HAdb 2.0 is available now!

CASR

calcium sensing receptor
General Information
Name calcium sensing receptor
Alias
  • extracellular calcium-sensing receptor
  • parathyroid Ca(2+)-sensing receptor 1
  • parathyroid cell calcium-sensing receptor 1
Gene_family Calcium sensing receptors
organism Homo sapiens
entrez_id 846
location 3q13.33-q21.1
transcript_count 6
exon_count 11
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]
    Stringdb Extracellular calcium-sensing receptor; G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. The G-protein- coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as [...]
    nextProt G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
CASR BioGRID GABBR2 GeneID BioGRID Affinity Capture-Western
CASR BioGRID GABBR1 GeneID BioGRID Affinity Capture-Western
CASR BioGRID GRM1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
CASR BioGRID HACE1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
CASR BioGRID CASR GeneID BioGRID Co-crystal Structure; Reconstituted Complex
CASR BioGRID NOTCH3 GeneID BioGRID Affinity Capture-Western
CASR BioGRID NOTCH2 GeneID BioGRID Affinity Capture-Western
CASR BioGRID NOTCH1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
CASR BioGRID VHL GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
CASR BioGRID PPP1R12A GeneID BioGRID Affinity Capture-Western
CASR BioGRID HIF1A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
CASR BioGRID NFKBIA GeneID BioGRID Affinity Capture-Western; Two-hybrid
CASR BioGRID Os9 GeneID BioGRID Two-hybrid
CASR BioGRID OS9 GeneID BioGRID Affinity Capture-Western
CASR BioGRID PRKCG GeneID BioGRID Biochemical Activity
CASR BioGRID PRKCB GeneID BioGRID Biochemical Activity
CASR BioGRID PRKCA GeneID BioGRID Biochemical Activity
CASR BioGRID STAMBP GeneID BioGRID Affinity Capture-Western; Two-hybrid
CASR BioGRID RNF19A GeneID BioGRID Affinity Capture-Western
CASR BioGRID VCP GeneID BioGRID Affinity Capture-Western
CASR Protein PI4K2B GeneID HPRD
CASR Protein RNF19A GeneID HPRD
CASR Protein CASR GeneID HPRD
CASR Protein FLNA GeneID HPRD
CASR Protein PRKCG GeneID HPRD
CASR Protein PRKCB GeneID HPRD
CASR Protein PRKCA GeneID HPRD
CASR BioGRID CHD8 GeneID BioGRID Affinity Capture-Western
CASR BioGRID FLNA GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
StringDB
A B experiments database textmining combined score hadb nhadb
CASR DSPP 0 0 166 165 1 1
CASR ITGB1 0 0 137 581 1 1
CASR PRAMEF2 0 0 392 392 1 1
CASR SLC6A19 0 0 247 263 1 1
CASR PPP2R1B 0 0 0 153 1 1
CASR KNG1 0 0 203 203 1 1
CASR TMIE 0 0 0 160 1 1
CASR GPR148 0 0 208 231 1 1
CASR ALB 0 0 511 515 1 2
CASR MRGPRF 0 0 152 167 1 1
CASR RPL19 0 0 0 213 1 1
CASR GPR98 0 0 96 267 1 1
CASR MYLK 0 0 179 188 1 1
CASR SCT 0 0 391 404 1 1
CASR AVPR1B 0 0 97 176 1 1
CASR FAM155B 0 0 107 296 1 1
CASR SPARC 0 0 161 170 1 2
CASR TRPM4 0 0 213 260 1 1
CASR IL17F 0 0 290 290 1 1
CASR ADRA2B 0 0 140 153 1 1
CASR GIPR 0 0 260 349 1 1
CASR NOTCH3 270 0 74 295 1 1
CASR DDC 0 0 398 407 1 1
CASR SLC12A2 0 0 280 308 1 1
CASR TAS2R8 0 600 0 626 1 1
CASR ADCY5 0 0 95 187 1 1
CASR SCARA5 0 0 0 394 1 1
CASR CDH1 0 0 370 370 1 2
CASR RYR1 0 0 66 175 1 2
CASR RDH14 0 0 90 377 1 1
CASR FAM83H 0 0 0 207 1 1
CASR AIM2 0 0 194 194 1 2
CASR WNT16 0 0 108 181 1 1
CASR CHRM3 0 0 137 190 1 1
CASR C4B 0 0 0 189 1 1
CASR CCR10 0 0 53 211 1 1
CASR SLC26A1 0 0 162 188 1 1
CASR IAPP 0 0 204 240 1 2
CASR ALK 0 0 46 194 1 2
CASR TAS2R50 0 600 0 620 1 1
CASR MAP1B 0 0 48 156 1 2
CASR AQP2 0 0 502 505 1 1
CASR IL1A 0 0 125 179 1 1
CASR CLDN16 0 0 681 689 1 1
