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RIPK1

receptor interacting serine/threonine kinase 1
General Information
Name receptor interacting serine/threonine kinase 1
Alias
  • receptor-interacting serine/threonine-protein kinase 1
  • cell death protein RIP
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • receptor-interacting protein 1
  • receptor-interacting protein kinase 1
  • serine/threonine-protein kinase RIP
Gene_family Ripoptosome
organism Homo sapiens
entrez_id 8737
location 6p25.2
transcript_count 15
exon_count 18
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]
    Stringdb Receptor-interacting serine/threonine-protein kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with do [...]
    nextProt Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:32657447, PubMed:31827280, PubMed:31827281, PubMed:17703191). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591, PubMed:15310755). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
RIPK1 BioGRID N GeneID BioGRID Proximity Label-MS
RIPK1 BioGRID DNAJA3 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID CASP8 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-localization; Reconstituted Complex
RIPK1 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID TNF GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RIPK1 BioGRID CCNF GeneID BioGRID Proximity Label-MS
RIPK1 BioGRID ORF1ab GeneID BioGRID Affinity Capture-MS; Two-hybrid
RIPK1 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RIPK1 BioGRID FADD GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
RIPK1 BioGRID TOP2A GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID PSMB4 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID PSMA5 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID NBR1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID H2AZ1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID H1-6 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID MIB2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
RIPK1 BioGRID ZBP1 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID CACYBP GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID CBX5 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID SUGT1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID TAB1 GeneID BioGRID Affinity Capture-MS; Co-fractionation
RIPK1 BioGRID RPA1 GeneID BioGRID Reconstituted Complex
RIPK1 BioGRID PRKN GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
RIPK1 BioGRID PIDD1 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID TRIM72 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
RIPK1 BioGRID RNMT GeneID BioGRID Co-fractionation
RIPK1 BioGRID CUL4A GeneID BioGRID Co-fractionation
RIPK1 BioGRID TRAF2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-fractionation; Co-localization; Reconstituted Complex; Two-hybrid
RIPK1 BioGRID MAP3K7 GeneID BioGRID Affinity Capture-Western; Co-fractionation
RIPK1 BioGRID ALDH1L2 GeneID BioGRID Co-fractionation
RIPK1 BioGRID NT5DC3 GeneID BioGRID Co-fractionation
RIPK1 BioGRID TPRKB GeneID BioGRID Co-fractionation
RIPK1 BioGRID RBCK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
RIPK1 BioGRID RXRA GeneID BioGRID Co-fractionation
RIPK1 BioGRID SMAD3 GeneID BioGRID Co-fractionation
RIPK1 BioGRID ITGB4 GeneID BioGRID Co-fractionation
RIPK1 BioGRID ITGB1 GeneID BioGRID Co-fractionation
RIPK1 BioGRID IKBKB GeneID BioGRID Co-fractionation; Reconstituted Complex
RIPK1 BioGRID DDR1 GeneID BioGRID Co-fractionation
RIPK1 BioGRID RARA GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID PARP1 GeneID BioGRID Proximity Label-MS
RIPK1 BioGRID USP27X GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID ZFP91 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID RIPK3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-localization; PCA; Two-hybrid
RIPK1 BioGRID TRIM28 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID MAP3K14 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID BIRC3 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RIPK1 BioGRID BIRC2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RIPK1 BioGRID IKBKG GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
RIPK1 BioGRID TNFRSF1A GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
RIPK1 BioGRID OTUD1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
RIPK1 BioGRID ANKRD13A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
RIPK1 BioGRID USP21 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
RIPK1 BioGRID BRDT GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID CYLD GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID D2HGDH GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID HERC2P9 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID CCDC96 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID NTAN1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID RCCD1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID DUSP16 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID UBXN6 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID THSD4 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID RTL10 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID INF2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID HSPB8 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID CNOT10 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID EEF1AKMT3 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID ABTB2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID DCTN3 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID NPRL2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID ATG7 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID AP1M2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID RAPGEF5 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID TGM5 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID B4GALT2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID S100A6 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID PSG11 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID PRKY GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID SERPINB6 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID MLF1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID KRT2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID HSPA1A GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID GPX7 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID FGL1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID DHFR GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID UBQLN2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID TNFRSF10B GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID TICAM1 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID PELI1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
RIPK1 BioGRID PRKCZ GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID UL39 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID UL48 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID UL45 GeneID BioGRID Affinity Capture-Western; Co-localization
RIPK1 BioGRID TNFAIP3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization
RIPK1 BioGRID ORF1ab GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID HSCB GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID CIT GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID TPP2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID TAF4 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID SNRPD2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID SNRPD1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID S100A4 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID RPS27A GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID RPS21 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID RP9 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID ABCE1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID P4HB GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID RPSA GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID HSPB1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID PRMT1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID CSNK2A1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID ARGLU1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID MRPS17 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID SRRM2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID SLC4A1AP GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID PHLDA1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID HNRNPR GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID THRAP3 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID USP15 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID BAG2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID RIPK1 GeneID BioGRID Affinity Capture-MS; Biochemical Activity; Two-hybrid
RIPK1 BioGRID CSNK2A3 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID MRPS6 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID CCAR2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID NHLRC2 GeneID BioGRID Proximity Label-MS
RIPK1 BioGRID TRADD GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
RIPK1 BioGRID TRAF3 GeneID BioGRID Affinity Capture-Western; Two-hybrid
RIPK1 BioGRID TRAF1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
RIPK1 BioGRID TNFSF10 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID ATG5 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID MTDH GeneID BioGRID Protein-RNA
RIPK1 BioGRID TBK1 GeneID BioGRID Biochemical Activity
RIPK1 BioGRID IKBKE GeneID BioGRID Biochemical Activity
RIPK1 BioGRID TNIP2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID USP20 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
RIPK1 BioGRID COX5A GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID TRAF5 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
RIPK1 BioGRID LMP-1 GeneID BioGRID Affinity Capture-Western; Co-localization
RIPK1 BioGRID RNF31 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
RIPK1 BioGRID CHUK GeneID BioGRID Affinity Capture-MS; Co-fractionation
RIPK1 BioGRID CBL GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID XIAP GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
RIPK1 BioGRID TAB2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
RIPK1 BioGRID USP1 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID ANXA1 GeneID BioGRID Affinity Capture-Western; Co-fractionation
RIPK1 BioGRID E7 GeneID BioGRID PCA
RIPK1 BioGRID E6 GeneID BioGRID PCA
RIPK1 BioGRID WDR48 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID ANGPTL8 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID EGLN3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
RIPK1 BioGRID XAF1 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID UBC GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID MLKL GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID RNF216 GeneID BioGRID Affinity Capture-Western; Two-hybrid
RIPK1 BioGRID OPTN GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
RIPK1 BioGRID TLR3 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID TRIM27 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID CFLAR GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID USP2 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RIPK1 BioGRID ERN1 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID HERC2 GeneID BioGRID Affinity Capture-MS
RIPK1 BioGRID PYCARD GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID UBE2N GeneID BioGRID Biochemical Activity
RIPK1 BioGRID RFFL GeneID BioGRID Affinity Capture-Western; Biochemical Activity
RIPK1 BioGRID YOD1 GeneID BioGRID Biochemical Activity
RIPK1 BioGRID BMH1 GeneID BioGRID Reconstituted Complex
RIPK1 BioGRID MAP3K8 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID NUMBL GeneID BioGRID Two-hybrid
RIPK1 BioGRID HSP90AA1 GeneID BioGRID Affinity Capture-Luminescence; Affinity Capture-Western
RIPK1 BioGRID USP4 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID LRRK2 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID MAP3K3 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID HHV8GK18_gp80 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID DAB2IP GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID TNFRSF1B GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID CCDC50 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID CLIP3 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID TAX1BP1 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID NOD2 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID RIPK2 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID TNFRSF25 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID KHDRBS1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
RIPK1 BioGRID CDC42BPB GeneID BioGRID Two-hybrid
RIPK1 Protein TRIM38 GeneID HPRD
RIPK1 Protein RNF216 GeneID HPRD
RIPK1 Protein RIPK3 GeneID HPRD
RIPK1 Protein TRPC4AP GeneID HPRD
RIPK1 Protein TICAM1 GeneID HPRD
RIPK1 Protein ZFAND5 GeneID HPRD
RIPK1 Protein MAP3K14 GeneID HPRD
RIPK1 Protein TNFRSF10B GeneID HPRD
RIPK1 Protein TNFRSF10A GeneID HPRD
RIPK1 Protein CFLAR GeneID HPRD
RIPK1 Protein TRADD GeneID HPRD
RIPK1 Protein CRADD GeneID HPRD
RIPK1 Protein RIPK1 GeneID HPRD
RIPK1 Protein MAP3K3 GeneID HPRD
RIPK1 Protein FADD GeneID HPRD
RIPK1 Protein TRAF5 GeneID HPRD
RIPK1 Protein TRAF3 GeneID HPRD
RIPK1 Protein TRAF2 GeneID HPRD
RIPK1 Protein CASP8 GeneID HPRD
RIPK1 Protein TRAF1 GeneID HPRD
RIPK1 Protein SQSTM1 GeneID HPRD
RIPK1 Protein PTK2 GeneID HPRD
RIPK1 Protein IKBKG GeneID HPRD
RIPK1 Protein MAP3K8 GeneID HPRD
RIPK1 Protein TNFRSF1A GeneID HPRD
RIPK1 Protein TNFAIP3 GeneID HPRD
RIPK1 Protein NFKB1 GeneID HPRD
RIPK1 Protein HSP90AA1 GeneID HPRD
RIPK1 Protein FAS GeneID HPRD
RIPK1 Protein EGFR GeneID HPRD
RIPK1 BioGRID ITCH GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID RNF11 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID CRADD GeneID BioGRID Reconstituted Complex
RIPK1 BioGRID EGFR GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID CASP10 GeneID BioGRID Affinity Capture-Western
RIPK1 BioGRID FAS GeneID BioGRID Two-hybrid
RIPK1 BioGRID TRPC4AP GeneID BioGRID Affinity Capture-Western
RIPK1 Protein TRAF2 GeneID BIND TRAF2 interacts with RIP.
RIPK1 Protein ZFAND5 GeneID BIND ZNF216 interacts with RIP.
RIPK1 Protein PTK2 GeneID BIND FAK interacts with RIP.
