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PIGS

phosphatidylinositol glycan anchor biosynthesis class S
General Information
Name phosphatidylinositol glycan anchor biosynthesis class S
Alias
  • GPI transamidase component PIG-S
  • GPI transamidase subunit
  • phosphatidylinositol glycan, class S
  • phosphatidylinositol-glycan biosynthesis class S protein
Gene_family Glycosylphosphatidylinositol transamidase complex|Phosphatidylinositol glycan anchor biosynthesis
organism Homo sapiens
entrez_id 94005
location 17q11.2
transcript_count 1
exon_count 12
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
    Stringdb GPI transamidase component PIG-S; Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates; Belongs to the PIGS family
    nextProt Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
PIGS BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
PIGS BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID POMK GeneID BioGRID Affinity Capture-MS
PIGS BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID MAPK4 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID PRKN GeneID BioGRID Affinity Capture-MS
PIGS BioGRID PLD4 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID CLPP GeneID BioGRID Proximity Label-MS
PIGS BioGRID CCDC47 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID TMED10 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID VAPA GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
PIGS BioGRID RAB7A GeneID BioGRID Proximity Label-MS
PIGS BioGRID CANX GeneID BioGRID Affinity Capture-MS
PIGS BioGRID RHOF GeneID BioGRID Affinity Capture-MS
PIGS BioGRID RHOD GeneID BioGRID Affinity Capture-MS
PIGS BioGRID RAC2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID CDC42 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID RHOA GeneID BioGRID Affinity Capture-MS
PIGS BioGRID TMEM106B GeneID BioGRID Proximity Label-MS
PIGS BioGRID RB1CC1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID ORF1ab GeneID BioGRID Affinity Capture-MS
PIGS BioGRID CTSS GeneID BioGRID Affinity Capture-MS
PIGS BioGRID C4orf3 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID TMEM95 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID ADGRE4P GeneID BioGRID Affinity Capture-MS
PIGS BioGRID C15orf32 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID STARD3NL GeneID BioGRID Affinity Capture-MS
PIGS BioGRID TTYH1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID ENTPD7 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID SPPL2B GeneID BioGRID Affinity Capture-MS
PIGS BioGRID CFC1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID VAC14 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID SLC39A4 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID CSGALNACT2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID GPR173 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID GPRC5B GeneID BioGRID Affinity Capture-MS
PIGS BioGRID PIGT GeneID BioGRID Affinity Capture-MS; Co-fractionation
