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AIM2

absent in melanoma 2
General Information
Name absent in melanoma 2
Alias
  • interferon-inducible protein AIM2
Gene_family Pyrin and HIN domain family|Pyrin domain containing
organism Homo sapiens
entrez_id 9447
location 1q23.1-q23.2
transcript_count 8
exon_count 14
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]
    Stringdb Interferon-inducible protein AIM2; Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppr [...]
    nextProt Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages (PubMed:17726700, PubMed:19158675, PubMed:19158676, PubMed:19158679, PubMed:20566831). Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precursor and processing of interleukin-1 beta and interleukin-18 (PubMed:17726700, PubMed:19158675, PubMed:19158676, PubMed:19158679, PubMed:20566831). Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner (PubMed:17726700, PubMed:19158675, PubMed:19158676, PubMed:19158679, PubMed:20566831). Also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity (PubMed:16432157).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
AIM2 BioGRID PRKN GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID USP21 GeneID BioGRID Affinity Capture-Western
AIM2 BioGRID XRCC1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID UCHL1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID HIRA GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID NR2C2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID TFE3 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID NR2F2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID TFCP2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID TFAP4 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID TFAP2C GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID TFAP2A GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID TCF20 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID FSCN1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID SDCBP GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID SAFB GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID RREB1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID RNH1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID RING1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID TRIM27 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID UPF1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID RCN2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID RBBP7 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID PSMC1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID PML GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID NBN GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID MRE11 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID MOV10 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID MECP2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID MBD1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID MAZ GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID LIG3 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID JUN GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID HOXA13 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID HDAC2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID HDAC1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID GTF2I GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID MSH6 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID XRCC6 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID FOXC1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID