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TECPR2

tectonin beta-propeller repeat containing 2
General Information
Name tectonin beta-propeller repeat containing 2
Alias
  • tectonin beta-propeller repeat-containing protein 2
Gene_family
organism Homo sapiens
entrez_id 9895
location 14q32.33
transcript_count 2
exon_count 20
Cross References
Location
by NCBI GRCh38.p14
Summary
    Entrez The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family, and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy, as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR), which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
    Stringdb Tectonin beta-propeller repeat-containing protein 2; Probably plays a role as positive regulator of autophagy; Belongs to the WD repeat KIAA0329 family
    nextProt Probably plays a role as positive regulator of autophagy.
Interactions
NCBI
A A.Source B B.DB B.Source Description PubMed
TECPR2 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
TECPR2 BioGRID YTHDC1 GeneID BioGRID Affinity Capture-RNA
TECPR2 BioGRID VPS33A GeneID BioGRID Affinity Capture-MS
TECPR2 BioGRID VPS16 GeneID BioGRID Affinity Capture-MS
TECPR2 BioGRID VPS18 GeneID BioGRID Affinity Capture-MS
TECPR2 BioGRID VPS41 GeneID BioGRID Affinity Capture-MS
TECPR2 BioGRID NUDCD3 GeneID BioGRID Affinity Capture-MS
TECPR2 BioGRID PPM1A GeneID BioGRID Affinity Capture-MS
TECPR2 BioGRID HSPA8 GeneID BioGRID Affinity Capture-MS
TECPR2 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
TECPR2 BioGRID RAB5A GeneID BioGRID Proximity Label-MS
TECPR2 BioGRID CCR2 GeneID BioGRID Two-hybrid
TECPR2 BioGRID VIRMA GeneID BioGRID Affinity Capture-RNA
TECPR2 BioGRID HNRNPL GeneID BioGRID Affinity Capture-RNA
TECPR2 BioGRID DNAJB5 GeneID BioGRID Affinity Capture-MS
TECPR2 BioGRID GABARAP GeneID BioGRID Affinity Capture-MS
StringDB
A B experiments database textmining combined score hadb nhadb
TECPR2 ABCG2 0 0 0 182 1 1
TECPR2 TNFRSF11B 0 0 46 194 1 1
TECPR2 PLP1 0 0 261 261 1 1
TECPR2 MAP1A 0 0 218 244 1 2
TECPR2 DVL2 0 0 108 183 1 2
TECPR2 EPG5 0 0 452 672 1 2
TECPR2 DDHD2 0 0 507 507 1 1
TECPR2 EDN3 0 0 0 157 1 1
TECPR2 SNX14 0 0 321 328 1 1
TECPR2 AQP3 0 0 75 233 1 1
TECPR2 RRM2B 0 0 103 565 1 1
TECPR2 HTT 0 0 145 195 1 2
TECPR2 KANK1 0 0 150 241 1 1
TECPR2 TP53INP2 0 0 202 286 1 2
TECPR2 KCNQ4 0 0 124 362 1 1
