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EI24

EI24 autophagy associated transmembrane protein
General Information
Name EI24 autophagy associated transmembrane protein
Alias
  • etoposide-induced protein 2.4 homolog
  • ectopic P-granules autophagy protein 4 homolog
  • etoposide induced 2.4
  • p53-induced gene 8 protein
  • tumor protein p53 inducible protein 8
Gene_family
organism Homo sapiens
entrez_id 9538
location 11q24.2
transcript_count 7
exon_count 13
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
    Stringdb Etoposide-induced protein 2.4 homolog; Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity); Belongs to the EI24 family
    nextProt Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
EI24 BioGRID Rab18 GeneID BioGRID Proximity Label-MS
EI24 BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
EI24 BioGRID TIPARP GeneID BioGRID Affinity Capture-MS
EI24 BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
EI24 BioGRID ORF1ab GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
EI24 BioGRID POMK GeneID BioGRID Affinity Capture-MS
EI24 BioGRID YIPF5 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID RTN4 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID CCDC47 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID NCLN GeneID BioGRID Affinity Capture-MS
EI24 BioGRID EMC9 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID COPB2 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID CANX GeneID BioGRID Affinity Capture-MS
EI24 BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID LPAR2 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID FZD7 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID VIPR2 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID VIPR1 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID SLC2A1 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID P2RY1 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID KCNK1 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID GPR35 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID ATP5PF GeneID BioGRID Affinity Capture-MS
EI24 BioGRID ATP5PB GeneID BioGRID Affinity Capture-MS
EI24 BioGRID ATP5F1C GeneID BioGRID Affinity Capture-MS
EI24 BioGRID ATP1A3 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID ASPH GeneID BioGRID Affinity Capture-MS
EI24 BioGRID MFSD4A GeneID BioGRID Affinity Capture-MS
EI24 BioGRID ATP5IF1 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID OPALIN GeneID BioGRID Affinity Capture-MS
EI24 BioGRID SLC39A4 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID GPR84 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID PILRB GeneID BioGRID Affinity Capture-MS