RIPK1 Protein HHV8gp76 GeneID BIND ORF-K13 from human herpesvirus 8 interacts with human RIP.
RIPK1 Protein TNFAIP3 GeneID BIND A20 ubiquitinates and de-ubiquitinates RIP.
RIPK1 Protein TRAF2 GeneID BIND TRAF2 ubiquitinates RIP.
RIPK1 Protein ORF75 GeneID BIND E8 from Equine herpesvirus 2 interacts with human RIP.
RIPK1 Protein MC159L GeneID BIND MC159L from Molluscum contagiosum virus interacts with human RIP.
StringDB
A B experiments database textmining combined score hadb nhadb
RIPK1 ACTG1 94 0 113 204 1 1
RIPK1 TRAT1 0 0 202 202 1 1
RIPK1 ATG7 130 0 405 491 1 2
RIPK1 CXCL2 0 0 167 167 1 1
RIPK1 EFNB2 0 0 0 168 1 1
RIPK1 FMN1 0 0 0 175 1 1
RIPK1 TUBGCP2 0 0 0 157 1 1
RIPK1 ATM 0 0 559 576 1 2
RIPK1 PLEKHG4B 0 0 0 184 1 1
RIPK1 CTSD 0 0 193 233 1 2
RIPK1 BPHL 0 0 0 547 1 1
RIPK1 GNAI1 0 0 0 177 1 1
RIPK1 ENSG00000267261 0 0 0 178 1 1
RIPK1 BAZ2B 0 0 0 152 1 1
RIPK1 OR8B4 0 0 128 243 1 1
RIPK1 RET 0 0 63 174 1 1
RIPK1 PARP16 0 0 0 208 1 1
RIPK1 NFKBIA 0 650 604 867 1 2
RIPK1 MAP3K3 270 900 712 951 1 1
RIPK1 CLIC4 0 0 0 150 1 1
RIPK1 ATAD2B 0 0 0 170 1 1
RIPK1 ZC3H12A 0 0 155 214 1 1
RIPK1 UBA52 0 900 0 902 1 1
RIPK1 MAPK10 0 0 97 167 1 2
RIPK1 RASAL2 0 0 327 342 1 1
RIPK1 MAPK14 0 900 261 920 1 2
RIPK1 NEK7 0 0 218 231 1 1
RIPK1 PTEN 0 0 243 303 1 2
RIPK1 VEGFA 0 0 206 206 1 2
RIPK1 GABARAP 0 0 113 170 1 2
RIPK1 MAPK7 0 0 107 189 1 1
RIPK1 STXBP5L 0 0 0 158 1 1
RIPK1 PRKAA2 0 0 0 158 1 2
RIPK1 WIPI1 0 0 90 168 1 2
RIPK1 TRAF7 0 0 325 418 1 1
RIPK1 CASP5 0 0 260 351 1 1
RIPK1 DNM1L 0 800 454 888 1 2
RIPK1 RPS6KL1 0 0 0 155 1 1
RIPK1 TLR8 0 0 323 370 1 1
RIPK1 ATG5 270 0 580 714 1 2
RIPK1 MAP2K6 0 900 119 907 1 1
RIPK1 WNT3A 0 0 66 204 1 2
RIPK1 STAT2 0 0 192 296 1 1
RIPK1 XBP1 0 0 234 270 1 2
RIPK1 ELF4 0 0 0 150 1 1
RIPK1 SIRT1 0 0 217 217 1 2
RIPK1 MCL1 0 0 392 405 1 2
RIPK1 NOX1 0 0 451 488 1 1
RIPK1 SPAG1 0 0 0 220 1 1
RIPK1 CTSB 0 0 282 295 1 2
RIPK1 DPM1 0 0 0 153 1 1
RIPK1 COPS5 0 0 181 195 1 1
RIPK1 MAPK6 0 0 75 177 1 1
RIPK1 RAC1 0 0 94 187 1 2
RIPK1 HMGB1 0 0 458 467 1 2
RIPK1 IRF5 0 0 261 289 1 1
RIPK1 PPP1CA 0 0 81 186 1 1
RIPK1 MAP3K5 0 900 607 936 1 1
RIPK1 GNA11 0 0 66 180 1 1
RIPK1 ITGAM 0 0 264 290 1 1
RIPK1 RPS6KA1 0 0 108 161 1 1
RIPK1 OTUD1 270 0 95 326 1 1
RIPK1 MAP3K12 0 0 561 339 1 1
RIPK1 NEK2 0 0 45 152 1 1
RIPK1 DEDD2 0 0 122 256 1 1
RIPK1 PARD6B 0 0 0 189 1 1
RIPK1 MAP4K4 0 900 66 909 1 1
RIPK1 IKBKG 913 900 989 999 1 1
RIPK1 URGCP 0 0 398 398 1 1
RIPK1 HSPB1 117 0 144 233 1 2
RIPK1 USP18 0 0 164 214 1 1
RIPK1 ATG10 0 0 167 167 1 2
RIPK1 NFKBIB 0 650 262 760 1 1
RIPK1 ADAM17 0 0 202 202 1 1
RIPK1 DUSP14 0 0 61 162 1 1
RIPK1 MAMDC4 0 0 0 190 1 1
RIPK1 ISG15 0 0 218 283 1 2
RIPK1 DFFB 0 0 324 323 1 1
RIPK1 PTPN11 0 0 101 184 1 1
RIPK1 IRAK3 0 0 284 189 1 1
RIPK1 IRG1 0 0 102 159 1 1
RIPK1 APCDD1 0 0 0 189 1 1
RIPK1 FOS 0 0 208 231 1 2
RIPK1 PPM1N 0 0 0 198 1 1
RIPK1 YWHAZ 0 0 0 165 1 1
RIPK1 CCDC127 0 0 85 177 1 1
RIPK1 SOD2 0 0 155 185 1 2
RIPK1 FOXO1 0 0 143 234 1 2
RIPK1 DUSP3 0 0 63 164 1 1
RIPK1 MYO3B 0 0 71 197 1 1
RIPK1 BTRC 0 0 211 281 1 1
RIPK1 FTH1 0 0 150 194 1 1
RIPK1 HSPA5 118 0 254 409 1 2
RIPK1 CASP14 0 0 166 185 1 1
RIPK1 NRAS 0 0 69 168 1 1
RIPK1 MET 0 0 62 188 1 2
RIPK1 TRAF3 406 900 668 980 1 2
RIPK1 LRRK2 270 0 285 436 1 2
RIPK1 GNAO1 0 0 0 177 1 1
RIPK1 TOLLIP 0 0 242 270 1 1
RIPK1 PMAIP1 0 0 326 325 1 2
RIPK1 PIK3CB 0 0 0 183 1 1
RIPK1 TLR2 0 0 452 490 1 2
RIPK1 PIM3 0 0 0 181 1 1
RIPK1 PRKCH 0 0 0 167 1 1
RIPK1 ANKRD45 0 0 0 175 1 1
RIPK1 ZMYND11 0 0 0 157 1 1
RIPK1 EIF4EBP2 0 0 0 278 1 1
RIPK1 OTUD7B 0 900 391 938 1 1
RIPK1 CLIC1 0 0 0 150 1 1
RIPK1 GNAI3 0 0 0 177 1 2
RIPK1 NOD1 0 0 378 400 1 2
RIPK1 GRID2 0 0 0 150 1 2
RIPK1 MALRD1 0 0 0 190 1 1
RIPK1 UGP2 0 0 0 162 1 1
RIPK1 DNAJB9 0 0 56 157 1 2
RIPK1 SHARPIN 0 800 637 927 1 1
RIPK1 TBKBP1 0 0 210 222 1 1
RIPK1 CD86 0 0 180 179 1 1
RIPK1 PARP2 0 0 130 153 1 1
RIPK1 DAXX 270 0 193 396 1 1
RIPK1 TNFRSF21 0 0 284 284 1 1
RIPK1 LNX1 0 0 0 200 1 1
RIPK1 RPS6KC1 0 0 0 204 1 1
RIPK1 GNA15 0 0 60 175 1 1
RIPK1 CXCL1 0 0 283 282 1 2
RIPK1 IL33 0 0 292 292 1 2
RIPK1 TRIB3 0 0 0 177 1 2
RIPK1 DIRAS3 0 0 0 178 1 2
RIPK1 EBF3 0 0 0 155 1 1
RIPK1 PPIA 0 0 149 164 1 1
RIPK1 TRIM56 0 0 109 153 1 1
RIPK1 CD28 0 0 182 194 1 1
RIPK1 PRKCQ 0 0 90 225 1 2
RIPK1 ATG12 0 0 303 317 1 2
RIPK1 USP11 0 0 214 231 1 2
RIPK1 CUL3 0 0 213 282 1 2
RIPK1 CHUK 487 900 723 965 1 1
RIPK1 NLRP11 0 0 90 255 1 1
RIPK1 SAMHD1 0 0 101 171 1 1
RIPK1 WNT2 0 0 45 188 1 1
RIPK1 SLC11A1 0 0 0 182 1 1
RIPK1 ITGAX 0 0 167 214 1 1
RIPK1 STAMBPL1 0 0 128 158 1 1
RIPK1 CASP4 0 0 212 324 1 2
RIPK1 SFN 0 0 0 165 1 2
RIPK1 HDAC1 0 0 130 163 1 2
RIPK1 EGFLAM 0 0 0 155 1 1
RIPK1 CSF1 0 0 181 231 1 1
RIPK1 YWHAH 0 0 0 165 1 1
RIPK1 PHB2 0 0 135 185 1 1
RIPK1 AP1M2 160 0 0 179 1 1
RIPK1 PI4KA 0 0 0 182 1 1
RIPK1 ZNF18 0 0 88 223 1 1
RIPK1 ATG3 0 0 282 335 1 2
RIPK1 BIRC6 0 0 211 311 1 1
RIPK1 PXK 0 0 53 153 1 1
RIPK1 CDKN3 0 0 77 150 1 1
RIPK1 TLR3 486 600 807 960 1 2
RIPK1 CORO1A 0 0 0 162 1 1
RIPK1 TAF4 117 0 0 150 1 1
RIPK1 RNPEPL1 0 0 0 153 1 1
RIPK1 TNFSF11 0 0 181 181 1 2
RIPK1 VDAC3 0 0 157 173 1 1
RIPK1 NEK1 0 0 459 341 1 1
RIPK1 FOXO3 0 0 183 248 1 2
RIPK1 BBOX1 0 0 167 167 1 1
RIPK1 UAP1L1 0 0 0 169 1 1
RIPK1 RAG1 0 0 81 150 1 1
RIPK1 CDC42 0 0 129 218 1 2
RIPK1 GLUL 0 0 234 260 1 1
RIPK1 ALG2 0 0 0 157 1 1
RIPK1 VDAC1 0 0 212 227 1 2
RIPK1 TGFB1 0 0 75 203 1 2
RIPK1 RAB7B 0 0 120 174 1 1
RIPK1 LRIT3 0 0 0 165 1 1
RIPK1 STAT5B 0 0 114 211 1 1
RIPK1 RIPK3 981 800 990 997 1 2
RIPK1 PRKCD 0 0 172 241 1 2
RIPK1 MAP3K6 0 0 81 242 1 1
RIPK1 NKX1-2 0 0 61 324 1 1
RIPK1 USP7 0 0 255 284 1 1
RIPK1 FOXP3 0 0 148 216 1 2
RIPK1 YTHDC2 0 0 0 150 1 1
RIPK1 PTPN6 0 0 183 258 1 1
RIPK1 POP4 0 0 0 171 1 1
RIPK1 ATG2B 0 0 113 153 1 2
RIPK1 TBK1 678 0 803 935 1 2
RIPK1 CORO2A 0 0 0 162 1 1
RIPK1 RAC2 0 0 48 153 1 1
RIPK1 PARD6G 0 0 0 189 1 1
RIPK1 SKP1 0 0 210 240 1 2
RIPK1 ATP7A 0 0 46 157 1 1
RIPK1 ENSG00000279392 0 0 150 193 1 1
RIPK1 NLRC4 0 0 358 358 1 2
RIPK1 NOX4 0 0 134 173 1 2
