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RIPK2

receptor interacting serine/threonine kinase 2
General Information
Name receptor interacting serine/threonine kinase 2
Alias
  • receptor-interacting serine/threonine-protein kinase 2
  • CARD-carrying kinase
  • CARD-containing IL-1 beta ICE-kinase
  • CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase
  • RIP-2
  • growth-inhibiting gene 30
  • receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase
  • receptor-interacting protein 2
  • tyrosine-protein kinase RIPK2
Gene_family Caspase recruitment domain containing
organism Homo sapiens
entrez_id 8767
location 8q21.3
transcript_count 3
exon_count 12
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
    Stringdb Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3 [...]
    nextProt Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:9575181, PubMed:9642260, PubMed:17054981, PubMed:21123652, PubMed:21887730, PubMed:28656966). Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains (PubMed:17054981, PubMed:21123652, PubMed:28656966). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (PubMed:21123652). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB (PubMed:18079694). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18079694). Also plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
RIPK2 BioGRID NLRX1 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID PRDX5 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID CTR9 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID C6orf120 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID TMUB1 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID COG3 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID MRPL2 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID CNOT1 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID ERLIN2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
RIPK2 BioGRID IGF2BP2 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID ERLIN1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
RIPK2 BioGRID SLK GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID YWHAH GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID TRAF3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RIPK2 BioGRID TRAF2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
RIPK2 BioGRID STK10 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID CAMK4 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID XIAP GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
RIPK2 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
RIPK2 BioGRID RNF168 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID ATF6 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID YWHAQ GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RIPK2 BioGRID EIF2AK3 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID YWHAG GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RIPK2 BioGRID YWHAE GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RIPK2 BioGRID YWHAB GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RIPK2 BioGRID ERN1 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID STRAP GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID PPP1R8 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID ATG16L1 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID VIM GeneID BioGRID Proximity Label-MS
RIPK2 BioGRID TLR2 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID PRPH GeneID BioGRID Proximity Label-MS
RIPK2 BioGRID CLTA GeneID BioGRID Proximity Label-MS
RIPK2 BioGRID NGFR GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID RIPK2 GeneID BioGRID Biochemical Activity; Two-hybrid
RIPK2 BioGRID BMH1 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID BMH2 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID NOD1 GeneID BioGRID Affinity Capture-Western; FRET; Reconstituted Complex
RIPK2 BioGRID NOD2 GeneID BioGRID Affinity Capture-Western; FRET; Two-hybrid
RIPK2 BioGRID BIRC2 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RIPK2 BioGRID ZNRF4 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
RIPK2 BioGRID TRIM14 GeneID BioGRID Proximity Label-MS
RIPK2 BioGRID UBC GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID IRF4 GeneID BioGRID Affinity Capture-Western; Co-localization
RIPK2 BioGRID CEP43 GeneID BioGRID Proximity Label-MS
RIPK2 BioGRID CARD16 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID NXF1 GeneID BioGRID Affinity Capture-RNA
RIPK2 BioGRID SHMT2 GeneID BioGRID Affinity Capture-RNA
RIPK2 BioGRID MOV10 GeneID BioGRID Affinity Capture-RNA
RIPK2 BioGRID KDM3A GeneID BioGRID Two-hybrid
RIPK2 BioGRID PRMT2 GeneID BioGRID Two-hybrid
RIPK2 BioGRID PELI3 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
RIPK2 BioGRID MAP3K7 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID CHUK GeneID BioGRID Biochemical Activity
RIPK2 BioGRID LRRK2 GeneID BioGRID Biochemical Activity
RIPK2 BioGRID TRAF4 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID MAP3K4 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID CASP12 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID NAT16 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID RNF31 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID RIPK1 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID MAVS GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
RIPK2 BioGRID TAB2 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID TAB1 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID IKBKG GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID BIRC3 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RIPK2 Protein CARD16 GeneID HPRD
RIPK2 Protein CARD6 GeneID HPRD
RIPK2 Protein UBE2I GeneID HPRD
RIPK2 Protein SMURF1 GeneID HPRD
RIPK2 Protein NOD1 GeneID HPRD
RIPK2 Protein NOD2 GeneID HPRD
RIPK2 Protein CFLAR GeneID HPRD