EI24 BioGRID YIPF3 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID NUP62 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID TSPAN15 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID ATG3 GeneID BioGRID Phenotypic Enhancement
EI24 BioGRID ATG7 GeneID BioGRID Phenotypic Enhancement
EI24 BioGRID LNPK GeneID BioGRID Proximity Label-MS
EI24 BioGRID HSD3B7 GeneID BioGRID Proximity Label-MS
EI24 BioGRID DERL1 GeneID BioGRID Proximity Label-MS
EI24 BioGRID ELOVL5 GeneID BioGRID Proximity Label-MS
EI24 BioGRID ERGIC1 GeneID BioGRID Proximity Label-MS
EI24 BioGRID LRRC59 GeneID BioGRID Proximity Label-MS
EI24 BioGRID HSD17B11 GeneID BioGRID Proximity Label-MS
EI24 BioGRID B3GAT1 GeneID BioGRID Proximity Label-MS
EI24 BioGRID TMT1A GeneID BioGRID Proximity Label-MS
EI24 BioGRID CKAP4 GeneID BioGRID Proximity Label-MS
EI24 BioGRID SEC61B GeneID BioGRID Proximity Label-MS
EI24 BioGRID BCAP31 GeneID BioGRID Proximity Label-MS
EI24 BioGRID REEP5 GeneID BioGRID Proximity Label-MS
EI24 BioGRID SEC62 GeneID BioGRID Proximity Label-MS
EI24 BioGRID STIM1 GeneID BioGRID Proximity Label-MS
EI24 BioGRID SSR1 GeneID BioGRID Proximity Label-MS
EI24 BioGRID RPN2 GeneID BioGRID Proximity Label-MS
EI24 BioGRID RPN1 GeneID BioGRID Proximity Label-MS
EI24 BioGRID RAB5C GeneID BioGRID Proximity Label-MS
EI24 BioGRID PRKN GeneID BioGRID Affinity Capture-MS
EI24 BioGRID MARCKS GeneID BioGRID Proximity Label-MS
EI24 BioGRID LAMP2 GeneID BioGRID Proximity Label-MS
EI24 BioGRID ATP2A1 GeneID BioGRID Proximity Label-MS
EI24 BioGRID E5a GeneID BioGRID Affinity Capture-MS
EI24 BioGRID HSCB GeneID BioGRID Affinity Capture-MS
EI24 BioGRID CCR8 GeneID BioGRID Two-hybrid
EI24 BioGRID TMED8 GeneID BioGRID Two-hybrid
EI24 BioGRID TMEM14B GeneID BioGRID Two-hybrid
EI24 BioGRID RABAC1 GeneID BioGRID Two-hybrid
EI24 BioGRID PGRMC2 GeneID BioGRID Two-hybrid
EI24 BioGRID BNIP2 GeneID BioGRID Two-hybrid
EI24 BioGRID OTULINL GeneID BioGRID Proximity Label-MS
EI24 BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID UNC93B1 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID SLC15A3 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID H4C1 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID HDAC2 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID NRAS GeneID BioGRID Proximity Label-MS
EI24 BioGRID KRAS GeneID BioGRID Proximity Label-MS
EI24 BioGRID RNF4 GeneID BioGRID Affinity Capture-MS
EI24 BioGRID IFT70B GeneID BioGRID Affinity Capture-MS
EI24 BioGRID RALB GeneID BioGRID Affinity Capture-MS
EI24 BioGRID STOM GeneID BioGRID Affinity Capture-MS
EI24 BioGRID TCTN3 GeneID BioGRID Proximity Label-MS
StringDB
A B experiments database textmining combined score hadb nhadb
EI24 ERRFI1 0 0 92 157 1 1
EI24 NAB2 0 0 113 168 1 1
EI24 AMFR 0 0 95 171 1 1
EI24 SNX4 0 0 122 163 1 2
EI24 STOM 180 0 0 179 1 1
EI24 STT3A 0 0 118 151 1 1