RIPK1 RNF216 675 0 539 847 1 1
RIPK1 NADK 0 0 49 165 1 1
RIPK1 PARL 0 0 70 167 1 1
RIPK1 WEE2 0 0 57 177 1 1
RIPK1 TRAPPC12 0 0 66 279 1 1
RIPK1 GRIK1 0 0 0 150 1 1
RIPK1 EFNB3 0 0 0 168 1 1
RIPK1 CSF2 0 0 252 252 1 1
RIPK1 CIRBP 0 0 103 200 1 1
RIPK1 FAS 476 900 734 985 1 2
RIPK1 VCAM1 0 0 160 159 1 1
RIPK1 MAP3K15 0 0 0 168 1 1
RIPK1 WDTC1 0 0 0 164 1 1
RIPK1 INPP5D 0 0 142 155 1 1
RIPK1 AIFM1 0 0 82 275 1 1
RIPK1 CARD6 270 0 607 705 1 1
RIPK1 PPM1E 0 0 0 206 1 1
RIPK1 CSNK2A3 117 0 0 213 1 1
RIPK1 DENR 0 0 181 211 1 1
RIPK1 C9orf89 0 0 90 230 1 1
RIPK1 MYOF 0 0 334 364 1 1
RIPK1 PHGDH 0 0 123 163 1 1
RIPK1 GPT 0 0 209 239 1 1
RIPK1 PUS10 0 0 49 198 1 1
RIPK1 UBQLN1 0 0 81 171 1 1
RIPK1 PINK1 0 0 252 283 1 2
RIPK1 GRIK4 0 0 0 150 1 1
RIPK1 HSP90AB1 129 800 66 914 1 2
RIPK1 DDX56 0 0 124 159 1 1
RIPK1 ADRM1 0 0 97 206 1 1
RIPK1 CYLD 835 900 841 997 1 1
RIPK1 PHF20 0 0 310 330 1 1
RIPK1 CCT2 0 0 0 159 1 1
RIPK1 WDFY3 0 0 59 151 1 2
RIPK1 MAPK1 0 0 203 219 1 2
RIPK1 IGF1 0 0 339 339 1 2
RIPK1 SOCS1 0 0 202 276 1 1
RIPK1 RNF41 0 0 96 207 1 1
RIPK1 NEDD4L 0 0 54 170 1 1
RIPK1 EFNA3 0 0 0 168 1 1
RIPK1 IFNAR1 0 0 509 594 1 1
RIPK1 IREB2 0 0 298 329 1 1
RIPK1 PPTC7 0 0 0 198 1 1
RIPK1 PPEF2 0 0 0 154 1 1
RIPK1 RELB 0 0 459 477 1 2
RIPK1 TNFSF14 0 0 108 162 1 1
RIPK1 BCL2A1 0 0 184 183 1 1
RIPK1 BAG4 0 900 158 913 1 1
RIPK1 ABI2 0 0 0 150 1 1
RIPK1 NRIP1 0 0 310 309 1 1
RIPK1 TSSK1B 0 0 0 158 1 1
RIPK1 DDX3X 0 0 137 153 1 1
RIPK1 TANK 0 900 768 979 1 2
RIPK1 SDK2 0 0 0 171 1 1
RIPK1 TIRAP 0 0 457 477 1 1
RIPK1 HSPA2 0 0 0 192 1 1
RIPK1 C19orf80 270 0 0 270 1 1
RIPK1 BDNF 0 0 119 170 1 2
RIPK1 GNAI2 0 0 0 177 1 1
RIPK1 CASP2 0 900 648 964 1 1
RIPK1 TXN 0 0 157 196 1 1
RIPK1 CCNE1 0 0 0 183 1 1
RIPK1 NDUFA13 0 0 454 454 1 1
RIPK1 ENSG00000258973 0 0 0 278 1 1
RIPK1 THSD4 482 0 0 490 1 1
RIPK1 GRIK5 0 0 0 150 1 1
RIPK1 INADL 0 0 0 159 1 1
RIPK1 UBB 0 900 95 916 1 1
RIPK1 CENPK 0 0 0 157 1 1
RIPK1 TSSK2 0 0 0 158 1 1
RIPK1 DFFA 0 0 202 202 1 1
RIPK1 GNB2L1 0 900 46 902 1 1
RIPK1 LPCAT3 0 0 120 164 1 1
RIPK1 PSMA7 0 0 108 159 1 1
RIPK1 EFNA1 0 0 0 168 1 1
RIPK1 UAP1 0 0 0 169 1 1
RIPK1 EVL 0 0 0 158 1 1
RIPK1 RHEB 0 0 92 188 1 2
RIPK1 MAP2K2 0 0 74 195 1 1
RIPK1 PHLPP2 0 0 44 164 1 1
RIPK1 IRAK2 0 0 450 453 1 1
RIPK1 GRAMD4 0 0 193 205 1 1
RIPK1 TNFRSF10D 0 0 325 423 1 1
RIPK1 CCND1 0 0 209 209 1 2
RIPK1 LRGUK 0 0 0 161 1 1
RIPK1 PRKAA1 0 0 60 165 1 2
RIPK1 PPM1K 0 0 0 198 1 1
RIPK1 YWHAQ 0 0 0 165 1 1
RIPK1 KAT2B 0 0 73 155 1 1
RIPK1 BAD 0 0 142 213 1 2
RIPK1 PRKDC 0 0 75 163 1 2
RIPK1 PPP2CA 0 0 63 170 1 1
RIPK1 EIF4E 0 0 103 184 1 2
RIPK1 IFT43 0 0 292 292 1 1
RIPK1 TRADD 872 900 989 999 1 1
RIPK1 ALK 0 0 72 189 1 2
RIPK1 ZYX 0 0 0 190 1 1
RIPK1 MB21D1 0 0 293 293 1 1
RIPK1 PRKCZ 0 900 138 904 1 1
RIPK1 CDH1 0 0 136 162 1 2
RIPK1 PGGT1B 0 0 67 155 1 1
RIPK1 VPS35 0 0 0 171 1 2
RIPK1 OR2L13 0 0 71 263 1 1
RIPK1 SGK494 0 0 0 195 1 1
RIPK1 DDX41 0 0 125 358 1 1
RIPK1 AGER 0 0 167 186 1 2
RIPK1 BIRC3 755 900 930 998 1 1
RIPK1 ANXA8 0 0 232 231 1 1
RIPK1 SMAD3 0 0 95 157 1 2
RIPK1 IL4 0 0 210 210 1 1
RIPK1 EP300 0 0 122 200 1 2
RIPK1 LEF1 0 0 81 151 1 1
RIPK1 NUMB 0 0 0 178 1 1
RIPK1 CSNK1D 0 0 0 164 1 1
RIPK1 CUL1 0 0 161 238 1 1
RIPK1 CASP7 0 0 460 483 1 1
RIPK1 NUP62CL 0 0 127 244 1 1
RIPK1 ALB 0 0 263 263 1 2
RIPK1 CD68 0 0 108 158 1 2
RIPK1 CDC37 130 0 258 358 1 1
RIPK1 CCL2 0 0 326 325 1 2
RIPK1 OTULIN 0 0 542 552 1 1
RIPK1 IDO1 0 0 156 175 1 1
RIPK1 PDCD4 0 0 115 156 1 2
RIPK1 CYP2E1 0 0 156 169 1 2
RIPK1 HSP90B1 0 0 91 288 1 1
RIPK1 PYDC1 0 0 46 163 1 1
RIPK1 DICER1 0 0 108 163 1 1
RIPK1 PDZD2 0 0 0 159 1 1
RIPK1 PCBP2 0 0 95 153 1 1
RIPK1 HSPA4 0 0 218 295 1 1
RIPK1 TRPC4AP 270 0 0 270 1 1
RIPK1 GAK 0 0 0 152 1 1
RIPK1 PELI1 270 800 294 900 1 1
RIPK1 PCSK1 0 0 901 906 1 1
RIPK1 GNAZ 0 0 0 177 1 1
RIPK1 EPS15L1 0 0 0 228 1 1
RIPK1 BMP2 0 0 60 166 1 1
RIPK1 EGF 0 0 181 193 1 2
RIPK1 DUSP12 0 0 66 166 1 1
RIPK1 CYCS 0 0 518 518 1 2
RIPK1 DHX36 0 0 87 260 1 1
RIPK1 PDP1 0 0 0 201 1 1
RIPK1 CXCL11 0 0 113 174 1 1
RIPK1 PPM1L 0 0 0 198 1 1
RIPK1 TRAF6 0 900 945 995 1 2
RIPK1 COLGALT1 0 0 177 177 1 1
RIPK1 CLIC2 0 0 0 150 1 1
RIPK1 MAP2K4 0 900 232 911 1 1
RIPK1 MAPK8 0 0 583 354 1 2
RIPK1 KLRD1 0 0 0 155 1 1
RIPK1 PTK2 213 0 103 266 1 2
RIPK1 CHKA 0 0 0 159 1 1
RIPK1 PPP2CB 0 0 0 151 1 1
RIPK1 P2RX7 0 0 157 163 1 2
RIPK1 BAZ1B 0 0 74 156 1 1
RIPK1 SPATA2 0 0 392 392 1 1
RIPK1 DIABLO 0 0 710 717 1 2
RIPK1 GPX4 0 0 395 408 1 2
RIPK1 MAPRE3 0 0 0 155 1 1
RIPK1 TMC8 0 0 300 300 1 1
RIPK1 TPP2 117 0 0 151 1 1
RIPK1 ANKHD1 0 0 0 152 1 1
RIPK1 LTA 270 900 140 963 1 1
RIPK1 SOD1 0 0 207 249 1 2
RIPK1 PP2D1 0 0 0 198 1 1
RIPK1 GRB2 0 0 123 241 1 1
RIPK1 EYS 0 0 0 181 1 1
RIPK1 NFKBIE 0 0 301 483 1 1
RIPK1 LRIT1 0 0 0 165 1 1
RIPK1 ABI1 0 0 0 150 1 1
RIPK1 ENSG00000270024 0 0 0 196 1 1
RIPK1 TNFRSF13C 0 0 203 203 1 1
RIPK1 PPM1F 0 0 0 198 1 1
RIPK1 CLIP4 0 0 0 163 1 1
RIPK1 MFN1 0 0 141 175 1 2
RIPK1 EIF2AK2 0 800 157 822 1 2
RIPK1 PIK3CG 0 0 108 200 1 1
RIPK1 PADI4 0 0 161 161 1 1
RIPK1 STXBP5 0 0 0 158 1 1
RIPK1 OR1L8 0 0 139 152 1 1
RIPK1 AIF1 0 0 194 246 1 2
RIPK1 MYO3A 0 0 0 156 1 1
RIPK1 DNTT 0 0 265 265 1 1
RIPK1 TRIM38 270 0 112 335 1 1
RIPK1 CLIC5 0 0 0 150 1 1
RIPK1 JUN 0 0 467 487 1 2
RIPK1 DHX15 0 0 54 250 1 1
RIPK1 ETNK2 0 0 0 159 1 1
RIPK1 CORO2B 0 0 0 162 1 1
RIPK1 TRIO 0 0 0 167 1 1
RIPK1 ENSG00000173366 0 0 404 450 1 1
RIPK1 DIDO1 0 0 0 182 1 1
RIPK1 SET 0 0 209 220 1 1
RIPK1 RFFL 270 900 0 923 1 1
RIPK1 HSP90AA1 637 800 918 994 1 2
RIPK1 BCL3 0 0 138 285 1 1
RIPK1 MMP9 0 0 195 195 1 2
RIPK1 MAPK3 0 0 686 389 1 2
RIPK1 SQSTM1 486 900 836 991 1 2
RIPK1 BNIP3 0 0 195 195 1 2
RIPK1 SLC11A2 0 0 45 186 1 1
RIPK1 USP17L2 0 0 104 150 1 1
RIPK1 GNA14 0 0 0 158 1 1
RIPK1 ATG13 0 0 185 185 1 2
RIPK1 NLRX1 0 0 182 264 1 2
RIPK1 GRAP2 0 0 66 192 1 1
RIPK1 AURKA 0 0 407 221 1 2
RIPK1 GNA12 0 0 0 177 1 1
RIPK1 N4BP1 0 0 122 309 1 1
RIPK1 BAX 0 0 320 319 1 2
RIPK1 IFNAR2 0 0 166 165 1 1
RIPK1 BID 0 900 365 933 1 2
RIPK1 RNF8 0 0 61 255 1 1