EMD GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID EEF1B2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID CSNK2A2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID COPA GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID CHD4 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID CAMK2D GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ALDH3A2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ADAR GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID NKX2-4 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID RBM12B GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ZNF740 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ZSCAN25 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID LEMD2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ZNF384 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID C5orf24 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID CHMP4B GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID SAMD1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID LAS1L GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID SLTM GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID HMBOX1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID DDX50 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID BCL11B GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID IKZF5 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID NCOA5 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID BEND3 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID GATAD2B GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID RCC2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID STRBP GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ZNF444 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID BCL11A GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID THEM6 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID VRK3 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ZBTB44 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID CACYBP GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID POT1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID MTREX GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID PES1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ADNP GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID SATB2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID DNAJC9 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID CTCF GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID DDX39A GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID SUGP2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID RAD50 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID PARP2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ZBTB33 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID NUP153 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ZBTB39 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ZNF646 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID PHF14 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID SAFB2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID MDC1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID AIM2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID MTA2 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID MTA1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID H1-10 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID BANF1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID EIF3A GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID HAT1 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID SMARCA5 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID H2AC18 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ZNF148 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID ZNF711 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID XRCC5 GeneID BioGRID Affinity Capture-MS