TECPR2 SPG11 0 0 509 509 1 1
TECPR2 ANKFY1 0 0 71 168 1 1
TECPR2 AP3D1 0 0 0 166 1 1
TECPR2 KIF5C 0 0 0 194 1 1
TECPR2 ATG2A 0 0 341 400 1 2
TECPR2 CD300C 0 0 269 269 1 1
TECPR2 NT5C2 0 0 248 299 1 1
TECPR2 ABCG5 0 0 0 182 1 1
TECPR2 OR11A1 0 0 0 206 1 1
TECPR2 VPS41 675 0 0 687 1 1
TECPR2 MKKS 0 0 0 181 1 1
TECPR2 EDN2 0 0 0 183 1 1
TECPR2 KLC2 0 0 181 204 1 1
TECPR2 REEP2 0 0 517 648 1 1
TECPR2 TECPR1 0 0 501 283 1 1
TECPR2 ABHD2 0 0 172 171 1 1
TECPR2 FLRT1 0 0 204 327 1 1
TECPR2 DNAJB2 0 0 155 230 1 1
TECPR2 BRD4 0 0 99 151 1 2
TECPR2 PCYT2 0 0 181 186 1 1
TECPR2 KIAA0196 0 0 427 426 1 1
TECPR2 HS6ST3 0 0 81 160 1 1
TECPR2 MTCH1 0 0 203 203 1 1
TECPR2 TMEM19 0 0 0 195 1 1
TECPR2 WIPI2 0 0 261 261 1 2
TECPR2 PNPLA6 0 0 418 422 1 1
TECPR2 WDR45B 0 0 82 248 1 1
TECPR2 ALDH18A1 0 0 243 717 1 1
TECPR2 ABCA2 0 0 0 153 1 1
TECPR2 WDR64 0 0 370 370 1 1
TECPR2 CYP7B1 0 0 310 315 1 1
TECPR2 AP4M1 0 0 455 455 1 1
TECPR2 AP4S1 0 0 520 548 1 1
TECPR2 SLC16A2 0 0 325 325 1 1
TECPR2 ZFYVE26 0 0 563 675 1 1
TECPR2 FA2H 0 0 406 417 1 1
TECPR2 PEX1 0 0 0 254 1 1
TECPR2 B4GALNT1 0 0 456 456 1 1
TECPR2 RAB3GAP1 0 0 53 153 1 1
TECPR2 RTN2 0 0 466 469 1 1
TECPR2 SEC24C 0 0 207 218 1 1
TECPR2 WDFY3 0 0 194 317 1 2
TECPR2 UVRAG 0 0 188 194 1 2
TECPR2 TRAPPC2L 0 0 307 312 1 1
TECPR2 MTMR2 0 0 117 227 1 1
TECPR2 RNF41 0 0 135 189 1 1
TECPR2 WDR45 0 0 505 639 1 2
TECPR2 RB1CC1 0 0 262 280 1 2
TECPR2 VGLL3 0 0 60 203 1 1
TECPR2 GDAP1 0 0 122 194 1 1
TECPR2 SEC16A 0 0 387 386 1 2
TECPR2 GOLPH3 0 0 271 271 1 1
TECPR2 PGAP1 0 0 323 323 1 1
TECPR2 ERAP2 0 0 170 169 1 1
TECPR2 TCP1 0 0 0 181 1 1
TECPR2 ATG4B 0 0 113 316 1 2
TECPR2 ZMPSTE24 0 0 0 188 1 1
TECPR2 RAB7A 0 0 193 198 1 2
TECPR2 BCAP31 0 0 143 335 1 1
TECPR2 FARS2 0 0 167 622 1 1
TECPR2 SPG21 0 0 504 504 1 1
TECPR2 GBAS 0 0 141 235 1 1
TECPR2 CRYBB3 0 0 0 293 1 1
TECPR2 ZFC3H1 0 0 0 195 1 1
TECPR2 IBA57 0 0 405 663 1 1
TECPR2 RPA3 0 0 0 254 1 1
TECPR2 RNF213 0 0 138 597 1 1
TECPR2 CCZ1B 0 0 61 288 1 1
TECPR2 MAP1LC3B2 0 0 0 163 1 1
TECPR2 VPS37A 0 0 469 478 1 1
TECPR2 PEX6 0 0 0 219 1 1
TECPR2 LRSAM1 0 0 183 322 1 2
TECPR2 FIG4 0 0 112 205 1 1
TECPR2 CALB2 0 0 0 303 1 1
TECPR2 BSCL2 0 0 392 392 1 1
TECPR2 KIF1A 0 0 385 440 1 1
TECPR2 NIPA1 0 0 418 422 1 1
TECPR2 PELI2 0 0 194 371 1 1
TECPR2 ABCG8 0 0 0 182 1 1
TECPR2 CDAN1 0 0 0 150 1 1