RIPK1 ZNF711 0 0 282 311 1 1
RIPK1 IGDCC3 0 0 0 184 1 1
RIPK1 ICAM1 0 0 233 252 1 2
RIPK1 RALB 0 0 67 182 1 2
RIPK1 BCL10 0 0 391 491 1 1
RIPK1 SMDT1 0 0 361 361 1 1
RIPK1 WDR48 270 0 95 371 1 1
RIPK1 HUNK 0 0 0 158 1 1
RIPK1 PTPRC 0 0 217 265 1 1
RIPK1 GZMB 0 0 143 209 1 1
RIPK1 STAT1 0 900 422 947 1 2
RIPK1 RIC3 0 0 57 272 1 1
RIPK1 ENDOG 0 0 330 334 1 1
RIPK1 BCL2L2-PABPN1 0 0 166 184 1 1
RIPK1 GNA13 0 0 0 177 1 1
RIPK1 PIK3C3 0 0 289 418 1 2
RIPK1 MAPRE1 0 0 0 157 1 1
RIPK1 TRIB2 0 0 0 162 1 1
RIPK1 MTOR 0 0 294 361 1 2
RIPK1 RRAS 0 0 0 168 1 1
RIPK1 USP21 270 800 538 927 1 1
RIPK1 IKBKE 678 0 342 750 1 1
RIPK1 IGSF9B 0 0 0 156 1 1
RIPK1 ATE1 0 0 120 588 1 1
RIPK1 PASK 0 0 0 158 1 1
RIPK1 WNT2B 0 0 0 185 1 1
RIPK1 ALG1 0 0 0 157 1 1
RIPK1 RANBP17 0 0 0 165 1 1
RIPK1 MFN2 0 0 141 175 1 2
RIPK1 ARL8A 0 0 0 151 1 1
RIPK1 APP 0 0 157 171 1 2
RIPK1 DCAF6 0 0 0 164 1 1
RIPK1 RBM5 0 0 72 169 1 1
RIPK1 CTNNB1 0 0 212 319 1 2
RIPK1 ENSG00000258989 0 0 0 173 1 1
RIPK1 HRAS 0 0 218 301 1 2
RIPK1 NFKBID 0 0 151 220 1 1
RIPK1 POLR2C 0 0 0 154 1 1
RIPK1 CXCL8 0 0 374 374 1 2
RIPK1 VRK1 0 0 0 164 1 1
RIPK1 SMPD3 0 900 0 900 1 1
RIPK1 NEDD4 0 0 155 258 1 2
RIPK1 TRIM27 270 0 202 402 1 1
RIPK1 BAG3 0 0 58 156 1 2
RIPK1 EBF1 0 0 0 155 1 1
RIPK1 MAP2K7 0 900 250 917 1 1
RIPK1 TSSK3 0 0 0 157 1 1
RIPK1 PELI2 0 0 49 247 1 1
RIPK1 TNFSF15 0 0 128 161 1 1
RIPK1 SMG1 0 0 66 155 1 1
RIPK1 GAPDH 0 800 456 890 1 2
RIPK1 ALG1L 0 0 0 157 1 1
RIPK1 DUSP5 0 0 95 192 1 1
RIPK1 SPSB1 0 0 51 183 1 1
RIPK1 HTR3A 0 0 0 271 1 1
RIPK1 TMED7 0 0 0 151 1 1
RIPK1 RELA 0 900 507 950 1 2
RIPK1 NFKB1 213 900 351 953 1 2
RIPK1 CASP6 0 0 345 360 1 1
RIPK1 STAT4 0 0 49 175 1 1
RIPK1 TLR10 0 0 160 202 1 1
RIPK1 NABP1 0 0 138 213 1 1
RIPK1 TRIM25 0 600 271 708 1 1
RIPK1 SNRPD3 0 0 0 254 1 1
RIPK1 GRID2IP 0 0 0 260 1 1
RIPK1 SIRT2 0 0 302 302 1 2
RIPK1 GRIK2 0 0 0 150 1 1
RIPK1 GSDMD 0 0 556 566 1 2
RIPK1 EFNB1 0 0 0 168 1 1
RIPK1 USP9X 0 0 141 172 1 1
RIPK1 DHX9 0 0 42 162 1 1
RIPK1 APC 0 0 0 178 1 1
RIPK1 KHDRBS1 270 0 444 630 1 1
RIPK1 GZMM 0 0 322 332 1 1
RIPK1 WWP1 0 0 91 248 1 1
RIPK1 CREBBP 0 0 112 191 1 1
RIPK1 PPID 0 0 241 254 1 1
RIPK1 UBE2D3 0 900 217 920 1 1
RIPK1 MAP3K8 270 0 260 424 1 1
RIPK1 ST13 0 0 193 193 1 2
RIPK1 OASL 0 0 48 163 1 1
RIPK1 BRCA1 0 0 144 184 1 2
RIPK1 STK11 0 0 91 175 1 2
RIPK1 DAB2IP 486 0 568 774 1 2
RIPK1 RB1CC1 0 0 242 304 1 2
RIPK1 ALG11 0 0 0 157 1 1
RIPK1 MYL9 0 0 74 150 1 1
RIPK1 ZNF501 0 0 217 249 1 1
RIPK1 CASP10 486 900 694 993 1 1
RIPK1 DDX50 0 0 0 153 1 1
RIPK1 INHBA 0 0 0 208 1 1
RIPK1 FLNA 0 0 60 177 1 1
RIPK1 TNFRSF12A 0 0 305 305 1 1
RIPK1 ACP5 0 0 444 488 1 1
RIPK1 TOP1 0 0 143 182 1 1
RIPK1 GNAQ 0 0 45 162 1 1
RIPK1 WDR64 0 0 0 176 1 1
RIPK1 NTAN1 418 0 0 418 1 1
RIPK1 EGLN3 270 0 61 285 1 1
RIPK1 USP15 270 0 233 428 1 1
RIPK1 TMBIM6 0 0 126 163 1 1
RIPK1 P4HB 117 0 53 168 1 2
RIPK1 MEFV 0 0 369 379 1 1
RIPK1 PIM1 0 0 46 167 1 1
RIPK1 RGS10 0 0 45 156 1 1
RIPK1 ABI3 0 0 0 150 1 1
RIPK1 ROBO4 0 0 0 151 1 1
RIPK1 IFNA1 0 0 369 369 1 1
RIPK1 PARK2 270 0 182 416 1 1
RIPK1 WNT5A 0 0 66 162 1 2
RIPK1 APC2 0 0 0 164 1 1
RIPK1 UCK2 0 0 0 171 1 1
RIPK1 RNF125 0 0 194 195 1 1
RIPK1 PPP5C 0 0 90 180 1 1
RIPK1 CBLB 0 0 0 203 1 1
RIPK1 RHBDL3 0 0 0 166 1 1
RIPK1 CD300C 0 0 209 209 1 1
RIPK1 ETNK1 0 0 0 159 1 1
RIPK1 UBR5 0 0 82 156 1 1
RIPK1 FHOD3 0 0 0 163 1 1
RIPK1 BRD4 0 0 106 200 1 2
RIPK1 HUWE1 0 0 113 166 1 1
RIPK1 MELK 0 0 0 158 1 1
RIPK1 GNAT1 0 0 0 177 1 1
RIPK1 HDAC6 0 0 119 171 1 2
RIPK1 APAF1 0 0 492 540 1 2
RIPK1 NLRC5 0 0 112 206 1 1
RIPK1 TP53RK 0 0 0 196 1 1
RIPK1 C19orf24 0 0 0 168 1 1
RIPK1 ZNF793 0 0 123 247 1 1
RIPK1 NFKBIZ 0 0 150 246 1 1
RIPK1 TNFRSF11B 0 0 146 164 1 1
RIPK1 EDA 0 0 0 295 1 1
RIPK1 MAP1A 0 0 148 227 1 2
RIPK1 ZBP1 747 800 654 981 1 1
RIPK1 MAP3K7 835 900 953 989 1 2
RIPK1 VRK3 0 0 0 164 1 1
RIPK1 FHOD1 0 0 0 182 1 1
RIPK1 CARD9 0 0 218 352 1 1
RIPK1 CUL2 0 0 108 186 1 1
RIPK1 IRAK1 0 0 558 280 1 1
RIPK1 PPP1CC 0 0 63 157 1 1
RIPK1 TNFRSF4 0 0 56 194 1 1
RIPK1 EGFR 270 0 520 471 1 2
RIPK1 CFLAR 753 900 925 998 1 2
RIPK1 MAP3K13 0 0 561 337 1 1
RIPK1 LAMP1 0 0 143 192 1 2
RIPK1 NEDD8 0 0 304 362 1 2
RIPK1 EPS15 0 0 56 293 1 1
RIPK1 TIMM50 96 0 0 170 1 1
RIPK1 TP53 0 0 581 588 1 2
RIPK1 MDM2 0 0 235 263 1 2
RIPK1 OR2AK2 0 0 0 189 1 1
RIPK1 OTUD5 0 0 249 266 1 1
RIPK1 FOXD4L6 0 0 136 205 1 1
RIPK1 CCAR1 0 0 457 469 1 1
RIPK1 IRAK4 0 0 468 238 1 1
RIPK1 CLIP3 270 600 167 740 1 1
RIPK1 IL10 0 0 310 323 1 2
RIPK1 UBE2S 0 0 155 177 1 1
RIPK1 TNFRSF10C 0 0 259 367 1 1
RIPK1 ATP7B 0 0 0 152 1 1
RIPK1 OGT 0 900 0 906 1 2
RIPK1 KIT 0 0 134 159 1 2
RIPK1 NKAP 0 0 641 641 1 1
RIPK1 AMBRA1 0 0 150 169 1 2
RIPK1 GOPC 0 0 0 273 1 2
RIPK1 CORO1B 0 0 0 162 1 1
RIPK1 TSSK6 0 0 0 158 1 1
RIPK1 CLEC4E 0 0 202 216 1 1
RIPK1 DSTYK 0 0 723 340 1 1
RIPK1 SLC9C2 0 0 0 175 1 1
RIPK1 NLRP6 0 0 174 273 1 1
RIPK1 LTA4H 0 0 71 289 1 1
RIPK1 BST2 0 0 413 412 1 1
RIPK1 STK40 0 0 45 187 1 1
RIPK1 ACSL4 0 0 167 199 1 1
RIPK1 NME8 0 0 0 164 1 1
RIPK1 PDCD1LG2 0 0 0 183 1 1
RIPK1 AASDHPPT 0 0 593 593 1 1
RIPK1 BHLHE41 0 0 0 243 1 1
RIPK1 INHA 0 0 0 179 1 1
RIPK1 TRIP6 0 0 60 171 1 1
RIPK1 EDAR 0 0 160 159 1 1
RIPK1 ILKAP 0 0 0 198 1 1
RIPK1 CALCOCO2 0 0 181 204 1 2
RIPK1 HSF4 0 0 0 170 1 1
RIPK1 MIB1 0 0 0 188 1 1
RIPK1 IRF1 0 0 241 271 1 2
RIPK1 SIKE1 0 0 72 170 1 1
RIPK1 UBE2D2 0 900 137 912 1 1
RIPK1 DFNA5 0 0 349 349 1 1
RIPK1 ESR1 0 0 125 157 1 2
RIPK1 PIM2 0 0 89 204 1 1
RIPK1 CHKB 0 0 0 159 1 1
RIPK1 IFNB1 0 0 959 959 1 1
RIPK1 OPTN 835 0 531 920 1 2
RIPK1 PDK4 0 0 0 197 1 1
RIPK1 RIPK4 0 0 310 258 1 1
RIPK1 ULK1 0 0 338 199 1 2
RIPK1 CDC25B 0 0 0 256 1 1
RIPK1 PKN1 0 0 66 175 1 1
RIPK1 ELANE 0 0 146 159 1 1
RIPK1 SPRED2 0 0 45 161 1 2
RIPK1 GRIP2 0 0 0 151 1 1
RIPK1 MST1R 0 0 0 181 1 1
RIPK1 SPHK1 0 0 328 338 1 2
RIPK1 EFNA2 0 0 0 168 1 1
RIPK1 EIF2A 0 0 66 639 1 2
RIPK1 UBC 675 900 128 972 1 2
RIPK1 MAP1LC3B 0 0 323 368 1 2
RIPK1 SPHK2 0 0 156 169 1 1
RIPK1 PIGA 0 0 0 157 1 1
RIPK1 TNIP1 0 0 334 439 1 1
