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EVA1A

eva-1 homolog A, regulator of programmed cell death
General Information
Name eva-1 homolog A, regulator of programmed cell death
Alias
  • protein eva-1 homolog A
  • family with sequence similarity 176, member A
  • protein FAM176A
  • transmembrane protein 166
Gene_family
organism Homo sapiens
entrez_id 84141
location 2p12
transcript_count 4
exon_count 7
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Predicted to be involved in apoptotic process and autophagy. Located in intracellular membrane-bounded organelle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Stringdb Protein eva-1 homolog A; Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis
    nextProt Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
EVA1A BioGRID MS4A13 GeneID BioGRID Two-hybrid
EVA1A BioGRID SGTB GeneID BioGRID Two-hybrid
EVA1A BioGRID TSPAN4 GeneID BioGRID Two-hybrid
EVA1A BioGRID GYPA GeneID BioGRID Two-hybrid
EVA1A BioGRID CA9 GeneID BioGRID Proximity Label-MS
EVA1A BioGRID TP63 GeneID BioGRID Positive Genetic
EVA1A BioGRID MAP1LC3B GeneID BioGRID Reconstituted Complex
EVA1A BioGRID ATG16L1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
EVA1A BioGRID MTNR1B GeneID BioGRID Two-hybrid
EVA1A Protein SAT1 GeneID HPRD
EVA1A Protein PTN GeneID HPRD
EVA1A BioGRID SAT1 GeneID BioGRID Two-hybrid
EVA1A BioGRID PTN GeneID BioGRID Two-hybrid
StringDB
A B experiments database textmining combined score hadb nhadb
EVA1A TMEM59 0 0 505 636 1 1
EVA1A KIAA0319 0 0 457 457 1 1
EVA1A HEPACAM 0 0 177 177 1 1
EVA1A PRICKLE3 0 0 0 207 1 1
EVA1A MFAP2 0 0 137 189 1 1
EVA1A ENSG00000100926 0 0 561 568 1 1
EVA1A KIAA0319L 0 0 217 239 1 1
EVA1A CYP4F11 0 0 174 192 1 1
EVA1A PIK3R4 0 0 140 176 1 2
EVA1A PI15 0 0 0 206 1 1
EVA1A IMPA1 0 0 161 176 1 1
EVA1A CLNK 0 0 69 165 1 1
EVA1A CASP9 0 0 57 161 1 2
EVA1A FAM83D 0 0 184 308 1 1
EVA1A PDK4 0 0 135 165 1 1
EVA1A TMEM57 0 0 257 256 1 1
EVA1A LCA5 0 0 167 167 1 1
EVA1A OSBPL3 0 0 194 362 1 1
EVA1A ATP2C2 0 0 323 323 1 1
EVA1A HSPB3 0 0 338 338 1 1
EVA1A NES 0 0 69 202 1 2
EVA1A AHI1 0 0 0 189 1 1
EVA1A ATG5 0 0 261 280 1 2
EVA1A GABARAPL2 0 0 154 166 1 2
EVA1A TMEM106C 0 0 108 204 1 1
EVA1A CRYGS 0 0 157 156 1 1
EVA1A KIF1A 0 0 0 189 1 1
EVA1A COL4A2 0 0 0 153 1 1
EVA1A YAP1 0 0 0 151 1 2
EVA1A HSPA4 0 0 391 390 1 1
EVA1A TP63 209 0 0 209 1 2
EVA1A NNT 0 0 134 166 1 1
EVA1A FAM46D 0 0 112 176 1 1
