 218 218 1 1
    CASP1 EIF4G3 0 900 0 901 1 1
    CASP1 CD55 0 0 181 181 1 1
    CASP1 MKKS 0 0 171 271 1 1
    CASP1 STAT3 0 0 506 534 1 2
    CASP1 VDAC2 0 0 182 181 1 1
    CASP1 PAK1 213 0 445 549 1 1
    CASP1 FCER2 0 0 81 173 1 1
    CASP1 PDCD6 0 0 120 167 1 1
    CASP1 CYBA 0 0 282 338 1 1
    CASP1 FGR 0 0 64 309 1 1
    CASP1 LY86 0 0 81 367 1 1
    CASP1 PLAC8 0 0 0 157 1 1
    CASP1 CSF3 0 0 391 400 1 1
    CASP1 LGALS2 0 0 0 155 1 1
    CASP1 LMNA 213 0 245 404 1 1
    CASP1 GZMH 0 0 66 163 1 1
    CASP1 ACTRT1 0 0 0 155 1 1
    CASP1 HK2 0 0 92 197 1 1
    CASP1 TRAF1 0 0 297 387 1 1
    CASP1 CAMP 0 0 455 481 1 1
    CASP1 DDIT3 0 0 297 368 1 2
    CASP1 SELPLG 0 0 138 369 1 1
    CASP1 LCP2 0 0 66 281 1 1
    CASP1 LIPN 0 0 0 157 1 1
    CASP1 CRADD 0 0 415 440 1 1
    CASP1 TUBA4A 0 0 0 151 1 1
    CASP1 IRF9 0 0 325 405 1 1
    CASP1 CFTR 0 0 233 233 1 1
    CASP1 SARM1 0 0 260 410 1 1
    CASP1 FADD 0 0 696 734 1 2
    CASP1 FFAR1 0 0 208 208 1 1
    CASP1 ESX1 0 0 451 478 1 1
    CASP1 CDK4 0 0 166 165 1 1
    CASP1 ENSG00000278522 0 0 0 155 1 1
    CASP1 PSTPIP1 0 0 509 570 1 1
    CASP1 MYD88 0 0 756 829 1 1
    CASP1 ADORA3 0 0 261 317 1 1
    CASP1 PGAM5 0 0 261 261 1 1
    CASP1 TLR1 0 0 556 795 1 1
    CASP1 NFE2L2 462 0 341 630 1 1
    CASP1 NLRP10 0 0 505 505 1 1
    CASP1 MAP2K5 0 0 86 168 1 1
    CASP1 CIDEA 0 0 136 214 1 1
    CASP1 NLRP12 0 0 654 654 1 1
    CASP1 CD80 0 0 402 455 1 1
    CASP1 FURIN 0 0 160 194 1 1
    CASP1 RBCK1 0 0 246 251 1 1
    CASP1 MFF 0 0 171 171 1 1
    CASP1 DHX58 0 0 423 528 1 1
    CASP1 OSM 0 0 141 261 1 1
    CASP1 VASP 0 0 134 169 1 1
    CASP1 MAP2K1 0 0 234 253 1 1
    CASP1 CH25H 0 0 173 217 1 1
    CASP1 PPIF 0 0 294 319 1 1
    CASP1 NOL3 0 0 217 229 1 1
    CASP1 ADAMDEC1 0 0 0 154 1 1
    CASP1 CIDEB 0 0 152 284 1 1
    CASP1 NCKAP1L 0 0 0 191 1 1
    CASP1 ALOX12 0 0 108 162 1 1
    CASP1 MPEG1 0 0 103 304 1 1
    CASP1 CHI3L1 0 0 184 213 1 1
    CASP1 NELFCD 0 0 184 183 1 1
    CASP1 ACSL1 0 0 90 163 1 1
    CASP1 APPL1 0 0 45 185 1 1
    CASP1 ANXA9 0 0 122 154 1 1
    CASP1 MAP2 0 0 139 151 1 1
    CASP1 TAB1 0 0 218 218 1 1
    CASP1 TRAF2 270 0 270 469 1 1
    CASP1 MX1 0 0 365 467 1 1
    CASP1 CD300A 0 0 0 213 1 1
    CASP1 TUBA3E 0 0 0 151 1 1
    CASP1 DHX33 0 900 378 936 1 1
    CASP1 CTDSP1 0 0 96 235 1 1
    CASP1 PLCB2 0 0 69 202 1 1
    CASP1 IL1R1 0 0 732 770 1 1
    CASP1 RARRES3 0 0 66 235 1 1
    CASP1 CLECL1 0 0 0 198 1 1
    CASP1 IFITM3 0 0 136 154 1 1
    CASP1 MYC 0 0 365 369 1 2
    CASP1 S100A7 0 0 160 159 1 1
    CASP1 IRGM 0 0 335 350 1 2
    CASP1 IL18 463 900 913 997 1 1
    CASP1 CAPN3 0 0 0 154 1 1
    CASP1 TAB2 0 0 283 291 1 1
    CASP1 SLAMF7 0 0 66 182 1 1
    CASP1 IGF1R 0 0 160 180 1 1
    CASP1 GPSM3 0 0 74 220 1 1
    CASP1 TREM1 0 0 293 420 1 1
    CASP1 LILRA1 0 0 0 288 1 1
    CASP1 PI3 0 0 145 195 1 1
    CASP1 CXCR3 0 0 284 370 1 1
    CASP1 TNFAIP2 0 0 107 232 1 1
    CASP1 IRF1 0 0 519 593 1 1
    CASP1 ATP4A 0 0 166 200 1 1
    CASP1 ELN 0 0 195 195 1 1
    CASP1 C1QA 0 0 135 256 1 1
    CASP1 SAMD9 0 0 0 239 1 1
    CASP1 CALCOCO2 0 0 294 309 1 2
    CASP1 ACTBL2 0 0 0 155 1 1
    CASP1 P2RY2 0 0 391 406 1 1
    CASP1 PDCD1 0 0 122 174 1 1
    CASP1 OPTN 0 0 243 242 1 2
    CASP1 ESR1 0 0 253 267 1 1
    CASP1 IFNB1 0 0 669 698 1 1
    CASP1 DFNA5 0 0 529 547 1 1
    CASP1 KIF3A 302 0 0 302 1 1
    CASP1 LMNB1 0 0 261 289 1 1
    CASP1 IL10RB 0 0 213 276 1 1
    CASP1 CCR9 0 0 125 160 1 1
    CASP1 FN1 0 0 391 408 1 1
    CASP1 TBP 0 0 150 162 1 1
    CASP1 C3 0 0 310 341 1 1
    CASP1 MMP13 0 0 234 257 1 1
    CASP1 PRKCA 0 0 212 212 1 1
    CASP1 MRPL44 0 0 0 151 1 1
    CASP1 ELANE 0 0 466 503 1 1
    CASP1 PKN1 0 0 219 254 1 1
    CASP1 EIF4G2 0 900 323 930 1 1
    CASP1 CD300LB 0 0 0 237 1 1
    CASP1 ULK1 0 0 288 308 1 2
    CASP1 TIMP2 0 0 150 171 1 1
    CASP1 MAP1LC3B 0 0 414 446 1 2
    CASP1 SPHK2 0 0 180 185 1 1
    CASP1 RIN3 0 0 0 152 1 1
    CASP1 SERPINB5 0 0 0 179 1 1
    CASP1 CD1E 0 0 123 173 1 1
    CASP1 SLC15A3 0 0 123 312 1 1
    CASP1 SPHK1 0 0 166 165 1 2
    CASP1 TSG101 0 0 195 200 1 2
    CASP1 GBP3 0 0 279 447 1 1
    CASP1 TIFAB 0 0 47 200 1 1
    CASP1 VAV1 0 0 156 221 1 1
    CASP1 TYRP1 0 0 190 190 1 1
    CASP1 KCNN4 0 0 84 163 1 1
    CASP1 NCF2 0 0 220 473 1 1
    CASP1 CASP16 0 0 236 283 1 1
    CASP1 IL10 0 0 681 714 1 1
    CASP1 PSMB10 0 0 112 192 1 1
    CASP1 IRAK4 0 0 502 571 1 1
    CASP1 FLT3 0 0 143 164 1 1
    CASP1 OTUD5 0 0 139 172 1 1
    CASP1 SKAP2 0 0 203 255 1 1
    CASP1 NR1H4 0 0 218 233 1 1
    CASP1 GIMAP7 0 0 66 234 1 1
    CASP1 HLA-A 0 0 124 214 1 1
    CASP1 CCL3 0 0 470 559 1 1
    CASP1 ENG 0 0 96 176 1 1
    CASP1 CTSG 0 900 506 953 1 1
    CASP1 CCL22 0 0 208 225 1 1
    CASP1 FCGR3B 0 0 325 428 1 1
    CASP1 MARCO 0 0 216 312 1 1
    CASP1 TNFRSF10C 0 0 161 222 1 1
    CASP1 IL18RAP 0 0 459 532 1 1
    CASP1 LRRFIP2 0 0 400 411 1 1
    CASP1 RORC 0 0 166 165 1 1
    CASP1 CLEC4E 0 0 421 472 1 1
    CASP1 DOCK8 0 0 95 209 1 1
    CASP1 TNFRSF9 0 0 143 166 1 1
    CASP1 FCGR2A 0 0 322 418 1 1
    CASP1 BAG1 0 0 240 239 1 2
    CASP1 CD79A 0 0 66 161 1 1
    CASP1 NGFR 0 0 181 181 1 1
    CASP1 FERMT3 0 0 52 204 1 1
    CASP1 KIT 0 0 204 204 1 1
    CASP1 ACTL7A 0 0 0 155 1 1
    CASP1 CCDC105 0 0 59 235 1 1
    CASP1 CYTIP 0 0 0 248 1 1
    CASP1 PDCD1LG2 0 0 96 233 1 1
    CASP1 CD200 0 0 163 163 1 1
    CASP1 NME8 0 0 0 192 1 1
    CASP1 NFATC1 0 0 151 192 1 1
    CASP1 BST2 0 0 233 289 1 1
    CASP1 IFNA21 0 0 208 208 1 1
    CASP1 NLRP6 0 540 901 963 1 1
    CASP1 ACTR1A 0 0 0 167 1 1
    CASP1 FPR1 0 0 282 367 1 1
    CASP1 LTA4H 0 0 166 215 1 1
    CASP1 SLC9C2 0 0 0 152 1 1
    CASP1 MCEMP1 0 0 0 151 1 1
    CASP1 GSDMC 0 0 342 393 1 1
    CASP1 CTSZ 0 0 155 296 1 1
    CASP1 PLA2G6 0 0 173 182 1 1
    CASP1 CARD16 462 800 628 946 1 1
    CASP1 CD53 0 0 45 309 1 1
    CASP1 REL 0 0 324 341 1 1
    CASP1 NLRP3 0 900 990 999 1 2
    CASP1 MSR1 0 0 195 215 1 1
    CASP1 P2RY4 0 0 158 157 1 1
    CASP1 TUBB6 0 0 63 180 1 1
    CASP1 CASP3 0 900 804 928 1 2
    CASP1 F3 0 0 258 264 1 1