RIPK1 FAF1 0 800 112 827 1 1
RIPK1 XAF1 270 0 154 370 1 1
RIPK1 TNIP2 192 0 284 411 1 1
RIPK1 BIRC7 0 0 289 344 1 1
RIPK1 STAT5A 0 0 113 230 1 1
RIPK1 RHOD 0 0 61 157 1 1
RIPK1 MNDA 0 0 52 151 1 1
RIPK1 SOCS3 0 0 113 191 1 1
RIPK1 FASLG 0 900 659 964 1 1
RIPK1 CORO1C 0 0 0 162 1 1
RIPK1 TSSK4 0 0 0 158 1 1
RIPK1 KRAS 0 0 184 285 1 2
RIPK1 PKN2 0 0 113 169 1 1
RIPK1 SNRNP200 0 0 0 233 1 1
RIPK1 HAX1 0 0 113 202 1 1
RIPK1 KIAA1614 0 0 0 189 1 1
RIPK1 CHRNB4 0 0 0 156 1 1
RIPK1 PPM1A 0 0 74 228 1 1
RIPK1 HSH2D 0 0 233 232 1 1
RIPK1 NCAPD2 0 0 0 177 1 1
RIPK1 DNAJC10 0 0 0 166 1 1
RIPK1 DUSP1 0 0 124 218 1 1
RIPK1 MAPK11 0 0 123 191 1 1
RIPK1 IL2 0 0 182 181 1 1
RIPK1 TLR6 0 0 253 312 1 1
RIPK1 GYS1 0 0 0 157 1 1
RIPK1 ANXA1 486 0 100 533 1 1
RIPK1 FBXL19 0 0 0 194 1 1
RIPK1 KANK2 0 0 216 280 1 1
RIPK1 MAPT 0 0 74 172 1 2
RIPK1 BECN1 0 0 455 486 1 2
RIPK1 EEF1G 0 0 0 195 1 1
RIPK1 IKBIP 0 0 59 158 1 1
RIPK1 CARD11 0 0 296 442 1 1
RIPK1 ZNF684 0 0 122 227 1 1
RIPK1 CDC25A 0 0 89 211 1 1
RIPK1 USP20 270 0 148 365 1 1
RIPK1 ENSG00000251246 0 0 0 168 1 1
RIPK1 PTGS2 0 0 193 239 1 2
RIPK1 SMURF1 0 0 92 203 1 1
RIPK1 CASP3 0 900 681 967 1 2
RIPK1 DHX29 0 0 0 153 1 1
RIPK1 LTK 0 0 0 177 1 1
RIPK1 REL 0 0 425 483 1 2
RIPK1 ATG101 0 0 150 227 1 2
RIPK1 NLRP3 0 0 520 537 1 2
RIPK1 NCAPH 0 0 0 178 1 1
RIPK1 UBE2V1 0 900 332 930 1 1
RIPK1 MAPK15 0 0 0 164 1 1
RIPK1 NEK4 0 0 0 155 1 1
RIPK1 RAD21 0 0 0 256 1 1
RIPK1 CYBB 0 0 234 284 1 2
RIPK1 TNFRSF10B 486 900 532 977 1 2
RIPK1 PPM1B 0 0 336 469 1 1
RIPK1 TNFSF13B 0 0 202 286 1 1
RIPK1 INSRR 0 0 0 186 1 1
RIPK1 NPLOC4 0 0 427 439 1 1
RIPK1 GSK3B 0 0 322 241 1 2
RIPK1 PPP6C 0 0 94 200 1 1
RIPK1 CDKN2A 0 0 162 231 1 2
RIPK1 RPS27A 454 900 81 949 1 1
RIPK1 LTBR 0 0 261 277 1 1
RIPK1 CEBPB 0 0 120 163 1 2
RIPK1 SMPD1 0 900 242 922 1 1
RIPK1 ATG16L1 0 0 293 293 1 2
RIPK1 PIK3CD 0 0 62 180 1 1
RIPK1 NOD2 270 0 457 586 1 2
RIPK1 SLC25A5 99 0 46 158 1 1
RIPK1 CIB1 0 0 0 157 1 1
RIPK1 FRMPD2 0 0 0 193 1 1
RIPK1 RABGEF1 0 0 66 190 1 1
RIPK1 ROBO2 0 0 0 150 1 1
RIPK1 YOD1 270 0 0 285 1 1
RIPK1 ENAH 0 0 0 158 1 1
RIPK1 EIF2AK3 0 0 242 167 1 2
RIPK1 WWP2 0 0 72 232 1 1
RIPK1 TNFSF12 0 900 369 934 1 1
RIPK1 STAT6 0 0 53 194 1 1
RIPK1 USP2 486 900 257 959 1 1
RIPK1 MCU 0 0 469 469 1 2
RIPK1 SPRED1 0 0 0 158 1 1
RIPK1 YWHAB 0 0 0 165 1 1
RIPK1 STAMBP 0 0 150 190 1 1
RIPK1 SRC 0 0 323 152 1 2
RIPK1 GRAP 0 0 52 186 1 1
RIPK1 SMURF2 0 0 92 203 1 1
RIPK1 GPN2 0 0 0 158 1 1
RIPK1 USP8 0 0 181 193 1 1
RIPK1 RBX1 0 0 122 177 1 1
RIPK1 HACE1 0 0 166 294 1 1
RIPK1 LGALS9C 0 0 0 266 1 1
RIPK1 PPM1D 0 0 60 214 1 1
RIPK1 CDKN1B 0 0 101 276 1 2
RIPK1 MLF1 270 0 0 270 1 1
RIPK1 HMOX1 0 0 210 241 1 2
RIPK1 TICAM2 0 800 259 868 1 1
RIPK1 LRRK1 0 0 160 153 1 1
RIPK1 TOMM20 0 0 202 214 1 2
RIPK1 PIAS4 0 0 269 296 1 1
RIPK1 STX17 0 0 108 174 1 2
RIPK1 USP1 270 0 81 317 1 1
RIPK1 EIF2S1 0 0 203 220 1 2
RIPK1 ERAL1 0 0 0 157 1 1
RIPK1 PTPRQ 0 0 0 181 1 1
RIPK1 BRDT 0 0 0 159 1 1
RIPK1 PANX1 0 0 212 212 1 1
RIPK1 ATF6 0 0 249 267 1 2
RIPK1 IKBKB 487 900 701 963 1 2
RIPK1 KCNJ6 0 0 254 311 1 1
RIPK1 PDK3 0 0 0 197 1 1
RIPK1 XIAP 486 800 620 962 1 2
RIPK1 PPP2R4 0 0 171 211 1 1
RIPK1 UBE3A 0 0 131 182 1 1
RIPK1 PPARG 0 0 151 200 1 2
RIPK1 AKT1 0 0 450 233 1 2
RIPK1 TGFB2 0 0 49 157 1 1
RIPK1 IGLON5 0 0 53 161 1 1
RIPK1 LY96 0 600 260 701 1 1
RIPK1 SGK3 0 0 45 198 1 1
RIPK1 SYNE2 0 0 0 158 1 1
RIPK1 CARD8 0 0 307 322 1 1
RIPK1 CARD14 0 0 70 491 1 1
RIPK1 GNAL 0 0 0 158 1 1
RIPK1 UCKL1 0 0 0 171 1 1
RIPK1 CD4 0 0 464 485 1 2
RIPK1 MAP3K1 0 900 254 915 1 1
RIPK1 PYCARD 270 0 294 471 1 2
RIPK1 CCNE2 0 0 0 259 1 1
RIPK1 TLR9 0 0 415 452 1 2
RIPK1 IRF3 0 0 600 606 1 2
RIPK1 GYS2 0 0 0 157 1 1
RIPK1 UBE2E2 0 0 84 151 1 1
RIPK1 ERBB2 0 0 157 155 1 2
RIPK1 BBC3 0 0 213 213 1 2
RIPK1 NLRP7 0 0 139 191 1 1
RIPK1 ARPIN 0 0 95 194 1 1
RIPK1 TMEM9B 0 0 139 190 1 1
RIPK1 BIRC5 0 0 139 206 1 2
RIPK1 LGALS9B 0 0 0 266 1 1
RIPK1 MALT1 0 0 548 617 1 1
RIPK1 CXCL10 0 0 260 276 1 2
RIPK1 RNF7 0 0 0 158 1 1
RIPK1 BIRC8 0 0 244 332 1 1
RIPK1 ATF3 0 0 141 194 1 2
RIPK1 PARD6A 0 0 0 189 1 1
RIPK1 USP19 0 0 150 191 1 1
RIPK1 IRF7 0 0 594 619 1 1
RIPK1 TFRC 0 0 107 196 1 1
RIPK1 RPS6KA2 0 0 103 159 1 1
RIPK1 MAP3K14 270 900 229 935 1 1
RIPK1 TNFAIP3 875 900 556 994 1 2
RIPK1 NFKB2 0 650 459 827 1 1
RIPK1 RAB7A 0 0 117 171 1 2
RIPK1 TXNIP 0 0 113 164 1 2
RIPK1 BMF 0 0 284 284 1 1
RIPK1 CSNK2A1 117 0 73 239 1 1
RIPK1 IFI16 0 0 184 201 1 1
RIPK1 NAIP 0 0 294 349 1 1
RIPK1 FIS1 0 0 134 203 1 2
RIPK1 MAP4K2 0 900 54 902 1 1
RIPK1 SLC7A11 0 0 181 209 1 2
RIPK1 RNF135 0 600 136 645 1 1
RIPK1 RBFOX3 0 0 154 166 1 1
RIPK1 ZFAND5 213 0 0 247 1 1
RIPK1 USP14 0 0 134 162 1 2
RIPK1 ITCH 270 0 324 644 1 1
RIPK1 PPP1R15A 0 0 138 167 1 2
RIPK1 NBR1 0 0 193 277 1 2
RIPK1 TNF 913 900 731 998 1 2
RIPK1 C22orf29 0 0 338 338 1 1
RIPK1 TRAP1 0 0 0 174 1 2
RIPK1 NUMBL 111 0 48 243 1 1
RIPK1 KIF14 0 0 0 178 1 1
RIPK1 EGFL7 0 0 0 331 1 1
RIPK1 CAT 0 0 210 246 1 2
RIPK1 PDPK1 0 0 140 200 1 2
RIPK1 GRID1 0 0 0 150 1 2
RIPK1 CTLA4 0 0 202 214 1 2
RIPK1 RNASEL 0 0 149 369 1 1
RIPK1 BAK1 0 0 267 298 1 2
RIPK1 ATR 0 0 60 160 1 2
RIPK1 BCL2L2 0 0 181 181 1 1
RIPK1 CD274 0 0 140 431 1 2
RIPK1 RBM41 0 0 94 156 1 1
RIPK1 ZNF569 0 0 213 245 1 1
RIPK1 CLIC3 0 0 0 150 1 1
RIPK1 REM1 0 0 0 176 1 1
RIPK1 RPS6KB1 0 0 150 166 1 2
RIPK1 TTBK1 0 0 0 164 1 1
RIPK1 ERC1 0 0 194 194 1 1
RIPK1 CBL 270 0 113 438 1 1
RIPK1 HSPA9 118 0 72 255 1 1
RIPK1 IRS1 0 0 96 188 1 2
RIPK1 SPNS2 0 0 74 170 1 1
RIPK1 H2AFX 0 0 162 176 1 1
RIPK1 MAVS 0 800 923 986 1 2
RIPK1 IL1A 0 0 359 359 1 1
RIPK1 LLGL1 0 0 0 158 1 1
RIPK1 PPP2R5A 0 0 48 150 1 1
RIPK1 RNF31 486 800 780 975 1 1
RIPK1 OTUB2 0 0 154 153 1 1
RIPK1 SNX15 0 0 0 204 1 1
RIPK1 ZNF763 0 0 217 249 1 1
RIPK1 TRIM21 0 0 108 171 1 1
RIPK1 AIM2 0 0 384 384 1 2
RIPK1 DDX58 0 600 924 970 1 1
RIPK1 MAPKAPK2 0 0 143 227 1 1
RIPK1 YWHAG 0 0 0 188 1 1
RIPK1 MADD 0 900 0 900 1 1
RIPK1 TNFRSF10A 213 900 595 970 1 1
RIPK1 PPEF1 0 0 0 156 1 1
RIPK1 USP28 0 0 107 167 1 1