EVA1A TMEM74 0 0 517 532 1 2
EVA1A RPL23 0 0 231 230 1 1
EVA1A GYPA 272 0 0 272 1 1
EVA1A S100A16 0 0 0 153 1 1
EVA1A CTGF 0 0 0 255 1 1
EVA1A ATG10 0 0 244 253 1 2
EVA1A TDP2 0 0 134 166 1 1
EVA1A RPS6KB2 0 0 0 206 1 2
EVA1A PINK1 0 0 75 155 1 2
EVA1A HSPB1 0 0 368 383 1 2
EVA1A HSPB2 0 0 363 363 1 1
EVA1A RAB3A 0 0 0 188 1 1
EVA1A EIF4EBP1 0 0 113 462 1 2
EVA1A MAP1LC3B 270 0 229 423 1 2
EVA1A ERP27 0 0 232 231 1 1
EVA1A SGIP1 0 0 209 209 1 1
EVA1A FAM19A5 0 0 211 211 1 1
EVA1A TRIM9 0 0 161 600 1 1
EVA1A ARL4D 0 0 209 227 1 1
EVA1A NGLY1 0 0 175 175 1 1
EVA1A DSTN 0 0 171 191 1 1
EVA1A SCLT1 0 0 67 164 1 1
EVA1A TM4SF1 0 0 0 179 1 1
EVA1A TGFBI 0 0 48 158 1 1
EVA1A PDE1C 0 0 148 169 1 1
EVA1A FN1 0 0 54 223 1 2
EVA1A GALNT13 0 0 209 424 1 1
EVA1A ANXA5 0 0 82 252 1 2
EVA1A NPPA 0 0 70 163 1 1
EVA1A PLEKHF1 0 0 202 202 1 1
EVA1A METTL24 0 0 458 457 1 1
EVA1A PRDX3 0 0 425 424 1 1
EVA1A SUPT20H 0 0 180 179 1 1
EVA1A DYX1C1 0 0 392 392 1 1
EVA1A EML5 0 0 95 234 1 1
EVA1A PRICKLE2 0 0 0 273 1 1
EVA1A ANKRD52 0 0 0 209 1 1
EVA1A SP2 0 0 223 223 1 1
EVA1A SRPX 0 0 0 181 1 1
EVA1A PRICKLE1 0 0 134 580 1 1
EVA1A CYR61 0 0 0 211 1 1
EVA1A SP8 0 0 341 341 1 1
EVA1A GCFC2 0 0 508 508 1 1
EVA1A NCKAP5 0 0 232 645 1 1
EVA1A DKK1 0 0 0 183 1 1
EVA1A MMP1 0 0 0 167 1 1
EVA1A ACRBP 0 0 218 218 1 1
EVA1A DIP2A 0 0 201 217 1 1
EVA1A MAP1LC3C 0 0 193 204 1 2
EVA1A ATG7 0 0 234 247 1 2
EVA1A MRPL19 0 0 517 517 1 1
EVA1A TFPI2 0 0 0 183 1 1
EVA1A ATG3 0 0 210 224 1 2
EVA1A DNAJB1 0 0 232 231 1 2
EVA1A RPS6 0 0 50 309 1 2
EVA1A SKAP2 0 0 136 582 1 1
EVA1A GLMN 0 0 64 228 1 1
EVA1A FAM124B 0 0 112 205 1 1
EVA1A LOXL2 0 0 0 175 1 1
EVA1A PIK3C3 0 0 204 205 1 2
EVA1A THOC5 0 0 175 175 1 1
EVA1A ATG16L2 0 0 260 291 1 2
EVA1A EXOC4 0 0 112 450 1 1
EVA1A COL1A1 0 0 0 151 1 2
EVA1A GABARAP 0 0 232 280 1 2
EVA1A PLBD1 0 0 210 512 1 1
EVA1A ID1 0 0 113 156 1 1
EVA1A FAM13C 0 0 276 389 1 1
EVA1A FAP 0 0 0 151 1 2
EVA1A GLIPR1 0 0 150 614 1 1
EVA1A FOXL1 0 0 0 151 1 1
EVA1A YTHDC2 0 0 0 189 1 1
EVA1A WIPI1 0 0 134 152 1 2
EVA1A SNAI2 0 0 0 213 1 1
EVA1A RNF207 0 0 0 189 1 1
EVA1A ARPC1B 0 0 137 170 1 1
EVA1A TOMM20 0 0 70 324 1 2
EVA1A TRIT1 0 0 166 165 1 1
EVA1A HAS2 0 0 75 284 1 1
EVA1A KIAA0226 0 0 128 219 1 1
EVA1A WIPF3 0 0 248 248 1 1
EVA1A SLC5A6 0 0 230 229 1 1
EVA1A TSC2 0 0 55 221 1 2
EVA1A AMBRA1 0 0 150 224 1 2
EVA1A PTRF 0 0 0 151 1 1
EVA1A DOCK4 0 0 142 174 1 1
