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NR1D1

nuclear receptor subfamily 1 group D member 1
General Information
Name nuclear receptor subfamily 1 group D member 1
Alias
  • nuclear receptor subfamily 1 group D member 1
  • Rev-ErbAalpha
  • V-erbA-related protein 1
  • nuclear receptor Rev-ErbA-alpha
  • rev-erbA-alpha
Gene_family Nuclear receptor subfamily 1 group D
organism Homo sapiens
entrez_id 9572
location 17q21.1
transcript_count 1
exon_count 8
Location
by NCBI GRCh38.p14
Summary
    Entrez This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]
    Stringdb Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for [...]
    nextProt Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity).
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
NR1D1 BioGRID SPSB4 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
NR1D1 BioGRID SLFN11 GeneID BioGRID Affinity Capture-MS
NR1D1 BioGRID SPSB2 GeneID BioGRID Affinity Capture-MS
NR1D1 BioGRID CIAO2A GeneID BioGRID Affinity Capture-MS
NR1D1 BioGRID EEF1AKMT3 GeneID BioGRID Affinity Capture-MS
NR1D1 BioGRID NR1D2 GeneID BioGRID Affinity Capture-MS
NR1D1 BioGRID SHANK3 GeneID BioGRID Two-hybrid
NR1D1 BioGRID SPG21 GeneID BioGRID Two-hybrid
NR1D1 BioGRID TDO2 GeneID BioGRID Two-hybrid
NR1D1 BioGRID YAP1 GeneID BioGRID Affinity Capture-Western; Co-localization
NR1D1 BioGRID TFCP2 GeneID BioGRID Affinity Capture-Western
NR1D1 BioGRID INPP1 GeneID BioGRID Two-hybrid
NR1D1 BioGRID NR2E3 GeneID BioGRID FRET
NR1D1 BioGRID C1D GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
NR1D1 BioGRID NCOR2 GeneID BioGRID Reconstituted Complex
NR1D1 BioGRID APP GeneID BioGRID Reconstituted Complex
NR1D1 BioGRID NCOR1 GeneID BioGRID Phenotypic Enhancement; Two-hybrid
NR1D1 BioGRID MYCBP2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
NR1D1 BioGRID HUWE1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
NR1D1 BioGRID HDAC3 GeneID BioGRID Affinity Capture-Western
NR1D1 Protein NR2E3 GeneID HPRD
NR1D1 Protein NR1D1 GeneID HPRD
NR1D1 Protein NR1D2 GeneID HPRD
NR1D1 Protein NCOR1 GeneID HPRD
NR1D1 Protein NCOR2 GeneID HPRD
StringDB
A B experiments database textmining combined score hadb nhadb
NR1D1 HNF4A 0 0 420 279 1 1
NR1D1 PRDM6 0 0 0 160 1 1
NR1D1 C2orf80 0 0 134 267 1 1
NR1D1 ACLY 0 0 244 243 1 1
NR1D1 TCF12 0 0 66 233 1 1
NR1D1 RABGEF1 0 0 0 196 1 1
NR1D1 ALAS2 0 0 202 202 1 1
NR1D1 FBXW11 0 0 134 162 1 1
NR1D1 PRSS50 0 0 452 452 1 1
NR1D1 ACRBP 0 0 260 260 1 1
NR1D1 SLC35F3 0 0 90 183 1 1
NR1D1 SCD 0 0 263 279 1 1
NR1D1 ADAMTS17 0 0 62 204 1 1
NR1D1 CDC42 0 0 0 152 1 2
NR1D1 TFCP2 270 0 43 387 1 1
NR1D1 IRS4 0 0 0 162 1 1
NR1D1 MB 0 0 208 208 1 2
NR1D1 CRY1 0 0 906 921 1 1
NR1D1 RAPGEF6 0 0 124 217 1 1
NR1D1 DGAT2 0 0 267 289 1 1
NR1D1 BGLAP 0 0 66 169 1 1
NR1D1 USP2 0 0 294 394 1 1
NR1D1 APOE 0 0 186 203 1 2
NR1D1 ADCK3 0 0 167 185 1 1
NR1D1 MEF2B 0 0 0 161 1 1
NR1D1 FOXO3 0 0 151 432 1 2
NR1D1 SLC2A4 0 0 263 281 1 1
NR1D1 DIO2 0 0 233 249 1 1
NR1D1 TIMM8A 0 0 81 178 1 1
NR1D1 KIF24 0 0 0 188 1 1
NR1D1 KLF8 0 0 55 217 1 1
NR1D1 MSX2 0 0 0 212 1 1
NR1D1 FAM234A 0 0 0 248 1 1
NR1D1 AES 0 0 56 192 1 1
NR1D1 KCNV2 0 0 155 154 1 1
NR1D1 RAC2 0 0 0 165 1 1
NR1D1 YY1 0 0 74 216 1 1
NR1D1 SKP1 0 0 229 245 1 2
NR1D1 LCOR 0 0 94 207 1 1
NR1D1 DGKB 0 0 0 189 1 1
NR1D1 KDM5A 0 0 187 204 1 1
NR1D1 HMOX1 0 0 193 193 1 2
NR1D1 BIN1 0 0 73 158 1 1
NR1D1 MTNR1B 0 0 374 377 1 1
NR1D1 STAG3 0 0 0 179 1 1
NR1D1 SPRY4 0 0 81 160 1 1
NR1D1 AMPD3 0 0 139 160 1 1
NR1D1 KDSR 0 0 48 153 1 1
NR1D1 CEBPG 0 0 57 233 1 1
NR1D1 DGKG 0 0 69 270 1 1
NR1D1 THAP3 0 0 0 277 1 1
NR1D1 BRDT 0 0 107 171 1 1
NR1D1 ABCG8 0 0 127 151 1 1
NR1D1 VIP 0 0 242 304 1 1
NR1D1 MRO 0 0 142 175 1 1
NR1D1 GABRE 0 0 94 491 1 1
NR1D1 SLC2A5 0 0 144 165 1 1
NR1D1 KLF4 0 0 108 163 1 2