    CASP1 PTGS2 0 0 523 598 1 1
    CASP1 NKG7 0 0 0 213 1 1
    CASP1 TUBB2B 0 0 0 161 1 1
    CASP1 TNFSF13B 0 0 247 375 1 1
    CASP1 CTSS 0 0 211 680 1 1
    CASP1 ACE 0 0 194 194 1 1
    CASP1 TNFRSF10B 0 0 393 416 1 1
    CASP1 IL13 0 0 517 535 1 1
    CASP1 RNASE2 0 0 61 169 1 1
    CASP1 DDX60L 0 0 88 182 1 1
    CASP1 REN 0 0 241 267 1 1
    CASP1 TRIM22 0 0 124 382 1 1
    CASP1 CYBB 0 0 506 614 1 1
    CASP1 GPR65 0 0 48 240 1 1
    CASP1 FPR3 0 0 181 279 1 1
    CASP1 GUSB 0 0 163 181 1 1
    CASP1 ARRB2 0 0 202 219 1 1
    CASP1 CXCL16 0 0 167 211 1 1
    CASP1 CDKN2A 0 0 234 273 1 2
    CASP1 GSK3B 0 0 204 263 1 2
    CASP1 MRC1 0 0 392 451 1 1
    CASP1 OR6F1 0 0 73 176 1 1
    CASP1 EIF3A 0 900 0 900 1 1
    CASP1 EPSTI1 0 0 0 202 1 1
    CASP1 S100B 0 0 233 232 1 1
    CASP1 IL1RAP 0 0 524 543 1 1
    CASP1 NRROS 0 0 0 178 1 1
    CASP1 CIITA 0 0 468 523 1 1
    CASP1 ECSIT 0 0 155 154 1 1
    CASP1 PDIA4 0 0 61 183 1 1
    CASP1 NOD2 486 0 964 990 1 1
    CASP1 PIK3CD 0 0 66 162 1 1
    CASP1 IL13RA1 0 0 143 184 1 1
    CASP1 CEBPB 270 0 241 461 1 1
    CASP1 SMPD1 0 0 271 306 1 1
    CASP1 ATG16L1 270 0 519 649 1 2
    CASP1 LTBR 0 0 170 195 1 1
    CASP1 RIPK1 0 0 609 639 1 1
    CASP1 TUBA8 0 0 0 151 1 1
    CASP1 FASLG 0 0 530 541 1 1
    CASP1 SOCS3 0 0 325 372 1 1
    CASP1 RHOD 0 0 134 150 1 1
    CASP1 IGSF6 0 0 54 191 1 1
    CASP1 MNDA 0 0 369 598 1 1
    CASP1 AQP4 0 0 157 156 1 1
    CASP1 CLDN2 0 0 148 159 1 1
    CASP1 STAT5A 0 0 234 321 1 1
    CASP1 BIRC7 0 0 123 291 1 1
    CASP1 XAF1 0 0 174 298 1 1
    CASP1 RNASE6 0 0 0 298 1 1
    CASP1 TNIP1 0 0 94 162 1 1
    CASP1 VIPR1 0 0 156 155 1 1
    CASP1 SLC2A9 0 0 46 179 1 1
    CASP1 PKN2 0 0 261 271 1 1
    CASP1 ITGB2 0 0 234 479 1 1
    CASP1 KRAS 0 0 150 223 1 1
    CASP1 CD3E 0 0 119 209 1 1
    CASP1 HLA-B 0 0 101 325 1 1
    CASP1 JMJD6 0 0 140 159 1 1
    CASP1 GPBAR1 0 0 210 277 1 1
    CASP1 C18orf8 0 0 159 158 1 1
    CASP1 MAPT 270 0 193 385 1 2
    CASP1 BECN1 0 0 522 557 1 2
    CASP1 HLA-DPA1 0 0 90 265 1 1
    CASP1 THBS1 0 0 193 193 1 1
    CASP1 IL2 0 0 504 517 1 1
    CASP1 TLR6 0 0 504 634 1 1
    CASP1 OLR1 0 0 232 269 1 1
    CASP1 ANXA1 0 0 249 319 1 1
    CASP1 VSIG4 0 0 163 259 1 1
    CASP1 LRP1 0 0 209 213 1 1
    CASP1 DUSP1 0 0 242 271 1 1
    CASP1 MAPK11 0 0 127 173 1 1
    CASP1 ATXN3 199 0 123 267 1 1
    CASP1 PTGER3 0 0 150 163 1 1
    CASP1 HSH2D 0 0 292 334 1 1
    CASP1 WARS 0 0 103 167 1 1
    CASP1 IL18R1 0 0 377 480 1 1
    CASP1 POTEH 0 0 0 155 1 1
    CASP1 POTEC 0 0 0 155 1 1
    CASP1 BIN2 0 0 43 175 1 1
    CASP1 CAPN9 0 0 0 152 1 1
    CASP1 CD81 0 0 210 248 1 1
    CASP1 IFNA17 0 0 188 188 1 1
    CASP1 CARD11 0 0 181 229 1 1
    CASP1 HLA-DRA 0 0 118 294 1 1
    CASP1 UBR2 0 0 134 165 1 1
    CASP1 XIAP 0 0 628 712 1 1
    CASP1 GMFG 0 0 0 191 1 1
    CASP1 SERPINB6 0 720 75 748 1 1
    CASP1 CFH 0 0 194 242 1 1
    CASP1 IFNLR1 0 0 143 159 1 1
    CASP1 OR2G2 0 0 113 178 1 1
    CASP1 ATF6 0 0 335 396 1 2
    CASP1 IKBKB 0 0 500 558 1 1
    CASP1 LETM1 0 0 413 412 1 1
    CASP1 ALOX5AP 0 0 142 346 1 1
    CASP1 KLF4 0 0 125 170 1 1
    CASP1 PANX1 0 0 796 841 1 1
    CASP1 CD4 0 0 635 704 1 1
    CASP1 ATF4 0 0 181 232 1 2
    CASP1 TUBA3C 0 0 0 151 1 1
    CASP1 CARD8 213 900 959 996 1 1
    CASP1 IL12RB1 0 0 202 225 1 1
    CASP1 LY96 0 0 469 641 1 1
    CASP1 ACTL8 0 0 0 155 1 1
    CASP1 SP140 0 0 60 217 1 1
    CASP1 CD48 0 0 91 331 1 1
    CASP1 GBP2 0 0 327 700 1 1
    CASP1 OR13G1 0 0 74 177 1 1
    CASP1 AKT1 0 0 556 586 1 2
    CASP1 CYTH4 0 0 0 180 1 1
    CASP1 TGFB2 0 0 155 154 1 1
    CASP1 CAPN1 0 0 218 252 1 2
    CASP1 PPARG 0 0 423 457 1 1
    CASP1 NLRP7 0 0 848 899 1 1
    CASP1 CTSC 0 0 245 330 1 1
    CASP1 TAP1 0 0 0 170 1 1
    CASP1 BBC3 0 0 173 173 1 1
    CASP1 CCL3L3 0 0 66 187 1 1
    CASP1 ARG2 0 0 240 239 1 1
    CASP1 ERBB2 0 0 160 176 1 2
    CASP1 IRF3 0 0 630 630 1 1
    CASP1 TLR9 0 0 668 727 1 1
    CASP1 GZMK 0 0 117 182 1 1
    CASP1 CFP 0 0 102 166 1 1
    CASP1 CD1D 0 0 252 323 1 1
    CASP1 FUCA1 0 0 91 154 1 1
    CASP1 PYCARD 973 900 989 999 1 1
    CASP1 MAP3K1 0 0 180 179 1 1
    CASP1 GPRC6A 0 0 171 171 1 1
    CASP1 BIRC8 0 0 321 474 1 1
    CASP1 MALT1 0 0 391 404 1 1
    CASP1 CXCL10 0 0 518 637 1 1
    CASP1 GAS2 0 0 77 160 1 1
    CASP1 IL24 0 0 96 194 1 2
    CASP1 BIRC5 0 0 170 314 1 2
    CASP1 SIRT4 0 0 178 177 1 1
    CASP1 IL11 0 0 202 278 1 1
    CASP1 STAT6 0 0 336 403 1 1
    CASP1 UBE2C 0 0 0 152 1 1
    CASP1 TUBB8B 0 0 0 161 1 1
    CASP1 TNFSF12 0 0 203 262 1 1
    CASP1 EIF2AK3 0 0 359 359 1 2
    CASP1 TUBB8 0 0 0 161 1 1
    CASP1 RABGEF1 0 0 66 251 1 1
    CASP1 PLSCR1 0 0 101 302 1 1
    CASP1 LGALS3 0 0 324 401 1 1
    CASP1 TUBA1C 0 0 0 151 1 1
    CASP1 HSPA12A 0 0 0 152 1 1
    CASP1 DOCK2 0 0 183 366 1 1
    CASP1 SRC 0 0 375 393 1 1
    CASP1 SAMD9L 0 0 86 582 1 1
    CASP1 ACTL6A 0 0 0 156 1 1
    CASP1 HP 0 0 164 182 1 1
    CASP1 IL36B 0 0 216 378 1 1
    CASP1 SHISA5 0 0 124 150 1 1
    CASP1 MCU 0 0 140 150 1 1
    CASP1 EEA1 0 0 161 161 1 1
    CASP1 CD47 0 0 230 246 1 1
    CASP1 SPTAN1 0 0 210 239 1 1
    CASP1 DHFRL1 0 0 0 151 1 1
    CASP1 CD2 0 0 123 291 1 1
    CASP1 CDKN1B 0 0 144 159 1 2
    CASP1 IFIT1 0 0 294 351 1 1
    CASP1 RBX1 270 0 288 468 1 1
    CASP1 LGALS9C 0 0 0 179 1 1
    CASP1 HCAR3 0 0 0 184 1 1
    CASP1 DPP8 0 0 228 241 1 1
    CASP1 BNIP3L 0 0 233 329 1 2
    CASP1 ADORA2B 0 0 261 272 1 1
    CASP1 C1QB 0 0 176 254 1 1
    CASP1 PF4 0 0 181 223 1 1
    CASP1 EIF2S1 0 0 235 240 1 2
    CASP1 MMP12 0 0 231 275 1 1
    CASP1 ANPEP 0 0 66 231 1 1
    CASP1 JAK1 0 0 299 339 1 1
    CASP1 TOMM20 0 0 230 247 1 1
    CASP1 P2RX1 0 0 298 409 1 1
    CASP1 A26B3 0 0 0 155 1 1
    CASP1 STX17 0 0 150 162 1 2
    CASP1 TICAM2 0 0 164 262 1 1
    CASP1 TCHP 0 0 232 231 1 1
    CASP1 PPBP 0 0 139 258 1 1
    CASP1 RHOH 0 0 150 184 1 1
    CASP1 NRG1 0 0 57 201 1 2
    CASP1 HMOX1 0 0 469 488 1 2
    CASP1 TRIM14 0 0 134 170 1 1
    CASP1 IL32 0 0 390 433 1 1
    CASP1 CCL1 0 0 184 183 1 1
    CASP1 CAT 0 0 457 486 1 1
    CASP1 ARHGAP25 0 0 0 163 1 1