EI24 MPZL1 0 0 125 218 1 1
EI24 BECN1 0 0 233 334 1 2
EI24 CHST13 0 0 0 207 1 1
EI24 SNAP29 0 0 156 216 1 2
EI24 CHEK1 0 0 167 211 1 2
EI24 PHB 0 0 439 450 1 1
EI24 CWF19L1 0 0 95 235 1 1
EI24 ULK2 0 0 234 248 1 2
EI24 CCDC130 0 0 0 210 1 1
EI24 CDKN2B 0 0 47 195 1 1
EI24 SPATA18 0 0 155 162 1 1
EI24 PMAIP1 0 0 219 301 1 2
EI24 RABAC1 171 0 0 171 1 1
EI24 RPS21 0 0 0 218 1 1
EI24 IGFBP3 0 0 235 353 1 2
EI24 MAST3 0 0 175 300 1 1
EI24 KRAS 128 0 113 220 1 2
EI24 GJC1 0 0 72 170 1 1
EI24 CCT7 0 0 123 179 1 1
EI24 IGFBP4 0 0 72 171 1 1
EI24 RPS11 0 0 0 217 1 1
EI24 TATDN3 0 0 136 187 1 1
EI24 KPNA2 0 0 138 169 1 1
EI24 ATG16L1 0 0 142 180 1 2
EI24 STK24 0 0 72 167 1 1
EI24 ACAD8 0 0 166 165 1 1
EI24 RAB2B 0 0 0 181 1 1
EI24 RALB 172 0 0 171 1 2
EI24 CCNB2 0 0 97 178 1 1
EI24 GNB1 0 0 95 151 1 1
EI24 TMEM41A 0 0 138 177 1 1
EI24 VPS16 0 0 122 186 1 1
EI24 GABARAPL1 0 0 171 235 1 2
EI24 CDKN1A 0 0 219 224 1 2
EI24 ATG9A 0 0 187 187 1 2
EI24 CCNG1 0 0 234 263 1 1
EI24 CDKN2A 0 0 92 154 1 2
EI24 GUCY1A3 0 0 96 182 1 1
EI24 KIAA1324 0 0 181 181 1 1
EI24 ATP6V1C1 0 0 122 160 1 1
EI24 PARN 0 0 75 168 1 1
EI24 C9orf41 0 0 315 548 1 1
EI24 ATG13 0 0 189 257 1 2
EI24 TNFRSF10B 0 0 220 273 1 2
EI24 ATG12 0 0 218 284 1 2
EI24 VWA5A 0 0 276 276 1 1
EI24 RNGTT 0 0 151 169 1 1
EI24 GTSE1 0 0 166 311 1 1
EI24 SQSTM1 0 0 181 255 1 2
EI24 ATG101 0 0 288 414 1 2
EI24 ATG4D 0 0 134 228 1 2
EI24 MUL1 0 0 193 234 1 2
EI24 CDC27 0 0 161 161 1 1
EI24 GPRIN1 0 0 195 200 1 1
EI24 SUGP2 0 0 218 218 1 1
EI24 CASP8 0 0 134 152 1 2
EI24 WIPI1 0 0 289 359 1 2
EI24 ALG1L2 0 0 402 402 1 1
EI24 TTC37 0 0 141 679 1 1
EI24 TRIM41 0 0 359 359 1 1
EI24 CYFIP2 0 0 184 183 1 1
EI24 KRTAP4-5 0 0 242 241 1 1
EI24 PTEN 0 0 134 179 1 2
EI24 PVRL1 0 0 70 172 1 1
EI24 C6orf62 0 0 251 250 1 1
EI24 GABARAP 0 0 167 231 1 2
EI24 CTNS 0 0 82 167 1 2
EI24 SOGA1 0 0 232 248 1 1
EI24 E2F3 0 0 141 202 1 1
EI24 TP53BP2 0 0 286 286 1 2
EI24 RCHY1 0 0 324 406 1 1
EI24 PGRMC2 117 0 0 182 1 1
EI24 TP53AIP1 0 0 205 205 1 1
EI24 C12orf5 0 0 209 209 1 1
EI24 CACNG7 0 0 181 323 1 1
EI24 NFE2L1 0 0 95 160 1 1
EI24 DRAM2 0 0 162 161 1 2
EI24 AMBRA1 0 0 217 234 1 2
EI24 BIRC3 0 0 193 237 1 1
EI24 FHL1 0 0 0 213 1 1
EI24 MDM4 0 0 181 210 1 1
EI24 TRIM26 0 0 125 611 1 1
EI24 TMEM47 0 0 0 212 1 1
EI24 REV3L 0 0 108 245 1 1
EI24 TNFRSF10C 0 0 96 158 1 1
EI24 ATG16L2 0 0 154 159 1 2
EI24 CDCP2 0 0 293 293 1 1
EI24 ZYX 0 0 0 167 1 1
EI24 PEX5L 0 0 161 343 1 1
EI24 ATG7 0 0 310 364 1 2
EI24 TIGD6 0 0 266 266 1 1
EI24 GUCY1B3 0 0 122 210 1 1
EI24 SESN2 0 0 181 204 1 2
EI24 MAP1LC3B 0 0 142 166 1 2
EI24 WISP3 0 0 96 161 1 1
EI24 C15orf57 0 0 280 280 1 1
EI24 ATG10 0 0 240 239 1 2
EI24 GRAMD1B 0 0 194 511 1 1
EI24 FXR1 0 0 75 327 1 1
EI24 SEC61G 0 0 48 294 1 1
EI24 MAP4K4 0 0 136 158 1 1
EI24 TRAPPC10 0 0 124 181 1 1