NR1D1 PRDM16 0 0 135 152 1 1
NR1D1 FOXA1 0 0 134 251 1 1
NR1D1 CIRBP 0 0 377 377 1 1
NR1D1 CYP8B1 0 0 322 321 1 1
NR1D1 INPP5D 0 0 50 214 1 1
NR1D1 CD4 0 0 160 159 1 2
NR1D1 CPT1A 0 0 213 213 1 1
NR1D1 AKT1 0 0 260 287 1 2
NR1D1 PRDM4 0 0 0 160 1 1
NR1D1 RASD2 0 0 76 158 1 1
NR1D1 PPARG 0 0 634 228 1 2
NR1D1 OPN1MW2 0 0 134 152 1 1
NR1D1 NPDC1 0 0 113 239 1 1
NR1D1 ZMAT3 0 0 0 189 1 1
NR1D1 SEC14L5 0 0 97 236 1 1
NR1D1 ERBB2 0 0 180 196 1 2
NR1D1 GYS2 0 0 359 370 1 1
NR1D1 CSNK2A3 0 0 201 201 1 1
NR1D1 ITFG3 0 0 0 248 1 1
NR1D1 TH 0 0 244 243 1 2
NR1D1 CHRDL1 0 0 61 155 1 1
NR1D1 DENR 0 0 70 275 1 1
NR1D1 NR1I2 0 0 451 211 1 1
NR1D1 NR5A2 0 0 358 219 1 1
NR1D1 TLR9 0 0 138 155 1 2
NR1D1 ALAS1 0 0 522 531 1 1
NR1D1 SMC4 0 0 43 197 1 1
NR1D1 TCP11L2 0 0 0 815 1 1
NR1D1 FOXO4 0 0 74 180 1 1
NR1D1 RBM48 0 0 49 152 1 1
NR1D1 TBCC 0 0 164 163 1 1
NR1D1 GPT 0 0 139 166 1 1
NR1D1 ID2 0 0 171 171 1 1
NR1D1 CERS4 0 0 95 150 1 1
NR1D1 ATOH1 0 0 0 156 1 1
NR1D1 ADAM2 0 0 282 282 1 1
NR1D1 BCL6 0 0 126 181 1 1
NR1D1 CCK 0 0 113 182 1 1
NR1D1 SIRT4 0 0 282 282 1 1
NR1D1 IGF1 0 0 188 188 1 2
NR1D1 ASMT 0 0 325 325 1 1
NR1D1 STRN 0 0 0 189 1 1
NR1D1 FOXL2 0 0 81 234 1 1
NR1D1 FABP1 0 0 134 151 1 1
NR1D1 ARNTL 0 900 915 993 1 1
NR1D1 CHRNE 0 0 0 327 1 1
NR1D1 ESRRB 0 0 321 192 1 1
NR1D1 PKM 128 0 74 158 1 1
NR1D1 SLC25A25 0 0 134 158 1 1
NR1D1 RDH8 0 0 82 168 1 1
NR1D1 UBASH3B 0 0 124 152 1 1
NR1D1 OPN1SW 0 0 95 168 1 1
NR1D1 FOXK2 0 0 71 257 1 1
NR1D1 BCL2A1 0 0 164 163 1 1
NR1D1 PROX1 0 0 161 161 1 1
NR1D1 TXNIP 0 0 108 177 1 2
NR1D1 FAM180B 0 0 125 315 1 1
NR1D1 RHOF 0 0 0 174 1 1
NR1D1 TLE2 0 0 49 266 1 1
NR1D1 CACNG2 0 0 90 182 1 1
NR1D1 FLVCR1 0 0 155 156 1 1
NR1D1 TFAP2A 0 0 0 175 1 1
NR1D1 TCP1 0 0 0 183 1 1
NR1D1 APOC3 0 0 430 438 1 1
NR1D1 NR0B1 0 0 248 290 1 1
NR1D1 CDC7 0 0 62 157 1 1
NR1D1 GCG 0 0 335 344 1 1
NR1D1 RBFOX3 0 0 57 223 1 1
NR1D1 TFAP2C 0 0 0 175 1 1
NR1D1 RPLP0 0 0 144 202 1 1
NR1D1 MIOX 0 0 134 252 1 1
NR1D1 MAGEC1 0 0 157 156 1 1
NR1D1 ZFAND5 0 0 0 159 1 1
NR1D1 ITM2C 0 0 0 165 1 1
NR1D1 NRIP1 0 900 372 935 1 1
NR1D1 PIGZ 0 0 0 164 1 1
NR1D1 ADAMTS4 0 0 124 202 1 1
NR1D1 SIN3A 0 0 181 205 1 1
NR1D1 BDNF 0 0 213 230 1 2
NR1D1 MEF2C 0 0 82 230 1 1
NR1D1 VDR 0 0 321 193 1 2
NR1D1 UCP3 0 0 350 364 1 1
NR1D1 STRN3 0 0 0 189 1 1
NR1D1 NR4A2 0 0 508 292 1 1
NR1D1 ARNT2 0 0 123 257 1 1
NR1D1 MSX1 0 0 48 217 1 1
NR1D1 TIPIN 0 0 240 239 1 1
NR1D1 OXTR 0 0 74 227 1 1
NR1D1 TNF 0 0 277 277 1 2
NR1D1 SMARCD1 0 0 244 243 1 1
NR1D1 PLCB1 0 0 57 163 1 1
NR1D1 HNRNPD 0 0 113 168 1 1
NR1D1 PRDM5 0 0 0 160 1 1
NR1D1 MYF6 0 0 125 160 1 1
NR1D1 CAT 0 0 137 154 1 2
NR1D1 RAB3IP 0 0 71 164 1 1
NR1D1 CLK1 0 0 326 355 1 1
NR1D1 MYCBP2 270 0 119 333 1 1
NR1D1 PAGE5 0 0 519 519 1 1
NR1D1 ABCG5 0 0 137 161 1 1
NR1D1 CCNE1 0 0 113 206 1 1
NR1D1 FADS2 0 0 144 220 1 1
NR1D1 HPRT1 0 0 175 175 1 1
NR1D1 CNTN4 0 0 0 229 1 1
NR1D1 RAD54B 0 0 0 203 1 1
NR1D1 GPAM 0 0 166 191 1 1
NR1D1 CHRNG 0 0 0 317 1 1
NR1D1 FOXA2 0 0 107 228 1 1
NR1D1 MRPL57 0 0 90 230 1 1
NR1D1 KLF9 0 0 217 278 1 1
NR1D1 TSPAN4 0 0 125 168 1 1
NR1D1 UROS 0 0 140 193 1 1
NR1D1 TMEM243 0 0 96 158 1 1
NR1D1 SFMBT2 0 0 50 215 1 1
NR1D1 DDB2 0 0 52 204 1 1
NR1D1 CCND1 0 0 227 243 1 2
NR1D1 HSF2 0 0 0 936 1 1
NR1D1 C11orf71 0 0 103 168 1 1
NR1D1 SREBF2 0 0 210 249 1 1
NR1D1 ULK3 0 0 90 178 1 2
NR1D1 NR5A1 0 0 274 195 1 1
NR1D1 HNRNPA3 0 0 49 152 1 1
NR1D1 CD36 0 0 113 187 1 2
NR1D1 PC 0 0 112 161 1 1
NR1D1 TMX3 0 0 74 234 1 1
NR1D1 PDLIM7 0 0 0 185 1 1
NR1D1 DVL2 0 0 94 170 1 2
NR1D1 HMGCR 0 0 260 260 1 1
NR1D1 PROK2 0 0 349 391 1 1
NR1D1 STARD3 0 0 113 175 1 1
NR1D1 SGK1 0 0 140 179 1 2
NR1D1 IRS1 0 0 123 270 1 2
NR1D1 CC2D1A 0 0 57 504 1 1
NR1D1 RRAD 0 0 0 189 1 1
NR1D1 EGR2 0 0 85 192 1 1
NR1D1 DRD1 0 0 134 155 1 1
NR1D1 RPS6KB1 0 0 125 222 1 2