CASR AVP 0 0 287 304 1 1
CASR TAS2R19 0 600 0 625 1 1
CASR GLP2R 0 0 193 218 1 1
CASR CLDN12 0 0 205 219 1 1
CASR TAS2R40 0 600 270 774 1 1
CASR TBCE 0 0 318 317 1 1
CASR DRD2 0 0 212 257 1 1
CASR DPP4 0 0 194 211 1 1
CASR NR3C2 0 0 154 153 1 1
CASR CRHR2 0 0 120 199 1 1
CASR PTGER4 0 0 138 178 1 1
CASR TAS2R4 0 600 194 740 1 1
CASR FLG 0 0 193 193 1 1
CASR RAMP2 0 0 285 556 1 1
CASR FXR1 0 0 0 325 1 1
CASR MAP1S 0 0 57 469 1 2
CASR P2RX7 0 0 113 168 1 2
CASR MTR 0 0 88 246 1 1
CASR STIM2 0 0 202 207 1 1
CASR GRM3 0 600 241 617 1 1
CASR VR1 0 0 212 240 1 1
CASR GABBR2 270 600 268 763 1 1
CASR PDE1C 0 0 138 175 1 1
CASR SLC26A3 0 0 213 226 1 1
CASR AKAP13 0 0 453 453 1 1
CASR CALCA 0 0 602 648 1 1
CASR ADIPOQ 0 0 160 159 1 2
CASR NLRP5 0 0 442 442 1 1
CASR EGF 0 0 272 289 1 2
CASR BMP2 0 0 342 342 1 1
CASR CYP27A1 0 0 261 262 1 1
CASR IGFBP1 0 0 292 292 1 1
CASR RNF19A 270 0 212 411 1 1
CASR CYCS 0 0 184 183 1 2
CASR SCTR 0 0 296 316 1 1
CASR POMC 0 0 255 254 1 1
CASR ITPR1 0 0 524 594 1 2
CASR IL18BP 0 0 0 303 1 1
CASR CASP9 0 0 142 192 1 2
CASR KCNJ16 0 0 261 283 1 1
CASR GNAS 0 0 230 712 1 1
CASR PPY 0 0 145 195 1 1
CASR SLC8A3 0 0 123 167 1 1
CASR DLG5 0 0 0 155 1 1
CASR ATP2C2 0 0 181 191 1 1
CASR TRPC6 0 0 391 399 1 1
CASR CRHR1 0 0 205 286 1 1
CASR GCGR 0 0 296 367 1 1
CASR GHRHR 0 0 486 491 1 1
CASR MC1R 0 0 81 185 1 1
CASR PDZD2 0 0 0 164 1 1
CASR GATA4 0 0 62 200 1 2
CASR C1orf141 0 0 193 229 1 1
CASR PLCG1 0 0 445 445 1 1
CASR JUN 0 0 255 254 1 2
CASR SNTG2 0 0 81 245 1 1
CASR ITPR3 0 0 402 490 1 1
CASR CYP19A1 0 0 158 176 1 2
CASR KL 0 0 710 736 1 2
CASR CALB1 0 0 247 302 1 1
CASR GRIN2C 0 0 0 221 1 1
CASR PLCB4 0 800 0 807 1 1
CASR TAS2R31 0 600 0 709 1 1
CASR FFAR2 0 0 393 392 1 1
CASR OTOP1 0 0 92 430 1 1
CASR SLC8A1 0 0 293 328 1 1
CASR VWA8 0 0 246 245 1 1
CASR PROP1 0 0 357 357 1 1
CASR CAV1 0 0 226 225 1 2
CASR CASP1 0 0 263 263 1 2
CASR SLC9A8 0 0 134 158 1 1
CASR PI4K2B 213 0 0 213 1 1
CASR PLCH2 0 0 0 160 1 1
CASR SSTR3 0 0 87 180 1 1
CASR SLC7A9 0 0 182 250 1 1
CASR GRIN2D 0 0 0 221 1 1
CASR OSTF1 0 0 92 262 1 1
CASR IGFBP3 0 0 296 296 1 2
CASR SHH 0 0 216 216 1 2
CASR USH1G 0 0 0 167 1 1
CASR TRPM6 0 0 519 525 1 1
CASR CCR5 0 0 269 280 1 1
CASR AIP 0 0 140 150 1 1
CASR CSTA 0 0 218 245 1 1
CASR SSTR5 0 0 134 238 1 1
CASR OR5C1 0 0 247 323 1 1
CASR VCP 270 0 0 270 1 2
CASR GHRH 0 0 481 481 1 1
CASR JAG1 0 0 171 171 1 1
CASR FYN 0 900 129 913 1 1
CASR GRIN2A 0 0 74 247 1 1
CASR GALNT3 0 0 242 243 1 1
CASR RGS14 0 0 218 218 1 1
CASR UNC80 0 0 294 464 1 1
CASR TAS2R38 0 600 194 737 1 1
CASR ZNF683 0 0 91 193 1 1
CASR GPR84 0 0 249 311 1 1
CASR EFHC1 0 0 323 323 1 1
CASR PTPRN 0 0 328 339 1 1
CASR ADORA2A 0 0 141 175 1 1
CASR TRPM5 0 0 293 301 1 1
CASR ADH1B 0 0 267 280 1 1
CASR TAS2R1 0 600 143 695 1 1
CASR CYP2R1 0 0 413 428 1 1
CASR IGFBP2 0 0 306 306 1 1
CASR NPSR1 0 0 170 182 1 1
CASR SOST 0 0 424 424 1 1
CASR SLC15A1 0 0 400 449 1 1
CASR PLA2G1B 0 0 232 232 1 1
CASR TAS2R46 0 600 0 625 1 1
CASR SLC38A2 0 0 170 205 1 1
CASR PYY 0 0 458 482 1 1
CASR TULP3 0 0 0 150 1 1
CASR CXCL12 0 0 233 232 1 2
CASR SPP1 0 0 459 459 1 2
CASR CA5B 0 0 0 200 1 1
CASR TAS2R14 0 600 96 647 1 1
CASR JUP 0 0 108 173 1 1
CASR GNRH1 0 0 213 244 1 1
CASR KCNH2 0 0 160 159 1 1
CASR AR 0 0 163 163 1 2
CASR RHOA 0 0 233 238 1 2
CASR ROS1 0 0 0 190 1 1
CASR MAPK3 0 0 460 480 1 2
CASR MMP9 0 0 170 169 1 2
CASR GRASP 0 0 0 252 1 1
CASR TAS2R60 0 600 128 707 1 1
CASR GABRD 0 0 233 253 1 1
CASR ZNF2 0 0 489 489 1 1
CASR ACTB 0 0 290 306 1 2
CASR SELP 0 0 94 187 1 1
CASR INS 0 0 451 578 1 2