TECPR2 SWAP70 0 0 0 189 1 1
TECPR2 MIA2 0 0 184 189 1 1
TECPR2 GABARAPL2 116 0 519 614 1 2
TECPR2 ASMTL 0 0 241 240 1 1
TECPR2 ATG14 0 0 204 253 1 2
TECPR2 ZFR 0 0 321 321 1 1
TECPR2 LARS2 0 0 207 207 1 1
TECPR2 VMP1 0 0 218 296 1 2
TECPR2 FYCO1 0 0 235 262 1 2
TECPR2 TRAPPC12 0 0 294 678 1 1
TECPR2 CAPN1 0 0 126 156 1 2
TECPR2 CLPP 0 0 181 181 1 1
TECPR2 ALS2 0 0 142 293 1 1
TECPR2 USO1 0 0 251 250 1 1
TECPR2 SBF2 0 0 141 250 1 1
TECPR2 KLC3 0 0 169 169 1 1
TECPR2 INPP5B 0 0 143 194 1 1
TECPR2 BNIP3L 0 0 150 173 1 2
TECPR2 TRAPPC1 0 0 248 269 1 1
TECPR2 RAB7B 0 0 203 208 1 1
TECPR2 KBTBD6 0 0 193 248 1 1
TECPR2 TRAPPC3L 0 0 0 207 1 1
TECPR2 MFN2 0 0 241 718 1 2
TECPR2 PEX13 0 0 0 219 1 1
TECPR2 TMEM200C 0 0 218 338 1 1
TECPR2 MAP1LC3A 0 0 150 291 1 2
TECPR2 SEC24B 0 0 381 381 1 1
TECPR2 MTPAP 0 0 163 163 1 1
TECPR2 PEX11A 0 0 0 210 1 1
TECPR2 LIN28B 0 0 95 417 1 1
TECPR2 MMGT1 0 0 244 243 1 1
TECPR2 SEC13 0 0 218 218 1 1
TECPR2 ATG2B 0 0 181 211 1 2
TECPR2 KIAA1429 270 0 0 270 1 1
TECPR2 CCT5 0 0 377 384 1 1
TECPR2 CTAGE5 0 0 181 199 1 1
TECPR2 SMPD3 0 0 92 440 1 1
TECPR2 EDN1 0 0 0 220 1 1
TECPR2 CCZ1 0 0 61 288 1 1
TECPR2 RINT1 0 0 123 216 1 1
TECPR2 AP5B1 0 0 90 167 1 1
TECPR2 ATG3 0 0 161 356 1 2
TECPR2 TNFRSF1A 0 0 0 190 1 1
TECPR2 FIBIN 0 0 0 171 1 1
TECPR2 FARSA 0 0 0 292 1 1
TECPR2 ATL1 0 0 217 217 1 1
TECPR2 KBTBD7 0 0 107 260 1 1
TECPR2 PIK3C3 0 0 226 225 1 2
TECPR2 ARL6IP1 0 0 324 373 1 1
TECPR2 DMRT2 0 0 164 163 1 1
TECPR2 GAD1 0 0 150 207 1 1
TECPR2 TNFSF11 0 0 0 223 1 2
TECPR2 SEC24D 0 0 799 799 1 1
TECPR2 CCDC43 0 0 310 309 1 1
TECPR2 KIF5B 0 0 0 194 1 1
TECPR2 DBNDD2 0 0 0 155 1 1
TECPR2 ENSG00000250232 0 0 423 580 1 1
TECPR2 TRAPPC8 0 0 297 603 1 1
TECPR2 ENTPD1 0 0 134 167 1 1
TECPR2 ATG4C 0 0 81 276 1 2
TECPR2 PEX2 0 0 47 195 1 1
TECPR2 OPA3 0 0 315 315 1 1
TECPR2 USP8 0 0 205 239 1 1
TECPR2 KIF1C 0 0 290 403 1 1
TECPR2 MTERF4 0 0 204 204 1 1
TECPR2 PEX7 0 0 0 190 1 1
TECPR2 ATG9A 0 0 112 259 1 2
TECPR2 RAB24 0 0 180 185 1 2
TECPR2 AP5Z1 0 0 507 507 1 1
TECPR2 PI4K2A 0 0 181 182 1 1
TECPR2 PEX14 0 0 0 190 1 2
TECPR2 STX18 0 0 194 194 1 1
TECPR2 CSF1 0 0 0 290 1 1
TECPR2 RRM2 0 0 0 386 1 1
TECPR2 VPS16 639 0 53 674 1 1
TECPR2 TRAPPC4 0 0 181 602 1 1
TECPR2 GABARAPL1 55 0 387 473 1 2
TECPR2 ABCG4 0 0 0 199 1 1
TECPR2 SEC31A 0 0 157 178 1 1
TECPR2 ATG16L1 0 0 165 383 1 2