NR1D1 FIZ1 0 0 170 260 1 1
NR1D1 GRP 0 0 167 207 1 2
NR1D1 DMTF1 0 0 92 281 1 1
NR1D1 HGNC:9982 0 0 71 172 1 1
NR1D1 NCOR1 846 600 989 999 1 1
NR1D1 CDK1 0 0 203 203 1 2
NR1D1 PGR 0 0 204 154 1 1
NR1D1 AHR 0 0 233 253 1 2
NR1D1 DHX30 0 0 134 173 1 1
NR1D1 SERPINE1 0 0 272 322 1 1
NR1D1 PER1 0 0 561 835 1 1
NR1D1 PPARGC1B 0 0 310 353 1 1
NR1D1 RFESD 0 0 57 261 1 1
NR1D1 NAMPT 0 0 492 515 1 2
NR1D1 MAGED1 0 0 161 161 1 1
NR1D1 IL10 0 0 167 167 1 2
NR1D1 OPHN1 0 0 890 890 1 1
NR1D1 CPT1C 0 0 194 194 1 1
NR1D1 NR1H4 0 0 500 248 1 1
NR1D1 ACTG1 0 0 181 181 1 1
NR1D1 FOSL2 0 0 97 162 1 1
NR1D1 GLIS1 0 0 0 221 1 1
NR1D1 RXRG 0 0 315 230 1 1
NR1D1 OGT 0 0 90 195 1 2
NR1D1 LHCGR 0 0 150 193 1 1
NR1D1 AGRP 0 0 241 358 1 1
NR1D1 DNAJC30 0 0 142 361 1 1
NR1D1 SOX10 0 0 0 158 1 1
NR1D1 PRDM9 0 0 0 160 1 1
NR1D1 ATM 0 0 136 363 1 2
NR1D1 WDR55 0 0 123 189 1 1
NR1D1 SULT2B1 0 0 0 196 1 1
NR1D1 UCP1 0 0 325 325 1 2
NR1D1 SREBF1 0 0 458 487 1 1
NR1D1 ZNF503 0 0 0 165 1 1
NR1D1 DNAJC11 0 0 0 248 1 1
NR1D1 RORB 0 0 765 255 1 1
NR1D1 B3GNT5 0 0 57 266 1 1
NR1D1 RORC 0 0 731 263 1 1
NR1D1 NFKBIA 0 0 167 189 1 2
NR1D1 LEP 0 0 413 428 1 1
NR1D1 RARB 0 0 209 167 1 1
NR1D1 TCF4 0 0 0 212 1 1
NR1D1 SLITRK6 0 0 96 296 1 1
NR1D1 PRKAA2 0 0 138 177 1 2
NR1D1 COLEC10 0 0 44 209 1 1
NR1D1 PLN 0 0 74 283 1 1
NR1D1 BHLHE41 0 0 765 983 1 1
NR1D1 MYOD1 0 0 193 248 1 1
NR1D1 ZNF326 0 0 170 175 1 1
NR1D1 PTEN 0 0 108 168 1 2
NR1D1 GC 0 0 46 473 1 1
NR1D1 PRKAG2 0 0 95 162 1 1
NR1D1 SLC6A3 0 0 154 243 1 1
NR1D1 MYBL2 0 0 61 156 1 1
NR1D1 YAP1 270 0 0 270 1 2
NR1D1 KCMF1 0 0 0 153 1 1
NR1D1 CRH 0 0 195 195 1 1
NR1D1 MT-ND1 0 0 53 153 1 1
NR1D1 HSF4 0 0 0 225 1 1
NR1D1 KLF11 0 0 108 218 1 1
NR1D1 RAC1 0 0 0 152 1 2
NR1D1 ESR1 0 0 364 214 1 2
NR1D1 GPR176 0 0 92 155 1 1
NR1D1 GPR149 0 0 65 272 1 1
NR1D1 PDK4 0 0 391 408 1 1
NR1D1 ANKMY2 0 0 95 336 1 1
NR1D1 SYNDIG1L 0 0 134 217 1 1
NR1D1 TLE3 0 0 66 199 1 1
NR1D1 SIRT1 0 0 563 574 1 2
NR1D1 MBNL1 0 0 46 225 1 1
NR1D1 PRL 0 0 194 194 1 1
NR1D1 ACOX1 0 0 139 166 1 1
NR1D1 MGAT1 0 0 0 288 1 1
NR1D1 DEDD2 0 0 0 167 1 1
NR1D1 CDCA7L 0 0 120 151 1 1
NR1D1 NONO 0 0 233 246 1 1
NR1D1 RARS 0 0 282 294 1 1
NR1D1 RARA 0 0 297 214 1 2
NR1D1 TBP 0 0 217 217 1 1
NR1D1 ULK1 0 0 70 165 1 2
NR1D1 TBX21 0 0 84 170 1 1
NR1D1 PRKCA 0 0 134 153 1 1
NR1D1 NR2E3 491 0 948 680 1 1
NR1D1 ALDH4A1 0 0 0 265 1 1
NR1D1 HMOX2 0 0 144 181 1 1
NR1D1 SLC24A5 0 0 0 189 1 1
NR1D1 COL4A6 0 0 47 191 1 1
NR1D1 LY6E 0 0 0 186 1 1
NR1D1 PIAS3 0 0 203 203 1 1
NR1D1 GDE1 0 0 118 275 1 1
NR1D1 HERPUD2 0 0 0 207 1 1
NR1D1 HES4 0 0 45 182 1 1
NR1D1 SOCS3 0 0 156 175 1 1
NR1D1 GNGT2 0 0 0 189 1 1
NR1D1 RHOD 0 0 0 210 1 1
NR1D1 MBNL2 0 0 0 168 1 1
NR1D1 LSAMP 0 0 0 224 1 1
NR1D1 HEY2 0 0 0 167 1 1
NR1D1 THRB 0 0 341 191 1 1
NR1D1 FOS 0 0 324 323 1 2
NR1D1 RAB11B 0 0 0 171 1 1
NR1D1 MSTN 0 0 143 247 1 1
NR1D1 STAT5A 0 0 136 155 1 1
NR1D1 ANGPTL4 0 0 166 165 1 1
NR1D1 GTF2F2 0 0 124 259 1 1
NR1D1 RXRA 0 0 301 241 1 1
NR1D1 BTRC 0 0 266 266 1 1
NR1D1 AVPR1A 0 0 235 253 1 1
NR1D1 FOXK1 0 0 0 233 1 1
NR1D1 SLC25A33 0 0 95 287 1 1
NR1D1 MTCL1 0 0 0 161 1 1
NR1D1 CAPN8 0 0 112 505 1 1
NR1D1 SYNCRIP 0 0 234 234 1 1
NR1D1 BBX 0 0 0 183 1 1
NR1D1 FOXO1 0 0 293 324 1 2
NR1D1 EPAS1 0 0 157 236 1 2
NR1D1 SRSF5 0 0 74 173 1 1
NR1D1 FMO5 0 0 156 155 1 1
NR1D1 WEE1 0 0 464 482 1 1
NR1D1 SERPINA7 0 0 134 168 1 1
NR1D1 NRL 0 0 347 392 1 1
NR1D1 TFCP2L1 0 0 0 193 1 1
NR1D1 NR6A1 0 0 401 230 1 1
NR1D1 MAPT 0 0 62 160 1 2
NR1D1 CYP11A1 0 0 154 155 1 1
NR1D1 PRDM8 0 0 0 191 1 1
NR1D1 PLA2R1 0 0 0 150 1 1
NR1D1 PIM3 0 0 0 210 1 1
NR1D1 ANKRD13B 0 0 137 219 1 1
NR1D1 CERS6 0 0 47 220 1 1
NR1D1 USMG5 0 0 66 158 1 1
NR1D1 MED1 0 0 145 162 1 1
NR1D1 CPOX 0 0 167 182 1 1
NR1D1 ENOX1 0 0 74 216 1 1
NR1D1 RXRB 0 0 293 266 1 1
NR1D1 GLIS3 0 0 0 376 1 1