CASR TAS2R41 0 600 181 746 1 1
CASR SLC7A3 0 0 0 201 1 1
CASR EPRS 0 0 72 169 1 1
CASR FPR2 0 0 154 167 1 1
CASR CAV2 0 0 432 432 1 1
CASR GLP1R 0 0 285 333 1 1
CASR CLDN10 0 0 112 151 1 1
CASR CAMK2N2 0 0 0 159 1 1
CASR TES 0 0 436 441 1 1
CASR PRSS1 0 0 562 562 1 1
CASR PKD1L3 0 0 103 590 1 1
CASR RGS12 0 0 407 407 1 1
CASR ELF2 0 0 62 207 1 1
CASR PSEN1 0 0 108 189 1 2
CASR CRP 0 0 397 396 1 2
CASR CALHM1 0 0 209 209 1 1
CASR SP7 0 0 315 320 1 1
CASR SLC9A3 0 0 305 320 1 1
CASR KLK3 0 0 155 154 1 1
CASR IL6R 0 0 306 306 1 1
CASR UNC79 0 0 325 522 1 1
CASR CXCL8 0 0 181 181 1 2
CASR KCNQ1 0 0 170 194 1 1
CASR HOGA1 0 0 243 309 1 1
CASR WNK3 0 0 160 159 1 1
CASR DLG2 0 0 0 191 1 1
CASR PDZK1 0 0 67 151 1 1
CASR IL1B 0 0 325 325 1 2
CASR WNT7B 0 0 108 157 1 1
CASR PRKCB 463 0 48 488 1 2
CASR TRPM7 0 0 455 461 1 1
CASR GCK 0 0 95 151 1 1
CASR CPA6 0 0 113 355 1 1
CASR CYP27B1 0 0 563 590 1 1
CASR FZD4 0 0 113 210 1 1
CASR HIF1A 486 0 166 552 1 2
CASR EDN1 0 0 208 222 1 1
CASR VIPR2 0 0 140 378 1 1
CASR GPR101 0 0 166 207 1 1
CASR CXCR2 0 0 113 176 1 1
CASR DHCR7 0 0 181 181 1 1
CASR RHO 0 0 457 512 1 2
CASR APP 0 0 134 180 1 2
CASR TRPV1 0 0 212 240 1 2
CASR TMEM181 0 0 0 396 1 1
CASR SCN1A 0 0 112 215 1 1
CASR CDC73 0 0 681 683 1 1
CASR ATP6V1B1 0 0 193 294 1 1
CASR CTNNB1 0 0 565 565 1 2
CASR SOCS7 0 0 0 295 1 1
CASR OLFM2 0 0 280 403 1 1
CASR C4A 0 0 0 189 1 1
CASR CALM1 0 0 0 202 1 1
CASR MTOR 0 0 183 194 1 2
CASR NLRP1 0 0 134 152 1 1
CASR TRPV6 0 0 507 557 1 1
CASR GPR1 0 0 93 163 1 1
CASR GABRA1 0 0 211 216 1 1
CASR NOTCH1 270 0 182 377 1 2
CASR CXCR4 0 0 284 295 1 2
CASR PSEN2 0 0 74 162 1 1
CASR LSMEM2 0 0 241 240 1 1
CASR KCNMA1 0 0 124 217 1 1
CASR GRM8 0 600 261 620 1 1
CASR BRD2 0 0 135 198 1 1
CASR TBL1XR1 0 0 323 323 1 1
CASR NALCN 0 0 324 566 1 1
CASR IL6 0 0 341 341 1 2
CASR GRM7 0 600 293 623 1 1
CASR PPP1R12A 270 0 0 281 1 1
CASR PRKG1 0 0 46 150 1 1
CASR CREB1 0 0 210 211 1 2
CASR RAPGEF3 0 0 167 167 1 1
CASR NSF 0 0 69 387 1 2
CASR GAST 0 0 469 483 1 1
CASR GPRC5A 0 0 194 215 1 1
CASR TANGO6 0 0 145 168 1 1
CASR TAS2R9 0 600 113 694 1 1
CASR ATP1A3 0 0 0 177 1 1
CASR MBOAT4 0 0 161 161 1 1
CASR NAA11 0 0 92 154 1 1
CASR RYR2 0 0 139 237 1 1
CASR GPR179 0 0 260 463 1 1
CASR CYP17A1 0 0 167 167 1 1
CASR CA5A 0 0 95 154 1 1
CASR SDHB 0 0 141 157 1 1
CASR CA2 0 0 206 223 1 1
CASR PTGER1 0 0 129 173 1 1
CASR EPO 0 0 170 169 1 2
CASR GRIK2 0 0 91 182 1 1
CASR PHEX 0 0 370 377 1 1
CASR GJD2 0 0 134 186 1 1
CASR RGS4 0 0 150 160 1 1
CASR SCNN1D 0 0 81 656 1 1
CASR CTNND1 0 0 122 174 1 1
CASR TRPC1 0 0 455 480 1 1
CASR RAPGEF4 0 0 155 187 1 1
CASR LAMTOR5 0 0 0 213 1 1
CASR GRIA4 0 0 0 163 1 1
CASR RYR3 0 0 123 226 1 1
CASR GRIA2 0 0 60 180 1 1
CASR ZNF551 0 0 154 165 1 1
CASR SLC17A4 0 0 75 213 1 1
CASR CXADR 0 0 229 228 1 1
CASR TPO 0 0 244 243 1 1
CASR ITPR2 0 0 90 224 1 1
CASR GRK4 0 0 134 194 1 1
CASR SLC9A1 0 0 151 170 1 1
CASR CLDN15 0 0 171 171 1 1
CASR CALCR 0 0 421 454 1 1
CASR TAS2R30 0 600 0 625 1 1
CASR S100G 0 0 413 423 1 1
CASR GNRHR 0 0 260 295 1 1
CASR UMOD 0 0 284 325 1 1
CASR TAAR1 0 0 112 277 1 1
CASR SLC12A7 0 0 161 175 1 1
CASR CYSLTR2 0 0 99 161 1 1
CASR GRHPR 0 0 194 243 1 1
CASR SLC20A2 0 0 322 353 1 1
CASR TRPC3 0 0 482 520 1 1
CASR ZFYVE16 0 0 123 215 1 1
CASR LPAR5 0 0 456 456 1 1
CASR GAPDH 0 0 293 305 1 2
CASR FAM111A 0 0 380 380 1 1
CASR STK19 0 0 203 203 1 1
CASR TLR4 0 0 150 168 1 2
CASR SMAD2 0 0 124 151 1 2
CASR CYP1A2 0 0 306 306 1 1
CASR SLC20A1 0 0 134 193 1 1
CASR OR7C1 0 0 0 169 1 1
CASR RGS10 0 0 161 162 1 1
CASR TPH1 0 0 262 323 1 1