RIPK2 Protein BCL10 GeneID HPRD
RIPK2 Protein TLR4 GeneID HPRD
RIPK2 Protein TLR2 GeneID HPRD
RIPK2 Protein TRAF5 GeneID HPRD
RIPK2 Protein TRAF6 GeneID HPRD
RIPK2 Protein TRAF2 GeneID HPRD
RIPK2 Protein CASP8 GeneID HPRD
RIPK2 Protein BIRC3 GeneID HPRD
RIPK2 Protein TRAF1 GeneID HPRD
RIPK2 Protein SMAD4 GeneID HPRD
RIPK2 Protein IRAK1 GeneID HPRD
RIPK2 Protein IKBKG GeneID HPRD
RIPK2 Protein TNFRSF1A GeneID HPRD
RIPK2 Protein NGFR GeneID HPRD
RIPK2 Protein CASP1 GeneID HPRD
RIPK2 Protein CD40 GeneID HPRD
RIPK2 BioGRID CFLAR GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID TRAF5 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID TRAF1 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID TNFRSF1A GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID CD40 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID CASP1 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID CARD6 GeneID BioGRID Affinity Capture-Western
RIPK2 BioGRID KCTD12 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID PHB2 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID RPS14 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID RPL38 GeneID BioGRID Affinity Capture-MS
RIPK2 BioGRID UBE2I GeneID BioGRID Two-hybrid
RIPK2 Protein NOD1 GeneID BIND Nod1 interacts with, and enhances RICK activity.
RIPK2 Protein NOD2 GeneID BIND Nod2 interaction with RICK enhances NF-kappaB activity
StringDB
A B experiments database textmining combined score hadb nhadb
RIPK2 PPM1B 0 0 0 236 1 1
RIPK2 TNFSF13B 0 0 155 154 1 1
RIPK2 TONSL 0 0 0 150 1 1
RIPK2 TNFRSF10B 0 0 181 203 1 2
RIPK2 UFSP2 0 0 82 186 1 1
RIPK2 IL13 0 0 180 179 1 2
RIPK2 RAB20 0 0 74 170 1 1
RIPK2 MAPK15 0 0 81 218 1 1
RIPK2 UBE2V1 0 600 253 688 1 1
RIPK2 REL 0 0 294 366 1 2
RIPK2 NLRP3 0 0 642 655 1 2
RIPK2 NCAPH 0 0 0 191 1 1
RIPK2 ELF3 0 0 66 155 1 1
RIPK2 CARD16 462 0 445 702 1 1
RIPK2 LTK 0 0 0 178 1 1
RIPK2 SMURF1 94 0 96 238 1 1
RIPK2 PTGS2 0 0 247 312 1 2
RIPK2 CASP3 0 0 283 299 1 2
RIPK2 NOD2 879 900 989 999 1 2
RIPK2 CIITA 0 0 386 386 1 1
RIPK2 ATG16L1 0 0 522 531 1 2
RIPK2 TXNRD1 0 0 87 197 1 1
RIPK2 CEBPB 0 0 193 268 1 2
RIPK2 LTBR 0 0 213 282 1 1
RIPK2 ACO1 0 0 0 164 1 1
RIPK2 RIPK1 270 0 692 463 1 2
RIPK2 CDKN2A 0 0 82 157 1 2
RIPK2 CCNG1 0 0 42 159 1 1
RIPK2 GSK3B 0 0 82 164 1 2
RIPK2 INSRR 0 0 0 187 1 1
RIPK2 DUSP2 0 0 54 156 1 1
RIPK2 PLCZ1 0 0 60 155 1 1
RIPK2 KIAA1614 0 0 0 189 1 1
RIPK2 FOXK1 0 0 0 162 1 1
RIPK2 DCP1A 0 0 0 163 1 1
RIPK2 PKN2 0 0 194 198 1 1
RIPK2 CORO1C 0 0 0 162 1 1
RIPK2 RND2 0 0 66 162 1 1
RIPK2 TSSK4 0 0 112 183 1 1
RIPK2 FASLG 0 900 206 923 1 1
RIPK2 RHOD 0 0 53 150 1 1
RIPK2 SOCS3 0 0 204 271 1 1
RIPK2 BIRC7 0 0 68 159 1 1
RIPK2 STAT5A 0 0 95 194 1 1
RIPK2 TNIP1 0 0 210 261 1 1
RIPK2 FAF1 0 900 0 904 1 1
RIPK2 TNIP2 0 0 261 296 1 1
RIPK2 SYNRG 0 0 0 207 1 1
RIPK2 ENSG00000251246 0 0 0 168 1 1
RIPK2 IL18R1 0 0 182 194 1 1
RIPK2 SNX16 0 0 81 656 1 1
RIPK2 CARD11 0 900 323 936 1 1
RIPK2 FBXL19 0 0 0 194 1 1
RIPK2 EEF1G 0 0 0 195 1 1
RIPK2 MYO16 0 0 74 154 1 1
RIPK2 MAPT 0 0 51 151 1 2
RIPK2 BECN1 0 0 181 213 1 2
RIPK2 ANXA1 0 0 0 161 1 1
RIPK2 IL2 0 0 206 206 1 1
RIPK2 TLR6 0 0 283 382 1 1
RIPK2 GYS1 0 0 0 157 1 1
RIPK2 DNAJC10 0 0 0 166 1 1
RIPK2 NCAPD2 0 0 0 180 1 1
RIPK2 DUSP1 0 0 92 189 1 1
RIPK2 MAPK11 0 650 201 752 1 1
RIPK2 PPM1A 0 0 0 198 1 1
RIPK2 OPTN 0 0 193 205 1 2
RIPK2 MAP3K4 270 0 836 553 1 1
RIPK2 PDK4 0 0 0 197 1 1
RIPK2 UBE2D2 0 0 85 298 1 1
RIPK2 IFNB1 0 0 459 459 1 1
RIPK2 CHKB 0 0 0 159 1 1
RIPK2 ESR1 0 0 134 166 1 2
RIPK2 PIM2 0 0 95 236 1 1
RIPK2 IL10RB 0 0 180 192 1 1
RIPK2 IRF1 0 0 294 368 1 2
RIPK2 MIB1 0 0 0 188 1 1
RIPK2 EPHX1 0 0 0 172 1 1
RIPK2 TNFAIP2 0 0 134 255 1 1
RIPK2 LRPPRC 0 0 0 156 1 2
RIPK2 CALCOCO2 0 0 231 230 1 2
RIPK2 TRIP6 0 800 171 840 1 1
RIPK2 TNIK 0 0 90 178 1 1
RIPK2 ILKAP 0 0 74 252 1 1
RIPK2 PRKD1 0 0 82 203 1 1
RIPK2 UBC 270 0 43 322 1 2
RIPK2 PIGA 0 0 0 157 1 1
RIPK2 MAP1LC3B 0 0 108 165 1 2
RIPK2 EFNA2 0 0 0 168 1 1
RIPK2 SLC15A3 0 0 497 514 1 1
RIPK2 MST1R 0 0 0 181 1 1
RIPK2 AGL 0 0 0 306 1 1
RIPK2 PIP4K2C 0 0 134 160 1 1
RIPK2 C3 0 0 82 181 1 2
RIPK2 CSNK2B 0 0 0 177 1 1
RIPK2 SPRED2 0 0 0 158 1 2
RIPK2 MAPKAPK3 0 0 129 296 1 1
RIPK2 PKN3 0 0 116 167 1 1
RIPK2 RIPK4 0 0 408 259 1 1
RIPK2 PKN1 0 0 90 157 1 1
RIPK2 CCL3 0 0 181 181 1 1
RIPK2 BROX 0 0 96 342 1 1
RIPK2 ATP7B 0 0 0 152 1 1
RIPK2 IL18RAP 0 0 217 234 1 1
RIPK2 TSPAN6 0 0 134 151 1 1
RIPK2 MRAS 0 0 0 176 1 1
RIPK2 IL10 0 0 370 382 1 2
RIPK2 IRAK4 0 0 324 156 1 1
RIPK2 GDF15 0 0 55 194 1 1
RIPK2 DYRK1B 0 0 86 174 1 1
RIPK2 SKAP2 0 0 45 168 1 1
RIPK2 GTF2E2 0 0 82 190 1 1
RIPK2 HCFC2 0 0 49 151 1 1
RIPK2 NME8 0 0 0 164 1 1
RIPK2 LTA4H 0 0 326 359 1 1
RIPK2 NLRP6 0 0 373 373 1 1
RIPK2 STK40 0 0 0 162 1 1
RIPK2 SLC9C2 0 0 0 175 1 1
RIPK2 DSTYK 0 0 323 166 1 1
RIPK2 TNFRSF9 0 0 138 200 1 1
RIPK2 CLEC4E 0 0 188 219 1 1
RIPK2 BAG1 0 0 66 169 1 2
RIPK2 MARK2 0 0 150 222 1 1
RIPK2 NGFR 887 900 730 996 1 1
RIPK2 TSSK6 0 0 73 169 1 1
RIPK2 CORO1B 0 0 0 162 1 1
RIPK2 NLK 0 0 107 169 1 1
RIPK2 LOC110117498-PIK3R3 0 0 0 241 1 1
RIPK2 KIT 0 0 118 192 1 2
RIPK2 PTPN2 0 0 104 212 1 2
RIPK2 BAK1 0 0 231 268 1 2
RIPK2 SSH3 0 0 0 151 1 1
RIPK2 RNASEL 0 0 154 240 1 1
RIPK2 ZCCHC7 0 0 0 225 1 1
RIPK2 GRID1 0 0 0 150 1 2
RIPK2 CTLA4 0 0 151 164 1 2
RIPK2 PDPK1 0 900 73 922 1 2
RIPK2 DUSP6 0 0 0 254 1 1
RIPK2 HELZ2 0 0 66 193 1 1
RIPK2 KIF14 118 0 0 193 1 1
RIPK2 NUMBL 0 0 0 159 1 1
RIPK2 TRAF3IP2 0 0 135 164 1 1
RIPK2 OSBPL10 0 0 0 157 1 1
RIPK2 ATG2A 0 0 66 179 1 2
RIPK2 HRK 0 0 202 220 1 1
RIPK2 EGR2 0 0 96 164 1 1
RIPK2 HSPA9 0 0 0 163 1 1
RIPK2 CBL 0 0 57 311 1 1
RIPK2 IRS1 0 0 81 175 1 2
RIPK2 GAMT 0 0 0 211 1 1
RIPK2 CRBN 0 0 391 432 1 1
RIPK2 NKIRAS1 0 0 67 189 1 1
RIPK2 CDK1 0 0 123 182 1 2
RIPK2 NLRP2 0 0 411 473 1 1
RIPK2 TTBK1 0 0 0 164 1 1
RIPK2 CLIC3 0 0 0 150 1 1
RIPK2 CD274 0 0 97 155 1 2
RIPK2 TXNIP 0 0 171 226 1 2