RIPK1 ZNF436 0 0 217 249 1 1
RIPK1 PPM1G 0 0 96 244 1 1
RIPK1 CASP8 913 900 989 999 1 2
RIPK1 XPO7 0 0 0 181 1 1
RIPK1 LRRFIP1 0 0 108 568 1 1
RIPK1 ALG1L2 0 0 0 157 1 1
RIPK1 TRIB1 0 0 42 182 1 1
RIPK1 GNAS 0 0 0 158 1 1
RIPK1 RPTOR 0 0 91 159 1 2
RIPK1 BPTF 0 0 0 276 1 1
RIPK1 DLG5 0 0 0 159 1 1
RIPK1 DAB2 0 0 390 437 1 1
RIPK1 PMEL 0 0 52 193 1 1
RIPK1 IL17A 0 0 242 241 1 2
RIPK1 RPS6KA3 0 0 134 170 1 1
RIPK1 TLR7 0 0 413 454 1 2
RIPK1 ZNF7 0 0 391 416 1 1
RIPK1 MAPK9 0 0 241 222 1 2
RIPK1 RPS6KA4 0 0 0 161 1 1
RIPK1 CASP9 0 0 556 566 1 2
RIPK1 GRAPL 0 0 0 170 1 1
RIPK1 USP36 0 0 109 155 1 1
RIPK1 BCKDK 0 0 0 197 1 1
RIPK1 NSMAF 0 900 0 902 1 1
RIPK1 SHANK2 0 0 0 161 1 1
RIPK1 GLUD1 0 0 299 309 1 1
RIPK1 PRF1 0 0 162 161 1 1
RIPK1 CISH 0 0 143 226 1 1
RIPK1 IFIH1 0 600 460 790 1 1
RIPK1 SPRED3 0 0 0 158 1 1
RIPK1 HIST2H3PS2 0 0 154 175 1 1
RIPK1 TNS1 0 0 95 167 1 1
RIPK1 OTUB1 0 0 218 218 1 1
RIPK1 CSNK1A1 270 0 123 411 1 1
RIPK1 MIB2 0 0 148 279 1 1
RIPK1 USP4 486 900 321 962 1 1
RIPK1 YWHAE 0 0 0 165 1 1
RIPK1 VCP 0 0 74 163 1 2
RIPK1 PELI3 0 0 97 294 1 1
RIPK1 TICAM1 675 900 961 998 1 2
RIPK1 GRN 0 0 90 190 1 1
RIPK1 TNFRSF8 0 0 158 161 1 1
RIPK1 RASD1 0 0 57 157 1 1
RIPK1 RIPK2 270 0 692 463 1 2
RIPK1 TCF7 0 0 57 162 1 1
RIPK1 CD8A 0 0 358 368 1 1
RIPK1 CALR 0 0 181 193 1 1
RIPK1 CDC20 0 0 91 165 1 1
RIPK1 MAP2K3 0 900 194 912 1 1
RIPK1 VRK2 0 0 0 164 1 1
RIPK1 TNFSF10 486 900 557 975 1 2
RIPK1 CAV1 0 900 84 907 1 2
RIPK1 HSPA1A 118 0 106 263 1 1
RIPK1 CASP1 0 0 609 639 1 2
RIPK1 BAG5 0 0 0 257 1 1
RIPK1 SNCA 0 0 143 349 1 2
RIPK1 ZNF629 0 0 217 249 1 1
RIPK1 TNIP3 0 0 141 218 1 1
RIPK1 TMEM173 0 0 260 288 1 1
RIPK1 RHOT1 0 0 54 151 1 1
RIPK1 MAPK12 0 0 74 174 1 1
RIPK1 BCL2L11 0 0 401 410 1 2
RIPK1 HTRA2 0 0 263 347 1 1
RIPK1 COX4I1 0 0 153 166 1 1
RIPK1 TFEB 0 0 157 171 1 2
RIPK1 SP7 0 0 71 170 1 1
RIPK1 CSNK1E 0 0 0 164 1 1
RIPK1 BRCC3 0 0 140 155 1 1
RIPK1 KEAP1 0 0 212 212 1 2
RIPK1 ROS1 0 0 0 177 1 1
RIPK1 CIT 270 0 55 286 1 1
RIPK1 INS 0 0 193 193 1 2
RIPK1 ACTB 0 0 468 495 1 2
RIPK1 AK2 0 0 326 325 1 1
RIPK1 WNT6 0 0 0 163 1 1
RIPK1 CD40 0 0 341 444 1 2
RIPK1 STUB1 0 900 241 925 1 2
RIPK1 RFK 0 0 182 204 1 1
RIPK1 TLR5 0 0 283 333 1 1
RIPK1 RHOQ 0 0 54 198 1 1
RIPK1 UBE2N 270 900 423 955 1 1
RIPK1 JUP 0 0 0 171 1 1
RIPK1 LLGL2 0 0 0 158 1 1
RIPK1 EIF4G1 0 0 107 186 1 2
RIPK1 PARP1 0 0 459 473 1 2
RIPK1 RHOA 0 0 123 213 1 2
RIPK1 HSPA8 118 0 112 271 1 2
RIPK1 UBE2L3 0 0 150 193 1 1
RIPK1 GABARAPL1 0 0 210 261 1 2
RIPK1 PDK2 0 0 0 197 1 1
RIPK1 UNC93B1 0 0 150 191 1 1
RIPK1 MLKL 270 650 988 844 1 2
RIPK1 NIM1K 0 0 0 158 1 1
RIPK1 CBLC 0 0 0 203 1 1
RIPK1 TNFRSF1A 992 900 989 999 1 1
RIPK1 EGFL8 0 0 0 235 1 1
RIPK1 IL6 0 0 469 469 1 2
RIPK1 FRAT2 0 0 0 151 1 1
RIPK1 MPO 0 0 183 213 1 2
RIPK1 RAB12 0 0 52 191 1 2
RIPK1 DDX21 0 0 124 292 1 1
RIPK1 NLRP1 0 0 279 279 1 1
RIPK1 APOBEC3G 0 0 306 316 1 1
RIPK1 VNN1 0 0 0 200 1 1
RIPK1 PRMT1 117 0 0 195 1 1
RIPK1 CD40LG 0 0 218 230 1 1
RIPK1 NOTCH1 0 0 142 199 1 2
RIPK1 PTPN13 0 0 100 160 1 1
RIPK1 GRIP1 0 0 0 172 1 1
RIPK1 TRAF4 0 0 287 349 1 1
RIPK1 PIDD1 486 900 932 973 1 1
RIPK1 TNFRSF1B 270 900 270 944 1 1
RIPK1 CSNK1G1 0 0 70 150 1 1
RIPK1 MAP1LC3A 0 0 181 235 1 2
RIPK1 GRIK3 0 0 0 150 1 1
RIPK1 DOK7 0 0 0 175 1 1
RIPK1 MAPK13 0 0 75 175 1 1
RIPK1 TMED7-TICAM2 0 0 0 151 1 1
RIPK1 RNF11 270 0 393 589 1 1
RIPK1 IL1B 0 0 563 627 1 2
RIPK1 HIF1A 0 0 258 280 1 2
RIPK1 TRAF5 486 800 824 982 1 1
RIPK1 PYGL 0 0 322 352 1 1
RIPK1 HCLS1 0 0 0 163 1 1
RIPK1 TRPM7 0 0 244 243 1 1
RIPK1 CLIC6 0 0 0 150 1 1
RIPK1 NF1 0 0 54 166 1 1
RIPK1 GABARAPL2 0 0 213 263 1 2
RIPK1 CD14 0 600 0 611 1 1
RIPK1 ATG14 0 0 181 198 1 2
RIPK1 TNFRSF25 270 900 322 949 1 1
RIPK1 TLR4 0 600 671 885 1 2
RIPK1 SMAD2 0 0 96 158 1 2
RIPK1 CCDC50 462 0 113 502 1 1
RIPK1 TUBB4A 118 0 57 159 1 1
RIPK1 BCL2L1 0 0 470 470 1 2
RIPK1 TAB3 0 800 647 931 1 1
RIPK1 ZRANB1 0 0 213 237 1 1
RIPK1 CLEC7A 0 0 181 195 1 1
RIPK1 LONRF2 0 0 0 200 1 1
RIPK1 PIK3R4 0 0 117 211 1 2
RIPK1 MAPRE2 0 0 74 356 1 1
RIPK1 PLEC 0 0 0 169 1 1
RIPK1 MAPKBP1 0 0 0 185 1 1
RIPK1 PDP2 0 0 0 201 1 1
RIPK1 GSDMA 0 0 324 323 1 1
RIPK1 RGS4 0 0 0 234 1 1
RIPK1 HSPD1 0 0 72 196 1 1
RIPK1 LGALS9 0 0 56 277 1 1
RIPK1 ANXA5 0 0 506 516 1 2
RIPK1 CCNB1 0 0 150 222 1 1
RIPK1 CCL5 0 0 243 260 1 2
RIPK1 TGFB3 0 0 47 155 1 1
RIPK1 BIRC2 880 900 985 999 1 1
RIPK1 IFNG 0 0 205 259 1 2
RIPK1 COX5A 270 0 0 270 1 1
RIPK1 HSPA1L 118 0 0 209 1 1
RIPK1 KCNJ11 0 0 217 229 1 1
RIPK1 HAVCR1 0 0 108 204 1 1
RIPK1 MAPK4 0 0 74 176 1 1
RIPK1 MAP2K1 0 0 187 231 1 1
RIPK1 PPIF 0 0 518 526 1 1
RIPK1 FBXO48 0 0 134 270 1 1
RIPK1 MFF 0 0 293 293 1 1
RIPK1 DHX58 0 0 335 368 1 1
RIPK1 UBBP4 0 0 0 153 1 1
RIPK1 VASP 0 0 0 159 1 1
RIPK1 RBCK1 486 800 606 957 1 1
RIPK1 NLRP12 0 0 125 277 1 1
RIPK1 CD80 0 0 150 184 1 2
RIPK1 UCK1 0 0 0 171 1 1
RIPK1 ENSG00000272772 0 0 0 196 1 1
RIPK1 WDR62 0 0 0 185 1 1
RIPK1 MAP2K5 0 0 181 232 1 1
RIPK1 PGAM5 270 0 969 977 1 1
RIPK1 NFE2L2 0 0 117 193 1 2
RIPK1 TLR1 0 0 310 359 1 1
RIPK1 STXBP6 0 0 0 158 1 1
RIPK1 SHANK1 0 0 0 161 1 1
RIPK1 UBD 0 0 223 273 1 1
RIPK1 EFNA5 0 0 0 168 1 1
RIPK1 TAX1BP1 486 600 544 903 1 2
RIPK1 OR4D10 0 0 95 151 1 1
RIPK1 SMAD4 0 0 95 157 1 2
RIPK1 PPP3CC 0 0 66 188 1 1
RIPK1 EFNA4 0 0 0 168 1 1
RIPK1 GNAT2 0 0 0 177 1 1
RIPK1 ZNF536 0 0 0 160 1 1
RIPK1 PIK3CA 0 0 96 192 1 2
RIPK1 DHX33 0 0 142 313 1 1
RIPK1 PPP3CB 0 0 66 175 1 1
RIPK1 TAB1 270 900 751 983 1 1
RIPK1 GNAT3 0 0 0 177 1 1
RIPK1 TRAF2 915 900 988 999 1 2
RIPK1 MX1 0 0 156 171 1 1
RIPK1 CORO6 0 0 0 162 1 1
RIPK1 UBE2D1 0 900 324 931 1 1
RIPK1 AZI2 0 0 293 304 1 1
RIPK1 TAB2 835 900 987 999 1 2
RIPK1 IL18 0 0 458 457 1 2
RIPK1 ARL8B 0 0 0 151 1 1
RIPK1 MYC 0 0 294 312 1 2
RIPK1 PDK1 0 0 0 197 1 2
RIPK1 IL1R1 0 0 535 552 1 1
RIPK1 VDAC2 0 0 163 179 1 1
RIPK1 STAT3 0 0 322 410 1 2
RIPK1 MKKS 0 0 155 243 1 1
RIPK1 GATA3 0 0 118 214 1 1
RIPK1 TRIM23 0 0 81 203 1 1
RIPK1 ERN1 270 0 294 371 1 2
RIPK1 SH3BP5 0 0 289 336 1 1
RIPK1 RPGR 0 0 0 159 1 1