CASR PLCB3 0 800 73 825 1 1
CASR TAS2R7 0 600 228 712 1 1
CASR OR1D5 0 0 181 181 1 1
CASR RALGDS 0 0 67 168 1 1
CASR IL18 0 0 181 199 1 2
CASR WNT5A 0 0 282 297 1 2
CASR MYC 0 0 218 218 1 2
CASR CACNB4 0 0 194 220 1 1
CASR SLC12A3 0 0 469 478 1 1
CASR ACP5 0 0 321 321 1 1
CASR NDNL2 0 0 0 298 1 1
CASR PLCB2 0 800 261 851 1 1
CASR NTS 0 0 194 209 1 1
CASR ADORA1 0 0 157 188 1 1
CASR GNAQ 0 800 921 985 1 1
CASR MEFV 0 0 150 168 1 1
CASR IBSP 0 0 283 282 1 1
CASR MEN1 0 0 653 653 1 1
CASR P4HB 0 0 58 159 1 2
CASR SLC7A1 0 0 0 201 1 1
CASR TAB1 0 0 90 254 1 1
CASR GNAT3 0 0 256 322 1 1
CASR GLS 0 0 63 232 1 2
CASR STC1 0 0 459 678 1 1
CASR SLC34A2 0 0 181 192 1 1
CASR KCNN3 0 0 107 153 1 1
CASR TMC6 0 0 109 198 1 1
CASR CHGA 0 0 210 255 1 1
CASR LRP5 0 0 284 299 1 1
CASR FLNA 486 0 975 988 1 1
CASR TAS2R42 0 600 122 633 1 1
CASR MAGI1 0 0 66 182 1 1
CASR AQP1 0 0 180 199 1 1
CASR WNK4 0 0 261 265 1 1
CASR RTDR1 0 0 218 235 1 1
CASR MAP2K1 0 0 180 192 1 1
CASR BRCA1 0 0 386 386 1 2
CASR NPY 0 0 181 193 1 1
CASR GRPR 0 0 180 216 1 1
CASR GRIN3B 0 0 45 191 1 1
CASR PRSS3P2 0 0 417 416 1 1
CASR NUDT10 0 0 206 206 1 1
CASR CHRM5 0 0 50 170 1 1
CASR ATP2C1 0 0 150 214 1 1
CASR EGFR 0 0 234 245 1 2
CASR ADORA3 0 0 150 163 1 1
CASR GPR39 0 0 284 296 1 1
CASR FFAR1 0 0 468 480 1 1
CASR HOMER2 0 0 0 314 1 1
CASR FGFR3 0 0 134 185 1 1
CASR TAC4 0 0 134 188 1 1
CASR DGKH 0 0 334 349 1 1
CASR TRIM24 0 0 297 297 1 1
CASR CFTR 0 0 518 524 1 2
CASR CNNM2 0 0 218 238 1 1
CASR PRKCE 0 0 45 179 1 1
CASR SLC26A7 0 0 112 173 1 1
CASR RGS5 0 0 112 154 1 1
CASR IVL 0 0 261 261 1 1
CASR TP53 0 0 195 215 1 2
CASR SLC26A4 0 0 205 218 1 1
CASR TGM2 0 0 108 158 1 2
CASR ORAI1 0 0 303 308 1 1
CASR TNFRSF11B 0 0 501 502 1 1
CASR ADH1A 0 0 339 351 1 1
CASR SLC9A3R2 0 0 58 173 1 1
CASR NTSR1 0 0 156 169 1 1
CASR ME2 0 0 124 452 1 1
CASR SCUBE2 0 0 103 192 1 1
CASR VKORC1L1 0 0 289 288 1 1
CASR SLC2A2 0 0 203 238 1 1
CASR LMNA 0 0 60 158 1 2
CASR ATP2B4 0 0 140 159 1 1
CASR TAS2R5 0 600 57 606 1 1
CASR CALM3 0 0 0 153 1 1
CASR CLU 0 0 203 220 1 2
CASR RTP3 0 0 150 193 1 1
CASR CACNA1D 0 0 134 152 1 1
CASR SLURP1 0 0 47 183 1 1
CASR SLC5A1 0 0 298 326 1 1
CASR GPR156 0 0 144 239 1 1
CASR SCNN1B 0 0 160 181 1 1
CASR GHRL 0 0 324 326 1 1
CASR WNK1 0 0 181 181 1 1
CASR CLCN5 0 0 454 454 1 1
CASR SCNN1G 0 0 95 190 1 1
CASR MST1 0 0 45 251 1 2
CASR TGFA 0 0 109 302 1 1
CASR SUCLG1 0 0 328 328 1 1
CASR GATA3 0 0 270 313 1 1
CASR OCRL 0 0 175 226 1 1
CASR TAS2R20 0 600 122 656 1 1
CASR CLCNKB 0 0 681 711 1 1
CASR MBP 0 0 148 198 1 2
CASR PTEN 0 0 134 165 1 2
CASR TNFRSF11A 0 0 180 179 1 1
CASR VEGFA 0 0 241 240 1 2
CASR GC 0 0 404 404 1 1
CASR GPR68 0 0 270 270 1 1
CASR NFATC1 0 0 251 297 1 2
CASR SCARA3 0 0 46 409 1 1
CASR FFAR4 0 0 465 493 1 1
CASR TAS2R16 0 600 122 802 1 1
CASR ATXN1L 0 0 124 169 1 1
CASR SLC7A7 0 0 108 166 1 1
CASR NFKBIA 270 0 107 335 1 2
CASR LEP 0 0 212 212 1 1
CASR FAM20A 0 0 155 213 1 1
CASR CCKBR 0 0 162 181 1 1
CASR PKD2L1 0 0 134 266 1 1
CASR NPY1R 0 0 91 173 1 1
CASR CDX2 0 0 184 183 1 1
CASR PTH1R 0 0 559 583 1 1
CASR MAPK14 0 0 214 232 1 2
CASR PTH2R 0 0 293 305 1 1
CASR GUCY2D 0 0 54 156 1 1
CASR KLHL3 0 0 148 179 1 1
CASR CA4 0 0 82 172 1 1
CASR CCL28 0 0 203 203 1 1
CASR GNAI1 0 800 297 856 1 1
CASR LHCGR 0 0 306 321 1 1
CASR NT5C1A 0 0 279 279 1 1
CASR RET 0 0 391 390 1 1
CASR NR1H4 0 0 150 215 1 1
CASR KRTAP13-3 0 0 407 407 1 1
CASR CPLX2 0 0 107 260 1 1
CASR PRSS58 0 0 407 407 1 1
CASR DLG4 0 0 57 228 1 2
CASR TAC1 0 0 182 199 1 1
CASR TGFBR2 0 0 0 230 1 1
CASR GPR15 0 0 113 220 1 1