PIGS BioGRID PRSS50 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID LYPD3 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID FBXO2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID TSPAN15 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID B4GAT1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID B3GNT3 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID TSPAN5 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID SCAMP2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID HS2ST1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID VAPB GeneID BioGRID Affinity Capture-MS
PIGS BioGRID AP1G2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID VNN2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID PSCA GeneID BioGRID Affinity Capture-MS
PIGS BioGRID VIPR2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID TSPAN8 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID THY1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID SMPD2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID MME GeneID BioGRID Affinity Capture-MS
PIGS BioGRID HYAL1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID HMOX1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID HLA-DRB1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID GP9 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID LPAR1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID COX4I1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID ENTPD2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID CD7 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID ASPH GeneID BioGRID Affinity Capture-MS
PIGS BioGRID ART4 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID SYNE3 GeneID BioGRID Proximity Label-MS
PIGS BioGRID CALR3 GeneID BioGRID Proximity Label-MS
PIGS BioGRID LRRC59 GeneID BioGRID Proximity Label-MS
PIGS BioGRID FBXO6 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID SEC61B GeneID BioGRID Proximity Label-MS
PIGS BioGRID PDIA4 GeneID BioGRID Proximity Label-MS
PIGS BioGRID FAM20C GeneID BioGRID Affinity Capture-MS
PIGS BioGRID E5 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID E5a GeneID BioGRID Affinity Capture-MS
PIGS BioGRID Rnf183 GeneID BioGRID Proximity Label-MS
PIGS BioGRID orf1ab GeneID BioGRID Affinity Capture-MS
PIGS BioGRID HSCB GeneID BioGRID Affinity Capture-MS
PIGS BioGRID KRTAP2-3 GeneID BioGRID Two-hybrid
PIGS BioGRID NBPF19 GeneID BioGRID Two-hybrid
PIGS BioGRID NOTCH2NLA GeneID BioGRID Two-hybrid
PIGS BioGRID KRTAP10-9 GeneID BioGRID Two-hybrid
PIGS BioGRID KRTAP19-2 GeneID BioGRID Two-hybrid
PIGS BioGRID KRTAP6-3 GeneID BioGRID Two-hybrid
PIGS BioGRID KRTAP2-4 GeneID BioGRID Two-hybrid
PIGS BioGRID KRTAP9-2 GeneID BioGRID Two-hybrid
PIGS BioGRID KRTAP1-3 GeneID BioGRID Two-hybrid
PIGS BioGRID TRIP6 GeneID BioGRID Two-hybrid
PIGS BioGRID LMBR1L GeneID BioGRID Affinity Capture-MS
PIGS BioGRID OTULINL GeneID BioGRID Proximity Label-MS
PIGS BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID CA9 GeneID BioGRID Proximity Label-MS