    CASP1 SFTPD 0 0 143 158 1 1
    CASP1 HGF 0 0 203 262 1 1
    CASP1 CAST 213 0 235 400 1 1
    CASP1 HRK 0 0 259 258 1 1
    CASP1 CANX 0 0 170 169 1 2
    CASP1 ATG2A 0 0 62 153 1 2
    CASP1 BAK1 0 0 263 391 1 2
    CASP1 AVEN 0 0 103 159 1 1
    CASP1 BCL2 0 0 176 332 1 2
    CASP1 IFI44 0 0 180 356 1 1
    CASP1 RNASEL 0 0 299 404 1 1
    CASP1 HPRT1 0 0 310 309 1 1
    CASP1 CTLA4 0 0 371 394 1 1
    CASP1 CCL19 0 0 194 229 1 1
    CASP1 HLA-E 0 0 90 253 1 1
    CASP1 FLT3LG 0 0 146 157 1 1
    CASP1 DPYD 0 0 47 184 1 1
    CASP1 CD274 0 0 247 438 1 1
    CASP1 SREBF2 0 0 218 222 1 1
    CASP1 CSF2RB 0 0 142 449 1 1
    CASP1 HK3 0 0 0 306 1 1
    CASP1 BCL2L2 0 0 279 398 1 1
    CASP1 DDX60 0 0 168 331 1 1
    CASP1 HSPA9 0 0 100 192 1 1
    CASP1 SGK1 0 0 136 182 1 1
    CASP1 IRS1 0 0 284 296 1 1
    CASP1 SNX20 0 0 0 162 1 1
    CASP1 DRD1 0 0 148 161 1 1
    CASP1 LOX 0 0 181 181 1 1
    CASP1 PLSCR2 0 0 0 156 1 1
    CASP1 GNLY 0 0 117 169 1 1
    CASP1 P2RY10 0 0 45 165 1 1
    CASP1 NLRP2 0 0 794 862 1 1
    CASP1 AHR 0 0 265 291 1 1
    CASP1 SERPINE1 0 0 261 266 1 1
    CASP1 TNFAIP8 0 0 120 176 1 1
    CASP1 RPS6KB1 0 0 241 259 1 2
    CASP1 ADRB2 0 0 121 167 1 1
    CASP1 FCGR1A 0 0 269 394 1 1
    CASP1 AGTR1 0 0 143 156 1 1
    CASP1 MERTK 0 0 234 260 1 1
    CASP1 EVI2A 0 0 0 220 1 1
    CASP1 IRF7 0 0 517 576 1 1
    CASP1 ITIH4 0 0 245 267 1 1
    CASP1 DDX53 0 0 123 150 1 1
    CASP1 UVRAG 0 0 203 203 1 2
    CASP1 RETN 0 0 193 265 1 1
    CASP1 CDH5 0 0 141 156 1 1
    CASP1 ATF3 0 0 261 277 1 1
    CASP1 MS4A14 0 0 53 223 1 1
    CASP1 FFAR3 0 0 122 165 1 1
    CASP1 IFI35 0 0 108 229 1 1
    CASP1 IFNL1 0 0 154 153 1 1
    CASP1 IFI16 270 0 936 967 1 1
    CASP1 MMP8 0 0 184 256 1 1
    CASP1 TXNIP 0 0 711 762 1 1
    CASP1 BMF 0 0 158 194 1 1
    CASP1 CD9 0 0 144 155 1 1
    CASP1 RAB7A 0 0 255 261 1 2
    CASP1 S100A9 0 0 181 385 1 1
    CASP1 DRAM1 0 0 124 182 1 2
    CASP1 NFKB2 0 0 285 362 1 1
    CASP1 ATG4B 0 0 235 262 1 2
    CASP1 ATP12A 0 0 167 201 1 1
    CASP1 TNFAIP3 0 0 315 488 1 1
    CASP1 GCG 0 0 194 194 1 1
    CASP1 IL5 0 0 456 467 1 1
    CASP1 IL1R2 0 900 469 953 1 1
    CASP1 CD70 0 0 150 165 1 1
    CASP1 TFRC 0 0 184 183 1 1
    CASP1 TFAP2A 213 0 0 213 1 1
    CASP1 PPP1R15A 0 0 184 213 1 2
    CASP1 POTEB2 0 0 0 155 1 1
    CASP1 RNF135 0 0 177 177 1 1
    CASP1 RBFOX3 0 0 292 322 1 1
    CASP1 CLEC10A 0 0 134 289 1 1
    CASP1 WIPI2 0 0 87 182 1 2
    CASP1 MS4A6A 0 0 45 235 1 1
    CASP1 FIS1 0 0 157 176 1 2
    CASP1 NAIP 0 540 802 925 1 1
    CASP1 LPIN2 0 0 182 181 1 1
    CASP1 VDR 0 0 158 204 1 1
    CASP1 IL1RN 0 0 559 655 1 1
    CASP1 MMP3 0 0 324 363 1 1
    CASP1 NT5E 0 0 230 229 1 1
    CASP1 C22orf29 0 0 262 262 1 1
    CASP1 TNF 0 0 759 838 1 1
    CASP1 NBR1 0 0 205 218 1 2
    CASP1 IFITM1 0 0 150 200 1 1
    CASP1 GATA4 0 0 164 164 1 2
    CASP1 IRF2 0 0 282 336 1 1
    CASP1 HSPA4 0 0 369 447 1 1
    CASP1 CTSH 0 0 134 226 1 1
    CASP1 PYDC1 0 0 465 465 1 1
    CASP1 PIK3R1 117 0 91 163 1 1
    CASP1 IGSF3 0 0 56 158 1 1
    CASP1 DICER1 0 0 233 370 1 1
    CASP1 CCR2 0 0 456 565 1 2
    CASP1 ISG20 0 0 134 184 1 1
    CASP1 PDE6B 0 0 275 301 1 1
    CASP1 FAM188A 0 0 494 493 1 1
    CASP1 CYP2E1 0 0 217 217 1 1
    CASP1 CLEC12A 0 0 96 274 1 1
    CASP1 HSPB3 0 0 539 548 1 1
    CASP1 HSP90B1 0 0 232 279 1 1
    CASP1 CXCL9 0 0 374 458 1 1
    CASP1 LPL 0 0 139 162 1 1
    CASP1 CETP 0 0 55 152 1 1
    CASP1 PPARA 0 0 321 334 1 1
    CASP1 TRAF6 0 0 558 585 1 2
    CASP1 SLC1A2 0 0 180 198 1 1
    CASP1 PYHIN1 0 0 405 476 1 1
    CASP1 IL18BP 0 0 600 632 1 1
    CASP1 RAC3 0 0 125 160 1 1
    CASP1 DHX36 0 0 269 278 1 1
    CASP1 APPL2 0 0 0 182 1 1
    CASP1 CXCL11 0 0 280 322 1 1
    CASP1 CYCS 0 0 635 665 1 1
    CASP1 DUSP12 0 0 155 172 1 1
    CASP1 GADD45B 0 0 164 212 1 1
    CASP1 PRTN3 0 0 518 551 1 1
    CASP1 EGF 0 0 294 295 1 1
    CASP1 PLAU 0 0 146 152 1 1
    CASP1 PCSK1 0 0 391 415 1 1
    CASP1 RASAL3 0 0 0 185 1 1
    CASP1 MAPK8 0 0 408 420 1 2
    CASP1 SERPING1 0 0 150 168 1 1
    CASP1 MAP2K4 0 0 184 216 1 1
    CASP1 SLA 0 0 0 169 1 1
    CASP1 LILRB2 0 0 67 342 1 1
    CASP1 CDK11A 213 0 108 267 1 1
    CASP1 ARHGDIB 0 900 47 930 1 1
    CASP1 IL1F10 0 0 450 517 1 1
    CASP1 GPX4 0 0 217 217 1 1
    CASP1 VR1 0 0 182 181 1 1
    CASP1 BATF3 0 0 112 154 1 1
    CASP1 DIABLO 0 0 451 456 1 1
    CASP1 P2RX7 0 0 689 803 1 1
    CASP1 PRNP 0 0 151 168 1 1
    CASP1 CCR1 0 0 256 452 1 1
    CASP1 FAM26F 0 0 60 229 1 1
    CASP1 MAF 0 0 147 165 1 1
    CASP1 GBP1 0 0 257 676 1 1
    CASP1 SRGN 0 0 74 551 1 1
    CASP1 ACTR1B 0 0 0 155 1 1
    CASP1 CRYGC 0 0 261 261 1 1
    CASP1 SIGLEC9 0 0 54 223 1 1
    CASP1 TRADD 0 0 468 526 1 1
    CASP1 AGER 0 0 458 474 1 1
    CASP1 SLC22A12 0 0 165 165 1 1
    CASP1 ACTC1 0 0 51 195 1 1
    CASP1 SIRT6 0 0 181 181 1 1
    CASP1 DDX41 0 0 390 398 1 1
    CASP1 HSPA14 0 0 55 152 1 1
    CASP1 BCL2L13 0 0 240 239 1 1
    CASP1 NCF4 0 0 161 370 1 1
    CASP1 CDH1 0 0 284 284 1 1
    CASP1 MB21D1 0 0 595 625 1 1
    CASP1 CD33 0 0 181 238 1 1
    CASP1 PRKCZ 0 0 150 169 1 1
    CASP1 EP300 0 0 183 183 1 1
    CASP1 SIRPA 0 0 166 215 1 1
    CASP1 CDK5 0 0 164 170 1 2
    CASP1 LGALS8 0 0 218 247 1 1
    CASP1 IL27 0 0 103 156 1 1
    CASP1 SCARB1 0 0 150 203 1 1
    CASP1 IL4 0 0 565 592 1 1
    CASP1 SMAD3 117 650 357 817 1 1
    CASP1 IL17F 0 0 281 282 1 1
    CASP1 ANXA8 0 0 294 294 1 1
    CASP1 BIRC3 270 0 408 726 1 1
    CASP1 PTBP2 0 900 0 900 1 1
    CASP1 ROCK1 0 0 165 184 1 1
    CASP1 IDO1 0 0 247 298 1 1
    CASP1 IL16 0 0 182 277 1 1
    CASP1 IFI6 0 0 150 205 1 1
    CASP1 CARD17 823 800 487 965 1 1
    CASP1 EIF4A1 0 900 69 904 1 1
    CASP1 CCL2 0 0 618 655 1 2
    CASP1 NCMAP 0 0 450 460 1 1
    CASP1 ALB 0 0 520 569 1 1
    CASP1 CD68 0 0 467 565 1 1
    CASP1 ANXA3 0 0 139 170 1 1
    CASP1 CASP7 0 0 754 377 1 1
    CASP1 ELAVL1 0 0 143 166 1 1
    CASP1 TYROBP 0 0 216 469 1 1
    CASP1 MBL2 0 0 235 235 1 1
    CASP1 IL21 0 0 0 461 1 1
    CASP1 BCL3 0 0 0 215 1 1
    CASP1 LTB 0 0 123 236 1 1
    CASP1 HSP90AA1 0 0 493 512 1 2