EI24 FN1 0 0 74 172 1 2
EI24 MANSC4 0 0 181 181 1 1
EI24 VPS33A 0 0 157 209 1 1
EI24 ULK1 0 0 247 279 1 2
EI24 PRKAR1B 0 0 123 258 1 1
EI24 NUCB1 0 0 81 156 1 1
EI24 GADD45B 0 0 101 158 1 1
EI24 ZNF717 0 0 242 241 1 1
EI24 OR6K2 0 0 155 154 1 1
EI24 ATG4A 0 0 261 353 1 2
EI24 IQCK 0 0 211 211 1 1
EI24 SH3GLB1 0 0 172 197 1 2
EI24 BMP2 0 0 66 165 1 1
EI24 BAI1 0 0 158 177 1 1
EI24 TP53BP1 0 0 49 556 1 1
EI24 MIB1 0 0 193 402 1 1
EI24 ANKRD22 0 0 156 285 1 1
EI24 GRAMD1A 0 0 0 250 1 1
EI24 KIAA1143 0 0 170 169 1 1
EI24 PCGF1 0 0 108 311 1 1
EI24 ATG5 0 0 309 335 1 2
EI24 NDUFAB1 0 0 0 375 1 1
EI24 STEAP3 0 0 208 369 1 1
EI24 TRAPPC9 0 0 113 266 1 1
EI24 CASP2 0 0 234 367 1 1
EI24 AEN 0 0 370 391 1 1
EI24 QSER1 0 0 235 446 1 1
EI24 RNF4 270 0 0 270 1 1
EI24 PRB4 0 0 261 261 1 1
EI24 NBR1 0 0 95 177 1 2
EI24 KIAA2018 0 0 212 348 1 1
EI24 PTMA 0 0 86 247 1 1
EI24 IGF1R 0 0 124 281 1 2
EI24 GLIPR2 0 0 144 176 1 2
EI24 ATP5G3 0 0 124 178 1 1
EI24 CACNG5 0 0 0 181 1 1
EI24 PPP1R2 0 0 292 297 1 1
EI24 LEO1 0 0 0 250 1 1
EI24 WDR45B 0 0 0 307 1 1
EI24 WIPI2 0 0 126 213 1 2
EI24 DRAM1 0 0 294 305 1 2
EI24 SMAD4 0 0 68 161 1 2
EI24 COX7A2 0 0 120 212 1 1
EI24 FHL3 0 0 98 464 1 1
EI24 PLEKHA4 270 0 0 270 1 1
EI24 TXNIP 0 0 134 268 1 2
EI24 ATG4B 0 0 67 183 1 2
EI24 COL26A1 0 0 164 163 1 1
EI24 GCDH 0 0 141 212 1 1
EI24 UVRAG 0 0 246 245 1 2
EI24 OR2T6 0 0 161 161 1 1
EI24 OGN 0 0 68 271 1 1
EI24 WDR45 0 0 213 455 1 2
EI24 PIGT 0 0 155 243 1 1
EI24 RB1CC1 0 0 265 281 1 2
EI24 GADD45A 0 0 323 338 1 1
EI24 PHLDA3 0 0 213 219 1 1
EI24 SESN1 0 0 218 229 1 1
EI24 RAB2A 0 0 90 223 1 1
EI24 MDM2 0 0 288 288 1 2
EI24 LRRTM2 0 0 117 239 1 1
EI24 TP53 0 0 413 429 1 2
EI24 RFWD2 0 0 139 238 1 1
EI24 PCDHGA10 0 0 294 294 1 1
EI24 PRR23C 0 0 162 161 1 1
EI24 CCDC94 0 0 0 476 1 1
EI24 RPRM 0 0 213 297 1 1
EI24 GNL3 0 0 0 424 1 1
EI24 DDB2 0 0 206 260 1 1
EI24 RPL36 0 0 0 208 1 1
EI24 PAGE4 0 0 171 171 1 1
EI24 CRADD 0 0 125 217 1 1
EI24 EPG5 0 0 654 840 1 2
EI24 HSCB 270 0 0 270 1 1
EI24 TP53I3 0 800 323 867 1 1
EI24 CHST11 0 0 0 207 1 1
EI24 GNL3L 0 0 0 207 1 1
EI24 PSMA3 0 0 103 186 1 1
EI24 ZNF772 0 0 325 325 1 1
EI24 CCNE1 0 0 97 159 1 1
EI24 DMAP1 0 0 103 167 1 1
EI24 ATG2A 0 0 115 170 1 2
EI24 TBRG1 0 0 269 426 1 1
EI24 CHMP1A 0 0 233 249 1 1
EI24 SRRM3 0 0 235 235 1 1
EI24 GCAT 0 0 141 441 1 1
EI24 OR9G4 0 0 181 181 1 1
EI24 STX17 0 0 232 246 1 2
EI24 LAPTM4B 0 0 150 181 1 2
EI24 TCHP 0 0 486 485 1 1
EI24 ATG2B 0 0 258 304 1 2
EI24 OR1J2 0 0 193 193 1 1
EI24 LATS2 0 0 123 270 1 1
EI24 CDC73 0 0 0 214 1 1
EI24 CRMP1 0 0 103 197 1 1
EI24 DMTN 0 0 136 158 1 1
EI24 MAP1LC3A 0 0 71 155 1 2
EI24 CDK2 0 0 125 218 1 2
EI24 IPO13 0 0 147 171 1 1
EI24 TSC2 0 0 142 160 1 2
EI24 DLC1 0 0 102 163 1 2
EI24 VDAC1 0 0 451 472 1 2
EI24 GABRB2 0 0 95 184 1 1