EVA1A TRIM67 0 0 0 246 1 1
EVA1A MAP1LC3A 0 0 202 215 1 2
EVA1A DYNLRB2 0 0 207 207 1 1
EVA1A MFN2 0 0 57 314 1 2
EVA1A EPHA2 0 0 0 181 1 1
EVA1A VEGFC 0 0 0 248 1 1
EVA1A SQSTM1 0 0 260 374 1 2
EVA1A BNIP3 0 0 96 236 1 2
EVA1A YTHDC1 0 0 125 494 1 1
EVA1A NRSN1 0 0 245 270 1 1
EVA1A ANKRD50 0 0 256 698 1 1
EVA1A TSPAN4 118 0 0 150 1 1
EVA1A SYDE1 0 0 0 213 1 1
EVA1A OXSR1 0 0 181 404 1 1
EVA1A ACOT13 0 0 181 198 1 1
EVA1A APOBR 0 0 203 203 1 1
EVA1A HSPE1 0 0 171 171 1 1
EVA1A DCDC2 0 0 372 372 1 1
EVA1A EML6 0 0 122 360 1 1
EVA1A KDELR3 0 0 0 151 1 1
EVA1A ATG12 0 0 244 243 1 2
EVA1A XKR6 0 0 212 212 1 1
EVA1A ATG13 0 0 171 260 1 2
EVA1A PRMT2 0 0 125 157 1 1
EVA1A FSTL1 0 0 0 153 1 1
EVA1A NKAIN1 0 0 95 161 1 1
EVA1A CASP3 0 0 123 220 1 2
EVA1A TRIB3 0 0 85 163 1 2
EVA1A SCAMP2 0 0 183 183 1 1
EVA1A PARG 0 0 103 500 1 1
EVA1A HSPB8 0 0 341 341 1 2
EVA1A ATG101 0 0 162 181 1 2
EVA1A FAM46B 0 0 272 436 1 1
EVA1A HSP90AA1 0 0 324 323 1 2
EVA1A MMP14 0 0 0 152 1 1
EVA1A SRPX2 0 0 0 183 1 1
EVA1A FAM46C 0 0 156 287 1 1
EVA1A SERPINE1 0 0 0 213 1 1
EVA1A NCKAP1 0 0 152 181 1 1
EVA1A LCTL 0 0 0 303 1 1
EVA1A GABARAPL1 0 0 134 157 1 2
EVA1A ROBO1 0 0 241 240 1 1
EVA1A ERO1LB 0 0 321 321 1 1
EVA1A EGFR 0 0 0 161 1 2
EVA1A RPS6KB1 0 0 125 364 1 2
EVA1A LOX 0 0 0 213 1 2
EVA1A COMMD2 0 0 152 237 1 1
EVA1A TWIST2 0 0 0 151 1 1
EVA1A TOMM20L 0 0 0 181 1 1
EVA1A ATG16L1 270 0 482 606 1 2
EVA1A PIK3CD 0 0 0 171 1 1
EVA1A MTTP 0 0 155 154 1 1
EVA1A PI16 0 0 0 206 1 1
EVA1A SESTD1 0 0 235 235 1 1
EVA1A SP9 0 0 370 370 1 1
EVA1A OSBPL6 0 0 234 631 1 1
EVA1A TRIM44 0 0 269 269 1 1
EVA1A FAM43B 0 0 508 615 1 1
EVA1A MICAL2 0 0 182 181 1 1
EVA1A FOXC2 0 0 0 151 1 1
EVA1A HSPA8 0 0 260 260 1 2
EVA1A TRIM65 0 0 183 200 1 1
EVA1A VPS37B 0 0 205 205 1 1
EVA1A MICAL3 0 0 185 185 1 1
EVA1A GPX8 0 0 51 160 1 1
EVA1A CCND1 0 0 54 151 1 2
EVA1A LOXL1 0 0 0 183 1 1
EVA1A KRT7 0 0 0 170 1 1
EVA1A APOC3 0 0 182 202 1 1
EVA1A SLC4A11 0 0 112 156 1 1
EVA1A RND3 0 0 0 153 1 1
EVA1A GALNT1 0 0 0 187 1 1
EVA1A TXNIP 0 0 58 202 1 2
EVA1A KIRREL 0 0 0 214 1 1
EVA1A IGFBP3 0 0 0 183 1 2
EVA1A TMEM106A 0 0 270 433 1 1
EVA1A MFN1 0 0 0 151 1 2
EVA1A CDK17 0 0 73 236 1 1
EVA1A TNFRSF12A 0 0 0 151 1 1
EVA1A MYO3B 0 0 205 205 1 1
EVA1A RAI14 0 0 0 151 1 1
EVA1A CMIP 0 0 283 282 1 1
EVA1A RAB3C 0 0 60 315 1 1
EVA1A RNASE9 0 0 0 189 1 1
EVA1A LAMB1 0 0 0 157 1 1
EVA1A SP6 0 0 162 161 1 1
EVA1A PTPN18 0 0 193 249 1 1