    CASP1 PSEN1 213 0 391 518 1 2
    CASP1 TP73 0 900 150 922 1 2
    CASP1 CRP 0 0 464 485 1 1
    CASP1 P2RX2 0 0 195 201 1 1
    CASP1 SP100 0 0 112 246 1 1
    CASP1 CLEC2D 0 0 68 169 1 1
    CASP1 IFIT5 0 0 95 180 1 1
    CASP1 EPRS 0 0 134 151 1 1
    CASP1 SELL 0 0 284 407 1 1
    CASP1 GBP7 0 0 289 321 1 1
    CASP1 FGF1 0 0 112 177 1 1
    CASP1 C1S 0 0 155 200 1 1
    CASP1 NLRX1 0 0 543 566 1 1
    CASP1 SELP 0 0 260 333 1 1
    CASP1 ATG13 0 0 195 226 1 2
    CASP1 GIMAP4 0 0 49 250 1 1
    CASP1 JUNB 0 0 81 167 1 1
    CASP1 ANXA4 0 0 125 177 1 1
    CASP1 SQSTM1 0 0 422 442 1 2
    CASP1 BNIP3 0 0 269 340 1 2
    CASP1 MMP9 0 0 466 531 1 1
    CASP1 RND1 0 0 113 152 1 1
    CASP1 MAPK3 0 0 457 490 1 2
    CASP1 ABCG1 0 0 212 229 1 1
    CASP1 THY1 0 0 135 150 1 1
    CASP1 HLA-DMB 0 0 54 219 1 1
    CASP1 BID 213 800 334 888 1 1
    CASP1 CD1C 0 0 207 298 1 1
    CASP1 GSN 0 0 209 214 1 1
    CASP1 IFNAR2 0 0 252 292 1 1
    CASP1 FGL2 0 0 66 280 1 1
    CASP1 AR 213 0 201 359 1 1
    CASP1 CSF2RA 0 0 97 162 1 1
    CASP1 SPP1 0 0 288 288 1 1
    CASP1 CDKN1A 0 0 261 276 1 2
    CASP1 ATG9A 0 0 115 179 1 2
    CASP1 BAX 0 0 300 416 1 2
    CASP1 GPR29 0 0 241 270 1 1
    CASP1 F10 0 0 154 153 1 1
    CASP1 TIMP1 0 0 290 301 1 1
    CASP1 CCL18 0 0 151 218 1 1
    CASP1 PTPRC 0 0 458 610 1 1
    CASP1 TRIM31 0 0 166 166 1 1
    CASP1 CXCR1 0 0 208 292 1 1
    CASP1 ITGAV 0 0 345 345 1 1
    CASP1 BCL10 0 0 465 477 1 1
    CASP1 ICAM1 0 0 505 579 1 1
    CASP1 RALB 0 0 142 179 1 1
    CASP1 PTGER2 0 0 69 196 1 1
    CASP1 ASAP3 0 0 0 163 1 1
    CASP1 FYN 0 0 158 177 1 1
    CASP1 NLRP8 0 0 486 485 1 1
    CASP1 P2RX5 0 0 166 181 1 1
    CASP1 GTF2F1 0 0 0 161 1 1
    CASP1 NFKBIE 0 0 134 240 1 1
    CASP1 CLEC6A 0 0 390 432 1 1
    CASP1 PQBP1 0 0 134 270 1 1
    CASP1 OR14A16 0 0 90 172 1 1
    CASP1 PARP14 0 0 96 318 1 1
    CASP1 TBL1X 0 0 134 154 1 1
    CASP1 SOD1 0 0 401 439 1 1
    CASP1 LTA 0 0 259 421 1 1
    CASP1 IL7R 0 0 272 360 1 1
    CASP1 IL36RN 0 0 409 501 1 1
    CASP1 ACTR3C 0 0 0 154 1 1
    CASP1 EIF2AK2 0 0 262 312 1 2
    CASP1 LSP1 0 0 0 226 1 1
    CASP1 RAB27A 0 0 136 176 1 1
    CASP1 TMEM106A 0 0 46 187 1 1
    CASP1 MFN1 0 0 232 261 1 1
    CASP1 P2RY1 0 0 205 238 1 1
    CASP1 UCHL1 0 0 94 157 1 1
    CASP1 IRS2 0 0 142 157 1 1
    CASP1 KCNK6 0 0 139 177 1 1
    CASP1 TREM2 0 0 252 296 1 1
    CASP1 TRIM38 0 0 92 182 1 1
    CASP1 DNTT 0 0 465 468 1 1
    CASP1 GORASP2 0 0 444 454 1 1
    CASP1 NOS1 0 0 184 183 1 1
    CASP1 HIC1 0 0 0 184 1 1
    CASP1 AIF1 0 0 505 569 1 1
    CASP1 PIK3CG 0 0 108 296 1 1
    CASP1 JAK3 0 0 172 264 1 1
    CASP1 PADI4 0 0 155 173 1 1
    CASP1 BOK 0 0 157 297 1 2
    CASP1 DAPP1 0 0 0 165 1 1
    CASP1 GZMA 0 0 324 426 1 1
    CASP1 ACTR3 0 0 46 158 1 1
    CASP1 SERPINB2 0 0 214 338 1 1
    CASP1 ITGAL 0 0 194 292 1 1
    CASP1 APIP 0 0 246 245 1 1
    CASP1 ENSG00000173366 0 0 664 713 1 1
    CASP1 NLRP13 0 0 605 605 1 1
    CASP1 S1PR4 0 0 0 212 1 1
    CASP1 DHX15 0 0 82 190 1 1
    CASP1 TAPBP 0 0 95 167 1 1
    CASP1 JUN 0 0 519 547 1 1
    CASP1 SKA3 0 0 0 173 1 1
    CASP1 TYK2 0 0 241 273 1 1
    CASP1 DAPK1 0 0 166 176 1 2
    CASP1 ENTPD2 0 0 164 163 1 1
    CASP1 ENO1 0 0 178 177 1 1
    CASP1 GAPDH 0 0 610 634 1 2
    CASP1 CD83 0 0 248 288 1 1
    CASP1 OAS2 0 0 183 340 1 1
    CASP1 CENPV 0 0 284 284 1 1
    CASP1 ABL1 0 0 134 160 1 1
    CASP1 PTBP1 0 900 0 900 1 1
    CASP1 CD1A 0 0 125 167 1 1
    CASP1 CX3CL1 0 0 340 355 1 1
    CASP1 MAP2K7 0 0 242 261 1 1
    CASP1 TRIM25 0 0 306 341 1 1
    CASP1 TLR10 0 0 325 502 1 1
    CASP1 ZAP70 0 0 123 208 1 1
    CASP1 STAT4 0 0 241 352 1 1
    CASP1 CASP6 0 0 681 305 1 1
    CASP1 ITGA4 0 0 113 199 1 1
    CASP1 EVPL 0 0 82 165 1 1
    CASP1 NFKB1 0 0 338 451 1 1
    CASP1 RELA 0 0 391 437 1 1
    CASP1 SIRT2 0 0 243 242 1 2
    CASP1 IL4R 0 0 213 276 1 1
    CASP1 ODF3B 0 0 0 175 1 1
    CASP1 IQGAP1 0 0 533 543 1 1
    CASP1 C5AR1 0 0 294 347 1 1
    CASP1 KLHDC7B 0 0 0 164 1 1
    CASP1 HCAR2 0 0 242 354 1 1
    CASP1 ARHGAP30 0 0 45 223 1 1
    CASP1 CCL13 0 0 122 166 1 1
    CASP1 ESRRA 0 0 82 223 1 1
    CASP1 PANX3 0 0 267 351 1 1
    CASP1 HLA-DPB1 0 0 90 182 1 1
    CASP1 CREBBP 0 0 155 154 1 1
    CASP1 GZMM 0 0 141 183 1 1
    CASP1 RAPGEF3 0 0 138 230 1 1
    CASP1 DHX9 0 0 195 229 1 1
    CASP1 CREB1 0 0 314 319 1 1
    CASP1 GSDMD 800 800 953 998 1 1
    CASP1 DOK2 0 0 0 151 1 1
    CASP1 NLRC3 0 0 469 530 1 1
    CASP1 ETS2 0 0 134 171 1 1
    CASP1 PIK3C3 0 0 293 304 1 2
    CASP1 CTRL 0 0 230 229 1 1
    CASP1 MOG 0 0 280 280 1 1
    CASP1 STAT1 0 0 561 653 1 1
    CASP1 ENDOG 0 0 282 301 1 1
    CASP1 BCL2L2-PABPN1 0 0 241 376 1 1
    CASP1 DEFB1 0 0 182 199 1 1
    CASP1 GZMB 0 0 467 529 1 1
    CASP1 NPHS1 0 0 181 181 1 1
    CASP1 PLEK 0 0 91 382 1 1
    CASP1 OCLN 0 0 296 308 1 1
    CASP1 CXCR4 0 0 322 371 1 2
    CASP1 MMP1 0 0 234 266 1 1
    CASP1 MTOR 0 0 390 408 1 2
    CASP1 GIMAP6 0 0 0 214 1 1
    CASP1 ANXA11 0 0 142 185 1 1
    CASP1 CD163 0 0 315 395 1 1
    CASP1 ADAR 0 0 137 171 1 1
    CASP1 CTNNB1 0 0 321 333 1 1
    CASP1 HRAS 0 0 204 239 1 1
    CASP1 GIMAP5 0 0 43 231 1 1
    CASP1 MFN2 0 0 290 317 1 2
    CASP1 APP 45 0 413 427 1 1
    CASP1 EGR1 0 0 180 192 1 1
    CASP1 TRPV1 0 0 182 181 1 1
    CASP1 C3AR1 0 0 261 411 1 1
    CASP1 IKBKE 0 0 240 386 1 1
    CASP1 ERAP1 0 0 108 177 1 1
    CASP1 POTEM 0 0 0 155 1 1
    CASP1 P2RY14 0 0 142 191 1 1
    CASP1 NEDD4 213 0 108 280 1 2
    CASP1 NR1H3 0 0 113 172 1 1
    CASP1 RAB5A 0 0 231 249 1 2
    CASP1 PLD4 0 0 0 172 1 1
    CASP1 ENSG00000268500 0 0 108 276 1 1
    CASP1 CXCL8 0 0 662 722 1 1
    CASP1 FOLR2 0 0 0 155 1 1
    CASP1 ASAP1 0 0 0 163 1 1
    CASP1 CTSL 0 0 373 398 1 1
    CASP1 IL6R 0 0 235 291 1 1
    CASP1 FMN2 288 0 0 288 1 1
    CASP1 MUC5AC 0 0 183 197 1 1
    CASP1 RAB8A 0 0 113 152 1 2
    CASP1 PTPN22 0 0 165 253 1 1
    CASP1 POTEG 0 0 0 155 1 1
    CASP1 GDNF 0 0 181 181 1 1
    CASP1 IFNA2 0 0 211 211 1 1
    CASP1 HBEGF 0 0 162 173 1 1
    CASP1 CD300C 0 0 170 319 1 1
    CASP1 NLRC5 0 0 558 678 1 1
    CASP1 JAK2 0 0 323 395 1 1
