EDEM1

ER degradation enhancing alpha-mannosidase like protein 1
General Information
Name ER degradation enhancing alpha-mannosidase like protein 1
Alias
  • ER degradation-enhancing alpha-mannosidase-like protein 1
  • ER degradation enhancer, mannosidase alpha-like 1
  • ER degradation-enhancing alpha-mannosidase-like 1
Synonyms KIAA0212 EDEM
Gene_family Mannosidases alpha class 1
organism Homo sapiens
entrez_id 9695
location 3p26.1
transcript_count 7
exon_count 14
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity and misfolded protein binding activity. Involved in positive regulation of retrograde protein transport, ER to cytosol; protein targeting to ER; and proteolysis involved in protein catabolic process. Located in aggresome and endoplasmic reticulum quality control compartment. [provided by Alliance of Genome Resources, Mar 2025]
      Stringdb ER degradation-enhancing alpha-mannosidase-like protein 1; Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2; Belongs to the glycosyl hydrolase 47 family
      nextProt Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    EDEM1 BioGRID XPO7 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID S GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
    EDEM1 BioGRID METTL14 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID APP GeneID BioGRID Affinity Capture-Western
    EDEM1 BioGRID P3H1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID UGGT1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SELENOS GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID DNAJB12 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID DNAJB11 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID UBE2J1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID OS9 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    EDEM1 BioGRID PDIA4 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID HSP90B1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SEL1L GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    EDEM1 BioGRID PPIB GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID CHRNA4 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID CD3D GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID CAPN1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID CANX GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
    EDEM1 BioGRID CALR GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID VPS51 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID AUP1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ATM GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ANXA7 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID AMFR GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ALDH3A2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ZACN GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MS4A15 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SIRT6 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TEX264 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID WAC GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SH3GLB1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID VPS36 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID DERL2 GeneID BioGRID Affinity Capture-MS; Co-fractionation
    EDEM1 BioGRID UBQLN1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID UBQLN2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID USP25 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TBK1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ERLEC1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    EDEM1 BioGRID NAAA GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ATL3 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SAMM50 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID FBXO7 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MTCH1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID BACE1 GeneID BioGRID Affinity Capture-Western
