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IL33

interleukin 33
General Information
Name interleukin 33
Alias
  • interleukin-33
  • DVS27-related protein
  • interleukin-1 family member 11
  • nuclear factor for high endothelial venules
  • nuclear factor from high endothelial venules
Gene_family Interleukins
organism Homo sapiens
entrez_id 90865
location 9p24.1
transcript_count 15
exon_count 11
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Stringdb Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an \alarmin\", that amplifies immune responses during tissue injury; Interleukins"
    nextProt Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
IL33 BioGRID GALM GeneID BioGRID Affinity Capture-MS
IL33 BioGRID IL1RL1 GeneID BioGRID Reconstituted Complex
IL33 BioGRID USP17L2 GeneID BioGRID Affinity Capture-Western
IL33 BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
IL33 BioGRID USP21 GeneID BioGRID Affinity Capture-Western
IL33 BioGRID CASP1 GeneID BioGRID Biochemical Activity
IL33 BioGRID H2BC21 GeneID BioGRID Reconstituted Complex
IL33 BioGRID H2AC18 GeneID BioGRID Reconstituted Complex
IL33 Protein CRMP1 GeneID HPRD
IL33 Protein IL1RL1 GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
IL33 DPP4 0 0 140 169 1 1
IL33 CXCR6 0 0 310 309 1 1
IL33 GFAP 0 0 167 186 1 2
IL33 CCL20 0 0 564 564 1 1
IL33 GATA1 0 0 246 245 1 1
IL33 IL10 0 0 720 723 1 2
IL33 MAF 0 0 273 273 1 1
IL33 FLT3 0 0 235 235 1 2
IL33 NFIL3 0 0 324 323 1 1
IL33 IRAK4 0 600 482 784 1 1
IL33 COL1A1 0 0 251 250 1 2
IL33 CXCL2 0 0 518 536 1 1
IL33 TJP1 0 0 249 265 1 1
IL33 SRGN 0 0 150 181 1 1
IL33 MAVS 0 0 160 159 1 2
IL33 SELE 0 0 270 313 1 1
IL33 TGFBR2 0 0 212 230 1 1
IL33 CRYGC 0 0 294 294 1 1
IL33 TAC1 0 0 685 692 1 1
IL33 GBP1 0 0 0 150 1 1
IL33 CCL4 0 0 466 472 1 1
IL33 IL1A 0 0 710 710 1 1
IL33 GDF15 0 0 294 294 1 1
IL33 ACTG1 0 0 169 170 1 1
IL33 ABCA1 0 0 161 179 1 2
IL33 CCL23 0 0 181 191 1 1
IL33 PLA2G10 0 0 161 161 1 1
IL33 CCR10 0 0 205 205 1 1
IL33 AGER 0 0 341 341 1 2
IL33 ICAM3 0 0 195 195 1 1
IL33 CCL3 0 0 524 537 1 1
IL33 CTSG 0 0 460 459 1 1
IL33 ENG 0 0 143 168 1 2
IL33 CCL22 0 0 518 518 1 1
IL33 FCGR3B 0 0 390 390 1 1
IL33 C4B 0 0 167 214 1 1
IL33 PDE4D 0 0 265 265 1 1
IL33 AIM2 0 0 391 390 1 2
IL33 DDX58 0 0 382 382 1 1
IL33 PDGFRA 0 0 167 216 1 1
IL33 IGF2 0 0 134 164 1 1
IL33 NMU 0 0 229 228 1 1
IL33 MARCO 0 0 145 200 1 1
IL33 PLG 0 0 194 194 1 1
IL33 IL23A 0 0 325 325 1 1
IL33 THBD 0 0 181 204 1 1
IL33 IL18RAP 0 0 408 425 1 1
IL33 CD33 0 0 158 168 1 1
IL33 BMP7 0 0 113 153 1 1
IL33 MB21D1 0 0 163 163 1 1
IL33 CDH1 0 0 340 340 1 2
IL33 DEFB4B 0 0 218 218 1 1
IL33 TMEM201 0 0 292 292 1 1
IL33 PDPN 0 0 252 268 1 1
IL33 CLEC4E 0 0 235 235 1 1
IL33 RORC 0 0 413 433 1 1
IL33 ARTN 0 0 159 158 1 1
IL33 SIRPA 0 0 193 217 1 1
IL33 IL21R 0 0 181 181 1 1
IL33 TNFRSF9 0 0 212 212 1 1
IL33 MGEA5 0 0 273 273 1 1
IL33 CD226 0 0 167 167 1 1
IL33 MAPK14 0 0 211 295 1 2
IL33 PDGFRB 0 0 123 165 1 2
IL33 IL9 0 0 739 739 1 1
IL33 FCGR2A 0 0 391 404 1 1
IL33 IL27 0 0 201 202 1 1
IL33 UCP1 0 0 323 323 1 2
IL33 IL4 0 0 816 835 1 1
IL33 IPO5 0 0 460 460 1 1
IL33 IL17F 0 0 600 600 1 1
IL33 SPARC 0 0 107 164 1 2
IL33 SMAD3 0 0 400 400 1 2
IL33 SYK 0 0 325 325 1 2
IL33 LEP 0 0 323 323 1 1
IL33 SERPINB1 0 0 66 344 1 1
IL33 S1PR1 0 0 292 323 1 1
IL33 NFKBIA 0 0 335 335 1 2
IL33 KIT 0 0 517 531 1 2
IL33 CTBS 0 0 0 167 1 1
IL33 PLA2G5 0 0 157 179 1 1
IL33 CASP5 0 0 282 301 1 1
IL33 CD276 0 0 375 375 1 1
IL33 IDO1 0 0 242 241 1 1
IL33 FCER1G 0 0 119 198 1 1
IL33 IL16 0 0 452 452 1 1
IL33 MRGPRX2 0 0 335 335 1 1
IL33 ALB 0 0 394 448 1 2
IL33 CASP8 0 0 283 283 1 2
IL33 CD68 0 0 339 339 1 2
IL33 DCLK1 0 0 125 179 1 1
IL33 CD200 0 0 164 163 1 1
IL33 PDCD1LG2 0 0 321 335 1 1
IL33 LTB4R2 0 0 151 150 1 1
IL33 CCL2 0 0 650 675 1 2
IL33 NFATC1 0 0 256 256 1 2
IL33 FPR1 0 0 195 195 1 1
IL33 IRF4 0 0 457 457 1 1
IL33 NLRP6 0 0 325 325 1 1
IL33 VEGFA 0 0 499 508 1 2
IL33 ITGB1 0 0 137 169 1 1