RIPK2 IFI16 0 0 218 218 1 1
RIPK2 DRAM1 0 0 92 177 1 2
RIPK2 TNFAIP3 0 900 367 941 1 2
RIPK2 NFKB2 0 0 249 362 1 1
RIPK2 CD70 0 0 143 292 1 1
RIPK2 RPS6KA2 0 0 95 156 1 1
RIPK2 IL5 0 0 166 165 1 1
RIPK2 RHEBL1 0 0 70 206 1 1
RIPK2 IRF7 0 0 391 413 1 1
RIPK2 PARD6A 0 0 0 189 1 1
RIPK2 ATF3 0 0 123 248 1 2
RIPK2 IL1RN 0 0 166 226 1 1
RIPK2 PIK3R2 0 0 49 493 1 1
RIPK2 TRAP1 0 0 0 174 1 2
RIPK2 ITK 0 0 67 215 1 1
RIPK2 SEL1L3 0 0 85 156 1 1
RIPK2 UBL7 0 0 0 164 1 1
RIPK2 NBR1 0 0 150 256 1 2
RIPK2 TNF 0 0 502 531 1 2
RIPK2 ITCH 0 900 338 938 1 1
RIPK2 ATXN2L 0 0 0 179 1 1
RIPK2 NAIP 0 0 460 502 1 1
RIPK2 UCKL1 0 0 0 176 1 1
RIPK2 GNAL 0 0 0 158 1 1
RIPK2 CD4 0 0 320 336 1 2
RIPK2 SIK1B 0 0 123 151 1 1
RIPK2 CARD8 0 0 537 547 1 1
RIPK2 CARD14 0 0 283 610 1 1
RIPK2 LY96 0 0 288 303 1 1
RIPK2 AAMP 0 0 210 240 1 1
RIPK2 TGFB2 0 0 66 172 1 1
RIPK2 AKT1 0 0 241 150 1 2
RIPK2 PPP2R4 0 0 113 155 1 1
RIPK2 UBR2 0 0 103 349 1 1
RIPK2 PDK3 0 0 0 197 1 1
RIPK2 XIAP 870 800 966 999 1 2
RIPK2 KCNJ6 0 0 175 258 1 1
RIPK2 PANX1 0 0 206 206 1 1
RIPK2 DEFB135 0 0 193 193 1 1
RIPK2 IKBKB 0 900 458 943 1 2
RIPK2 ATF6 0 0 113 157 1 2
RIPK2 BRDT 0 0 0 154 1 1
RIPK2 CXCL10 0 0 310 326 1 2
RIPK2 MALT1 0 0 323 404 1 1
RIPK2 BIRC8 0 0 245 315 1 1
RIPK2 TMEM9B 0 0 100 238 1 1
RIPK2 CCL3L3 0 0 159 158 1 1
RIPK2 NLRP7 0 0 320 391 1 1
RIPK2 PARP6 0 0 0 212 1 1
RIPK2 IRF3 0 0 465 477 1 2
RIPK2 UBE2E2 0 0 50 182 1 1
RIPK2 ERBB2 0 0 170 159 1 2
RIPK2 GYS2 0 0 0 157 1 1
RIPK2 TLR9 0 0 390 420 1 2
RIPK2 YME1L1 0 0 0 325 1 1
RIPK2 MAP3K1 0 0 181 160 1 1
RIPK2 PYCARD 0 0 502 560 1 2
RIPK2 FUCA1 0 0 52 197 1 1
RIPK2 GRAP 0 0 0 228 1 1
RIPK2 SMURF2 0 0 48 151 1 1
RIPK2 GPN2 0 0 0 158 1 1
RIPK2 SPRED1 0 0 0 158 1 1
RIPK2 MEF2B 0 0 137 295 1 1
RIPK2 YWHAB 0 0 46 171 1 1
RIPK2 ADCK3 0 0 113 152 1 1
RIPK2 LRRC2 0 0 57 150 1 1
RIPK2 COMMD10 0 0 94 346 1 1
RIPK2 STAT6 0 0 123 219 1 1
RIPK2 ENAH 0 0 0 158 1 1
RIPK2 WWP2 0 0 0 278 1 1
RIPK2 NAT16 270 0 0 270 1 1
RIPK2 EIF2AK3 0 0 161 190 1 2
RIPK2 FRMPD2 0 0 267 383 1 1
RIPK2 RABGEF1 0 0 0 168 1 1
RIPK2 ERAL1 0 0 0 156 1 1
RIPK2 PTPRQ 0 0 0 181 1 1
RIPK2 NFATC2 128 0 71 181 1 1
RIPK2 DNAJC17 0 0 0 158 1 1
RIPK2 LRRK1 0 0 218 235 1 1
RIPK2 TICAM2 0 0 154 221 1 1
RIPK2 TCHP 0 0 399 399 1 1
RIPK2 IL32 0 0 152 151 1 1
RIPK2 ZFYVE1 0 0 81 167 1 2
RIPK2 PPM1D 0 0 0 198 1 1
RIPK2 HACE1 0 0 0 188 1 1
RIPK2 RBX1 0 0 107 196 1 1
RIPK2 BNIP3L 0 0 166 224 1 2
RIPK2 RPS6KA6 0 0 138 173 1 1
RIPK2 CD40 270 0 282 540 1 2
RIPK2 ACTB 0 0 288 324 1 2
RIPK2 CSNK1E 0 0 0 164 1 1
RIPK2 ROS1 0 0 0 177 1 1
RIPK2 SPAG9 0 0 0 155 1 1
RIPK2 DYRK2 0 0 81 166 1 1
RIPK2 NLRP9 0 0 203 232 1 1
RIPK2 DEPDC7 0 0 95 295 1 1
RIPK2 MLKL 0 0 443 266 1 2
RIPK2 CBLC 0 0 0 203 1 1
RIPK2 NIM1K 0 0 0 162 1 1
RIPK2 PACRG 0 0 217 217 1 1
RIPK2 NIFK 0 0 0 216 1 1
RIPK2 SLC15A2 0 0 123 196 1 1
RIPK2 PDK2 0 0 0 197 1 1
RIPK2 GABARAPL1 0 0 95 172 1 2
RIPK2 GPR84 0 0 96 171 1 1
RIPK2 RHOA 0 0 156 243 1 2
RIPK2 HSPA8 117 0 83 255 1 2
RIPK2 BCLAF1 0 0 134 211 1 1
RIPK2 JUP 0 0 0 171 1 1
RIPK2 LLGL2 0 0 0 158 1 1
RIPK2 UBE2N 0 600 244 707 1 1
RIPK2 TLR5 0 0 406 435 1 1
RIPK2 ARHGEF2 0 800 251 850 1 1
RIPK2 PSMB8 0 0 90 183 1 1
RIPK2 SYNJ2BP 0 0 157 223 1 1
RIPK2 CD8A 0 0 240 251 1 1
RIPK2 FUNDC1 0 0 113 167 1 2
RIPK2 BIK 0 0 155 286 1 2
RIPK2 CRK 0 0 71 225 1 1
RIPK2 TICAM1 0 0 294 322 1 2
RIPK2 PELI3 270 0 113 453 1 1
RIPK2 BORCS8-MEF2B 0 0 139 297 1 1
RIPK2 NFKBIL1 0 0 134 225 1 1
RIPK2 NCBP1 0 0 0 158 1 1
RIPK2 YWHAE 0 0 0 165 1 1
RIPK2 ACAP1 0 0 264 303 1 1
RIPK2 APOL6 0 0 134 168 1 1
RIPK2 MIB2 0 0 74 332 1 1
RIPK2 CSNK1A1 0 0 181 255 1 1
RIPK2 BCL2L11 0 0 142 214 1 2
RIPK2 IL10RA 0 0 167 167 1 1
RIPK2 BRD3 0 0 167 307 1 1
RIPK2 MAPK12 0 650 163 740 1 1
RIPK2 RHOT1 0 0 0 288 1 1
RIPK2 RPL7 0 0 95 192 1 1
RIPK2 TMEM173 0 0 146 214 1 1
RIPK2 TNIP3 0 0 92 190 1 1
RIPK2 CASP1 270 0 902 929 1 2
RIPK2 TNFSF10 0 0 260 288 1 2
RIPK2 HLA-DRB1 0 0 155 154 1 1
RIPK2 HSPA1A 117 0 60 220 1 1
RIPK2 CDHR2 0 0 66 174 1 1
RIPK2 VRK2 0 0 56 181 1 1
RIPK2 MAP2K3 0 900 169 911 1 1
RIPK2 RPS6KA4 0 0 60 163 1 1
RIPK2 CASP9 0 0 357 394 1 2
RIPK2 ANXA13 0 0 0 248 1 1
RIPK2 RPS6KA3 0 0 95 156 1 1
RIPK2 MAPK9 0 800 270 864 1 2
RIPK2 TLR7 0 0 382 412 1 2
RIPK2 IL17A 0 0 278 278 1 2
RIPK2 RLTPR 0 0 67 161 1 1
RIPK2 NLRP5 0 0 138 233 1 1
RIPK2 ACVR1 0 0 341 173 1 1
RIPK2 GSKIP 0 0 0 159 1 1
RIPK2 STK16 0 0 225 242 1 1
RIPK2 DLG5 0 0 81 195 1 1
RIPK2 BPTF 0 0 0 302 1 1
RIPK2 PPP4R2 0 0 0 250 1 1
RIPK2 GNAS 0 0 0 158 1 1
RIPK2 DEFB103B 0 0 161 161 1 1
RIPK2 TRIB1 0 0 0 183 1 1
RIPK2 OTUB1 0 0 180 182 1 1
RIPK2 IFIH1 0 0 404 431 1 1
RIPK2 SPRED3 0 0 0 158 1 1
RIPK2 PARP8 0 0 0 175 1 1
RIPK2 ZNF385C 0 0 166 165 1 1
RIPK2 HSPA6 99 0 0 194 1 1
RIPK2 PTGER4 0 0 96 165 1 1
RIPK2 CISH 0 0 134 275 1 1
RIPK2 FKBP1A 0 0 229 250 1 2
RIPK2 DAPK3 0 0 107 176 1 2
RIPK2 SHANK2 0 0 0 161 1 1
RIPK2 GRAPL 0 0 0 170 1 1
RIPK2 USP36 0 0 92 191 1 1
RIPK2 RAPGEF1 0 0 0 185 1 1
RIPK2 HLA-DQA1 0 0 227 226 1 1
RIPK2 BCKDK 0 0 0 197 1 1
RIPK2 MAPKAPK2 0 0 117 227 1 1
RIPK2 YWHAG 0 0 0 165 1 1
RIPK2 SMG5 0 0 0 174 1 1
RIPK2 AIM2 0 0 375 375 1 2
RIPK2 DDX58 0 0 552 569 1 1
RIPK2 SNX15 0 0 0 204 1 1
RIPK2 BCL2L10 0 0 139 178 1 1
RIPK2 RNF31 270 800 418 912 1 1
RIPK2 LLGL1 0 0 0 158 1 1
RIPK2 MAVS 415 0 505 702 1 2
RIPK2 IL1A 0 0 351 381 1 1
RIPK2 SPAST 0 0 0 170 1 1
RIPK2 CCL4 0 0 181 198 1 1
RIPK2 CD276 0 0 90 170 1 1
RIPK2 ALG1L2 0 0 0 157 1 1
RIPK2 CASP8 213 900 391 951 1 2
RIPK2 KIF16B 0 0 0 173 1 1
RIPK2 PPM1G 0 0 0 209 1 1
RIPK2 TNFAIP8L2 0 0 67 187 1 1
RIPK2 RAD51AP2 0 0 0 213 1 1
RIPK2 PLEKHO1 0 0 74 336 1 1
RIPK2 USP28 0 0 47 153 1 1
RIPK2 SHQ1 0 0 145 176 1 1
RIPK2 CSNK2A2 0 0 90 170 1 1
RIPK2 TNFRSF10A 0 0 150 188 1 1
RIPK2 SLC46A2 0 0 94 157 1 1
RIPK2 CDK11B 0 0 0 163 1 1
RIPK2 RNF126 0 0 0 199 1 1
RIPK2 KARS 0 0 0 200 1 1
RIPK2 ANP32E 0 0 57 171 1 1
RIPK2 KDM7A 0 0 0 182 1 1
RIPK2 BMP2K 0 0 127 233 1 1
RIPK2 CAMKK2 0 0 122 153 1 2