NR1D1 LPIN1 0 0 261 277 1 2
NR1D1 ZNF703 0 0 0 171 1 1
NR1D1 GABRB3 0 0 57 220 1 1
NR1D1 NLRP3 0 0 159 158 1 2
NR1D1 HDAC9 0 0 134 220 1 1
NR1D1 BLZF1 0 0 0 216 1 1
NR1D1 HCRT 0 0 334 348 1 1
NR1D1 TRIB3 0 0 72 171 1 2
NR1D1 CXCL1 0 0 228 227 1 2
NR1D1 SLCO6A1 0 0 143 161 1 1
NR1D1 ESRRG 0 0 403 211 1 1
NR1D1 PTGS2 0 0 167 167 1 2
NR1D1 CCL11 0 0 126 163 1 1
NR1D1 NYAP2 0 0 0 239 1 1
NR1D1 TUB 0 0 0 154 1 1
NR1D1 SPON2 0 0 136 372 1 1
NR1D1 DLX3 0 0 63 150 1 1
NR1D1 PHACTR2 0 0 0 165 1 1
NR1D1 TSPAN9 0 0 0 253 1 1
NR1D1 SAGE1 0 0 454 454 1 1
NR1D1 LURAP1 0 0 103 245 1 1
NR1D1 GDF11 0 0 59 173 1 1
NR1D1 TIMELESS 0 0 653 659 1 1
NR1D1 NR2C2 0 0 358 265 1 1
NR1D1 MAP7D1 0 0 0 298 1 1
NR1D1 EDA2R 0 0 87 226 1 1
NR1D1 CRYM 0 0 75 189 1 1
NR1D1 ATP6AP1L 0 0 134 326 1 1
NR1D1 BHLHA15 0 0 54 362 1 1
NR1D1 SIK1 0 0 193 229 1 1
NR1D1 GSK3B 0 0 297 345 1 2
NR1D1 MTCH2 0 0 85 151 1 1
NR1D1 FABP4 0 0 181 181 1 1
NR1D1 RPS27A 270 0 0 270 1 1
NR1D1 PNPLA3 0 0 134 178 1 1
NR1D1 USF2 0 0 90 209 1 1
NR1D1 MEF2A 0 0 45 288 1 1
NR1D1 ACOT1 0 0 227 236 1 1
NR1D1 ZNF24 0 0 0 231 1 1
NR1D1 CDO1 0 0 0 189 1 1
NR1D1 CEBPB 0 0 284 414 1 2
NR1D1 DBP 0 0 710 889 1 2
NR1D1 TSPO 0 0 74 168 1 1
NR1D1 PRDM1 0 0 0 167 1 1
NR1D1 HDAC1 0 0 204 208 1 2
NR1D1 BRF2 0 0 160 280 1 1
NR1D1 RAB26 0 0 0 162 1 1
NR1D1 C2CD4D 0 0 0 195 1 1
NR1D1 TXNRD2 0 0 184 183 1 1
NR1D1 PROKR2 0 0 161 161 1 1
NR1D1 NCOA5 0 0 230 278 1 1
NR1D1 FRAT2 0 0 0 165 1 1
NR1D1 EPHX2 0 0 89 220 1 1
NR1D1 NPAS2 0 900 870 988 1 1
NR1D1 IL6 0 0 359 359 1 2
NR1D1 UCP2 0 0 193 205 1 2
NR1D1 HSFX1 0 0 0 183 1 1
NR1D1 ZNF331 0 0 0 206 1 1
NR1D1 FABP6 0 0 167 167 1 1
NR1D1 MYOG 0 0 186 310 1 1
NR1D1 THRA 0 0 603 344 1 1
NR1D1 BAIAP2L2 0 0 74 252 1 1
NR1D1 GABRB2 0 0 0 223 1 1
NR1D1 NOTCH1 0 0 103 153 1 2
NR1D1 POTEF 0 0 180 191 1 1
NR1D1 NDUFV3 0 0 0 161 1 1
NR1D1 ACOT2 0 0 167 177 1 1
NR1D1 MTOR 0 0 189 189 1 2
NR1D1 TBR1 0 0 0 150 1 1
NR1D1 CC2D1B 0 0 0 295 1 1
NR1D1 EGR1 0 0 269 352 1 2
NR1D1 LURAP1L 0 0 81 162 1 1
NR1D1 LIPE 0 0 234 253 1 1
NR1D1 MAP1LC3A 0 0 112 159 1 2
NR1D1 MYF5 0 0 113 290 1 1
NR1D1 DMTN 0 0 0 197 1 1
NR1D1 CTNNB1 0 0 180 222 1 2
NR1D1 IFRD2 0 0 82 222 1 1
NR1D1 VIPR2 0 0 392 392 1 1
NR1D1 CACNA1C 0 0 134 188 1 1
NR1D1 ACSL3 0 0 66 159 1 1
NR1D1 RHO 0 0 193 203 1 2
NR1D1 WNK3 0 0 48 259 1 1
NR1D1 NR1H3 0 0 325 223 1 1
NR1D1 RUNDC3B 0 0 73 168 1 1
NR1D1 IL1B 0 0 293 293 1 2
NR1D1 SIRT5 0 0 283 282 1 1
NR1D1 KCNIP2 0 0 66 214 1 1
NR1D1 GCK 0 0 212 246 1 1
NR1D1 HIF1A 0 0 211 235 1 2
NR1D1 YPEL5 0 0 67 153 1 1
NR1D1 MAGEC2 0 0 293 293 1 1
NR1D1 PEX11A 0 0 66 237 1 1
NR1D1 GBX2 0 0 0 159 1 1
NR1D1 SUMO2 0 0 450 468 1 1
NR1D1 GABPA 0 0 167 167 1 1
NR1D1 MTNR1A 0 0 390 390 1 1
NR1D1 LCORL 0 0 0 197 1 1
NR1D1 UBP1 0 0 0 174 1 1
NR1D1 GAPDH 0 0 369 383 1 2
NR1D1 TLR4 0 0 234 234 1 2
NR1D1 NMNAT1 0 0 90 231 1 1
NR1D1 CRIM1 0 0 44 180 1 1
NR1D1 CIPC 0 0 134 230 1 1
NR1D1 GPR171 0 0 59 268 1 1
NR1D1 GRHL1 0 0 0 162 1 1
NR1D1 APOA1 0 0 252 263 1 1
NR1D1 ADCYAP1 0 0 205 219 1 1
NR1D1 WDR73 0 0 82 192 1 1
NR1D1 ELF5 0 0 81 234 1 1
NR1D1 GNRHR 0 0 0 175 1 1
NR1D1 RELA 0 0 96 157 1 2
NR1D1 AOC3 0 0 0 308 1 1
NR1D1 RORA 0 900 801 926 1 1
NR1D1 FBXO32 0 0 202 224 1 2
NR1D1 HES1 0 0 52 215 1 2
NR1D1 CCNB1 0 0 170 188 1 1
NR1D1 CS 0 0 81 161 1 1
NR1D1 TEF 0 0 734 848 1 1
NR1D1 FGF21 0 0 360 360 1 2
NR1D1 MYT1L 0 0 60 177 1 1
NR1D1 ZFP2 0 0 233 248 1 1
NR1D1 HSF1 0 0 42 264 1 2
NR1D1 ZNF385A 0 0 81 333 1 1
NR1D1 SIRT2 0 0 283 282 1 2
NR1D1 RHOBTB2 0 0 0 150 1 1
NR1D1 UROD 0 0 134 156 1 1
NR1D1 CREBBP 0 0 164 194 1 1
NR1D1 PFKFB3 0 0 167 198 1 2
NR1D1 PDXK 0 0 296 296 1 1
NR1D1 SDHB 0 0 231 231 1 1
NR1D1 ESRRA 0 0 458 250 1 1
NR1D1 MBOAT7 0 0 0 163 1 1
NR1D1 CREB1 0 0 391 390 1 2
NR1D1 BRINP1 0 0 0 199 1 1
NR1D1 APOA4 270 0 184 388 1 1
NR1D1 HSD11B1 0 0 53 150 1 1