IL33 SIGLEC8 0 0 492 498 1 1
IL33 TYROBP 0 0 155 188 1 1
IL33 MBP 0 0 150 187 1 2
IL33 CASP7 0 0 267 267 1 1
IL33 IL17RE 0 0 123 361 1 1
IL33 LIF 0 0 184 183 1 2
IL33 STAT2 0 0 162 205 1 1
IL33 CXCR3 0 0 414 414 1 1
IL33 HSPA4 0 0 193 193 1 1
IL33 SLC22A5 0 0 155 154 1 1
IL33 ELN 0 0 170 200 1 1
IL33 CX3CR1 0 0 369 369 1 1
IL33 CRHR1 0 0 151 169 1 1
IL33 C1QA 0 0 90 182 1 1
IL33 IL12RB2 0 0 203 203 1 1
IL33 IRF1 0 0 267 267 1 2
IL33 ITGA1 0 0 264 278 1 1
IL33 NDUFAB1 0 0 162 184 1 1
IL33 HIST3H2A 0 0 0 213 1 1
IL33 CCR2 0 0 460 459 1 2
IL33 HYDIN 0 0 54 151 1 1
IL33 DEFB103B 0 0 210 210 1 1
IL33 PPARA 0 0 181 181 1 2
IL33 TLR8 0 0 325 339 1 1
IL33 CRH 0 0 194 194 1 1
IL33 LGR5 0 0 163 163 1 1
IL33 TEK 0 0 125 177 1 1
IL33 CXCL9 0 0 469 485 1 1
IL33 DSG1 0 0 180 179 1 1
IL33 PYHIN1 0 0 358 358 1 1
IL33 IL18BP 0 0 459 459 1 1
IL33 PCDH1 0 0 170 211 1 1
IL33 ACKR2 0 0 372 385 1 1
IL33 TRAF6 0 600 459 774 1 2
IL33 PDCD1 0 0 228 239 1 2
IL33 GATA2 0 0 211 211 1 1
IL33 ITGAM 0 0 602 605 1 1
IL33 TRPA1 0 0 194 194 1 1
IL33 P2RY2 0 0 294 294 1 1
IL33 LYN 0 0 204 204 1 1
IL33 CTSK 0 0 185 205 1 2
IL33 CYCS 0 0 161 161 1 2
IL33 NRP1 0 0 142 166 1 1
IL33 TLR7 0 0 459 470 1 2
IL33 ESR1 0 0 166 165 1 2
IL33 WDR36 0 0 401 400 1 1
IL33 IFNB1 0 0 460 459 1 1
IL33 IL13RA2 0 0 310 334 1 1
IL33 CXCL11 0 0 391 390 1 1
IL33 HMGB1 0 0 560 560 1 2
IL33 DUOX2 0 0 181 181 1 1
IL33 IRF5 0 0 201 201 1 1
IL33 SPI1 0 0 321 321 1 1
IL33 CTSB 0 0 253 252 1 2
IL33 FAM110B 0 0 0 187 1 1
IL33 IL17A 0 0 759 759 1 2
IL33 CTF1 0 0 174 173 1 1
IL33 CST7 0 0 148 342 1 1
IL33 EGF 0 0 370 370 1 2
IL33 PRTN3 0 0 336 336 1 1
IL33 SIRT1 0 0 151 150 1 2
IL33 IL10RB 0 0 246 245 1 1
IL33 OVOL1 0 0 139 169 1 1
IL33 PCSK1 0 0 194 208 1 1
IL33 EOMES 0 0 378 378 1 1
IL33 CXCL17 0 0 139 166 1 1
IL33 ETS1 0 0 174 173 1 1
IL33 NLRP5 0 0 161 161 1 1
IL33 C1QC 0 0 60 177 1 1
IL33 TBP 0 0 219 219 1 1
IL33 FN1 0 0 398 440 1 2
IL33 KLRD1 0 0 229 228 1 1
IL33 ADIPOQ 0 0 283 282 1 2
IL33 HIST1H2AI 270 0 0 270 1 1
IL33 SSTR1 0 0 0 235 1 1
IL33 CCR7 0 0 392 392 1 1
IL33 IKBKG 0 0 212 212 1 1
IL33 RAG2 0 0 392 392 1 1
IL33 HIST1H2AA 0 0 167 167 1 1
IL33 CPA3 0 0 370 390 1 1
IL33 CCR9 0 0 294 294 1 1
IL33 TFF2 0 0 334 334 1 1
IL33 MMP13 0 0 245 244 1 2
IL33 ARG1 0 0 544 544 1 2
IL33 IL5RA 0 0 422 422 1 1
IL33 TPD52L3 0 0 234 234 1 1
IL33 CXCR5 0 0 294 338 1 1
IL33 MAPK8 0 0 243 242 1 2
IL33 C3 0 0 213 258 1 2
IL33 ELANE 0 0 401 402 1 1
IL33 CALCA 0 0 202 202 1 1
IL33 NMUR1 0 0 358 359 1 1
IL33 TMEM261 0 0 193 193 1 1
IL33 TBX21 0 0 609 609 1 1
IL33 NCAM1 0 0 290 290 1 1
IL33 VR1 0 0 208 208 1 1
IL33 ZNF234 0 0 180 179 1 1
IL33 SERPINB5 0 0 0 510 1 1
IL33 CD1E 0 0 230 230 1 1
IL33 GSDMB 0 0 603 603 1 1
IL33 BATF3 0 0 167 167 1 1
IL33 XCL1 0 0 176 175 1 1
IL33 TMEM79 0 0 180 180 1 1
IL33 IL1F10 0 0 667 667 1 1
IL33 SERPINB9 0 0 45 239 1 1
IL33 SERPINB8 0 0 0 521 1 1
IL33 IFIH1 0 0 292 292 1 1
IL33 LOR 0 0 260 276 1 1
IL33 HAND2 0 0 57 539 1 1
IL33 HIST2H3PS2 0 0 151 150 1 1
IL33 ADAM17 0 0 241 240 1 1
IL33 P2RX7 0 0 335 370 1 2
IL33 IL22RA1 0 0 298 298 1 1
IL33 BPIFA1 0 0 168 167 1 1
IL33 CTGF 0 0 279 301 1 1
IL33 FLG 0 0 556 556 1 1
IL33 CMA1 0 0 507 514 1 1
IL33 IL2RG 0 0 283 312 1 1
IL33 PRF1 0 0 392 392 1 1
IL33 NR3C1 0 0 228 227 1 1
IL33 CISH 0 0 212 212 1 1
IL33 PTGER4 0 0 277 277 1 1
IL33 ENSG00000255819 0 0 294 294 1 1
IL33 CCR1 0 0 296 300 1 1
IL33 H2AFZ 0 0 302 492 1 1
IL33 EPX 0 0 451 451 1 1
IL33 OBBP2 0 0 97 329 1 1
IL33 FASLG 0 0 261 261 1 1
IL33 FOS 0 0 245 244 1 2
IL33 AZGP1 0 0 0 158 1 1
IL33 CCL27 0 0 687 692 1 1
IL33 S100A8 0 0 181 181 1 2
IL33 CYSLTR1 0 0 469 469 1 1
IL33 FYN 0 0 127 154 1 1
IL33 JAG1 0 0 211 211 1 1
IL33 IL31 0 0 704 704 1 1
IL33 LCK 0 0 167 167 1 1
IL33 CCRL2 0 0 455 455 1 1
IL33 SOCS3 0 0 322 321 1 1
IL33 IL17RA 0 0 454 454 1 1
IL33 CLEC6A 0 0 285 284 1 1
IL33 SSTR5 0 0 0 303 1 1
IL33 CLEC9A 0 0 204 223 1 1
IL33 IL36RN 0 0 611 611 1 1
IL33 P2RY12 0 0 170 208 1 1
IL33 IL7R 0 0 670 670 1 1
