SEC16B

SEC16 homolog B, endoplasmic reticulum export factor

General Information

Name	SEC16 homolog B, endoplasmic reticulum export factor
Alias	protein transport protein Sec16B leucine zipper transcription regulator 2 protein SEC16 homolog B regucalcin gene promoter region-related protein p117 regucalcin gene promotor region related protein
Gene_family
organism	Homo sapiens
entrez_id	89866
location	1q25.2
transcript_count	5
exon_count	28

Cross References

Location

by NCBI GRCh38.p14

Summary

Entrez SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]

Stringdb Protein transport protein Sec16B; Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization; Belongs to the SEC16 family

nextProt Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:21768384, PubMed:22355596). Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes (PubMed:21768384).

Interactions

NCBI

A	A.Source	B	B.DB	B.Source	Description
SEC16B	BioGRID	HAPSTR1	GeneID	BioGRID	Positive Genetic
SEC16B	BioGRID	RAF1	GeneID	BioGRID	Affinity Capture-MS
SEC16B	BioGRID	POTEF	GeneID	BioGRID	Affinity Capture-MS
SEC16B	BioGRID	SLC25A31	GeneID	BioGRID	Affinity Capture-MS
SEC16B	BioGRID	SEC13	GeneID	BioGRID	Affinity Capture-MS; Two-hybrid
SEC16B	BioGRID	CUL4A	GeneID	BioGRID	Affinity Capture-MS
SEC16B	BioGRID	FBXO7	GeneID	BioGRID	Biochemical Activity
SEC16B	BioGRID	SRPK2	GeneID	BioGRID	Biochemical Activity
SEC16B	None	SEC13	GeneID	HPRD

StringDB

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SEC16B	MON1A	0	0	189	1	1
SEC16B	BSX	0	320	394	1	1
SEC16B	LMAN2L	600	0	613	1	1
SEC16B	MTMR9	0	310	460	1	1
SEC16B	METTL2B	0	180	262	1	1
SEC16B	AGPAT6	0	92	183	1	1
SEC16B	ANKRD40	0	0	771	1	1
SEC16B	HSPA5	0	0	258	1	2
SEC16B	CBLN1	0	92	339	1	1
SEC16B	SH2B1	0	770	771	1	1

Showing 1 to 10 of 551 entries

Ontologies

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GO:0000139	Cellular Component	Golgi membrane	located_in	IEA
GO:0005515	Molecular Function	protein binding	enables	IPI
GO:0005789	Cellular Component	endoplasmic reticulum membrane	located_in	IEA
GO:0005829	Cellular Component	cytosol	located_in	TAS
GO:0006888	Biological Process	endoplasmic reticulum to Golgi vesicle-mediated transport	involved_in	IMP
GO:0006888	Biological Process	endoplasmic reticulum to Golgi vesicle-mediated transport	involved_in	TAS
GO:0006914	Biological Process	autophagy	involved_in	IEA
GO:0007029	Biological Process	endoplasmic reticulum organization	involved_in	IDA
GO:0007030	Biological Process	Golgi organization	involved_in	IBA
GO:0007031	Biological Process	peroxisome organization	involved_in	IDA

Showing 1 to 10 of 20 entries

Pathways

Name	DB	ID
ER to Golgi Anterograde Transport	Reactome	R-HSA-199977
Membrane Trafficking	Reactome	R-HSA-199991
COPII-mediated vesicle transport	Reactome	R-HSA-204005
Metabolism of proteins	Reactome	R-HSA-392499
Asparagine N-linked glycosylation	Reactome	R-HSA-446203
Vesicle-mediated transport	Reactome	R-HSA-5653656
Post-translational protein modification	Reactome	R-HSA-597592
Transport to the Golgi and subsequent modification	Reactome	R-HSA-948021
Regucalcin in proximal tubule epithelial kidney cells (WP4838)	WikiPathways	WP4838_r110282

Transcripts

Accession	Version	MolecularType	Name	NCBI	Comments
NM_001390835	1	mRNA	transcript variant 5	NC_000001	Reference
NM_001390833	1	mRNA	transcript variant 6	NC_000001	Reference
NM_033127	4	mRNA	transcript variant 1	NC_000001	Reference
NM_001390834	1	mRNA	transcript variant 4	NC_000001	Reference
NM_001356499	2	mRNA	transcript variant 2	NC_000001	Reference