    EDEM1 BioGRID ATP6V0A2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ECPAS GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID LARP1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID VPS39 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID VPS13A GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID FAF2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID UBXN4 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ATG2A GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TAB2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ERP44 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID USP33 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID WDFY3 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MAN1B1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID RNF139 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID WDR6 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ERLIN2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID WDR45 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID FAF1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SEC61B GeneID BioGRID Affinity Capture-MS; Co-fractionation
    EDEM1 BioGRID RRAGA GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ERLIN1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ATG7 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID HYOU1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID UBE4B GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID STUB1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID NAMPT GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID DNM1L GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MFN2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID RB1CC1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TBC1D5 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID EI24 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID UBE4A GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID USP10 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID HERC1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MTMR3 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-localization
    EDEM1 BioGRID BECN1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID PIP4K2B GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID UBXN8 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID RAB7A GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TRIM25 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID WFS1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID VCP GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TSG101 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TSC2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TSC1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TP53 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SEC62 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SUPT5H GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SGTA GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID S100A9 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID S100A8 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID RPN1 GeneID BioGRID Affinity Capture-Western
    EDEM1 BioGRID ROCK1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID RNF5 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID RLN1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID PSMC6 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID DNAJC3 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID PRKAA1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID PIP4K2A GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID PIK3R2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SERPINA1 GeneID BioGRID Affinity Capture-Western
    EDEM1 BioGRID P4HB GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID NPC1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MSH5 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID DNAJB9 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MCL1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID LMAN1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID LAMP2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID LAMP1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID STT3A GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID HSP90AA1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID HSPA8 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID HSPA5 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID HMOX1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID HTT GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID GSK3B GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID GOLGA2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID GNAI3 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MTOR GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID EP300 