AIM2 BioGRID NPM1 GeneID BioGRID Proximity Label-MS
AIM2 BioGRID ANP32B GeneID BioGRID Two-hybrid
AIM2 BioGRID RNF4 GeneID BioGRID Two-hybrid
AIM2 BioGRID TRIM11 GeneID BioGRID Affinity Capture-Western
AIM2 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western
AIM2 BioGRID APPBP2 GeneID BioGRID Two-hybrid
StringDB
A B experiments database textmining combined score hadb nhadb
AIM2 FOXP3 0 0 208 208 1 2
AIM2 TRIM14 0 0 161 195 1 1
AIM2 HLA-DOB 0 0 109 161 1 1
AIM2 POP4 0 0 108 198 1 1
AIM2 CXCL8 0 0 391 390 1 2
AIM2 ENSG00000268500 0 0 123 165 1 1
AIM2 TICAM2 0 0 97 153 1 1
AIM2 TBK1 0 0 630 636 1 2
AIM2 SART3 0 0 136 159 1 1
AIM2 CLEC5A 0 0 171 171 1 1
AIM2 CHTOP 0 0 0 155 1 1
AIM2 IL1B 0 0 769 790 1 2
AIM2 CINP 0 0 97 191 1 1
AIM2 OAS1 0 0 337 370 1 1
AIM2 HIF1A 0 0 167 173 1 2
AIM2 JAK1 0 0 260 260 1 2
AIM2 ASTE1 0 0 378 378 1 1
AIM2 TRIM27 270 0 49 297 1 1
AIM2 IKBKE 0 0 181 256 1 1
AIM2 MGAT5 0 0 170 169 1 1
AIM2 HERC5 0 0 88 176 1 1
AIM2 ZNF384 270 0 0 270 1 1
AIM2 DPP8 0 0 135 157 1 1
AIM2 VDAC1 0 0 163 163 1 2
AIM2 BTN3A3 0 0 150 166 1 1
AIM2 POPDC3 0 0 0 461 1 1
AIM2 IFIT1 0 0 341 358 1 1
AIM2 RIPK3 0 0 378 397 1 2
AIM2 EXOC8 0 0 373 397 1 1
AIM2 WDR83 0 0 61 156 1 1
AIM2 MFN2 0 0 150 151 1 2
AIM2 EPHA2 0 0 264 287 1 1
AIM2 PRKCD 0 0 161 161 1 2
AIM2 CD2 0 0 89 155 1 1
AIM2 TEP1 0 0 150 174 1 1
AIM2 CTNNB1 0 0 170 169 1 2
AIM2 MSH6 270 0 82 301 1 1
AIM2 MAGED4B 0 0 503 503 1 1
AIM2 CTCF 270 0 0 270 1 1
AIM2 CD163 0 0 123 157 1 1
AIM2 ADAR 270 0 216 413 1 1
AIM2 DDX21 0 0 287 286 1 1
AIM2 BBOX1 0 0 242 260 1 1
AIM2 NLRP1 0 900 912 990 1 1
AIM2 APOBEC3G 0 0 218 276 1 1
AIM2 MTOR 0 0 167 167 1 2
AIM2 FMNL1 0 0 0 161 1 1
AIM2 IRF8 0 0 233 270 1 1
AIM2 SAMD9L 0 0 54 210 1 1
AIM2 RCC2 270 0 0 270 1 1
AIM2 EEF1B2 270 0 0 275 1 1
AIM2 CD40LG 0 0 204 223 1 1
AIM2 TFCP2 270 0 0 270 1 1
AIM2 DOCK2 0 0 150 181 1 1
AIM2 MARK4 0 0 113 174 1 1
AIM2 RNF112 0 0 0 153 1 1
AIM2 CAMK2D 270 0 0 270 1 1
AIM2 SECTM1 0 0 117 313 1 1
AIM2 TLR3 0 0 606 608 1 2
AIM2 TNFRSF1A 0 0 284 284 1 1
AIM2 GZMB 0 0 193 238 1 1
AIM2 RSAD2 0 0 358 408 1 1
AIM2 PARP9 0 0 0 354 1 1
AIM2 MAB21L2 0 0 0 204 1 1
AIM2 STAT1 0 0 464 496 1 2
AIM2 BRD2 0 0 0 189 1 1
AIM2 TCF20 270 0 0 275 1 1
AIM2 IL6 0 0 556 564 1 2
AIM2 EIF2AK3 0 0 142 170 1 2
AIM2 ATL1 0 0 265 265 1 1
AIM2 NCOA5 270 0 0 270 1 1
AIM2 NLRC3 0 0 470 491 1 1
AIM2 MPO 0 0 234 234 1 2
AIM2 STAT6 0 0 155 173 1 1
AIM2 MAPRE1 0 0 450 450 1 1
AIM2 CREB1 0 0 112 169 1 2
AIM2 GSDMD 0 720 788 939 1 2
AIM2 PCNP 0 0 107 200 1 1
AIM2 SSR2 0 0 144 167 1 1
AIM2 EMD 270 0 0 270 1 1
AIM2 CCL5 0 0 362 400 1 2
AIM2 CADM3 0 0 182 233 1 1
AIM2 DHX9 0 0 458 459 1 1
AIM2 IFNGR2 0 0 167 167 1 1
AIM2 IFNG 0 0 288 436 1 2
AIM2 BIRC2 0 0 217 253 1 1
AIM2 SPTA1 0 0 117 278 1 1
AIM2 MOV10 270 0 66 347 1 1
AIM2 RAD50 270 0 0 270 1 1
AIM2 DDX56 0 0 288 288 1 1
AIM2 MALT1 0 0 231 230 1 1
AIM2 BCL11B 270 0 0 283 1 1
AIM2 KCNJ11 0 0 284 284 1 1
AIM2 CXCL10 0 0 424 493 1 2
AIM2 CYLD 0 0 207 207 1 1
AIM2 CXCL13 0 0 113 152 1 1
AIM2 PYCARD 870 900 988 999 1 2
AIM2 CD1D 0 0 141 162 1 1
AIM2 TRIP12 0 0 46 251 1 1
AIM2 SLC22A31 0 0 0 224 1 1
AIM2 GSDMA 0 0 504 504 1 1
AIM2 TLR9 0 0 681 711 1 2
AIM2 CLEC4D 0 0 127 168 1 1
AIM2 PHF14 270 0 0 270 1 1
AIM2 IRF3 0 0 681 681 1 2