NR1D1 ACOT4 0 0 144 178 1 1
NR1D1 B3GALT4 0 0 61 159 1 1
NR1D1 AKT2 0 0 134 165 1 2
NR1D1 GNG4 0 0 150 368 1 1
NR1D1 ZNF423 0 0 52 152 1 1
NR1D1 NFIX 0 0 54 162 1 1
NR1D1 CIDEA 0 0 195 215 1 1
NR1D1 ATP13A5 0 0 75 155 1 1
NR1D1 PSMB3 0 0 166 165 1 1
NR1D1 MECP2 0 0 95 154 1 1
NR1D1 OGN 0 0 52 150 1 1
NR1D1 ODC1 0 0 102 164 1 1
NR1D1 TCF3 0 0 45 206 1 1
NR1D1 AQP1 0 0 124 162 1 1
NR1D1 POR 0 0 167 167 1 2
NR1D1 BRCA1 0 0 138 154 1 2
NR1D1 NPY 0 0 254 254 1 1
NR1D1 NANP 0 0 82 245 1 1
NR1D1 TDO2 238 0 113 312 1 1
NR1D1 SMAD4 0 0 54 157 1 2
NR1D1 SLC6A1 0 0 44 168 1 1
NR1D1 MYCN 0 0 167 174 1 1
NR1D1 RAB37 0 0 0 193 1 1
NR1D1 HDAC3 270 600 861 956 1 2
NR1D1 ITFG2 0 0 102 263 1 1
NR1D1 DLX2 0 0 112 245 1 1
NR1D1 MEF2D 0 0 109 322 1 2
NR1D1 ACSL1 0 0 127 151 1 1
NR1D1 SHANK1 0 0 0 173 1 1
NR1D1 FBXL3 0 0 733 741 1 1
NR1D1 FHL2 0 0 0 155 1 1
NR1D1 GPR50 0 0 218 218 1 1
NR1D1 PPP1R3C 0 0 181 218 1 1
NR1D1 DVL1 0 0 0 173 1 1
NR1D1 SOAT2 0 0 95 208 1 1
NR1D1 PIM1 0 0 0 189 1 1
NR1D1 G6PC 270 0 459 588 1 1
NR1D1 SLC7A1 0 0 203 203 1 1
NR1D1 CYP7B1 0 0 270 285 1 1
NR1D1 TFAP2B 0 0 0 175 1 1
NR1D1 NR4A3 0 0 391 219 1 1
NR1D1 ANO3 0 0 67 188 1 1
NR1D1 PCP2 0 0 153 173 1 1
NR1D1 HNF4G 0 0 235 218 1 1
NR1D1 ACACA 0 0 286 291 1 1
NR1D1 NR1I3 0 0 404 217 1 1
NR1D1 RARG 0 0 235 189 1 1
NR1D1 PLCB2 0 0 0 922 1 1
NR1D1 ZNF536 0 0 0 217 1 1
NR1D1 NR2F6 0 0 519 251 1 1
NR1D1 GNAT2 0 0 171 188 1 1
NR1D1 ARR3 0 0 66 152 1 1
NR1D1 CLOCK 0 900 900 990 1 2
NR1D1 NR0B2 0 0 501 530 1 1
NR1D1 FABP7 0 0 217 217 1 1
NR1D1 RARRES3 0 0 123 154 1 1
NR1D1 DGAT1 0 0 160 222 1 2
NR1D1 PPIG 0 0 142 180 1 1
NR1D1 PPP5C 0 0 108 163 1 1
NR1D1 KLB 0 0 181 181 1 1
NR1D1 MYC 0 0 320 319 1 2
NR1D1 PCK1 0 0 350 377 1 1
NR1D1 PPARGC1A 0 900 567 955 1 2
NR1D1 TPH1 0 0 210 210 1 1
NR1D1 USF1 0 0 193 229 1 1
NR1D1 NR2C1 0 0 395 272 1 1
NR1D1 TMEM60 0 0 0 189 1 1
NR1D1 SDHC 0 0 292 292 1 1
NR1D1 IGF1R 0 0 61 155 1 2
NR1D1 ZNF618 0 0 89 351 1 1
NR1D1 BRF1 0 0 0 290 1 1
NR1D1 NR2F1 0 0 391 245 1 1
NR1D1 SOX4 0 0 52 181 1 1
NR1D1 LRRC17 0 0 66 226 1 1
NR1D1 CDH26 0 0 0 359 1 1
NR1D1 TRIM23 0 0 0 156 1 1
NR1D1 SFPQ 0 0 151 152 1 1
NR1D1 CCAR2 0 0 285 284 1 1
NR1D1 DEAF1 0 0 0 259 1 1
NR1D1 STAT3 0 0 181 181 1 2
NR1D1 NCOA1 0 0 134 318 1 1
NR1D1 CES2 0 0 160 173 1 1
NR1D1 RBM3 0 0 203 232 1 1
NR1D1 ASB6 0 0 0 188 1 1
NR1D1 FNTA 0 0 207 207 1 1
NR1D1 GNAT1 0 0 170 187 1 1
NR1D1 SLC5A1 0 0 114 163 1 1
NR1D1 TSC22D3 0 0 269 274 1 1
NR1D1 GHRL 0 0 324 325 1 1
NR1D1 NR4A1 0 0 452 256 1 2
NR1D1 KLF10 0 0 229 309 1 1
NR1D1 RBFOX2 0 0 81 243 1 1
NR1D1 ANKRD42 0 0 134 357 1 1
NR1D1 PPARD 0 0 251 157 1 1
NR1D1 HUWE1 270 0 166 369 1 1
NR1D1 NMS 0 0 181 181 1 1
NR1D1 NCOR2 309 0 664 857 1 1
NR1D1 SLC2A2 0 0 293 310 1 1
NR1D1 NFKBIZ 0 0 72 322 1 1
NR1D1 DDIT3 0 0 63 210 1 2
NR1D1 CHAF1B 0 0 43 166 1 1
NR1D1 INSIG1 0 0 183 242 1 1
NR1D1 NR1H2 0 0 333 248 1 1
NR1D1 HMBS 0 0 153 152 1 1
NR1D1 TP53 0 0 283 282 1 2
NR1D1 CCRN4L 0 0 594 602 1 1
NR1D1 MIF4GD 0 0 0 252 1 1
NR1D1 MAOA 0 0 268 268 1 1
NR1D1 STAU1 0 0 0 189 1 1
NR1D1 LIPI 0 0 210 216 1 1
NR1D1 NFIL3 0 0 791 828 1 1
NR1D1 LGALS4 0 0 294 294 1 1
NR1D1 MAF 0 0 135 221 1 1
NR1D1 FKBP5 0 0 205 225 1 1
NR1D1 TSC22D1 0 0 84 231 1 1
NR1D1 AANAT 0 0 470 470 1 1
NR1D1 DRD2 0 0 136 159 1 1
NR1D1 NR3C2 0 0 253 204 1 1
NR1D1 ABCA1 0 0 193 210 1 2
NR1D1 GABRB1 0 0 0 207 1 1
NR1D1 FECH 0 0 232 280 1 1
NR1D1 FETUB 0 0 49 231 1 1
NR1D1 PGAP3 0 0 90 181 1 1
NR1D1 LONRF3 0 0 141 206 1 1
NR1D1 HMGCS2 0 0 156 174 1 1
NR1D1 SIRT6 0 0 323 339 1 2
NR1D1 HOXD1 0 0 0 215 1 1
NR1D1 SYT9 0 0 55 217 1 1
NR1D1 CERS2 0 0 54 267 1 1
NR1D1 CRX 0 0 326 393 1 1
NR1D1 HLF 0 0 564 678 1 1
NR1D1 PPOX 0 0 171 177 1 1
NR1D1 SYBU 0 0 60 407 1 1
NR1D1 GPR20 0 0 0 187 1 1
NR1D1 HSD17B11 0 0 91 173 1 1
NR1D1 MLXIPL 0 0 265 265 1 1