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID EIF4G1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID DDOST GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID CLTC GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID VMA21 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID STT3B GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID RAB12 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID CDCP2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID UBR1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID PGAM5 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID VTI1A GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID LLCFC1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID NMS GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID OR1M1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID LYZL2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID OMA1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MTDH GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ACBD5 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TMEM259 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID LOXL3 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID LYZL1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SYVN1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID RHBDD1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SESN2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TMUB1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID VMP1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID EDEM3 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID FOXRED2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID PIP4K2C GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID CHMP6 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MUL1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID TMUB2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ATG9A GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MPPE1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ATG3 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID XYLT2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID EPG5 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID VPS18 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID NCEH1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID RPTOR GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID RHBDD2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MCOLN1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID CCDC47 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID UGGT2 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MFN1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID NPLOC4 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID RNF121 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MAP1S GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ANKZF1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ATG2B GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ATG16L1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID STX17 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SGTB GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID DNAJC10 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    EDEM1 BioGRID ZFYVE1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SUFU GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID GET4 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID FBXO6 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID MTM1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID EGFR GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID GALNT6 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SHH GeneID BioGRID Affinity Capture-Western
    EDEM1 BioGRID PHF6 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID CHD9 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID PNISR GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID PSMD14 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID ACSL4 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID LOC8287993 GeneID BioGRID Affinity Capture-Western
    EDEM1 BioGRID ESYT1 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID HLA-B GeneID BioGRID Affinity Capture-Western
    EDEM1 BioGRID MMS19 GeneID BioGRID Affinity Capture-MS
    EDEM1 BioGRID SSR1 GeneID BioGRID Affinity Capture-Western