TECPR2 WDR48 0 0 263 404 1 1
TECPR2 ZFP1 0 0 157 156 1 1
TECPR2 RAB1A 0 0 256 256 1 1
TECPR2 CYP2U1 0 0 468 468 1 1
TECPR2 SH3TC2 0 0 150 253 1 1
TECPR2 SLC19A3 0 0 294 294 1 1
TECPR2 TBC1D9 0 0 0 152 1 1
TECPR2 PLEKHM1 0 0 322 365 1 1
TECPR2 LNX1 0 0 0 166 1 1
TECPR2 ATG101 0 0 161 161 1 2
TECPR2 PLA2G6 0 0 241 320 1 1
TECPR2 SPG20 0 0 371 388 1 1
TECPR2 KIF5A 0 0 372 472 1 1
TECPR2 ATG4D 0 0 218 384 1 2
TECPR2 TMTC1 0 0 142 337 1 1
TECPR2 HNRNPL 270 0 0 270 1 1
TECPR2 MARS2 0 0 360 360 1 1
TECPR2 ABCG1 0 0 0 182 1 2
TECPR2 SACS 0 0 157 156 1 1
TECPR2 SQSTM1 0 0 261 261 1 2
TECPR2 ATG12 0 0 209 292 1 2
TECPR2 ATG13 0 0 234 234 1 2
TECPR2 DNAJB5 145 0 0 151 1 1
TECPR2 ZWILCH 0 0 0 206 1 1
TECPR2 SPG7 0 0 419 431 1 1
TECPR2 SLC33A1 0 0 459 459 1 1
TECPR2 ULK2 0 0 182 181 1 2
TECPR2 ERLIN2 0 0 459 552 1 1
TECPR2 ZFYVE27 0 0 470 609 1 1
TECPR2 ELOVL4 0 0 124 258 1 1
TECPR2 PEX3 0 0 46 262 1 2
TECPR2 ARSI 0 0 392 418 1 1
TECPR2 STXBP1 0 0 167 173 1 1
TECPR2 ZNF781 0 0 323 323 1 1
TECPR2 ANXA1 0 0 66 382 1 1
TECPR2 PEX16 0 0 0 238 1 1
TECPR2 SDC1 0 0 0 299 1 1
TECPR2 SAAL1 0 0 0 206 1 1
TECPR2 BECN1 0 0 180 190 1 2
TECPR2 MYO16 0 0 205 205 1 1
TECPR2 TFG 0 0 303 412 1 1
TECPR2 TEX264 0 0 162 177 1 1
TECPR2 CALB1 0 0 82 370 1 1
TECPR2 TRAPPC2 0 0 234 251 1 1
TECPR2 ENSG00000258941 0 0 205 223 1 1
TECPR2 NCOA4 0 0 88 180 1 2
TECPR2 C19orf12 0 0 459 473 1 1
TECPR2 MON1A 0 0 66 220 1 1
TECPR2 VCP 0 0 112 173 1 2
TECPR2 PELI3 0 0 0 215 1 1
TECPR2 TBC1D2B 0 0 90 262 1 1
TECPR2 ERLIN1 0 0 294 662 1 1
TECPR2 GPX2 0 0 81 239 1 1
TECPR2 C18orf8 0 0 0 309 1 1
TECPR2 RASD1 0 0 108 335 1 1
TECPR2 MON1B 0 0 96 233 1 1
TECPR2 SLC4A11 0 0 156 286 1 1
TECPR2 DTNBP1 0 0 0 295 1 1
TECPR2 FUNDC1 0 0 167 177 1 2
TECPR2 TBC1D25 0 0 234 328 1 1
TECPR2 CHST3 0 0 157 328 1 1
TECPR2 MFN1 0 0 0 432 1 2
TECPR2 PHF23 0 0 81 162 1 1
TECPR2 ULK1 0 0 212 216 1 2
TECPR2 DST 0 0 108 278 1 2
TECPR2 REEP1 0 0 391 434 1 1
TECPR2 FNIP1 0 0 54 150 1 1
TECPR2 TBC1D8B 0 0 0 151 1 1
TECPR2 GPR56 0 0 108 239 1 1
TECPR2 HS1BP3 0 0 108 187 1 2
TECPR2 ATG10 0 0 144 177 1 2
TECPR2 TRAPPC11 0 0 267 333 1 1
TECPR2 VPS18 639 0 45 666 1 1
TECPR2 GJC2 0 0 400 413 1 1
TECPR2 WDFY4 0 0 0 188 1 1
TECPR2 BATF3 0 0 74 216 1 1
TECPR2 MAP1LC3B 59 0 433 515 1 2
TECPR2 SDC2 0 0 0 227 1 1
TECPR2 FAM20C 0 0 134 330 1 1
TECPR2 FBXO7 0 0 217 217 1 1
TECPR2 SYP 0 0 74 156 1 1