AIM2 MBD1 270 0 0 270 1 1
AIM2 PSMC1 270 0 0 270 1 1
AIM2 ERBB2 0 0 229 228 1 2
AIM2 ANXA5 0 0 156 155 1 2
AIM2 NLRP7 0 0 686 718 1 1
AIM2 SPRYD4 0 0 0 151 1 1
AIM2 GBP2 0 0 408 449 1 1
AIM2 RELA 0 0 218 218 1 2
AIM2 AKT1 0 0 278 278 1 2
AIM2 BCL2L1 0 0 171 171 1 2
AIM2 HIRA 270 0 0 270 1 1
AIM2 SP140 0 0 244 402 1 1
AIM2 EVPL 0 0 150 179 1 1
AIM2 CSF2 0 0 341 341 1 1
AIM2 LY96 0 0 294 324 1 1
AIM2 STAT4 0 0 123 215 1 1
AIM2 SAFB 270 0 0 285 1 1
AIM2 FAS 0 0 160 174 1 2
AIM2 TLR10 0 0 260 368 1 1
AIM2 CLEC7A 0 0 405 420 1 1
AIM2 CARD8 0 900 398 939 1 1
AIM2 IFIT3 0 0 246 328 1 1
AIM2 TRIM25 0 0 292 318 1 1
AIM2 CD4 0 0 456 467 1 2
AIM2 GABARAPL2 0 0 180 179 1 2
AIM2 PANX1 0 0 468 468 1 1
AIM2 NLRC4 0 720 988 997 1 2
AIM2 OAS2 0 0 209 313 1 1
AIM2 IKBKB 0 0 297 297 1 2
AIM2 GAPDH 0 0 325 325 1 2
AIM2 ABCF1 0 0 103 153 1 1
AIM2 ANP32B 240 0 0 239 1 1
AIM2 RUNX2 0 0 45 193 1 2
AIM2 TLR4 0 0 607 616 1 2
AIM2 PML 270 0 142 357 1 2
AIM2 XIAP 0 0 195 207 1 2
AIM2 NBR1 0 0 180 179 1 2
AIM2 IFITM1 0 0 164 163 1 1
AIM2 TNF 0 0 556 581 1 2
AIM2 TANK 0 0 331 331 1 2
AIM2 ADNP 270 0 0 270 1 1
AIM2 SLAMF7 0 0 0 165 1 1
AIM2 RNF25 0 0 54 152 1 1
AIM2 TIRAP 0 0 391 390 1 1
AIM2 PRB1 0 0 203 203 1 1
AIM2 TAB2 0 0 205 205 1 2
AIM2 IFNA1 0 0 556 556 1 1
AIM2 PARK2 0 0 161 161 1 1
AIM2 IL18 0 0 806 816 1 2
AIM2 IL7 0 0 128 170 1 1
AIM2 IL1RN 0 0 282 302 1 1
AIM2 IFITM3 0 0 151 158 1 1
AIM2 MYC 0 0 193 193 1 2
AIM2 IL15 0 0 194 194 1 1
AIM2 IRGM 0 0 217 229 1 2
AIM2 IL1R1 0 0 504 504 1 1
AIM2 CASP2 0 0 398 404 1 1
AIM2 NAIP 0 540 712 865 1 1
AIM2 LAS1L 270 0 70 340 1 1
AIM2 IL2RA 0 0 74 163 1 1
AIM2 IFI27 0 0 166 165 1 1
AIM2 HERC6 0 0 81 162 1 1
AIM2 CD209 0 0 216 233 1 1
AIM2 RBM12B 270 0 0 270 1 1
AIM2 DHX33 0 900 348 932 1 1
AIM2 ACVR2A 0 0 210 210 1 1
AIM2 TFAP2C 270 0 0 270 1 1
AIM2 DFNB59 0 0 184 183 1 1
AIM2 RNF135 0 0 233 244 1 1
AIM2 TAB1 0 0 154 206 1 1
AIM2 DDX3X 0 720 218 785 1 1
AIM2 SLC15A4 0 0 152 151 1 1
AIM2 MX1 0 0 376 407 1 1
AIM2 MEFV 0 0 974 976 1 1
AIM2 RBBP7 270 0 0 270 1 1
AIM2 TFAP2A 270 0 0 270 1 1
AIM2 IFNAR1 0 0 492 496 1 1
AIM2 DDX39A 270 0 0 270 1 1
AIM2 SDCBP 270 0 46 301 1 1
AIM2 IL5 0 0 170 169 1 1
AIM2 TAX1BP1 0 0 150 235 1 2
AIM2 IL1R2 0 0 154 179 1 1
AIM2 LY75 0 0 136 186 1 1
AIM2 CASP10 0 0 157 177 1 1
AIM2 TNFAIP3 0 0 230 248 1 2
AIM2 DDX50 270 0 0 270 1 1
AIM2 PARP15 0 0 0 151 1 1
AIM2 MTA1 270 0 0 270 1 1
AIM2 TIGIT 0 0 68 161 1 1
AIM2 MDC1 270 0 0 270 1 1
AIM2 ADAMDEC1 0 0 105 155 1 1
AIM2 CLEC4A 0 0 112 161 1 1
AIM2 TXNIP 0 0 421 431 1 2
AIM2 IFNL2 0 0 165 165 1 1
AIM2 BCL2A1 0 0 74 153 1 1
AIM2 IFI16 0 0 933 253 1 1
AIM2 ZBTB39 270 0 0 270 1 1
AIM2 OAS3 0 0 100 166 1 1
AIM2 IFNL1 0 0 202 202 1 1
AIM2 IFI35 0 0 213 232 1 1
AIM2 CH25H 0 0 260 260 1 1
AIM2 DHX58 0 0 517 531 1 1
AIM2 OASL 0 0 181 244 1 1
AIM2 RBCK1 0 0 204 218 1 1
AIM2 NLRP12 0 0 681 681 1 1
AIM2 BRCA1 0 0 350 350 1 2
AIM2 CD80 0 0 218 275 1 2
AIM2 GBP5 0 0 517 647 1 1
AIM2 SAFB2 270 0 0 285 1 1
AIM2 DEFB4A 0 0 194 194 1 1
AIM2 IRF7 0 0 529 557 1 1
AIM2 SOCS1 0 0 210 210 1 1
AIM2 NLRP10 0 0 458 457 1 1
AIM2 BTK 0 0 124 167 1 1
AIM2 MECP2 270 0 0 276 1 1
AIM2 MARCH7 0 0 276 276 1 1
AIM2 PGAM5 0 0 155 154 1 1
AIM2 TLR1 0 0 459 498 1 1
AIM2 TREX1 0 0 49 191 1 1
AIM2 MYD88 0 0 604 606 1 2
AIM2 DEFB103A 0 0 134 157 1 1
AIM2 CFLAR 0 0 235 262 1 2
AIM2 EGFR 0 0 150 168 1 2
AIM2 PSTPIP1 0 0 315 348 1 1
AIM2 PRKDC 0 0 454 454 1 2
AIM2 LAMP1 160 0 195 305 1 2
AIM2 SARM1 0 0 181 182 1 1
AIM2 RNASEH2A 0 0 161 161 1 1
AIM2 TFAP4 270 0 0 270 1 1
AIM2 CHMP4B 270 0 0 270 1 2
AIM2 NLRP2 0 0 605 645 1 1
AIM2 FADD 0 0 336 336 1 2
AIM2 ESX1 0 0 426 459 1 1