EVA1A FAM57B 0 0 108 350 1 1
EVA1A CABLES1 0 0 208 208 1 1
EVA1A COL12A1 0 0 0 213 1 1
EVA1A TNC 0 0 0 151 1 1
EVA1A RB1CC1 0 0 244 296 1 2
EVA1A WDR16 0 0 309 685 1 1
EVA1A FAM83B 0 0 235 357 1 1
EVA1A FBXO16 0 0 119 313 1 1
EVA1A GNG12 0 0 0 183 1 1
EVA1A APOB 0 0 391 390 1 2
EVA1A KRTAP2-3 0 0 0 158 1 1
EVA1A ZAK 0 0 72 324 1 1
EVA1A LCT 0 0 0 303 1 1
EVA1A NBR1 0 0 231 311 1 2
EVA1A MPZL2 0 0 457 548 1 1
EVA1A ANKRD28 0 0 0 209 1 1
EVA1A ZNF91 0 0 181 181 1 1
EVA1A KLB 0 0 0 187 1 1
EVA1A PLBD2 0 0 97 259 1 1
EVA1A TM9SF1 0 0 560 567 1 2
EVA1A IRGM 0 0 108 185 1 2
EVA1A PPP5C 0 0 157 156 1 1
EVA1A MGST3 0 0 163 163 1 1
EVA1A ERRFI1 0 0 112 190 1 1
EVA1A KL 0 0 0 187 1 2
EVA1A STARD13 0 0 123 155 1 1
EVA1A NT5E 0 0 0 200 1 1
EVA1A FRMD6 0 0 0 151 1 1
EVA1A WIPI2 0 0 190 239 1 2
EVA1A NR2F6 0 0 135 153 1 1
EVA1A KIF1B 0 0 103 400 1 1
EVA1A AGBL5 0 0 218 692 1 1
EVA1A PIK3CA 0 0 73 326 1 2
EVA1A PIK3CB 0 0 0 171 1 1
EVA1A CAV1 0 0 0 290 1 2
EVA1A CHST1 0 0 183 183 1 1
EVA1A COL8A2 0 0 218 234 1 1
EVA1A ACRV1 0 0 393 392 1 1
EVA1A NNMT 0 0 0 214 1 1
EVA1A RTP5 0 0 167 167 1 1
EVA1A PELO 0 0 245 244 1 1
EVA1A ACPT 0 0 241 240 1 1
EVA1A MEFV 0 0 134 166 1 1
EVA1A BECN1 0 0 218 218 1 2
EVA1A MYO16 0 0 216 216 1 1
EVA1A GM2A 0 0 150 382 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005515 Molecular Function protein binding enables IPI
GO:0006915 Biological Process apoptotic process involved_in IEA
GO:0006914 Biological Process autophagy involved_in IEA
GO:0005788 Cellular Component endoplasmic reticulum lumen located_in TAS
GO:0005789 Cellular Component endoplasmic reticulum membrane located_in IEA
GO:0043231 Cellular Component intracellular membrane-bounded organelle located_in IDA
GO:0005765 Cellular Component lysosomal membrane located_in IEA
GO:0005886 Cellular Component plasma membrane located_in IDA
Pathways
Name DB ID
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Reactome R-HSA-381426
Metabolism of proteins Reactome R-HSA-392499
Post-translational protein modification Reactome R-HSA-597592
Post-translational protein phosphorylation Reactome R-HSA-8957275
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_032181 3 mRNA transcript variant 2 NC_000002 Reference
NM_001369524 1 mRNA transcript variant 3 NC_000002 Reference
NM_001135032 2 mRNA transcript variant 1 NC_000002 Reference
NM_001369525 1 mRNA transcript variant 4 NC_000002 Reference