NR1D1 OLFML2B 0 0 67 167 1 1
NR1D1 CSNK2A2 0 0 163 163 1 1
NR1D1 EP300 0 900 414 941 1 2
NR1D1 PGRMC2 0 0 134 157 1 1
NR1D1 INPP1 271 0 57 309 1 1
NR1D1 RNF123 0 0 0 205 1 1
NR1D1 AVPR1B 0 0 66 163 1 1
NR1D1 IFI44L 0 0 0 206 1 1
NR1D1 ONECUT1 0 0 628 644 1 1
NR1D1 SOX15 0 0 95 185 1 1
NR1D1 SMAD3 0 0 116 163 1 2
NR1D1 ABCB6 0 0 94 188 1 1
NR1D1 PHACTR1 0 0 0 203 1 1
NR1D1 CRY2 0 0 870 991 1 1
NR1D1 CCL2 0 0 270 270 1 2
NR1D1 CDC23 0 0 52 156 1 1
NR1D1 ALB 0 0 283 301 1 2
NR1D1 ZMIZ2 0 0 0 153 1 1
NR1D1 CREB3L3 0 0 173 270 1 1
NR1D1 CUL1 0 0 137 160 1 1
NR1D1 HERPUD1 0 0 116 348 1 1
NR1D1 SNPH 0 0 0 154 1 1
NR1D1 NPAS1 0 0 56 175 1 1
NR1D1 CSNK1D 0 0 655 690 1 1
NR1D1 ZNF436 0 0 63 248 1 1
NR1D1 TRAPPC3 0 0 103 200 1 1
NR1D1 AACS 0 0 139 197 1 1
NR1D1 KAT2A 0 0 112 165 1 1
NR1D1 CRHR1 0 0 48 159 1 1
NR1D1 CX3CR1 0 0 171 171 1 1
NR1D1 TFAP2E 0 0 0 205 1 1
NR1D1 PER3 0 0 860 924 1 1
NR1D1 LPL 0 0 218 218 1 1
NR1D1 PPARA 0 0 719 246 1 2
NR1D1 ATP6V1D 0 0 95 151 1 1
NR1D1 CEBPD 0 0 122 276 1 1
NR1D1 CYP2E1 0 0 155 160 1 2
NR1D1 RAC3 0 0 0 185 1 2
NR1D1 C1GALT1C1 0 0 47 194 1 1
NR1D1 SLC27A5 0 0 141 173 1 1
NR1D1 POMC 0 0 310 309 1 1
NR1D1 KLF13 0 0 113 170 1 1
NR1D1 FASN 0 0 373 391 1 2
NR1D1 SLC6A11 0 0 82 188 1 1
NR1D1 RASAL3 0 0 0 922 1 1
NR1D1 CTIF 0 0 0 288 1 1
NR1D1 CYP27A1 0 0 193 214 1 1
NR1D1 IL17A 0 0 181 181 1 2
NR1D1 HNF1A 0 0 206 206 1 1
NR1D1 MAP7D2 0 0 0 150 1 1
NR1D1 BCL11A 0 0 73 155 1 1
NR1D1 GRB7 0 0 134 188 1 1
NR1D1 ADIPOQ 0 0 436 436 1 2
NR1D1 BHLHE40 0 0 786 817 1 1
NR1D1 DPF2 0 0 49 150 1 1
NR1D1 NR2E1 0 0 486 255 1 1
NR1D1 C1D 270 0 66 289 1 1
NR1D1 HIST2H3PS2 0 0 360 360 1 1
NR1D1 CDX1 0 0 0 166 1 1
NR1D1 MAPRE3 0 0 64 277 1 1
NR1D1 FAM136A 0 0 91 228 1 1
NR1D1 H2AFZ 0 0 104 163 1 1
NR1D1 CHKA 0 0 184 183 1 1
NR1D1 CPT1B 0 0 270 274 1 1
NR1D1 NR3C1 0 0 503 276 1 1
NR1D1 FLVCR2 0 0 142 158 1 1
NR1D1 INSIG2 0 0 543 543 1 1
NR1D1 PIP5K1A 0 0 119 209 1 1
NR1D1 BORCS8-MEF2B 0 0 0 161 1 1
NR1D1 RGS16 0 0 123 155 1 1
NR1D1 PHC2 0 0 0 164 1 1
NR1D1 TLE4 0 0 0 178 1 1
NR1D1 CSNK1A1 0 0 209 238 1 1
NR1D1 ENTPD4 0 0 73 291 1 1
NR1D1 TBL1X 0 0 159 174 1 1
NR1D1 ELOVL6 0 0 216 232 1 1
NR1D1 RTP4 0 0 82 239 1 1
NR1D1 ARNT 0 0 243 411 1 2
NR1D1 IRS2 0 0 134 276 1 1
NR1D1 NCOA3 0 0 171 209 1 1
NR1D1 PRDM12 0 0 66 151 1 1
NR1D1 RELL1 0 0 82 254 1 1
NR1D1 RSBN1 0 0 0 187 1 1
NR1D1 PDXDC1 0 0 0 194 1 1
NR1D1 RIPK2 0 0 68 161 1 2
NR1D1 RBFOX1 0 0 0 230 1 1
NR1D1 TSHB 0 0 195 195 1 1
NR1D1 YY2 0 0 0 188 1 1
NR1D1 CCNA2 0 0 180 200 1 1
NR1D1 NCOA2 0 0 134 237 1 1
NR1D1 RERE 0 0 294 294 1 1
NR1D1 CYP7A1 0 0 509 519 1 1
NR1D1 GRHL2 0 0 0 162 1 1
NR1D1 ZBTB16 0 0 143 159 1 1
NR1D1 FAM198A 0 0 145 169 1 1
NR1D1 PER2 0 0 928 945 1 1
NR1D1 SRF 0 0 96 190 1 1
NR1D1 ORMDL3 0 0 143 159 1 2
NR1D1 CERS5 0 0 0 216 1 1
NR1D1 SPSB4 270 0 71 292 1 1
NR1D1 GPR161 0 0 74 480 1 1
NR1D1 FAM19A4 0 0 123 159 1 1
NR1D1 ENSG00000173366 0 0 140 157 1 1
NR1D1 DPYSL2 0 0 263 263 1 1
NR1D1 KRT80 0 0 55 298 1 1
NR1D1 NR2F2 0 0 407 252 1 1
NR1D1 KCNB2 0 0 54 264 1 1
NR1D1 GRIN2C 0 0 125 199 1 1
NR1D1 S1PR4 0 0 0 248 1 1
NR1D1 WDR5 0 0 152 160 1 1
NR1D1 FABP3 0 0 206 211 1 1
NR1D1 SKA3 0 0 107 202 1 1
NR1D1 C10orf12 0 0 96 183 1 1
NR1D1 SPA17 0 0 391 390 1 1
NR1D1 ARID5A 0 0 81 302 1 1
NR1D1 JUN 0 0 181 197 1 2
NR1D1 TFEB 0 0 145 168 1 2
NR1D1 OPN4 0 0 517 549 1 1
NR1D1 HSP90AA1 0 0 167 167 1 2
NR1D1 PNPLA2 0 0 256 300 1 2
NR1D1 ZNHIT1 0 0 74 239 1 1
NR1D1 NPAT 0 0 45 151 1 1
NR1D1 FBXW7 0 0 425 426 1 2
NR1D1 SLC9A3 0 0 187 219 1 1
NR1D1 NEUROD1 0 0 180 179 1 1
NR1D1 DEC1 0 0 370 370 1 1
NR1D1 SOX2 0 0 48 170 1 2
NR1D1 CEBPA 0 0 294 404 1 1
NR1D1 ELF2 0 0 0 287 1 1
NR1D1 DNAJA4 0 0 66 254 1 1
NR1D1 ARNTL2 0 0 683 708 1 1
NR1D1 FAM134C 0 0 107 206 1 1
NR1D1 SUV39H1 0 0 143 177 1 1
NR1D1 ACTB 0 0 370 379 1 2
NR1D1 MBLAC1 0 0 0 157 1 1