AIM2 SATB2 270 0 0 270 1 1
AIM2 TRIM16 0 0 169 169 1 2
AIM2 SKIV2L2 270 0 0 286 1 1
AIM2 IRF9 0 0 339 339 1 1
AIM2 LCN2 0 0 182 181 1 1
AIM2 TP53 0 0 263 263 1 2
AIM2 DDX60 0 0 310 315 1 1
AIM2 HOXA13 270 0 0 270 1 1
AIM2 NCF1 0 0 101 154 1 1
AIM2 IRAK2 0 0 218 218 1 1
AIM2 GATAD2B 270 0 0 270 1 1
AIM2 ZBP1 0 0 612 677 1 1
AIM2 IFIT2 0 0 266 316 1 1
AIM2 HDAC2 270 0 0 270 1 1
AIM2 NUP153 270 0 0 292 1 1
AIM2 CD19 0 0 204 258 1 1
AIM2 NLRP4 0 0 556 568 1 1
AIM2 VRK3 270 0 60 300 1 1
AIM2 RREB1 270 0 0 270 1 1
AIM2 LSM14A 0 0 218 271 1 1
AIM2 CAMP 0 0 391 404 1 2
AIM2 CD274 0 0 234 291 1 2
AIM2 TIMD4 0 0 90 168 1 1
AIM2 CARD9 0 0 532 532 1 1
AIM2 EXO1 0 0 170 169 1 1
AIM2 PSTPIP2 0 0 157 156 1 1
AIM2 P2RX4 0 0 151 150 1 1
AIM2 CSF3 0 0 171 171 1 1
AIM2 TRIM65 0 0 150 185 1 1
AIM2 IRAK1 0 0 390 390 1 1
AIM2 COLEC12 0 0 112 204 1 1
AIM2 CARD18 0 0 322 329 1 1
AIM2 CYBA 0 0 160 159 1 1
AIM2 CTLA4 0 0 244 266 1 2
AIM2 THEM6 270 0 0 270 1 1
AIM2 RNASEL 0 0 337 337 1 1
AIM2 HPRT1 0 0 170 169 1 1
AIM2 IFI44 0 0 180 246 1 1
AIM2 APAF1 0 0 285 285 1 2
AIM2 NLRC5 0 0 617 628 1 1
AIM2 JAK2 0 0 167 167 1 2
AIM2 HPCA 0 0 0 248 1 1
AIM2 TXN 0 0 248 248 1 1
AIM2 IFNA2 0 0 218 231 1 1
AIM2 LCP1 0 0 0 197 1 1
AIM2 CD300C 0 0 170 195 1 1
AIM2 STAT3 0 0 298 298 1 2
AIM2 S100A10 0 0 51 216 1 1
AIM2 AGO2 0 0 375 375 1 2
AIM2 PTPN22 0 0 134 183 1 1
AIM2 IKZF5 270 0 0 315 1 1
AIM2 C1QTNF7 0 0 139 157 1 1
AIM2 CACYBP 270 0 0 270 1 1
AIM2 XRCC6 270 0 247 426 1 1
AIM2 HELZ2 0 0 0 202 1 1
AIM2 FBXL2 0 0 158 157 1 1
AIM2 NEK7 0 0 556 563 1 1
AIM2 GSDMC 0 0 171 171 1 1
AIM2 TYROBP 0 0 122 178 1 1
AIM2 DNASE1L2 0 0 156 155 1 1
AIM2 CASP7 0 0 305 312 1 1
AIM2 C5orf24 270 0 0 270 1 1
AIM2 IRF4 0 0 193 232 1 1
AIM2 IFNA21 0 0 210 210 1 1
AIM2 NLRP6 0 540 888 947 1 1
AIM2 VEGFA 0 0 160 159 1 2
AIM2 LRR1 0 0 174 173 1 1
AIM2 BST2 0 0 267 295 1 1
AIM2 MTA2 270 0 0 270 1 1
AIM2 ALB 0 0 212 212 1 2
AIM2 CASP8 0 0 799 804 1 2
AIM2 CD68 0 0 205 216 1 2
AIM2 SDHA 0 0 180 179 1 1
AIM2 SUGP2 270 0 0 270 1 1
AIM2 LRRFIP1 0 0 601 692 1 1
AIM2 CCL2 0 0 379 379 1 2
AIM2 ZBTB44 270 0 0 270 1 1
AIM2 CD276 0 0 150 169 1 1
AIM2 OTULIN 0 0 150 171 1 1
AIM2 CASP5 0 900 652 975 1 1
AIM2 IDO1 0 0 143 193 1 1
AIM2 CLEC19A 0 0 211 211 1 1
AIM2 BEND3 270 0 0 270 1 1
AIM2 IFI6 0 0 207 207 1 1
AIM2 CARD17 0 0 210 672 1 1
AIM2 IFI44L 0 0 95 181 1 1
AIM2 MSH3 0 0 155 154 1 1
AIM2 SYK 0 0 390 418 1 2
AIM2 NFKBIA 0 0 344 343 1 2
AIM2 ZBTB33 270 0 0 270 1 1
AIM2 BIRC3 0 0 125 196 1 1
AIM2 WT1 0 0 134 153 1 1
AIM2 CSNK2A2 270 0 0 282 1 1
AIM2 FCGR2A 0 0 166 190 1 1
AIM2 IL4 0 0 321 321 1 1
AIM2 SLC22A17 0 0 0 224 1 1
AIM2 CLEC4E 0 0 294 328 1 1
AIM2 LIG3 270 0 0 270 1 1
AIM2 LRRFIP2 0 0 242 317 1 1
AIM2 MB21D1 0 0 759 778 1 1
AIM2 IL18RAP 0 0 150 182 1 1
AIM2 MRE11A 270 0 108 338 1 1
AIM2 RNF26 0 0 150 168 1 1
AIM2 TRIM21 0 0 269 297 1 1
AIM2 CCL3 0 0 271 312 1 1
AIM2 CTSG 0 0 183 200 1 1
AIM2 ALDH3A2 270 0 0 270 1 1
AIM2 FCGR3B 0 0 150 174 1 1
AIM2 DDX41 0 0 681 686 1 1
AIM2 DDX58 0 0 758 773 1 1
AIM2 PYDC2 0 0 314 313 1 1
AIM2 AGER 0 0 370 370 1 2
AIM2 APOBEC3D 0 0 136 176 1 1
AIM2 TRADD 0 0 218 218 1 1
AIM2 ARFGEF1 0 0 0 183 1 1
AIM2 SP110 0 0 0 158 1 1
AIM2 IAPP 0 0 273 273 1 2
AIM2 TGFBR2 0 0 155 154 1 1
AIM2 MAVS 0 0 632 637 1 2
AIM2 TRAT1 0 0 392 407 1 1
AIM2 CCL4 0 0 204 251 1 1
AIM2 GBP1 0 0 270 340 1 1
AIM2 IL1A 0 0 519 519 1 1
AIM2 ATG7 0 0 204 204 1 2
AIM2 IRAK4 0 0 362 362 1 1
AIM2 RNF31 0 0 174 173 1 1
AIM2 CXCL2 0 0 212 212 1 1
AIM2 CHD4 270 0 0 270 1 1
AIM2 CCL20 0 0 193 193 1 1
AIM2 IL10 0 0 451 461 1 2
AIM2 FAM26F 0 0 108 170 1 1
AIM2 PRF1 0 0 235 273 1 1