RIPK1 BAZ2A 0 0 63 205 1 1
RIPK1 HSCB 270 0 0 270 1 1
RIPK1 KDM7A 0 0 0 182 1 1
RIPK1 CRADD 486 900 419 968 1 1
RIPK1 LINGO1 0 0 150 192 1 1
RIPK1 ZNF44 0 0 217 249 1 1
RIPK1 SLMAP 0 0 0 239 1 1
RIPK1 ZNF304 0 0 65 159 1 1
RIPK1 DDIT3 0 0 218 236 1 2
RIPK1 TRAF1 606 900 600 984 1 1
RIPK1 SIAH2 0 0 96 157 1 1
RIPK1 CSF3 0 0 158 157 1 1
RIPK1 MYD88 0 0 561 637 1 2
RIPK1 CDK4 0 0 124 165 1 2
RIPK1 SARM1 0 900 431 940 1 1
RIPK1 FADD 913 900 989 999 1 2
RIPK1 TTBK2 0 0 0 164 1 1
RIPK1 PRKCE 0 0 70 178 1 1
RIPK1 BHLHA9 0 0 83 157 1 1
RIPK1 IRF9 0 0 218 219 1 1
RIPK1 PRKCI 0 900 0 900 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005524 Molecular Function ATP binding enables IEA
GO:0004706 Molecular Function JUN kinase kinase kinase activity enables IBA
GO:0070513 Molecular Function death domain binding enables IPI
GO:0005123 Molecular Function death receptor binding enables IPI
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0005515 Molecular Function protein binding enables IPI
GO:0042803 Molecular Function protein homodimerization activity enables IDA
GO:0004672 Molecular Function protein kinase activity enables IDA
GO:0004672 Molecular Function protein kinase activity enables IMP
GO:0106310 Molecular Function protein serine kinase activity enables IEA
GO:0004674 Molecular Function protein serine/threonine kinase activity enables IDA
GO:0004674 Molecular Function protein serine/threonine kinase activity enables IMP
GO:0004674 Molecular Function protein serine/threonine kinase activity enables TAS
GO:0044877 Molecular Function protein-containing complex binding enables IDA
GO:0031625 Molecular Function ubiquitin protein ligase binding enables IPI
GO:0000165 Biological Process MAPK cascade involved_in IEA
GO:0070231 Biological Process T cell apoptotic process involved_in ISS
GO:1990000 Biological Process amyloid fibril formation involved_in IMP
GO:0006915 Biological Process apoptotic process involved_in IMP
GO:0071363 Biological Process cellular response to growth factor stimulus involved_in IEA
GO:0070301 Biological Process cellular response to hydrogen peroxide involved_in ISS
GO:0071356 Biological Process cellular response to tumor necrosis factor involved_in IDA
GO:0097191 Biological Process extrinsic apoptotic signaling pathway involved_in IDA
GO:0097191 Biological Process extrinsic apoptotic signaling pathway involved_in IMP
GO:0006954 Biological Process inflammatory response involved_in IEA
GO:0035556 Biological Process intracellular signal transduction involved_in IDA
GO:0070266 Biological Process necroptotic process involved_in IMP
GO:0070266 Biological Process necroptotic process involved_in ISS
GO:0070266 Biological Process necroptotic process involved_in TAS
GO:0097527 Biological Process necroptotic signaling pathway involved_in IMP
GO:0097527 Biological Process necroptotic signaling pathway involved_in ISS
GO:0043066 Biological Process negative regulation of apoptotic process involved_in ISS
GO:0043124 Biological Process negative regulation of canonical NF-kappaB signal transduction involved_in IMP
GO:2001237 Biological Process negative regulation of extrinsic apoptotic signaling pathway involved_in IMP
GO:2001240 Biological Process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand involved_in IEA
GO:0060546 Biological Process negative regulation of necroptotic process involved_in ISS
GO:0036289 Biological Process peptidyl-serine autophosphorylation involved_in IDA
GO:0036289 Biological Process peptidyl-serine autophosphorylation involved_in IMP
GO:0046330 Biological Process positive regulation of JNK cascade involved_in IDA
GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IMP
GO:0043065 Biological Process positive regulation of apoptotic process involved_in IDA
GO:0043065 Biological Process positive regulation of apoptotic process involved_in IMP
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IDA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IEP
GO:2001238 Biological Process positive regulation of extrinsic apoptotic signaling pathway involved_in IMP
GO:0010628 Biological Process positive regulation of gene expression involved_in IDA
GO:0050729 Biological Process positive regulation of inflammatory response involved_in IMP
GO:0070105 Biological Process positive regulation of interleukin-6-mediated signaling pathway involved_in IMP
GO:0032757 Biological Process positive regulation of interleukin-8 production involved_in IDA
GO:0045651 Biological Process positive regulation of macrophage differentiation involved_in IMP
GO:1903800 Biological Process positive regulation of miRNA processing acts_upstream_of IDA
GO:0060545 Biological Process positive regulation of necroptotic process involved_in IMP
GO:0043525 Biological Process positive regulation of neuron apoptotic process involved_in IEA
GO:1901224 Biological Process positive regulation of non-canonical NF-kappaB signal transduction involved_in IEA
GO:0043068 Biological Process positive regulation of programmed cell death involved_in IMP
GO:0062100 Biological Process positive regulation of programmed necrotic cell death involved_in IMP
GO:0001934 Biological Process positive regulation of protein phosphorylation involved_in IMP
GO:2000379 Biological Process positive regulation of reactive oxygen species metabolic process involved_in TAS
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IDA
GO:0032760 Biological Process positive regulation of tumor necrosis factor production involved_in IDA
GO:1903265 Biological Process positive regulation of tumor necrosis factor-mediated signaling pathway involved_in IEA
GO:0097300 Biological Process programmed necrotic cell death involved_in ISS
GO:0046777 Biological Process protein autophosphorylation involved_in IDA
GO:0046777 Biological Process protein autophosphorylation involved_in IMP
GO:0030163 Biological Process protein catabolic process involved_in IDA