RIPK2 SH3BP5 0 0 67 182 1 1
RIPK2 RPGR 0 0 0 159 1 1
RIPK2 LY86 0 0 108 203 1 1
RIPK2 TRIM23 0 0 49 176 1 1
RIPK2 GATA3 0 0 71 172 1 1
RIPK2 MKKS 0 0 155 243 1 1
RIPK2 ZNF675 0 0 139 174 1 1
RIPK2 ATP6V0D1 0 0 0 226 1 1
RIPK2 STAT3 0 0 235 318 1 2
RIPK2 IRF9 0 0 217 217 1 1
RIPK2 PRKCI 0 900 0 900 1 1
RIPK2 TTBK2 0 0 0 164 1 1
RIPK2 BNIP2 0 0 134 174 1 1
RIPK2 TRIM24 0 0 155 185 1 1
RIPK2 DDX54 0 0 74 152 1 1
RIPK2 FADD 0 900 391 941 1 2
RIPK2 ESX1 0 0 154 206 1 1
RIPK2 SARM1 0 0 284 319 1 1
RIPK2 METAP2 0 0 203 255 1 1
RIPK2 MYD88 0 900 561 962 1 2
RIPK2 PSTPIP1 0 0 137 169 1 1
RIPK2 CSF3 0 0 181 181 1 1
RIPK2 TRAF1 270 0 324 530 1 1
RIPK2 SLMAP 0 0 0 239 1 1
RIPK2 CRADD 0 0 537 544 1 1
RIPK2 NOL3 0 0 340 377 1 1
RIPK2 SMAD4 128 0 0 194 1 2
RIPK2 EFNA5 0 0 0 168 1 1
RIPK2 STXBP6 0 0 0 339 1 1
RIPK2 UBD 0 0 118 174 1 1
RIPK2 SHANK1 0 0 0 161 1 1
RIPK2 TAX1BP1 0 0 173 185 1 2
RIPK2 MAP2K5 0 0 166 228 1 1
RIPK2 NLRP10 0 0 249 248 1 1
RIPK2 WDR62 0 0 0 185 1 1
RIPK2 TLR1 0 0 401 484 1 1
RIPK2 NEGR1 0 0 70 170 1 1
RIPK2 ENSG00000272772 0 0 0 196 1 1
RIPK2 UCK1 0 0 0 171 1 1
RIPK2 CIDEA 0 0 124 164 1 1
RIPK2 PPP1R13B 0 0 0 155 1 1
RIPK2 BRD9 0 0 241 327 1 1
RIPK2 RBCK1 0 800 391 878 1 1
RIPK2 DSP 0 0 0 239 1 1
RIPK2 CD80 0 0 135 167 1 2
RIPK2 NLRP12 0 0 377 377 1 1
RIPK2 CARD10 0 0 235 371 1 1
RIPK2 CH25H 0 0 96 167 1 1
RIPK2 MAP2K1 0 0 163 227 1 1
RIPK2 VASP 0 0 55 491 1 1
RIPK2 IKZF3 0 0 142 257 1 1
RIPK2 DHX58 0 0 294 305 1 1
RIPK2 MYC 0 0 202 240 1 2
RIPK2 IRGM 0 0 374 379 1 2
RIPK2 PDK1 0 0 0 197 1 2
RIPK2 ARL8B 0 0 0 151 1 1
RIPK2 IL1R1 0 0 366 375 1 1
RIPK2 IL18 0 0 469 480 1 2
RIPK2 RXFP2 0 0 113 210 1 1
RIPK2 TAB2 270 800 558 934 1 2
RIPK2 UBE2D1 0 0 123 232 1 1
RIPK2 CORO6 0 0 0 162 1 1
RIPK2 STOML1 0 0 0 228 1 1
RIPK2 TAB1 270 800 392 921 1 1
RIPK2 GNAT3 0 0 0 177 1 1
RIPK2 TRAF2 629 800 632 973 1 2
RIPK2 CAMKMT 0 0 102 446 1 1
RIPK2 GNAT2 0 0 0 177 1 1
RIPK2 MED30 0 0 92 175 1 1
RIPK2 EFNA4 0 0 46 172 1 1
RIPK2 TAB3 0 800 295 862 1 1
RIPK2 CLEC7A 0 0 305 317 1 1
RIPK2 LONRF2 0 0 0 200 1 1
RIPK2 PAMR1 0 0 143 188 1 1
RIPK2 UHRF1 0 0 0 190 1 1
RIPK2 C1R 0 0 108 153 1 1
RIPK2 TUBB4A 117 0 55 156 1 1
RIPK2 BCL2L1 0 0 203 203 1 2
RIPK2 TLR4 213 0 520 625 1 2
RIPK2 RAB18 0 0 0 260 1 1
RIPK2 ATPAF1 0 0 66 182 1 1
RIPK2 ATIC 0 0 74 166 1 2
RIPK2 ABCF1 0 0 46 184 1 1
RIPK2 TNFRSF25 0 0 216 267 1 1
RIPK2 PTPN9 0 0 0 154 1 1
RIPK2 GABARAPL2 0 0 96 163 1 2
RIPK2 UBE2V2 0 0 0 195 1 1
RIPK2 NOS2 0 0 124 163 1 2
RIPK2 ELF1 0 0 0 159 1 1
RIPK2 CLIC6 0 0 0 193 1 1
RIPK2 NF1 0 0 46 159 1 1
RIPK2 KCNJ11 0 0 289 300 1 1
RIPK2 MAPK4 0 0 43 186 1 1
RIPK2 HSPA1L 118 0 0 205 1 1
RIPK2 PCSK7 0 0 0 150 1 1
RIPK2 BIRC2 753 900 741 993 1 1
RIPK2 IFNG 0 0 211 248 1 2
RIPK2 RGS8 0 0 63 210 1 1
RIPK2 TGFB3 0 0 56 163 1 1
RIPK2 CCL5 0 0 261 277 1 2
RIPK2 PLCG2 0 0 95 178 1 1
RIPK2 EPB41L3 0 0 0 195 1 1
RIPK2 ANXA5 0 0 95 173 1 2
RIPK2 HSPD1 0 0 77 173 1 1
RIPK2 PDP2 0 0 0 201 1 1
RIPK2 MAPKBP1 0 0 82 220 1 1
RIPK2 PLEC 0 0 0 178 1 1
RIPK2 PIDD1 0 0 134 277 1 1
RIPK2 TRAF4 270 0 344 544 1 1
RIPK2 CD40LG 0 0 203 215 1 1
RIPK2 NLRP1 0 0 504 504 1 1
RIPK2 MYSM1 0 0 90 202 1 1
RIPK2 RAB12 0 0 0 182 1 2
RIPK2 IL6 0 0 468 492 1 2
RIPK2 FRAT2 0 0 0 276 1 1
RIPK2 SBK1 0 0 142 204 1 1
RIPK2 BRD2 0 0 202 360 1 1
RIPK2 TNFRSF1A 270 0 501 637 1 1
RIPK2 TRAF5 270 800 390 911 1 1
RIPK2 HIF1A 0 0 154 185 1 2
RIPK2 IL1B 0 0 548 605 1 2
RIPK2 MAPK13 0 650 180 745 1 1
RIPK2 DOK7 0 0 0 175 1 1
RIPK2 RNF11 0 0 123 165 1 1
RIPK2 BEX1 0 900 96 905 1 1
RIPK2 GRIK3 0 0 0 150 1 1
RIPK2 CDK2 0 0 127 181 1 2
RIPK2 CSNK1G1 0 0 112 189 1 1
RIPK2 ERBB2IP 0 0 425 453 1 1
RIPK2 TNFRSF1B 0 0 171 222 1 1
RIPK2 VIL1 0 0 330 340 1 1
RIPK2 ATG12 0 0 327 337 1 2
RIPK2 PRKCQ 0 0 202 200 1 2
RIPK2 AAK1 0 0 171 205 1 1
RIPK2 NR2C2 0 0 161 200 1 1
RIPK2 IL33 0 0 217 217 1 2
RIPK2 CXCL1 0 0 323 357 1 2
RIPK2 TRIB3 0 0 66 184 1 2
RIPK2 LNX1 0 0 0 200 1 1
RIPK2 RPS6KC1 0 0 0 204 1 1
RIPK2 GNA15 0 0 42 159 1 1
RIPK2 PGLYRP1 0 0 161 185 1 1
RIPK2 DAXX 0 900 113 909 1 1
RIPK2 IL1RL1 0 0 112 173 1 1
RIPK2 TNFRSF21 0 0 167 293 1 1
RIPK2 YWHAH 0 0 48 171 1 1
RIPK2 NFU1 0 0 0 167 1 1
RIPK2 CSF1 0 0 150 200 1 1
RIPK2 EGFLAM 0 0 0 155 1 1
RIPK2 CASP4 0 0 252 314 1 2
RIPK2 STAMBPL1 0 0 130 152 1 1
RIPK2 SOCS2 0 0 103 160 1 1
RIPK2 SFN 0 0 0 165 1 2
RIPK2 SLC11A1 0 0 326 425 1 1
RIPK2 ITGAX 0 0 161 190 1 1
RIPK2 SIK1 0 0 150 161 1 1
RIPK2 PBRM1 0 0 0 167 1 1
RIPK2 CUL3 0 0 62 162 1 2
RIPK2 CHUK 270 900 539 941 1 1
RIPK2 SH2D1A 0 0 77 191 1 1
RIPK2 NLRP11 0 0 203 242 1 1
RIPK2 HSPA5 0 0 62 489 1 2
RIPK2 CHMP5 0 0 95 292 1 1
RIPK2 CASP14 0 0 208 240 1 1
RIPK2 MYO3B 0 0 0 171 1 1
RIPK2 BTRC 0 0 81 162 1 1
RIPK2 FOXO1 0 0 81 154 1 2
RIPK2 CDK9 0 0 213 160 1 1
RIPK2 SMS 0 0 108 245 1 1
RIPK2 IFNGR1 0 0 171 184 1 1
RIPK2 SOD2 62 0 61 164 1 2
RIPK2 YWHAZ 0 0 52 174 1 1
RIPK2 PPM1N 0 0 0 198 1 1
RIPK2 RAB30 0 0 62 222 1 1
RIPK2 FOS 0 0 181 205 1 2
RIPK2 PSME2 0 0 81 155 1 1
RIPK2 IRG1 0 0 143 215 1 1
RIPK2 OSBPL11 0 0 95 295 1 1
RIPK2 PTPN11 0 0 64 151 1 1
RIPK2 CRKL 0 0 66 295 1 1
RIPK2 SHARPIN 0 800 403 880 1 1
RIPK2 CLIC1 0 0 0 150 1 1
RIPK2 ARHGAP35 0 0 0 172 1 1
RIPK2 UGP2 0 0 0 162 1 1
RIPK2 NOD1 871 800 989 999 1 2
RIPK2 GNAI3 0 0 0 178 1 2
RIPK2 MALRD1 0 0 0 190 1 1
RIPK2 GRID2 0 0 0 150 1 2
RIPK2 OTUD7B 0 0 137 182 1 1
RIPK2 CCL7 0 0 193 208 1 1
RIPK2 EIF4EBP2 0 0 0 278 1 1
RIPK2 EPYC 0 0 0 188 1 1
RIPK2 TLR2 213 0 561 665 1 2
RIPK2 PMAIP1 0 0 135 160 1 2
RIPK2 PIM3 0 0 60 179 1 1
RIPK2 ANKRD45 0 0 0 175 1 1
RIPK2 TRAF3 270 800 963 994 1 2
RIPK2 MET 0 0 156 221 1 2
RIPK2 GNAO1 0 0 0 177 1 1
RIPK2 TOLLIP 0 0 240 298 1 1
RIPK2 LRRK2 270 0 379 464 1 2
RIPK2 DCP1B 0 0 0 239 1 1
RIPK2 MAP3K5 0 0 194 217 1 1
RIPK2 ITGAM 0 0 181 210 1 1
RIPK2 RGS1 0 0 122 223 1 1
RIPK2 GNA11 0 0 0 177 1 1
RIPK2 IRF5 0 0 284 307 1 1
RIPK2 HMGB1 0 0 243 256 1 2
RIPK2 RAC1 0 0 81 175 1 2
RIPK2 MAPK6 0 0 67 206 1 1