    CASP1 HDAC6 0 0 157 156 1 2
    CASP1 APAF1 0 0 634 778 1 1
    CASP1 ACTL7B 0 0 0 155 1 1
    CASP1 CLU 0 0 166 165 1 2
    CASP1 P2RX4 0 0 470 513 1 1
    CASP1 PSTPIP2 0 0 323 359 1 1
    CASP1 IRAK1 0 0 519 570 1 1
    CASP1 CARD9 0 0 518 561 1 1
    CASP1 MAP3K7 0 0 261 277 1 1
    CASP1 NLRP4 0 800 505 898 1 1
    CASP1 APBB1IP 0 0 0 231 1 1
    CASP1 EDA 0 0 0 212 1 1
    CASP1 MAP1A 0 0 184 190 1 1
    CASP1 ZBP1 0 0 391 458 1 1
    CASP1 TNFRSF11B 0 0 195 195 1 1
    CASP1 CD200R1 0 0 210 274 1 1
    CASP1 NFKBIZ 0 0 139 254 1 1
    CASP1 LCN2 0 0 335 381 1 1
    CASP1 TP53 385 900 556 971 1 2
    CASP1 MDM2 0 0 240 256 1 1
    CASP1 ALOX15 0 0 170 188 1 1
    CASP1 TRIM16 0 0 381 381 1 2
    CASP1 TGM2 0 0 146 176 1 1
    CASP1 LAMP1 0 0 391 404 1 2
    CASP1 TSLP 0 0 456 456 1 1
    CASP1 SLC2A1 0 0 155 154 1 1
    CASP1 NEDD8 0 0 415 437 1 1
    CASP1 MAP3K13 0 0 161 161 1 1
    CASP1 EGFR 270 0 284 465 1 1
    CASP1 CFLAR 0 0 770 788 1 1
    CASP1 HTT 213 0 262 421 1 1
    CASP1 DEFB103A 0 0 210 210 1 1
    CASP1 TNFRSF4 0 0 144 211 1 1
    CASP1 CLEC1B 0 0 123 185 1 1
    CASP1 RB1CC1 0 0 180 197 1 2
    CASP1 MARCH7 0 0 218 218 1 1
    CASP1 BTN3A1 0 0 82 177 1 1
    CASP1 BRCA1 270 0 166 365 1 1
    CASP1 CCL21 0 0 142 181 1 1
    CASP1 OASL 0 0 194 287 1 1
    CASP1 MAP3K8 0 0 160 228 1 1
    CASP1 OAS3 0 0 104 186 1 1
    CASP1 TFEC 0 0 49 311 1 1
    CASP1 CLEC4A 0 0 122 267 1 1
    CASP1 CTSE 0 0 120 174 1 1
    CASP1 ST20 0 0 0 200 1 1
    CASP1 IL17RC 0 0 164 163 1 1
    CASP1 CASP10 270 0 528 491 1 1
    CASP1 LY75 0 0 181 263 1 1
    CASP1 LAG3 0 0 136 165 1 1
    CASP1 ACTA1 0 0 161 262 1 1
    CASP1 SUCNR1 0 0 95 172 1 1
    CASP1 IL1RL2 0 0 381 393 1 1
    CASP1 FLII 0 0 212 236 1 1
    CASP1 MEFV 270 800 989 999 1 2
    CASP1 P4HB 0 0 155 250 1 2
    CASP1 TMBIM6 0 0 154 160 1 1
    CASP1 ADORA1 0 0 252 263 1 1
    CASP1 TOP1 0 0 141 196 1 1
    CASP1 SERPINA5 0 720 175 759 1 1
    CASP1 TUBA3D 0 0 0 151 1 1
    CASP1 IL2RA 0 0 141 187 1 1
    CASP1 ACP5 0 0 95 203 1 1
    CASP1 FCGR1B 0 0 0 193 1 1
    CASP1 RNF125 0 0 126 166 1 1
    CASP1 ITGAE 0 0 288 289 1 1
    CASP1 IL15 0 0 390 470 1 1
    CASP1 LGMN 0 0 251 250 1 1
    CASP1 PARK2 207 0 292 421 1 1
    CASP1 IFNA1 0 0 560 560 1 1
    CASP1 IL36G 0 0 171 332 1 1
    CASP1 PRB1 0 0 232 231 1 1
    CASP1 TAGAP 0 0 0 266 1 1
    CASP1 PPARGC1A 0 0 261 265 1 1
    CASP1 ADAM10 0 0 427 427 1 1
    CASP1 XBP1 0 0 321 374 1 2
    CASP1 TPPP 0 0 324 323 1 1
    CASP1 TSPAN32 0 0 0 151 1 1
    CASP1 STAT2 0 0 325 378 1 1
    CASP1 TP63 0 900 57 914 1 2
    CASP1 WDR90 0 0 0 158 1 1
    CASP1 ACTRT2 0 0 0 155 1 1
    CASP1 HLA-C 0 0 113 216 1 1
    CASP1 SASH3 0 0 0 296 1 1
    CASP1 MVK 0 0 401 405 1 1
    CASP1 NLRP14 0 0 486 685 1 1
    CASP1 MT-ND1 0 0 66 161 1 1
    CASP1 LAPTM5 0 0 55 396 1 1
    CASP1 ATG5 0 0 621 690 1 2
    CASP1 ITGB3 0 0 113 171 1 1
    CASP1 BCL2L14 0 0 81 415 1 1
    CASP1 TLR8 0 0 518 680 1 1
    CASP1 TUBB 0 0 73 188 1 1
    CASP1 RGS1 0 0 57 179 1 1
    CASP1 BACE1 0 0 210 224 1 1
    CASP1 ITGAM 0 0 596 695 1 1
    CASP1 MAP3K5 0 0 390 442 1 1
    CASP1 ACKR2 0 0 150 163 1 1
    CASP1 PSMC5 0 0 154 173 1 1
    CASP1 IRF5 0 0 324 385 1 1
    CASP1 RAC1 0 0 184 262 1 1
    CASP1 HMGB1 0 0 664 697 1 2
    CASP1 DUOX2 0 0 231 247 1 1
    CASP1 CTSK 0 0 218 269 1 1
    CASP1 LYN 0 0 223 315 1 1
    CASP1 ACTL6B 0 0 0 156 1 1
    CASP1 CST7 0 0 88 227 1 1
    CASP1 POTEB3 0 0 0 155 1 1
    CASP1 NOX1 0 0 261 279 1 1
    CASP1 SPI1 0 0 450 614 1 1
    CASP1 TP53BP1 0 0 156 195 1 1
    CASP1 CTSB 0 0 713 766 1 2
    CASP1 MCL1 0 0 370 486 1 2
    CASP1 SIRT1 0 0 427 447 1 2
    CASP1 CCR7 0 0 268 359 1 1
    CASP1 IKBKG 0 0 458 459 1 1
    CASP1 GPX1 0 0 181 203 1 1
    CASP1 CASR 0 0 263 263 1 1
    CASP1 C1QC 0 0 117 203 1 1
    CASP1 ADK 0 0 141 158 1 1
    CASP1 NEDD1 0 0 307 307 1 1
    CASP1 CXCR5 0 0 155 680 1 1
    CASP1 MAP3K12 0 0 167 167 1 1
    CASP1 SOD3 0 0 92 190 1 1
    CASP1 LILRB3 0 0 0 161 1 1
    CASP1 RPS6KA1 0 0 322 347 1 1
    CASP1 NCAM1 0 0 204 222 1 1
    CASP1 TBX21 0 0 299 361 1 1
    CASP1 DFFB 0 0 415 450 1 1
    CASP1 ACTR3B 0 0 0 154 1 1
    CASP1 MYO1F 0 0 0 201 1 1
    CASP1 WDFY4 0 0 0 354 1 1
    CASP1 ISG15 0 0 335 430 1 1
    CASP1 ADAM17 0 0 287 286 1 1
    CASP1 SERPINB9 270 0 700 771 1 1
    CASP1 SERPINB8 0 0 271 386 1 1
    CASP1 AQP9 0 0 74 240 1 1
    CASP1 NFKBIB 0 0 181 271 1 1
    CASP1 HLA-F 0 0 103 195 1 1
    CASP1 USP18 0 0 170 210 1 1
    CASP1 IL22RA1 0 0 122 162 1 1
    CASP1 ATG10 0 0 167 167 1 2
    CASP1 S100A4 0 0 108 207 1 1
    CASP1 HSPB2 0 0 181 195 1 1
    CASP1 ANTXR2 0 0 162 212 1 1
    CASP1 CEACAM4 0 0 0 213 1 1
    CASP1 ANXA6 0 0 134 164 1 1
    CASP1 CMA1 0 0 391 413 1 1
    CASP1 ENSG00000255819 0 0 210 256 1 1
    CASP1 HSPB1 0 0 211 224 1 1
    CASP1 CCL20 0 0 373 413 1 1
    CASP1 GFAP 45 0 325 360 1 2
    CASP1 CXCR6 0 0 124 167 1 1
    CASP1 CXCL2 0 0 459 548 1 1
    CASP1 COL1A1 0 0 171 171 1 1
    CASP1 NAMPT 0 0 217 232 1 1
    CASP1 PARVG 0 0 0 211 1 1
    CASP1 ATG7 0 0 416 459 1 2
    CASP1 TGFBR2 0 0 181 278 1 1
    CASP1 SELE 0 0 338 353 1 1
    CASP1 TJP1 0 0 294 307 1 1
    CASP1 TRAT1 0 0 341 398 1 1
    CASP1 TAC1 0 0 182 181 1 1
    CASP1 ACTG1 0 0 261 364 1 1
    CASP1 CCL23 0 0 75 156 1 1
    CASP1 CMPK2 0 0 170 257 1 1
    CASP1 IKZF1 0 0 46 158 1 1
    CASP1 SP110 0 0 0 297 1 1
    CASP1 ICAM3 0 0 164 207 1 1
    CASP1 IL23A 0 0 262 283 1 1
    CASP1 CTSD 0 0 377 388 1 2
    CASP1 TYRO3 0 0 136 155 1 1
    CASP1 GPR132 0 0 142 206 1 1
    CASP1 KCNA3 0 0 107 155 1 1
    CASP1 ATM 0 0 245 263 1 1
    CASP1 THBD 0 0 207 270 1 1
    CASP1 LMNB2 0 0 194 225 1 1
    CASP1 TIMP3 0 0 143 215 1 1
    CASP1 ENSG00000258947 0 0 89 215 1 1
    CASP1 MAPK14 0 0 330 426 1 1
    CASP1 CFL1 0 0 180 209 1 1
    CASP1 WDR1 0 0 235 489 1 1
    CASP1 LPXN 0 0 0 172 1 1
    CASP1 SREBF1 0 0 294 299 1 2
    CASP1 ASAP2 0 0 0 163 1 1
    CASP1 LEP 0 0 335 345 1 1
    CASP1 SYK 270 0 520 715 1 1
    CASP1 NFKBIA 0 0 606 672 1 1
    CASP1 FCER1G 0 0 89 267 1 1
    CASP1 PI4KB 379 0 0 389 1 1
    CASP1 WIPI1 0 0 124 215 1 2