AIM2 MX2 0 0 181 255 1 1
AIM2 CCR1 0 0 123 155 1 1
AIM2 USP18 0 0 161 179 1 1
AIM2 P2RX7 0 0 460 497 1 2
AIM2 GBP3 0 0 321 335 1 1
AIM2 ZNF148 270 0 0 270 1 1
AIM2 IFIH1 0 0 654 677 1 1
AIM2 SLC15A3 0 0 137 168 1 1
AIM2 GSDMB 0 0 157 156 1 1
AIM2 ISG15 0 0 339 353 1 2
AIM2 MAP1LC3B 0 0 125 159 1 2
AIM2 DNASE2 0 0 268 284 1 1
AIM2 NBN 270 0 0 270 1 1
AIM2 TBX21 0 0 97 153 1 1
AIM2 ULK1 0 0 174 174 1 2
AIM2 ZNF444 270 0 0 270 1 1
AIM2 PKN1 0 0 171 171 1 1
AIM2 ARL4D 0 0 194 208 1 1
AIM2 ELANE 0 0 181 181 1 1
AIM2 NMUR1 0 0 65 168 1 1
AIM2 ARG1 0 0 157 156 1 2
AIM2 MAPK8 0 0 176 175 1 2
AIM2 CXCR5 0 0 91 593 1 1
AIM2 BCL11A 270 0 0 271 1 1
AIM2 MAGEA3 0 0 193 193 1 2
AIM2 SAMD1 270 0 0 270 1 1
AIM2 CASR 0 0 194 194 1 2
AIM2 CCR7 0 0 142 205 1 1
AIM2 IKBKG 0 0 325 325 1 1
AIM2 XRCC1 270 0 0 270 1 1
AIM2 NLRP5 0 0 235 235 1 1
AIM2 SMARCA5 270 0 0 270 1 1
AIM2 SPI1 0 0 205 239 1 1
AIM2 TP53BP1 0 800 822 963 1 1
AIM2 IL17A 0 0 391 390 1 2
AIM2 CTSB 0 0 466 465 1 2
AIM2 PRTN3 0 0 210 220 1 1
AIM2 ZSCAN25 270 0 0 270 1 1
AIM2 LYN 0 0 125 151 1 1
AIM2 CYCS 0 0 233 232 1 2
AIM2 DFNA5 0 0 392 396 1 1
AIM2 DHX36 0 0 556 560 1 1
AIM2 TLR7 0 0 602 629 1 2
AIM2 CXCL11 0 0 156 200 1 1
AIM2 HMGB1 0 0 498 507 1 2
AIM2 IRF5 0 0 338 355 1 1
AIM2 IFNB1 0 0 668 673 1 1
AIM2 IL13RA2 0 0 242 410 1 1
AIM2 PYHIN1 0 0 689 222 1 1
AIM2 MAZ 270 0 0 270 1 1
AIM2 IL18BP 0 0 216 216 1 1
AIM2 CASP9 0 0 248 256 1 2
AIM2 RNH1 270 0 0 270 1 1
AIM2 TRAF6 0 0 403 403 1 2
AIM2 ITGAM 0 0 336 370 1 1
AIM2 P2RY2 0 0 170 169 1 1
AIM2 ANKRD22 0 0 181 230 1 1
AIM2 MAGEA1 0 0 469 469 1 1
AIM2 TLR8 0 0 519 550 1 1
AIM2 DEFB103B 0 0 132 155 1 1
AIM2 CXCL9 0 0 247 323 1 1
AIM2 CALCOCO2 0 0 214 214 1 2
AIM2 HSP90B1 0 0 134 167 1 1
AIM2 ATG5 0 0 322 321 1 2
AIM2 CCR2 0 0 218 252 1 2
AIM2 DDX1 0 0 270 270 1 1
AIM2 MVK 0 0 211 211 1 1
AIM2 NLRP14 0 0 294 313 1 1
AIM2 TRIM5 0 0 271 298 1 1
AIM2 PYDC1 0 0 458 466 1 1
AIM2 CX3CR1 0 0 166 165 1 1
AIM2 IRF1 0 0 465 484 1 2
AIM2 STAT2 0 0 315 323 1 1
AIM2 PMEL 0 0 406 406 1 1
AIM2 IRF2 0 0 206 206 1 1
AIM2 CXCR3 0 0 182 218 1 1
AIM2 C1orf141 0 0 161 161 1 1
AIM2 TYK2 0 0 241 240 1 1
AIM2 NOD1 0 0 602 607 1 2
AIM2 IFNA17 0 0 193 193 1 1
AIM2 TRIM11 270 0 456 628 1 1
AIM2 TMEM173 0 0 561 562 1 1
AIM2 FOXC1 270 0 0 270 1 1
AIM2 ACAD11 0 0 54 155 1 1
AIM2 SHARPIN 0 0 193 210 1 1
AIM2 PES1 270 0 0 270 1 1
AIM2 JUN 270 0 247 428 1 2
AIM2 LEMD2 270 0 0 275 1 1
AIM2 NLRP13 0 0 284 284 1 1
AIM2 TMPO 270 0 0 270 1 1
AIM2 NR2F2 270 0 0 270 1 1
AIM2 NAB2 0 0 0 236 1 1
AIM2 FCN1 0 0 60 182 1 1
AIM2 ENSG00000173366 0 0 681 705 1 1
AIM2 FSCN1 270 0 0 270 1 1
AIM2 CD86 0 0 243 292 1 1
AIM2 PARP2 270 0 0 270 1 1
AIM2 GZMA 0 0 141 174 1 1
AIM2 IL18R1 0 0 194 194 1 1
AIM2 NCALD 0 0 0 187 1 1
AIM2 TRAF3 0 0 392 392 1 2
AIM2 CPSF3 0 0 0 302 1 1
AIM2 HPCAL1 0 0 61 264 1 1
AIM2 APPBP2 226 0 0 225 1 1
AIM2 TOLLIP 0 0 175 175 1 1
AIM2 GBP4 0 0 86 151 1 1
AIM2 TNFSF10 0 0 209 242 1 2
AIM2 TLR2 0 0 602 614 1 2
AIM2 AIF1 0 0 155 185 1 2
AIM2 CASP1 747 900 989 999 1 2
AIM2 IL2 0 0 260 260 1 1
AIM2 TLR6 0 0 391 449 1 1
AIM2 STRBP 270 0 0 270 1 1
AIM2 POLR3F 0 0 118 205 1 1
AIM2 TRIM38 0 0 171 223 1 1
AIM2 BECN1 270 0 283 454 1 2
AIM2 CCL7 0 0 163 163 1 1
AIM2 DNAJC9 270 0 0 270 1 1
AIM2 SLAMF1 0 0 119 209 1 1
AIM2 IFNGR1 0 0 163 163 1 1
AIM2 KCNK6 0 0 150 169 1 1
AIM2 TFAM 0 0 155 154 1 2
AIM2 RIPK2 0 0 375 375 1 2
AIM2 CD8A 0 0 452 452 1 1
AIM2 UCHL1 270 0 0 270 1 2
AIM2 APOBEC3A 0 0 183 225 1 1
AIM2 RING1 270 0 0 270 1 1
AIM2 CALR 0 0 150 168 1 1
AIM2 USP50 0 0 134 152 1 1
AIM2 PSMB8 0 0 166 185 1 1
AIM2 TFE3 270 0 0 270 1 2
AIM2 UPF1 270 0 0 292 1 1