IL33 IL37 0 0 690 690 1 1
IL33 CCR5 0 0 340 340 1 1
IL33 CD69 0 0 424 424 1 1
IL33 AQP4 0 0 134 189 1 1
IL33 STAT5A 0 0 458 457 1 1
IL33 LTA 0 0 372 415 1 1
IL33 CLDN2 0 0 218 235 1 1
IL33 SIGIRR 0 0 737 743 1 1
IL33 IRAK3 0 0 309 309 1 1
IL33 TNIP1 0 0 134 161 1 1
IL33 FCER1A 0 0 459 460 1 1
IL33 DLL1 0 0 187 187 1 1
IL33 LRRC32 0 0 323 363 1 1
IL33 CASP14 0 0 122 154 1 1
IL33 LTC4S 0 0 321 333 1 1
IL33 HAVCR2 0 0 235 235 1 1
IL33 CCL8 0 0 335 358 1 1
IL33 CD8A 0 0 634 634 1 1
IL33 MYO3B 0 0 0 189 1 1
IL33 COL3A1 0 0 182 222 1 1
IL33 TNFSF4 0 0 655 655 1 1
IL33 ITGB2 0 0 142 232 1 1
IL33 HIST1H2BC 270 0 0 270 1 1
IL33 KRAS 0 0 135 167 1 2
IL33 IL1RAPL2 0 0 340 345 1 1
IL33 RIPK2 0 0 217 217 1 2
IL33 UHRF2 0 0 210 259 1 1
IL33 TCF7 0 0 160 177 1 1
IL33 ADRBK1 0 0 182 181 1 1
IL33 RUNX3 0 0 212 212 1 1
IL33 IRF6 0 0 290 290 1 1
IL33 MMP2 0 0 265 282 1 2
IL33 RNASE3 0 0 456 456 1 1
IL33 CD3E 0 0 193 243 1 1
IL33 SSTR3 0 0 0 303 1 1
IL33 TREM2 0 0 218 246 1 1
IL33 IFNGR1 0 0 181 192 1 1
IL33 CCL17 0 0 616 616 1 1
IL33 PTGES 0 0 151 150 1 1
IL33 FBXL19 0 0 426 426 1 1
IL33 THBS1 0 0 181 182 1 1
IL33 CD27 0 0 264 264 1 1
IL33 SDC1 0 0 155 154 1 1
IL33 CCL7 0 0 458 483 1 1
IL33 CXCL6 0 0 261 293 1 1
IL33 CASP1 488 800 682 968 1 2
IL33 CCR3 0 0 466 475 1 1
IL33 TLR6 0 0 324 393 1 1
IL33 IL2 0 0 849 849 1 1
IL33 ITGA2 0 0 261 296 1 1
IL33 ANXA1 0 0 151 150 1 1
IL33 HLA-DRB1 0 0 156 155 1 1
IL33 TLR2 0 0 595 603 1 2
IL33 TNFSF10 0 0 236 253 1 2
IL33 DUSP1 0 0 167 167 1 1
IL33 ORMDL3 0 0 601 601 1 2
IL33 AIF1 0 0 193 193 1 2
IL33 FFAR2 0 0 201 201 1 1
IL33 PTGER3 0 0 139 167 1 1
IL33 TOLLIP 0 0 155 154 1 1
IL33 HSH2D 0 0 150 169 1 1
IL33 ZBTB16 0 0 294 294 1 1
IL33 JAK3 0 0 230 229 1 1
IL33 SERPINB2 0 0 134 562 1 1
IL33 CD86 0 0 470 470 1 1
IL33 GZMA 0 0 194 200 1 1
IL33 IL10RA 0 0 318 317 1 1
IL33 TACR1 0 0 193 213 1 1
IL33 IL18R1 0 0 807 807 1 1
IL33 NPPB 0 0 233 232 1 1
IL33 CCL24 0 0 602 602 1 1
IL33 BGN 0 0 142 192 1 1
IL33 IGIP 0 0 46 222 1 1
IL33 SERPINA1 0 0 202 202 1 2
IL33 ENSG00000277117 0 0 391 409 1 1
IL33 ENSG00000173366 0 0 503 510 1 1
IL33 COL16A1 0 0 49 152 1 1
IL33 BATF 0 0 284 284 1 1
IL33 CD72 0 0 414 414 1 1
IL33 MADCAM1 0 0 218 218 1 1
IL33 JUN 0 0 358 359 1 2
IL33 TYK2 0 0 181 181 1 1
IL33 NOD1 0 0 403 403 1 2
IL33 FUT2 0 0 143 162 1 1
IL33 CXCL1 0 0 563 579 1 2
IL33 DEXI 0 0 181 181 1 1
IL33 HIST2H2AA3 0 0 156 194 1 1
IL33 CLEC14A 0 0 0 173 1 1
IL33 MBL2 0 0 156 155 1 1
IL33 HPGDS 0 0 193 232 1 1
IL33 IL21 0 0 122 510 1 1
IL33 NLRP3 0 0 630 638 1 2
IL33 HSP90AA1 0 0 144 154 1 2
IL33 PTGDR 0 0 194 208 1 1
IL33 REL 0 0 167 167 1 2
IL33 IL3 0 0 680 712 1 1
IL33 LTB 0 0 167 167 1 1
IL33 SSTR2 0 0 0 642 1 1
IL33 CRP 0 0 458 457 1 2
IL33 CLEC16A 0 0 183 183 1 2
IL33 IL1RL1 932 800 989 999 1 1
IL33 PTGS2 0 0 382 383 1 2
IL33 CCL11 0 0 659 672 1 1
IL33 CEBPA 0 0 159 158 1 1
IL33 PTGDR2 0 0 667 669 1 1
IL33 CASP3 0 0 377 377 1 2
IL33 F3 0 0 186 219 1 1
IL33 FGF1 0 0 142 201 1 1
IL33 CD40 0 0 460 459 1 2
IL33 NLRX1 0 0 207 207 1 2
IL33 CTSS 0 0 324 338 1 1
IL33 ACE 0 0 165 183 1 1
IL33 KLK5 0 0 170 169 1 1
IL33 C1S 0 0 122 174 1 1
IL33 HIST2H2AA 270 0 156 387 1 1
IL33 FPR2 0 0 219 219 1 1
IL33 ALOX5 0 0 324 323 1 1
IL33 EPRS 0 0 270 270 1 1
IL33 SELL 0 0 391 390 1 1
IL33 TNFSF13B 0 0 390 403 1 1
IL33 TMED1 0 0 218 218 1 1
IL33 REN 0 0 150 173 1 1
IL33 IL17B 0 0 521 521 1 1
IL33 EMR2 0 0 94 181 1 1
IL33 USP17L2 270 0 120 330 1 1
IL33 CLDN5 0 0 94 159 1 1
IL33 RNASE2 0 0 409 408 1 1
IL33 CCL15 0 0 301 309 1 1
IL33 SELP 0 0 254 293 1 1
IL33 CD1B 0 0 234 234 1 1
IL33 INS 0 0 358 358 1 2
IL33 IL13 0 0 862 864 1 2
IL33 ACTB 0 0 414 424 1 2
IL33 VEGFC 0 0 184 183 1 1
IL33 FCGR2B 0 0 459 459 1 1
IL33 CD28 0 0 426 426 1 1
IL33 CD5 0 0 321 322 1 1
IL33 CYBB 0 0 217 234 1 2
IL33 THY1 0 0 451 484 1 1
IL33 ANGPT1 0 0 146 172 1 1
IL33 CXCL5 0 0 454 478 1 1
IL33 MMP9 0 0 454 454 1 2
IL33 B2M 0 0 170 169 1 1
IL33 MAPK3 0 0 330 330 1 2
IL33 FGL2 0 0 194 271 1 1