    CASP1 CASP5 0 900 988 937 1 1
    CASP1 DNM1L 0 0 288 339 1 2
    CASP1 FFAR4 0 0 266 277 1 1
    CASP1 GABARAP 0 0 149 172 1 2
    CASP1 TXN2 0 0 123 195 1 1
    CASP1 GLIPR1 0 0 0 163 1 1
    CASP1 IRF4 0 0 266 310 1 1
    CASP1 VEGFA 0 0 456 469 1 1
    CASP1 LRR1 0 0 431 482 1 1
    CASP1 PTEN 0 0 390 397 1 2
    CASP1 NEK7 0 0 595 605 1 1
    CASP1 MBP 0 0 205 205 1 1
    CASP1 STX11 0 0 60 255 1 1
    CASP1 P2RX3 0 0 165 165 1 1
    CASP1 HYPK 0 0 0 161 1 1
    CASP1 TRPM2 0 0 246 282 1 1
    CASP1 CXCL1 0 0 518 602 1 1
    CASP1 ATG4D 0 0 135 183 1 2
    CASP1 IL33 488 800 682 968 1 1
    CASP1 GNA15 0 0 0 154 1 1
    CASP1 MMP14 0 0 118 168 1 1
    CASP1 OR2G3 0 0 134 198 1 1
    CASP1 HSPA1B 0 0 46 165 1 1
    CASP1 HSPB8 0 0 92 166 1 2
    CASP1 TNFRSF21 0 0 231 259 1 1
    CASP1 IL1RL1 0 0 482 496 1 1
    CASP1 DAXX 0 0 142 173 1 1
    CASP1 PGLYRP1 0 0 190 216 1 1
    CASP1 TUBE1 0 0 0 161 1 1
    CASP1 NQO1 0 0 267 268 1 1
    CASP1 PSMB9 0 0 210 368 1 1
    CASP1 CCL11 0 0 284 317 1 1
    CASP1 OR1C1 0 0 74 177 1 1
    CASP1 ALOX5 0 0 279 353 1 1
    CASP1 VIL1 0 0 148 174 1 1
    CASP1 CD1B 0 0 146 165 1 1
    CASP1 ATG12 0 0 363 382 1 2
    CASP1 TRIM56 0 0 134 190 1 1
    CASP1 CD28 0 0 325 362 1 1
    CASP1 CD5 0 0 108 179 1 1
    CASP1 CSTB 0 0 209 209 1 1
    CASP1 PPIA 0 0 244 265 1 1
    CASP1 CXCL5 0 0 261 365 1 1
    CASP1 SOCS2 0 0 155 154 1 1
    CASP1 EHBP1L1 0 0 0 186 1 1
    CASP1 ACTL9 0 0 0 155 1 1
    CASP1 PTPN12 0 0 278 293 1 1
    CASP1 CASP4 0 900 910 965 1 2
    CASP1 SLC11A1 0 0 294 360 1 1
    CASP1 ITGAX 0 0 506 577 1 1
    CASP1 SAMHD1 0 0 242 323 1 1
    CASP1 S100A12 0 0 240 345 1 1
    CASP1 NLRP11 0 0 415 432 1 1
    CASP1 KLF2 0 0 108 201 1 1
    CASP1 CHUK 0 0 457 514 1 1
    CASP1 CUL3 270 0 162 362 1 1
    CASP1 KIF1C 0 0 155 216 1 1
    CASP1 TSPO 0 0 243 295 1 1
    CASP1 DNAJA2 0 0 330 330 1 1
    CASP1 PLA2G4B 270 0 0 270 1 1
    CASP1 HCK 0 0 113 306 1 1
    CASP1 UBE2L6 0 0 90 265 1 1
    CASP1 DHFR 0 0 55 164 1 1
    CASP1 SLC25A38 0 0 0 221 1 1
    CASP1 CSF1 0 0 452 509 1 1
    CASP1 DTX3L 0 0 0 230 1 1
    CASP1 HDAC1 0 0 155 154 1 2
    CASP1 PRDM1 0 0 124 179 1 1
    CASP1 FOS 0 0 325 325 1 1
    CASP1 S100A8 0 0 184 332 1 1
    CASP1 CCL27 0 0 167 167 1 1
    CASP1 IL15RA 0 0 123 245 1 1
    CASP1 CLEC9A 0 0 185 233 1 1
    CASP1 PSME2 0 0 81 153 1 1
    CASP1 GAB1 423 0 0 422 1 1
    CASP1 IRG1 0 0 134 192 1 1
    CASP1 FCER1A 0 0 81 189 1 1
    CASP1 PTPN11 0 0 155 155 1 1
    CASP1 MLEC 0 0 0 161 1 1
    CASP1 SIGIRR 0 0 391 404 1 1
    CASP1 IRAK3 0 0 366 480 1 1
    CASP1 CASP14 270 0 465 373 1 1
    CASP1 HSPA5 0 0 321 460 1 2
    CASP1 CCL8 0 0 181 254 1 1
    CASP1 SERP2 0 0 206 206 1 1
    CASP1 FOXO1 0 0 234 240 1 2
    CASP1 SOD2 0 0 323 363 1 1
    CASP1 CCL17 0 0 234 248 1 1
    CASP1 IFNGR1 0 0 228 307 1 1
    CASP1 EEF1D 0 0 97 282 1 1
    CASP1 CCL7 0 0 305 375 1 1
    CASP1 PTGES 0 0 184 183 1 1
    CASP1 IFT57 273 0 128 343 1 1
    CASP1 SLC5A2 0 0 140 151 1 1
    CASP1 ANKRD45 0 0 0 152 1 1
    CASP1 PMAIP1 0 0 286 297 1 1
    CASP1 VAC14 471 0 0 471 1 1
    CASP1 CDKN2B 0 0 107 152 1 1
    CASP1 TLR2 0 0 719 815 1 1
    CASP1 LRRK2 0 0 194 333 1 2
    CASP1 TOLLIP 0 0 240 239 1 1
    CASP1 TRAF3 0 0 405 412 1 2
    CASP1 CD86 0 0 459 612 1 1
    CASP1 WAS 0 0 113 240 1 1
    CASP1 HRH3 0 0 280 291 1 1
    CASP1 P2RY11 0 0 173 173 1 1
    CASP1 BGN 0 0 292 330 1 1
    CASP1 CFB 0 0 158 212 1 1
    CASP1 SHARPIN 0 0 256 260 1 1
    CASP1 NOD1 462 600 851 973 1 1
    CASP1 PDIA3 0 0 112 226 1 1
    CASP1 NOX4 0 0 324 323 1 1
    CASP1 CST3 0 0 181 181 1 1
    CASP1 DROSHA 0 0 107 210 1 1
    CASP1 NLRC4 753 800 989 999 1 2
    CASP1 APOL3 0 0 66 392 1 1
    CASP1 DUOX1 0 0 261 277 1 1
    CASP1 ATP7A 0 0 340 340 1 1
    CASP1 INPP5D 0 0 125 195 1 1
    CASP1 IFIT3 0 0 214 353 1 1
    CASP1 VCAM1 0 0 422 468 1 1
    CASP1 F13A1 0 0 0 150 1 1
    CASP1 FAS 0 0 520 597 1 2
    CASP1 CIRBP 0 0 154 153 1 1
    CASP1 CSF2 0 0 520 540 1 1
    CASP1 PARP4 0 0 0 159 1 1
    CASP1 TH 0 0 182 181 1 1
    CASP1 CD34 0 0 209 209 1 1
    CASP1 UBA7 0 0 66 375 1 1
    CASP1 NGF 0 0 324 335 1 1
    CASP1 ACTL10 0 0 0 155 1 1
    CASP1 TUBAL3 0 0 0 151 1 1
    CASP1 CTSO 0 0 0 151 1 1
    CASP1 PIK3R6 0 0 0 193 1 1
    CASP1 GPR183 0 0 54 196 1 1
    CASP1 CARD6 0 0 411 459 1 1
    CASP1 TNFSF8 0 0 181 305 1 1
    CASP1 LTB4R 0 0 144 173 1 1
    CASP1 MGAM 0 0 81 181 1 1
    CASP1 SQRDL 0 0 0 301 1 1
    CASP1 PRKRA 0 0 292 292 1 1
    CASP1 AIFM1 0 0 134 223 1 1
    CASP1 CYLD 0 0 292 358 1 1
    CASP1 KRT18 0 0 171 172 1 1
    CASP1 AXL 0 0 159 196 1 1
    CASP1 HSP90AB1 0 0 112 263 1 2
    CASP1 IFNGR2 0 0 173 198 1 1
    CASP1 PINK1 0 0 293 305 1 2
    CASP1 BCL6 0 0 167 215 1 1
    CASP1 GJA1 0 0 233 233 1 1
    CASP1 GPT 0 0 373 373 1 1
    CASP1 S100A6 0 0 112 191 1 1
    CASP1 SERPINB3 0 0 96 163 1 1
    CASP1 P2RY13 0 0 143 247 1 1
    CASP1 SERPINB7 0 0 0 179 1 1
    CASP1 RGS18 0 0 0 214 1 1
    CASP1 TXNDC9 0 0 206 256 1 1
    CASP1 CD52 0 0 74 241 1 1
    CASP1 CD180 0 0 81 219 1 1
    CASP1 CD93 0 0 82 178 1 1
    CASP1 BIRC6 0 0 108 284 1 1
    CASP1 TLR3 0 0 652 699 1 1
    CASP1 PARP9 0 0 104 302 1 1
    CASP1 RSAD2 0 0 265 349 1 1
    CASP1 CORO1A 0 0 71 186 1 1
    CASP1 IL19 0 0 181 181 1 1
    CASP1 MIF 0 0 195 195 1 1
    CASP1 ATG3 0 0 282 325 1 2
    CASP1 CDC42 0 0 294 322 1 1
    CASP1 RAG1 0 0 194 194 1 1
    CASP1 F2 0 0 100 160 1 1
    CASP1 ADA 0 0 181 198 1 1
    CASP1 IRF8 0 0 294 427 1 1
    CASP1 APOE 0 0 408 420 1 1
    CASP1 BBOX1 0 0 345 345 1 1
    CASP1 TRPV2 0 0 167 263 1 1
    CASP1 SLC2A4 0 0 210 214 1 1
    CASP1 FOXO3 0 0 294 306 1 2
    CASP1 PLB1 0 0 0 151 1 1
    CASP1 TNFSF11 0 0 285 284 1 1
    CASP1 ACTG2 0 0 48 163 1 1
    CASP1 TEP1 0 0 197 265 1 1
    CASP1 PRKCD 0 0 335 374 1 2
    CASP1 PARP10 0 0 66 211 1 1
    CASP1 MMP10 0 0 124 178 1 1
    CASP1 RIPK3 0 0 632 760 1 1
    CASP1 RAB7B 0 0 259 296 1 1
    CASP1 STAT5B 0 0 235 236 1 1
    CASP1 VDAC1 0 0 327 327 1 2
    CASP1 BTN3A3 0 0 74 298 1 1
    CASP1 TGFB1 0 0 232 353 1 1
    CASP1 GLUL 0 0 151 248 1 1