CASR SELE 0 0 66 162 1 1
CASR SPACA3 0 0 74 442 1 1
CASR TJP1 0 0 166 254 1 1
CASR COL1A1 0 0 158 157 1 2
CASR LPHN1 0 0 123 159 1 1
CASR PPP3R1 0 0 328 338 1 1
CASR FGFR4 0 0 150 188 1 1
CASR IL10 0 0 157 156 1 2
CASR ATP2B1 0 0 358 381 1 1
CASR ADRB1 0 0 194 206 1 1
CASR KCNN4 0 0 292 323 1 1
CASR MST1R 0 0 0 190 1 1
CASR GALC 0 0 0 183 1 1
CASR ESPN 0 0 0 150 1 1
CASR LOR 0 0 266 266 1 1
CASR GUCY1B3 0 0 96 173 1 1
CASR KPTN 0 0 0 200 1 1
CASR HHAT 0 0 137 210 1 1
CASR CALCRL 0 0 324 381 1 1
CASR MAMDC4 0 0 0 190 1 1
CASR HOMER3 0 0 0 175 1 1
CASR CAMK2A 0 0 0 184 1 2
CASR GUCY2C 0 0 193 229 1 1
CASR STK39 0 0 249 248 1 1
CASR CACNA1E 0 0 103 187 1 1
CASR PRKCA 270 0 195 411 1 1
CASR OR4X1 0 0 140 231 1 1
CASR ALDH4A1 0 0 0 335 1 1
CASR C3 0 0 53 310 1 2
CASR GAL 0 0 194 207 1 1
CASR PTH2 0 0 96 161 1 1
CASR IKBKG 0 0 165 165 1 1
CASR AP2S1 0 0 720 762 1 1
CASR SSTR1 0 0 142 231 1 1
CASR FN1 0 0 185 185 1 2
CASR AIRE 0 0 392 401 1 1
CASR PRL 0 0 253 252 1 1
CASR CTSB 0 0 211 211 1 2
CASR BAI1 0 0 61 175 1 1
CASR RGS2 0 0 144 175 1 1
CASR ESR1 0 0 295 295 1 2
CASR COPS5 0 0 46 258 1 1
CASR CTSK 0 0 325 325 1 2
CASR P2RY2 0 0 146 164 1 1
CASR HOMER1 0 0 85 431 1 1
CASR TRPA1 0 0 181 224 1 1
CASR GNA11 0 800 611 921 1 1
CASR BACE1 0 0 157 156 1 2
CASR DKK4 0 0 113 164 1 1
CASR AVPR2 0 0 509 570 1 1
CASR DSG1 0 0 113 249 1 1
CASR PAPSS2 0 0 193 193 1 1
CASR PRKD1 0 0 143 176 1 1
CASR CRH 0 0 123 156 1 1
CASR GRIN1 0 0 0 246 1 1
CASR WNT3A 0 0 175 193 1 2
CASR CAMK2G 0 0 0 184 1 1
CASR ATP4A 0 0 287 286 1 1
CASR TAS2R39 0 600 244 717 1 1
CASR GRM2 0 600 283 620 1 1
CASR GNAI3 0 800 0 803 1 2
CASR SLC41A1 0 0 170 191 1 1
CASR MALRD1 0 0 0 190 1 1
CASR GLIS3 0 0 60 155 1 1
CASR PDIA3 0 0 62 155 1 1
CASR KCNJ15 0 0 425 426 1 1
CASR ATP6V0A4 0 0 241 304 1 1
CASR CHRM4 0 0 184 235 1 1
CASR ATP1A1 0 0 115 168 1 1
CASR IFNA13 0 0 306 306 1 1
CASR MCHR1 0 0 113 156 1 1
CASR GPR173 0 0 105 163 1 1
CASR GABBR1 270 600 840 955 1 1
CASR GNAO1 0 0 142 158 1 1
CASR GRIN2B 0 0 71 245 1 1
CASR CDKN2C 0 0 161 174 1 1
CASR PICK1 0 0 42 199 1 1
CASR MET 0 0 57 203 1 2
CASR ERF 0 0 81 178 1 1
CASR FGF23 0 0 764 764 1 1
CASR PIK3CB 0 0 74 172 1 1
CASR LRP2 0 0 260 281 1 1
CASR ADCY10 0 0 242 241 1 1
CASR KIAA1919 0 0 150 173 1 1
CASR NAP1L4 0 0 56 153 1 1
CASR ACPT 0 0 0 208 1 1
CASR CAMK2B 0 0 0 184 1 1
CASR LGI1 0 0 85 155 1 1
CASR GPBAR1 0 0 284 289 1 1
CASR TAS1R3 0 600 803 665 1 1
CASR SLC34A3 0 0 510 569 1 1
CASR PTH 0 0 907 913 1 1
CASR ADRBK1 0 0 142 195 1 1
CASR SLC2A9 0 0 143 185 1 1
CASR GPR119 0 0 458 478 1 1
CASR CASP14 0 0 282 282 1 1
CASR VIPR1 0 0 261 346 1 1
CASR RAMP1 0 0 508 685 1 1
CASR PDX1 0 0 92 174 1 1
CASR GUCA2A 0 0 167 186 1 1
CASR CLDN2 0 0 408 420 1 1
CASR SCNN1A 0 0 120 209 1 1
CASR DGKD 0 0 323 338 1 1
CASR SNCB 0 0 54 318 1 1
CASR FOS 0 0 206 206 1 2
CASR GHSR 0 0 210 222 1 1
CASR CSF1 0 0 155 154 1 1
CASR KCNJ10 0 0 372 372 1 1
CASR TRPV5 0 0 743 771 1 1
CASR AHSG 0 0 440 440 1 1
CASR FGF11 0 0 44 201 1 1
CASR SLC4A1 0 0 170 218 1 1
CASR FGF9 0 0 146 166 1 1
CASR CHD8 270 0 0 340 1 1
CASR TG 0 0 141 200 1 1
CASR SLC9A2 0 0 171 193 1 1
CASR WNT2 0 0 74 220 1 1
CASR INSRR 0 0 0 198 1 1
CASR GSK3B 0 0 123 191 1 2
CASR GRIN3A 0 0 0 155 1 1
CASR ARRB1 0 0 325 353 1 1
CASR ADM 0 0 166 209 1 2
CASR MGP 0 0 458 457 1 1
CASR CDKN2A 0 0 174 186 1 2
CASR CALM2 0 0 0 153 1 1
CASR SST 0 0 332 359 1 1
CASR ARRB2 0 0 294 323 1 1
CASR TRPC4 0 0 218 223 1 1
CASR GRM1 270 500 663 980 1 1
CASR GPR65 0 0 165 178 1 1
CASR DLG3 0 0 0 191 1 1
CASR FPR3 0 0 151 164 1 1
CASR PSMC4 0 0 641 641 1 1