RIPK2 CTSB 0 0 142 158 1 2
RIPK2 AURKAIP1 0 0 0 183 1 1
RIPK2 MAPK8IP3 0 0 134 341 1 1
RIPK2 KRT31 0 0 66 170 1 1
RIPK2 DPM1 0 0 0 153 1 1
RIPK2 MCL1 0 0 151 150 1 2
RIPK2 STAT2 0 0 257 353 1 1
RIPK2 XBP1 0 0 143 165 1 2
RIPK2 PUM1 0 0 0 187 1 1
RIPK2 PTPN1 0 0 87 205 1 1
RIPK2 ATG5 0 0 438 449 1 2
RIPK2 MAP2K6 0 900 113 906 1 1
RIPK2 TMPRSS11F 0 0 148 161 1 1
RIPK2 TLR8 0 0 280 316 1 1
RIPK2 BCL2L14 0 0 113 185 1 1
RIPK2 ISG15 0 0 95 152 1 2
RIPK2 MAMDC4 0 0 0 190 1 1
RIPK2 NFKBIB 0 0 182 324 1 1
RIPK2 SUGT1 0 0 193 258 1 1
RIPK2 USP18 0 0 113 167 1 1
RIPK2 DYRK1A 0 0 81 170 1 1
RIPK2 URGCP 0 0 357 357 1 1
RIPK2 PARD6B 0 0 54 200 1 1
RIPK2 RALA 0 0 74 216 1 1
RIPK2 MAP4K4 0 0 174 254 1 1
RIPK2 IKBKG 486 900 958 997 1 1
RIPK2 DEDD2 0 0 193 193 1 1
RIPK2 CXCR5 0 0 0 201 1 1
RIPK2 SH3BP5L 0 0 0 165 1 1
RIPK2 RPS6KA1 0 0 150 177 1 1
RIPK2 MAP3K12 0 0 46 179 1 1
RIPK2 NEK2 0 0 0 151 1 1
RIPK2 GNPTG 0 0 66 345 1 1
RIPK2 NBN 0 0 0 184 1 1
RIPK2 GNAI1 0 0 0 178 1 1
RIPK2 ENSG00000267261 0 0 0 178 1 1
RIPK2 TUBGCP2 0 0 0 198 1 1
RIPK2 PLEKHG4B 0 0 0 184 1 1
RIPK2 NCK1 0 0 46 150 1 1
RIPK2 FMN1 0 0 0 175 1 1
RIPK2 CCL20 0 0 253 272 1 1
RIPK2 CDK7 0 0 146 200 1 1
RIPK2 EFNB2 0 0 0 168 1 1
RIPK2 CXCL2 0 0 303 339 1 1
RIPK2 TRAT1 0 0 155 154 1 1
RIPK2 USP34 0 0 0 166 1 1
RIPK2 ATG7 0 0 436 469 1 2
RIPK2 IKZF1 0 0 123 190 1 1
RIPK2 ACTG1 118 0 75 192 1 1
RIPK2 TRAF7 0 0 202 312 1 1
RIPK2 CASP5 0 0 414 439 1 1
RIPK2 RPS6KL1 0 0 0 155 1 1
RIPK2 PRKAA2 0 0 0 158 1 2
RIPK2 IRF4 270 0 181 421 1 1
RIPK2 MAPK7 0 0 97 185 1 1
RIPK2 STXBP5L 0 0 0 158 1 1
RIPK2 GABARAP 0 0 113 189 1 2
RIPK2 STX11 0 0 62 162 1 1
RIPK2 MAPK14 0 650 322 789 1 2
RIPK2 MAPK10 0 800 160 844 1 2
RIPK2 TP53BP2 0 0 57 223 1 2
RIPK2 SARNP 0 0 0 154 1 1
RIPK2 ZC3H12A 0 0 150 225 1 1
RIPK2 ATAD2B 0 0 0 175 1 1
RIPK2 CLIC4 0 0 0 150 1 1
RIPK2 NFKBIA 0 0 503 565 1 2
RIPK2 RHOT2 0 0 46 377 1 1
RIPK2 SYK 0 0 265 219 1 2
RIPK2 NR1D1 0 0 68 161 1 2
RIPK2 PPP2R5E 0 0 66 187 1 1
RIPK2 MAP2K2 0 0 135 217 1 1
RIPK2 PHLPP2 0 0 0 162 1 1
RIPK2 EVL 0 0 0 158 1 1
RIPK2 EFNA1 0 0 0 168 1 1
RIPK2 UAP1 0 0 0 169 1 1
RIPK2 CARD18 0 0 321 336 1 1
RIPK2 DFFA 0 0 218 252 1 1
RIPK2 TSSK2 0 0 0 158 1 1
RIPK2 CENPK 0 0 0 157 1 1
RIPK2 ANK2 0 0 0 159 1 1
RIPK2 CCNK 0 0 147 216 1 1
RIPK2 ENSG00000258973 0 0 0 162 1 1
RIPK2 INADL 0 0 0 159 1 1
RIPK2 GRIK5 0 0 0 150 1 1
RIPK2 NDUFA13 0 0 243 242 1 1
RIPK2 RRAD 0 0 67 198 1 1
RIPK2 PIK3C2B 0 0 48 212 1 1
RIPK2 IFT43 0 0 273 273 1 1
RIPK2 PRKDC 0 0 69 161 1 2
RIPK2 PPP2CA 0 0 44 179 1 1
RIPK2 YWHAQ 0 0 0 165 1 1
RIPK2 BAD 0 0 61 155 1 2
RIPK2 PPM1K 0 0 0 198 1 1
RIPK2 TACC3 0 0 107 194 1 1
RIPK2 LRGUK 0 0 0 161 1 1
RIPK2 LOXL1 0 0 0 216 1 1
RIPK2 PRKAA1 0 0 0 158 1 2
RIPK2 IFIT2 0 0 120 169 1 1
RIPK2 SIGLEC10 0 0 53 198 1 1
RIPK2 UBE2I 180 0 53 212 1 1
RIPK2 IRAK2 0 600 391 664 1 1
RIPK2 ANXA2 0 0 0 208 1 1
RIPK2 TNFSF14 0 0 181 199 1 1
RIPK2 FNBP1L 0 0 101 189 1 1
RIPK2 BCL2A1 0 0 236 279 1 1
RIPK2 RELB 0 0 213 245 1 2
RIPK2 ITSN2 0 0 66 202 1 1
RIPK2 CXCL3 0 0 229 271 1 1
RIPK2 IREB2 0 0 81 180 1 1
RIPK2 PPTC7 0 0 0 198 1 1
RIPK2 IFNAR1 0 0 219 267 1 1
RIPK2 CUL4B 0 0 0 155 1 1
RIPK2 BTK 0 0 294 177 1 1
RIPK2 SOCS1 0 0 148 251 1 1
RIPK2 RFXANK 0 0 242 527 1 1
RIPK2 LIMD2 0 0 0 169 1 1
RIPK2 EFNA3 0 0 0 168 1 1
RIPK2 DEFB4A 0 0 181 181 1 1
RIPK2 CSF1R 0 0 112 151 1 1
RIPK2 MAPK1 0 0 167 208 1 2
RIPK2 CSNK1G3 0 0 74 154 1 1
RIPK2 PPP2R5C 0 0 0 174 1 1
RIPK2 CCT2 0 0 0 164 1 1
RIPK2 GADD45A 0 0 166 459 1 1
RIPK2 CASP2 0 0 442 476 1 1
RIPK2 GNAI2 0 0 0 177 1 1
RIPK2 BDNF 0 0 97 150 1 2
RIPK2 HSPA2 115 0 0 202 1 1
RIPK2 TIRAP 0 0 385 396 1 1
RIPK2 PRDM5 0 0 53 169 1 1
RIPK2 CDK12 0 0 90 177 1 1
RIPK2 TANK 0 0 285 344 1 2
RIPK2 SDK2 0 0 0 171 1 1
RIPK2 EYA3 0 0 0 170 1 1
RIPK2 TSSK1B 0 0 0 158 1 1
RIPK2 IL23R 0 0 289 301 1 1
RIPK2 ABI2 0 0 0 257 1 1
RIPK2 BAG4 0 0 93 262 1 1
RIPK2 MAP3K15 0 0 0 161 1 1
RIPK2 VCAM1 0 0 137 156 1 1
RIPK2 WDTC1 0 0 0 164 1 1
RIPK2 MBTPS1 0 0 307 334 1 1
RIPK2 FAS 0 900 208 919 1 2
RIPK2 CDK18 0 0 74 174 1 1
RIPK2 F13A1 0 0 112 203 1 1
RIPK2 GRIK1 0 0 0 150 1 1
RIPK2 EFNB3 0 0 0 168 1 1
RIPK2 CSF2 0 0 243 259 1 1
RIPK2 CTDP1 0 0 0 161 1 1
RIPK2 TMED10 0 0 0 164 1 1
RIPK2 TRHDE 0 0 188 412 1 1
RIPK2 SDHD 0 0 0 424 1 1
RIPK2 DNAJB14 0 0 90 166 1 1
RIPK2 KRT83 0 0 91 185 1 1
RIPK2 NLRC4 0 0 643 643 1 2
RIPK2 KRTAP9-4 0 0 125 195 1 1
RIPK2 ATP7A 0 0 263 348 1 1
RIPK2 USP25 0 0 96 162 1 1
RIPK2 ADRM1 0 0 60 177 1 1
RIPK2 PHF20 0 0 181 205 1 1
RIPK2 CYLD 0 900 340 941 1 1
RIPK2 GRIK4 0 0 0 150 1 1
RIPK2 HSP90AB1 0 800 94 837 1 2
RIPK2 TCEB2 0 0 117 154 1 1
RIPK2 PINK1 0 0 117 164 1 2
RIPK2 UBQLN1 0 0 62 189 1 1
RIPK2 PPM1E 0 0 0 198 1 1
RIPK2 NGF 0 900 143 912 1 2
RIPK2 DDR1 0 0 274 187 1 1
RIPK2 GRK5 0 0 76 156 1 1
RIPK2 PRKRA 0 0 118 243 1 1
RIPK2 CARD6 486 800 736 971 1 1
RIPK2 TNFSF8 0 0 181 208 1 1
RIPK2 CDC42 0 0 150 237 1 2
RIPK2 UAP1L1 0 0 0 169 1 1
RIPK2 IRF8 0 0 240 267 1 1
RIPK2 FOXO3 0 0 91 163 1 2
RIPK2 CD180 0 0 202 270 1 1
RIPK2 ATG3 0 0 107 189 1 2
RIPK2 TMPRSS11E 0 0 90 196 1 1
RIPK2 CORO1A 0 0 0 162 1 1
RIPK2 BIRC6 0 0 217 364 1 1
RIPK2 BNIP1 0 0 123 183 1 2
RIPK2 ANKRD17 0 0 0 172 1 1
RIPK2 TLR3 0 0 429 457 1 2
RIPK2 KDR 0 0 113 187 1 2
RIPK2 SKP1 0 0 118 164 1 2
RIPK2 RAC2 0 0 112 203 1 1
RIPK2 PARD6G 0 0 0 189 1 1
RIPK2 MBD5 0 0 134 308 1 1
RIPK2 ARHGAP32 0 0 0 152 1 1
RIPK2 DYNLRB1 0 0 114 263 1 1
RIPK2 CLEC5A 0 0 171 236 1 1
RIPK2 CCDC88B 0 0 74 198 1 1
RIPK2 CORO2A 0 0 0 162 1 1
RIPK2 PRKD2 0 0 0 167 1 1
RIPK2 TBK1 0 0 464 497 1 2
RIPK2 PTPN6 0 0 134 214 1 1
RIPK2 FOXP3 0 0 161 228 1 2
RIPK2 POP4 0 0 0 184 1 1
RIPK2 PRKD3 0 0 179 403 1 1
RIPK2 MAP3K6 0 0 0 161 1 1
RIPK2 PRKCD 0 0 136 175 1 2
RIPK2 UBR1 0 0 0 193 1 1
RIPK2 CLK4 0 0 54 152 1 1
RIPK2 NKX1-2 0 0 82 257 1 1
RIPK2 RIPK3 0 0 470 221 1 2
RIPK2 TGFB1 0 0 48 194 1 2
RIPK2 PIK3C2A 0 0 0 181 1 1
RIPK2 LRIT3 0 0 0 165 1 1
RIPK2 STAT5B 0 0 81 181 1 1
RIPK2 ALG2 0 0 0 157 1 1