    EDEM1 BioGRID ASGR1 GeneID BioGRID Affinity Capture-Western
    EDEM1 BioGRID DERL1 GeneID BioGRID Co-fractionation
    EDEM1 BioGRID RHO GeneID BioGRID Affinity Capture-Western
    EDEM1 BioGRID ASGR2 GeneID BioGRID Affinity Capture-Western; Co-localization
    EDEM1 BioGRID ELAVL1 GeneID BioGRID Affinity Capture-RNA
    EDEM1 Protein CANX GeneID HPRD None
    EDEM1 BioGRID BZW1 GeneID BioGRID Affinity Capture-MS
    StringDB
    A B experiments database textmining combined score hadb nhadb
    EDEM1 BECN1 0 0 181 192 1 2
    EDEM1 FRRS1L 0 0 0 177 1 1
    EDEM1 CHST13 0 0 0 189 1 1
    EDEM1 TMX4 0 0 0 234 1 1
    EDEM1 MOGAT2 0 0 81 284 1 1
    EDEM1 SDC1 0 0 120 166 1 1
    EDEM1 ENSG00000259040 0 0 0 256 1 1
    EDEM1 ENSG00000262660 0 0 81 173 1 1
    EDEM1 CLMP 0 0 0 199 1 1
    EDEM1 PRKCSH 0 0 261 395 1 1
    EDEM1 DERL1 270 0 619 770 1 1
    EDEM1 SUFU 168 0 0 167 1 1
    EDEM1 STT3A 0 0 123 376 1 1
    EDEM1 ALG3 0 0 134 428 1 1
    EDEM1 EMC1 0 0 139 504 1 1
    EDEM1 ANKRD45 0 0 0 327 1 1
    EDEM1 PMAIP1 0 0 181 181 1 1
    EDEM1 DNAJC10 270 0 989 993 1 1
    EDEM1 OR6C2 0 0 0 248 1 1
    EDEM1 ATXN3 0 0 218 218 1 1
    EDEM1 ERLIN2 0 0 108 151 1 1
    EDEM1 WARS 0 0 235 319 1 1
    EDEM1 NAAA 274 0 0 274 1 1
    EDEM1 CPOX 0 0 0 150 1 1
    EDEM1 SAR1B 0 0 95 337 1 1
    EDEM1 SEC62 0 0 224 278 1 1
    EDEM1 DAD1 0 0 122 183 1 1
    EDEM1 PSMD2 0 0 154 153 1 1
    EDEM1 MAN2A2 0 0 181 701 1 1
    EDEM1 DNAJB9 0 0 769 797 1 2
    EDEM1 PDIA3 0 0 566 828 1 1
    EDEM1 LMAN2L 0 0 324 392 1 1
    EDEM1 MAN2B1 0 0 180 591 1 1
    EDEM1 GNMT 0 0 0 254 1 1
    EDEM1 TMUB1 0 0 253 327 1 1
    EDEM1 ALG10 0 0 67 242 1 1
    EDEM1 SH3D21 0 0 0 209 1 1
    EDEM1 ANKRD40 0 0 0 183 1 1
    EDEM1 GID8 0 0 0 258 1 1
    EDEM1 HM13 0 0 108 198 1 1
    EDEM1 MLEC 0 0 420 467 1 1
    EDEM1 SLC35B1 0 0 136 154 1 1
    EDEM1 HSPA5 0 0 748 875 1 2
    EDEM1 CNNM4 0 0 0 217 1 1
    EDEM1 PHF23 0 0 0 189 1 1
    EDEM1 TUSC3 0 0 66 277 1 1
    EDEM1 HLA-B 270 0 0 284 1 1
    EDEM1 ERLIN1 0 0 170 258 1 1
    EDEM1 GALNT1 0 0 181 200 1 1
    EDEM1 CASP4 0 0 215 237 1 2
    EDEM1 TTR 0 0 122 198 1 2
    EDEM1 PNISR 218 0 0 218 1 1
    EDEM1 NPLOC4 0 0 466 617 1 1
    EDEM1 NME9 0 0 0 234 1 1
    EDEM1 PDIA4 0 0 561 826 1 1
    EDEM1 DNAJA2 0 0 90 239 1 1
    EDEM1 MNS1 0 0 561 561 1 1
    EDEM1 TG 0 0 307 307 1 1
    EDEM1 NDRG3 0 0 0 202 1 1
    EDEM1 CEBPB 0 0 191 208 1 1
    EDEM1 LRCH4 0 0 218 218 1 1
    EDEM1 NDRG2 0 0 0 151 1 1
    EDEM1 PDILT 0 0 144 318 1 1
    EDEM1 ERO1LB 0 0 391 454 1 1
    EDEM1 TRIB3 0 0 269 319 1 1
    EDEM1 BLZF1 0 0 175 175 1 1
    EDEM1 UFL1 0 0 81 256 1 1
    EDEM1 PLIN3 0 0 150 371 1 1
    EDEM1 MARCH9 0 0 0 160 1 1
    EDEM1 PLA2G6 0 0 0 244 1 1
    EDEM1 PPIC 0 0 96 199 1 1
    EDEM1 BZW1 244 0 0 243 1 1
    EDEM1 OS9 0 0 895 944 1 1
    EDEM1 CASP3 0 0 270 285 1 2
    EDEM1 PDIA6 0 0 427 543 1 1
    EDEM1 NQO1 0 0 135 161 1 1
    EDEM1 TNFRSF10B 0 0 202 221 1 1
    EDEM1 KDELR3 0 0 0 217 1 1
    EDEM1 ATG12 0 0 155 166 1 2
    EDEM1 BHLHA15 0 0 540 540 1 1
    EDEM1 USP48 0 0 0 236 1 1
    EDEM1 CREBRF 0 0 181 181 1 1
    EDEM1 DNAJC1 0 0 211 211 1 1
    EDEM1 TXNDC2 0 0 0 234 1 1
    EDEM1 FAM134B 0 0 193 194 1 1
    EDEM1 FKBP2 0 0 134 151 1 1
    EDEM1 SREBF1 0 0 243 271 1 2
    EDEM1 BAG1 0 0 146 204 1 2
    EDEM1 CAPN7 0 0 88 166 1 1
    EDEM1 CHFR 0 0 0 252 1 1
    EDEM1 CD164 0 0 67 569 1 1
    EDEM1 ATAD2B 0 0 0 264 1 1
    EDEM1 RTCB 0 0 212 223 1 1
    EDEM1 PHF6 218 0 0 227 1 1
    EDEM1 MAN1A2 0 0 321 218 1 1
    EDEM1 NME8 0 0 0 234 1 1
    EDEM1 NAGPA 0 0 161 184 1 1
    EDEM1 FMO3 0 0 0 161 1 1
    EDEM1 SIL1 0 0 381 405 1 1
    EDEM1 SEC24A 0 0 0 166 1 1
    EDEM1 SCARA3 0 0 88 228 1 1
    EDEM1 TXN2 0 0 0 234 1 1
    EDEM1 GABARAP 0 0 71 164 1 2
    EDEM1 ACSL4 246 0 0 275 1 1
    EDEM1 SLC9C2 0 0 0 327 1 1
    EDEM1 DERL3 0 0 785 862 1 1
    EDEM1 PPP1R15B 0 0 168 208 1 1
    EDEM1 ATG7 0 0 261 289 1 2
    EDEM1 USP34 0 0 0 177 1 1
    EDEM1 CNPY2 0 0 103 268 1 1
    EDEM1 BCAP29 0 0 0 217 1 1
    EDEM1 POLI 0 0 0 189 1 1
    EDEM1 TXNDC12 0 0 167 167 1 1
    EDEM1 CTSD 0 0 59 154 1 2
    EDEM1 M6PR 0 0 406 406 1 1
    EDEM1 COA7 0 0 0 165 1 1
    EDEM1 SURF4 0 0 134 511 1 1
    EDEM1 FBXO40 0 0 95 299 1 1
    EDEM1 GALNT13 0 0 194 213 1 1
    EDEM1 PSMD14 246 0 113 304 1 1
    EDEM1 SEC61B 270 0 608 746 1 1
    EDEM1 SEC22B 0 0 107 234 1 1
    EDEM1 SPRED2 0 0 61 153 1 1
    EDEM1 NUCB1 0 0 66 383 1 1
    EDEM1 SEL1L 675 0 985 997 1 1