CASR GPER1 0 0 141 282 1 2
CASR REN 0 0 459 481 1 1
CASR IHH 0 0 184 195 1 1
CASR NOTCH2 270 0 0 270 1 1
CASR ACE 0 0 281 296 1 1
CASR CASP3 0 0 268 313 1 2
CASR GPRC5C 0 0 155 154 1 1
CASR PTGS2 0 0 211 211 1 2
CASR TUB 0 0 0 211 1 1
CASR LTK 0 0 44 192 1 1
CASR ENPP1 0 0 218 218 1 1
CASR SSTR2 0 0 218 260 1 1
CASR CCKAR 0 0 210 228 1 1
CASR SLC4A3 0 0 133 167 1 1
CASR GNA15 0 0 234 234 1 1
CASR NLRP3 0 0 334 334 1 2
CASR OS9 270 0 63 286 1 1
CASR CPSF4 0 0 53 199 1 1
CASR GPR25 0 0 141 225 1 1
CASR OR7C2 0 0 263 361 1 1
CASR CUBN 0 0 195 229 1 1
CASR AGTR2 0 0 137 185 1 1
CASR SLC13A2 0 0 240 283 1 1
CASR ITIH1 0 0 45 214 1 1
CASR CLDN4 0 0 83 165 1 1
CASR DMP1 0 0 97 193 1 1
CASR CLCN7 0 0 108 171 1 1
CASR TAS2R13 0 600 0 600 1 1
CASR CSN3 0 0 142 170 1 1
CASR MC4R 0 0 279 294 1 1
CASR TSC2 0 0 88 150 1 2
CASR HACE1 270 0 0 282 1 1
CASR TGFB1 0 0 134 157 1 2
CASR FAM155A 0 0 0 155 1 1
CASR GRM6 0 600 150 609 1 1
CASR CDA 0 0 69 463 1 1
CASR CDKN1B 0 0 341 341 1 2
CASR TRPV4 0 0 282 302 1 1
CASR MCU 0 0 140 181 1 2
CASR WDR72 0 0 137 211 1 1
CASR TNFSF11 0 0 530 539 1 2
CASR GPRC5D 0 0 120 175 1 1
CASR ZFPM2 0 0 326 325 1 1
CASR BGLAP 0 0 519 525 1 1
CASR PCSK9 0 0 75 170 1 1
CASR TRPV2 0 0 230 240 1 1
CASR APOE 0 0 204 204 1 2
CASR OXT 0 0 135 153 1 1
CASR DKK1 0 0 269 269 1 1
CASR SRC 0 0 218 241 1 2
CASR STAMBP 270 0 181 392 1 1
CASR CLDN19 0 0 556 556 1 1
CASR SLC34A1 0 0 470 514 1 1
CASR PKD1 0 0 174 173 1 1
CASR CDKN3 0 0 155 154 1 1
CASR FRMPD2 0 0 0 152 1 1
CASR CAMK2D 0 0 0 184 1 1
CASR VHL 270 0 0 270 1 2
CASR CKAP2 0 0 210 267 1 1
CASR TXNDC9 0 0 441 441 1 1
CASR CPA2 0 0 0 160 1 1
CASR HNF4A 0 0 156 155 1 1
CASR EIF2AK3 0 0 181 198 1 2
CASR ADRA1B 0 0 171 240 1 1
CASR GPR142 0 0 469 695 1 1
CASR COMT 0 0 57 156 1 1
CASR TSPAN17 0 0 82 318 1 1
CASR OR51E1 0 0 123 187 1 1
CASR ADH4 0 0 294 316 1 1
CASR SLC7A2 0 0 72 423 1 1
CASR ITPKC 0 0 155 161 1 1
CASR MAG 0 0 0 187 1 1
CASR TAS1R1 0 600 749 659 1 1
CASR GRM5 0 500 526 928 1 1
CASR TAS2R10 0 600 0 610 1 1
CASR CTRC 0 0 650 650 1 1
CASR CCK 0 0 458 471 1 1
CASR GJA1 0 0 193 193 1 1
CASR BSND 0 0 669 677 1 1
CASR SLC12A1 0 0 654 680 1 1
CASR OSGEP 0 0 125 163 1 1
CASR GRIK4 0 0 0 180 1 1
CASR CA10 0 0 310 325 1 1
CASR GPRC5B 0 0 283 520 1 1
CASR EDNRB 0 0 134 206 1 1
CASR PCDH17 0 0 53 215 1 1
CASR TYMS 0 0 203 203 1 1
CASR TPM3 0 0 202 211 1 1
CASR GPRC6A 0 800 866 831 1 1
CASR PKD2 0 0 234 247 1 2
CASR TSPAN5 0 0 0 256 1 1
CASR CD34 0 0 144 162 1 2
CASR CPA1 0 0 369 387 1 1
CASR SHBG 0 0 103 180 1 1
CASR NLRP7 0 0 124 160 1 1
CASR TH 0 0 294 309 1 2
CASR GPR64 0 0 114 189 1 1
CASR KCNJ1 0 0 663 678 1 1
CASR AKT1 0 0 340 383 1 2
CASR TMED2 270 0 475 600 1 1
CASR PPARG 0 0 218 218 1 2
CASR RAMP3 0 0 476 750 1 1
CASR GGT1 0 0 152 239 1 1
CASR GRIK1 0 0 108 191 1 1
CASR PTHLH 0 0 681 681 1 1
CASR MEPE 0 0 297 297 1 1
CASR PRKCG 270 0 0 299 1 1
CASR ARL15 0 0 0 250 1 1
CASR GNAL 0 0 0 428 1 1
CASR VCAM1 0 0 113 307 1 1
CASR INSL5 0 0 150 212 1 1
CASR VIP 0 0 202 214 1 1
CASR FGFR1 0 0 240 256 1 1
CASR NLRC4 0 0 181 181 1 2
CASR ACE2 0 0 112 150 1 2
CASR SLC26A6 0 0 212 225 1 1
CASR COL1A2 0 0 149 183 1 1
CASR PANX1 0 0 134 160 1 1
CASR FXR2 0 0 0 325 1 1
CASR DLG1 0 0 0 191 1 1
CASR RUNX2 0 0 454 465 1 2
CASR TNF 0 0 285 286 1 2
CASR HNRNPD 0 0 108 150 1 1
CASR PLCB1 0 800 123 823 1 1
CASR IFITM1 0 0 326 325 1 1
CASR GABRG2 0 0 117 168 1 1
CASR MAGED2 0 0 247 575 1 1
CASR SRR 0 0 92 188 1 1
CASR BDNF 0 0 81 173 1 2
CASR CD44 0 0 156 155 1 2
CASR VDR 0 0 740 745 1 2
CASR GNAI2 0 800 60 807 1 1
CASR ATP11C 0 0 124 220 1 1