RIPK2 NLRX1 0 0 391 401 1 2
RIPK2 GRAP2 0 0 0 170 1 1
RIPK2 GNA14 0 0 0 181 1 1
RIPK2 SQSTM1 0 900 181 920 1 2
RIPK2 BNIP3 0 0 146 235 1 2
RIPK2 ANXA4 0 0 0 258 1 1
RIPK2 SLC11A2 0 0 54 193 1 1
RIPK2 FAR1 0 0 67 165 1 1
RIPK2 MAPK3 0 0 291 254 1 2
RIPK2 HSP90AA1 118 800 686 948 1 2
RIPK2 BCL3 0 0 0 177 1 1
RIPK2 TP73 0 0 139 288 1 2
RIPK2 RHOV 0 0 54 151 1 1
RIPK2 PTPRC 0 0 162 213 1 1
RIPK2 BCL10 213 900 459 956 1 1
RIPK2 UBE2G2 0 0 0 160 1 1
RIPK2 HUNK 0 0 0 158 1 1
RIPK2 WDR48 0 0 43 168 1 1
RIPK2 RALB 0 0 96 253 1 2
RIPK2 ICAM1 0 0 178 195 1 2
RIPK2 IGDCC3 0 0 0 184 1 1
RIPK2 SGMS1 0 0 95 174 1 1
RIPK2 RNF8 0 0 0 239 1 1
RIPK2 KRTAP3-1 0 0 95 235 1 1
RIPK2 AR 0 0 182 212 1 2
RIPK2 FGL2 0 0 0 211 1 1
RIPK2 BID 0 0 143 376 1 2
RIPK2 ENSG00000249884 0 0 0 180 1 1
RIPK2 GNA12 0 0 0 194 1 1
RIPK2 SLC15A1 0 0 233 365 1 1
RIPK2 CCDC122 0 0 637 644 1 1
RIPK2 PUM2 0 0 0 172 1 1
RIPK2 IRS2 0 0 113 203 1 1
RIPK2 BMP6 0 0 64 170 1 1
RIPK2 CLIP4 0 0 0 163 1 1
RIPK2 KRT34 0 0 73 254 1 1
RIPK2 PPM1F 0 0 0 198 1 1
RIPK2 TBXAS1 0 0 0 201 1 1
RIPK2 EYS 0 0 0 181 1 1
RIPK2 NFKBIE 0 0 142 299 1 1
RIPK2 GRB2 0 0 90 213 1 1
RIPK2 ABI1 0 0 0 328 1 1
RIPK2 LRIT1 0 0 0 165 1 1
RIPK2 PP2D1 0 0 0 198 1 1
RIPK2 ASIP 0 0 67 163 1 1
RIPK2 CLEC6A 0 0 166 180 1 1
RIPK2 ANKHD1 0 0 70 199 1 1
RIPK2 LTA 0 0 150 212 1 1
RIPK2 ANKRD44 0 0 0 203 1 1
RIPK2 CORO2B 0 0 0 162 1 1
RIPK2 DIDO1 0 0 74 339 1 1
RIPK2 ENSG00000173366 0 0 377 416 1 1
RIPK2 TRIO 0 0 0 172 1 1
RIPK2 JUN 0 0 341 366 1 2
RIPK2 ETNK2 0 0 0 159 1 1
RIPK2 CLIC5 0 0 0 150 1 1
RIPK2 DAPK1 0 0 181 172 1 2
RIPK2 FUT2 0 0 173 194 1 1
RIPK2 MYO3A 0 0 0 156 1 1
RIPK2 TEX2 0 0 91 187 1 1
RIPK2 CRTC3 0 0 132 200 1 1
RIPK2 TRIM38 0 0 95 165 1 1
RIPK2 SIK2 0 0 164 156 1 1
RIPK2 SPRYD7 0 0 415 421 1 1
RIPK2 STXBP5 0 0 0 158 1 1
RIPK2 TRAF6 675 900 656 988 1 2
RIPK2 GADD45B 0 0 77 219 1 1
RIPK2 CYCS 0 0 167 168 1 2
RIPK2 DUSP12 0 0 83 317 1 1
RIPK2 PPM1L 0 0 71 237 1 1
RIPK2 CXCL11 0 0 164 200 1 1
RIPK2 PDP1 0 0 0 201 1 1
RIPK2 GNAZ 0 0 0 177 1 1
RIPK2 BMP2 0 0 48 156 1 1
RIPK2 GAK 0 0 380 285 1 1
RIPK2 PELI1 0 0 244 357 1 1
RIPK2 BFAR 0 0 162 245 1 1
RIPK2 PCSK1 0 0 101 154 1 1
RIPK2 IRF2 0 0 166 176 1 1
RIPK2 HSPA4 0 0 138 226 1 1
RIPK2 KCNH6 0 0 63 194 1 1
RIPK2 PDZD2 0 0 0 159 1 1
RIPK2 PIK3R1 0 0 113 298 1 1
RIPK2 DYRK3 0 0 72 235 1 1
RIPK2 ALPK1 0 0 137 372 1 1
RIPK2 HSP90B1 0 800 57 846 1 1
RIPK2 CCR2 0 0 140 153 1 2
RIPK2 PPARA 0 0 100 187 1 2
RIPK2 IER3 0 0 96 158 1 1
RIPK2 CXCL9 0 0 171 189 1 1
RIPK2 TUFM 0 0 150 237 1 2
RIPK2 SSH1 0 0 85 183 1 1
RIPK2 SPATA2 0 0 252 252 1 1
RIPK2 DIABLO 0 0 265 294 1 2
RIPK2 P2RX7 0 0 151 150 1 2
RIPK2 BAZ1B 0 0 0 153 1 1
RIPK2 CHKA 0 0 43 160 1 1
RIPK2 MBTPS2 0 0 350 367 1 1
RIPK2 PPP2CB 0 0 0 151 1 1
RIPK2 CCR1 0 0 165 178 1 1
RIPK2 MAPK8 0 800 275 866 1 2
RIPK2 ATP6V0D2 0 0 0 304 1 1
RIPK2 MAP2K4 0 900 184 910 1 1
RIPK2 CLIC2 0 0 0 150 1 1
RIPK2 HSPA14 0 0 50 222 1 1
RIPK2 SGK494 0 0 0 195 1 1
RIPK2 VPS35 0 0 0 171 1 2
RIPK2 MB21D1 0 0 245 261 1 1
RIPK2 DUSP10 0 0 0 165 1 1
RIPK2 PRKCZ 0 900 75 901 1 1
RIPK2 RAB32 0 0 142 176 1 2
RIPK2 GLMN 0 0 74 151 1 1
RIPK2 GTPBP1 0 0 0 213 1 1
RIPK2 KLHL6 0 0 134 166 1 1
RIPK2 GBP1 0 0 113 192 1 1
RIPK2 TRADD 0 0 391 400 1 1
RIPK2 ALK 0 0 96 198 1 2
RIPK2 OTULIN 0 0 426 430 1 1
RIPK2 NAA50 0 0 60 213 1 1
RIPK2 CARD17 0 0 218 252 1 1
RIPK2 CTR9 0 0 71 151 1 1
RIPK2 CCL2 0 0 335 347 1 2
RIPK2 ANXA3 0 0 0 245 1 1
RIPK2 KRT71 0 0 80 234 1 1
RIPK2 DUSP7 0 0 46 258 1 1
RIPK2 CSNK1D 0 0 122 269 1 1
RIPK2 CUL1 0 0 72 190 1 1
RIPK2 CASP7 0 0 202 458 1 1
RIPK2 CDK5 0 0 124 150 1 2
RIPK2 LGALS8 0 0 141 162 1 1
RIPK2 PDGFRB 0 0 103 178 1 2
RIPK2 NUMB 0 0 0 178 1 1
RIPK2 IL4 0 0 247 246 1 1
RIPK2 BIRC3 675 900 439 982 1 1
RIPK2 IL17F 0 0 155 169 1 1
RIPK2 SMAD3 0 0 95 161 1 2
RIPK2 TARBP2 0 0 0 177 1 1
RIPK2 C19orf24 0 0 0 168 1 1
RIPK2 NGFRAP1 0 0 193 193 1 1
RIPK2 NLRC5 0 0 391 404 1 1
RIPK2 TP53RK 0 0 113 275 1 1
RIPK2 GNAT1 0 0 0 177 1 1
RIPK2 APAF1 0 0 550 583 1 2
RIPK2 BRD4 0 0 262 354 1 2
RIPK2 CALM3 117 0 0 173 1 1
RIPK2 MELK 0 0 122 190 1 1
RIPK2 FHOD3 0 0 0 163 1 1
RIPK2 PTPN22 0 0 150 233 1 1
RIPK2 RHBDL3 0 0 0 166 1 1
RIPK2 ETNK1 0 0 0 159 1 1
RIPK2 STEAP4 0 0 170 313 1 1
RIPK2 DEPDC4 0 0 0 161 1 1
RIPK2 TP53 0 0 195 207 1 2
RIPK2 MDM2 0 0 152 165 1 2
RIPK2 RASGRP1 0 0 45 183 1 1
RIPK2 ANKFY1 0 0 0 182 1 1
RIPK2 TSLP 0 0 218 218 1 1
RIPK2 DEFB103A 0 0 161 161 1 1
RIPK2 MAP3K13 0 0 44 178 1 1
RIPK2 CFLAR 270 900 527 964 1 2
RIPK2 EGFR 0 0 205 173 1 2
RIPK2 IRAK1 213 900 457 932 1 1
RIPK2 FHOD1 0 0 0 163 1 1
RIPK2 VRK3 0 0 0 164 1 1
RIPK2 CUL2 0 0 112 240 1 1
RIPK2 CARD9 0 800 648 935 1 1
RIPK2 PPP2R5D 0 0 0 168 1 1
RIPK2 NLRP4 0 0 256 271 1 1
RIPK2 MAP3K7 835 600 697 949 1 2
RIPK2 NFKBIZ 0 0 174 281 1 1
RIPK2 EDA 0 0 0 295 1 1
RIPK2 KRTAP9-3 0 0 124 260 1 1
RIPK2 CASP10 0 900 141 915 1 1
RIPK2 IL1RL2 0 0 163 232 1 1
RIPK2 DUSP4 0 0 62 163 1 1
RIPK2 ZNRF4 270 0 207 406 1 1
RIPK2 ALG11 0 0 0 157 1 1
RIPK2 OASL 0 0 150 245 1 1
RIPK2 STK11 0 0 0 174 1 2
RIPK2 MAP3K8 0 0 137 214 1 1
RIPK2 OPA1 0 0 0 155 1 2
RIPK2 IL15 0 0 150 183 1 1
RIPK2 UCK2 0 0 0 171 1 1
RIPK2 CBLB 0 0 0 296 1 1
RIPK2 PPP5C 0 0 0 157 1 1
RIPK2 PARK2 0 0 213 262 1 1
RIPK2 IFNA1 0 0 261 261 1 1
RIPK2 APC2 0 0 0 151 1 1
RIPK2 ABI3 0 0 0 190 1 1
RIPK2 SLC15A4 0 0 322 344 1 1
RIPK2 PIM1 0 0 0 180 1 1
RIPK2 MEFV 0 0 556 563 1 1
RIPK2 PIK3R3 0 0 0 241 1 1
RIPK2 GNAQ 0 0 0 158 1 1
RIPK2 WDR64 0 0 0 176 1 1
RIPK2 USP15 0 0 112 151 1 1
RIPK2 TRIM25 0 0 218 276 1 1
RIPK2 STAT4 0 900 113 918 1 1
RIPK2 CASP6 0 0 181 271 1 1
RIPK2 ZAP70 0 0 113 225 1 1
RIPK2 TLR10 0 0 202 311 1 1
RIPK2 NFKB1 0 0 324 472 1 2
RIPK2 KLF6 0 0 57 176 1 1
RIPK2 RELA 0 0 323 358 1 2
RIPK2 RAB33B 0 0 53 152 1 2
RIPK2 BNIPL 0 0 0 173 1 1
RIPK2 DUSP5 0 0 103 233 1 1
RIPK2 ALG1L 0 0 0 157 1 1
RIPK2 GAPDH 102 0 266 341 1 2
RIPK2 TNFSF15 0 0 417 451 1 1
RIPK2 ARL5B 0 0 54 151 1 1
RIPK2 OAS2 0 0 166 165 1 1