    EDEM1 GNPTG 0 0 124 188 1 1
    EDEM1 ULK1 0 0 113 206 1 2
    EDEM1 MAP1LC3B 0 0 154 203 1 2
    EDEM1 ERP27 0 0 74 262 1 1
    EDEM1 FOXRED2 0 0 460 519 1 1
    EDEM1 EIF2A 0 0 252 305 1 1
    EDEM1 COQ4 0 0 0 159 1 1
    EDEM1 TRAM2 0 0 113 256 1 1
    EDEM1 UBE2J2 0 0 270 343 1 1
    EDEM1 USP18 0 0 0 236 1 1
    EDEM1 RRBP1 0 0 96 156 1 1
    EDEM1 UFC1 0 0 72 282 1 1
    EDEM1 HERPUD2 0 0 135 597 1 1
    EDEM1 AGPAT4 0 0 86 322 1 1
    EDEM1 XBP1 0 900 769 983 1 2
    EDEM1 RCN1 0 0 0 206 1 1
    EDEM1 KDELR2 0 0 0 242 1 1
    EDEM1 UGGT2 0 0 337 581 1 1
    EDEM1 PDIA5 0 0 247 400 1 1
    EDEM1 PLCD3 0 0 108 219 1 1
    EDEM1 MANF 0 0 314 333 1 1
    EDEM1 PTPN1 0 0 142 182 1 1
    EDEM1 UFM1 0 0 66 197 1 1
    EDEM1 UGGT1 0 0 632 767 1 1
    EDEM1 ATG5 0 0 310 350 1 2
    EDEM1 BACE1 0 0 307 312 1 1
    EDEM1 MAP3K5 0 0 381 381 1 1
    EDEM1 UBQLN2 295 0 218 514 1 2
    EDEM1 ESR1 0 0 138 175 1 1
    EDEM1 TXNDC5 0 0 230 402 1 1
    EDEM1 PPP1CA 0 0 136 207 1 1
    EDEM1 PLIN2 0 0 137 177 1 1
    EDEM1 STT3B 0 0 194 427 1 1
    EDEM1 PPP1R15A 0 0 638 644 1 2
    EDEM1 USP14 0 0 143 336 1 1
    EDEM1 GALNT8 0 0 180 199 1 1
    EDEM1 NSL1 0 0 0 187 1 1
    EDEM1 GLS2 0 0 165 203 1 1
    EDEM1 SFXN2 0 0 210 210 1 1
    EDEM1 TMEM53 0 0 0 300 1 1
    EDEM1 CLPS 0 0 67 270 1 1
    EDEM1 PIK3R2 0 0 398 398 1 1
    EDEM1 RNF185 0 0 210 210 1 1
    EDEM1 KIAA0141 0 0 0 171 1 1
    EDEM1 UBAC2 0 0 162 161 1 1
    EDEM1 UBL7 0 0 0 190 1 1
    EDEM1 SEL1L3 0 0 0 171 1 1
    EDEM1 TNF 0 0 141 171 1 1
    EDEM1 NBR1 0 0 244 243 1 2
    EDEM1 MGAT4C 0 0 150 165 1 1
    EDEM1 NCR3LG1 0 0 0 199 1 1
    EDEM1 APOB 0 0 181 320 1 1
    EDEM1 UVRAG 0 0 124 158 1 2
    EDEM1 SLC25A25 0 0 0 159 1 1
    EDEM1 ATF3 0 0 256 272 1 1
    EDEM1 TUBGCP6 0 0 0 165 1 1
    EDEM1 SEC61A2 0 0 161 436 1 1
    EDEM1 MGAT5B 0 0 155 161 1 1
    EDEM1 TXNIP 0 0 143 180 1 1
    EDEM1 FKBP1C 0 0 174 211 1 1
    EDEM1 PRDX4 0 0 97 192 1 1
    EDEM1 BCAP31 0 0 216 538 1 1
    EDEM1 SDF2L1 0 0 263 329 1 1
    EDEM1 UBE2J1 0 0 469 507 1 1
    EDEM1 DRAM1 0 0 57 201 1 2
    EDEM1 PIGBOS1 0 0 166 165 1 1
    EDEM1 SRP54 0 0 114 154 1 1
    EDEM1 RNFT2 0 0 0 252 1 1
    EDEM1 CD2AP 0 0 0 209 1 1
    EDEM1 ASB11 0 0 141 287 1 1
    EDEM1 COPB1 0 0 51 217 1 1
    EDEM1 RNF170 0 0 231 236 1 1
    EDEM1 SREBF2 0 0 218 230 1 1
    EDEM1 TXNDC11 0 0 413 683 1 1
    EDEM1 ALG12 0 0 118 466 1 1
    EDEM1 TMX3 0 0 0 234 1 1
    EDEM1 HSPA9 0 0 81 155 1 1
    EDEM1 UBL4A 0 0 141 179 1 1
    EDEM1 HMGCR 0 0 141 344 1 1
    EDEM1 CRBN 0 0 166 186 1 1
    EDEM1 ENO4 0 0 0 208 1 1
    EDEM1 MARCH1 0 0 0 160 1 1
    EDEM1 LRP2BP 0 0 0 171 1 1
    EDEM1 FADS2 0 0 74 172 1 1
    EDEM1 USP13 0 0 161 180 1 1
    EDEM1 FAF2 0 0 615 651 1 1
    EDEM1 SLC25A18 0 0 0 345 1 1
    EDEM1 CANX 753 0 909 985 1 2
    EDEM1 TXN 0 0 376 501 1 1
    EDEM1 AGPAT3 0 0 0 189 1 1
    EDEM1 BAK1 0 0 137 208 1 2
    EDEM1 RNASEL 0 0 82 150 1 1
    EDEM1 DNAJB2 0 0 160 197 1 1
    EDEM1 SSR3 0 0 208 246 1 1
    EDEM1 USP7 0 0 0 265 1 1
    EDEM1 UBR1 0 0 154 229 1 1
    EDEM1 CAMK1G 0 0 90 169 1 1
    EDEM1 SLC25A22 0 0 0 345 1 1
    EDEM1 EMC8 0 0 92 218 1 1
    EDEM1 LOC388210 0 0 0 259 1 1
    EDEM1 MGAT5 0 0 134 171 1 1
    EDEM1 EIF2S1 0 0 460 474 1 2
    EDEM1 GLCE 0 0 0 228 1 1
    EDEM1 RAB11A 0 0 93 174 1 1
    EDEM1 ATF6B 0 0 488 551 1 1
    EDEM1 SEC13 0 0 134 193 1 1
    EDEM1 ADIPOR2 0 0 0 152 1 1
    EDEM1 HMOX1 0 0 154 153 1 2
    EDEM1 TP53INP1 0 0 155 173 1 2
    EDEM1 RTN3 0 0 107 230 1 1
    EDEM1 EIF2AK3 0 0 543 553 1 2
    EDEM1 RNF139 0 0 394 527 1 1
    EDEM1 YOD1 0 0 227 244 1 1
    EDEM1 TXNDC9 0 0 0 234 1 1
    EDEM1 COASY 0 0 47 163 1 1
    EDEM1 DNAJB1 0 0 459 483 1 2
    EDEM1 MAN1C1 0 0 392 241 1 1
    EDEM1 DNAJB11 0 0 612 637 1 1
    EDEM1 ATG4C 0 0 87 158 1 2
    EDEM1 VIMP 0 0 334 334 1 1
    EDEM1 SCD 0 0 195 195 1 1
    EDEM1 TM6SF2 0 0 87 179 1 1
    EDEM1 DGAT2 0 0 260 373 1 1
    EDEM1 FBXO2 0 0 156 155 1 1
    EDEM1 SRRM5 0 0 183 183 1 1
    EDEM1 MGAM 0 0 209 214 1 1
    EDEM1 MAFK 0 0 0 250 1 1
    EDEM1 MAFG 0 0 0 250 1 1
    EDEM1 RTN4 0 0 0 173 1 1
    EDEM1 PHF20 0 0 0 303 1 1
    EDEM1 RNF103 0 0 148 166 1 1
    EDEM1 USP25 0 0 0 253 1 1
    EDEM1 USH2A 0 0 260 260 1 1
    EDEM1 GATM 0 0 0 250 1 1
    EDEM1 HSP90AB1 0 0 54 152 1 2
    EDEM1 UBQLN1 0 0 234 436 1 2
    EDEM1 GALNT12 0 0 167 186 1 1
    EDEM1 CLGN 0 0 0 399 1 1
    EDEM1 SSR2 0 0 107 168 1 1