GO:0070926 Biological Process regulation of ATP:ADP antiporter activity involved_in IMP
GO:0006979 Biological Process response to oxidative stress involved_in IMP
GO:0034612 Biological Process response to tumor necrosis factor involved_in IMP
GO:0097343 Biological Process ripoptosome assembly involved_in IMP
GO:1901026 Biological Process ripoptosome assembly involved in necroptotic process involved_in IEA
GO:0033209 Biological Process tumor necrosis factor-mediated signaling pathway involved_in IC
GO:0005829 Cellular Component cytosol located_in TAS
GO:0031264 Cellular Component death-inducing signaling complex part_of IDA
GO:0010008 Cellular Component endosome membrane located_in TAS
GO:0005739 Cellular Component mitochondrion located_in IDA
GO:0005886 Cellular Component plasma membrane located_in TAS
GO:0032991 Cellular Component protein-containing complex part_of IDA
GO:0043235 Cellular Component receptor complex part_of IDA
GO:0097342 Cellular Component ripoptosome part_of IDA
Pathways
Name DB ID
Apoptosis Reactome R-HSA-109581
Caspase activation via Death Receptors in the presence of ligand Reactome R-HSA-140534
ZBP1(DAI) mediated induction of type I IFNs Reactome R-HSA-1606322
Signal Transduction Reactome R-HSA-162582
Disease Reactome R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade Reactome R-HSA-166016
MyD88-independent TLR4 cascade Reactome R-HSA-166166
Toll Like Receptor 3 (TLR3) Cascade Reactome R-HSA-168164
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Toll-like Receptor Cascades Reactome R-HSA-168898
TICAM1, RIP1-mediated IKK complex recruitment Reactome R-HSA-168927
DDX58/IFIH1-mediated induction of interferon-alpha/beta Reactome R-HSA-168928
RIP-mediated NFkB activation via ZBP1 Reactome R-HSA-1810476
Cytosolic sensors of pathogen-associated DNA Reactome R-HSA-1834949
TRIF-mediated programmed cell death Reactome R-HSA-2562578
Stimuli-sensing channels Reactome R-HSA-2672351
TRP channels Reactome R-HSA-3295583
Regulation by c-FLIP Reactome R-HSA-3371378
Transport of small molecules Reactome R-HSA-382551
Metabolism of proteins Reactome R-HSA-392499
RIPK1-mediated regulated necrosis Reactome R-HSA-5213460
Regulated Necrosis Reactome R-HSA-5218859
CASP8 activity is inhibited Reactome R-HSA-5218900
Caspase activation via extrinsic apoptotic signalling pathway Reactome R-HSA-5357769
TNFR1-induced proapoptotic signaling Reactome R-HSA-5357786
Programmed Cell Death Reactome R-HSA-5357801
Regulation of TNFR1 signaling Reactome R-HSA-5357905
TNFR1-induced NF-kappa-B signaling pathway Reactome R-HSA-5357956
Infectious disease Reactome R-HSA-5663205
Regulation of necroptotic cell death Reactome R-HSA-5675482
Deubiquitination Reactome R-HSA-5688426
Ub-specific processing proteases Reactome R-HSA-5689880
Ovarian tumor domain proteases Reactome R-HSA-5689896
Post-translational protein modification Reactome R-HSA-597592
Dimerization of procaspase-8 Reactome R-HSA-69416
Death Receptor Signaling Reactome R-HSA-73887
TNF signaling Reactome R-HSA-75893
TLR3-mediated TICAM1-dependent programmed cell death Reactome R-HSA-9013957
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Reactome R-HSA-933543
IKK complex recruitment mediated by RIP1 Reactome R-HSA-937041
TRIF(TICAM1)-mediated TLR4 signaling Reactome R-HSA-937061
Diseases of programmed cell death Reactome R-HSA-9645723
SARS-CoV-1 Infection Reactome R-HSA-9678108
Potential therapeutics for SARS Reactome R-HSA-9679191
SARS-CoV Infections Reactome R-HSA-9679506
Microbial modulation of RIPK1-mediated regulated necrosis Reactome R-HSA-9686347
SARS-CoV-1-mediated effects on programmed cell death Reactome R-HSA-9692913
SARS-CoV-1-host interactions Reactome R-HSA-9692914
Defective RIPK1-mediated regulated necrosis Reactome R-HSA-9693928
Viral Infection Pathways Reactome R-HSA-9824446
Ion channel transport Reactome R-HSA-983712
TLR4 signaling and tolerance (WP3851) WikiPathways WP3851_r121712
ATM signaling pathway (WP2516) WikiPathways WP2516_r116808
p38 MAPK signaling pathway (WP400) WikiPathways WP400_r123111
Apoptosis modulation by HSP70 (WP384) WikiPathways WP384_r121706
SARS-CoV-2 innate immunity evasion and cell-specific immune response (WP5039) WikiPathways WP5039_r124653
Toll-like receptor signaling pathway (WP75) WikiPathways WP75_r119233
Apoptosis (WP254) WikiPathways WP254_r118382
Pro-survival signaling of neuroprotectin D1 (WP5182) WikiPathways WP5182_r122168
TNF-related weak inducer of apoptosis (TWEAK) signaling pathway (WP2036) WikiPathways WP2036_r120940
Cytosolic DNA-sensing pathway (WP4655) WikiPathways WP4655_r123496
TNF-alpha signaling pathway (WP231) WikiPathways WP231_r124583
Apoptosis modulation and signaling (WP1772) WikiPathways WP1772_r120736
Nanoparticle triggered regulated necrosis (WP2513) WikiPathways WP2513_r119820
Host-pathogen interaction of human coronaviruses - interferon induction (WP4880) WikiPathways WP4880_r124638
Novel intracellular components of RIG-I-like receptor pathway (WP3865) WikiPathways WP3865_r123636
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_047419447 1 mRNA transcript variant X8 NC_000006 Reference
XM_047419448 1 mRNA transcript variant X1 NC_000006 Reference
NM_001317061 3 mRNA transcript variant 2 NC_000006 Reference
NM_001354932 2 mRNA transcript variant 5 NC_000006 Reference
NM_003804 6 mRNA transcript variant 1 NC_000006 Reference
NM_001354931 2 mRNA transcript variant 4 NC_000006 Reference
XM_017011405 2 mRNA transcript variant X5 NC_000006 Reference
NM_001354934 2 mRNA transcript variant 7 NC_000006 Reference
NM_001354933 2 mRNA transcript variant 6 NC_000006 Reference
NM_001354930 2 mRNA transcript variant 3 NC_000006 Reference
XM_006715237 4 mRNA transcript variant X2 NC_000006 Reference
XM_047419445 1 mRNA transcript variant X6 NC_000006 Reference
XM_047419446 1 mRNA transcript variant X7 NC_000006 Reference
XM_017011403 2 mRNA transcript variant X3 NC_000006 Reference
XM_017011404 3 mRNA transcript variant X4 NC_000006 Reference