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TP53INP1

tumor protein p53 inducible nuclear protein 1
General Information
Name tumor protein p53 inducible nuclear protein 1
Alias
  • tumor protein p53-inducible nuclear protein 1
  • p53-dependent damage-inducible nuclear protein 1
  • p53-inducible p53DINP1
  • stress-induced protein
Gene_family
organism Homo sapiens
entrez_id 94241
location 8q22.1
transcript_count 3
exon_count 6
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez Predicted to enable antioxidant activity. Involved in autophagic cell death; positive regulation of autophagy; and positive regulation of transcription, DNA-templated. Located in autophagosome; cytosol; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Stringdb Tumor protein p53-inducible nuclear protein 1; Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxyg [...]
    nextProt Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Interactions
NCBI
StringDB
Ontologies
Pathways
Name DB ID
Generic Transcription Pathway Reactome R-HSA-212436
Transcriptional Regulation by TP53 Reactome R-HSA-3700989
Regulation of TP53 Activity Reactome R-HSA-5633007
TP53 Regulates Transcription of Cell Death Genes Reactome R-HSA-5633008
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Reactome R-HSA-6803204
Regulation of TP53 Activity through Phosphorylation Reactome R-HSA-6804756
RNA Polymerase II Transcription Reactome R-HSA-73857
Gene expression (Transcription) Reactome R-HSA-74160
p53 transcriptional gene network (WP4963) WikiPathways WP4963_r122690
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_033285 4 mRNA transcript variant 1 NC_000008 Reference
NM_001135733 2 mRNA transcript variant 2 NC_000008 Reference
XM_011517386 3 mRNA transcript variant X1 NC_000008 Reference