    EDEM1 MARCH10 0 0 0 160 1 1
    EDEM1 ASNS 0 0 264 264 1 1
    EDEM1 GALNT6 130 0 101 203 1 1
    EDEM1 SPATA5L1 0 0 0 264 1 1
    EDEM1 ATF6 0 0 687 728 1 2
    EDEM1 MARCH8 0 0 0 160 1 1
    EDEM1 B3GNT2 0 0 122 158 1 1
    EDEM1 MCFD2 0 0 157 287 1 1
    EDEM1 EMC10 0 0 46 209 1 1
    EDEM1 DNAJB14 0 0 113 163 1 1
    EDEM1 CREB3L4 0 0 391 415 1 1
    EDEM1 SPATA5 0 0 0 264 1 1
    EDEM1 CALR3 0 0 93 176 1 1
    EDEM1 SDF2 0 0 90 178 1 1
    EDEM1 ENSG00000144785 0 0 0 217 1 1
    EDEM1 DIBD1 0 0 150 448 1 1
    EDEM1 CMC2 0 0 0 424 1 1
    EDEM1 DERL2 270 0 949 975 1 1
    EDEM1 MBTPS1 0 0 459 481 1 1
    EDEM1 ATF4 0 0 563 577 1 2
    EDEM1 UBA5 0 0 75 217 1 1
    EDEM1 ST8SIA4 0 0 156 155 1 1
    EDEM1 ERP29 0 0 182 181 1 1
    EDEM1 ECHS1 0 0 73 226 1 1
    EDEM1 AKT1 0 0 171 204 1 2
    EDEM1 MARCH6 0 0 465 654 1 1
    EDEM1 DYSF 0 0 183 197 1 1
    EDEM1 GALNT15 0 0 168 187 1 1
    EDEM1 DNTT 0 0 94 153 1 1
    EDEM1 EIF2AK1 0 0 271 271 1 1
    EDEM1 SLC35B4 0 0 112 377 1 1
    EDEM1 UBXN4 0 0 414 443 1 1
    EDEM1 MANBA 0 0 158 157 1 1
    EDEM1 ALG10B 0 0 66 241 1 1
    EDEM1 HSPA1A 0 0 164 233 1 1
    EDEM1 FAM69B 0 0 184 252 1 1
    EDEM1 SH2D3C 0 0 283 332 1 1
    EDEM1 LONP2 0 0 142 162 1 1
    EDEM1 GLG1 0 0 0 175 1 1
    EDEM1 BCL2L11 0 0 247 246 1 1
    EDEM1 PHF13 0 0 0 189 1 1
    EDEM1 SERPINA1 270 0 838 877 1 2
    EDEM1 SI 0 0 193 198 1 1
    EDEM1 AMFR 0 0 517 623 1 1
    EDEM1 SIGLEC1 0 0 0 256 1 1
    EDEM1 MAN2A1 0 0 610 781 1 1
    EDEM1 JUN 0 0 218 218 1 1
    EDEM1 FRRS1 0 0 45 413 1 1
    EDEM1 RTN1 0 0 0 173 1 1
    EDEM1 CREB3L2 0 0 419 452 1 1
    EDEM1 GALNT16 0 0 163 178 1 1
    EDEM1 TXNL4A 0 0 108 267 1 1
    EDEM1 VCP 0 0 580 768 1 2
    EDEM1 DNAJC3 0 0 714 802 1 1
    EDEM1 DCSTAMP 0 0 56 227 1 1
    EDEM1 SHH 270 0 0 317 1 1
    EDEM1 ERN2 0 0 519 589 1 1
    EDEM1 SULF1 0 0 69 213 1 1
    EDEM1 FCRLA 0 0 67 185 1 1
    EDEM1 EIF2AK2 0 0 194 413 1 2
    EDEM1 CALR 0 0 747 783 1 1
    EDEM1 BIK 0 0 156 155 1 1
    EDEM1 ERLEC1 0 0 759 873 1 1
    EDEM1 TRIM3 0 0 174 173 1 1
    EDEM1 ALG6 0 0 141 284 1 1
    EDEM1 AWAT1 0 0 122 153 1 1
    EDEM1 SEL1L2 0 0 0 436 1 1
    EDEM1 CREB3 0 0 406 469 1 1
    EDEM1 USP40 0 0 0 236 1 1
    EDEM1 HSPA8 0 0 267 372 1 2
    EDEM1 ERP44 0 0 244 396 1 1
    EDEM1 ATG9A 0 0 95 175 1 2
    EDEM1 SETMAR 0 0 185 195 1 1
    EDEM1 MTTP 0 0 123 321 1 1
    EDEM1 B4GALT5 0 0 143 177 1 1
    EDEM1 CD3D 0 0 232 231 1 1
    EDEM1 RCN2 0 0 0 206 1 1
    EDEM1 PTPRC 0 0 74 172 1 1
    EDEM1 UBE2G2 0 0 391 631 1 1
    EDEM1 TMEM129 0 0 283 282 1 1
    EDEM1 RHBDF2 0 0 150 208 1 1
    EDEM1 SEC31A 0 0 0 185 1 1
    EDEM1 GABARAPL1 0 0 194 275 1 2
    EDEM1 ENSG00000269590 0 0 0 522 1 1
    EDEM1 TUBGCP4 0 0 0 197 1 1
    EDEM1 EMC9 0 0 63 207 1 1
    EDEM1 SAR1A 0 0 0 298 1 1
    EDEM1 STX18 0 0 71 170 1 1
    EDEM1 ZACN 203 0 0 203 1 1
    EDEM1 NHS 0 0 163 163 1 1
    EDEM1 PDIA2 0 0 293 618 1 1
    EDEM1 CREB3L1 0 0 335 359 1 1
    EDEM1 OPN4 0 0 0 183 1 1
    EDEM1 UFD1L 0 0 503 638 1 1
    EDEM1 PNPLA2 0 0 57 157 1 1
    EDEM1 HSP90AA1 0 0 341 369 1 2
    EDEM1 DNAJA4 0 0 0 209 1 1
    EDEM1 ESYT1 295 0 0 319 1 1
    EDEM1 SLA2 0 0 0 323 1 1
    EDEM1 EDEM2 0 800 759 822 1 1
    EDEM1 STUB1 0 0 185 197 1 2
    EDEM1 ATG13 0 0 137 176 1 2
    EDEM1 INS 0 0 235 235 1 1
    EDEM1 ACTB 0 0 294 300 1 1
    EDEM1 TUBGCP3 0 0 0 165 1 1
    EDEM1 TRAM1 0 0 0 166 1 1
    EDEM1 DPP7 0 0 0 200 1 1
    EDEM1 RNF5 0 0 464 463 1 1
    EDEM1 SQSTM1 270 0 447 579 1 2
    EDEM1 SARAF 0 0 292 310 1 1
    EDEM1 LRRN1 0 0 231 230 1 1
    EDEM1 ADIPOR1 0 0 0 152 1 1
    EDEM1 SPOPL 0 0 134 205 1 1
    EDEM1 UBQLN3 0 0 0 190 1 1
    EDEM1 CALU 0 0 60 458 1 1
    EDEM1 AUP1 0 0 536 542 1 1
    EDEM1 HCFC1 0 0 99 170 1 1
    EDEM1 SEC23B 0 0 184 691 1 2
    EDEM1 SEC63 0 0 382 431 1 1
    EDEM1 B3GNT3 0 0 123 159 1 1
    EDEM1 UBOX5 0 0 0 158 1 1
    EDEM1 ERO1L 0 0 517 567 1 1
    EDEM1 MAGT1 0 0 47 262 1 1
    EDEM1 CREB3L3 0 0 455 598 1 1
    EDEM1 TXNDC16 0 0 310 450 1 1
    EDEM1 RPL19 0 0 107 170 1 1
    EDEM1 ALB 0 0 147 165 1 1
    EDEM1 MMS19 270 0 0 270 1 1
    EDEM1 CASP8 0 0 125 170 1 2
    EDEM1 SGTA 0 0 119 158 1 1
    EDEM1 USP28 0 0 0 253 1 1
    EDEM1 CASP7 0 0 154 178 1 1
    EDEM1 RAP1GAP2 0 0 91 229 1 1
    EDEM1 PITPNM1 0 0 92 298 1 1
    EDEM1 HERPUD1 0 0 609 761 1 1
    EDEM1 OR2A12 0 0 279 279 1 1
    EDEM1 MARCH2 0 0 0 160 1 1
    EDEM1 HYOU1 0 0 487 595 1 1