AIM2 EIF2AK2 270 0 234 435 1 2
AIM2 IRAK3 0 0 184 183 1 1
AIM2 IFNL3 0 0 164 163 1 1
AIM2 XAF1 0 0 96 208 1 1
AIM2 FCER1A 0 0 114 209 1 1
AIM2 MAGED4 0 0 502 502 1 1
AIM2 IL7R 0 0 95 195 1 1
AIM2 HMBOX1 270 0 0 270 1 1
AIM2 CCR5 0 0 164 221 1 1
AIM2 IL37 0 0 167 167 1 1
AIM2 PARP14 0 0 0 200 1 1
AIM2 CD69 0 0 125 156 1 1
AIM2 MNDA 0 0 764 232 1 1
AIM2 CCRL2 0 0 113 159 1 1
AIM2 SOCS3 0 0 160 159 1 1
AIM2 CLEC6A 0 0 241 292 1 1
AIM2 PQBP1 0 0 204 204 1 1
AIM2 CLEC9A 0 0 170 169 1 1
AIM2 FASLG 0 0 203 232 1 1
AIM2 TICAM1 0 0 379 379 1 2
AIM2 H1FX 270 0 0 298 1 1
AIM2 NLRP8 0 0 249 248 1 1
AIM2 HDAC1 270 0 49 276 1 2
AIM2 RIPK1 0 0 384 384 1 2
AIM2 COPA 270 0 0 270 1 1
AIM2 CSF1 0 0 262 262 1 1
AIM2 GABARAPL1 0 0 167 167 1 2
AIM2 OR6K6 0 0 57 314 1 1
AIM2 ZNF711 270 0 0 270 1 1
AIM2 HIGD1A 0 0 56 157 1 1
AIM2 UNC93B1 0 0 391 390 1 1
AIM2 ICAM1 0 0 217 235 1 2
AIM2 RALB 0 0 209 227 1 2
AIM2 BCL10 0 0 294 294 1 1
AIM2 MLKL 0 0 369 386 1 2
AIM2 ATG16L1 0 0 341 341 1 2
AIM2 BANF1 270 0 49 325 1 1
AIM2 NLRP9 0 900 401 943 1 1
AIM2 TRIM31 0 0 170 188 1 1
AIM2 CIITA 0 0 391 418 1 1
AIM2 SART1 0 0 324 323 1 1
AIM2 PTPRC 0 0 257 359 1 1
AIM2 NOD2 0 0 637 667 1 2
AIM2 CHUK 0 0 325 325 1 1
AIM2 RCN2 270 0 0 270 1 1
AIM2 S100A12 0 0 181 206 1 1
AIM2 NLRP11 0 0 216 226 1 1
AIM2 TLR5 0 0 460 471 1 1
AIM2 HAT1 270 0 0 270 1 1
AIM2 IL1RAP 0 0 193 193 1 1
AIM2 SAMHD1 0 0 324 338 1 1
AIM2 ZNF740 270 0 0 270 1 1
AIM2 XRCC5 270 0 144 348 1 1
AIM2 EIF3A 270 0 0 270 1 1
AIM2 EPSTI1 0 0 55 154 1 1
AIM2 ITGAX 0 0 292 326 1 1
AIM2 TAF1B 0 0 296 296 1 1
AIM2 IFNAR2 0 0 264 264 1 1
AIM2 CASP4 0 540 390 791 1 2
AIM2 RHOA 0 0 170 169 1 2
AIM2 CD1C 0 0 108 151 1 1
AIM2 NR2C2 270 0 53 354 1 1
AIM2 BRCC3 0 0 95 151 1 1
AIM2 MMP9 0 0 158 174 1 2
AIM2 B2M 0 0 123 165 1 1
AIM2 GTF2I 270 0 0 270 1 1
AIM2 SQSTM1 486 0 253 605 1 2
AIM2 FCGR2B 0 0 219 259 1 1
AIM2 GPR65 0 0 113 156 1 1
AIM2 TRIM22 0 0 150 205 1 1
AIM2 TRIM56 0 0 289 300 1 1
AIM2 CYBB 0 0 259 302 1 2
AIM2 RNF5 0 0 218 218 1 1
AIM2 CCDC13 0 0 86 184 1 1
AIM2 ATG12 0 0 187 187 1 2
AIM2 IL13 0 0 235 235 1 2
AIM2 INS 0 0 181 181 1 2
AIM2 ACTB 0 0 401 411 1 2
AIM2 CD40 0 0 244 277 1 2
AIM2 NLRX1 0 0 469 469 1 2
AIM2 HIST2H2AA 270 0 60 284 1 1
AIM2 CD8B 0 0 90 166 1 1
AIM2 SELL 0 0 124 228 1 1
AIM2 TNFSF13B 0 0 211 249 1 1
AIM2 SLTM 270 0 0 300 1 1
AIM2 GBP7 0 0 294 303 1 1
AIM2 PSMB9 0 0 123 172 1 1
AIM2 PTGS2 0 0 181 196 1 2
AIM2 CASP3 0 0 344 352 1 2
AIM2 NKX2-4 270 0 0 281 1 1
AIM2 SP100 0 0 162 224 1 1
AIM2 CRP 0 0 171 171 1 2
AIM2 ZNF646 270 0 0 270 1 1
AIM2 MUL1 0 0 155 154 1 2
AIM2 REL 0 0 166 184 1 2
AIM2 NLRP3 0 900 981 998 1 2
AIM2 HSP90AA1 0 0 181 201 1 2
AIM2 POT1 270 0 0 270 1 1
AIM2 CARD16 0 0 321 720 1 1
AIM2 CXCL1 0 0 295 295 1 2
AIM2 IL33 0 0 391 390 1 2
AIM2 LRRC3 0 0 251 264 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0140608 Molecular Function cysteine-type endopeptidase activator activity enables IDA
GO:0003690 Molecular Function double-stranded DNA binding enables IBA
GO:0003690 Molecular Function double-stranded DNA binding enables IDA
GO:0042802 Molecular Function identical protein binding enables IPI
GO:0038187 Molecular Function pattern recognition receptor activity enables IDA
GO:0005515 Molecular Function protein binding enables IPI
GO:0035591 Molecular Function signaling adaptor activity enables IDA
GO:0140970 Biological Process AIM2 inflammasome complex assembly involved_in IDA
GO:0006974 Biological Process DNA damage response involved_in ISS
GO:0043029 Biological Process T cell homeostasis involved_in ISS
GO:0002218 Biological Process activation of innate immune response involved_in IBA