NR1D1 INS 0 0 469 469 1 2
NR1D1 KCNH3 0 0 0 254 1 1
NR1D1 TLE1 0 0 63 234 1 1
NR1D1 GTSE1 0 0 53 152 1 1
NR1D1 PRDM14 0 0 0 155 1 1
NR1D1 KLF15 0 0 323 350 1 1
NR1D1 MMP9 0 0 181 181 1 2
NR1D1 B2M 0 0 168 167 1 1
NR1D1 SIRT3 0 0 325 341 1 2
NR1D1 CSNK1E 0 0 705 726 1 1
NR1D1 KMT2C 0 0 146 164 1 1
NR1D1 ABCG1 0 0 136 212 1 2
NR1D1 TFAP2D 0 0 0 175 1 1
NR1D1 HSFX2 0 0 0 164 1 1
NR1D1 GABRD 0 0 0 181 1 1
NR1D1 PCK2 0 0 321 338 1 1
NR1D1 BNIP3 0 0 123 180 1 2
NR1D1 SLC32A1 0 0 66 157 1 1
NR1D1 RSBN1L 0 0 0 187 1 1
NR1D1 CDKN1A 0 0 149 172 1 2
NR1D1 NR1D2 280 0 858 756 1 1
NR1D1 SLMO2 0 0 0 186 1 1
NR1D1 GNRH1 0 0 150 172 1 1
NR1D1 INSR 0 0 74 167 1 1
NR1D1 AR 0 0 226 168 1 2
NR1D1 SOX8 0 0 46 163 1 1
NR1D1 PARP1 0 0 427 427 1 2
NR1D1 GDF10 0 0 122 213 1 1
NR1D1 SLC15A1 0 0 116 156 1 1
NR1D1 CARTPT 0 0 151 184 1 1
NR1D1 CIART 0 0 559 596 1 1
NR1D1 PYY 0 0 134 202 1 1
NR1D1 TULP3 0 0 0 154 1 1
NR1D1 FAM212B 0 0 140 272 1 1
NR1D1 ZBTB7B 0 0 0 151 1 1
NR1D1 ESR2 0 0 427 238 1 1
NR1D1 UBAP1 0 0 0 262 1 1
NR1D1 EHHADH 0 0 181 188 1 1
NR1D1 SIRT7 0 0 288 288 1 2
NR1D1 ELOVL3 0 0 341 341 1 1
NR1D1 FOXA3 0 0 107 217 1 1
NR1D1 SOX9 0 0 66 155 1 1
NR1D1 DPF3 0 0 60 159 1 1
NR1D1 CEBPE 0 0 96 258 1 1
NR1D1 ABCG4 0 0 0 191 1 1
NR1D1 GNB1 0 0 96 236 1 1
NR1D1 PDK2 0 0 83 259 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0000981 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific enables ISA
GO:0001227 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific enables IDA
GO:0070888 Molecular Function E-box binding enables IEA
GO:0000978 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding enables IBA
GO:0000978 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding enables IDA
GO:0000978 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding enables IMP
GO:0000977 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding enables IDA
GO:0020037 Molecular Function heme binding enables IDA
GO:0004879 Molecular Function nuclear receptor activity enables IBA
GO:0003707 Molecular Function nuclear steroid receptor activity enables TAS
GO:0005515 Molecular Function protein binding enables IPI
GO:1990837 Molecular Function sequence-specific double-stranded DNA binding enables IDA
GO:0000976 Molecular Function transcription cis-regulatory region binding enables IDA
GO:0001222 Molecular Function transcription corepressor binding enables IDA
GO:0001222 Molecular Function transcription corepressor binding enables IMP
GO:0008270 Molecular Function zinc ion binding enables IEA
GO:0030154 Biological Process cell differentiation involved_in IBA
GO:0071347 Biological Process cellular response to interleukin-1 involved_in ISS
GO:0071222 Biological Process cellular response to lipopolysaccharide involved_in IMP
GO:0071356 Biological Process cellular response to tumor necrosis factor involved_in ISS
GO:0042632 Biological Process cholesterol homeostasis NOT involved_in IDA
GO:0042632 Biological Process cholesterol homeostasis involved_in ISS
GO:0032922 Biological Process circadian regulation of gene expression involved_in ISS
GO:0060086 Biological Process circadian temperature homeostasis involved_in ISS
GO:0005978 Biological Process glycogen biosynthetic process involved_in ISS
GO:0009755 Biological Process hormone-mediated signaling pathway involved_in IBA
GO:0001678 Biological Process intracellular glucose homeostasis involved_in IMP
GO:0030522 Biological Process intracellular receptor signaling pathway involved_in IEA
GO:0045892 Biological Process negative regulation of DNA-templated transcription involved_in IDA
GO:0045892 Biological Process negative regulation of DNA-templated transcription involved_in IMP
GO:0061889 Biological Process negative regulation of astrocyte activation involved_in ISS