IL33 IFNAR2 0 0 165 165 1 1
IL33 EPCAM 0 0 266 275 1 2
IL33 CASP4 0 0 159 181 1 2
IL33 CXCL16 0 0 287 286 1 1
IL33 ACTL9 0 0 142 164 1 1
IL33 ADM 0 0 157 156 1 2
IL33 FABP4 0 0 138 182 1 1
IL33 CD1C 0 0 264 264 1 1
IL33 GUSB 0 0 123 158 1 1
IL33 NMUR2 0 0 150 172 1 1
IL33 MRC1 0 0 459 478 1 1
IL33 CSF2RA 0 0 155 154 1 1
IL33 ITGAX 0 0 601 605 1 1
IL33 SPP1 0 0 325 325 1 2
IL33 ZPBP2 0 0 390 390 1 1
IL33 CXCL12 0 0 423 444 1 2
IL33 CCL18 0 0 341 369 1 1
IL33 GPR29 0 0 458 465 1 1
IL33 IL1RAP 0 600 989 998 1 1
IL33 KLK11 0 0 381 397 1 1
IL33 PI16 0 0 123 155 1 1
IL33 IL36A 0 0 460 471 1 1
IL33 TIMP1 0 0 324 338 1 1
IL33 KLF2 0 0 193 193 1 1
IL33 KLRK1 0 0 294 294 1 1
IL33 PIGR 0 0 123 152 1 1
IL33 TNNI3 0 0 195 195 1 1
IL33 PLA2G1B 0 0 193 193 1 1
IL33 CHUK 0 0 203 203 1 1
IL33 S100A12 0 0 211 211 1 1
IL33 CRLF2 0 0 612 613 1 1
IL33 TLR5 0 0 419 418 1 1
IL33 CD248 0 0 100 150 1 1
IL33 NLRP9 0 0 136 154 1 1
IL33 CXCR1 0 0 255 256 1 1
IL33 CIITA 0 0 194 223 1 1
IL33 PTPRC 0 0 560 572 1 1
IL33 NOD2 0 0 455 455 1 2
IL33 CEBPB 0 0 170 169 1 2
IL33 MLKL 0 0 310 309 1 2
IL33 H2AFB1 0 0 457 457 1 1
IL33 ATG16L1 0 0 172 171 1 2
IL33 TRPM5 0 0 181 181 1 1
IL33 IL13RA1 0 0 279 312 1 1
IL33 LTBR 0 0 167 167 1 1
IL33 ICAM1 0 0 467 467 1 2
IL33 HDAC1 0 0 153 176 1 2
IL33 CD24 0 0 162 205 1 2
IL33 PRDM1 0 0 385 385 1 1
IL33 ZNF683 0 0 207 207 1 1
IL33 TAS2R38 0 0 161 161 1 1
IL33 RIPK1 0 0 292 292 1 2
IL33 IL22 0 0 564 564 1 1
IL33 CSF1 0 0 414 426 1 1
IL33 APLNR 0 0 48 175 1 1
IL33 SERPINB3 0 0 75 326 1 1
IL33 MPO 0 0 402 402 1 2
IL33 IL3RA 0 0 298 298 1 1
IL33 TNFSF12 0 0 123 154 1 1
IL33 STAT6 0 0 611 611 1 1
IL33 FMO2 0 0 54 165 1 1
IL33 FAM110A 0 0 0 371 1 1
IL33 IL6 0 0 739 739 1 2
IL33 A2M 0 0 119 184 1 1
IL33 TMEM232 0 0 172 171 1 1
IL33 CCR8 0 0 328 328 1 1
IL33 EIF2AK3 0 0 135 154 1 2
IL33 LYVE1 0 0 167 298 1 1
IL33 CXCL14 0 0 217 261 1 1
IL33 SERPINB7 0 0 0 521 1 1
IL33 MOG 0 0 193 210 1 1
IL33 GPR37 0 0 0 288 1 1
IL33 TNFRSF18 0 0 278 278 1 1
IL33 FLT1 0 0 122 177 1 1
IL33 CD180 0 0 350 349 1 1
IL33 STAT1 0 0 450 451 1 2
IL33 IL17D 0 0 167 167 1 1
IL33 HRH1 0 0 232 248 1 1
IL33 OCLN 0 0 310 315 1 1
IL33 LGALS3 0 0 390 390 1 2
IL33 MIF 0 0 232 231 1 2
IL33 TLR3 0 0 508 518 1 2
IL33 GZMB 0 0 390 390 1 1
IL33 TNFRSF1A 0 0 370 370 1 1
IL33 IL19 0 0 383 382 1 1
IL33 HLA-G 0 0 170 169 1 1
IL33 FGF13 0 0 252 252 1 1
IL33 CDSN 0 0 181 181 1 1
IL33 CXCR4 0 0 325 325 1 2
IL33 USP21 270 600 171 736 1 1
IL33 RAG1 0 0 338 338 1 1
IL33 IRF8 0 0 241 257 1 1
IL33 HP 0 0 201 201 1 1
IL33 CD40LG 0 0 415 414 1 1
IL33 PTGS1 0 0 162 161 1 1
IL33 MMP1 0 0 218 218 1 1
IL33 SRC 0 0 217 234 1 2
IL33 NOTCH1 0 0 300 300 1 2
IL33 ENTPD1 0 0 321 321 1 1
IL33 IL26 0 0 282 282 1 1
IL33 IL36B 0 0 454 465 1 1
IL33 APOE 0 0 294 309 1 2
IL33 NLRP1 0 0 460 459 1 1
IL33 MTOR 0 0 202 202 1 2
IL33 SPINK5 0 0 338 338 1 1
IL33 SAA1 0 0 250 250 1 1
IL33 CD163 0 0 335 359 1 1
IL33 XPNPEP1 0 0 263 264 1 1
IL33 C4A 0 0 158 206 1 1
IL33 TNFSF11 0 0 391 390 1 2
IL33 IL25 0 0 601 601 1 1
IL33 PRG2 0 0 204 204 1 1
IL33 TIMP4 0 0 82 195 1 1
IL33 POTEF 0 0 167 182 1 1
IL33 H2AFV 0 0 0 187 1 1
IL33 CTNNB1 0 0 218 218 1 2
IL33 HRAS 0 0 150 172 1 2
IL33 FCGR3A 0 0 391 413 1 1
IL33 TXLNA 0 0 186 186 1 1
IL33 RIPK3 0 0 282 282 1 2
IL33 CRMP1 0 0 457 457 1 1
IL33 IFIT1 0 0 142 157 1 1
IL33 MMP10 0 0 150 184 1 1
IL33 REG3A 0 0 233 232 1 1
IL33 TRPV1 0 0 208 208 1 2
IL33 APP 0 0 161 188 1 2
IL33 HRH4 0 0 252 252 1 1
IL33 C3AR1 0 0 146 173 1 1
IL33 TGFB1 0 0 283 381 1 2
IL33 STAT5B 0 0 456 456 1 1
IL33 CXCR2 0 0 459 459 1 1
IL33 GHITM 0 0 425 424 1 1
IL33 SCGB1A1 0 0 253 266 1 1
IL33 B7RP1 0 0 391 409 1 1
IL33 PF4 0 0 163 163 1 1
IL33 TNFRSF1B 0 0 164 163 1 1
IL33 VIPR2 0 0 155 154 1 1
IL33 C1QB 0 0 90 182 1 1
IL33 ADORA2B 0 0 162 161 1 1
IL33 POSTN 0 0 470 495 1 1
IL33 EDN1 0 0 282 282 1 1
IL33 HIF1A 0 0 289 288 1 2
IL33 KDR 0 0 158 203 1 2
IL33 JAK1 0 0 288 288 1 2
IL33 ICOS 0 0 359 408 1 1
IL33 MMP12 0 0 310 309 1 1