PIGS BioGRID UNC93B1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID SLC15A3 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID VIRMA GeneID BioGRID Affinity Capture-MS
PIGS BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID RNF4 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID CPEB2 GeneID BioGRID Two-hybrid
PIGS BioGRID GPR89B GeneID BioGRID Affinity Capture-MS
PIGS BioGRID ACAP2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID SOAT1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID NDUFS1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID NDUFA9 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID Haus1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID PIGU GeneID BioGRID Affinity Capture-MS; Co-fractionation
PIGS BioGRID CNTROB GeneID BioGRID Affinity Capture-MS
PIGS BioGRID ATP5MK GeneID BioGRID Affinity Capture-MS
PIGS BioGRID YIPF5 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID TCTN2 GeneID BioGRID Proximity Label-MS
PIGS BioGRID MICALL2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID TCTN3 GeneID BioGRID Proximity Label-MS
PIGS BioGRID TMEM131 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID SF3B1 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID DNAJC8 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID DNAJA2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID PIGK GeneID BioGRID Affinity Capture-MS; Co-fractionation
PIGS BioGRID GPAA1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
PIGS BioGRID SF3A2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID PPM1A GeneID BioGRID Affinity Capture-MS
PIGS BioGRID MYH6 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID FANCD2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID ENPP6 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID KIRREL2 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID EGFR GeneID BioGRID Co-fractionation
PIGS BioGRID KRTAP10-3 GeneID BioGRID Two-hybrid
PIGS BioGRID KRTAP10-8 GeneID BioGRID Two-hybrid
PIGS BioGRID KRT40 GeneID BioGRID Two-hybrid
PIGS BioGRID MMS19 GeneID BioGRID Affinity Capture-MS
PIGS BioGRID SDHB GeneID BioGRID Co-fractionation
PIGS BioGRID LMAN1 GeneID BioGRID Co-fractionation
PIGS BioGRID HSPA1L GeneID BioGRID Co-fractionation
PIGS BioGRID ATP6V1B1 GeneID BioGRID Co-fractionation
StringDB
A B experiments database textmining combined score hadb nhadb
PIGS COL6A5 0 0 140 273 1 1
PIGS ALMS1 0 0 0 204 1 1
PIGS CCNK 0 0 0 180 1 1
PIGS GNPNAT1 0 0 0 286 1 1
PIGS RNASEL 0 0 57 150 1 1
PIGS MICU2 0 0 0 303 1 1
PIGS FAM58A 0 0 0 393 1 1
PIGS STIM1 0 0 150 203 1 2
PIGS VNN2 234 0 0 234 1 1
PIGS SRPR 0 0 282 354 1 1
PIGS GALM 0 0 137 280 1 1
PIGS SRPRB 0 0 376 484 1 1
PIGS PIGT 756 900 765 999 1 1
PIGS RAB39A 0 0 0 182 1 1
PIGS STRN 0 0 0 189 1 1
PIGS PRPF38B 0 0 0 206 1 1
PIGS PGAP1 0 900 0 962 1 1
PIGS PIGG 0 0 0 178 1 1
PIGS ENSG00000249967 0 0 602 621 1 1
PIGS PLEKHA4 270 0 0 270 1 1
PIGS OGFRL1 0 0 214 214 1 1
PIGS AIG1 0 0 0 260 1 1