GO:0043124 Biological Process negative regulation of canonical NF-kappaB signal transduction involved_in ISS
GO:0120163 Biological Process negative regulation of cold-induced thermogenesis involved_in ISS
GO:0050728 Biological Process negative regulation of inflammatory response involved_in ISS
GO:1903979 Biological Process negative regulation of microglial cell activation involved_in ISS
GO:0150079 Biological Process negative regulation of neuroinflammatory response involved_in ISS
GO:0034144 Biological Process negative regulation of toll-like receptor 4 signaling pathway involved_in IMP
GO:0000122 Biological Process negative regulation of transcription by RNA polymerase II involved_in IBA
GO:0000122 Biological Process negative regulation of transcription by RNA polymerase II acts_upstream_of_or_within IDA
GO:0000122 Biological Process negative regulation of transcription by RNA polymerase II involved_in IDA
GO:0000122 Biological Process negative regulation of transcription by RNA polymerase II involved_in IMP
GO:0045893 Biological Process positive regulation of DNA-templated transcription involved_in ISS
GO:0070859 Biological Process positive regulation of bile acid biosynthetic process involved_in ISS
GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IBA
GO:0010498 Biological Process proteasomal protein catabolic process involved_in ISS
GO:0031648 Biological Process protein destabilization involved_in ISS
GO:0042752 Biological Process regulation of circadian rhythm involved_in ISS
GO:0042749 Biological Process regulation of circadian sleep/wake cycle involved_in ISS
GO:0045598 Biological Process regulation of fat cell differentiation involved_in ISS
GO:0061178 Biological Process regulation of insulin secretion involved in cellular response to glucose stimulus involved_in ISS
GO:0019216 Biological Process regulation of lipid metabolic process involved_in ISS
GO:0061469 Biological Process regulation of type B pancreatic cell proliferation involved_in ISS
GO:0044321 Biological Process response to leptin involved_in IBA
GO:0044321 Biological Process response to leptin involved_in ISS
GO:0043401 Biological Process steroid hormone mediated signaling pathway involved_in IEA
GO:0000785 Cellular Component chromatin part_of IDA
GO:0000785 Cellular Component chromatin part_of ISA
GO:0005737 Cellular Component cytoplasm located_in ISS
GO:0030425 Cellular Component dendrite located_in ISS
GO:0043197 Cellular Component dendritic spine located_in ISS
GO:0016604 Cellular Component nuclear body located_in IDA
GO:0005654 Cellular Component nucleoplasm located_in TAS
GO:0005634 Cellular Component nucleus located_in ISS
Pathways
Name DB ID
NR1D1 (REV-ERBA) represses gene expression Reactome R-HSA-1368071
Metabolism Reactome R-HSA-1430728
Mitochondrial biogenesis Reactome R-HSA-1592230
Organelle biogenesis and maintenance Reactome R-HSA-1852241
PPARA activates gene expression Reactome R-HSA-1989781
Generic Transcription Pathway Reactome R-HSA-212436
Transcriptional activation of mitochondrial biogenesis Reactome R-HSA-2151201
Cellular responses to stress Reactome R-HSA-2262752
Nuclear Receptor transcription pathway Reactome R-HSA-383280
Regulation of lipid metabolism by PPARalpha Reactome R-HSA-400206
Circadian Clock Reactome R-HSA-400253
Metabolism of lipids Reactome R-HSA-556833
RNA Polymerase II Transcription Reactome R-HSA-73857
Gene expression (Transcription) Reactome R-HSA-74160
Cellular responses to stimuli Reactome R-HSA-8953897
Heme signaling Reactome R-HSA-9707616
Circadian rhythm genes (WP3594) WikiPathways WP3594_r117682
Th17 cell differentiation pathway (WP5130) WikiPathways WP5130_r123523
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_021724 5 mRNA None NC_000017 Reference