IL33 TPSAB1 0 0 156 231 1 1
IL33 IL1B 0 0 770 770 1 2
IL33 KLRB1 0 0 405 405 1 1
IL33 CDHR3 0 0 501 511 1 1
IL33 NFATC2 0 0 155 154 1 1
IL33 CXCL8 0 0 681 687 1 2
IL33 NCR3 0 0 181 181 1 1
IL33 ENSG00000268500 0 0 97 329 1 1
IL33 TBK1 0 0 181 181 1 2
IL33 PPBP 0 0 216 216 1 1
IL33 NCR2 0 0 371 371 1 1
IL33 FOXP3 0 0 620 627 1 2
IL33 HMOX1 0 0 247 246 1 2
IL33 IL32 0 0 405 405 1 1
IL33 IL6R 0 0 326 325 1 1
IL33 NCR1 0 0 465 466 1 1
IL33 IL9R 0 0 392 392 1 1
IL33 EMR1 0 0 60 310 1 1
IL33 SMAD2 0 0 218 218 1 2
IL33 TLR4 0 0 635 655 1 2
IL33 SERPINB6 0 0 0 270 1 1
IL33 GAPDH 0 0 456 456 1 2
IL33 FMOD 0 0 74 166 1 1
IL33 NOX4 0 0 134 165 1 2
IL33 METRNL 0 0 167 219 1 1
IL33 DUSP5 0 0 171 171 1 1
IL33 CFH 0 0 125 214 1 1
IL33 TNFRSF25 0 0 267 267 1 1
IL33 CYSLTR2 0 0 305 305 1 1
IL33 PANX1 0 0 244 243 1 1
IL33 TNFSF15 0 0 466 476 1 1
IL33 DUOX1 0 0 294 294 1 1
IL33 KLF4 0 0 163 163 1 2
IL33 CD83 0 0 185 185 1 1
IL33 CD14 0 0 0 169 1 1
IL33 CLDN1 0 0 126 167 1 1
IL33 COL1A2 0 0 150 181 1 1
IL33 EPGN 0 0 122 161 1 1
IL33 IKBKB 0 0 282 282 1 2
IL33 NLRC4 0 0 458 457 1 2
IL33 CPA4 0 0 342 342 1 1
IL33 NOS2 0 0 305 310 1 2
IL33 CD1A 0 0 230 229 1 1
IL33 CX3CL1 0 0 341 360 1 1
IL33 ATP7A 0 0 260 260 1 1
IL33 CD247 0 0 134 158 1 1
IL33 SPDEF 0 0 276 276 1 1
IL33 VIP 0 0 213 257 1 1
IL33 VCAM1 0 0 407 439 1 1
IL33 CCL14 0 0 181 246 1 1
IL33 CD4 0 0 713 737 1 2
IL33 KITLG 0 0 422 449 1 1
IL33 ITGA4 0 0 180 179 1 1
IL33 STAT4 0 0 293 346 1 1
IL33 FAS 0 0 125 164 1 2
IL33 ACKR4 0 0 243 261 1 1
IL33 TLR10 0 0 240 334 1 1
IL33 CLEC7A 0 0 395 394 1 1
IL33 CARD8 0 0 165 165 1 1
IL33 ACKR1 0 0 123 198 1 1
IL33 IL17C 0 0 353 353 1 1
IL33 MKI67 0 0 46 158 1 2
IL33 OXGR1 0 0 210 231 1 1
IL33 IL12RB1 0 0 306 306 1 1
IL33 CSF2 0 0 681 681 1 1
IL33 LY96 0 0 324 323 1 1
IL33 NFKB1 0 0 181 181 1 2
IL33 ACKR3 0 0 134 157 1 1
IL33 RORA 0 0 426 426 1 1
IL33 AOC3 0 0 370 392 1 1
IL33 CCL4L1 0 0 336 344 1 1
IL33 EMCN 0 0 57 178 1 1
IL33 IL17RB 0 0 661 667 1 1
IL33 PPARG 0 0 390 390 1 2
IL33 AKT1 0 0 488 488 1 2
IL33 RELA 0 0 218 296 1 2
IL33 BCL2L1 0 0 211 215 1 2
IL33 TGFB2 0 0 245 263 1 1
IL33 OSMR 0 0 161 181 1 1
IL33 FGF21 0 0 164 177 1 2
IL33 TNFSF13 0 0 125 165 1 1
IL33 DMRT3 0 0 0 188 1 1
IL33 ANXA5 0 0 261 277 1 2
IL33 NLRP7 0 0 218 264 1 1
IL33 IRF3 0 0 329 329 1 2
IL33 LGALS9 0 0 169 169 1 1
IL33 NGF 0 0 291 290 1 2
IL33 CD34 0 0 422 451 1 2
IL33 ARG2 0 0 326 325 1 1
IL33 IL4R 0 0 509 515 1 1
IL33 GSDMA 0 0 336 336 1 1
IL33 TLR9 0 0 505 512 1 2
IL33 CXCL13 0 0 391 404 1 1
IL33 PYCARD 0 0 420 420 1 2
IL33 C5AR1 0 0 252 268 1 1
IL33 DPH6 0 0 71 214 1 1
IL33 IL6ST 0 0 143 162 1 1
IL33 METRN 0 0 218 242 1 1
IL33 LTB4R 0 0 218 218 1 1
IL33 TNFSF8 0 0 194 194 1 1
IL33 IL1RAPL1 0 0 194 200 1 1
IL33 TNFSF18 0 0 241 240 1 1
IL33 CLCA1 0 0 370 370 1 1
IL33 CD1D 0 0 403 403 1 1
IL33 BCL11B 0 0 260 260 1 1
IL33 CXCL10 0 0 560 560 1 2
IL33 CCL13 0 0 342 359 1 1
IL33 HRH2 0 0 158 157 1 1
IL33 HIST2H2AC 0 0 961 961 1 1
IL33 GJA1 0 0 161 206 1 1
IL33 BCL6 0 0 218 237 1 1
IL33 IFNG 0 0 469 613 1 2
IL33 NOX3 0 0 330 344 1 1
IL33 IL2RB 0 0 391 390 1 1
IL33 IL24 0 0 335 335 1 2
IL33 GSDMD 0 0 232 231 1 2
IL33 IL11 0 0 556 556 1 1
IL33 CREB1 0 0 189 189 1 2
IL33 ID2 0 0 425 429 1 1
IL33 CCL5 0 0 598 598 1 2
IL33 GPT 0 0 232 231 1 1
IL33 TGFB3 0 0 183 212 1 1
IL33 SOCS1 0 0 450 450 1 1
IL33 NLRP10 0 0 172 171 1 1
IL33 LILRB1 0 0 166 165 1 1
IL33 VGLL3 0 0 0 189 1 1
IL33 BTK 0 0 155 154 1 1
IL33 MERTK 0 0 187 204 1 1
IL33 TLR1 0 0 395 413 1 1
IL33 CSF1R 0 0 253 283 1 1
IL33 DEFB4A 0 0 270 270 1 1
IL33 TNMD 0 0 71 171 1 1
IL33 IRF7 0 0 290 290 1 1
IL33 IGF1 0 0 288 288 1 2
IL33 USP38 0 0 215 215 1 1
IL33 AREG 0 0 660 666 1 1
IL33 NLRP12 0 0 241 240 1 1
IL33 CCL21 0 0 382 425 1 1
IL33 CDH5 0 0 134 222 1 1
IL33 CD80 0 0 459 459 1 2
IL33 RETN 0 0 335 335 1 1
IL33 IFNL1 0 0 325 325 1 1
IL33 FFAR3 0 0 170 169 1 1
IL33 CH25H 0 0 146 177 1 1
IL33 F2RL1 0 0 123 259 1 1
IL33 OSM 0 0 296 296 1 1
IL33 DHX58 0 0 170 169 1 1