    EDEM1 VOPP1 0 0 57 159 1 1
    EDEM1 SEC31B 0 0 0 185 1 1
    EDEM1 MARCH11 0 0 0 160 1 1
    EDEM1 LAX1 0 0 73 212 1 1
    EDEM1 SGK494 0 0 53 350 1 1
    EDEM1 VCPIP1 0 0 164 171 1 1
    EDEM1 COX10 0 0 0 216 1 1
    EDEM1 EMC6 0 0 46 246 1 1
    EDEM1 MARCH4 0 0 72 187 1 1
    EDEM1 RAB6A 0 0 72 163 1 1
    EDEM1 COX6A2 0 0 0 187 1 1
    EDEM1 SEC61G 0 0 108 156 1 1
    EDEM1 GNPTAB 0 0 134 171 1 1
    EDEM1 MARCH3 0 0 0 160 1 1
    EDEM1 USP24 0 0 0 177 1 1
    EDEM1 MAPK8 0 0 193 210 1 2
    EDEM1 UBALD2 0 0 0 252 1 1
    EDEM1 C1GALT1 0 0 112 167 1 1
    EDEM1 CDK5RAP3 0 0 116 461 1 1
    EDEM1 EMC3 0 0 108 267 1 1
    EDEM1 TRAPPC11 0 0 0 207 1 1
    EDEM1 RCN3 0 0 0 206 1 1
    EDEM1 UBQLNL 0 0 0 190 1 1
    EDEM1 MBTPS2 0 0 455 689 1 1
    EDEM1 DIAPH2 0 0 0 211 1 1
    EDEM1 SAA2 0 0 107 162 1 1
    EDEM1 TRPC4AP 0 0 0 215 1 1
    EDEM1 UBE4B 0 0 141 246 1 1
    EDEM1 HSPA4 0 0 391 440 1 1
    EDEM1 GPHN 0 0 0 183 1 1
    EDEM1 SEC23A 0 0 61 486 1 2
    EDEM1 TYR 0 0 504 504 1 1
    EDEM1 TMX1 0 0 76 262 1 1
    EDEM1 PPIB 0 0 144 165 1 1
    EDEM1 PIK3R1 0 0 264 264 1 1
    EDEM1 ENTPD5 0 0 154 153 1 1
    EDEM1 ENDOU 0 0 0 175 1 1
    EDEM1 HSP90B1 0 0 681 703 1 1
    EDEM1 NUCB2 0 0 0 367 1 1
    EDEM1 TRIM55 0 0 0 175 1 1
    EDEM1 ITPR1 0 0 216 216 1 2
    EDEM1 CASP9 0 0 161 178 1 1
    EDEM1 C1GALT1C1 0 0 112 167 1 1
    EDEM1 MAN2B2 0 0 0 645 1 1
    EDEM1 CYCS 0 0 164 163 1 1
    EDEM1 HGSNAT 0 0 91 282 1 1
    EDEM1 WBP1 0 0 81 178 1 1
    EDEM1 PTPN3 0 0 57 174 1 1
    EDEM1 PHF20L1 0 0 0 189 1 1
    EDEM1 FASN 0 0 181 232 1 1
    EDEM1 GLS 0 0 175 212 1 1
    EDEM1 TRAF2 0 0 228 276 1 1
    EDEM1 TMBIM6 0 0 377 386 1 1
    EDEM1 P4HB 128 0 595 851 1 2
    EDEM1 UBXN7 0 0 95 261 1 1
    EDEM1 DGAT1 0 0 59 158 1 1
    EDEM1 WFS1 0 0 246 329 1 1
    EDEM1 ARL8B 0 0 212 241 1 1
    EDEM1 MAN1A1 0 0 390 258 1 1
    EDEM1 RASAL1 0 0 57 156 1 1
    EDEM1 RB1CC1 0 0 134 163 1 2
    EDEM1 MARCH7 0 0 0 160 1 1
    EDEM1 GET4 0 0 150 172 1 1
    EDEM1 FKBP11 0 0 208 260 1 1
    EDEM1 FKBP7 0 0 194 194 1 1
    EDEM1 SEC24C 0 0 145 328 1 1
    EDEM1 FURIN 0 0 90 171 1 1
    EDEM1 FAM8A1 0 0 218 218 1 1
    EDEM1 ASGR1 270 0 0 270 1 1
    EDEM1 SSR1 270 0 74 307 1 1
    EDEM1 PNLIPRP1 0 0 0 175 1 1
    EDEM1 RTN2 0 0 0 173 1 1
    EDEM1 ENGASE 0 0 242 241 1 1
    EDEM1 SUCO 0 0 82 232 1 1
    EDEM1 KDELR1 0 0 218 381 1 1
    EDEM1 PRSS57 0 0 284 289 1 1
    EDEM1 ZNF697 0 0 161 161 1 1
    EDEM1 GOLPH3 0 0 272 304 1 1
    EDEM1 SEC16A 0 0 0 200 1 2
    EDEM1 GALNT11 0 0 218 236 1 1
    EDEM1 HSPBP1 0 0 101 164 1 1
    EDEM1 DDIT3 0 0 636 658 1 2
    EDEM1 CAPNS2 0 0 140 160 1 1
    EDEM1 CTSA 0 0 0 231 1 1
    EDEM1 PNLIP 0 0 81 209 1 1
    EDEM1 SUMF1 0 0 218 235 1 1
    EDEM1 DNAJA1 0 0 127 337 1 1
    EDEM1 TXNL1 0 0 72 221 1 1
    EDEM1 INSIG1 0 0 261 261 1 1
    EDEM1 CFTR 0 0 340 354 1 1
    EDEM1 COPB2 0 0 66 248 1 1
    EDEM1 CNNM2 0 0 0 217 1 1
    EDEM1 FBXO6 0 0 324 323 1 1
    EDEM1 MOGAT1 0 0 0 252 1 1
    EDEM1 PPP1CC 0 0 107 187 1 1
    EDEM1 RPN1 0 0 215 350 1 1
    EDEM1 ERN1 0 0 760 800 1 2
    EDEM1 TXNDC8 0 0 0 234 1 1
    EDEM1 SERPINH1 0 0 236 236 1 1
    EDEM1 EIF2AK4 0 0 288 304 1 1
    EDEM1 TMPPE 0 0 123 492 1 1
    EDEM1 CPVL 0 0 103 280 1 1
    EDEM1 MTCH1 295 0 0 295 1 1
    EDEM1 HUWE1 0 0 0 150 1 1
    EDEM1 FMO6P 0 0 0 161 1 1
    EDEM1 CHST11 0 0 67 210 1 1
    EDEM1 AGR2 0 0 175 175 1 1
    EDEM1 UBE4A 0 0 170 271 1 1
    EDEM1 SFTPC 0 0 212 212 1 1
    EDEM1 GANAB 0 0 342 385 1 1
    EDEM1 RNF145 0 0 0 252 1 1
    EDEM1 RHO 270 0 142 398 1 1
    EDEM1 PSAT1 0 0 88 150 1 1
    EDEM1 GOLT1B 0 0 112 186 1 1
    EDEM1 POLH 0 0 0 189 1 1
    EDEM1 RNFT1 0 0 0 252 1 1
    EDEM1 BAG3 0 0 137 277 1 2
    EDEM1 SEC16B 0 0 0 183 1 2
    EDEM1 EDEM3 0 800 800 829 1 1
    EDEM1 SETD5 0 0 0 189 1 1
    EDEM1 ALG9 0 0 150 593 1 1
    EDEM1 SEC11C 0 0 67 228 1 1
    EDEM1 GOLT1A 0 0 122 259 1 1
    EDEM1 DDOST 0 0 113 416 1 1
    EDEM1 NDRG1 0 0 0 202 1 1
    EDEM1 USP41 0 0 0 236 1 1
    EDEM1 UBE2G1 0 0 162 249 1 1
    EDEM1 SEC24B 0 0 67 189 1 1
    EDEM1 SULF2 0 0 81 223 1 1
    EDEM1 PIK3C3 0 0 124 162 1 2
    EDEM1 CTRL 0 0 95 293 1 1
    EDEM1 NALCN 0 0 0 188 1 1
    EDEM1 PADI1 0 0 580 580 1 1
    EDEM1 SYVN1 0 0 664 844 1 1
    EDEM1 CRELD2 0 0 205 302 1 1
    EDEM1 CYR61 0 0 0 152 1 1
    EDEM1 SEC61A1 0 0 610 737 1 1
    EDEM1 MAN2C1 0 0 66 478 1 1
    EDEM1 MAN1B1 0 0 751 322 1 1