GO:0002218 Biological Process activation of innate immune response involved_in IDA
GO:0007420 Biological Process brain development involved_in ISS
GO:0035458 Biological Process cellular response to interferon-beta involved_in IBA
GO:0071466 Biological Process cellular response to xenobiotic stimulus acts_upstream_of_or_within IDA
GO:0051607 Biological Process defense response to virus involved_in NAS
GO:0006955 Biological Process immune response involved_in TAS
GO:0006954 Biological Process inflammatory response involved_in IEA
GO:0045087 Biological Process innate immune response involved_in IEA
GO:0032088 Biological Process negative regulation of NF-kappaB transcription factor activity involved_in IDA
GO:0051898 Biological Process negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in ISS
GO:0070050 Biological Process neuron cellular homeostasis involved_in ISS
GO:0002221 Biological Process pattern recognition receptor signaling pathway involved_in NAS
GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IDA
GO:2001056 Biological Process positive regulation of cysteine-type endopeptidase activity involved_in IDA
GO:0002230 Biological Process positive regulation of defense response to virus by host involved_in ISS
GO:0050729 Biological Process positive regulation of inflammatory response involved_in NAS
GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in IDA
GO:0070269 Biological Process pyroptosis involved_in IDA
GO:0070269 Biological Process pyroptosis involved_in NAS
GO:1904270 Biological Process pyroptosome complex assembly involved_in IDA
GO:0050795 Biological Process regulation of behavior involved_in ISS
GO:0033209 Biological Process tumor necrosis factor-mediated signaling pathway involved_in IDA
GO:0097169 Cellular Component AIM2 inflammasome complex part_of IBA
GO:0097169 Cellular Component AIM2 inflammasome complex part_of IDA
GO:0097169 Cellular Component AIM2 inflammasome complex part_of IPI
GO:0005737 Cellular Component cytoplasm is_active_in IDA
GO:0005737 Cellular Component cytoplasm located_in IDA
GO:0005737 Cellular Component cytoplasm located_in NAS
GO:0005829 Cellular Component cytosol is_active_in IBA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005829 Cellular Component cytosol located_in TAS
GO:0005739 Cellular Component mitochondrion located_in IDA
GO:0005654 Cellular Component nucleoplasm is_active_in IBA
GO:0005654 Cellular Component nucleoplasm located_in IDA
GO:0035861 Cellular Component site of double-strand break is_active_in ISS
Pathways
Name DB ID
Innate Immune System Reactome R-HSA-168249
Immune System Reactome R-HSA-168256
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Reactome R-HSA-168643
Cytosolic sensors of pathogen-associated DNA Reactome R-HSA-1834949
Inflammasomes Reactome R-HSA-622312
The AIM2 inflammasome Reactome R-HSA-844615
Nucleotide-binding oligomerization domain (NOD) pathway (WP1433) WikiPathways WP1433_r122867
Cytosolic DNA-sensing pathway (WP4655) WikiPathways WP4655_r123496
Transcripts
Accession Version MolecularType Name NCBI Comments
XR_007064924 1 miscRNA transcript variant X5 NC_000001 Reference
XR_001737547 3 miscRNA transcript variant X6 NC_000001 Reference
XR_001737544 2 miscRNA transcript variant X1 NC_000001 Reference
XM_047434809 1 mRNA transcript variant X3 NC_000001 Reference
XM_047434808 1 mRNA transcript variant X2 NC_000001 Reference
NM_001348247 2 mRNA transcript variant 2 NC_000001 Reference
NM_004833 3 mRNA transcript variant 1 NC_000001 Reference
XM_047434811 1 mRNA transcript variant X4 NC_000001 Reference