IL33 IKZF3 0 0 220 220 1 1
IL33 AQP1 0 0 96 200 1 1
IL33 IFNL2 0 0 370 370 1 1
IL33 TXNIP 0 0 161 161 1 2
IL33 SPARCL1 0 0 81 229 1 1
IL33 TNFSF14 0 0 231 232 1 1
IL33 MMP8 0 0 171 171 1 1
IL33 ENGASE 0 0 0 209 1 1
IL33 IFI16 0 0 188 188 1 1
IL33 S100A9 0 0 308 307 1 1
IL33 RELB 0 0 181 181 1 2
IL33 IL31RA 0 0 325 325 1 1
IL33 HTRA3 0 0 60 205 1 1
IL33 FGF2 0 0 324 323 1 2
IL33 CXCL3 0 0 334 359 1 1
IL33 TIGIT 0 0 207 207 1 1
IL33 IL12A 0 0 74 151 1 1
IL33 TNFAIP3 0 0 207 207 1 2
IL33 IL17RC 0 0 242 262 1 1
IL33 NFKB2 0 0 134 157 1 1
IL33 IL34 0 0 392 419 1 1
IL33 ENSG00000272980 0 0 458 465 1 1
IL33 LAG3 0 0 217 217 1 1
IL33 TNFAIP6 0 0 137 158 1 1
IL33 IFNAR1 0 0 225 224 1 1
IL33 IL1RL2 0 0 593 603 1 1
IL33 IL5 0 0 857 867 1 1
IL33 VWF 0 0 167 263 1 1
IL33 CD63 0 0 215 215 1 2
IL33 CHI3L1 0 0 325 359 1 1
IL33 NELFCD 0 0 334 334 1 1
IL33 LY75 0 0 171 171 1 1
IL33 IL1R2 0 0 405 405 1 1
IL33 PIBF1 0 0 157 157 1 1
IL33 MX1 0 0 170 169 1 1
IL33 MEFV 0 0 426 438 1 1
IL33 ADORA1 0 0 159 158 1 1
IL33 C11orf30 0 0 320 319 1 1
IL33 ERMP1 0 0 173 235 1 1
IL33 NTS 0 0 166 184 1 1
IL33 IKZF4 0 0 152 151 1 1
IL33 IL23R 0 0 391 390 1 1
IL33 CD209 0 0 340 340 1 1
IL33 CLEC10A 0 0 135 173 1 1
IL33 IL27RA 0 0 211 211 1 1
IL33 SIGLEC11 0 0 0 187 1 1
IL33 NAIP 0 0 247 246 1 1
IL33 IL2RA 0 0 370 433 1 1
IL33 MMP7 0 0 182 181 1 1
IL33 CD300LF 0 0 157 156 1 1
IL33 IL1RN 0 0 394 394 1 1
IL33 IL15 0 0 595 595 1 1
IL33 S100A7 0 0 263 263 1 1
IL33 MMP3 0 0 322 336 1 1
IL33 MYC 0 0 181 181 1 2
IL33 ITGAE 0 0 507 507 1 1
IL33 HDC 0 0 174 173 1 1
IL33 IL1R1 0 0 837 843 1 1
IL33 MATN2 0 0 120 254 1 1
IL33 CHIA 0 0 357 357 1 1
IL33 CD44 0 0 391 390 1 2
IL33 IFNA1 0 0 469 469 1 1
IL33 IL18 0 0 803 816 1 2
IL33 BDNF 0 0 211 211 1 2
IL33 IL7 0 0 635 640 1 1
IL33 ADAMTS4 0 0 127 158 1 1
IL33 NT5E 0 0 247 246 1 1
IL33 KRT14 0 0 181 181 1 1
IL33 TIRAP 0 0 244 243 1 1
IL33 IL36G 0 0 506 506 1 1
IL33 DPP10 0 0 241 240 1 1
IL33 TREM1 0 0 203 203 1 1
IL33 PPARGC1A 0 0 155 154 1 2
IL33 TNF 0 0 710 729 1 2
IL33 NOV 0 0 703 710 1 1
IL33 PLA2G2A 0 0 180 203 1 1
IL33 PTGDS 0 0 143 213 1 1
IL33 CCL1 0 0 391 390 1 1
IL33 MUC5AC 0 0 504 505 1 1
IL33 CCL25 0 0 208 250 1 1
IL33 ENPP3 0 0 218 218 1 1
IL33 GFI1 0 0 291 290 1 1
IL33 PECAM1 0 0 296 318 1 1
IL33 CAT 0 0 179 196 1 2
IL33 GATA3 0 900 683 967 1 1
IL33 MMP28 0 0 123 155 1 1
IL33 ENSG00000264813 0 0 163 181 1 1
IL33 RETNLB 0 0 459 459 1 1
IL33 FSTL1 0 0 150 167 1 1
IL33 HGF 0 0 181 210 1 2
IL33 SFTPD 0 0 181 201 1 1
IL33 TXN 0 0 137 155 1 1
IL33 HBEGF 0 0 270 270 1 1
IL33 STAT3 0 0 505 505 1 2
IL33 JAK2 0 0 305 305 1 2
IL33 NLRC5 0 0 165 165 1 1
IL33 SCNN1B 0 0 147 165 1 1
IL33 CD38 0 0 160 159 1 2
IL33 HLA-DQB1 0 0 240 239 1 1
IL33 FCER2 0 0 286 286 1 1
IL33 HPRT1 0 0 294 294 1 1
IL33 KLK7 0 0 143 161 1 1
IL33 ZBTB10 0 0 151 157 1 1
IL33 PTX3 0 0 265 265 1 1
IL33 REG3G 0 0 156 155 1 1
IL33 SEMA3D 0 0 49 153 1 1
IL33 CTLA4 0 0 504 504 1 2
IL33 BRD4 0 0 447 447 1 2
IL33 CAPN14 0 0 303 303 1 1
IL33 CCL26 0 0 519 519 1 1
IL33 ANKRD42 0 0 194 194 1 1
IL33 SFTPC 0 0 269 290 1 1
IL33 CCL19 0 0 364 402 1 1
IL33 NR4A1 0 0 161 161 1 2
IL33 TPSD1 0 0 112 174 1 1
IL33 CHIT1 0 0 167 167 1 1
IL33 LPCAT3 0 0 391 474 1 1
IL33 MUC5B 0 0 338 339 1 1
IL33 CLDND1 0 0 112 204 1 1
IL33 ADAMTS1 0 0 96 166 1 1
IL33 ACTA2 0 0 305 325 1 1
IL33 IRAK1 0 600 464 776 1 1
IL33 P2RX4 0 0 193 193 1 1
IL33 CSF3 0 0 460 471 1 1
IL33 NOS3 0 0 184 183 1 2
IL33 FLT3LG 0 0 249 248 1 1
IL33 PDCL 0 0 160 159 1 1
IL33 SSTR4 0 0 0 216 1 1
IL33 CAMP 0 0 325 325 1 2
IL33 CSF2RB 0 0 113 174 1 1
IL33 CD274 0 0 362 362 1 2
IL33 TRAF1 0 0 150 154 1 1
IL33 TIMD4 0 0 155 154 1 1
IL33 FGF7 0 0 170 219 1 1
IL33 CARD9 0 0 218 218 1 1
IL33 TPSB2 0 0 103 165 1 1
IL33 SIGLEC10 0 0 82 221 1 1
IL33 MAP3K7 0 0 160 159 1 2
IL33 CD19 0 0 459 470 1 1
IL33 ADAM33 0 0 392 424 1 1
IL33 NFKBIZ 0 0 156 155 1 1
IL33 TNFRSF11B 0 0 259 273 1 1
IL33 IRAK2 0 0 219 219 1 1
IL33 CD200R1 0 0 210 210 1 1
IL33 DENND1B 0 0 413 425 1 1