RIPK2 CD83 0 0 73 171 1 1
RIPK2 TSSK3 0 0 0 162 1 1
RIPK2 MAP2K7 0 900 113 911 1 1
RIPK2 CLUAP1 0 0 0 211 1 1
RIPK2 UBE2D3 0 0 150 348 1 1
RIPK2 ESRRA 0 0 308 515 1 1
RIPK2 CREBBP 0 0 0 167 1 1
RIPK2 RHOBTB2 0 0 53 150 1 1
RIPK2 CKAP5 0 0 0 155 1 1
RIPK2 TNP1 0 0 309 309 1 1
RIPK2 P3R3URF 0 0 0 239 1 1
RIPK2 WWP1 0 0 56 487 1 1
RIPK2 GZMM 0 0 263 274 1 1
RIPK2 APC 0 0 0 151 1 1
RIPK2 CREB1 0 0 132 152 1 2
RIPK2 GSDMD 0 0 181 204 1 2
RIPK2 EFNB1 0 0 0 168 1 1
RIPK2 USP9X 0 0 53 229 1 1
RIPK2 ARL14 0 0 89 183 1 1
RIPK2 LAMTOR5 0 0 0 189 1 1
RIPK2 GRID2IP 0 0 0 260 1 1
RIPK2 GRIK2 0 0 0 150 1 1
RIPK2 NRBP2 0 0 156 221 1 1
RIPK2 CXCR4 0 0 123 172 1 2
RIPK2 TRIB2 0 0 0 162 1 1
RIPK2 MTOR 0 0 124 216 1 2
RIPK2 ANXA11 0 0 0 242 1 1
RIPK2 PIK3C3 0 0 135 292 1 2
RIPK2 NLRC3 0 0 392 411 1 1
RIPK2 GSPT1 0 0 150 180 1 1
RIPK2 PPP4C 0 0 0 206 1 1
RIPK2 CLK3 0 0 63 159 1 1
RIPK2 TCF20 0 0 234 320 1 1
RIPK2 GNA13 0 0 0 215 1 1
RIPK2 CXCL14 0 0 46 210 1 1
RIPK2 STAT1 0 0 286 381 1 2
RIPK2 TRIM27 0 0 247 259 1 1
RIPK2 BAG3 0 0 150 203 1 2
RIPK2 VRK1 0 0 54 175 1 1
RIPK2 CXCL8 0 0 459 505 1 2
RIPK2 POLR2C 0 0 0 160 1 1
RIPK2 UBE2G1 0 0 52 151 1 1
RIPK2 RBM5 0 0 46 159 1 1
RIPK2 HRAS 0 0 73 189 1 2
RIPK2 CTNNB1 0 0 103 526 1 2
RIPK2 DCAF6 0 0 0 164 1 1
RIPK2 EGR1 0 0 122 158 1 2
RIPK2 ARL8A 0 0 0 151 1 1
RIPK2 ALG1 0 0 0 157 1 1
RIPK2 LACC1 0 0 601 612 1 1
RIPK2 PASK 0 0 0 158 1 1
RIPK2 IGSF9B 0 0 0 156 1 1
RIPK2 IKBKE 0 0 233 293 1 1
RIPK2 N4BP2L1 0 0 107 220 1 1
RIPK2 SMC2 0 0 45 183 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005524 Molecular Function ATP binding enables IEA
GO:0050700 Molecular Function CARD domain binding enables IDA
GO:0050700 Molecular Function CARD domain binding enables IPI
GO:0004706 Molecular Function JUN kinase kinase kinase activity enables IBA
GO:0030274 Molecular Function LIM domain binding enables IPI
GO:0089720 Molecular Function caspase binding enables IPI
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0004715 Molecular Function non-membrane spanning protein tyrosine kinase activity enables IEA
GO:0005515 Molecular Function protein binding enables IPI
GO:0042803 Molecular Function protein homodimerization activity enables IDA
GO:0106310 Molecular Function protein serine kinase activity enables IEA
GO:0004674 Molecular Function protein serine/threonine kinase activity enables ISS
GO:0004674 Molecular Function protein serine/threonine kinase activity enables TAS
GO:0035591 Molecular Function signaling adaptor activity enables IDA
GO:0005102 Molecular Function signaling receptor binding enables IPI
GO:0035739 Biological Process CD4-positive, alpha-beta T cell proliferation involved_in IEA
GO:0070371 Biological Process ERK1 and ERK2 cascade involved_in IEA
GO:0007254 Biological Process JNK cascade involved_in IEA
GO:0050852 Biological Process T cell receptor signaling pathway involved_in ISS
GO:0050852 Biological Process T cell receptor signaling pathway involved_in TAS
GO:0097202 Biological Process activation of cysteine-type endopeptidase activity involved_in IDA
GO:0002250 Biological Process adaptive immune response involved_in ISS
GO:0006915 Biological Process apoptotic process involved_in IDA
GO:0007249 Biological Process canonical NF-kappaB signal transduction involved_in ISS
GO:0071223 Biological Process cellular response to lipoteichoic acid involved_in IEA
GO:0071225 Biological Process cellular response to muramyl dipeptide involved_in IDA
GO:0071224 Biological Process cellular response to peptidoglycan involved_in IEA
GO:0019221 Biological Process cytokine-mediated signaling pathway involved_in IEA
GO:0050830 Biological Process defense response to Gram-positive bacterium involved_in IEA
GO:0042742 Biological Process defense response to bacterium involved_in IDA
GO:0033080 Biological Process immature T cell proliferation in thymus involved_in IEA
GO:0006954 Biological Process inflammatory response involved_in TAS
GO:0045087 Biological Process innate immune response involved_in IBA
GO:0045087 Biological Process innate immune response involved_in IDA
GO:0045087 Biological Process innate immune response involved_in ISS
GO:0031663 Biological Process lipopolysaccharide-mediated signaling pathway involved_in IEA
GO:0070427 Biological Process nucleotide-binding oligomerization domain containing 1 signaling pathway involved_in IDA
GO:0070431 Biological Process nucleotide-binding oligomerization domain containing 2 signaling pathway involved_in IDA
GO:0016310 Biological Process phosphorylation involved_in IEA
GO:2000563 Biological Process positive regulation of CD4-positive, alpha-beta T cell proliferation involved_in IEA
GO:0070374 Biological Process positive regulation of ERK1 and ERK2 cascade involved_in IEA
GO:0046330 Biological Process positive regulation of JNK cascade involved_in IEA
GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IDA
GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IMP
GO:0045627 Biological Process positive regulation of T-helper 1 cell differentiation involved_in IEA
GO:0002827 Biological Process positive regulation of T-helper 1 type immune response involved_in IEA
GO:0043065 Biological Process positive regulation of apoptotic process involved_in IEA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IBA
GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction acts_upstream_of_or_within IDA
GO:0032722 Biological Process positive regulation of chemokine production involved_in IEA
GO:0001961 Biological Process positive regulation of cytokine-mediated signaling pathway involved_in IEA
GO:0033092 Biological Process positive regulation of immature T cell proliferation in thymus involved_in IEA
GO:0032727 Biological Process positive regulation of interferon-alpha production involved_in NAS
GO:0032728 Biological Process positive regulation of interferon-beta production involved_in NAS
GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in IDA
GO:0032735 Biological Process positive regulation of interleukin-12 production involved_in NAS
GO:0032743 Biological Process positive regulation of interleukin-2 production involved_in IEA
GO:0032755 Biological Process positive regulation of interleukin-6 production involved_in IEA
GO:0060907 Biological Process positive regulation of macrophage cytokine production involved_in IEA
GO:0033138 Biological Process positive regulation of peptidyl-serine phosphorylation involved_in IDA
GO:0010800 Biological Process positive regulation of peptidyl-threonine phosphorylation involved_in IDA
GO:0050731 Biological Process positive regulation of peptidyl-tyrosine phosphorylation involved_in IDA
GO:1902523 Biological Process positive regulation of protein K63-linked ubiquitination involved_in IDA
GO:0032092 Biological Process positive regulation of protein binding involved_in IMP
GO:0031398 Biological Process positive regulation of protein ubiquitination involved_in IMP
GO:0031398 Biological Process positive regulation of protein ubiquitination involved_in NAS
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in NAS
GO:0032760 Biological Process positive regulation of tumor necrosis factor production involved_in IEA
GO:0032729 Biological Process positive regulation of type II interferon production involved_in IEA
GO:1904417 Biological Process positive regulation of xenophagy involved_in IEA
GO:0051260 Biological Process protein homooligomerization involved_in IDA
GO:0043330 Biological Process response to exogenous dsRNA involved_in IEA
GO:0070555 Biological Process response to interleukin-1 involved_in IEA
GO:0070671 Biological Process response to interleukin-12 involved_in IEA
GO:0070673 Biological Process response to interleukin-18 involved_in IEA
GO:0007165 Biological Process signal transduction involved_in TAS
GO:0034134 Biological Process toll-like receptor 2 signaling pathway acts_upstream_of_or_within IDA
GO:0034142 Biological Process toll-like receptor 4 signaling pathway involved_in IEA
GO:0098792 Biological Process xenophagy involved_in IEA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005856 Cellular Component cytoskeleton located_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005783 Cellular Component endoplasmic reticulum located_in IEA
GO:0005886 Cellular Component plasma membrane is_active_in IDA
GO:0032991 Cellular Component protein-containing complex part_of IDA
GO:0032991 Cellular Component protein-containing complex part_of IMP
GO:0031982 Cellular Component vesicle located_in IDA
Pathways
Name DB ID
Cytokine Signaling in Immune system Reactome R-HSA-1280215
Adaptive Immune System Reactome R-HSA-1280218
Signal Transduction Reactome R-HSA-162582
Disease Reactome R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade Reactome R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane Reactome R-HSA-166058
MyD88-independent TLR4 cascade Reactome R-HSA-166166
Toll Like Receptor 9 (TLR9) Cascade Reactome R-HSA-168138
Toll Like Receptor 10 (TLR10) Cascade Reactome R-HSA-168142
Toll Like Receptor 3 (TLR3) Cascade Reactome R-HSA-168164
Toll Like Receptor 5 (TLR5) Cascade Reactome R-HSA-168176
Toll Like Receptor TLR1:TLR2 Cascade Reactome R-HSA-168179
Toll Like Receptor 7/8 (TLR7/8) Cascade Reactome R-HSA-168181
Toll Like Receptor TLR6:TLR2 Cascade Reactome R-HSA-168188
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
NOD1/2 Signaling Pathway Reactome R-HSA-168638
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Reactome R-HSA-168643
Toll-like Receptor Cascades Reactome R-HSA-168898
Toll Like Receptor 2 (TLR2) Cascade Reactome R-HSA-181438
p75NTR signals via NF-kB Reactome R-HSA-193639
p75 NTR receptor-mediated signalling Reactome R-HSA-193704
TCR signaling Reactome R-HSA-202403
Downstream TCR signaling Reactome R-HSA-202424
p75NTR recruits signalling complexes Reactome R-HSA-209543
Metabolism of proteins Reactome R-HSA-392499
TAK1-dependent IKK and NF-kappa-B activation Reactome R-HSA-445989
Interleukin-1 family signaling Reactome R-HSA-446652
Interleukin-17 signaling Reactome R-HSA-448424
Signaling by Interleukins Reactome R-HSA-449147
MAP kinase activation Reactome R-HSA-450294
activated TAK1 mediates p38 MAPK activation Reactome R-HSA-450302
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Reactome R-HSA-450321
Infectious disease Reactome R-HSA-5663205
Deubiquitination Reactome R-HSA-5688426
Ovarian tumor domain proteases Reactome R-HSA-5689896
Post-translational protein modification Reactome R-HSA-597592
Death Receptor Signaling Reactome R-HSA-73887
Interleukin-1 signaling Reactome R-HSA-9020702
TRIF(TICAM1)-mediated TLR4 signaling Reactome R-HSA-937061
SARS-CoV Infections Reactome R-HSA-9679506
SARS-CoV-2 Infection Reactome R-HSA-9694516
SARS-CoV-2 activates/modulates innate and adaptive immune responses Reactome R-HSA-9705671
SARS-CoV-2-host interactions Reactome R-HSA-9705683
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Reactome R-HSA-975138
MyD88 dependent cascade initiated on endosome Reactome R-HSA-975155
MyD88 cascade initiated on plasma membrane Reactome R-HSA-975871
Viral Infection Pathways Reactome R-HSA-9824446
Nucleotide-binding oligomerization domain (NOD) pathway (WP1433) WikiPathways WP1433_r122867
Apoptosis-related network due to altered Notch3 in ovarian cancer (WP2864) WikiPathways WP2864_r108133
T-cell receptor signaling pathway (WP69) WikiPathways WP69_r120966
Fas ligand pathway and stress induction of heat shock proteins (WP314) WikiPathways WP314_r121827
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_003821 6 mRNA transcript variant 1 NC_000008 Reference
NM_001375360 1 mRNA transcript variant 2 NC_000008 Reference
XM_011517357 3 mRNA transcript variant X1 NC_000008 Reference