    CASP1 KDR 0 0 150 183 1 2
    CASP1 GIMAP2 0 0 0 165 1 1
    CASP1 RAB11A 0 0 142 158 1 1
    CASP1 RAC2 0 0 229 431 1 1
    CASP1 KLRB1 0 0 118 187 1 1
    CASP1 TBK1 0 0 520 573 1 2
    CASP1 CLEC5A 0 0 241 334 1 1
    CASP1 TUBB2A 0 0 46 165 1 1
    CASP1 HLA-DOB 0 0 72 204 1 1
    CASP1 FOXP3 0 0 403 411 1 1
    CASP1 PTPN6 0 0 170 220 1 1
    CASP1 PECAM1 0 0 267 321 1 1
    CASP1 PTK2B 0 0 170 227 1 1
    CASP1 ENSG00000264813 0 0 181 181 1 1
    CASP1 FSTL1 0 0 211 211 1 1
    CASP1 RETNLB 0 0 209 209 1 1
    CASP1 S100A10 0 0 171 396 1 1
    CASP1 NUBP2 0 0 310 338 1 1
    CASP1 NPHS2 0 0 218 218 1 1
    CASP1 TXN 0 0 505 566 1 1
    CASP1 LCP1 0 0 0 288 1 1
    CASP1 ANXA7 0 0 136 167 1 2
    CASP1 CD38 0 0 206 252 1 1
    CASP1 CD46 0 0 213 213 1 1
    CASP1 SLC16A8 0 0 261 266 1 1
    CASP1 P2RY6 0 0 202 238 1 1
    CASP1 APOBR 0 0 0 213 1 1
    CASP1 DFFA 0 0 403 412 1 1
    CASP1 LDLR 0 0 247 248 1 1
    CASP1 TUBA1A 0 0 0 151 1 1
    CASP1 CARD18 747 800 748 949 1 1
    CASP1 ACTA2 0 0 60 224 1 1
    CASP1 NOS3 0 0 315 315 1 1
    CASP1 TIMD4 0 0 235 273 1 1
    CASP1 FLI1 0 0 0 151 1 1
    CASP1 TNFRSF10D 0 0 150 182 1 1
    CASP1 CCND1 0 0 261 261 1 1
    CASP1 TXNDC11 0 0 0 171 1 1
    CASP1 CD19 0 0 321 362 1 1
    CASP1 SIGLEC10 0 0 123 169 1 1
    CASP1 IFIT2 0 0 209 337 1 1
    CASP1 PTAFR 0 0 113 183 1 1
    CASP1 ANXA2 0 0 203 226 1 1
    CASP1 VNN2 0 0 0 225 1 1
    CASP1 BLNK 0 0 74 191 1 1
    CASP1 IRAK2 0 0 317 397 1 1
    CASP1 NCF1 0 0 325 413 1 1
    CASP1 ACTR10 0 0 0 155 1 1
    CASP1 CD207 0 0 161 169 1 1
    CASP1 LIPA 0 0 124 165 1 1
    CASP1 HMGCR 0 0 181 181 1 1
    CASP1 IFT43 0 0 710 710 1 1
    CASP1 EIF4E 0 900 103 906 1 1
    CASP1 HIST2H2BE 0 0 160 159 1 1
    CASP1 SLPI 0 0 134 183 1 1
    CASP1 BAD 0 0 166 216 1 1
    CASP1 RFWD2 0 0 0 181 1 1
    CASP1 SOCS1 0 0 320 337 1 1
    CASP1 RAB39A 0 0 388 407 1 1
    CASP1 SLAMF8 0 0 0 230 1 1
    CASP1 BTK 0 0 253 390 1 1
    CASP1 MAPK1 0 0 260 289 1 2
    CASP1 IGF1 0 0 295 316 1 1
    CASP1 DEFB4A 0 0 261 261 1 1
    CASP1 WDFY3 0 0 0 153 1 2
    CASP1 CSF1R 0 0 245 360 1 1
    CASP1 APOB 0 0 193 213 1 1
    CASP1 APOL1 0 0 120 207 1 2
    CASP1 GBP5 0 0 450 587 1 1
    CASP1 PKM 0 0 123 211 1 1
    CASP1 GADD45A 0 0 212 243 1 1
    CASP1 BCL2A1 0 0 293 613 1 1
    CASP1 TYMP 0 0 0 165 1 1
    CASP1 FGF2 270 0 474 600 1 1
    CASP1 CXCL3 0 0 235 351 1 1
    CASP1 BCAP31 270 0 324 488 1 1
    CASP1 RELB 0 0 298 354 1 2
    CASP1 ATN1 213 0 74 240 1 1
    CASP1 POTEI 0 0 0 239 1 1
    CASP1 CMKLR1 0 0 92 196 1 1
    CASP1 CD63 0 0 217 217 1 1
    CASP1 VWF 0 0 194 240 1 1
    CASP1 ENSG00000272980 0 0 241 270 1 1
    CASP1 IFNAR1 0 0 469 493 1 1
    CASP1 TNFAIP6 0 0 134 276 1 1
    CASP1 DDX3X 0 720 143 754 1 1
    CASP1 IL23R 0 0 245 244 1 1
    CASP1 DFNB59 0 0 202 229 1 1
    CASP1 CD209 0 0 333 342 1 1
    CASP1 MMP7 0 0 215 257 1 1
    CASP1 CD300LF 0 0 44 216 1 1
    CASP1 IFI30 0 0 108 227 1 1
    CASP1 TRAF3IP3 0 0 0 165 1 1
    CASP1 CASP2 0 0 710 293 1 1
    CASP1 TMEM71 0 0 67 235 1 1
    CASP1 TJP2 0 0 138 154 1 1
    CASP1 IL7 0 0 272 315 1 1
    CASP1 CD44 0 0 294 381 1 1
    CASP1 BDNF 0 0 370 402 1 2
    CASP1 HLA-DMA 0 0 73 224 1 1
    CASP1 TUBB4B 0 0 0 161 1 1
    CASP1 TIRAP 487 0 463 714 1 1
    CASP1 XDH 0 0 91 178 1 1
    CASP1 HSPA2 0 0 0 170 1 1
    CASP1 TANK 0 0 359 367 1 1
    CASP1 PLA2G2A 0 0 142 160 1 1
    CASP1 YBX1 0 0 59 161 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0050700 Molecular Function CARD domain binding enables IPI
    GO:0008656 Molecular Function cysteine-type endopeptidase activator activity involved in apoptotic process enables TAS
    GO:0004197 Molecular Function cysteine-type endopeptidase activity enables IDA
    GO:0004197 Molecular Function cysteine-type endopeptidase activity enables IGI
    GO:0019955 Molecular Function cytokine binding enables IPI
    GO:0004175 Molecular Function endopeptidase activity enables IDA
    GO:0042802 Molecular Function identical protein binding enables IMP
    GO:0042802 Molecular Function identical protein binding enables IPI
    GO:0019900 Molecular Function kinase binding enables IPI
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0140970 Biological Process AIM2 inflammasome complex assembly involved_in IDA
    GO:0006915 Biological Process apoptotic process involved_in IEA
    GO:0071222 Biological Process cellular response to lipopolysaccharide involved_in IDA
    GO:0071222 Biological Process cellular response to lipopolysaccharide involved_in IMP
    GO:0071260 Biological Process cellular response to mechanical stimulus involved_in IEP
    GO:0071346 Biological Process cellular response to type II interferon involved_in IMP
    GO:0140447 Biological Process cytokine precursor processing involved_in IGI
    GO:0042742 Biological Process defense response to bacterium involved_in ISS
    GO:0051607 Biological Process defense response to virus involved_in NAS
    GO:0046456 Biological Process icosanoid biosynthetic process involved_in NAS
    GO:0007231 Biological Process osmosensory signaling pathway involved_in NAS
    GO:0002221 Biological Process pattern recognition receptor signaling pathway involved_in NAS
    GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IEP
    GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IMP
    GO:0050729 Biological Process positive regulation of inflammatory response involved_in IDA
    GO:0050729 Biological Process positive regulation of inflammatory response involved_in ISO
    GO:0050729 Biological Process positive regulation of inflammatory response involved_in NAS
    GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in IDA
    GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in IMP
    GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in ISO
    GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in NAS
    GO:0032741 Biological Process positive regulation of interleukin-18 production involved_in IDA
    GO:1903265 Biological Process positive regulation of tumor necrosis factor-mediated signaling pathway involved_in IMP