EI24 PIDD1 0 0 324 440 1 1
EI24 HIST1H4F 270 0 0 270 1 1
EI24 TPST1 0 0 157 164 1 1
EI24 ATG4C 0 0 320 394 1 2
EI24 SLC34A1 0 0 104 241 1 1
EI24 SHISA5 0 0 325 439 1 1
EI24 CCT3 0 0 102 155 1 1
EI24 ZNF518A 0 0 244 243 1 1
EI24 ENSG00000250232 0 0 0 336 1 1
EI24 TRIML2 0 0 219 219 1 1
EI24 HRNR 0 0 164 163 1 1
EI24 RTN3 0 0 144 178 1 1
EI24 PIK3C3 0 0 195 266 1 2
EI24 ZNF69 0 0 243 242 1 1
EI24 ATG3 0 0 253 303 1 2
EI24 SYVN1 0 0 96 164 1 1
EI24 DNMBP 0 0 170 239 1 1
EI24 UBXN11 0 0 182 326 1 1
EI24 FBXO3 0 0 119 254 1 1
EI24 CCNG2 0 0 135 230 1 1
EI24 VPS37A 0 0 154 206 1 1
EI24 BIRC5 0 0 112 285 1 2
EI24 OR52B2 0 0 167 167 1 1
EI24 PERP 0 0 262 663 1 1
EI24 PRR12 0 0 0 207 1 1
EI24 TRIM2 0 0 113 168 1 1
EI24 MAP1LC3B2 0 0 233 255 1 1
EI24 LMAN1 0 0 75 218 1 1
EI24 CCNE2 0 0 157 198 1 1
EI24 MDGA2 0 0 152 220 1 1
EI24 OR2A14 0 0 149 238 1 1
EI24 SIAH1 0 0 135 189 1 1
EI24 PAFAH1B2 0 0 156 155 1 1
EI24 CAPN15 0 0 218 352 1 1
EI24 PIK3R4 0 0 154 189 1 2
EI24 BCL2L1 0 0 457 457 1 2
EI24 NFKB1 0 0 71 169 1 2
EI24 OR52M1 0 0 154 153 1 1
EI24 ZMAT3 0 0 259 724 1 1
EI24 GPATCH4 0 0 347 347 1 1
EI24 GARNL3 0 0 272 551 1 1
EI24 ATG14 0 0 262 354 1 2
EI24 DUSP5 0 0 54 306 1 1
EI24 S100A16 0 0 253 267 1 1
EI24 VMP1 0 0 561 828 1 2
EI24 ASNS 0 0 67 166 1 1
EI24 CRIM1 0 0 113 205 1 1
EI24 GABARAPL2 0 0 167 217 1 2
Ontologies
ID Category Term Effect Evidence PubMed
GO:0061676 Molecular Function importin-alpha family protein binding enables IPI
GO:0005515 Molecular Function protein binding enables IPI
GO:0006915 Biological Process apoptotic process involved_in IEA
GO:0016236 Biological Process macroautophagy involved_in IBA
GO:0030308 Biological Process negative regulation of cell growth acts_upstream_of_or_within IDA
GO:0005794 Cellular Component Golgi apparatus located_in IDA
GO:0005829 Cellular Component cytosol located_in IDA
GO:0005783 Cellular Component endoplasmic reticulum is_active_in IBA
GO:0005783 Cellular Component endoplasmic reticulum located_in IDA
GO:0005789 Cellular Component endoplasmic reticulum membrane located_in IEA
GO:0016020 Cellular Component membrane located_in HDA
GO:0031965 Cellular Component nuclear membrane located_in IEA
Pathways
Name DB ID
miRNA regulation of p53 pathway in prostate cancer (WP3982) WikiPathways WP3982_r108115
Transcripts
Accession Version MolecularType Name NCBI Comments
NR_110770 2 miscRNA transcript variant 4 NC_000011 Reference
NR_110769 2 miscRNA transcript variant 5 NC_000011 Reference
XM_011543069 3 mRNA transcript variant X1 NC_000011 Reference
NM_001330419 2 mRNA transcript variant 6 NC_000011 Reference
NM_004879 5 mRNA transcript variant 1 NC_000011 Reference
XM_011543070 2 mRNA transcript variant X2 NC_000011 Reference
NM_001290135 2 mRNA transcript variant 3 NC_000011 Reference