TECPR2 TBC1D9B 0 0 95 300 1 1
TECPR2 CRH 0 0 0 200 1 1
TECPR2 NIPSNAP1 0 0 150 238 1 1
TECPR2 ATG5 0 0 453 478 1 2
TECPR2 VAMP1 0 0 290 309 1 1
TECPR2 TBC1D5 0 0 243 308 1 2
TECPR2 PEX11B 0 0 0 210 1 1
TECPR2 CEP250 0 0 171 302 1 1
TECPR2 C12orf65 0 0 556 656 1 1
TECPR2 TRAPPC6A 0 0 283 309 1 1
TECPR2 LIF 0 0 0 303 1 2
TECPR2 AP4E1 0 0 492 516 1 1
TECPR2 PELI1 0 0 0 226 1 1
TECPR2 BLOC1S2 0 0 0 303 1 1
TECPR2 TMEM59 0 0 140 184 1 1
TECPR2 UCMA 0 0 265 377 1 1
TECPR2 PEX11G 0 0 0 210 1 1
TECPR2 GADD45B 0 0 0 163 1 1
TECPR2 AFG3L2 0 0 270 342 1 1
TECPR2 IL13RA2 0 0 0 227 1 1
TECPR2 OPTN 0 0 184 190 1 2
TECPR2 ATG4A 0 0 125 342 1 2
TECPR2 TRAPPC5 0 0 203 613 1 1
TECPR2 HPS3 0 0 0 173 1 1
TECPR2 FAM20A 0 0 0 175 1 1
TECPR2 GBA2 0 0 505 529 1 1
TECPR2 PEX12 0 0 0 191 1 1
TECPR2 AMBRA1 0 0 211 346 1 2
TECPR2 FAM134B 0 0 203 286 1 1
TECPR2 FDXACB1 0 0 0 518 1 1
TECPR2 BBS10 0 0 145 377 1 1
TECPR2 TYROBP 0 0 75 276 1 1
TECPR2 AMPD2 0 0 337 382 1 1
TECPR2 KDM5C 0 0 155 162 1 1
TECPR2 GABARAP 117 0 220 382 1 2
TECPR2 TRAPPC3 0 0 254 383 1 1
TECPR2 AGPS 0 0 0 217 1 1
TECPR2 AP4B1 0 0 506 516 1 1
TECPR2 PANK2 0 0 95 162 1 1
TECPR2 WIPI1 0 0 321 321 1 2
TECPR2 DDHD1 0 0 507 507 1 1
TECPR2 DNM2 0 0 92 171 1 1
TECPR2 SPAST 0 0 342 364 1 1
TECPR2 ATG7 0 0 209 215 1 2
TECPR2 MAP1LC3C 131 0 674 742 1 2
TECPR2 ATG16L2 0 0 99 335 1 2
TECPR2 SDC3 0 0 0 227 1 1
TECPR2 DAPK2 0 0 135 153 1 2
TECPR2 NAV2 0 0 155 271 1 1
TECPR2 PIK3R5 0 0 180 404 1 1
TECPR2 TBC1D8 0 0 0 151 1 1
TECPR2 FMN1 0 0 0 163 1 1
TECPR2 TRAPPC2P1 0 0 219 236 1 1
TECPR2 WAC 0 0 167 210 1 1
TECPR2 PREB 0 0 293 293 1 1
TECPR2 NEFL 0 0 113 202 1 1
TECPR2 FOXN4 0 0 136 158 1 1
TECPR2 BCAP29 0 0 0 207 1 1
TECPR2 RAB3GAP2 0 0 244 323 1 1
TECPR2 LITAF 0 0 108 171 1 1
Ontologies
ID Category Term Effect Evidence PubMed
GO:0005515 Molecular Function protein binding enables IPI
GO:0006914 Biological Process autophagy involved_in IEA
GO:0032527 Biological Process protein exit from endoplasmic reticulum involved_in IBA
GO:0032527 Biological Process protein exit from endoplasmic reticulum involved_in IMP
GO:0005737 Cellular Component cytoplasm located_in IEA
Pathways
Name DB ID
Transcripts
Accession Version MolecularType Name NCBI Comments
NM_014844 5 mRNA transcript variant 1 NC_000014 Reference
NM_001172631 3 mRNA transcript variant 2 NC_000014 Reference