CASR ADCY6 0 0 201 237 1 1
CASR TSHR 0 0 293 309 1 1
CASR GPR4 0 0 233 246 1 1
CASR ALDH7A1 0 0 150 162 1 1
CASR HCN3 0 0 72 325 1 1
CASR SLC13A1 0 0 74 190 1 1
CASR FMR1 0 0 0 325 1 1
CASR GRM4 0 600 393 631 1 1
CASR ASIC2 0 0 115 152 1 1
CASR NFAT5 0 0 125 218 1 1
CASR PAH 0 0 385 399 1 1
CASR AGT 0 0 135 204 1 1
CASR SLC3A1 0 0 171 190 1 1
CASR GCG 0 0 468 483 1 1
CASR TNNT2 0 0 119 210 1 1
CASR ATP12A 0 0 286 286 1 1
CASR FGF2 0 0 143 162 1 2
CASR PCBD1 0 0 170 169 1 1
CASR TAS1R2 0 600 602 653 1 1
CASR ADM2 0 0 48 282 1 1
CASR SFRP4 0 0 194 194 1 1
CASR CNR1 0 0 183 201 1 1
CASR FFAR3 0 0 362 373 1 1
CASR GBP5 0 0 143 205 1 1
CASR CASK 0 0 0 180 1 1
CASR ROR2 0 0 124 187 1 1
CASR IGF1 0 0 304 304 1 2
CASR PPP2R1A 0 0 0 153 1 1
CASR GRIA3 0 0 46 168 1 1
CASR GCM1 0 0 536 536 1 1
CASR AGTR1 0 0 242 253 1 1
CASR GRP 0 0 210 230 1 2
CASR FXYD2 0 0 280 307 1 1
CASR ADRB2 0 0 325 335 1 1
CASR EIF4E 0 0 0 179 1 2
CASR EDNRA 0 0 136 161 1 1
CASR ASIC1 0 0 43 153 1 2
CASR CYP24A1 0 0 556 587 1 1
CASR ADRA1D 0 0 66 265 1 1
CASR SAG 0 0 393 392 1 1
CASR KCNA1 0 0 150 201 1 1
CASR ATP2B2 0 0 325 374 1 1
CASR BLNK 0 0 52 151 1 1
CASR TRH 0 0 170 221 1 1
CASR GCM2 0 0 756 782 1 1
CASR CCDC58 0 0 167 167 1 1
CASR ADH5 0 0 67 210 1 1
CASR STIM1 0 0 294 299 1 2
CASR NPY5R 0 0 66 162 1 1
CASR MTHFR 0 0 167 177 1 1
CASR AQP3 0 0 125 222 1 1
CASR CCND1 0 0 336 336 1 2
CASR AGXT 0 0 170 176 1 1
CASR FSHR 0 0 204 231 1 1
CASR NOS3 0 0 181 198 1 2
CASR MYOZ3 0 0 0 215 1 1
CASR PC 0 0 0 213 1 1
CASR TAS2R3 0 600 203 760 1 1
CASR GALR1 0 0 88 260 1 1
CASR GPR158 0 0 218 432 1 1
CASR ATP2A2 0 0 210 216 1 1
CASR GPR35 0 0 161 161 1 1
CASR RGS22 0 0 155 494 1 1
CASR HPRT1 0 0 113 186 1 1
CASR ALPL 0 0 294 294 1 1
CASR CLCNKA 0 0 391 449 1 1
CASR OPRM1 0 0 149 173 1 1
CASR GRIA1 0 0 67 186 1 1
CASR CANX 0 0 216 340 1 2
CASR SLC9A3R1 0 0 258 374 1 1
CASR CLDN14 0 0 650 663 1 1
CASR LRP6 0 0 142 182 1 1
CASR ENSG00000264813 0 0 276 291 1 1
CASR GRIK5 0 0 72 206 1 1
CASR INADL 0 0 0 184 1 1
CASR GUCY2F 0 0 60 161 1 1
CASR AP2B1 0 0 155 154 1 1
CASR GIP 0 0 295 295 1 1
CASR PLCH1 0 0 0 208 1 1
CASR SPINK1 0 0 595 595 1 1
CASR TBX1 0 0 203 203 1 1
CASR TAS2R43 0 600 0 625 1 1
CASR EMP1 0 0 218 297 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0004930 Molecular Function G protein-coupled receptor activity enables IBA
GO:0004930 Molecular Function G protein-coupled receptor activity enables IDA
GO:0016597 Molecular Function amino acid binding enables IDA
GO:0005509 Molecular Function calcium ion binding enables IBA
GO:0005509 Molecular Function calcium ion binding enables IDA
GO:0005178 Molecular Function integrin binding enables IEA
GO:0004435 Molecular Function phosphatidylinositol phospholipase C activity enables TAS
GO:0005515 Molecular Function protein binding enables IPI
GO:0042803 Molecular Function protein homodimerization activity enables IDA
GO:0019901 Molecular Function protein kinase binding enables IEA
GO:0044325 Molecular Function transmembrane transporter binding enables IEA
GO:0007186 Biological Process G protein-coupled receptor signaling pathway involved_in IDA
GO:0007186 Biological Process G protein-coupled receptor signaling pathway involved_in IMP
GO:0007254 Biological Process JNK cascade involved_in IEA
GO:0007193 Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway involved_in IEA
GO:0009653 Biological Process anatomical structure morphogenesis involved_in TAS
GO:0032782 Biological Process bile acid secretion involved_in IEA
GO:0048754 Biological Process branching morphogenesis of an epithelial tube involved_in IEA