IL33 ALOX15 0 0 181 181 1 1
IL33 LOX 0 0 202 202 1 2
IL33 GNLY 0 0 159 158 1 1
IL33 TGM2 0 0 145 167 1 2
IL33 LCN2 0 0 284 284 1 1
IL33 TP53 0 0 232 231 1 2
IL33 IRS1 0 0 134 170 1 2
IL33 DCN 0 0 123 197 1 2
IL33 KLRC1 0 0 204 204 1 1
IL33 IVL 0 0 181 181 1 1
IL33 CD207 0 0 202 202 1 1
IL33 CFTR 0 0 211 211 1 2
IL33 IL20RA 0 0 194 194 1 1
IL33 HMSD 0 0 0 210 1 1
IL33 KLRG1 0 0 564 564 1 1
IL33 PPP1R1C 0 0 51 208 1 1
IL33 LAMP1 0 0 204 204 1 2
IL33 TSLP 0 0 876 881 1 1
IL33 AHR 0 0 408 420 1 2
IL33 SERPINE1 0 0 211 211 1 1
IL33 ZBTB32 0 0 214 296 1 1
IL33 SLPI 0 0 187 187 1 1
IL33 HIST2H2BE 270 0 736 799 1 1
IL33 NLRP2 0 0 167 216 1 1
IL33 FADD 0 0 150 168 1 2
IL33 DEFB103A 0 0 210 210 1 1
IL33 ADRB2 0 0 263 263 1 1
IL33 MYD88 0 600 800 916 1 2
IL33 TNFRSF4 0 0 407 407 1 1
IL33 ADORA3 0 0 156 180 1 1
IL33 FCGR1A 0 0 283 298 1 1
IL33 EGFR 0 0 293 313 1 2
IL33 KANK1 0 0 60 204 1 1
IL33 ECM1 0 0 150 196 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005125 Molecular Function cytokine activity enables IBA
GO:0005125 Molecular Function cytokine activity enables IDA
GO:0002112 Molecular Function interleukin-33 receptor binding enables IEA
GO:0005515 Molecular Function protein binding enables IPI
GO:0071260 Biological Process cellular response to mechanical stimulus involved_in IEA
GO:0051607 Biological Process defense response to virus involved_in IEA
GO:0097191 Biological Process extrinsic apoptotic signaling pathway involved_in IEA
GO:0010467 Biological Process gene expression involved_in IEA
GO:0038172 Biological Process interleukin-33-mediated signaling pathway involved_in ISS
GO:0030225 Biological Process macrophage differentiation involved_in ISS
GO:0002282 Biological Process microglial cell activation involved in immune response involved_in IEA
GO:0061518 Biological Process microglial cell proliferation involved_in IEA
GO:0002826 Biological Process negative regulation of T-helper 1 type immune response involved_in IEA
GO:0002638 Biological Process negative regulation of immunoglobulin production involved_in IEA
GO:0106015 Biological Process negative regulation of inflammatory response to wounding involved_in IDA
GO:0002686 Biological Process negative regulation of leukocyte migration involved_in IEA
GO:0120042 Biological Process negative regulation of macrophage proliferation acts_upstream_of_or_within ISS
GO:0000122 Biological Process negative regulation of transcription by RNA polymerase II involved_in IMP
GO:0032689 Biological Process negative regulation of type II interferon production involved_in IEA
GO:0150145 Biological Process positive regulation of CD80 production acts_upstream_of_or_within ISS
GO:0150142 Biological Process positive regulation of CD86 production acts_upstream_of_or_within ISS
GO:0045345 Biological Process positive regulation of MHC class I biosynthetic process involved_in IEA
GO:0045348 Biological Process positive regulation of MHC class II biosynthetic process involved_in IEA
GO:0010186 Biological Process positive regulation of cellular defense response acts_upstream_of_or_within ISS
GO:0032722 Biological Process positive regulation of chemokine production involved_in IDA
GO:0001819 Biological Process positive regulation of cytokine production involved_in IBA
GO:0010628 Biological Process positive regulation of gene expression acts_upstream_of_or_within ISS
GO:0002639 Biological Process positive regulation of immunoglobulin production involved_in IEA
GO:0050729 Biological Process positive regulation of inflammatory response involved_in IBA
GO:0050729 Biological Process positive regulation of inflammatory response involved_in ISS
GO:0032736 Biological Process positive regulation of interleukin-13 production involved_in IEA
GO:0032753 Biological Process positive regulation of interleukin-4 production involved_in IEA
GO:0032754 Biological Process positive regulation of interleukin-5 production involved_in IEA