PIGS PIBF1 0 0 165 187 1 1
PIGS CCNT2 0 0 0 173 1 1
PIGS STT3B 0 0 324 403 1 1
PIGS UNC119B 0 0 0 189 1 1
PIGS DNAJC8 415 0 0 414 1 1
PIGS DNAJC6 0 0 0 190 1 1
PIGS RHAG 0 0 226 345 1 1
PIGS RNF4 270 0 0 270 1 1
PIGS STRN3 0 0 0 189 1 1
PIGS SLC1A5 0 0 173 258 1 1
PIGS GFER 0 0 0 514 1 1
PIGS SLC38A7 0 0 0 232 1 1
PIGS CNTROB 265 0 0 265 1 1
PIGS EFCAB13 0 0 228 249 1 1
PIGS FANCD2 208 0 0 208 1 1
PIGS MCM9 0 0 124 178 1 1
PIGS MYO1A 0 0 123 155 1 1
PIGS LPAR1 0 0 180 197 1 1
PIGS CIB1 0 0 0 204 1 1
PIGS TESC 0 0 0 204 1 1
PIGS RSAD2 0 0 0 258 1 1
PIGS PIGB 0 0 0 628 1 1
PIGS EIF2AK3 0 0 0 150 1 2
PIGS CD47 0 0 120 241 1 2
PIGS KRTAP9-2 175 0 0 175 1 1
PIGS PRSS50 659 0 0 671 1 1
PIGS PIK3C2A 0 0 171 263 1 1
PIGS PIGO 0 650 0 745 1 1
PIGS ZNF384 0 0 0 602 1 1
PIGS ITIH1 0 0 262 325 1 1
PIGS LZTS1 0 0 0 236 1 1
PIGS CHP2 0 0 0 204 1 1
PIGS ATXN7L1 0 0 225 313 1 1
PIGS INTS1 0 0 0 235 1 1
PIGS ISYNA1 0 0 261 392 1 1
PIGS QKI 0 0 0 227 1 1
PIGS UNC119 0 0 0 260 1 1
PIGS TMEM131 218 0 0 218 1 1
PIGS PI4K2A 0 0 349 380 1 1
PIGS CCNG1 0 0 180 309 1 1
PIGS ADPGK 0 0 0 235 1 1
PIGS PTGIR 0 0 253 299 1 1
PIGS DNAJA2 128 0 0 161 1 1
PIGS GPR182 0 0 125 217 1 1
PIGS ERLIN1 0 0 321 389 1 1
PIGS PCDHA3 0 0 233 232 1 1
PIGS PIGL 0 0 0 424 1 1
PIGS CERS6 0 0 0 155 1 1
PIGS MICU3 0 0 0 303 1 1
PIGS NDUFA6 0 0 0 429 1 1
PIGS ALG3 0 0 0 830 1 1
PIGS STT3A 0 0 281 354 1 1
PIGS PRKCSH 0 0 0 174 1 1
PIGS SULT1C3 0 0 233 232 1 1
PIGS SAR1B 0 0 0 153 1 1
PIGS UGGT1 0 0 0 150 1 1
PIGS ARSK 0 0 450 480 1 1
PIGS UGGT2 0 0 0 150 1 1
PIGS MURC 0 0 148 187 1 1
PIGS PTDSS2 0 0 413 427 1 1
PIGS GPR89A 169 0 0 169 1 1
PIGS COG3 0 0 0 155 1 1
PIGS EXOC3L1 0 0 0 244 1 1
PIGS SHISA2 0 0 180 179 1 1
PIGS PIGQ 0 0 0 461 1 1
PIGS PIGU 797 900 0 993 1 1
PIGS GDE1 0 0 369 467 1 1
PIGS PIGA 0 0 0 549 1 1
PIGS TMEFF1 0 0 143 177 1 1
PIGS PCDHA10 0 0 244 243 1 1
PIGS MICALL2 198 0 0 198 1 1
PIGS PPP3R1 0 0 0 207 1 1
PIGS EIF3F 0 0 0 426 1 1
PIGS CASKIN2 0 0 205 276 1 1
PIGS ENSG00000273398 0 0 0 205 1 1
PIGS NDUFA9 210 0 0 215 1 1
PIGS YDJC 0 0 211 277 1 1
PIGS PAN3 0 0 0 256 1 1
PIGS G6PC3 0 0 120 272 1 1
PIGS PIGK 871 900 764 999 1 1
PIGS ABCA3 0 0 0 817 1 1
PIGS MYH6 198 0 0 198 1 1
PIGS NDUFS1 178 0 0 188 1 1
PIGS SLC5A10 0 0 424 527 1 1
PIGS MORC4 0 0 0 219 1 1
PIGS HSCB 270 0 0 270 1 1
PIGS SLC7A5 0 0 173 260 1 1
PIGS LAMB2 0 0 170 313 1 1
PIGS PCDHA6 0 0 202 202 1 1
PIGS MFSD6 0 0 0 154 1 1
PIGS EGFR 272 0 0 272 1 2
PIGS PCDHB14 0 0 218 219 1 1
PIGS PCDHB11 0 0 216 217 1 1
PIGS HNRNPU 0 0 167 193 1 1
PIGS CTSV 0 0 258 258 1 1
PIGS LMBR1L 270 0 0 270 1 1
PIGS AGO4 0 0 77 153 1 1
PIGS CYB561 0 0 404 521 1 1
PIGS ZBTB39 0 0 263 285 1 1
PIGS SOAT1 171 0 0 171 1 1
PIGS CCNT1 0 0 0 173 1 1
PIGS OVCA2 0 0 0 248 1 1
PIGS PIGF 0 650 0 739 1 1
PIGS ACP5 0 0 123 474 1 1
PIGS SF3A2 246 0 0 245 1 1
PIGS LBR 0 0 0 171 1 1
PIGS MICU1 0 0 0 303 1 1
PIGS LGMN 0 0 0 461 1 1
PIGS PPP2R3C 0 0 359 375 1 1
PIGS FAM214B 0 0 0 357 1 1
PIGS R3HDM2 0 0 218 266 1 1
PIGS TM7SF2 0 0 113 306 1 1