GO:0070509 Biological Process calcium ion import involved_in IDA
GO:0071333 Biological Process cellular response to glucose stimulus involved_in IEA
GO:0035729 Biological Process cellular response to hepatocyte growth factor stimulus involved_in IEA
GO:0071456 Biological Process cellular response to hypoxia involved_in IEA
GO:0071404 Biological Process cellular response to low-density lipoprotein particle stimulus involved_in IEA
GO:1901653 Biological Process cellular response to peptide involved_in IEA
GO:0071305 Biological Process cellular response to vitamin D involved_in IEA
GO:0007635 Biological Process chemosensory behavior involved_in TAS
GO:1902476 Biological Process chloride transmembrane transport involved_in IEA
GO:0005513 Biological Process detection of calcium ion involved_in IBA
GO:0005513 Biological Process detection of calcium ion involved_in IDA
GO:0060613 Biological Process fat pad development involved_in IEA
GO:0006874 Biological Process intracellular calcium ion homeostasis involved_in IBA
GO:0006874 Biological Process intracellular calcium ion homeostasis involved_in IDA
GO:0001503 Biological Process ossification involved_in IEA
GO:0007200 Biological Process phospholipase C-activating G protein-coupled receptor signaling pathway involved_in IEA
GO:0070374 Biological Process positive regulation of ERK1 and ERK2 cascade involved_in IEA
GO:0090280 Biological Process positive regulation of calcium ion import involved_in IEA
GO:0008284 Biological Process positive regulation of cell population proliferation involved_in IEA
GO:0010628 Biological Process positive regulation of gene expression involved_in IEA
GO:0032024 Biological Process positive regulation of insulin secretion involved_in IEA
GO:0050927 Biological Process positive regulation of positive chemotaxis involved_in IEA
GO:0045907 Biological Process positive regulation of vasoconstriction involved_in IEA
GO:0051924 Biological Process regulation of calcium ion transport involved_in IBA
GO:0071774 Biological Process response to fibroblast growth factor involved_in IEA
GO:0002931 Biological Process response to ischemia involved_in IEA
GO:0042311 Biological Process vasodilation involved_in IEA
GO:0016324 Cellular Component apical plasma membrane located_in IEA
GO:0043679 Cellular Component axon terminus located_in IEA
GO:0016323 Cellular Component basolateral plasma membrane located_in IEA
GO:0009986 Cellular Component cell surface located_in IEA
GO:0043025 Cellular Component neuronal cell body located_in IEA
GO:0005886 Cellular Component plasma membrane located_in IDA
GO:0005886 Cellular Component plasma membrane located_in TAS
Pathways
Name DB ID
Signal Transduction Reactome R-HSA-162582
Signaling by GPCR Reactome R-HSA-372790
GPCR downstream signalling Reactome R-HSA-388396
G alpha (q) signalling events Reactome R-HSA-416476
G alpha (i) signalling events Reactome R-HSA-418594
Class C/3 (Metabotropic glutamate/pheromone receptors) Reactome R-HSA-420499
GPCR ligand binding Reactome R-HSA-500792
GPCRs, class C metabotropic glutamate, pheromone (WP501) WikiPathways WP501_r117742
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_000388 4 mRNA transcript variant 2 NC_000003 Reference
NM_001178065 2 mRNA transcript variant 1 NC_000003 Reference
XM_006713789 4 mRNA transcript variant X1 NC_000003 Reference
XM_047449065 1 mRNA transcript variant X4 NC_000003 Reference
XM_017007324 2 mRNA transcript variant X2 NC_000003 Reference
XM_017007325 2 mRNA transcript variant X3 NC_000003 Reference