    GO:0016540 Biological Process protein autoprocessing involved_in IDA
    GO:0051604 Biological Process protein maturation involved_in IDA
    GO:0051604 Biological Process protein maturation involved_in ISS
    GO:0006508 Biological Process proteolysis involved_in IDA
    GO:0070269 Biological Process pyroptotic inflammatory response involved_in IDA
    GO:0070269 Biological Process pyroptotic inflammatory response involved_in NAS
    GO:0042981 Biological Process regulation of apoptotic process involved_in IEA
    GO:0050727 Biological Process regulation of inflammatory response involved_in IBA
    GO:0050727 Biological Process regulation of inflammatory response involved_in IDA
    GO:0007165 Biological Process signal transduction involved_in TAS
    GO:0140448 Biological Process signaling receptor ligand precursor processing involved_in IGI
    GO:0097169 Cellular Component AIM2 inflammasome complex part_of IBA
    GO:0097169 Cellular Component AIM2 inflammasome complex part_of IDA
    GO:0097169 Cellular Component AIM2 inflammasome complex part_of IPI
    GO:0072557 Cellular Component IPAF inflammasome complex part_of IBA
    GO:0072557 Cellular Component IPAF inflammasome complex part_of ISS
    GO:0072558 Cellular Component NLRP1 inflammasome complex part_of IDA
    GO:0072558 Cellular Component NLRP1 inflammasome complex part_of IPI
    GO:0072559 Cellular Component NLRP3 inflammasome complex part_of IBA
    GO:0072559 Cellular Component NLRP3 inflammasome complex part_of IDA
    GO:0072559 Cellular Component NLRP3 inflammasome complex part_of IPI
    GO:0061702 Cellular Component canonical inflammasome complex part_of IPI
    GO:0061702 Cellular Component canonical inflammasome complex part_of NAS
    GO:0005737 Cellular Component cytoplasm is_active_in IDA
    GO:0005737 Cellular Component cytoplasm located_in NAS
    GO:0005737 Cellular Component cytoplasm is_active_in TAS
    GO:0005829 Cellular Component cytosol is_active_in IDA
    GO:0005829 Cellular Component cytosol is_active_in ISS
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0005874 Cellular Component microtubule located_in NAS
    GO:0005730 Cellular Component nucleolus located_in NAS
    GO:0005886 Cellular Component plasma membrane located_in IEA
    GO:0097179 Cellular Component protease inhibitor complex part_of IMP
    GO:0032991 Cellular Component protein-containing complex part_of IDA
    GO:0032991 Cellular Component protein-containing complex part_of IMP
    Pathways
    Name DB ID
    Cytokine Signaling in Immune system Reactome R-HSA-1280215
    Disease Reactome R-HSA-1643685
    Innate Immune System Reactome R-HSA-168249
    Immune System Reactome R-HSA-168256
    NOD1/2 Signaling Pathway Reactome R-HSA-168638
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Reactome R-HSA-168643
    Generic Transcription Pathway Reactome R-HSA-212436
    Transcriptional Regulation by TP53 Reactome R-HSA-3700989
    Interleukin-1 family signaling Reactome R-HSA-446652
    Interleukin-1 processing Reactome R-HSA-448706
    Signaling by Interleukins Reactome R-HSA-449147
    Regulated Necrosis Reactome R-HSA-5218859
    Programmed Cell Death Reactome R-HSA-5357801
    Pyroptosis Reactome R-HSA-5620971
    TP53 Regulates Transcription of Cell Death Genes Reactome R-HSA-5633008
    Infectious disease Reactome R-HSA-5663205
    Inflammasomes Reactome R-HSA-622312
    TP53 Regulates Transcription of Caspase Activators and Caspases Reactome R-HSA-6803207
    RNA Polymerase II Transcription Reactome R-HSA-73857
    Gene expression (Transcription) Reactome R-HSA-74160
    The NLRP3 inflammasome Reactome R-HSA-844456
    The AIM2 inflammasome Reactome R-HSA-844615
    The IPAF inflammasome Reactome R-HSA-844623
    Interleukin-37 signaling Reactome R-HSA-9008059
    Leishmania infection Reactome R-HSA-9658195
    Purinergic signaling in leishmaniasis infection Reactome R-HSA-9660826
    Cell recruitment (pro-inflammatory response) Reactome R-HSA-9664424
    SARS-CoV-1 Infection Reactome R-HSA-9678108
    SARS-CoV Infections Reactome R-HSA-9679506
    SARS-CoV-1-host interactions Reactome R-HSA-9692914
    SARS-CoV-1 activates/modulates innate immune responses Reactome R-HSA-9692916
    Parasitic Infection Pathways Reactome R-HSA-9824443
    Viral Infection Pathways Reactome R-HSA-9824446
    Nucleotide-binding oligomerization domain (NOD) pathway (WP1433) WikiPathways WP1433_r122867
    Amyotrophic lateral sclerosis (ALS) (WP2447) WikiPathways WP2447_r113794
    Acute viral myocarditis (WP4298) WikiPathways WP4298_r123508
    Prostaglandin signaling (WP5088) WikiPathways WP5088_r119639
    Unfolded protein response (WP4925) WikiPathways WP4925_r123438
    Nanomaterial-induced inflammasome activation (WP3890) WikiPathways WP3890_r124504
    Activation of NLRP3 inflammasome by SARS-CoV-2 (WP4876) WikiPathways WP4876_r124661
    Apoptosis (WP254) WikiPathways WP254_r118382
    Cytosolic DNA-sensing pathway (WP4655) WikiPathways WP4655_r123496
    Apoptosis modulation and signaling (WP1772) WikiPathways WP1772_r120736
    Malignant pleural mesothelioma (WP5087) WikiPathways WP5087_r122659
    Parkin-ubiquitin proteasomal system pathway (WP2359) WikiPathways WP2359_r123101
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XM_017018395 2 mRNA transcript variant X3 NC_000011 Reference
    XM_017018394 2 mRNA transcript variant X2 NC_000011 Reference
    NM_033295 4 mRNA transcript variant epsilon NC_000011 Reference
    NM_033294 4 mRNA transcript variant delta NC_000011 Reference
    NM_033293 4 mRNA transcript variant gamma NC_000011 Reference
    NM_001223 5 mRNA transcript variant beta NC_000011 Reference
    NM_033292 4 mRNA transcript variant alpha NC_000011 Reference
    XM_017018393 2 mRNA transcript variant X1 NC_000011 Reference
    NM_001257119 3 mRNA transcript variant 7 NC_000011 Reference
    NM_001257118 3 mRNA transcript variant 6 NC_000011 Reference
    XM_017018396 2 mRNA transcript variant X5 NC_000011 Reference
    XM_047427675 1 mRNA transcript variant X4 NC_000011 Reference