GO:0032755 Biological Process positive regulation of interleukin-6 production acts_upstream_of ISS
GO:0032755 Biological Process positive regulation of interleukin-6 production acts_upstream_of_or_within ISS
GO:0043032 Biological Process positive regulation of macrophage activation involved_in IDA
GO:0043032 Biological Process positive regulation of macrophage activation acts_upstream_of_or_within ISS
GO:0150078 Biological Process positive regulation of neuroinflammatory response involved_in TAS
GO:0051770 Biological Process positive regulation of nitric-oxide synthase biosynthetic process acts_upstream_of_or_within ISS
GO:0048714 Biological Process positive regulation of oligodendrocyte differentiation involved_in IEA
GO:0032436 Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved_in IEA
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in ISS
GO:0032760 Biological Process positive regulation of tumor necrosis factor production acts_upstream_of ISS
GO:0032760 Biological Process positive regulation of tumor necrosis factor production acts_upstream_of_or_within ISS
GO:0002830 Biological Process positive regulation of type 2 immune response involved_in IEA
GO:0006606 Biological Process protein import into nucleus involved_in IEA
GO:0042092 Biological Process type 2 immune response involved_in IEA
GO:0005694 Cellular Component chromosome located_in IEA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005576 Cellular Component extracellular region located_in TAS
GO:0005615 Cellular Component extracellular space is_active_in IDA
GO:0043231 Cellular Component intracellular membrane-bounded organelle located_in IDA
GO:0005654 Cellular Component nucleoplasm located_in IDA
GO:0005654 Cellular Component nucleoplasm located_in TAS
GO:0005634 Cellular Component nucleus located_in IDA
GO:0030133 Cellular Component transport vesicle located_in IEA
Pathways
Name DB ID
PIP3 activates AKT signaling Reactome R-HSA-1257604
Cytokine Signaling in Immune system Reactome R-HSA-1280215
Signal Transduction Reactome R-HSA-162582
Immune System Reactome R-HSA-168256
Negative regulation of the PI3K/AKT network Reactome R-HSA-199418
Metabolism of proteins Reactome R-HSA-392499
Interleukin-1 family signaling Reactome R-HSA-446652
Signaling by Interleukins Reactome R-HSA-449147
Deubiquitination Reactome R-HSA-5688426
Ub-specific processing proteases Reactome R-HSA-5689880
Post-translational protein modification Reactome R-HSA-597592
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Reactome R-HSA-6811558
Intracellular signaling by second messengers Reactome R-HSA-9006925
Interleukin-33 signaling Reactome R-HSA-9014843
Network map of SARS-CoV-2 signaling pathway (WP5115) WikiPathways WP5115_r124648
Development and heterogeneity of the ILC family (WP3893) WikiPathways WP3893_r118859
Overview of proinflammatory and profibrotic mediators (WP5095) WikiPathways WP5095_r120801
Cytosolic DNA-sensing pathway (WP4655) WikiPathways WP4655_r123496
Transcripts
Accession Version MolecularType Name NCBI Comments
XM_047424062 1 mRNA transcript variant X3 NC_000009 Reference
XM_017015285 2 mRNA transcript variant X6 NC_000009 Reference
XM_047424061 1 mRNA transcript variant X2 NC_000009 Reference
XM_047424064 1 mRNA transcript variant X5 NC_000009 Reference
XM_047424060 1 mRNA transcript variant X1 NC_000009 Reference
XM_047424063 1 mRNA transcript variant X4 NC_000009 Reference
NM_001314044 2 mRNA transcript variant 4 NC_000009 Reference
NM_001314047 2 mRNA transcript variant 7 NC_000009 Reference
NM_033439 4 mRNA transcript variant 1 NC_000009 Reference
NM_001314046 2 mRNA transcript variant 6 NC_000009 Reference
NM_001199640 2 mRNA transcript variant 2 NC_000009 Reference
NM_001314048 2 mRNA transcript variant 8 NC_000009 Reference
NM_001199641 2 mRNA transcript variant 3 NC_000009 Reference
NM_001314045 2 mRNA transcript variant 5 NC_000009 Reference
NM_001353802 2 mRNA transcript variant 9 NC_000009 Reference