SNX4

sorting nexin 4

General Information

Name	sorting nexin 4
Alias	sorting nexin-4
Gene_family	Sorting nexins\|Autophagy related\|PX-BAR domain containing
organism	Homo sapiens
entrez_id	8723
location	3q21.2
transcript_count	3
exon_count	15

Cross References

Location

by NCBI GRCh38.p14

Summary

Entrez This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]

Stringdb Sorting nexin-4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation; Belongs to the sorting nexin family

nextProt Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011). Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622).

Interactions

NCBI

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SNX4	BioGRID	M	GeneID	BioGRID	Proximity Label-MS
SNX4	BioGRID	PRNP	GeneID	BioGRID	Affinity Capture-MS
SNX4	BioGRID	RAB11A	GeneID	BioGRID	Proximity Label-MS
SNX4	BioGRID	TRIM67	GeneID	BioGRID	Affinity Capture-MS
SNX4	BioGRID	PRKN	GeneID	BioGRID	Affinity Capture-MS
SNX4	BioGRID	XPO5	GeneID	BioGRID	Co-fractionation
SNX4	BioGRID	DYNC1LI1	GeneID	BioGRID	Co-fractionation
SNX4	BioGRID	NUDCD3	GeneID	BioGRID	Co-fractionation
SNX4	BioGRID	DYNLL1	GeneID	BioGRID	Co-fractionation
SNX4	BioGRID	TPR	GeneID	BioGRID	Co-fractionation

Showing 1 to 10 of 71 entries

StringDB

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SNX4	ACADM	0	0	184	1	1
SNX4	FIS1	0	0	162	1	2
SNX4	ALDH18A1	0	90	216	1	1
SNX4	CHMP2A	0	182	259	1	1
SNX4	SYN2	360	0	360	1	1
SNX4	NAA35	0	235	258	1	1
SNX4	WFDC13	0	0	153	1	1
SNX4	UGT1A10	0	0	181	1	1
SNX4	WIPI2	0	150	424	1	2
SNX4	CNOT8	0	0	155	1	1

Showing 1 to 10 of 894 entries

Ontologies

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GO:0005154	Molecular Function	epidermal growth factor receptor binding	enables	IDA
GO:0005158	Molecular Function	insulin receptor binding	enables	IDA
GO:0005515	Molecular Function	protein binding	enables	IPI
GO:0005737	Cellular Component	cytoplasm	located_in	IDA
GO:0005769	Cellular Component	early endosome	is_active_in	IDA
GO:0005868	Cellular Component	cytoplasmic dynein complex	part_of	IDA
GO:0005886	Cellular Component	plasma membrane	is_active_in	IBA
GO:0005886	Cellular Component	plasma membrane	located_in	IDA
GO:0015031	Biological Process	protein transport	involved_in	IBA
GO:0015031	Biological Process	protein transport	involved_in	IMP

Showing 1 to 10 of 27 entries

Pathways

Name	DB	ID

Transcripts

Accession	Version	MolecularType	Name	NCBI	Comments
NR_073435	2	miscRNA	transcript variant 2	NC_000003	Reference
NM_003794	4	mRNA	transcript variant 1	NC_000003	Reference
XM_017007414	3	mRNA	transcript variant X1	NC_000003	Reference