PIGS ALDOA 0 0 161 232 1 1
PIGS RAB33B 0 0 0 171 1 2
PIGS PIGP 0 0 0 302 1 1
PIGS PLD5 0 0 0 374 1 1
PIGS LMAN1 271 0 0 271 1 1
PIGS INPPL1 0 0 203 367 1 1
PIGS PCDHB12 0 0 224 225 1 1
PIGS R3HCC1L 0 0 0 186 1 1
PIGS SDHB 271 0 0 286 1 1
PIGS PLPPR1 0 0 211 265 1 1
PIGS HSPA1L 271 0 0 271 1 1
PIGS COG6 0 0 0 167 1 1
PIGS MORC1 0 0 0 219 1 1
PIGS CHP1 0 0 0 426 1 1
PIGS NCOA5 0 0 156 163 1 1
PIGS MT-CO3 0 0 74 157 1 1
PIGS PIDD1 0 0 241 319 1 1
PIGS KIRREL2 269 0 0 269 1 1
PIGS C7 0 0 0 461 1 1
PIGS ATP6V1B1 271 0 0 271 1 1
PIGS GANAB 0 0 0 152 1 1
PIGS KIAA1429 270 0 0 270 1 1
PIGS PLD4 0 0 0 472 1 1
PIGS RHCG 0 0 323 428 1 1
PIGS KIAA0195 0 0 318 351 1 1
PIGS EDEM3 0 0 294 356 1 1
PIGS PDCD10 0 0 0 548 1 1
PIGS C4BPA 0 0 81 282 1 1
PIGS IGSF10 0 0 160 179 1 1
PIGS GPAA1 483 900 767 997 1 1
PIGS BID 0 0 202 231 1 2
PIGS GANC 0 0 0 152 1 1
PIGS ATG9A 0 0 0 427 1 2
PIGS ENPP6 128 0 0 206 1 1
PIGS MIB2 0 0 0 216 1 1
PIGS PIGC 0 0 0 545 1 1
PIGS CPEB2 192 0 0 192 1 1
PIGS EIF4ENIF1 0 0 0 515 1 1
PIGS CIB4 0 0 0 204 1 1
PIGS TMPRSS6 0 0 0 521 1 1
PIGS ADTRP 0 0 0 260 1 1
PIGS ALG13 0 0 0 189 1 1
PIGS PLEKHH1 0 0 0 294 1 1
PIGS SEC23A 0 0 0 258 1 2
PIGS MRPL20 0 0 0 181 1 1
PIGS GAL3ST3 0 0 464 547 1 1
PIGS CTSH 0 0 210 252 1 1
PIGS PLAUR 0 900 0 900 1 1
PIGS GAK 0 0 0 189 1 1
PIGS CDH22 0 0 136 197 1 1
PIGS CD320 0 0 335 437 1 1
PIGS PPP3R2 0 0 0 204 1 1
PIGS FAM214A 0 0 0 237 1 1
PIGS ACAP2 256 0 0 307 1 1
PIGS PPP2R5B 0 0 325 470 1 1
PIGS PLEKHH2 0 0 0 294 1 1
PIGS FAM92B 0 0 235 254 1 1
PIGS MORC3 0 0 0 221 1 1
PIGS PIGM 0 0 0 610 1 1
PIGS R3HCC1 0 0 0 234 1 1
PIGS MORC2 0 0 0 219 1 1
PIGS SEC23B 0 0 0 267 1 2
PIGS PIK3IP1 0 0 306 372 1 1
PIGS CLUH 0 0 0 474 1 1
PIGS PIGV 0 0 0 453 1 1
PIGS PLD3 0 0 0 472 1 1
PIGS PCDHA5 0 0 267 312 1 1
PIGS MMS19 270 0 0 273 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005515 Molecular Function protein binding enables IPI
GO:0016255 Biological Process attachment of GPI anchor to protein involved_in IBA
GO:0016255 Biological Process attachment of GPI anchor to protein involved_in NAS
GO:0016255 Biological Process attachment of GPI anchor to protein involved_in TAS
GO:0042765 Cellular Component GPI-anchor transamidase complex part_of IBA
GO:0042765 Cellular Component GPI-anchor transamidase complex part_of IDA
GO:0042765 Cellular Component GPI-anchor transamidase complex part_of IPI
GO:0042765 Cellular Component GPI-anchor transamidase complex part_of TAS
GO:0005789 Cellular Component endoplasmic reticulum membrane located_in NAS
GO:0005789 Cellular Component endoplasmic reticulum membrane located_in TAS
GO:0016020 Cellular Component membrane located_in HDA
Pathways
Name DB ID
Attachment of GPI anchor to uPAR Reactome R-HSA-162791
Post-translational modification: synthesis of GPI-anchored proteins Reactome R-HSA-163125
Metabolism of proteins Reactome R-HSA-392499
Post-translational protein modification Reactome R-HSA-597592
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_033198 4 mRNA None NC_000017 Reference