    EDEM1 SEC24D 0 0 171 381 1 1
    EDEM1 GNE 0 0 77 156 1 1
    EDEM1 ANXA5 0 0 149 184 1 1
    EDEM1 LMAN1 0 0 391 604 1 1
    EDEM1 RAB40B 0 0 134 152 1 1
    EDEM1 DIAPH1 0 0 49 394 1 1
    EDEM1 NGLY1 0 0 267 467 1 1
    EDEM1 SCAP 0 0 171 189 1 1
    EDEM1 SERPINI1 0 0 96 186 1 1
    EDEM1 ENSG00000258472 0 0 0 342 1 1
    EDEM1 RER1 0 0 245 619 1 1
    EDEM1 ATF5 0 0 242 258 1 1
    EDEM1 DPAGT1 0 0 134 154 1 1
    EDEM1 IGJ 0 0 150 205 1 1
    EDEM1 PRCP 0 0 60 472 1 1
    EDEM1 NDRG4 0 0 0 151 1 1
    EDEM1 HSPA1L 0 0 124 197 1 1
    EDEM1 MPPE1 130 0 0 184 1 1
    EDEM1 APOA4 0 0 0 294 1 1
    EDEM1 NSF 0 0 84 161 1 1
    EDEM1 LMAN2 0 0 315 403 1 1
    EDEM1 SERP1 0 0 519 546 1 1
    EDEM1 HIST2H2AC 0 0 445 445 1 1
    EDEM1 SH3KBP1 0 0 0 461 1 1
    EDEM1 SLC25A10 0 0 81 173 1 1
    EDEM1 USP9X 0 0 0 177 1 1
    EDEM1 UBQLN4 0 0 0 293 1 2
    EDEM1 KLHL26 0 0 193 193 1 1
    EDEM1 LMAN1L 0 0 0 158 1 1
    EDEM1 GAPDH 0 0 294 294 1 2
    EDEM1 USP47 0 0 0 177 1 1
    EDEM1 MOGS 0 0 562 638 1 1
    EDEM1 RD3 0 0 457 457 1 1
    EDEM1 GABARAPL2 0 0 182 264 1 2
    EDEM1 ASGR2 270 0 0 270 1 1
    EDEM1 BCL2L1 0 0 143 161 1 2
    EDEM1 MGAT2 0 0 123 195 1 1
    EDEM1 KMT2E 0 0 0 189 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005509 Molecular Function calcium ion binding enables IEA
    GO:0004571 Molecular Function mannosyl-oligosaccharide 1,2-alpha-mannosidase activity NOT enables IDA
    GO:0004571 Molecular Function mannosyl-oligosaccharide 1,2-alpha-mannosidase activity enables IMP
    GO:0004571 Molecular Function mannosyl-oligosaccharide 1,2-alpha-mannosidase activity enables TAS
    GO:0051787 Molecular Function misfolded protein binding enables IDA
    GO:0051787 Molecular Function misfolded protein binding enables IMP
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0036503 Biological Process ERAD pathway involved_in IMP
    GO:0036503 Biological Process ERAD pathway involved_in ISS
    GO:0005975 Biological Process carbohydrate metabolic process involved_in IEA
    GO:1904380 Biological Process endoplasmic reticulum mannose trimming involved_in IEA
    GO:0006058 Biological Process mannoprotein catabolic process involved_in IMP
    GO:1904154 Biological Process positive regulation of retrograde protein transport, ER to cytosol involved_in IGI
    GO:1904154 Biological Process positive regulation of retrograde protein transport, ER to cytosol involved_in IMP
    GO:0045047 Biological Process protein targeting to ER involved_in IMP
    GO:0006986 Biological Process response to unfolded protein involved_in IEA
    GO:0006511 Biological Process ubiquitin-dependent protein catabolic process involved_in IMP
    GO:0016235 Cellular Component aggresome located_in IDA
    GO:0005783 Cellular Component endoplasmic reticulum located_in IDA
    GO:0005783 Cellular Component endoplasmic reticulum located_in IMP
    GO:0005789 Cellular Component endoplasmic reticulum membrane located_in ISS
    GO:0044322 Cellular Component endoplasmic reticulum quality control compartment located_in IDA
    GO:0044322 Cellular Component endoplasmic reticulum quality control compartment located_in TAS
    Pathways
    Name DB ID
    Cellular responses to stress Reactome R-HSA-2262752
    XBP1(S) activates chaperone genes Reactome R-HSA-381038
    IRE1alpha activates chaperones Reactome R-HSA-381070
    Unfolded Protein Response (UPR) Reactome R-HSA-381119
    Metabolism of proteins Reactome R-HSA-392499
    Asparagine N-linked glycosylation Reactome R-HSA-446203
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle Reactome R-HSA-532668
    Post-translational protein modification Reactome R-HSA-597592
    Cellular responses to stimuli Reactome R-HSA-8953897
    ER Quality Control Compartment (ERQC) Reactome R-HSA-901032
    Calnexin/calreticulin cycle Reactome R-HSA-901042
    Photodynamic therapy-induced unfolded protein response (WP3613) WikiPathways WP3613_r106539
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XR_007095771 1 miscRNA transcript variant X2 NC_000003 Reference
    XM_011534272 3 mRNA transcript variant X4 NC_000003 Reference
    NM_014674 3 mRNA None NC_000003 Reference
    XM_047449264 1 mRNA transcript variant X1 NC_000003 Reference
    XM_047449265 1 mRNA transcript variant X3 NC_000003 Reference
    XM_047449266 1 mRNA transcript variant X5 NC_000003 Reference
    XM_047449267 1 mRNA transcript variant X6 NC_000003 Reference